ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count GO:0050852 T cell receptor signaling pathway 37/1036 202/18670 1.14e-10 6.094e-07 5.382e-07 CD247/HLA-DRB4/NFKB1/TRAT1/SKP1/MALT1/BTN3A3/NCK1/PSMA2/PRKCQ/HLA-DQB1/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PDE4B/PTPN22/TRAC/PSME4/WAS/TXK/ITK/PSMD12/LCK/PIK3CA/RFTN1/PSMB1/STK11/PSMD10/CUL1/CD3E/LILRB4/PIK3R1/PSMC5/TRBC1/PSMA3 37 GO:1903311 regulation of mRNA metabolic process 48/1036 324/18670 4.676e-10 1.249e-06 1.103e-06 TRA2B/SRSF8/CTR9/C1QBP/SRSF10/PSMA2/TNFSF13/HNRNPA0/DCP1A/PSMA5/PSMD14/FASTKD3/BTG2/PSMA1/ZFP36/PSMC2/SART3/TIA1/PSME4/PAIP1/EXOSC8/PSMD12/HNRNPR/NUDT21/NPM1/ELAVL1/PUM1/UBA52/PABPC1/RBM15/HNRNPA2B1/PSMB1/SERBP1/RBM15B/PSMD10/PRDX6/DYRK1A/KHDRBS2/UBB/RBM25/RBM7/KHSRP/PSMC5/NUP214/RBM8A/FXR1/PSMA3/ZBTB7A 48 GO:0006402 mRNA catabolic process 51/1036 364/18670 9.918e-10 1.767e-06 1.56e-06 GSPT2/PSMA2/TNFSF13/HNRNPA0/DCP1A/EIF4A3/PSMA5/PSMD14/FASTKD3/BTG2/PSMA1/ZFP36/PSMC2/RPL6/RPS7/PSME4/RPS5/PAIP1/EXOSC8/RPL35/PSMD12/RPS4Y1/HNRNPR/NPM1/UPF3A/ELAVL1/PUM1/TTC37/RPL35A/UBA52/PABPC1/PSMB1/RPL19/SERBP1/PSMD10/RPL29/RPL15/UBB/RPS21/RPL11/GSPT1/RPL22/LSM2/RPL36/KHSRP/PSMC5/NUP214/RBM8A/UPF3B/FXR1/PSMA3 51 GO:0006401 RNA catabolic process 53/1036 397/18670 2.658e-09 3.551e-06 3.136e-06 DROSHA/GSPT2/PSMA2/TNFSF13/HNRNPA0/DCP1A/EIF4A3/PSMA5/PSMD14/PPP1R8/FASTKD3/BTG2/PSMA1/ZFP36/PSMC2/RPL6/RPS7/PSME4/RPS5/PAIP1/EXOSC8/RPL35/PSMD12/RPS4Y1/HNRNPR/NPM1/UPF3A/ELAVL1/PUM1/TTC37/RPL35A/UBA52/PABPC1/PSMB1/RPL19/SERBP1/PSMD10/RPL29/RPL15/UBB/RPS21/RPL11/GSPT1/RPL22/LSM2/RPL36/KHSRP/PSMC5/NUP214/RBM8A/UPF3B/FXR1/PSMA3 53 GO:0070498 interleukin-1-mediated signaling pathway 22/1036 100/18670 2.194e-08 2.345e-05 2.07e-05 IL1A/NFKB1/IL6/IL1B/SKP1/PSMA2/TOLLIP/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/MAPK3/UBA52/PSMB1/PSMD10/CUL1/UBB/PSMC5/PSMA3 22 GO:0000375 RNA splicing, via transesterification reactions 49/1036 382/18670 3.867e-08 3.135e-05 2.769e-05 DHX15/TRA2B/SRSF8/SFPQ/C1QBP/DDX46/SRSF10/HNRNPF/SNIP1/HNRNPA0/EIF4A3/WBP11/SNRPD1/SART3/TIA1/PCF11/DDX1/CLNS1A/HNRNPR/NUDT21/COIL/PCBP1/ELAVL1/U2SURP/CSTF2T/PABPC1/LSM8/RBM15/PRPF8/HNRNPA2B1/RBM15B/SNRPF/PRDX6/CDC40/SNRPD2/DYRK1A/KHDRBS2/SETX/BCAS2/PQBP1/MPHOSPH10/RBM25/LSM2/RBM7/PRPF4B/KHSRP/RBM8A/UPF3B/ZBTB7A 49 GO:0070555 response to interleukin-1 33/1036 207/18670 4.107e-08 3.135e-05 2.769e-05 CD38/IL1A/NFKB1/CCL5/IL6/IL1B/SKP1/RORA/PSMA2/KMO/TOLLIP/PSMA5/PSMD14/PSMA1/PSMC2/GCLC/RBX1/PSME4/ANXA1/PSMD12/MAPK3/UBA52/HDAC4/PSMB1/CCL11/IGBP1/PSMD10/CUL1/UBB/CCL25/CCL23/PSMC5/PSMA3 33 GO:0030098 lymphocyte differentiation 46/1036 353/18670 6.269e-08 4.188e-05 3.698e-05 DROSHA/RHOH/ITM2A/SOS1/IL6/IFNG/TGFBR2/CD2/POU2F2/GPR18/MALT1/ITGA4/RORA/IL12B/CD8A/PTPN22/ANXA1/ITK/MSH2/RASGRP1/TBX21/BCL11B/LCK/XBP1/IL23A/RARA/RSAD2/CD83/HDAC4/LYL1/STK11/PTGER4/GPR183/ZBTB16/SPI1/IL15/SOD1/RPL22/CD3E/LILRB4/SLAMF8/PIK3R1/PGLYRP4/SATB1/ATG5/ZBTB7A 46 GO:0045333 cellular respiration 31/1036 193/18670 8.82e-08 5.237e-05 4.624e-05 MDH1/IFNG/SUCLA2/FLCN/DLD/CAT/CS/UQCRB/FASTKD3/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/NNT/SDHA/NDUFA4/NDUFA6/NDUFB4/ADSL/CYC1/OXA1L/ETFA/SUCLG2/PIK3CA/SUCLG1/FH/PDHB/NDUFS1/NDUFS4/COQ9 31 GO:0043488 regulation of mRNA stability 29/1036 177/18670 1.475e-07 6.778e-05 5.986e-05 PSMA2/TNFSF13/HNRNPA0/DCP1A/PSMA5/PSMD14/FASTKD3/PSMA1/ZFP36/PSMC2/PSME4/PAIP1/EXOSC8/PSMD12/HNRNPR/NPM1/ELAVL1/PUM1/UBA52/PABPC1/PSMB1/SERBP1/PSMD10/UBB/KHSRP/PSMC5/NUP214/FXR1/PSMA3 29 GO:0030217 T cell differentiation 35/1036 240/18670 1.568e-07 6.778e-05 5.986e-05 DROSHA/RHOH/SOS1/IL6/IFNG/TGFBR2/CD2/GPR18/MALT1/RORA/IL12B/CD8A/PTPN22/ANXA1/ITK/RASGRP1/TBX21/BCL11B/LCK/XBP1/IL23A/RARA/RSAD2/CD83/STK11/PTGER4/GPR183/ZBTB16/IL15/SOD1/RPL22/CD3E/LILRB4/SATB1/ATG5 35 GO:0015980 energy derivation by oxidation of organic compounds 39/1036 285/18670 1.746e-07 6.778e-05 5.986e-05 DYRK2/MDH1/MYC/IFNG/SUCLA2/FLCN/PASK/DLD/CAT/GNAS/CS/UQCRB/FASTKD3/NDUFV1/CYCS/UGP2/NDUFV2/PPP1CC/COX6C/NDUFA10/NNT/SDHA/NDUFA4/NDUFA6/PHKG1/NDUFB4/ADSL/CYC1/OXA1L/ETFA/SUCLG2/PIK3CA/SUCLG1/FH/PDHB/NDUFS1/NDUFS4/COQ9/GFPT1 39 GO:0042254 ribosome biogenesis 40/1036 297/18670 1.874e-07 6.778e-05 5.986e-05 DROSHA/ZNHIT3/NSA2/ZNHIT6/UTP3/C1QBP/TFB2M/FBL/EIF4A3/WBP11/NOL11/RPL6/RPF1/EMG1/RPS7/TRMT61B/RPS5/MDN1/EXOSC8/RPL35/DDX21/DDX51/THUMPD1/NPM1/RPL35A/TRMT112/RIOK2/RSL24D1/MRPL22/RRS1/KRR1/WDR55/DIMT1/RPS21/RPL11/WDR12/MPHOSPH10/PWP2/GTF3A/SHQ1 40 GO:0016072 rRNA metabolic process 36/1036 253/18670 1.953e-07 6.778e-05 5.986e-05 DROSHA/ZNHIT3/NSA2/ZNHIT6/UTP3/GTF3C3/TFB2M/FBL/EIF4A3/WBP11/NOL11/POLR1B/RPF1/EMG1/RPS7/TRMT61B/MDN1/EXOSC8/RPL35/DDX21/DDX51/THUMPD1/RPL35A/TRMT112/RIOK2/RRS1/KRR1/WDR55/DIMT1/RPS21/RPL11/WDR12/MPHOSPH10/PWP2/GTF3A/SHQ1 36 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 47/1036 379/18670 2.029e-07 6.778e-05 5.986e-05 DHX15/TRA2B/SRSF8/SFPQ/C1QBP/DDX46/SRSF10/HNRNPF/SNIP1/HNRNPA0/EIF4A3/WBP11/SNRPD1/SART3/TIA1/PCF11/DDX1/CLNS1A/HNRNPR/NUDT21/COIL/PCBP1/ELAVL1/U2SURP/CSTF2T/PABPC1/LSM8/RBM15/PRPF8/HNRNPA2B1/RBM15B/SNRPF/PRDX6/CDC40/SNRPD2/DYRK1A/KHDRBS2/SETX/BCAS2/PQBP1/RBM25/LSM2/RBM7/PRPF4B/RBM8A/UPF3B/ZBTB7A 47 GO:0000398 mRNA splicing, via spliceosome 47/1036 379/18670 2.029e-07 6.778e-05 5.986e-05 DHX15/TRA2B/SRSF8/SFPQ/C1QBP/DDX46/SRSF10/HNRNPF/SNIP1/HNRNPA0/EIF4A3/WBP11/SNRPD1/SART3/TIA1/PCF11/DDX1/CLNS1A/HNRNPR/NUDT21/COIL/PCBP1/ELAVL1/U2SURP/CSTF2T/PABPC1/LSM8/RBM15/PRPF8/HNRNPA2B1/RBM15B/SNRPF/PRDX6/CDC40/SNRPD2/DYRK1A/KHDRBS2/SETX/BCAS2/PQBP1/RBM25/LSM2/RBM7/PRPF4B/RBM8A/UPF3B/ZBTB7A 47 GO:0008380 RNA splicing 54/1036 469/18670 2.957e-07 8.613e-05 7.606e-05 DHX15/TRA2B/SRSF8/SFPQ/C1QBP/DDX46/SRSF10/HNRNPF/SNIP1/HNRNPA0/EIF4A3/WBP11/SNRPD1/PPP1R8/SART3/TIA1/PCF11/DDX1/CLNS1A/CLK2/HNRNPR/NUDT21/COIL/PCBP1/ELAVL1/U2SURP/CSTF2T/PABPC1/LSM8/RBM15/PRPF8/HNRNPA2B1/RBM15B/SNRPF/PRDX6/PRPF38B/CDC40/SNRPD2/DYRK1A/KHDRBS2/SETX/BCAS2/PQBP1/AKAP17A/MPHOSPH10/RBM25/LSM2/RBM7/PIK3R1/PRPF4B/KHSRP/RBM8A/UPF3B/ZBTB7A 54 GO:0006364 rRNA processing 32/1036 214/18670 2.974e-07 8.613e-05 7.606e-05 ZNHIT3/NSA2/ZNHIT6/UTP3/TFB2M/FBL/EIF4A3/WBP11/NOL11/RPF1/EMG1/RPS7/TRMT61B/MDN1/EXOSC8/RPL35/DDX21/DDX51/THUMPD1/RPL35A/TRMT112/RIOK2/RRS1/KRR1/WDR55/DIMT1/RPS21/RPL11/WDR12/MPHOSPH10/PWP2/SHQ1 32 GO:0043487 regulation of RNA stability 29/1036 183/18670 3.062e-07 8.613e-05 7.606e-05 PSMA2/TNFSF13/HNRNPA0/DCP1A/PSMA5/PSMD14/FASTKD3/PSMA1/ZFP36/PSMC2/PSME4/PAIP1/EXOSC8/PSMD12/HNRNPR/NPM1/ELAVL1/PUM1/UBA52/PABPC1/PSMB1/SERBP1/PSMD10/UBB/KHSRP/PSMC5/NUP214/FXR1/PSMA3 29 GO:0006403 RNA localization 33/1036 230/18670 5.156e-07 0.0001378 0.0001217 ZNHIT3/ZNHIT6/NUP107/TGFBR2/CCT7/SFPQ/FBL/NUP37/EIF4A3/ZFP36/CCT2/NUP205/ATR/NPM1/UPF3A/PARP11/NUP85/RFTN1/TNKS/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/TOMM20/LUZP4/NUP160/TERF1/KHSRP/NUP214/RBM8A/UPF3B/SHQ1 33 GO:0061013 regulation of mRNA catabolic process 30/1036 199/18670 5.804e-07 0.0001419 0.0001253 PSMA2/TNFSF13/HNRNPA0/DCP1A/PSMA5/PSMD14/FASTKD3/BTG2/PSMA1/ZFP36/PSMC2/PSME4/PAIP1/EXOSC8/PSMD12/HNRNPR/NPM1/ELAVL1/PUM1/UBA52/PABPC1/PSMB1/SERBP1/PSMD10/UBB/KHSRP/PSMC5/NUP214/FXR1/PSMA3 30 GO:0046632 alpha-beta T cell differentiation 20/1036 101/18670 5.84e-07 0.0001419 0.0001253 IL6/IFNG/TGFBR2/GPR18/MALT1/RORA/IL12B/ANXA1/ITK/TBX21/BCL11B/IL23A/RARA/RSAD2/CD83/PTGER4/GPR183/ZBTB16/RPL22/SATB1 20 GO:0071347 cellular response to interleukin-1 28/1036 179/18670 6.398e-07 0.0001456 0.0001286 IL1A/NFKB1/CCL5/IL6/IL1B/SKP1/RORA/PSMA2/KMO/TOLLIP/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/MAPK3/UBA52/PSMB1/CCL11/PSMD10/CUL1/UBB/CCL25/CCL23/PSMC5/PSMA3 28 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 22/1036 120/18670 6.538e-07 0.0001456 0.0001286 GSPT2/DCP1A/EIF4A3/RPL6/RPS7/RPS5/RPL35/RPS4Y1/UPF3A/RPL35A/UBA52/PABPC1/RPL19/RPL29/RPL15/RPS21/RPL11/GSPT1/RPL22/RPL36/RBM8A/UPF3B 22 GO:0045089 positive regulation of innate immune response 45/1036 381/18670 1.437e-06 0.0003071 0.0002712 NFKB1/CCL5/SH2D1A/SFPQ/C1QBP/SKP1/MALT1/PSMA2/PRKACB/PSPC1/IL12B/PSMA5/PSMD14/PSMA1/PSMC2/FYN/BIRC3/PTPN22/DDX60/ANKRD17/PSME4/MUC2/TXK/PSMD12/RASGRP1/TLR3/PUM1/RSAD2/UBA52/RFTN1/POLR3C/PSMB1/ALPK1/TLR6/PSMD10/CUL1/FCN1/UBB/PQBP1/RPS6KA3/PGLYRP4/PSMC5/GPATCH3/LBP/PSMA3 45 GO:0034470 ncRNA processing 45/1036 384/18670 1.78e-06 0.0003658 0.000323 DROSHA/ZNHIT3/NSA2/ZNHIT6/UTP3/TFB2M/FBL/SEPHS1/INTS12/EIF4A3/WBP11/NOL11/RPF1/INTS8/EMG1/TARBP1/RPS7/TRMT61B/MDN1/EXOSC8/POLR3K/DDX1/RPL35/DDX21/PRKRA/DDX51/CDK5RAP1/THUMPD1/MTO1/RPL35A/TRMT5/HNRNPA2B1/TRMT112/TPRKB/RIOK2/RRS1/KRR1/WDR55/DIMT1/RPS21/RPL11/WDR12/MPHOSPH10/PWP2/SHQ1 45 GO:0046631 alpha-beta T cell activation 23/1036 138/18670 2.074e-06 0.0004105 0.0003625 IL6/IFNG/TGFBR2/GPR18/MALT1/RORA/PRKCQ/IL12B/ANXA1/ITK/TBX21/BCL11B/IL23A/RARA/RSAD2/CD83/PTGER4/GPR183/ZBTB16/IL15/RPL22/CD3E/SATB1 23 GO:0050851 antigen receptor-mediated signaling pathway 39/1036 316/18670 2.46e-06 0.0004466 0.0003943 CD247/CD38/HLA-DRB4/NFKB1/TRAT1/SKP1/PRKCH/MALT1/BTN3A3/NCK1/PSMA2/PRKCQ/HLA-DQB1/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PDE4B/PTPN22/TRAC/PSME4/WAS/TXK/ITK/PSMD12/LCK/PIK3CA/RFTN1/PSMB1/STK11/PSMD10/CUL1/CD3E/LILRB4/PIK3R1/PSMC5/TRBC1/PSMA3 39 GO:1902749 regulation of cell cycle G2/M phase transition 30/1036 213/18670 2.479e-06 0.0004466 0.0003943 NAE1/CEP57/SKP1/TOPBP1/CDC25B/PSMA2/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/RBX1/PSME4/PSMD12/SMARCD3/NPM1/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/DYRK3/CLASP1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/CDC7/PSMA3 30 GO:0001819 positive regulation of cytokine production 51/1036 464/18670 2.507e-06 0.0004466 0.0003943 IL1A/NFKB1/IL6/IFNG/CD2/IL1B/C1QBP/MALT1/RORA/PRKCQ/IL12B/CD244/PDE4B/BIRC3/TNF/PTPN22/DDX60/ANKRD17/TXK/IL36A/POLR3K/ANXA1/DDX1/LRP1/DDX21/RASGRP1/TLR3/XBP1/SULF1/IL23A/PUM1/RARA/MBP/RSAD2/MAPK3/CD83/POLR3C/ELANE/AGPAT2/PTGER4/TLR6/HEG1/IL15/FCN1/SOD1/PQBP1/CD3E/PIK3R1/GPATCH3/IL17B/LBP 51 GO:0002218 activation of innate immune response 39/1036 319/18670 3.102e-06 0.0005347 0.0004722 NFKB1/SFPQ/C1QBP/SKP1/MALT1/PSMA2/PRKACB/PSPC1/PSMA5/PSMD14/PSMA1/PSMC2/FYN/BIRC3/PTPN22/DDX60/ANKRD17/PSME4/MUC2/PSMD12/TLR3/PUM1/RSAD2/UBA52/RFTN1/PSMB1/ALPK1/TLR6/PSMD10/CUL1/FCN1/UBB/PQBP1/RPS6KA3/PGLYRP4/PSMC5/GPATCH3/LBP/PSMA3 39 GO:0140053 mitochondrial gene expression 25/1036 162/18670 3.231e-06 0.0005396 0.0004765 IARS2/C1QBP/TFB2M/PTCD3/MRPL42/MRPS30/FASTKD3/NGRN/TRMT61B/MTIF2/MRPL9/CDK5RAP1/OXA1L/MRPS17/MRPS28/MTO1/TRMT5/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/MRPS14/MRPL28/MRPL16 25 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 16/1036 77/18670 4.006e-06 0.000632 0.0005581 PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/UBA52/PSMB1/CITED2/PSMD10/UBB/CA9/PSMC5/PSMA3 16 GO:0010389 regulation of G2/M transition of mitotic cell cycle 28/1036 196/18670 4.021e-06 0.000632 0.0005581 NAE1/CEP57/SKP1/TOPBP1/CDC25B/PSMA2/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/RBX1/PSME4/PSMD12/SMARCD3/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/CLASP1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/CDC7/PSMA3 28 GO:0071824 protein-DNA complex subunit organization 36/1036 288/18670 4.437e-06 0.0006775 0.0005983 PARP1/MYC/ITGB3BP/HAT1/ACTR6/GTF3C3/RBBP4/GTF2A2/ORC3/PSMC2/SART3/RBX1/HIRA/PSME4/GTF2H3/NAP1L1/SMARCD3/NPM1/GMNN/TSPY1/UBA52/TBP/RBBP7/DAXX/UBB/ZNHIT1/ATRX/RNF4/TAF1C/RPA1/GTF2E1/TAF12/TERF1/PSMC5/MCM6/SMARCA5 36 GO:0009060 aerobic respiration 17/1036 87/18670 4.892e-06 0.0007253 0.0006405 MDH1/SUCLA2/DLD/CAT/CS/UQCRB/CYCS/COX6C/NNT/SDHA/NDUFA4/ADSL/OXA1L/SUCLG2/SUCLG1/FH/PDHB 17 GO:0043484 regulation of RNA splicing 22/1036 135/18670 5.022e-06 0.0007253 0.0006405 TRA2B/SRSF8/C1QBP/SRSF10/HNRNPF/SART3/TIA1/CLK2/RBM15/HNRNPA2B1/RBM15B/PRDX6/DYRK1A/KHDRBS2/SETX/PQBP1/AKAP17A/RBM25/RBM7/PIK3R1/RBM8A/ZBTB7A 22 GO:0009123 nucleoside monophosphate metabolic process 43/1036 375/18670 5.265e-06 0.0007404 0.0006538 PARP1/PGK1/NUP107/IFNG/PRPS2/DCK/AK6/FLCN/CMPK1/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/PRPS1/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MSH2/NDUFA6/NDUFB4/DNM1L/UCKL1/ADSL/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NUDT9/APRT/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 43 GO:0045088 regulation of innate immune response 49/1036 452/18670 5.77e-06 0.0007907 0.0006982 CD96/NFKB1/CCL5/SH2D1A/IFNG/SFPQ/C1QBP/SKP1/MALT1/PSMA2/PRKACB/PSPC1/IL12B/PSMA5/PSMD14/PSMA1/PSMC2/FYN/BIRC3/PTPN22/DDX60/ANKRD17/PSME4/MUC2/TXK/PSMD12/RASGRP1/TLR3/PUM1/RSAD2/UBA52/RFTN1/POLR3C/PSMB1/ALPK1/USP18/TLR6/PSMD10/CUL1/FCN1/UBB/PQBP1/RPS6KA3/SLAMF8/PGLYRP4/PSMC5/GPATCH3/LBP/PSMA3 49 GO:0043620 regulation of DNA-templated transcription in response to stress 21/1036 127/18670 6.474e-06 0.0008649 0.0007638 NCK1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/BCLAF1/RBX1/ATF3/PSME4/PSMD12/DNAJB1/UBA52/PSMB1/CITED2/PSMD10/UBB/RPS6KA3/CA9/PSMC5/PSMA3 21 GO:0009161 ribonucleoside monophosphate metabolic process 41/1036 354/18670 6.788e-06 0.0008847 0.0007812 PARP1/PGK1/NUP107/IFNG/PRPS2/FLCN/CMPK1/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/PRPS1/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MSH2/NDUFA6/NDUFB4/DNM1L/UCKL1/ADSL/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NUDT9/APRT/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 41 GO:0031145 anaphase-promoting complex-dependent catabolic process 16/1036 81/18670 7.988e-06 0.001016 0.0008975 CDC23/PSMA2/ANAPC5/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/UBA52/PSMB1/FBXO5/PSMD10/UBB/PSMC5/PSMA3 16 GO:0002758 innate immune response-activating signal transduction 36/1036 298/18670 9.622e-06 0.001196 0.001056 NFKB1/C1QBP/SKP1/MALT1/PSMA2/PRKACB/PSMA5/PSMD14/PSMA1/PSMC2/FYN/BIRC3/PTPN22/DDX60/ANKRD17/PSME4/MUC2/PSMD12/TLR3/PUM1/RSAD2/UBA52/RFTN1/PSMB1/ALPK1/TLR6/PSMD10/CUL1/FCN1/UBB/RPS6KA3/PGLYRP4/PSMC5/GPATCH3/LBP/PSMA3 36 GO:0006099 tricarboxylic acid cycle 10/1036 34/18670 1.024e-05 0.001243 0.001098 MDH1/SUCLA2/DLD/CS/NNT/SDHA/SUCLG2/SUCLG1/FH/PDHB 10 GO:0051236 establishment of RNA localization 27/1036 196/18670 1.177e-05 0.001398 0.001234 NUP107/TGFBR2/SFPQ/NUP37/EIF4A3/ZFP36/NUP205/ATR/NPM1/UPF3A/PARP11/NUP85/RFTN1/TNKS/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/TOMM20/LUZP4/NUP160/TERF1/KHSRP/NUP214/RBM8A/UPF3B 27 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 17/1036 93/18670 1.246e-05 0.001432 0.001264 NAE1/SKP1/TOPBP1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PSMB1/PSMD10/CUL1/DONSON/PSMC5/PSMA3 17 GO:0009615 response to virus 38/1036 326/18670 1.26e-05 0.001432 0.001264 CCL5/IL6/IFNG/IL1B/LGALS8/C1QBP/PSMA2/IFI44L/ODC1/IL12B/PRF1/IFIT2/HTRA1/BIRC3/TNF/DDX60/ANKRD17/TRIM44/CXCR4/POLR3K/DDX1/DDX21/PRKRA/TBX21/TLR3/IL23A/PUM1/RSAD2/POLR3C/AIMP1/CHRM2/CCL11/APOBEC3G/IL15/PMAIP1/PQBP1/ZMYND11/GPATCH3 38 GO:0044839 cell cycle G2/M phase transition 33/1036 266/18670 1.286e-05 0.001432 0.001264 OPTN/NAE1/ABCB1/CEP57/SKP1/TOPBP1/CDC25B/PSMA2/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/RBX1/PSME4/PSMD12/SMARCD3/NPM1/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/DYRK3/CLASP1/FBXO5/PSMD10/PKMYT1/CUL1/DONSON/PSMC5/CDC7/PSMA3 33 GO:0006101 citrate metabolic process 10/1036 35/18670 1.362e-05 0.001486 0.001312 MDH1/SUCLA2/DLD/CS/NNT/SDHA/SUCLG2/SUCLG1/FH/PDHB 10 GO:0006415 translational termination 18/1036 104/18670 1.531e-05 0.001637 0.001445 GSPT2/PTCD3/MRPL42/MRPS30/MRPL9/OXA1L/MRPS17/MRPS28/TRMT112/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/GSPT1/MRPS14/MRPL28/MRPL16 18 GO:0032543 mitochondrial translation 21/1036 135/18670 1.708e-05 0.00179 0.001581 IARS2/C1QBP/PTCD3/MRPL42/MRPS30/FASTKD3/NGRN/MTIF2/MRPL9/CDK5RAP1/OXA1L/MRPS17/MRPS28/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/MRPS14/MRPL28/MRPL16 21 GO:0000086 G2/M transition of mitotic cell cycle 31/1036 247/18670 1.852e-05 0.001878 0.001658 OPTN/NAE1/ABCB1/CEP57/SKP1/TOPBP1/CDC25B/PSMA2/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/RBX1/PSME4/PSMD12/SMARCD3/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/CLASP1/FBXO5/PSMD10/PKMYT1/CUL1/DONSON/PSMC5/CDC7/PSMA3 31 GO:0062012 regulation of small molecule metabolic process 48/1036 459/18670 1.862e-05 0.001878 0.001658 PARP1/DYRK2/NFKB1/PGK1/NUP107/IFNG/IL1B/DUSP12/FLCN/IDI1/PASK/RORA/NUP37/PSMA2/INSIG1/ODC1/LDLRAP1/PSMA5/PSMD14/PSMA1/PSMC2/CD244/NTSR1/CRY1/COX11/TNF/PSME4/NUP205/ANXA1/PSMD12/CLK2/DNM1L/NFYB/NUP85/SPHK2/HDAC4/PSMB1/AKR1C3/PSMD10/SC5D/PMAIP1/SOD1/NCOR1/NUP160/PSMC5/NUP214/PSMA3/ZBTB7A 48 GO:0002220 innate immune response activating cell surface receptor signaling pathway 19/1036 116/18670 2.022e-05 0.002001 0.001767 NFKB1/SKP1/MALT1/PSMA2/PRKACB/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PSME4/MUC2/PSMD12/PSMB1/PSMD10/CUL1/FCN1/PSMC5/PSMA3 19 GO:1903706 regulation of hemopoiesis 49/1036 475/18670 2.19e-05 0.002128 0.001879 DROSHA/MYC/SOS1/IFNG/TGFBR2/GPR171/CD2/CTR9/FLCN/MALT1/PSMA2/PRKCQ/GNAS/HSPA9/IL12B/PSMA5/PSMD14/PSMA1/ZFP36/PSMC2/TNF/PSME4/ANXA1/PSMD12/RASGRP1/TBX21/NUDT21/TLR3/XBP1/IL23A/RARA/LILRB3/LIF/CD83/RBM15/PSMB1/ZBTB16/SPI1/PSMD10/IL15/HAX1/SOD1/LILRB4/SLAMF8/PIK3R1/PGLYRP4/PSMC5/NCAPG2/PSMA3 49 GO:0045727 positive regulation of translation 20/1036 127/18670 2.24e-05 0.002137 0.001887 CCL5/IL6/C1QBP/NCK1/PASK/EIF4A3/FASTKD3/USP16/TNF/NGRN/PAIP1/CDK5RAP1/NPM1/UPF3A/ELAVL1/MAPK3/PABPC1/CNBP/UPF3B/FXR1 20 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 13/1036 61/18670 2.39e-05 0.002241 0.001979 SFPQ/FLCN/NCK1/BCLAF1/RPS7/PRKRA/DNM1L/LCK/PIAS4/UBB/PMAIP1/RPL11/SOD1 13 GO:0015931 nucleobase-containing compound transport 30/1036 241/18670 2.94e-05 0.002709 0.002392 NUP107/SLC35D1/TGFBR2/SFPQ/SLC25A32/NUP37/EIF4A3/SLC25A5/ZFP36/SLC35A5/NUP205/SLC35A1/NPM1/UPF3A/PARP11/NUP85/RFTN1/TNKS/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/TOMM20/LUZP4/NUP160/KHSRP/NUP214/RBM8A/UPF3B 30 GO:1903039 positive regulation of leukocyte cell-cell adhesion 28/1036 218/18670 3.038e-05 0.002752 0.00243 CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/ITGA4/PRKCQ/IL12B/ICOS/FYN/TNF/ANXA1/RASGRP1/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ELANE/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/EFNB3 28 GO:0000956 nuclear-transcribed mRNA catabolic process 27/1036 207/18670 3.182e-05 0.002834 0.002502 GSPT2/DCP1A/EIF4A3/BTG2/ZFP36/RPL6/RPS7/RPS5/EXOSC8/RPL35/RPS4Y1/UPF3A/TTC37/RPL35A/UBA52/PABPC1/RPL19/RPL29/RPL15/RPS21/RPL11/GSPT1/RPL22/LSM2/RPL36/RBM8A/UPF3B 27 GO:0002181 cytoplasmic translation 17/1036 100/18670 3.331e-05 0.002918 0.002577 EIF4B/NCK1/GSPT2/RPL6/RWDD1/RPL35A/HSPA14/RPL19/RPL29/RPL15/EIF5/RPS21/RPL11/GSPT1/ZC3H15/CNBP/RPL36 17 GO:0022409 positive regulation of cell-cell adhesion 31/1036 255/18670 3.465e-05 0.002987 0.002637 CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/ITGA4/PRKCQ/ITGA6/IL12B/ICOS/FYN/TNF/ANXA1/KIFAP3/RASGRP1/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ELANE/CITED2/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/EFNB3 31 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 19/1036 121/18670 3.712e-05 0.003149 0.002781 NCK1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/ATF3/PSME4/PSMD12/DNAJB1/UBA52/PSMB1/CITED2/PSMD10/UBB/CA9/PSMC5/PSMA3 19 GO:0034250 positive regulation of cellular amide metabolic process 22/1036 153/18670 3.811e-05 0.003167 0.002796 CCL5/IL6/IFNG/C1QBP/NCK1/PASK/EIF4A3/FASTKD3/USP16/TNF/NGRN/PAIP1/CDK5RAP1/NPM1/UPF3A/ELAVL1/MAPK3/PABPC1/SPHK2/CNBP/UPF3B/FXR1 22 GO:0072350 tricarboxylic acid metabolic process 10/1036 39/18670 3.852e-05 0.003167 0.002796 MDH1/SUCLA2/DLD/CS/NNT/SDHA/SUCLG2/SUCLG1/FH/PDHB 10 GO:0050688 regulation of defense response to virus 14/1036 73/18670 4.119e-05 0.003335 0.002945 IL1B/C1QBP/IL12B/HTRA1/BIRC3/DDX60/ANKRD17/TRIM44/IL23A/PUM1/APOBEC3G/IL15/PQBP1/GPATCH3 14 GO:0035710 CD4-positive, alpha-beta T cell activation 16/1036 92/18670 4.225e-05 0.00337 0.002975 IL6/IFNG/TGFBR2/MALT1/RORA/PRKCQ/IL12B/ANXA1/TBX21/IL23A/RARA/RSAD2/CD83/PTGER4/GPR183/SATB1 16 GO:0043367 CD4-positive, alpha-beta T cell differentiation 14/1036 74/18670 4.824e-05 0.003761 0.003321 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/RSAD2/CD83/PTGER4/GPR183/SATB1 14 GO:0002223 stimulatory C-type lectin receptor signaling pathway 18/1036 113/18670 4.856e-05 0.003761 0.003321 NFKB1/SKP1/MALT1/PSMA2/PRKACB/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PSME4/MUC2/PSMD12/PSMB1/PSMD10/CUL1/PSMC5/PSMA3 18 GO:0065004 protein-DNA complex assembly 30/1036 248/18670 5.055e-05 0.003859 0.003408 PARP1/ITGB3BP/HAT1/GTF3C3/RBBP4/GTF2A2/ORC3/PSMC2/SART3/RBX1/HIRA/GTF2H3/NAP1L1/NPM1/GMNN/TSPY1/UBA52/TBP/RBBP7/DAXX/UBB/ATRX/RNF4/TAF1C/RPA1/TAF12/TERF1/PSMC5/MCM6/SMARCA5 30 GO:1901532 regulation of hematopoietic progenitor cell differentiation 15/1036 85/18670 6.11e-05 0.004599 0.004061 SOS1/FLCN/PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/NUDT21/PSMB1/PSMD10/PSMC5/PSMA3 15 GO:1902750 negative regulation of cell cycle G2/M phase transition 17/1036 105/18670 6.324e-05 0.004694 0.004145 NAE1/SKP1/TOPBP1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PSMB1/PSMD10/CUL1/DONSON/PSMC5/PSMA3 17 GO:0006413 translational initiation 25/1036 193/18670 6.907e-05 0.004921 0.004346 CCL5/EIF4B/NCK1/EIF1AX/RPL6/TNF/RPS7/RPS5/MTIF2/PAIP1/DDX1/RPL35/RPS4Y1/NPM1/RPL35A/UBA52/PABPC1/RPL19/RPL29/RPL15/EIF5/RPS21/RPL11/RPL22/RPL36 25 GO:0050657 nucleic acid transport 25/1036 193/18670 6.907e-05 0.004921 0.004346 NUP107/TGFBR2/SFPQ/NUP37/EIF4A3/ZFP36/NUP205/NPM1/UPF3A/PARP11/NUP85/RFTN1/TNKS/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/TOMM20/LUZP4/NUP160/KHSRP/NUP214/RBM8A/UPF3B 25 GO:0050658 RNA transport 25/1036 193/18670 6.907e-05 0.004921 0.004346 NUP107/TGFBR2/SFPQ/NUP37/EIF4A3/ZFP36/NUP205/NPM1/UPF3A/PARP11/NUP85/RFTN1/TNKS/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/TOMM20/LUZP4/NUP160/KHSRP/NUP214/RBM8A/UPF3B 25 GO:0009167 purine ribonucleoside monophosphate metabolic process 37/1036 340/18670 7.22e-05 0.005077 0.004483 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MSH2/NDUFA6/NDUFB4/DNM1L/ADSL/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NUDT9/APRT/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 37 GO:0006520 cellular amino acid metabolic process 39/1036 366/18670 7.374e-05 0.005118 0.004519 ABAT/IARS2/SLC25A32/ADO/PSMA2/DLD/SEPHS1/ENOSF1/PPA1/PLOD1/ODC1/KMO/MTR/PSMA5/PSMD14/PSMA1/PSMC2/GCLC/PSME4/PSMD12/EEF1E1/QDPR/AHCY/BCKDHA/MCCC1/KYNU/AIMP1/OTC/PSMB1/CBS/PSMD10/ASNSD1/AASDHPPT/GAD2/PSMC5/ACAT1/SLC1A3/GFPT1/PSMA3 39 GO:0009126 purine nucleoside monophosphate metabolic process 37/1036 341/18670 7.678e-05 0.00526 0.004645 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MSH2/NDUFA6/NDUFB4/DNM1L/ADSL/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NUDT9/APRT/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 37 GO:0038061 NIK/NF-kappaB signaling 24/1036 183/18670 7.86e-05 0.005317 0.004695 IL1B/NR3C2/SKP1/MALT1/PSMA2/IL12B/PSMA5/PSMD14/PSMA1/PSMC2/BIRC3/TNF/PTPN22/TRIM44/PSME4/PSMD12/TLR3/IL23A/PSMB1/TLR6/PSMD10/CUL1/PSMC5/PSMA3 24 GO:0006733 oxidoreduction coenzyme metabolic process 26/1036 207/18670 8.402e-05 0.005613 0.004956 CD38/PDSS1/MDH1/PGK1/NUP107/IFNG/LDHB/DERA/NUP37/DLD/KMO/PDHX/NNT/NUP205/GPD1L/NUP85/SLC22A13/KYNU/HDAC4/PFKP/PDHB/NCOR1/NUP160/NUP214/COQ9/ZBTB7A 26 GO:0046034 ATP metabolic process 34/1036 305/18670 8.719e-05 0.005752 0.00508 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MSH2/NDUFA6/NDUFB4/DNM1L/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 34 GO:0070125 mitochondrial translational elongation 15/1036 88/18670 9.227e-05 0.005939 0.005244 PTCD3/MRPL42/MRPS30/MRPL9/OXA1L/MRPS17/MRPS28/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/MRPS14/MRPL28/MRPL16 15 GO:0048024 regulation of mRNA splicing, via spliceosome 16/1036 98/18670 9.294e-05 0.005939 0.005244 TRA2B/SRSF8/C1QBP/SRSF10/SART3/TIA1/RBM15/HNRNPA2B1/RBM15B/PRDX6/DYRK1A/KHDRBS2/RBM25/RBM7/RBM8A/ZBTB7A 16 GO:0045073 regulation of chemokine biosynthetic process 6/1036 15/18670 9.335e-05 0.005939 0.005244 IL6/IFNG/IL1B/TNF/TLR3/ELANE 6 GO:0042110 T cell activation 46/1036 464/18670 0.0001009 0.006346 0.005604 DROSHA/RHOH/SOS1/CCL5/IL6/IFNG/TGFBR2/CD2/IL1B/GPR18/MALT1/NCK1/RORA/PRKCQ/IL12B/ICOS/FYN/CD8A/PTPN22/WAS/ANXA1/ITK/RASGRP1/TBX21/BCL11B/LCK/XBP1/IL23A/RARA/PIK3CA/RSAD2/CD83/STK11/PTGER4/GPR183/ZBTB16/IL15/SOD1/RPL22/CD3E/LILRB4/PIK3R1/SATB1/EFNB3/CLC/ATG5 46 GO:0001666 response to hypoxia 38/1036 359/18670 0.0001044 0.006473 0.005716 CD38/MYC/ABAT/PGK1/TGFBR2/RORA/PSMA2/CAT/HSD11B2/PLOD1/SOD3/PSMA5/PSMD14/PSMA1/PSMC2/SCFD1/RBX1/TGFBR3/CXCR4/PSME4/PSMD12/PHB2/CHCHD2/DNM1L/ADSL/AHCY/TRH/ATP1B1/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/ADAM15/CA9/PSMC5/PSMA3 38 GO:0070126 mitochondrial translational termination 15/1036 89/18670 0.0001054 0.006473 0.005716 PTCD3/MRPL42/MRPS30/MRPL9/OXA1L/MRPS17/MRPS28/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/MRPS14/MRPL28/MRPL16 15 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 9/1036 36/18670 0.0001164 0.007067 0.00624 IFNG/TGFBR2/MALT1/PRKCQ/IL12B/ANXA1/IL23A/RARA/CD83 9 GO:0009141 nucleoside triphosphate metabolic process 38/1036 362/18670 0.0001242 0.007456 0.006584 PARP1/PGK1/NUP107/IFNG/FLCN/CMPK1/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MFN1/MSH2/NDUFA6/NDUFB4/DNM1L/UCKL1/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/SUCLG1/PFKP/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 38 GO:0019083 viral transcription 23/1036 177/18670 0.0001265 0.007509 0.006631 CCL5/NUP107/NUP37/ZFP36/RPL6/RPS7/RPS5/NUP205/RPL35/RPS4Y1/USF2/RPL35A/NUP85/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/NUP160/RPL36/NUP214 23 GO:0019362 pyridine nucleotide metabolic process 24/1036 189/18670 0.0001308 0.00755 0.006667 CD38/MDH1/PGK1/NUP107/IFNG/LDHB/DERA/NUP37/DLD/KMO/PDHX/NNT/NUP205/GPD1L/NUP85/SLC22A13/KYNU/HDAC4/PFKP/PDHB/NCOR1/NUP160/NUP214/ZBTB7A 24 GO:0046496 nicotinamide nucleotide metabolic process 24/1036 189/18670 0.0001308 0.00755 0.006667 CD38/MDH1/PGK1/NUP107/IFNG/LDHB/DERA/NUP37/DLD/KMO/PDHX/NNT/NUP205/GPD1L/NUP85/SLC22A13/KYNU/HDAC4/PFKP/PDHB/NCOR1/NUP160/NUP214/ZBTB7A 24 GO:0006521 regulation of cellular amino acid metabolic process 12/1036 62/18670 0.0001314 0.00755 0.006667 PSMA2/ODC1/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 12 GO:0032649 regulation of interferon-gamma production 16/1036 101/18670 0.0001342 0.007628 0.006735 CD96/CD2/IL1B/C1QBP/IL12B/CD244/PDE4B/TNF/PTPN22/TXK/RASGRP1/TLR3/IL23A/RARA/CD3E/PGLYRP4 16 GO:0042033 chemokine biosynthetic process 6/1036 16/18670 0.0001424 0.007886 0.006964 IL6/IFNG/IL1B/TNF/TLR3/ELANE 6 GO:0050755 chemokine metabolic process 6/1036 16/18670 0.0001424 0.007886 0.006964 IL6/IFNG/IL1B/TNF/TLR3/ELANE 6 GO:0051607 defense response to virus 28/1036 238/18670 0.0001438 0.007886 0.006964 IL6/IFNG/IL1B/C1QBP/IFI44L/IL12B/PRF1/IFIT2/HTRA1/BIRC3/DDX60/ANKRD17/TRIM44/POLR3K/DDX1/DDX21/TLR3/IL23A/PUM1/RSAD2/POLR3C/AIMP1/APOBEC3G/IL15/PMAIP1/PQBP1/ZMYND11/GPATCH3 28 GO:0050870 positive regulation of T cell activation 25/1036 202/18670 0.0001446 0.007886 0.006964 CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/PRKCQ/IL12B/ICOS/FYN/ANXA1/RASGRP1/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/EFNB3 25 GO:0002367 cytokine production involved in immune response 16/1036 102/18670 0.0001511 0.008155 0.007201 CD96/IL6/IL1B/MALT1/IL12B/CHGA/TNF/DDX1/DDX21/TBX21/TLR3/RSAD2/MAPK3/SPHK2/CLC/ATG5 16 GO:0032609 interferon-gamma production 17/1036 113/18670 0.0001608 0.008595 0.007589 CD96/CD2/IL1B/C1QBP/IL12B/CD244/PDE4B/TNF/PTPN22/TXK/ITK/RASGRP1/TLR3/IL23A/RARA/CD3E/PGLYRP4 17 GO:1905330 regulation of morphogenesis of an epithelium 23/1036 180/18670 0.0001631 0.00863 0.007621 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/MAGED1/TNF/PSME4/PSMD12/PHB2/MLLT3/SULF1/LIF/PSMB1/CLASP1/PSMD10/ROR1/AP2B1/PSMC5/SIX2/FZD2/PSMA3 23 GO:0009199 ribonucleoside triphosphate metabolic process 36/1036 341/18670 0.0001655 0.008669 0.007655 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MFN1/MSH2/NDUFA6/NDUFB4/DNM1L/UCKL1/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 36 GO:0002699 positive regulation of immune effector process 26/1036 216/18670 0.0001694 0.008791 0.007762 IL6/SH2D1A/IFNG/IL1B/MALT1/TNFSF13/IL12B/CD244/TNF/DDX60/ANKRD17/ANXA1/DDX1/MSH2/CD1A/DDX21/RASGRP1/TBX21/XBP1/IL23A/PUM1/RARA/RSAD2/MAPK3/SPHK2/LBP 26 GO:0032743 positive regulation of interleukin-2 production 8/1036 30/18670 0.0001712 0.008799 0.007769 IL1A/IL1B/MALT1/PRKCQ/PDE4B/ANXA1/CD83/CD3E 8 GO:0032984 protein-containing complex disassembly 35/1036 329/18670 0.0001748 0.008896 0.007855 MYC/KIF2A/ATG14/GSPT2/PTCD3/MRPL42/ADD3/MRPS30/MICAL1/TNF/ZFAND1/MTIF2/CKAP2/MRPL9/SMARCD3/OXA1L/MRPS17/MRPS28/FYCO1/TRMT112/MRPL52/DYRK3/MRPL39/CLASP1/MRPL22/SETX/MRPS33/MRPL19/GSPT1/MCOLN1/MRPS14/MRPL28/SH3BP1/FZD2/MRPL16 35 GO:0042035 regulation of cytokine biosynthetic process 17/1036 114/18670 0.0001794 0.009046 0.007988 IL1A/NFKB1/IL6/IFNG/IL1B/PRKCQ/IL12B/ZFP36/TNF/TIA1/TRIB2/TLR3/ELANE/TLR6/CD3E/UBE2J1/LBP 17 GO:0036293 response to decreased oxygen levels 38/1036 370/18670 0.0001945 0.009714 0.008578 CD38/MYC/ABAT/PGK1/TGFBR2/RORA/PSMA2/CAT/HSD11B2/PLOD1/SOD3/PSMA5/PSMD14/PSMA1/PSMC2/SCFD1/RBX1/TGFBR3/CXCR4/PSME4/PSMD12/PHB2/CHCHD2/DNM1L/ADSL/AHCY/TRH/ATP1B1/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/ADAM15/CA9/PSMC5/PSMA3 38 GO:0030522 intracellular receptor signaling pathway 31/1036 280/18670 0.0001985 0.009824 0.008675 LBH/PARP1/CREM/TRIM68/C1QBP/RORA/NR2C1/CRY1/BIRC3/PTPN22/DDX60/RWDD1/ANKRD17/PHB2/NCOA3/PUM1/RARA/ASXL2/UBA52/ALPK1/CITED2/AKR1C3/GHRHR/KDM5D/DAXX/UBB/RNF4/TRIM24/NCOR1/GPATCH3/ZBTB7A 31 GO:0032729 positive regulation of interferon-gamma production 12/1036 65/18670 0.0002102 0.01018 0.008992 CD2/IL1B/IL12B/CD244/PDE4B/TNF/PTPN22/TXK/RASGRP1/TLR3/IL23A/CD3E 12 GO:0007584 response to nutrient 26/1036 219/18670 0.0002116 0.01018 0.008992 PCNA/HAT1/TGFBR2/IL1B/P2RX5/OXCT1/CAT/P2RX1/GCLC/FYN/NNT/ADSL/XBP1/AHCY/USF2/RARA/TNKS/KYNU/OTC/AKR1C3/P2RX6/IL15/SOD1/ACSL3/TRIM24/CD3E 26 GO:0072524 pyridine-containing compound metabolic process 24/1036 195/18670 0.000212 0.01018 0.008992 CD38/MDH1/PGK1/NUP107/IFNG/LDHB/DERA/NUP37/DLD/KMO/PDHX/NNT/NUP205/GPD1L/NUP85/SLC22A13/KYNU/HDAC4/PFKP/PDHB/NCOR1/NUP160/NUP214/ZBTB7A 24 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 16/1036 105/18670 0.0002134 0.01018 0.008992 RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/RPL36 16 GO:0002456 T cell mediated immunity 16/1036 106/18670 0.0002386 0.01129 0.009966 IL6/IL1B/MALT1/BTN3A3/CTSC/IL12B/PRF1/CD8A/WAS/CD1A/TBX21/EMP2/IL23A/RSAD2/RFTN1/CLC 16 GO:0009205 purine ribonucleoside triphosphate metabolic process 35/1036 335/18670 0.0002475 0.0116 0.01024 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MFN1/MSH2/NDUFA6/NDUFB4/DNM1L/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 35 GO:0000380 alternative mRNA splicing, via spliceosome 13/1036 76/18670 0.000257 0.01194 0.01055 TRA2B/SRSF8/SFPQ/SRSF10/SART3/RBM15/RBM15B/DYRK1A/PQBP1/RBM25/RBM7/RBM8A/ZBTB7A 13 GO:0016999 antibiotic metabolic process 20/1036 151/18670 0.0002634 0.01213 0.01071 MDH1/SUCLA2/DLD/CAT/CS/HP/FYN/NNT/SDHA/GNE/SUCLG2/AKR7A2/AKR1B1/SUCLG1/FH/AKR1C3/ALDH3B1/PRDX6/SOD1/PDHB 20 GO:0022900 electron transport chain 23/1036 186/18670 0.0002656 0.01213 0.01071 DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX11/COX6C/NDUFA10/SDHA/NDUFA4/NDUFA6/NDUFB4/CYC1/FDX1/QDPR/ETFA/AKR7A2/AKR1B1/RDH16/CYB5A/NDUFS1/NDUFS4/COQ9 23 GO:0045047 protein targeting to ER 17/1036 118/18670 0.0002739 0.0124 0.01095 RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/RPL36/SPCS1 17 GO:0042775 mitochondrial ATP synthesis coupled electron transport 15/1036 97/18670 0.0002824 0.01255 0.01108 DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NDUFA4/NDUFA6/NDUFB4/CYC1/NDUFS1/NDUFS4/COQ9 15 GO:0042108 positive regulation of cytokine biosynthetic process 12/1036 67/18670 0.0002826 0.01255 0.01108 IL1A/IL6/IFNG/IL1B/PRKCQ/IL12B/TNF/TLR3/ELANE/TLR6/CD3E/LBP 12 GO:0002697 regulation of immune effector process 44/1036 458/18670 0.0002842 0.01255 0.01108 CD96/IL6/SH2D1A/IFNG/IL1B/C1QBP/MALT1/TNFSF13/IL12B/HTRA1/CD244/BIRC3/TNF/DDX60/ANKRD17/TRIM44/C8B/WAS/ANXA1/DDX1/MSH2/CD1A/DDX21/RASGRP1/TBX21/TLR3/XBP1/IL23A/PUM1/RARA/RSAD2/MAPK3/SPHK2/APOBEC3G/IL15/PQBP1/CD5L/SLAMF8/PGLYRP4/GPATCH3/CLC/BCR/LBP/ATG5 44 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 16/1036 108/18670 0.0002969 0.01301 0.01149 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PSMB1/PSMD10/ROR1/AP2B1/PSMC5/FZD2/PSMA3 16 GO:0039535 regulation of RIG-I signaling pathway 6/1036 18/18670 0.0002999 0.01302 0.0115 C1QBP/BIRC3/DDX60/ANKRD17/PUM1/GPATCH3 6 GO:0002429 immune response-activating cell surface receptor signaling pathway 45/1036 473/18670 0.0003021 0.01302 0.0115 CD247/CD38/HLA-DRB4/NFKB1/TRAT1/SKP1/PRKCH/MALT1/BTN3A3/NCK1/PSMA2/PRKCQ/PRKACB/HLA-DQB1/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PDE4B/PTPN22/TRAC/PSME4/MUC2/WAS/TXK/ITK/PSMD12/CYFIP2/LCK/PIK3CA/MAPK3/RFTN1/ELMO2/PSMB1/STK11/PSMD10/CUL1/FCN1/CD3E/LILRB4/PIK3R1/PSMC5/TRBC1/PSMA3 45 GO:0042773 ATP synthesis coupled electron transport 15/1036 98/18670 0.0003167 0.01354 0.01195 DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NDUFA4/NDUFA6/NDUFB4/CYC1/NDUFS1/NDUFS4/COQ9 15 GO:0006613 cotranslational protein targeting to membrane 16/1036 109/18670 0.0003304 0.01402 0.01238 RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/RPL36 16 GO:0019882 antigen processing and presentation 26/1036 226/18670 0.0003481 0.01465 0.01294 HLA-DRB4/KIF2A/PSMA2/CTSD/HLA-DQB1/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/CD8A/HLA-DOB/PSME4/WAS/PSMD12/KIFAP3/CD1A/RFTN1/PSMB1/PSMD10/AP2B1/DCTN6/PSMC5/SEC24A/PSMA3/ATG5 26 GO:0009144 purine nucleoside triphosphate metabolic process 35/1036 342/18670 0.0003655 0.01521 0.01343 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NUP205/NDUFA4/MFN1/MSH2/NDUFA6/NDUFB4/DNM1L/CYC1/NUP85/ATP1B1/SPHK2/HDAC4/PFKP/NCOR1/NDUFS1/NUP160/NDUFS4/OLA1/NUP214/COQ9/ZBTB7A 35 GO:0090175 regulation of establishment of planar polarity 16/1036 110/18670 0.0003672 0.01521 0.01343 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PSMB1/PSMD10/ROR1/AP2B1/PSMC5/FZD2/PSMA3 16 GO:0019080 viral gene expression 23/1036 191/18670 0.0003906 0.01606 0.01418 CCL5/NUP107/NUP37/ZFP36/RPL6/RPS7/RPS5/NUP205/RPL35/RPS4Y1/USF2/RPL35A/NUP85/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/NUP160/RPL36/NUP214 23 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 11/1036 60/18670 0.0004073 0.01655 0.01461 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 11 GO:0072599 establishment of protein localization to endoplasmic reticulum 17/1036 122/18670 0.0004087 0.01655 0.01461 RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/RPL36/SPCS1 17 GO:0038093 Fc receptor signaling pathway 27/1036 241/18670 0.0004135 0.01662 0.01467 CD247/NFKB1/SOS1/SKP1/MALT1/NCK1/PSMA2/PRKCQ/PSMA5/PSMD14/PSMA1/PSMC2/FYN/PSME4/WAS/ITK/PSMD12/CYFIP2/PIK3CA/MAPK3/ELMO2/PSMB1/PSMD10/CUL1/PIK3R1/PSMC5/PSMA3 27 GO:1901796 regulation of signal transduction by p53 class mediator 22/1036 180/18670 0.0004212 0.01673 0.01477 DYRK2/BRD7/TOPBP1/RBBP4/RPS7/CSNK2A2/EEF1E1/ATR/STK11/TBP/DYRK3/RBBP7/PSMD10/RRS1/TAF5/DYRK1A/UBB/PMAIP1/RPL11/RPA1/TRIM24/TAF12 22 GO:0007566 embryo implantation 10/1036 51/18670 0.0004225 0.01673 0.01477 TGFBR2/IL1B/C1QBP/UBE2Q1/POLR1B/RECK/EMP2/LIF/RPL29/SOD1 10 GO:0090150 establishment of protein localization to membrane 34/1036 332/18670 0.000435 0.01709 0.01509 OPTN/ZDHHC4/MOAP1/NPC1/GZMB/FYN/RPL6/SRP72/RPS7/GORASP2/RPS5/RPL35/YWHAQ/RPS4Y1/OXA1L/TRAM1/RPL35A/ATP1B1/UBA52/RFTN1/ANXA13/RPL19/C16orf70/RPL29/VPS37B/AGK/RPL15/RPS21/PMAIP1/RPL11/ACSL3/MFF/RPL22/RPL36 34 GO:0042089 cytokine biosynthetic process 17/1036 123/18670 0.0004503 0.01748 0.01543 IL1A/NFKB1/IL6/IFNG/IL1B/PRKCQ/IL12B/ZFP36/TNF/TIA1/TRIB2/TLR3/ELANE/TLR6/CD3E/UBE2J1/LBP 17 GO:0038095 Fc-epsilon receptor signaling pathway 21/1036 169/18670 0.0004514 0.01748 0.01543 NFKB1/SOS1/SKP1/MALT1/PSMA2/PRKCQ/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/ITK/PSMD12/PIK3CA/MAPK3/PSMB1/PSMD10/CUL1/PIK3R1/PSMC5/PSMA3 21 GO:0030656 regulation of vitamin metabolic process 5/1036 13/18670 0.0004611 0.01773 0.01565 NFKB1/IFNG/IL1B/TNF/AKR1C3 5 GO:0002287 alpha-beta T cell activation involved in immune response 11/1036 61/18670 0.0004723 0.0179 0.01581 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 11 GO:0002293 alpha-beta T cell differentiation involved in immune response 11/1036 61/18670 0.0004723 0.0179 0.01581 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 11 GO:0033238 regulation of cellular amine metabolic process 13/1036 81/18670 0.000489 0.01813 0.01601 ABAT/PSMA2/ODC1/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 13 GO:0019884 antigen processing and presentation of exogenous antigen 22/1036 182/18670 0.000491 0.01813 0.01601 HLA-DRB4/KIF2A/PSMA2/CTSD/HLA-DQB1/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/HLA-DOB/PSME4/PSMD12/KIFAP3/CD1A/PSMB1/PSMD10/AP2B1/DCTN6/PSMC5/SEC24A/PSMA3 22 GO:0042273 ribosomal large subunit biogenesis 12/1036 71/18670 0.000492 0.01813 0.01601 ZNHIT3/ZNHIT6/RPL6/MDN1/RPL35/NPM1/RPL35A/RSL24D1/RRS1/RPL11/WDR12/GTF3A 12 GO:0042107 cytokine metabolic process 17/1036 124/18670 0.0004954 0.01813 0.01601 IL1A/NFKB1/IL6/IFNG/IL1B/PRKCQ/IL12B/ZFP36/TNF/TIA1/TRIB2/TLR3/ELANE/TLR6/CD3E/UBE2J1/LBP 17 GO:0046717 acid secretion 17/1036 124/18670 0.0004954 0.01813 0.01601 ABAT/IL1B/CHRM5/KMO/NTSR1/SV2A/ANXA1/HRH2/TRH/CCKBR/ABCC4/PLA2G3/KCNQ1/NMU/SLC38A2/CYP4A11/SLC1A3 17 GO:0006732 coenzyme metabolic process 39/1036 403/18670 0.000534 0.01941 0.01714 CD38/PDSS1/MDH1/PGK1/NUP107/IFNG/LDHB/SUCLA2/DERA/SLC25A32/NUP37/DLD/KMO/PDHX/GCLC/NNT/PPCS/NUP205/QDPR/AHCY/SUCLG2/GPD1L/NUP85/SLC22A13/MCCC1/KYNU/HDAC4/SUCLG1/PFKP/CYB5A/AASDHPPT/ACSL3/PDHB/NCOR1/NUP160/ACAT1/NUP214/COQ9/ZBTB7A 39 GO:0032623 interleukin-2 production 11/1036 62/18670 0.0005458 0.01958 0.01729 CD247/IL1A/IL1B/MALT1/PRKCQ/ZFP36/PDE4B/ANXA1/TBX21/CD83/CD3E 11 GO:0046635 positive regulation of alpha-beta T cell activation 11/1036 62/18670 0.0005458 0.01958 0.01729 IFNG/TGFBR2/MALT1/PRKCQ/IL12B/ANXA1/IL23A/RARA/CD83/ZBTB16/CD3E 11 GO:1902036 regulation of hematopoietic stem cell differentiation 12/1036 72/18670 0.0005611 0.01999 0.01765 PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 12 GO:0039529 RIG-I signaling pathway 6/1036 20/18670 0.000569 0.02014 0.01778 C1QBP/BIRC3/DDX60/ANKRD17/PUM1/GPATCH3 6 GO:0050684 regulation of mRNA processing 18/1036 137/18670 0.0005777 0.02031 0.01793 TRA2B/SRSF8/CTR9/C1QBP/SRSF10/SART3/TIA1/NUDT21/RBM15/HNRNPA2B1/RBM15B/PRDX6/DYRK1A/KHDRBS2/RBM25/RBM7/RBM8A/ZBTB7A 18 GO:0018393 internal peptidyl-lysine acetylation 20/1036 161/18670 0.0006128 0.0214 0.0189 AUTS2/BRD7/HAT1/IL1B/FLCN/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/ATAT1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 20 GO:0070482 response to oxygen levels 38/1036 394/18670 0.000667 0.02314 0.02044 CD38/MYC/ABAT/PGK1/TGFBR2/RORA/PSMA2/CAT/HSD11B2/PLOD1/SOD3/PSMA5/PSMD14/PSMA1/PSMC2/SCFD1/RBX1/TGFBR3/CXCR4/PSME4/PSMD12/PHB2/CHCHD2/DNM1L/ADSL/AHCY/TRH/ATP1B1/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/ADAM15/CA9/PSMC5/PSMA3 38 GO:0032663 regulation of interleukin-2 production 10/1036 54/18670 0.0006806 0.02341 0.02067 IL1A/IL1B/MALT1/PRKCQ/ZFP36/PDE4B/ANXA1/TBX21/CD83/CD3E 10 GO:0050863 regulation of T cell activation 32/1036 314/18670 0.0006875 0.02341 0.02067 DROSHA/SOS1/CCL5/IL6/IFNG/TGFBR2/CD2/IL1B/MALT1/NCK1/PRKCQ/IL12B/ICOS/FYN/PTPN22/ANXA1/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ZBTB16/IL15/SOD1/CD3E/LILRB4/PIK3R1/EFNB3/CLC 32 GO:0045580 regulation of T cell differentiation 18/1036 139/18670 0.0006877 0.02341 0.02067 DROSHA/SOS1/IFNG/TGFBR2/CD2/MALT1/IL12B/ANXA1/RASGRP1/TBX21/XBP1/IL23A/RARA/CD83/ZBTB16/IL15/SOD1/LILRB4 18 GO:0034504 protein localization to nucleus 28/1036 262/18670 0.0006957 0.0235 0.02075 PARP1/NUP107/IFNG/CCT7/FLCN/SKP1/SUPT7L/CBLB/RANBP6/FYN/CCT2/CD2AP/PHB2/SYNE1/NUP85/LIF/STK11/CSE1L/ZBTB16/RRS1/RPL11/TOR1AIP1/LILRB4/PIK3R1/SIX2/NUP214/IPO7/ZBTB7A 28 GO:0002718 regulation of cytokine production involved in immune response 13/1036 84/18670 0.0006992 0.0235 0.02075 CD96/IL6/IL1B/MALT1/TNF/DDX1/DDX21/TBX21/TLR3/RSAD2/MAPK3/CLC/ATG5 13 GO:0002478 antigen processing and presentation of exogenous peptide antigen 21/1036 175/18670 0.0007183 0.02399 0.02119 HLA-DRB4/KIF2A/PSMA2/CTSD/HLA-DQB1/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/HLA-DOB/PSME4/PSMD12/KIFAP3/PSMB1/PSMD10/AP2B1/DCTN6/PSMC5/SEC24A/PSMA3 21 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 14/1036 95/18670 0.0007328 0.02431 0.02146 SKP1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PSMB1/PSMD10/CUL1/PSMC5/PSMA3 14 GO:0022904 respiratory electron transport chain 16/1036 117/18670 0.0007369 0.02431 0.02146 DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NDUFA4/NDUFA6/NDUFB4/CYC1/ETFA/NDUFS1/NDUFS4/COQ9 16 GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 6/1036 21/18670 0.0007595 0.0249 0.02199 C1QBP/BIRC3/DDX60/ANKRD17/PUM1/GPATCH3 6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 10/1036 55/18670 0.0007911 0.02578 0.02276 DLD/NDUFV1/NDUFV2/NDUFA10/NDUFA4/NDUFA6/NDUFB4/NDUFS1/NDUFS4/COQ9 10 GO:1903037 regulation of leukocyte cell-cell adhesion 31/1036 304/18670 0.0008187 0.02645 0.02336 CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/ITGA4/PRKCQ/IL12B/ICOS/FYN/TNF/PTPN22/ANXA1/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ELANE/ZBTB16/IL15/CCL25/CD3E/LILRB4/PIK3R1/EFNB3 31 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 11/1036 65/18670 0.0008259 0.02645 0.02336 TRA2B/SRSF8/SRSF10/SART3/RBM15/RBM15B/DYRK1A/RBM25/RBM7/RBM8A/ZBTB7A 11 GO:0071826 ribonucleoprotein complex subunit organization 30/1036 291/18670 0.0008266 0.02645 0.02336 ZNHIT3/ZNHIT6/C1QBP/EIF4B/SRSF10/SNRPD1/SART3/RPL6/ZFAND1/RPS5/MTIF2/MDN1/DDX1/CLNS1A/NUDT21/ATR/COIL/NPM1/PRPF8/DYRK3/RSL24D1/MRPL22/SNRPF/RRS1/SNRPD2/EIF5/SETX/RPL11/PWP2/SHQ1 30 GO:0072538 T-helper 17 type immune response 7/1036 29/18670 0.0008437 0.02684 0.0237 IL6/MALT1/RORA/PRKCQ/IL12B/TBX21/IL23A 7 GO:2000027 regulation of animal organ morphogenesis 27/1036 253/18670 0.0008776 0.02775 0.0245 MYC/TGFBR2/DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/MAGED1/ACVR1/TNF/PSME4/PSMD12/PHB2/MLLT3/XBP1/SULF1/LIF/PSMB1/CITED2/PSMD10/ROR1/AP2B1/PSMC5/SIX2/FZD2/PSMA3 27 GO:0002244 hematopoietic progenitor cell differentiation 20/1036 166/18670 0.0009043 0.02826 0.02495 SOS1/FLCN/C12orf29/PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/WDR7/HERC6/PSMD12/NUDT21/PSMB1/SPI1/PSMD10/RRS1/PSMC5/PSMA3 20 GO:0006475 internal protein amino acid acetylation 20/1036 166/18670 0.0009043 0.02826 0.02495 AUTS2/BRD7/HAT1/IL1B/FLCN/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/ATAT1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 20 GO:0072331 signal transduction by p53 class mediator 28/1036 267/18670 0.0009335 0.029 0.02561 PCNA/DYRK2/HINT1/BRD7/TOPBP1/RBBP4/BTG2/RPS7/CSNK2A2/MSH2/EEF1E1/ATR/STK11/TBP/DYRK3/RBBP7/PSMD10/RRS1/TAF5/DYRK1A/UBB/PMAIP1/RPL11/ATRX/RPA1/TRIM24/TAF12/EDA2R 28 GO:0050900 leukocyte migration 45/1036 499/18670 0.0009392 0.02901 0.02562 CXCL11/SOS1/CCL5/IL6/CD2/IL1B/C1QBP/GPR18/MADCAM1/ITGA4/ITGA6/CD244/FYN/CHGA/PDE4B/TNF/TRPM2/CXCR4/IL36A/DAPK2/ANXA1/ARTN/TBX21/SLC7A5/LCK/CD48/IL23A/PIK3CA/NUP85/MAPK3/ATP1B1/ELANE/AIMP1/CH25H/CD99/CCL11/PTGER4/CD9/GPR183/CCL25/CCL23/SLAMF8/PIK3R1/BCR/LBP 45 GO:2001235 positive regulation of apoptotic signaling pathway 21/1036 179/18670 0.0009642 0.0294 0.02596 SFPQ/FLCN/MOAP1/NCK1/CTSC/GZMB/BCLAF1/MAGED1/ATF3/RPS7/BMPR1B/YWHAQ/PRKRA/DNM1L/LCK/PIAS4/UBB/PMAIP1/RPL11/SOD1/MFF 21 GO:0045058 T cell selection 9/1036 47/18670 0.000973 0.0294 0.02596 IL6/IL12B/TBX21/BCL11B/IL23A/STK11/IL15/CD3E/ATG5 9 GO:0046638 positive regulation of alpha-beta T cell differentiation 9/1036 47/18670 0.000973 0.0294 0.02596 IFNG/TGFBR2/MALT1/IL12B/ANXA1/IL23A/RARA/CD83/ZBTB16 9 GO:0010948 negative regulation of cell cycle process 35/1036 361/18670 0.0009736 0.0294 0.02596 PCNA/NAE1/BRD7/SKP1/DACT1/TOPBP1/PSMA2/RBBP4/PSMA5/PSMD14/BTG2/PSMA1/TRIM37/PSMC2/RBX1/PSMG2/PSME4/PSMD12/YAF2/NPM1/NDC80/LIF/UXT/TNKS/PSMB1/FBXO5/RBBP7/PSMD10/CUL1/ATRX/TERF1/DONSON/PSMC5/CDC7/PSMA3 35 GO:1901990 regulation of mitotic cell cycle phase transition 41/1036 444/18670 0.0009881 0.02967 0.0262 PCNA/NAE1/BRD7/CEP57/SKP1/DACT1/TOPBP1/CDC23/CDC25B/PSMA2/ANAPC5/PSMA5/PSMD14/BTG2/DYNLL1/PSMA1/PSMC2/RBX1/PSMG2/ANKRD17/PSME4/ANXA1/PSMD12/PHB2/SMARCD3/NDC80/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/RIOK2/CLASP1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/CDC7/TMEM14B/PSMA3 41 GO:1901798 positive regulation of signal transduction by p53 class mediator 6/1036 22/18670 0.0009957 0.02973 0.02625 RPS7/EEF1E1/ATR/UBB/PMAIP1/RPL11 6 GO:0043624 cellular protein complex disassembly 24/1036 217/18670 0.001011 0.03002 0.02651 KIF2A/GSPT2/PTCD3/MRPL42/ADD3/MRPS30/MICAL1/CKAP2/MRPL9/OXA1L/MRPS17/MRPS28/TRMT112/MRPL52/MRPL39/CLASP1/MRPL22/MRPS33/MRPL19/GSPT1/MRPS14/MRPL28/SH3BP1/MRPL16 24 GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 7/1036 30/18670 0.001048 0.03095 0.02733 IFNG/MALT1/IL12B/ANXA1/IL23A/RARA/CD83 7 GO:0016573 histone acetylation 19/1036 156/18670 0.001054 0.03095 0.02733 AUTS2/BRD7/HAT1/IL1B/FLCN/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 19 GO:0006414 translational elongation 17/1036 133/18670 0.001109 0.03238 0.02859 PTCD3/MRPL42/EIF4A3/MRPS30/USP16/MRPL9/OXA1L/MRPS17/MRPS28/MRPL52/MRPL39/MRPL22/MRPS33/MRPL19/MRPS14/MRPL28/MRPL16 17 GO:0018394 peptidyl-lysine acetylation 20/1036 169/18670 0.001131 0.03267 0.02885 AUTS2/BRD7/HAT1/IL1B/FLCN/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/ATAT1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 20 GO:0045619 regulation of lymphocyte differentiation 20/1036 169/18670 0.001131 0.03267 0.02885 DROSHA/SOS1/IFNG/TGFBR2/CD2/MALT1/IL12B/ANXA1/RASGRP1/TBX21/XBP1/IL23A/RARA/CD83/ZBTB16/IL15/SOD1/LILRB4/SLAMF8/PGLYRP4 20 GO:0006766 vitamin metabolic process 17/1036 134/18670 0.001206 0.03456 0.03052 NFKB1/IFNG/IL1B/SLC25A32/KMO/MTR/GCLC/TNF/PIAS4/MCCC1/KYNU/AKR1C3/LMBRD1/CYB5A/AASDHPPT/TCN2/CYP4F12 17 GO:0042093 T-helper cell differentiation 10/1036 58/18670 0.001214 0.03456 0.03052 IL6/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 10 GO:0002292 T cell differentiation involved in immune response 11/1036 68/18670 0.001216 0.03456 0.03052 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 11 GO:1902105 regulation of leukocyte differentiation 28/1036 272/18670 0.001239 0.03504 0.03094 DROSHA/MYC/SOS1/IFNG/TGFBR2/CD2/MALT1/GNAS/IL12B/TNF/ANXA1/RASGRP1/TBX21/TLR3/XBP1/IL23A/RARA/LILRB3/LIF/CD83/ZBTB16/IL15/HAX1/SOD1/LILRB4/SLAMF8/PIK3R1/PGLYRP4 28 GO:0002696 positive regulation of leukocyte activation 36/1036 380/18670 0.001253 0.03526 0.03113 CD38/CCL5/IL6/IFNG/TGFBR2/CD2/IL1B/MALT1/NCK1/CTSC/TNFSF13/PRKCQ/IL12B/ICOS/FYN/ANXA1/MSH2/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/SPHK2/GPR183/TLR6/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/TRBC1/EFNB3/LBP 36 GO:0009124 nucleoside monophosphate biosynthetic process 23/1036 208/18670 0.001278 0.03575 0.03157 PARP1/PGK1/NUP107/IFNG/PRPS2/DCK/FLCN/CMPK1/NUP37/PRPS1/NUP205/UCKL1/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/APRT/NCOR1/NUP160/NUP214/ZBTB7A 23 GO:0010499 proteasomal ubiquitin-independent protein catabolic process 6/1036 23/18670 0.001284 0.03575 0.03157 PSMA2/PSMA5/PSMA1/PSME4/PSMB1/PSMA3 6 GO:0070972 protein localization to endoplasmic reticulum 18/1036 147/18670 0.001326 0.03673 0.03243 INSIG1/RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/RPL15/RPS21/RPL11/RPL22/RPL36/SPCS1 18 GO:1901987 regulation of cell cycle phase transition 43/1036 480/18670 0.001373 0.03749 0.0331 PCNA/NAE1/BRD7/CEP57/SKP1/DACT1/TOPBP1/CDC23/CDC25B/PSMA2/ANAPC5/PSMA5/PSMD14/BTG2/DYNLL1/PSMA1/PSMC2/RBX1/PSMG2/ANKRD17/PSME4/ANXA1/PSMD12/PHB2/SMARCD3/NPM1/NDC80/PRKAR2B/HAUS2/PCM1/PSMB1/CEP76/RIOK2/DYRK3/CLASP1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/CDC7/TMEM14B/PSMA3 43 GO:0019835 cytolysis 8/1036 40/18670 0.001374 0.03749 0.0331 LYZ/PRF1/GZMB/GZMA/C8B/MMD/PGLYRP4/LBP 8 GO:0001736 establishment of planar polarity 16/1036 124/18670 0.001386 0.03749 0.0331 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PSMB1/PSMD10/ROR1/AP2B1/PSMC5/FZD2/PSMA3 16 GO:0007164 establishment of tissue polarity 16/1036 124/18670 0.001386 0.03749 0.0331 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PSMB1/PSMD10/ROR1/AP2B1/PSMC5/FZD2/PSMA3 16 GO:0006417 regulation of translation 39/1036 424/18670 0.001394 0.03749 0.0331 CCL5/IL6/C1QBP/EIF4B/NCK1/PASK/PTCD3/METAP1/EIF4A3/FASTKD3/BTG2/ZFP36/USP16/TNF/CAPRIN2/NGRN/TIA1/MTIF2/PAIP1/DDX1/CDK5RAP1/HNRNPR/NPM1/UPF3A/ELAVL1/PUM1/RARA/MAPK3/PABPC1/ZNF706/CAPRIN1/EIF5/RPL22/RPS6KA3/CNBP/KHSRP/RBM8A/UPF3B/FXR1 39 GO:0051091 positive regulation of DNA-binding transcription factor activity 27/1036 261/18670 0.001396 0.03749 0.0331 ARID5B/NFKB1/IL6/IL1B/PRKCH/MALT1/CAT/PRKCQ/CRTC3/GTF2A2/TRIM37/TNF/TRAF5/RWDD1/PHB2/PPRC1/TLR3/NPM1/UBA52/HDAC4/TLR6/UBB/ROR1/TAF12/FZD2/EDA2R/ZBTB7A 27 GO:0009156 ribonucleoside monophosphate biosynthetic process 22/1036 197/18670 0.001418 0.03789 0.03346 PARP1/PGK1/NUP107/IFNG/PRPS2/FLCN/CMPK1/NUP37/PRPS1/NUP205/UCKL1/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/APRT/NCOR1/NUP160/NUP214/ZBTB7A 22 GO:0045638 negative regulation of myeloid cell differentiation 13/1036 91/18670 0.001499 0.03984 0.03518 MYC/GPR171/CTR9/HSPA9/ZFP36/TLR3/RARA/LILRB3/RBM15/ZBTB16/LILRB4/PIK3R1/NCAPG2 13 GO:0001787 natural killer cell proliferation 4/1036 10/18670 0.001511 0.03999 0.03531 IL12B/PTPN22/IL23A/IL15 4 GO:0006913 nucleocytoplasmic transport 33/1036 343/18670 0.001521 0.04005 0.03536 NUP107/IFNG/IL1B/BACH2/MALT1/NUP37/HSPA9/EIF4A3/SNRPD1/CBLB/RANBP6/PPP1CC/NUP205/PHB2/NPM1/UPF3A/NUP85/HNRNPA2B1/RIOK2/CSE1L/RBM15B/SNRPF/RRS1/CDC40/SNRPD2/NUP160/PIK3R1/SIX2/NUP214/RBM8A/UPF3B/STRADA/IPO7 33 GO:0002407 dendritic cell chemotaxis 6/1036 24/18670 0.001633 0.04263 0.03764 CCL5/C1QBP/TRPM2/CXCR4/GPR183/SLAMF8 6 GO:0001510 RNA methylation 12/1036 81/18670 0.001635 0.04263 0.03764 TFB2M/FBL/EMG1/TARBP1/TRMT61B/MTO1/RBM15/TRMT5/TRMT112/RBM15B/DIMT1/CBLL1 12 GO:0035567 non-canonical Wnt signaling pathway 18/1036 150/18670 0.00167 0.04333 0.03826 DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PLCB3/PSMB1/PSMD10/ROR1/AP2B1/PSMC5/FZD2/PSMA3 18 GO:0051169 nuclear transport 33/1036 346/18670 0.001754 0.04529 0.03999 NUP107/IFNG/IL1B/BACH2/MALT1/NUP37/HSPA9/EIF4A3/SNRPD1/CBLB/RANBP6/PPP1CC/NUP205/PHB2/NPM1/UPF3A/NUP85/HNRNPA2B1/RIOK2/CSE1L/RBM15B/SNRPF/RRS1/CDC40/SNRPD2/NUP160/PIK3R1/SIX2/NUP214/RBM8A/UPF3B/STRADA/IPO7 33 GO:0002700 regulation of production of molecular mediator of immune response 17/1036 139/18670 0.001806 0.04618 0.04078 CD96/IL6/IL1B/MALT1/TNFSF13/CD244/TNF/DDX1/MSH2/DDX21/TBX21/TLR3/XBP1/RSAD2/MAPK3/CLC/ATG5 17 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 10/1036 61/18670 0.001806 0.04618 0.04078 IFNG/TGFBR2/MALT1/PRKCQ/IL12B/ANXA1/TBX21/IL23A/RARA/CD83 10 GO:0031649 heat generation 5/1036 17/18670 0.001841 0.0464 0.04097 ABAT/IL1A/IL1B/TNF/NMU 5 GO:0032740 positive regulation of interleukin-17 production 5/1036 17/18670 0.001841 0.0464 0.04097 IL6/PRKCQ/IL12B/IL23A/IL15 5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process 5/1036 17/18670 0.001841 0.0464 0.04097 TRMT61B/CDK5RAP1/MTO1/TRMT5/TPRKB 5 GO:0022407 regulation of cell-cell adhesion 37/1036 403/18670 0.001883 0.04724 0.04171 ABAT/CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/ITGA4/PRKCQ/ITGA6/IL12B/ICOS/FYN/TNF/PTPN22/ANXA1/KIFAP3/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/MBP/PIK3CA/CD83/ELANE/CD9/CITED2/ZBTB16/IL15/CCL25/CD3E/LILRB4/PIK3R1/EFNB3 37 GO:0048002 antigen processing and presentation of peptide antigen 21/1036 189/18670 0.001915 0.04782 0.04223 HLA-DRB4/KIF2A/PSMA2/CTSD/HLA-DQB1/PSMA5/PSMD14/DYNLL1/PSMA1/PSMC2/HLA-DOB/PSME4/PSMD12/KIFAP3/PSMB1/PSMD10/AP2B1/DCTN6/PSMC5/SEC24A/PSMA3 21 GO:0051028 mRNA transport 18/1036 152/18670 0.001939 0.0482 0.04256 NUP107/NUP37/EIF4A3/ZFP36/NUP205/UPF3A/PARP11/NUP85/TNKS/HNRNPA2B1/RBM15B/CDC40/LUZP4/NUP160/KHSRP/NUP214/RBM8A/UPF3B 18 GO:1901293 nucleoside phosphate biosynthetic process 36/1036 390/18670 0.001964 0.04859 0.04291 PARP1/PGK1/NUP107/IFNG/PRPS2/DCK/AK6/FLCN/CMPK1/NUP37/DLD/KMO/PDHX/PRPS1/PPCS/NUP205/UCKL1/ADSL/CYC1/NUP85/SLC22A13/SPHK2/KYNU/HDAC4/AGPAT2/SUCLG1/PFKP/PRPSAP2/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 36 GO:0045621 positive regulation of lymphocyte differentiation 13/1036 94/18670 0.002021 0.04931 0.04354 IFNG/TGFBR2/MALT1/IL12B/ANXA1/RASGRP1/XBP1/IL23A/RARA/CD83/ZBTB16/IL15/LILRB4 13 GO:0045582 positive regulation of T cell differentiation 12/1036 83/18670 0.002023 0.04931 0.04354 IFNG/TGFBR2/MALT1/IL12B/ANXA1/RASGRP1/XBP1/IL23A/RARA/CD83/ZBTB16/LILRB4 12 GO:0060218 hematopoietic stem cell differentiation 12/1036 83/18670 0.002023 0.04931 0.04354 PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 12 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 10/1036 62/18670 0.002048 0.04931 0.04354 C1QBP/BIRC3/PTPN22/DDX60/ANKRD17/PUM1/UBA52/ALPK1/UBB/GPATCH3 10 GO:0002335 mature B cell differentiation 6/1036 25/18670 0.002049 0.04931 0.04354 ITM2A/POU2F2/MALT1/XBP1/GPR183/SLAMF8 6 GO:2000482 regulation of interleukin-8 secretion 6/1036 25/18670 0.002049 0.04931 0.04354 CD2/CD244/PTPN22/ANXA1/TLR6/FCN1 6 GO:0018209 peptidyl-serine modification 31/1036 322/18670 0.002058 0.04931 0.04354 PARP1/DYRK2/IL6/IFNG/TGFBR2/PRKCH/NCK1/AURKC/PRKCQ/PRKACB/POGLUT1/STK38/PLCL1/TNF/CAPRIN2/CSNK2A2/MAST3/PRKX/ATR/PIK3CA/GPD1L/MAPK3/LIF/TNKS/VRK1/DYRK3/DYRK1A/HAX1/PAQR3/RPS6KA3/CDC7 31 GO:0044106 cellular amine metabolic process 16/1036 129/18670 0.0021 0.04983 0.044 ABAT/PSMA2/ODC1/KMO/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/TRH/KYNU/PSMB1/PSMD10/PSMC5/PSMA3 16 GO:0001738 morphogenesis of a polarized epithelium 17/1036 141/18670 0.002107 0.04983 0.044 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/MLLT3/PSMB1/PSMD10/ROR1/AP2B1/SH3BP1/PSMC5/FZD2/PSMA3 17 GO:0097530 granulocyte migration 17/1036 141/18670 0.002107 0.04983 0.044 CXCL11/CCL5/IL1B/C1QBP/PDE4B/IL36A/DAPK2/ANXA1/IL23A/MAPK3/CD99/CCL11/PTGER4/CCL25/CCL23/SLAMF8/LBP 17 GO:2001233 regulation of apoptotic signaling pathway 37/1036 406/18670 0.00214 0.05037 0.04448 PARP1/IL1A/IL1B/SFPQ/FLCN/MOAP1/NCK1/CTSC/ITGA6/SLC25A5/GZMB/BCLAF1/MAGED1/GCLC/ACVR1/FYN/TNF/SIAH2/ATF3/RPS7/BMPR1B/DAPK2/CSNK2A2/YWHAQ/PRKRA/DNM1L/LCK/XBP1/PIAS4/PSMD10/UBB/PMAIP1/RPL11/SOD1/ZMYND11/MFF/SLC35F6 37 GO:0007159 leukocyte cell-cell adhesion 32/1036 337/18670 0.002189 0.05132 0.04531 CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/MADCAM1/ITGA4/PRKCQ/IL12B/ICOS/FYN/TNF/PTPN22/ANXA1/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/ELANE/ZBTB16/IL15/CCL25/CD3E/LILRB4/PIK3R1/EFNB3 32 GO:0009266 response to temperature stimulus 25/1036 243/18670 0.002218 0.05169 0.04564 IL1A/NUP107/NUP37/HSPA9/ATP2A2/GCLC/NTSR1/SLC12A5/TRPM2/TMEM135/CXCR4/NUP205/DNAJB1/ATR/TRH/NUP85/MAPK3/HSPA14/RBBP7/DAXX/SOD1/RPA1/NUP160/ZNF516/NUP214 25 GO:0036294 cellular response to decreased oxygen levels 23/1036 217/18670 0.00223 0.05169 0.04564 MYC/PGK1/RORA/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PHB2/CHCHD2/DNM1L/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/CA9/PSMC5/PSMA3 23 GO:0002517 T cell tolerance induction 4/1036 11/18670 0.002271 0.05169 0.04564 TGFBR2/ICOS/CD3E/CLC 4 GO:0031652 positive regulation of heat generation 4/1036 11/18670 0.002271 0.05169 0.04564 ABAT/IL1B/TNF/NMU 4 GO:1901569 fatty acid derivative catabolic process 4/1036 11/18670 0.002271 0.05169 0.04564 OXCT1/CYP4A11/ACAT1/CYP4F12 4 GO:2000318 positive regulation of T-helper 17 type immune response 4/1036 11/18670 0.002271 0.05169 0.04564 MALT1/PRKCQ/IL12B/IL23A 4 GO:0043368 positive T cell selection 7/1036 34/18670 0.002283 0.05169 0.04564 IL6/IL12B/TBX21/BCL11B/IL23A/STK11/CD3E 7 GO:0097009 energy homeostasis 7/1036 34/18670 0.002283 0.05169 0.04564 FLCN/PASK/CRTC3/MEX3C/PIK3CA/UBB/NMU 7 GO:0042255 ribosome assembly 10/1036 63/18670 0.002316 0.05195 0.04587 C1QBP/RPL6/RPS5/MDN1/NPM1/RSL24D1/MRPL22/RRS1/RPL11/PWP2 10 GO:0046637 regulation of alpha-beta T cell differentiation 10/1036 63/18670 0.002316 0.05195 0.04587 IFNG/TGFBR2/MALT1/IL12B/ANXA1/TBX21/IL23A/RARA/CD83/ZBTB16 10 GO:0050867 positive regulation of cell activation 36/1036 394/18670 0.002334 0.05195 0.04587 CD38/CCL5/IL6/IFNG/TGFBR2/CD2/IL1B/MALT1/NCK1/CTSC/TNFSF13/PRKCQ/IL12B/ICOS/FYN/ANXA1/MSH2/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/SPHK2/GPR183/TLR6/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/TRBC1/EFNB3/LBP 36 GO:0035065 regulation of histone acetylation 9/1036 53/18670 0.00235 0.05195 0.04587 AUTS2/BRD7/IL1B/FLCN/MAPK3/LIF/SPHK2/SPI1/ATG5 9 GO:0043331 response to dsRNA 9/1036 53/18670 0.00235 0.05195 0.04587 NFKB1/DDX1/DDX21/TLR3/NPM1/MAPK3/RFTN1/PMAIP1/PQBP1 9 GO:0098781 ncRNA transcription 14/1036 107/18670 0.002358 0.05195 0.04587 POU2F2/GTF3C3/INTS12/GTF2A2/NOL11/POLR1B/INTS8/USPL1/ICE1/TBP/ICE2/TAF5/GTF2E1/GTF3A 14 GO:1903320 regulation of protein modification by small protein conjugation or removal 24/1036 231/18670 0.002362 0.05195 0.04587 RCHY1/CTR9/MALT1/TOLLIP/DERL1/SART3/GCLC/FYN/CRY1/BIRC3/SIAH2/PTPN22/TRIM44/RPS7/DNM1L/PIAS4/HDAC4/FBXO5/HMG20A/PSMD10/DAXX/UBB/RPL11/ATG5 24 GO:2001169 regulation of ATP biosynthetic process 13/1036 96/18670 0.002446 0.05345 0.0472 PARP1/NUP107/IFNG/FLCN/NUP37/NUP205/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0032677 regulation of interleukin-8 production 11/1036 74/18670 0.00245 0.05345 0.0472 CD2/IL1B/CD244/TNF/PTPN22/ANXA1/TLR3/ELANE/TLR6/FCN1/LBP 11 GO:0018105 peptidyl-serine phosphorylation 29/1036 299/18670 0.002527 0.05489 0.04847 DYRK2/IL6/IFNG/TGFBR2/PRKCH/NCK1/AURKC/PRKCQ/PRKACB/STK38/PLCL1/TNF/CAPRIN2/CSNK2A2/MAST3/PRKX/ATR/PIK3CA/GPD1L/MAPK3/LIF/TNKS/VRK1/DYRK3/DYRK1A/HAX1/PAQR3/RPS6KA3/CDC7 29 GO:0072539 T-helper 17 cell differentiation 6/1036 26/18670 0.00254 0.05496 0.04853 IL6/MALT1/RORA/IL12B/TBX21/IL23A 6 GO:1902107 positive regulation of leukocyte differentiation 17/1036 144/18670 0.002638 0.05677 0.05013 IFNG/TGFBR2/MALT1/GNAS/IL12B/TNF/ANXA1/RASGRP1/XBP1/IL23A/RARA/LIF/CD83/ZBTB16/IL15/HAX1/LILRB4 17 GO:0046390 ribose phosphate biosynthetic process 29/1036 300/18670 0.002653 0.05677 0.05013 PARP1/PGK1/NUP107/IFNG/PRPS2/FLCN/CMPK1/NUP37/DLD/PDHX/PRPS1/PPCS/NUP205/UCKL1/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/PRPSAP2/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 29 GO:0071456 cellular response to hypoxia 22/1036 207/18670 0.002656 0.05677 0.05013 MYC/PGK1/RORA/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PHB2/CHCHD2/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/CA9/PSMC5/PSMA3 22 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 11/1036 75/18670 0.002731 0.05814 0.05134 PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 11 GO:0031098 stress-activated protein kinase signaling cascade 30/1036 315/18670 0.002829 0.05995 0.05294 AIDA/SLAMF1/MYC/NFKB1/IL1B/SKP1/DACT1/CCDC88C/ZFP36/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP3K19/MAP4K5/MAPK3/UBA52/AKR1B1/PTGER4/MAP4K2/TLR6/IGBP1/CUL1/DAXX/UBB/ZMYND11/NCOR1/STRADA/EDA2R 30 GO:0006119 oxidative phosphorylation 17/1036 145/18670 0.002838 0.05995 0.05294 PGK1/DLD/UQCRB/NDUFV1/CYCS/NDUFV2/COX6C/NDUFA10/SDHA/NDUFA4/MSH2/NDUFA6/NDUFB4/CYC1/NDUFS1/NDUFS4/COQ9 17 GO:0002705 positive regulation of leukocyte mediated immunity 16/1036 133/18670 0.002872 0.06042 0.05335 IL6/SH2D1A/IL1B/MALT1/TNFSF13/IL12B/TNF/DDX1/MSH2/CD1A/DDX21/RASGRP1/TBX21/IL23A/RSAD2/SPHK2 16 GO:1904951 positive regulation of establishment of protein localization 40/1036 456/18670 0.002883 0.06042 0.05336 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/CCT7/OXCT1/GZMB/DYNLL1/CD244/FYN/TNF/PTPN22/CCT2/ZFAND1/CD2AP/CSNK2A2/YWHAQ/LRP1/RASGRP1/DNM1L/XBP1/EDEM1/MBP/TRH/ICE1/MAPK3/PCM1/ANXA13/RIOK2/PTGER4/FCN1/PMAIP1/ACSL3/MFF/NMU/PIK3R1/SEC24A 40 GO:0009165 nucleotide biosynthetic process 35/1036 386/18670 0.003015 0.06294 0.05558 PARP1/PGK1/NUP107/IFNG/PRPS2/DCK/AK6/FLCN/CMPK1/NUP37/DLD/KMO/PDHX/PRPS1/PPCS/NUP205/UCKL1/ADSL/CYC1/NUP85/SLC22A13/SPHK2/KYNU/HDAC4/AGPAT2/PFKP/PRPSAP2/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 35 GO:0006352 DNA-templated transcription, initiation 25/1036 249/18670 0.003075 0.06344 0.05602 NR3C2/GTF3C3/TFB2M/RORA/GTF2A2/MED23/POLR1B/PSMC2/BCLAF1/NR2C1/GTF2H3/CDK8/RARA/MAPK3/TBP/TAF5/SETX/CCNC/ZNF45/TAF1C/MED17/GTF2E1/TAF12/PSMC5/SMARCA5 25 GO:1903578 regulation of ATP metabolic process 15/1036 122/18670 0.003103 0.06344 0.05602 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/DNM1L/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0031167 rRNA methylation 6/1036 27/18670 0.003115 0.06344 0.05602 TFB2M/FBL/EMG1/TRMT61B/TRMT112/DIMT1 6 GO:0036336 dendritic cell migration 6/1036 27/18670 0.003115 0.06344 0.05602 CCL5/C1QBP/TRPM2/CXCR4/GPR183/SLAMF8 6 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 6/1036 27/18670 0.003115 0.06344 0.05602 C1QBP/BIRC3/DDX60/ANKRD17/PUM1/GPATCH3 6 GO:0001696 gastric acid secretion 5/1036 19/18670 0.003153 0.06344 0.05602 CHRM5/HRH2/CCKBR/KCNQ1/NMU 5 GO:0045076 regulation of interleukin-2 biosynthetic process 5/1036 19/18670 0.003153 0.06344 0.05602 IL1A/IL1B/PRKCQ/ZFP36/CD3E 5 GO:0060252 positive regulation of glial cell proliferation 5/1036 19/18670 0.003153 0.06344 0.05602 IL6/IL1B/PRKCH/PPP1CC/TNF 5 GO:0060326 cell chemotaxis 29/1036 304/18670 0.003216 0.06344 0.05602 CXCL11/CCL5/IL6/CCR3/IL1B/C1QBP/GPR18/PRKCQ/CXCR6/CHGA/PDE4B/TRPM2/CXCR4/IL36A/DAPK2/ANXA1/PARVA/IL23A/NUP85/MAPK3/ELMO2/CH25H/CCL11/GPR183/CCL25/FGF18/CCL23/SLAMF8/LBP 29 GO:0000154 rRNA modification 7/1036 36/18670 0.003216 0.06344 0.05602 TFB2M/FBL/EMG1/TRMT61B/THUMPD1/TRMT112/DIMT1 7 GO:0051031 tRNA transport 7/1036 36/18670 0.003216 0.06344 0.05602 NUP107/NUP37/NUP205/NUP85/TOMM20/NUP160/NUP214 7 GO:0043648 dicarboxylic acid metabolic process 13/1036 99/18670 0.003218 0.06344 0.05602 MDH1/SUCLA2/SLC25A32/DLD/KMO/GCLC/SDHA/SUCLG2/KYNU/SUCLG1/FH/GAD2/SLC1A3 13 GO:0022618 ribonucleoprotein complex assembly 27/1036 277/18670 0.003256 0.06344 0.05602 ZNHIT3/ZNHIT6/C1QBP/EIF4B/SRSF10/SNRPD1/SART3/RPL6/RPS5/MDN1/DDX1/CLNS1A/NUDT21/ATR/COIL/NPM1/PRPF8/RSL24D1/MRPL22/SNRPF/RRS1/SNRPD2/EIF5/SETX/RPL11/PWP2/SHQ1 27 GO:0009886 post-embryonic animal morphogenesis 4/1036 12/18670 0.003258 0.06344 0.05602 GNAS/HMGN1/DSCAM/ATRX 4 GO:0042368 vitamin D biosynthetic process 4/1036 12/18670 0.003258 0.06344 0.05602 NFKB1/IFNG/IL1B/TNF 4 GO:0045080 positive regulation of chemokine biosynthetic process 4/1036 12/18670 0.003258 0.06344 0.05602 IFNG/IL1B/TNF/TLR3 4 GO:0072540 T-helper 17 cell lineage commitment 4/1036 12/18670 0.003258 0.06344 0.05602 IL6/IL12B/TBX21/IL23A 4 GO:2000232 regulation of rRNA processing 4/1036 12/18670 0.003258 0.06344 0.05602 TRMT112/RIOK2/DIMT1/SHQ1 4 GO:0090263 positive regulation of canonical Wnt signaling pathway 17/1036 147/18670 0.003276 0.06344 0.05602 NFKB1/DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/RECK/CAPRIN2/PSME4/PSMD12/TNKS/PSMB1/PSMD10/PSMC5/PSMA3 17 GO:0051262 protein tetramerization 19/1036 172/18670 0.003277 0.06344 0.05602 CD247/CRYZ/PDSS1/CCL5/CAT/CRTC3/USP16/TRPM2/CUTC/DNM1L/ADSL/NUDT21/OXA1L/TGM3/KCNC3/PFKP/TRPM6/MCOLN1/TRPM1 19 GO:0030595 leukocyte chemotaxis 23/1036 224/18670 0.003337 0.06438 0.05685 CXCL11/CCL5/IL6/IL1B/C1QBP/GPR18/CHGA/PDE4B/TRPM2/CXCR4/IL36A/DAPK2/ANXA1/IL23A/NUP85/MAPK3/CH25H/CCL11/GPR183/CCL25/CCL23/SLAMF8/LBP 23 GO:0045785 positive regulation of cell adhesion 36/1036 403/18670 0.003391 0.06518 0.05755 CCL5/IL6/IFNG/TGFBR2/IL1B/C1QBP/FLCN/MALT1/NCK1/ITGA4/PRKCQ/ITGA6/IL12B/ICOS/FYN/TNF/ANXA1/KIFAP3/RASGRP1/ARHGEF7/LCK/EMP2/XBP1/IL23A/RARA/PIK3CA/CD83/ELANE/CITED2/ZBTB16/IL15/CCL25/CD3E/LILRB4/PIK3R1/EFNB3 36 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 13/1036 100/18670 0.003516 0.06735 0.05947 IL6/IL1B/MALT1/TNFSF13/PRKCQ/IL12B/TNF/ANXA1/MSH2/CD1A/TBX21/IL23A/RSAD2 13 GO:0071219 cellular response to molecule of bacterial origin 22/1036 212/18670 0.003558 0.0679 0.05996 CXCL11/NFKB1/CCL5/IL6/CTR9/IL1B/MALT1/KMO/IL12B/ZFP36/PDE4B/TNF/PTPN22/IL36A/XBP1/RARA/MAPK3/PRPF8/TLR6/CTSG/BCR/LBP 22 GO:0051251 positive regulation of lymphocyte activation 31/1036 334/18670 0.003586 0.06819 0.06022 CD38/CCL5/IL6/IFNG/TGFBR2/IL1B/MALT1/NCK1/TNFSF13/PRKCQ/IL12B/ICOS/FYN/ANXA1/MSH2/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/GPR183/ZBTB16/IL15/CD3E/LILRB4/PIK3R1/TRBC1/EFNB3 31 GO:0042274 ribosomal small subunit biogenesis 10/1036 67/18670 0.003682 0.06977 0.06161 UTP3/NOL11/EMG1/RPS7/RPS5/NPM1/RIOK2/RRS1/RPS21/PWP2 10 GO:0051092 positive regulation of NF-kappaB transcription factor activity 17/1036 149/18670 0.003769 0.07016 0.06196 NFKB1/IL1B/PRKCH/MALT1/CAT/PRKCQ/TRIM37/TNF/TRAF5/TLR3/NPM1/UBA52/TLR6/UBB/ROR1/EDA2R/ZBTB7A 17 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 7/1036 37/18670 0.00378 0.07016 0.06196 PCNA/PARP1/RBX1/GTF2H3/UBA52/UBB/RPA1 7 GO:0050691 regulation of defense response to virus by host 7/1036 37/18670 0.00378 0.07016 0.06196 IL1B/IL12B/TRIM44/IL23A/APOBEC3G/IL15/PQBP1 7 GO:1904358 positive regulation of telomere maintenance via telomere lengthening 7/1036 37/18670 0.00378 0.07016 0.06196 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1 7 GO:0002691 regulation of cellular extravasation 6/1036 28/18670 0.003781 0.07016 0.06196 ITGA4/ELANE/CD99/PTGER4/CCL25/BCR 6 GO:0070198 protein localization to chromosome, telomeric region 6/1036 28/18670 0.003781 0.07016 0.06196 CCT7/CCT2/ATR/TNKS/ATRX/TERF1 6 GO:0034605 cellular response to heat 16/1036 137/18670 0.003865 0.07146 0.0631 IL1A/NUP107/NUP37/HSPA9/ATP2A2/NUP205/DNAJB1/ATR/NUP85/MAPK3/HSPA14/RBBP7/DAXX/RPA1/NUP160/NUP214 16 GO:0075733 intracellular transport of virus 9/1036 57/18670 0.003915 0.07215 0.06371 NUP107/NUP37/NUP205/NUP85/UBA52/VPS37B/UBB/NUP160/NUP214 9 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 8/1036 47/18670 0.003989 0.07322 0.06466 IFNG/MALT1/IL12B/ANXA1/TBX21/IL23A/RARA/CD83 8 GO:0002703 regulation of leukocyte mediated immunity 21/1036 201/18670 0.004008 0.07322 0.06466 CD96/IL6/SH2D1A/IL1B/MALT1/TNFSF13/IL12B/TNF/WAS/DDX1/MSH2/CD1A/DDX21/RASGRP1/TBX21/TLR3/IL23A/RSAD2/SPHK2/CLC/BCR 21 GO:0070987 error-free translesion synthesis 5/1036 20/18670 0.004015 0.07322 0.06466 PCNA/RCHY1/UBA52/UBB/RPA1 5 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 11/1036 79/18670 0.004122 0.07492 0.06616 PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/PSMA3 11 GO:0009308 amine metabolic process 16/1036 138/18670 0.004153 0.07523 0.06643 ABAT/PSMA2/ODC1/KMO/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/TRH/KYNU/PSMB1/PSMD10/PSMC5/PSMA3 16 GO:1903829 positive regulation of cellular protein localization 30/1036 324/18670 0.004267 0.07689 0.0679 CD247/PARP1/IFNG/IL1B/CCT7/PRKCH/GZMB/FYN/TNF/CCT2/ZFAND1/CD2AP/CSNK2A2/YWHAQ/LRP1/EDEM1/NDC80/GPD1L/ICE1/LIF/PCM1/ANXA13/STK11/RIOK2/RANGRF/PMAIP1/ACSL3/MFF/AP2B1/PIK3R1 30 GO:0045930 negative regulation of mitotic cell cycle 31/1036 338/18670 0.004273 0.07689 0.0679 PCNA/NAE1/BTG3/BRD7/SKP1/DACT1/TOPBP1/PSMA2/PSMA5/PSMD14/BTG2/PSMA1/PSMC2/ZWINT/TNF/RBX1/PSMG2/PSME4/PSMD12/MSH2/NDC80/TNKS/TIMP2/PSMB1/FBXO5/PSMD10/CUL1/ATRX/DONSON/PSMC5/PSMA3 31 GO:0061900 glial cell activation 9/1036 58/18670 0.004411 0.07834 0.06918 IL6/IFNG/IL1B/CTSC/TNF/LRP1/TLR3/CST7/TLR6 9 GO:0032620 interleukin-17 production 7/1036 38/18670 0.004416 0.07834 0.06918 IL6/IFNG/PRKCQ/IL12B/IL23A/RFTN1/IL15 7 GO:0097064 ncRNA export from nucleus 7/1036 38/18670 0.004416 0.07834 0.06918 NUP107/NUP37/NUP205/NPM1/NUP85/NUP160/NUP214 7 GO:0002831 regulation of response to biotic stimulus 16/1036 139/18670 0.004458 0.07834 0.06918 OPTN/IL1B/C1QBP/IL12B/HTRA1/BIRC3/DDX60/ANKRD17/TRIM44/IL23A/PUM1/MAPK3/APOBEC3G/IL15/PQBP1/GPATCH3 16 GO:0015812 gamma-aminobutyric acid transport 4/1036 13/18670 0.004502 0.07834 0.06918 ABAT/NTSR1/SV2A/TRH 4 GO:0031650 regulation of heat generation 4/1036 13/18670 0.004502 0.07834 0.06918 ABAT/IL1B/TNF/NMU 4 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 4/1036 13/18670 0.004502 0.07834 0.06918 IL1B/IL12B/RASGRP1/IL23A 4 GO:0045086 positive regulation of interleukin-2 biosynthetic process 4/1036 13/18670 0.004502 0.07834 0.06918 IL1A/IL1B/PRKCQ/CD3E 4 GO:0090646 mitochondrial tRNA processing 4/1036 13/18670 0.004502 0.07834 0.06918 TRMT61B/CDK5RAP1/MTO1/TRMT5 4 GO:1902713 regulation of interferon-gamma secretion 4/1036 13/18670 0.004502 0.07834 0.06918 CD2/CD244/PTPN22/RASGRP1 4 GO:0006294 nucleotide-excision repair, preincision complex assembly 6/1036 29/18670 0.004548 0.07834 0.06918 PARP1/RBX1/GTF2H3/UBA52/UBB/RPA1 6 GO:0072606 interleukin-8 secretion 6/1036 29/18670 0.004548 0.07834 0.06918 CD2/CD244/PTPN22/ANXA1/TLR6/FCN1 6 GO:0071426 ribonucleoprotein complex export from nucleus 15/1036 127/18670 0.004553 0.07834 0.06918 NUP107/NUP37/EIF4A3/NUP205/NPM1/NUP85/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/NUP160/NUP214/RBM8A/UPF3B 15 GO:0044764 multi-organism cellular process 8/1036 48/18670 0.004559 0.07834 0.06918 C1QBP/BIRC3/DDX60/ANKRD17/CXCR4/PUM1/PGLYRP4/GPATCH3 8 GO:0034248 regulation of cellular amide metabolic process 41/1036 483/18670 0.00458 0.07845 0.06928 CCL5/IL6/IFNG/C1QBP/EIF4B/NCK1/PASK/PTCD3/METAP1/EIF4A3/FASTKD3/BTG2/ZFP36/USP16/TNF/CAPRIN2/NGRN/TIA1/MTIF2/PAIP1/DDX1/CDK5RAP1/HNRNPR/NPM1/UPF3A/ELAVL1/PUM1/RARA/MAPK3/PABPC1/SPHK2/ZNF706/CAPRIN1/EIF5/RPL22/RPS6KA3/CNBP/KHSRP/RBM8A/UPF3B/FXR1 41 GO:0042119 neutrophil activation 42/1036 498/18670 0.004641 0.07924 0.06997 FOLR3/NFKB1/CCL5/S100A11/DERA/LYZ/PTX3/ENPP4/ILF2/CTSC/PSMA2/CAT/CAPN1/CTSD/TOLLIP/PSMA5/PSMD14/P2RX1/DYNLL1/HP/PSMC2/TRPM2/CCT2/ARSA/ATP8A1/PSMD12/CPNE3/LILRB3/TIMP2/ELANE/PSMB1/AGPAT2/ALDH3B1/PRDX6/IL15/FCN1/VAT1/PGRMC1/APRT/CTSG/DOK3/BCR 42 GO:0051188 cofactor biosynthetic process 30/1036 326/18670 0.00466 0.07931 0.07003 PDSS1/PGK1/NUP107/IFNG/SUCLA2/NUP37/OPLAH/DLD/KMO/PDHX/GCLC/FYN/RSAD1/PPCS/NUP205/QDPR/NUP85/SLC22A13/KYNU/HDAC4/PFKP/SOD1/ACSL3/PDHB/NCOR1/NUP160/ACAT1/NUP214/COQ9/ZBTB7A 30 GO:0018205 peptidyl-lysine modification 35/1036 397/18670 0.00471 0.07991 0.07056 AUTS2/NUP107/BRD7/HAT1/CTR9/IL1B/FLCN/NUP37/SUPT7L/PLOD1/LIPT1/TOLLIP/YEATS2/NUP205/NCOA3/USPL1/PIAS4/NUP85/MAPK3/LIF/SPHK2/HDAC4/BRD1/HMG20A/ATAT1/SPI1/TAF5/CPA4/KANSL2/ATRX/TAF12/NUP160/NUP214/KAT8/ATG5 35 GO:0035690 cellular response to drug 33/1036 369/18670 0.004806 0.08127 0.07176 PCNA/MYC/NFKB1/IL6/IL1B/CHRM5/CD69/MTR/GCLC/FYN/PDE4B/TNF/PTPN22/TRPM2/CXCR4/ANXA1/FDX1/TLR3/QDPR/GLRA1/MAPK3/SPHK2/CHRM2/PDE8A/SPI1/DAXX/SETX/SOD1/ATRX/KCNQ1/ADAM15/SLAMF8/CBX8 33 GO:0070646 protein modification by small protein removal 28/1036 299/18670 0.004835 0.08151 0.07198 MYC/USP25/USP9Y/PSMA2/PSMA5/PSMD14/COPS4/PSMA1/PSMC2/SART3/USP16/BIRC3/SIAH2/USP1/PSME4/PSMD12/INO80B/USPL1/ASXL2/UBA52/PSMB1/USP18/JOSD1/PSMD10/TOMM20/UBB/PSMC5/PSMA3 28 GO:0071166 ribonucleoprotein complex localization 15/1036 128/18670 0.0049 0.08191 0.07233 NUP107/NUP37/EIF4A3/NUP205/NPM1/NUP85/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/NUP160/NUP214/RBM8A/UPF3B 15 GO:2000756 regulation of peptidyl-lysine acetylation 9/1036 59/18670 0.004955 0.08191 0.07233 AUTS2/BRD7/IL1B/FLCN/MAPK3/LIF/SPHK2/SPI1/ATG5 9 GO:2000736 regulation of stem cell differentiation 14/1036 116/18670 0.004959 0.08191 0.07233 LBH/PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/NUDT21/PSMB1/PSMD10/PSMC5/PSMA3 14 GO:0032204 regulation of telomere maintenance 11/1036 81/18670 0.005002 0.08191 0.07233 PARP1/MYC/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/ATRX/TERF1 11 GO:0006450 regulation of translational fidelity 5/1036 21/18670 0.005032 0.08191 0.07233 IARS2/YRDC/RPS5/CDK5RAP1/HSPA14 5 GO:0035590 purinergic nucleotide receptor signaling pathway 5/1036 21/18670 0.005032 0.08191 0.07233 GPR171/P2RX5/P2RX1/P2RX6/P2RY10 5 GO:0035743 CD4-positive, alpha-beta T cell cytokine production 5/1036 21/18670 0.005032 0.08191 0.07233 IL6/IL1B/IL12B/TBX21/RSAD2 5 GO:2000316 regulation of T-helper 17 type immune response 5/1036 21/18670 0.005032 0.08191 0.07233 MALT1/PRKCQ/IL12B/TBX21/IL23A 5 GO:0071222 cellular response to lipopolysaccharide 21/1036 205/18670 0.005033 0.08191 0.07233 CXCL11/NFKB1/CCL5/IL6/CTR9/IL1B/MALT1/KMO/IL12B/ZFP36/PDE4B/TNF/PTPN22/IL36A/XBP1/RARA/MAPK3/PRPF8/CTSG/BCR/LBP 21 GO:0033044 regulation of chromosome organization 31/1036 342/18670 0.005069 0.08191 0.07233 PARP1/MYC/AUTS2/BRD7/CTR9/IL1B/CCT7/SFPQ/FLCN/CDC23/PRKCQ/ANAPC5/SART3/PSMG2/CCT2/HIRA/ATR/NDC80/MAPK3/LIF/TNKS/SPHK2/HNRNPA2B1/RIOK2/FBXO5/SPI1/ZNHIT1/ATRX/RNF4/TERF1/ATG5 31 GO:0002709 regulation of T cell mediated immunity 10/1036 70/18670 0.005073 0.08191 0.07233 IL6/IL1B/MALT1/IL12B/WAS/CD1A/TBX21/IL23A/RSAD2/CLC 10 GO:0050766 positive regulation of phagocytosis 10/1036 70/18670 0.005073 0.08191 0.07233 IFNG/IL2RB/IL1B/PTX3/TNF/LRP1/IL15RA/IL15/SOD1/BCR 10 GO:0006611 protein export from nucleus 19/1036 179/18670 0.005073 0.08191 0.07233 NUP107/IL1B/NUP37/HSPA9/EIF4A3/NUP205/NPM1/NUP85/HNRNPA2B1/RIOK2/CSE1L/RBM15B/RRS1/CDC40/NUP160/NUP214/RBM8A/UPF3B/STRADA 19 GO:0030177 positive regulation of Wnt signaling pathway 19/1036 179/18670 0.005073 0.08191 0.07233 NFKB1/DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/RECK/CAPRIN2/PSME4/PSMD12/MLLT3/SULF1/TNKS/PSMB1/PSMD10/PSMC5/PSMA3 19 GO:0033683 nucleotide-excision repair, DNA incision 7/1036 39/18670 0.00513 0.08232 0.07269 PCNA/PARP1/RBX1/GTF2H3/UBA52/UBB/RPA1 7 GO:0042769 DNA damage response, detection of DNA damage 7/1036 39/18670 0.00513 0.08232 0.07269 PCNA/PARP1/RBX1/USP1/UBA52/UBB/RPA1 7 GO:0032757 positive regulation of interleukin-8 production 8/1036 49/18670 0.00519 0.08304 0.07332 CD2/IL1B/CD244/TNF/TLR3/ELANE/FCN1/LBP 8 GO:0046634 regulation of alpha-beta T cell activation 12/1036 93/18670 0.005252 0.08378 0.07398 IFNG/TGFBR2/MALT1/PRKCQ/IL12B/ANXA1/TBX21/IL23A/RARA/CD83/ZBTB16/CD3E 12 GO:0006090 pyruvate metabolic process 17/1036 154/18670 0.005272 0.08385 0.07404 PGK1/NUP107/IFNG/LDHB/NUP37/DLD/PDHX/NUP205/GLO1/NUP85/HDAC4/PFKP/PDHB/NCOR1/NUP160/NUP214/ZBTB7A 17 GO:0006109 regulation of carbohydrate metabolic process 21/1036 206/18670 0.00532 0.08436 0.0745 DYRK2/NFKB1/NUP107/IFNG/DUSP12/PASK/RORA/NUP37/CD244/NTSR1/CRY1/COX11/NUP205/CLK2/NUP85/HDAC4/PMAIP1/NCOR1/NUP160/NUP214/ZBTB7A 21 GO:0002708 positive regulation of lymphocyte mediated immunity 13/1036 105/18670 0.005358 0.08446 0.07458 IL6/SH2D1A/IL1B/MALT1/TNFSF13/IL12B/TNF/MSH2/CD1A/RASGRP1/TBX21/IL23A/RSAD2 13 GO:0002821 positive regulation of adaptive immune response 13/1036 105/18670 0.005358 0.08446 0.07458 IL6/IL1B/MALT1/TNFSF13/PRKCQ/IL12B/TNF/ANXA1/MSH2/CD1A/TBX21/IL23A/RSAD2 13 GO:0035066 positive regulation of histone acetylation 6/1036 30/18670 0.005423 0.08498 0.07504 AUTS2/BRD7/IL1B/MAPK3/LIF/SPHK2 6 GO:1902751 positive regulation of cell cycle G2/M phase transition 6/1036 30/18670 0.005423 0.08498 0.07504 CDC25B/SMARCD3/NPM1/DYRK3/FBXO5/CDC7 6 GO:0032637 interleukin-8 production 11/1036 82/18670 0.005495 0.08587 0.07582 CD2/IL1B/CD244/TNF/PTPN22/ANXA1/TLR3/ELANE/TLR6/FCN1/LBP 11 GO:0033260 nuclear DNA replication 9/1036 60/18670 0.005549 0.08621 0.07612 PCNA/ORC3/GMNN/ATRX/RPA1/TERF1/DONSON/CDC7/MCM6 9 GO:0046794 transport of virus 9/1036 60/18670 0.005549 0.08621 0.07612 NUP107/NUP37/NUP205/NUP85/UBA52/VPS37B/UBB/NUP160/NUP214 9 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 10/1036 71/18670 0.005618 0.08677 0.07662 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/IL15/IL3 10 GO:0044786 cell cycle DNA replication 10/1036 71/18670 0.005618 0.08677 0.07662 PCNA/ORC3/GMNN/FBXO5/ATRX/RPA1/TERF1/DONSON/CDC7/MCM6 10 GO:0051168 nuclear export 20/1036 194/18670 0.005686 0.08742 0.07719 NUP107/IL1B/MALT1/NUP37/HSPA9/EIF4A3/NUP205/NPM1/NUP85/HNRNPA2B1/RIOK2/CSE1L/RBM15B/RRS1/CDC40/NUP160/NUP214/RBM8A/UPF3B/STRADA 20 GO:0071453 cellular response to oxygen levels 23/1036 234/18670 0.005692 0.08742 0.07719 MYC/PGK1/RORA/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/RBX1/PSME4/PSMD12/PHB2/CHCHD2/DNM1L/UBA52/PSMB1/CITED2/PSMD10/UBB/PMAIP1/CA9/PSMC5/PSMA3 23 GO:1990266 neutrophil migration 14/1036 118/18670 0.005773 0.0884 0.07806 CXCL11/CCL5/IL1B/C1QBP/PDE4B/IL36A/DAPK2/IL23A/CD99/CCL11/CCL25/CCL23/SLAMF8/LBP 14 GO:0042180 cellular ketone metabolic process 24/1036 248/18670 0.005823 0.0884 0.07806 PDSS1/IL1B/OXCT1/PSMA2/INSIG1/ODC1/KMO/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/ANXA1/PSMD12/GLO1/AKR7A2/KYNU/PSMB1/AKR1B1/AKR1C3/PSMD10/PSMC5/COQ9/PSMA3 24 GO:0046434 organophosphate catabolic process 24/1036 248/18670 0.005823 0.0884 0.07806 HINT1/PGK1/NUP107/IFNG/DERA/NUP37/PNPLA6/NTSR1/PDE4B/NUP205/GPD1L/NUP85/HDAC4/PON1/PDE8A/PRDX6/PFKP/NUDT9/GDPD3/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 24 GO:1901991 negative regulation of mitotic cell cycle phase transition 24/1036 248/18670 0.005823 0.0884 0.07806 PCNA/NAE1/BRD7/SKP1/DACT1/TOPBP1/PSMA2/PSMA5/PSMD14/BTG2/PSMA1/PSMC2/RBX1/PSMG2/PSME4/PSMD12/NDC80/PSMB1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/PSMA3 24 GO:1903793 positive regulation of anion transport 8/1036 50/18670 0.005885 0.08909 0.07867 ABAT/ABCB1/IL1B/KMO/NTSR1/ATP8A1/TRH/CYP4A11 8 GO:0002369 T cell cytokine production 7/1036 40/18670 0.005926 0.08946 0.079 IL6/IL1B/MALT1/IL12B/TBX21/RSAD2/CLC 7 GO:0007411 axon guidance 26/1036 276/18670 0.005988 0.09014 0.07959 SOS1/RANBP9/PRKCQ/FYN/CXCR4/LHX3/BMPR1B/PLXNB2/ARTN/LRP1/SEMA4G/CYFIP2/BCL11B/PIK3CA/MAPK3/SEMA3G/PDLIM7/DOK1/DSCAM/NTN1/B3GNT2/PIK3R1/EFNB3/CRMP1/GFRA4/FEZ1 26 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4/1036 14/18670 0.006028 0.09024 0.07968 ZNHIT3/ZNHIT6/RPL35/WDR12 4 GO:0090069 regulation of ribosome biogenesis 4/1036 14/18670 0.006028 0.09024 0.07968 TRMT112/RIOK2/DIMT1/SHQ1 4 GO:0006338 chromatin remodeling 19/1036 182/18670 0.006059 0.09024 0.07968 MYC/ITGB3BP/ACTR6/RBBP4/PSME4/INO80B/SMARCD3/NPM1/HDAC4/KDM5C/RBBP7/KDM5D/DAXX/BPTF/ZNHIT1/ATRX/SATB1/SMARCA5/ZBTB7A 19 GO:0034113 heterotypic cell-cell adhesion 9/1036 61/18670 0.006197 0.09024 0.07968 CD2/IL1B/MADCAM1/ITGA4/ITGA7/TNF/LCK/PARVA/MBP 9 GO:0009301 snRNA transcription 10/1036 72/18670 0.006208 0.09024 0.07968 POU2F2/INTS12/GTF2A2/INTS8/USPL1/ICE1/TBP/ICE2/TAF5/GTF2E1 10 GO:0032392 DNA geometric change 14/1036 119/18670 0.006219 0.09024 0.07968 PARP1/ASCC3/RBX1/GTF2H3/ANXA1/DDX1/UBA52/HNRNPA2B1/UBB/SETX/ATRX/RPA1/MCM6/POLQ 14 GO:0000717 nucleotide-excision repair, DNA duplex unwinding 5/1036 22/18670 0.006219 0.09024 0.07968 PARP1/RBX1/GTF2H3/UBA52/UBB 5 GO:0006085 acetyl-CoA biosynthetic process 5/1036 22/18670 0.006219 0.09024 0.07968 DLD/PDHX/PPCS/PDHB/ACAT1 5 GO:0008053 mitochondrial fusion 5/1036 22/18670 0.006219 0.09024 0.07968 MFN1/DNM1L/CHCHD3/VAT1/MFF 5 GO:0032069 regulation of nuclease activity 5/1036 22/18670 0.006219 0.09024 0.07968 PCNA/TCEA1/GZMA/NPM1/TERF1 5 GO:0042094 interleukin-2 biosynthetic process 5/1036 22/18670 0.006219 0.09024 0.07968 IL1A/IL1B/PRKCQ/ZFP36/CD3E 5 GO:0042359 vitamin D metabolic process 5/1036 22/18670 0.006219 0.09024 0.07968 NFKB1/IFNG/IL1B/TNF/PIAS4 5 GO:0045624 positive regulation of T-helper cell differentiation 5/1036 22/18670 0.006219 0.09024 0.07968 MALT1/IL12B/ANXA1/IL23A/RARA 5 GO:0002702 positive regulation of production of molecular mediator of immune response 12/1036 95/18670 0.006231 0.09024 0.07968 IL6/IL1B/MALT1/TNFSF13/CD244/DDX1/MSH2/DDX21/TBX21/XBP1/RSAD2/MAPK3 12 GO:0097485 neuron projection guidance 26/1036 277/18670 0.006271 0.09057 0.07998 SOS1/RANBP9/PRKCQ/FYN/CXCR4/LHX3/BMPR1B/PLXNB2/ARTN/LRP1/SEMA4G/CYFIP2/BCL11B/PIK3CA/MAPK3/SEMA3G/PDLIM7/DOK1/DSCAM/NTN1/B3GNT2/PIK3R1/EFNB3/CRMP1/GFRA4/FEZ1 26 GO:0002724 regulation of T cell cytokine production 6/1036 31/18670 0.006414 0.09239 0.08159 IL6/IL1B/MALT1/TBX21/RSAD2/CLC 6 GO:0097529 myeloid leukocyte migration 21/1036 210/18670 0.006608 0.09493 0.08383 CXCL11/CCL5/IL6/IL1B/C1QBP/CHGA/PDE4B/IL36A/DAPK2/ANXA1/IL23A/NUP85/MAPK3/CD99/CCL11/PTGER4/CD9/CCL25/CCL23/SLAMF8/LBP 21 GO:0032206 positive regulation of telomere maintenance 8/1036 51/18670 0.006648 0.09525 0.08411 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/ATRX 8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 12/1036 96/18670 0.006772 0.09676 0.08544 PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/PSMD12/PSMB1/PSMD10/PSMC5/SEC24A/PSMA3 12 GO:0043467 regulation of generation of precursor metabolites and energy 17/1036 158/18670 0.006798 0.09688 0.08555 DYRK2/PGK1/NUP107/IFNG/FLCN/PASK/NUP37/NUP205/PHB2/PIK3CA/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 17 GO:1904356 regulation of telomere maintenance via telomere lengthening 9/1036 62/18670 0.006901 0.09809 0.08662 PARP1/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/TERF1 9 GO:0034404 nucleobase-containing small molecule biosynthetic process 22/1036 226/18670 0.007531 0.1065 0.09402 HINT1/PGK1/NUP107/IFNG/DCK/DERA/CMPK1/NUP37/PDE4B/NUP205/UCKL1/NUP85/HDAC4/PDE8A/PFKP/NUDT9/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 22 GO:0032814 regulation of natural killer cell activation 6/1036 32/18670 0.007531 0.1065 0.09402 IL12B/PTPN22/RASGRP1/IL23A/IL15/PGLYRP4 6 GO:0000715 nucleotide-excision repair, DNA damage recognition 5/1036 23/18670 0.007589 0.1067 0.09425 PARP1/COPS4/RBX1/UBA52/UBB 5 GO:0051043 regulation of membrane protein ectodomain proteolysis 5/1036 23/18670 0.007589 0.1067 0.09425 IFNG/IL1B/TNF/TIMP2/TIMP4 5 GO:0046686 response to cadmium ion 9/1036 63/18670 0.007666 0.1075 0.09494 PCNA/CAT/NPC1/GCLC/MAPK3/AKR1C3/DAXX/CYB5A/SOD1 9 GO:1905477 positive regulation of protein localization to membrane 14/1036 122/18670 0.007722 0.108 0.09539 IFNG/PRKCH/GZMB/FYN/TNF/YWHAQ/LRP1/ANXA13/RANGRF/PMAIP1/ACSL3/MFF/AP2B1/PIK3R1 14 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production 4/1036 15/18670 0.007864 0.1094 0.0966 IL1B/IL12B/RASGRP1/IL23A 4 GO:0042362 fat-soluble vitamin biosynthetic process 4/1036 15/18670 0.007864 0.1094 0.0966 NFKB1/IFNG/IL1B/TNF 4 GO:0002446 neutrophil mediated immunity 41/1036 499/18670 0.007891 0.1094 0.0966 FOLR3/NFKB1/IL6/S100A11/DERA/LYZ/PTX3/ENPP4/ILF2/CTSC/PSMA2/CAT/CAPN1/CTSD/TOLLIP/PSMA5/PSMD14/P2RX1/DYNLL1/HP/PSMC2/TRPM2/CCT2/ARSA/ATP8A1/PSMD12/CPNE3/LILRB3/TIMP2/ELANE/PSMB1/AGPAT2/ALDH3B1/PRDX6/FCN1/VAT1/PGRMC1/APRT/CTSG/DOK3/BCR 41 GO:0032508 DNA duplex unwinding 13/1036 110/18670 0.007901 0.1094 0.0966 PARP1/ASCC3/RBX1/GTF2H3/ANXA1/DDX1/UBA52/UBB/SETX/ATRX/RPA1/MCM6/POLQ 13 GO:0006405 RNA export from nucleus 15/1036 135/18670 0.007976 0.1101 0.09726 NUP107/NUP37/EIF4A3/NUP205/NPM1/NUP85/HNRNPA2B1/RIOK2/RBM15B/RRS1/CDC40/NUP160/NUP214/RBM8A/UPF3B 15 GO:0043312 neutrophil degranulation 40/1036 485/18670 0.00811 0.1117 0.09864 FOLR3/NFKB1/S100A11/DERA/LYZ/PTX3/ENPP4/ILF2/CTSC/PSMA2/CAT/CAPN1/CTSD/TOLLIP/PSMA5/PSMD14/P2RX1/DYNLL1/HP/PSMC2/TRPM2/CCT2/ARSA/ATP8A1/PSMD12/CPNE3/LILRB3/TIMP2/ELANE/PSMB1/AGPAT2/ALDH3B1/PRDX6/FCN1/VAT1/PGRMC1/APRT/CTSG/DOK3/BCR 40 GO:2001252 positive regulation of chromosome organization 18/1036 174/18670 0.008134 0.1117 0.09867 AUTS2/BRD7/CTR9/IL1B/CCT7/SFPQ/PRKCQ/ANAPC5/SART3/CCT2/ATR/MAPK3/LIF/TNKS/SPHK2/HNRNPA2B1/ATRX/TERF1 18 GO:0007249 I-kappaB kinase/NF-kappaB signaling 25/1036 269/18670 0.008193 0.1122 0.09909 RHOH/OPTN/IL1B/APOL3/MALT1/RORA/SNIP1/FYN/BIRC3/TNF/TRAF5/ANKRD17/IL36A/DDX1/DDX21/TLR3/UBA52/SPHK2/ALPK1/TLR6/UBB/ROR1/ZMYND11/SLC20A1/EDA2R 25 GO:0016579 protein deubiquitination 26/1036 283/18670 0.00821 0.1122 0.09909 MYC/USP25/USP9Y/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/SART3/USP16/BIRC3/SIAH2/USP1/PSME4/PSMD12/INO80B/ASXL2/UBA52/PSMB1/USP18/JOSD1/PSMD10/TOMM20/UBB/PSMC5/PSMA3 26 GO:0006353 DNA-templated transcription, termination 10/1036 75/18670 0.008271 0.1126 0.09945 POLR1B/PCF11/GTF2H3/POLR3K/NUDT21/CSTF2T/TBP/SNRPF/SETX/TAF1C 10 GO:0071621 granulocyte chemotaxis 14/1036 123/18670 0.008282 0.1126 0.09945 CXCL11/CCL5/IL1B/C1QBP/PDE4B/IL36A/DAPK2/ANXA1/IL23A/MAPK3/CCL11/CCL25/CCL23/LBP 14 GO:0000387 spliceosomal snRNP assembly 8/1036 53/18670 0.008397 0.1139 0.1006 SRSF10/SNRPD1/SART3/CLNS1A/COIL/PRPF8/SNRPF/SNRPD2 8 GO:0010257 NADH dehydrogenase complex assembly 9/1036 64/18670 0.008493 0.1141 0.1008 TMEM126B/NDUFV1/NDUFV2/NDUFA10/NDUFA6/NDUFB4/OXA1L/NDUFS1/NDUFS4 9 GO:0032981 mitochondrial respiratory chain complex I assembly 9/1036 64/18670 0.008493 0.1141 0.1008 TMEM126B/NDUFV1/NDUFV2/NDUFA10/NDUFA6/NDUFB4/OXA1L/NDUFS1/NDUFS4 9 GO:0045670 regulation of osteoclast differentiation 9/1036 64/18670 0.008493 0.1141 0.1008 IFNG/GNAS/IL12B/TNF/TLR3/IL23A/LILRB3/LILRB4/PIK3R1 9 GO:0009142 nucleoside triphosphate biosynthetic process 19/1036 188/18670 0.008499 0.1141 0.1008 PARP1/PGK1/NUP107/IFNG/FLCN/CMPK1/NUP37/NUP205/UCKL1/CYC1/NUP85/SPHK2/HDAC4/SUCLG1/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 19 GO:0046165 alcohol biosynthetic process 18/1036 175/18670 0.008612 0.1153 0.1019 NFKB1/IFNG/IL1B/IDI1/MSMO1/INSIG1/CD244/NTSR1/PLCL1/TNF/NFYB/QDPR/PLCB3/SPHK2/AKR1B1/SC5D/SOD1/CNBP 18 GO:0002706 regulation of lymphocyte mediated immunity 16/1036 149/18670 0.00864 0.1154 0.1019 CD96/IL6/SH2D1A/IL1B/MALT1/TNFSF13/IL12B/TNF/WAS/MSH2/CD1A/RASGRP1/TBX21/IL23A/RSAD2/CLC 16 GO:2000758 positive regulation of peptidyl-lysine acetylation 6/1036 33/18670 0.008782 0.1165 0.1029 AUTS2/BRD7/IL1B/MAPK3/LIF/SPHK2 6 GO:0071103 DNA conformation change 29/1036 327/18670 0.008783 0.1165 0.1029 PARP1/ITGB3BP/HAT1/RBBP4/ASCC3/SART3/RBX1/HIRA/GATAD1/PSME4/GTF2H3/ANXA1/DDX1/NAP1L1/NPM1/TSPY1/UBA52/HNRNPA2B1/RBBP7/DAXX/UBB/SETX/ATRX/RPA1/MCM6/NCAPG2/SMARCA5/SMC2/POLQ 29 GO:0006612 protein targeting to membrane 20/1036 202/18670 0.008788 0.1165 0.1029 ZDHHC4/FYN/RPL6/SRP72/RPS7/RPS5/RPL35/RPS4Y1/TRAM1/RPL35A/UBA52/RPL19/RPL29/VPS37B/RPL15/RPS21/RPL11/MFF/RPL22/RPL36 20 GO:0072522 purine-containing compound biosynthetic process 28/1036 313/18670 0.008865 0.1171 0.1034 PARP1/PGK1/NUP107/IFNG/PRPS2/DCK/FLCN/NUP37/DLD/PDHX/PRPS1/PPCS/NUP205/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/PRPSAP2/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 28 GO:0060612 adipose tissue development 7/1036 43/18670 0.008871 0.1171 0.1034 ARID5B/OXCT1/XBP1/PIK3CA/UBB/ZNF516/ACAT1 7 GO:0002283 neutrophil activation involved in immune response 40/1036 488/18670 0.008946 0.1177 0.104 FOLR3/NFKB1/S100A11/DERA/LYZ/PTX3/ENPP4/ILF2/CTSC/PSMA2/CAT/CAPN1/CTSD/TOLLIP/PSMA5/PSMD14/P2RX1/DYNLL1/HP/PSMC2/TRPM2/CCT2/ARSA/ATP8A1/PSMD12/CPNE3/LILRB3/TIMP2/ELANE/PSMB1/AGPAT2/ALDH3B1/PRDX6/FCN1/VAT1/PGRMC1/APRT/CTSG/DOK3/BCR 40 GO:0009408 response to heat 18/1036 176/18670 0.009112 0.1196 0.1056 IL1A/NUP107/NUP37/HSPA9/ATP2A2/GCLC/NUP205/DNAJB1/ATR/NUP85/MAPK3/HSPA14/RBBP7/DAXX/SOD1/RPA1/NUP160/NUP214 18 GO:0009451 RNA modification 17/1036 163/18670 0.009189 0.1204 0.1063 TFB2M/FBL/SEPHS1/EMG1/TARBP1/TRMT61B/CDK5RAP1/THUMPD1/MTO1/RBM15/TRMT5/TRMT112/TPRKB/APOBEC3G/RBM15B/DIMT1/CBLL1 17 GO:0006164 purine nucleotide biosynthetic process 27/1036 300/18670 0.009306 0.1216 0.1074 PARP1/PGK1/NUP107/IFNG/PRPS2/FLCN/NUP37/DLD/PDHX/PRPS1/PPCS/NUP205/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/PRPSAP2/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 27 GO:0002440 production of molecular mediator of immune response 26/1036 286/18670 0.009351 0.1216 0.1074 TRDV3/CD96/ITM2A/IL6/IL1B/POU2F2/MALT1/TNFSF13/IL12B/HLA-DQB1/CD244/CHGA/TNF/DDX1/MSH2/DDX21/TBX21/TLR3/XBP1/RSAD2/MAPK3/SPHK2/ELANE/CLC/ATG5/POLQ 26 GO:0051403 stress-activated MAPK cascade 26/1036 286/18670 0.009351 0.1216 0.1074 AIDA/SLAMF1/MYC/NFKB1/IL1B/SKP1/DACT1/ZFP36/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP4K5/MAPK3/UBA52/PTGER4/MAP4K2/TLR6/IGBP1/CUL1/DAXX/UBB/ZMYND11/NCOR1/EDA2R 26 GO:0006336 DNA replication-independent nucleosome assembly 8/1036 54/18670 0.00939 0.1218 0.1076 ITGB3BP/HAT1/RBBP4/HIRA/NPM1/RBBP7/ATRX/SMARCA5 8 GO:0009063 cellular amino acid catabolic process 14/1036 125/18670 0.0095 0.1229 0.1085 ABAT/ADO/DLD/ENOSF1/KMO/QDPR/AHCY/BCKDHA/MCCC1/KYNU/OTC/CBS/GAD2/ACAT1 14 GO:0030099 myeloid cell differentiation 35/1036 416/18670 0.009524 0.1229 0.1086 PARP1/MYC/IFNG/TGFBR2/GPR171/CTR9/PRKCQ/GNAS/HSPA9/IL12B/ZFP36/TNF/CLEC1B/TGFBR3/GLO1/PRKX/TLR3/IL23A/RARA/LILRB3/ACTN1/LIF/RBM15/DYRK3/GPR183/ZBTB16/SPI1/IL15/HAX1/RHAG/LILRB4/PIK3R1/KAT8/NCAPG2/ZBTB7A 35 GO:0006473 protein acetylation 20/1036 204/18670 0.009746 0.1255 0.1108 AUTS2/BRD7/HAT1/IL1B/FLCN/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/ATAT1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 20 GO:0001977 renal system process involved in regulation of blood volume 4/1036 16/18670 0.01003 0.1268 0.112 HSD11B2/EMP2/CYP4A11/CYP4F12 4 GO:0002295 T-helper cell lineage commitment 4/1036 16/18670 0.01003 0.1268 0.112 IL6/IL12B/TBX21/IL23A 4 GO:0032604 granulocyte macrophage colony-stimulating factor production 4/1036 16/18670 0.01003 0.1268 0.112 IL1B/IL12B/RASGRP1/IL23A 4 GO:0055119 relaxation of cardiac muscle 4/1036 16/18670 0.01003 0.1268 0.112 ATP2A2/CHGA/PDE4B/ATP1B1 4 GO:0070897 transcription preinitiation complex assembly 7/1036 44/18670 0.01006 0.1268 0.112 GTF3C3/GTF2A2/PSMC2/TBP/TAF1C/TAF12/PSMC5 7 GO:0046394 carboxylic acid biosynthetic process 38/1036 462/18670 0.0101 0.1268 0.112 ABAT/NFKB1/ABCD3/PGK1/NUP107/IFNG/SLC35D1/IL1B/SUCLA2/NUP37/SEPHS1/CHST12/INSIG1/PLOD1/KMO/MTR/UGP2/NUP205/ANXA1/XBP1/NUP85/SCP2/KYNU/HDAC4/OTC/CH25H/CYP2C9/CBS/AKR1C3/PFKP/ASNSD1/AASDHPPT/ACSL3/NCOR1/NUP160/NUP214/SLC1A3/ZBTB7A 38 GO:0046427 positive regulation of JAK-STAT cascade 11/1036 89/18670 0.0101 0.1268 0.112 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 11 GO:0006409 tRNA export from nucleus 6/1036 34/18670 0.01018 0.1268 0.112 NUP107/NUP37/NUP205/NUP85/NUP160/NUP214 6 GO:0032212 positive regulation of telomere maintenance via telomerase 6/1036 34/18670 0.01018 0.1268 0.112 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS 6 GO:0032660 regulation of interleukin-17 production 6/1036 34/18670 0.01018 0.1268 0.112 IL6/IFNG/PRKCQ/IL12B/IL23A/IL15 6 GO:0032892 positive regulation of organic acid transport 6/1036 34/18670 0.01018 0.1268 0.112 ABAT/IL1B/KMO/NTSR1/TRH/CYP4A11 6 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 6/1036 34/18670 0.01018 0.1268 0.112 EEF1E1/ATR/DYRK3/PSMD10/DYRK1A/PMAIP1 6 GO:0071431 tRNA-containing ribonucleoprotein complex export from nucleus 6/1036 34/18670 0.01018 0.1268 0.112 NUP107/NUP37/NUP205/NUP85/NUP160/NUP214 6 GO:0002793 positive regulation of peptide secretion 26/1036 288/18670 0.01018 0.1268 0.112 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/OXCT1/DYNLL1/CD244/TNF/PTPN22/CD2AP/LRP1/RASGRP1/DNM1L/XBP1/MBP/TRH/MAPK3/AIMP1/PTGER4/GHRHR/FCN1/NMU/SEC24A 26 GO:0051222 positive regulation of protein transport 35/1036 418/18670 0.01021 0.1269 0.112 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/OXCT1/DYNLL1/CD244/FYN/TNF/PTPN22/ZFAND1/CD2AP/CSNK2A2/LRP1/RASGRP1/DNM1L/XBP1/EDEM1/MBP/TRH/ICE1/MAPK3/PCM1/ANXA13/RIOK2/PTGER4/FCN1/ACSL3/MFF/NMU/PIK3R1/SEC24A 35 GO:0008202 steroid metabolic process 29/1036 331/18670 0.01029 0.1276 0.1127 NFKB1/IFNG/IL1B/IDI1/MSMO1/CETP/LIPA/RORA/CAT/HSD11B2/INSIG1/LDLRAP1/NPC1/TNF/FDX1/LIPE/NFYB/PIAS4/SCP2/PON1/CH25H/CYP2C9/AKR1B1/AKR1C3/RDH16/SC5D/SOD1/CNBP/ACAT1 29 GO:0016053 organic acid biosynthetic process 38/1036 463/18670 0.01043 0.1291 0.114 ABAT/NFKB1/ABCD3/PGK1/NUP107/IFNG/SLC35D1/IL1B/SUCLA2/NUP37/SEPHS1/CHST12/INSIG1/PLOD1/KMO/MTR/UGP2/NUP205/ANXA1/XBP1/NUP85/SCP2/KYNU/HDAC4/OTC/CH25H/CYP2C9/CBS/AKR1C3/PFKP/ASNSD1/AASDHPPT/ACSL3/NCOR1/NUP160/NUP214/SLC1A3/ZBTB7A 38 GO:0034724 DNA replication-independent nucleosome organization 8/1036 55/18670 0.01047 0.1292 0.1141 ITGB3BP/HAT1/RBBP4/HIRA/NPM1/RBBP7/ATRX/SMARCA5 8 GO:0009108 coenzyme biosynthetic process 24/1036 261/18670 0.01068 0.1316 0.1162 PDSS1/PGK1/NUP107/IFNG/NUP37/DLD/KMO/PDHX/PPCS/NUP205/QDPR/NUP85/SLC22A13/KYNU/HDAC4/PFKP/ACSL3/PDHB/NCOR1/NUP160/ACAT1/NUP214/COQ9/ZBTB7A 24 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 10/1036 78/18670 0.01082 0.133 0.1174 LBH/PARP1/TRIM68/CRY1/RWDD1/PHB2/GHRHR/KDM5D/NCOR1/ZBTB7A 10 GO:0045672 positive regulation of osteoclast differentiation 5/1036 25/18670 0.01093 0.1334 0.1178 IFNG/GNAS/IL12B/TNF/IL23A 5 GO:0050901 leukocyte tethering or rolling 5/1036 25/18670 0.01093 0.1334 0.1178 MADCAM1/ITGA4/TNF/ELANE/CCL25 5 GO:0072677 eosinophil migration 5/1036 25/18670 0.01093 0.1334 0.1178 CCL5/DAPK2/CCL11/PTGER4/CCL23 5 GO:0071356 cellular response to tumor necrosis factor 26/1036 291/18670 0.01154 0.1404 0.124 NFKB1/CCL5/RORA/PSMA2/TNFSF13/PSMA5/PSMD14/PSMA1/ZFP36/PSMC2/BIRC3/TNF/PSME4/PSMD12/PIAS4/MAPK3/PRPF8/HDAC4/PSMB1/CCL11/PSMD10/CCL25/CCL23/PSMC5/EDA2R/PSMA3 26 GO:1903078 positive regulation of protein localization to plasma membrane 8/1036 56/18670 0.01164 0.1413 0.1248 IFNG/PRKCH/TNF/LRP1/ANXA13/RANGRF/ACSL3/PIK3R1 8 GO:0045622 regulation of T-helper cell differentiation 6/1036 35/18670 0.01172 0.142 0.1254 MALT1/IL12B/ANXA1/TBX21/IL23A/RARA 6 GO:0006110 regulation of glycolytic process 10/1036 79/18670 0.01179 0.142 0.1254 NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 10 GO:1900034 regulation of cellular response to heat 10/1036 79/18670 0.01179 0.142 0.1254 NUP107/NUP37/NUP205/DNAJB1/ATR/NUP85/MAPK3/RPA1/NUP160/NUP214 10 GO:1903312 negative regulation of mRNA metabolic process 10/1036 79/18670 0.01179 0.142 0.1254 CTR9/C1QBP/SRSF10/HNRNPA0/ZFP36/PAIP1/ELAVL1/PABPC1/HNRNPA2B1/DYRK1A 10 GO:0071216 cellular response to biotic stimulus 22/1036 236/18670 0.01216 0.1461 0.129 CXCL11/NFKB1/CCL5/IL6/CTR9/IL1B/MALT1/KMO/IL12B/ZFP36/PDE4B/TNF/PTPN22/IL36A/XBP1/RARA/MAPK3/PRPF8/TLR6/CTSG/BCR/LBP 22 GO:0001906 cell killing 17/1036 168/18670 0.01221 0.1463 0.1292 SH2D1A/IFNG/LYZ/CTSC/HMGN2/IL12B/PRF1/GZMB/CHGA/CD1A/RASGRP1/EMP2/IL23A/ELANE/CD5L/CTSG/PGLYRP4 17 GO:1903707 negative regulation of hemopoiesis 16/1036 155/18670 0.01237 0.1474 0.1302 MYC/GPR171/CTR9/HSPA9/ZFP36/ANXA1/TBX21/TLR3/RARA/LILRB3/RBM15/ZBTB16/LILRB4/PIK3R1/PGLYRP4/NCAPG2 16 GO:1900542 regulation of purine nucleotide metabolic process 15/1036 142/18670 0.01243 0.1474 0.1302 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/DNM1L/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0031343 positive regulation of cell killing 9/1036 68/18670 0.01249 0.1474 0.1302 SH2D1A/IFNG/IL12B/PRF1/CD1A/RASGRP1/IL23A/CD5L/PGLYRP4 9 GO:0009260 ribonucleotide biosynthetic process 26/1036 293/18670 0.01252 0.1474 0.1302 PARP1/PGK1/NUP107/IFNG/FLCN/CMPK1/NUP37/DLD/PDHX/PPCS/NUP205/UCKL1/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 26 GO:0030593 neutrophil chemotaxis 12/1036 104/18670 0.01254 0.1474 0.1302 CXCL11/CCL5/IL1B/C1QBP/PDE4B/IL36A/DAPK2/IL23A/CCL11/CCL25/CCL23/LBP 12 GO:0000963 mitochondrial RNA processing 4/1036 17/18670 0.01255 0.1474 0.1302 TRMT61B/CDK5RAP1/MTO1/TRMT5 4 GO:0010224 response to UV-B 4/1036 17/18670 0.01255 0.1474 0.1302 IL12B/MSH2/HMGN1/STK11 4 GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 4/1036 17/18670 0.01255 0.1474 0.1302 IL6/IL12B/TBX21/IL23A 4 GO:0070131 positive regulation of mitochondrial translation 4/1036 17/18670 0.01255 0.1474 0.1302 C1QBP/FASTKD3/NGRN/CDK5RAP1 4 GO:0009166 nucleotide catabolic process 18/1036 182/18670 0.01262 0.1479 0.1306 HINT1/PGK1/NUP107/IFNG/DERA/NUP37/PDE4B/NUP205/NUP85/HDAC4/PDE8A/PFKP/NUDT9/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 18 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 22/1036 237/18670 0.01273 0.1486 0.1312 RHOH/OPTN/IL1B/APOL3/MALT1/RORA/FYN/BIRC3/TNF/TRAF5/ANKRD17/IL36A/DDX1/DDX21/TLR3/SPHK2/ALPK1/TLR6/ROR1/ZMYND11/SLC20A1/EDA2R 22 GO:0002437 inflammatory response to antigenic stimulus 7/1036 46/18670 0.01277 0.1486 0.1312 IL12B/PNMA1/PSMA1/TNF/RASGRP1/AHCY/ELANE 7 GO:0035196 production of miRNAs involved in gene silencing by miRNA 7/1036 46/18670 0.01277 0.1486 0.1312 DROSHA/SNIP1/PPP1R8/PRKRA/PUM1/HNRNPA2B1/NCOR1 7 GO:1904894 positive regulation of STAT cascade 11/1036 92/18670 0.01281 0.1486 0.1312 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 11 GO:0022617 extracellular matrix disassembly 10/1036 80/18670 0.01283 0.1486 0.1312 IL6/CAPN1/HTRA1/LRP1/TIMP2/ELANE/TPSAB1/CLASP1/ADAM15/CTSG 10 GO:0002685 regulation of leukocyte migration 19/1036 196/18670 0.01292 0.1486 0.1312 CCL5/IL6/C1QBP/GPR18/MADCAM1/ITGA4/TNF/DAPK2/ANXA1/IL23A/MAPK3/ELANE/CD99/PTGER4/CD9/CCL25/SLAMF8/BCR/LBP 19 GO:0002230 positive regulation of defense response to virus by host 5/1036 26/18670 0.01293 0.1486 0.1312 IL12B/TRIM44/IL23A/APOBEC3G/PQBP1 5 GO:0070911 global genome nucleotide-excision repair 5/1036 26/18670 0.01293 0.1486 0.1312 PARP1/RBX1/GTF2H3/UBA52/UBB 5 GO:0002761 regulation of myeloid leukocyte differentiation 13/1036 117/18670 0.01296 0.1486 0.1312 MYC/IFNG/GNAS/IL12B/TNF/TLR3/IL23A/RARA/LILRB3/LIF/HAX1/LILRB4/PIK3R1 13 GO:1900371 regulation of purine nucleotide biosynthetic process 13/1036 117/18670 0.01296 0.1486 0.1312 PARP1/NUP107/IFNG/FLCN/NUP37/NUP205/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0051249 regulation of lymphocyte activation 39/1036 485/18670 0.01305 0.1493 0.1319 CD38/DROSHA/SOS1/CCL5/IL6/IFNG/TGFBR2/CD2/IL1B/MALT1/NCK1/TNFSF13/PRKCQ/IL12B/ICOS/FYN/PTPN22/ANXA1/MSH2/RASGRP1/TBX21/LCK/XBP1/IL23A/RARA/PIK3CA/CD83/GPR183/ZBTB16/IL15/SOD1/CD3E/LILRB4/SLAMF8/PIK3R1/PGLYRP4/TRBC1/EFNB3/CLC 39 GO:0009127 purine nucleoside monophosphate biosynthetic process 18/1036 183/18670 0.0133 0.1515 0.1338 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/APRT/NCOR1/NUP160/NUP214/ZBTB7A 18 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 18/1036 183/18670 0.0133 0.1515 0.1338 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/APRT/NCOR1/NUP160/NUP214/ZBTB7A 18 GO:0051973 positive regulation of telomerase activity 6/1036 36/18670 0.01342 0.1522 0.1344 MYC/PRKCQ/CCT2/MAPK3/TNKS/HNRNPA2B1 6 GO:1902622 regulation of neutrophil migration 6/1036 36/18670 0.01342 0.1522 0.1344 C1QBP/DAPK2/IL23A/CD99/SLAMF8/LBP 6 GO:0055074 calcium ion homeostasis 38/1036 471/18670 0.01347 0.1525 0.1346 CD38/CXCL11/CCL5/CCR3/P2RX5/GPR18/CLIC2/ATP2A2/CXCR6/P2RX1/FYN/NTSR1/FAM155B/TRPM2/SV2A/CXCR4/LRP1/LCK/CALB2/SLC8A2/PLCB3/CCKBR/ATP1B1/ELANE/JPH3/AVPR1B/CCL11/PTGER4/ATP2B2/LPAR6/MCOLN1/NMU/TRIM24/TRPM1/CCL23/P2RY10/GRIN2D/ATG5 38 GO:0031503 protein-containing complex localization 25/1036 281/18670 0.01372 0.155 0.1369 NUP107/SFPQ/NUP37/IFT22/EIF4A3/DYNLL1/HSPB11/NUP205/KIFAP3/ATR/NPM1/NUP85/HNRNPA2B1/PCM1/RIOK2/DBN1/RBM15B/RRS1/CDC40/AP2B1/NUP160/TERF1/NUP214/RBM8A/UPF3B 25 GO:1901988 negative regulation of cell cycle phase transition 24/1036 267/18670 0.01384 0.1558 0.1375 PCNA/NAE1/BRD7/SKP1/DACT1/TOPBP1/PSMA2/PSMA5/PSMD14/BTG2/PSMA1/PSMC2/RBX1/PSMG2/PSME4/PSMD12/NDC80/PSMB1/FBXO5/PSMD10/CUL1/DONSON/PSMC5/PSMA3 24 GO:0030808 regulation of nucleotide biosynthetic process 13/1036 118/18670 0.01385 0.1558 0.1375 PARP1/NUP107/IFNG/FLCN/NUP37/NUP205/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0000209 protein polyubiquitination 27/1036 310/18670 0.01391 0.1558 0.1375 SKP1/FBXO21/CDC23/PSMA2/ANAPC5/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/PTPN22/RBX1/TRIM44/PSME4/FBXW12/HERC6/PSMD12/UBA52/TNKS/PSMB1/PSMD10/CUL1/UBB/RNF115/RNF4/PSMC5/PSMA3 27 GO:0030811 regulation of nucleotide catabolic process 10/1036 81/18670 0.01393 0.1558 0.1375 NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 10 GO:1902930 regulation of alcohol biosynthetic process 10/1036 81/18670 0.01393 0.1558 0.1375 NFKB1/IFNG/IL1B/IDI1/CD244/NTSR1/TNF/NFYB/SC5D/SOD1 10 GO:0043409 negative regulation of MAPK cascade 18/1036 184/18670 0.014 0.1562 0.1379 AIDA/MYC/RANBP9/DUSP2/IL1B/FLCN/DACT1/STK38/PTPN22/ATF3/PEBP1/LIF/DUSP21/IGBP1/PSMD10/ZMYND11/NCOR1/PAQR3 18 GO:0032722 positive regulation of chemokine production 8/1036 58/18670 0.01425 0.1585 0.14 IL6/IFNG/IL1B/TNF/LRP1/TLR3/MBP/LBP 8 GO:0006953 acute-phase response 7/1036 47/18670 0.0143 0.1585 0.14 IL1A/IL6/IL1B/HP/TNF/CD163/LBP 7 GO:0035722 interleukin-12-mediated signaling pathway 7/1036 47/18670 0.0143 0.1585 0.14 STAT4/IFNG/HNRNPF/HSPA9/IL12B/HNRNPA2B1/SOD1 7 GO:0006874 cellular calcium ion homeostasis 37/1036 458/18670 0.01433 0.1585 0.14 CD38/CXCL11/CCL5/CCR3/P2RX5/GPR18/CLIC2/ATP2A2/CXCR6/P2RX1/FYN/NTSR1/FAM155B/TRPM2/SV2A/CXCR4/LRP1/LCK/CALB2/SLC8A2/PLCB3/CCKBR/ATP1B1/ELANE/JPH3/AVPR1B/CCL11/PTGER4/ATP2B2/LPAR6/MCOLN1/NMU/TRPM1/CCL23/P2RY10/GRIN2D/ATG5 37 GO:0006937 regulation of muscle contraction 17/1036 171/18670 0.01436 0.1586 0.14 ABAT/CLIC2/ATP2A2/P2RX1/HSPB6/CHGA/PDE4B/TNNI1/SCN10A/ATP1B1/HDAC4/CHRM2/RANGRF/EHD3/SOD1/KCNQ1/NMU 17 GO:0050714 positive regulation of protein secretion 24/1036 268/18670 0.01443 0.159 0.1404 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/OXCT1/DYNLL1/CD244/TNF/PTPN22/CD2AP/LRP1/RASGRP1/DNM1L/XBP1/MBP/TRH/MAPK3/PTGER4/FCN1/NMU/SEC24A 24 GO:1903708 positive regulation of hemopoiesis 18/1036 185/18670 0.01473 0.162 0.1431 IFNG/TGFBR2/MALT1/GNAS/IL12B/TNF/ANXA1/RASGRP1/NUDT21/XBP1/IL23A/RARA/LIF/CD83/ZBTB16/IL15/HAX1/LILRB4 18 GO:0051193 regulation of cofactor metabolic process 13/1036 119/18670 0.01479 0.1622 0.1432 NUP107/IFNG/NUP37/HP/FYN/NNT/NUP205/NUP85/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 15/1036 145/18670 0.01484 0.1622 0.1432 IL6/IL1B/MALT1/TNFSF13/PRKCQ/IL12B/TNF/WAS/ANXA1/MSH2/CD1A/TBX21/IL23A/RSAD2/CLC 15 GO:0034612 response to tumor necrosis factor 27/1036 312/18670 0.01503 0.1622 0.1432 NFKB1/CCL5/RORA/PSMA2/TNFSF13/PSMA5/PSMD14/PSMA1/ZFP36/PSMC2/BIRC3/TNF/PSME4/PSMD12/PIAS4/MAPK3/PRPF8/HDAC4/PSMB1/CCL11/IGBP1/PSMD10/CCL25/CCL23/PSMC5/EDA2R/PSMA3 27 GO:0010833 telomere maintenance via telomere lengthening 10/1036 82/18670 0.0151 0.1622 0.1432 PARP1/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/RPA1/TERF1 10 GO:0016925 protein sumoylation 10/1036 82/18670 0.0151 0.1622 0.1432 NUP107/NUP37/TOLLIP/NUP205/PIAS4/NUP85/HDAC4/HMG20A/NUP160/NUP214 10 GO:0055117 regulation of cardiac muscle contraction 10/1036 82/18670 0.0151 0.1622 0.1432 CLIC2/ATP2A2/CHGA/PDE4B/SCN10A/ATP1B1/HDAC4/RANGRF/EHD3/KCNQ1 10 GO:0046885 regulation of hormone biosynthetic process 5/1036 27/18670 0.01516 0.1622 0.1432 NFKB1/IFNG/IL1B/TNF/AKR1C3 5 GO:0048143 astrocyte activation 5/1036 27/18670 0.01516 0.1622 0.1432 IL6/IFNG/IL1B/TNF/LRP1 5 GO:0001660 fever generation 3/1036 10/18670 0.01524 0.1622 0.1432 IL1A/IL1B/TNF 3 GO:0006930 substrate-dependent cell migration, cell extension 3/1036 10/18670 0.01524 0.1622 0.1432 NCK1/CD2AP/NTN1 3 GO:0030647 aminoglycoside antibiotic metabolic process 3/1036 10/18670 0.01524 0.1622 0.1432 AKR7A2/AKR1B1/AKR1C3 3 GO:0032070 regulation of deoxyribonuclease activity 3/1036 10/18670 0.01524 0.1622 0.1432 PCNA/GZMA/NPM1 3 GO:0039530 MDA-5 signaling pathway 3/1036 10/18670 0.01524 0.1622 0.1432 C1QBP/DDX60/ANKRD17 3 GO:0042758 long-chain fatty acid catabolic process 3/1036 10/18670 0.01524 0.1622 0.1432 LIPE/CYP4A11/CYP4F12 3 GO:0070091 glucagon secretion 3/1036 10/18670 0.01524 0.1622 0.1432 IL6/PASK/AIMP1 3 GO:2000628 regulation of miRNA metabolic process 3/1036 10/18670 0.01524 0.1622 0.1432 DROSHA/NFKB1/KHSRP 3 GO:0038083 peptidyl-tyrosine autophosphorylation 6/1036 37/18670 0.01528 0.1624 0.1434 FYN/TXK/ITK/LCK/MAPK3/DYRK1A 6 GO:0051957 positive regulation of amino acid transport 4/1036 18/18670 0.01544 0.1631 0.144 ABAT/KMO/NTSR1/TRH 4 GO:0150078 positive regulation of neuroinflammatory response 4/1036 18/18670 0.01544 0.1631 0.144 IL6/IL1B/CTSC/TNF 4 GO:2000319 regulation of T-helper 17 cell differentiation 4/1036 18/18670 0.01544 0.1631 0.144 MALT1/IL12B/TBX21/IL23A 4 GO:0032890 regulation of organic acid transport 8/1036 59/18670 0.01571 0.1651 0.1458 ABAT/IL1B/KMO/NTSR1/SV2A/TRH/NCOR1/CYP4A11 8 GO:0033619 membrane protein proteolysis 8/1036 59/18670 0.01571 0.1651 0.1458 NFKB1/IFNG/IL1B/PRKCQ/TNF/APH1B/TIMP2/TIMP4 8 GO:0006140 regulation of nucleotide metabolic process 15/1036 146/18670 0.01572 0.1651 0.1458 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/DNM1L/NUP85/SPHK2/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0001774 microglial cell activation 7/1036 48/18670 0.01597 0.1663 0.1469 IL6/IFNG/CTSC/TNF/TLR3/CST7/TLR6 7 GO:0002269 leukocyte activation involved in inflammatory response 7/1036 48/18670 0.01597 0.1663 0.1469 IL6/IFNG/CTSC/TNF/TLR3/CST7/TLR6 7 GO:0002711 positive regulation of T cell mediated immunity 7/1036 48/18670 0.01597 0.1663 0.1469 IL6/IL1B/MALT1/IL12B/CD1A/IL23A/RSAD2 7 GO:0051972 regulation of telomerase activity 7/1036 48/18670 0.01597 0.1663 0.1469 MYC/PRKCQ/CCT2/MAPK3/TNKS/HNRNPA2B1/TERF1 7 GO:0042102 positive regulation of T cell proliferation 11/1036 95/18670 0.01603 0.1663 0.1469 CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/ANXA1/IL23A/IL15/CD3E 11 GO:0044070 regulation of anion transport 11/1036 95/18670 0.01603 0.1663 0.1469 ABAT/ABCB1/IL1B/KMO/NTSR1/SV2A/ATP8A1/TRH/CA7/NCOR1/CYP4A11 11 GO:0002237 response to molecule of bacterial origin 29/1036 343/18670 0.01613 0.167 0.1475 CD96/CXCL11/NFKB1/CCL5/IL6/CTR9/IL1B/MALT1/HNRNPA0/ATP2A2/KMO/IL12B/ZFP36/PDE4B/TNF/PTPN22/IL36A/XBP1/RARA/MAPK3/PRPF8/ELANE/TIMP4/PTGER4/TLR6/CTSG/RPS6KA3/BCR/LBP 29 GO:0010498 proteasomal protein catabolic process 38/1036 477/18670 0.01618 0.1673 0.1477 RCHY1/SKP1/PPP2R5C/USP25/CDC23/PSMA2/LAMP3/ANAPC5/PSMA5/DERL1/PSMD14/PSMA1/PSMC2/GCLC/SIAH2/RBX1/PSME4/CD2AP/TRIB2/PSMD12/TBX21/EDEM1/HECTD3/UBA52/PSMB1/FBXO5/PSMD10/CUL1/WAC/UBB/PMAIP1/RPL11/RNF4/HERC2/RCN3/UBE2J1/PSMC5/PSMA3 38 GO:0042795 snRNA transcription by RNA polymerase II 9/1036 71/18670 0.01631 0.1677 0.1481 POU2F2/INTS12/GTF2A2/INTS8/ICE1/TBP/ICE2/TAF5/GTF2E1 9 GO:0002819 regulation of adaptive immune response 16/1036 160/18670 0.01635 0.1677 0.1481 IL6/IL1B/MALT1/TNFSF13/PRKCQ/IL12B/TNF/WAS/ANXA1/MSH2/CD1A/TBX21/CD48/IL23A/RSAD2/CLC 16 GO:0006754 ATP biosynthetic process 16/1036 160/18670 0.01635 0.1677 0.1481 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/CYC1/NUP85/SPHK2/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 16 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 10/1036 83/18670 0.01635 0.1677 0.1481 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/IL15/IL3 10 GO:0051098 regulation of binding 31/1036 373/18670 0.01647 0.1686 0.1489 AIDA/PARP1/IFNG/DACT1/ITGA4/CLIC2/LDLRAP1/EIF4A3/DERL1/IFIT2/PLCL1/CAPRIN2/TGFBR3/GZMA/MAP2/LRP1/ARHGEF7/SMARCD3/GMNN/RARA/MAPK3/LIF/TNKS/HDAC4/PON1/RPL11/ADAM15/ADNP/CCL23/CRMP1/ZBTB7A 31 GO:0072503 cellular divalent inorganic cation homeostasis 39/1036 493/18670 0.01661 0.1691 0.1493 CD38/CXCL11/CCL5/CCR3/P2RX5/GPR18/CLIC2/ATP2A2/CXCR6/P2RX1/FYN/NTSR1/FAM155B/TRPM2/SV2A/CXCR4/LRP1/LCK/CALB2/SLC8A2/PLCB3/CCKBR/ATP1B1/ELANE/SLC30A9/JPH3/AVPR1B/CCL11/PTGER4/ATP2B2/LPAR6/MCOLN1/NMU/TRPM1/CCL23/P2RY10/SLC39A6/GRIN2D/ATG5 39 GO:0019359 nicotinamide nucleotide biosynthetic process 15/1036 147/18670 0.01664 0.1691 0.1493 PGK1/NUP107/IFNG/NUP37/KMO/NUP205/NUP85/SLC22A13/KYNU/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0019363 pyridine nucleotide biosynthetic process 15/1036 147/18670 0.01664 0.1691 0.1493 PGK1/NUP107/IFNG/NUP37/KMO/NUP205/NUP85/SLC22A13/KYNU/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:1901657 glycosyl compound metabolic process 15/1036 147/18670 0.01664 0.1691 0.1493 PRPS2/DCK/DERA/CMPK1/ENPP4/PRPS1/MFN1/UCKL1/AHCY/AKR7A2/AKR1B1/APOBEC3G/AKR1C3/PRPSAP2/APRT 15 GO:0006165 nucleoside diphosphate phosphorylation 14/1036 134/18670 0.01681 0.1704 0.1505 PGK1/NUP107/IFNG/CMPK1/NUP37/NUP205/NUP85/HDAC4/SUCLG1/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 14 GO:0032496 response to lipopolysaccharide 28/1036 330/18670 0.0171 0.1729 0.1527 CD96/CXCL11/NFKB1/CCL5/IL6/CTR9/IL1B/MALT1/HNRNPA0/ATP2A2/KMO/IL12B/ZFP36/PDE4B/TNF/PTPN22/IL36A/XBP1/RARA/MAPK3/PRPF8/ELANE/TIMP4/PTGER4/CTSG/RPS6KA3/BCR/LBP 28 GO:1901292 nucleoside phosphate catabolic process 18/1036 188/18670 0.01712 0.1729 0.1527 HINT1/PGK1/NUP107/IFNG/DERA/NUP37/PDE4B/NUP205/NUP85/HDAC4/PDE8A/PFKP/NUDT9/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 18 GO:0033108 mitochondrial respiratory chain complex assembly 11/1036 96/18670 0.01723 0.1732 0.153 TMEM126B/UQCRB/FASTKD3/NDUFV1/NDUFV2/NDUFA10/NDUFA6/NDUFB4/OXA1L/NDUFS1/NDUFS4 11 GO:0048010 vascular endothelial growth factor receptor signaling pathway 11/1036 96/18670 0.01723 0.1732 0.153 IL1B/NCK1/TMEM204/SH2D2A/FYN/CYFIP2/SULF1/PIK3CA/ELMO2/FGF18/PIK3R1 11 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 34/1036 419/18670 0.01727 0.1732 0.153 RCHY1/SKP1/PPP2R5C/CDC23/PSMA2/ANAPC5/PSMA5/DERL1/PSMD14/PSMA1/PSMC2/GCLC/SIAH2/RBX1/PSME4/CD2AP/TRIB2/PSMD12/TBX21/EDEM1/HECTD3/UBA52/PSMB1/FBXO5/PSMD10/CUL1/WAC/UBB/RPL11/RNF4/HERC2/UBE2J1/PSMC5/PSMA3 34 GO:0043486 histone exchange 8/1036 60/18670 0.01728 0.1732 0.153 ITGB3BP/ACTR6/RBBP4/PSME4/NPM1/RBBP7/ZNHIT1/SMARCA5 8 GO:0006084 acetyl-CoA metabolic process 6/1036 38/18670 0.01732 0.1733 0.1531 DLD/PDHX/PPCS/KYNU/PDHB/ACAT1 6 GO:0050686 negative regulation of mRNA processing 5/1036 28/18670 0.01764 0.1755 0.155 CTR9/C1QBP/SRSF10/HNRNPA2B1/DYRK1A 5 GO:0051123 RNA polymerase II preinitiation complex assembly 5/1036 28/18670 0.01764 0.1755 0.155 GTF2A2/PSMC2/TBP/TAF12/PSMC5 5 GO:1902932 positive regulation of alcohol biosynthetic process 5/1036 28/18670 0.01764 0.1755 0.155 IFNG/IL1B/CD244/NTSR1/TNF 5 GO:0071349 cellular response to interleukin-12 7/1036 49/18670 0.01776 0.1765 0.1558 STAT4/IFNG/HNRNPF/HSPA9/IL12B/HNRNPA2B1/SOD1 7 GO:0034599 cellular response to oxidative stress 26/1036 302/18670 0.0178 0.1765 0.1559 PCNA/PARP1/IL6/SFPQ/CAT/ATP2A2/SOD3/MTR/CYCS/FYN/TNF/TRPM2/RWDD1/ANXA1/LANCL1/PRKRA/MAPK3/PDE8A/TLR6/GPX7/AKR1C3/ALDH3B1/PRDX6/SETX/SOD1/CBX8 26 GO:0015718 monocarboxylic acid transport 16/1036 162/18670 0.01819 0.18 0.159 ABAT/ABCD3/IL1B/NTSR1/SV2A/ANXA1/TRH/SLC10A2/SLC22A13/ABCC4/SLC16A6/ACSL3/PLA2G3/NCOR1/SLC16A5/CYP4A11 16 GO:0006942 regulation of striated muscle contraction 11/1036 97/18670 0.01849 0.1822 0.1609 CLIC2/ATP2A2/CHGA/PDE4B/TNNI1/SCN10A/ATP1B1/HDAC4/RANGRF/EHD3/KCNQ1 11 GO:0030316 osteoclast differentiation 11/1036 97/18670 0.01849 0.1822 0.1609 IFNG/GNAS/IL12B/TNF/GLO1/TLR3/IL23A/LILRB3/GPR183/LILRB4/PIK3R1 11 GO:0002363 alpha-beta T cell lineage commitment 4/1036 19/18670 0.01872 0.1822 0.1609 IL6/IL12B/TBX21/IL23A 4 GO:0002544 chronic inflammatory response 4/1036 19/18670 0.01872 0.1822 0.1609 CCL5/TNF/AHCY/CCL11 4 GO:0002726 positive regulation of T cell cytokine production 4/1036 19/18670 0.01872 0.1822 0.1609 IL6/IL1B/MALT1/RSAD2 4 GO:0046641 positive regulation of alpha-beta T cell proliferation 4/1036 19/18670 0.01872 0.1822 0.1609 TGFBR2/IL12B/IL23A/CD3E 4 GO:0048025 negative regulation of mRNA splicing, via spliceosome 4/1036 19/18670 0.01872 0.1822 0.1609 C1QBP/SRSF10/HNRNPA2B1/DYRK1A 4 GO:1900409 positive regulation of cellular response to oxidative stress 4/1036 19/18670 0.01872 0.1822 0.1609 SFPQ/TNF/TLR6/SOD1 4 GO:2000010 positive regulation of protein localization to cell surface 4/1036 19/18670 0.01872 0.1822 0.1609 CD247/TNF/GPD1L/RANGRF 4 GO:0097193 intrinsic apoptotic signaling pathway 25/1036 289/18670 0.01883 0.1826 0.1612 PARP1/DYRK2/HINT1/SFPQ/FLCN/MOAP1/NCK1/BCLAF1/TNF/RPS7/DAPK2/MSH2/PRKRA/DNM1L/LCK/XBP1/PIAS4/STK11/CUL1/UBB/PMAIP1/RPL11/SOD1/PIK3R1/EDA2R 25 GO:0046939 nucleotide phosphorylation 14/1036 136/18670 0.0189 0.1826 0.1612 PGK1/NUP107/IFNG/CMPK1/NUP37/NUP205/NUP85/HDAC4/SUCLG1/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 14 GO:0030521 androgen receptor signaling pathway 8/1036 61/18670 0.01895 0.1826 0.1612 TRIM68/RWDD1/NCOA3/KDM5D/DAXX/RNF4/NCOR1/ZBTB7A 8 GO:0032370 positive regulation of lipid transport 8/1036 61/18670 0.01895 0.1826 0.1612 IL1B/LDLRAP1/NTSR1/ATP8A1/LRP1/SCP2/PON1/CYP4A11 8 GO:0045123 cellular extravasation 8/1036 61/18670 0.01895 0.1826 0.1612 MADCAM1/ITGA4/TNF/ELANE/CD99/PTGER4/CCL25/BCR 8 GO:0002573 myeloid leukocyte differentiation 19/1036 204/18670 0.019 0.1826 0.1612 PARP1/MYC/IFNG/TGFBR2/GNAS/IL12B/TNF/GLO1/TLR3/IL23A/RARA/LILRB3/LIF/GPR183/SPI1/IL15/HAX1/LILRB4/PIK3R1 19 GO:0031396 regulation of protein ubiquitination 19/1036 204/18670 0.019 0.1826 0.1612 RCHY1/CTR9/MALT1/DERL1/GCLC/FYN/CRY1/BIRC3/SIAH2/PTPN22/TRIM44/RPS7/DNM1L/FBXO5/PSMD10/DAXX/UBB/RPL11/ATG5 19 GO:0006283 transcription-coupled nucleotide-excision repair 9/1036 73/18670 0.01928 0.1839 0.1624 PCNA/TCEA1/COPS4/RBX1/GTF2H3/UBA52/HMGN1/UBB/RPA1 9 GO:0044766 multi-organism transport 9/1036 73/18670 0.01928 0.1839 0.1624 NUP107/NUP37/NUP205/NUP85/UBA52/VPS37B/UBB/NUP160/NUP214 9 GO:1901983 regulation of protein acetylation 9/1036 73/18670 0.01928 0.1839 0.1624 AUTS2/BRD7/IL1B/FLCN/MAPK3/LIF/SPHK2/SPI1/ATG5 9 GO:1902579 multi-organism localization 9/1036 73/18670 0.01928 0.1839 0.1624 NUP107/NUP37/NUP205/NUP85/UBA52/VPS37B/UBB/NUP160/NUP214 9 GO:0045862 positive regulation of proteolysis 30/1036 363/18670 0.01938 0.1839 0.1624 MYC/IFNG/RCHY1/IL1B/MALT1/CTSC/CTSD/PLGRKT/PSMD14/P2RX1/PSMC2/CYCS/SART3/GCLC/FYN/TNF/F12/RBX1/PSME4/TRIB2/CYFIP2/LCK/EDEM1/PCOLCE/MBP/HSPE1/MAPK3/PSMD10/PMAIP1/RCN3 30 GO:0009201 ribonucleoside triphosphate biosynthetic process 17/1036 177/18670 0.01956 0.1839 0.1624 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/UCKL1/CYC1/NUP85/SPHK2/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 17 GO:0097237 cellular response to toxic substance 22/1036 247/18670 0.01964 0.1839 0.1624 PCNA/NFKB1/IL6/CAT/CLIC2/SOD3/SESN1/HP/TNF/TRPM2/NNT/ANXA1/GLRA1/PDE8A/SPI1/GPX7/PRDX6/DAXX/SETX/SOD1/IPCEF1/CBX8 22 GO:0008203 cholesterol metabolic process 15/1036 150/18670 0.01965 0.1839 0.1624 IDI1/MSMO1/CETP/CAT/INSIG1/LDLRAP1/NPC1/FDX1/LIPE/NFYB/PON1/CH25H/SC5D/SOD1/CNBP 15 GO:0031123 RNA 3'-end processing 15/1036 150/18670 0.01965 0.1839 0.1624 CTR9/FBL/INTS12/EIF4A3/INTS8/PCF11/EXOSC8/POLR3K/NUDT21/CSTF2T/PABPC1/CDC40/RPS21/RBM8A/UPF3B 15 GO:0072525 pyridine-containing compound biosynthetic process 15/1036 150/18670 0.01965 0.1839 0.1624 PGK1/NUP107/IFNG/NUP37/KMO/NUP205/NUP85/SLC22A13/KYNU/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0032873 negative regulation of stress-activated MAPK cascade 7/1036 50/18670 0.0197 0.1839 0.1624 AIDA/MYC/DACT1/PTPN22/IGBP1/ZMYND11/NCOR1 7 GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 7/1036 50/18670 0.0197 0.1839 0.1624 AIDA/MYC/DACT1/PTPN22/IGBP1/ZMYND11/NCOR1 7 GO:0070671 response to interleukin-12 7/1036 50/18670 0.0197 0.1839 0.1624 STAT4/IFNG/HNRNPF/HSPA9/IL12B/HNRNPA2B1/SOD1 7 GO:0031667 response to nutrient levels 39/1036 499/18670 0.01976 0.1839 0.1624 PCNA/ATG14/HAT1/TGFBR2/IL1B/P2RX5/OXCT1/CAT/HSD11B2/SESN1/P2RX1/ZFP36/GCLC/FYN/TMEM135/ATF3/NNT/DNM1L/ADSL/XBP1/AHCY/USF2/RARA/MAPK3/TNKS/KYNU/PON1/OTC/AKR1C3/P2RX6/IL15/PMAIP1/SOD1/ACSL3/TRIM24/CD3E/SLC38A2/ACAT1/ATG5 39 GO:0050764 regulation of phagocytosis 11/1036 98/18670 0.01982 0.1839 0.1624 IFNG/IL2RB/IL1B/PTX3/TNF/LRP1/IL15RA/IL15/SOD1/BCR/ATG5 11 GO:0006066 alcohol metabolic process 30/1036 364/18670 0.02004 0.1839 0.1624 NFKB1/IFNG/IL1B/IDI1/MSMO1/CETP/CAT/INSIG1/LDLRAP1/NPC1/CD244/NTSR1/PLCL1/TNF/FDX1/LIPE/NFYB/QDPR/AKR7A2/PLCB3/SPHK2/PON1/CH25H/AKR1B1/AKR1C3/ALDH3B1/RDH16/SC5D/SOD1/CNBP 30 GO:0016570 histone modification 36/1036 454/18670 0.02009 0.1839 0.1624 AUTS2/BRD7/HAT1/CTR9/IL1B/SFPQ/FLCN/SKP1/FBL/AURKC/SUPT7L/TRIM37/SART3/USP16/YEATS2/NCOA3/MAPK3/LIF/SPHK2/HDAC4/VRK1/BRD1/KDM5C/SPI1/KDM5D/TAF5/WAC/CPA4/KANSL2/ZNHIT1/ATRX/TAF12/SATB1/CBX8/KAT8/ATG5 36 GO:0000185 activation of MAPKKK activity 3/1036 11/18670 0.0201 0.1839 0.1624 TNF/MAP4K5/MAP4K2 3 GO:0000491 small nucleolar ribonucleoprotein complex assembly 3/1036 11/18670 0.0201 0.1839 0.1624 ZNHIT3/ZNHIT6/SHQ1 3 GO:0002328 pro-B cell differentiation 3/1036 11/18670 0.0201 0.1839 0.1624 SOS1/FLCN/NUDT21 3 GO:0002730 regulation of dendritic cell cytokine production 3/1036 11/18670 0.0201 0.1839 0.1624 DDX1/DDX21/TLR3 3 GO:0033235 positive regulation of protein sumoylation 3/1036 11/18670 0.0201 0.1839 0.1624 TOLLIP/PIAS4/HDAC4 3 GO:0046886 positive regulation of hormone biosynthetic process 3/1036 11/18670 0.0201 0.1839 0.1624 IFNG/IL1B/TNF 3 GO:0046950 cellular ketone body metabolic process 3/1036 11/18670 0.0201 0.1839 0.1624 OXCT1/ACSS3/ACAT1 3 GO:0070203 regulation of establishment of protein localization to telomere 3/1036 11/18670 0.0201 0.1839 0.1624 CCT7/CCT2/TERF1 3 GO:0070213 protein auto-ADP-ribosylation 3/1036 11/18670 0.0201 0.1839 0.1624 PARP1/PARP11/TNKS 3 GO:2000551 regulation of T-helper 2 cell cytokine production 3/1036 11/18670 0.0201 0.1839 0.1624 IL6/TBX21/RSAD2 3 GO:0006406 mRNA export from nucleus 12/1036 111/18670 0.02017 0.1839 0.1624 NUP107/NUP37/EIF4A3/NUP205/NUP85/HNRNPA2B1/RBM15B/CDC40/NUP160/NUP214/RBM8A/UPF3B 12 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 12/1036 111/18670 0.02017 0.1839 0.1624 NUP107/NUP37/EIF4A3/NUP205/NUP85/HNRNPA2B1/RBM15B/CDC40/NUP160/NUP214/RBM8A/UPF3B 12 GO:0072676 lymphocyte migration 12/1036 111/18670 0.02017 0.1839 0.1624 CXCL11/CCL5/MADCAM1/ITGA4/ARTN/TBX21/CH25H/CD99/CCL11/GPR183/CCL25/CCL23 12 GO:0010575 positive regulation of vascular endothelial growth factor production 5/1036 29/18670 0.02037 0.1845 0.1629 IL1A/IL6/IL1B/RORA/SULF1 5 GO:0035666 TRIF-dependent toll-like receptor signaling pathway 5/1036 29/18670 0.02037 0.1845 0.1629 BIRC3/TLR3/UBA52/TLR6/UBB 5 GO:0060765 regulation of androgen receptor signaling pathway 5/1036 29/18670 0.02037 0.1845 0.1629 TRIM68/RWDD1/KDM5D/NCOR1/ZBTB7A 5 GO:1902624 positive regulation of neutrophil migration 5/1036 29/18670 0.02037 0.1845 0.1629 C1QBP/DAPK2/IL23A/CD99/LBP 5 GO:0043543 protein acylation 22/1036 248/18670 0.02047 0.1851 0.1634 AUTS2/BRD7/HAT1/ZDHHC4/IL1B/FLCN/DLD/SUPT7L/YEATS2/NCOA3/MAPK3/LIF/SPHK2/BRD1/ATAT1/SPI1/TAF5/CPA4/KANSL2/TAF12/KAT8/ATG5 22 GO:0007260 tyrosine phosphorylation of STAT protein 10/1036 86/18670 0.02053 0.1851 0.1635 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/IL15/IL3 10 GO:0090090 negative regulation of canonical Wnt signaling pathway 17/1036 178/18670 0.02055 0.1851 0.1635 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/RBX1/PSME4/PSMD12/MLLT3/PSMB1/BICC1/STK11/PSMD10/PSMC5/PSMA3 17 GO:0031640 killing of cells of other organism 8/1036 62/18670 0.02073 0.186 0.1643 IFNG/LYZ/HMGN2/PRF1/CHGA/ELANE/CTSG/PGLYRP4 8 GO:0044364 disruption of cells of other organism 8/1036 62/18670 0.02073 0.186 0.1643 IFNG/LYZ/HMGN2/PRF1/CHGA/ELANE/CTSG/PGLYRP4 8 GO:0007565 female pregnancy 18/1036 192/18670 0.02075 0.186 0.1643 CD38/TGFBR2/IL1B/C1QBP/UBE2Q1/HSD11B2/POLR1B/RECK/EMP2/RARA/MAPK3/LIF/SPHK2/AKR1B1/RPL29/SOD1/SLC38A2/TMED2 18 GO:0014015 positive regulation of gliogenesis 9/1036 74/18670 0.02091 0.1868 0.165 IL6/IL1B/PRKCH/PPP1CC/TNF/CXCR4/LRP1/SPINT1/LIF 9 GO:1900182 positive regulation of protein localization to nucleus 9/1036 74/18670 0.02091 0.1868 0.165 PARP1/IFNG/CCT7/FYN/CCT2/CD2AP/LIF/STK11/PIK3R1 9 GO:2001242 regulation of intrinsic apoptotic signaling pathway 16/1036 165/18670 0.02125 0.1896 0.1674 PARP1/SFPQ/FLCN/NCK1/BCLAF1/RPS7/DAPK2/PRKRA/DNM1L/LCK/XBP1/PIAS4/UBB/PMAIP1/RPL11/SOD1 16 GO:0031050 dsRNA processing 7/1036 51/18670 0.02178 0.1933 0.1707 DROSHA/SNIP1/PPP1R8/PRKRA/PUM1/HNRNPA2B1/NCOR1 7 GO:0070918 production of small RNA involved in gene silencing by RNA 7/1036 51/18670 0.02178 0.1933 0.1707 DROSHA/SNIP1/PPP1R8/PRKRA/PUM1/HNRNPA2B1/NCOR1 7 GO:0072523 purine-containing compound catabolic process 7/1036 51/18670 0.02178 0.1933 0.1707 HINT1/ENPP4/PDE4B/AHCY/PDE8A/NUDT9/ACAT1 7 GO:0008156 negative regulation of DNA replication 6/1036 40/18670 0.02194 0.1941 0.1714 S100A11/ATR/GMNN/FBXO5/TERF1/DONSON 6 GO:0042036 negative regulation of cytokine biosynthetic process 6/1036 40/18670 0.02194 0.1941 0.1714 NFKB1/IL6/ZFP36/TIA1/TRIB2/ELANE 6 GO:0002449 lymphocyte mediated immunity 29/1036 352/18670 0.02204 0.1947 0.1719 CD96/IL6/SH2D1A/KLRD1/IL1B/C1QBP/POU2F2/MALT1/BTN3A3/CTSC/TNFSF13/IL12B/HLA-DQB1/PRF1/GZMB/CD8A/TNF/C8B/WAS/MSH2/CD1A/RASGRP1/TBX21/EMP2/IL23A/RSAD2/RFTN1/TRBC1/CLC 29 GO:0009895 negative regulation of catabolic process 26/1036 308/18670 0.02221 0.1949 0.1721 IL1B/USP25/LAMP3/CRTC3/HNRNPA0/NPC1/ZFP36/HP/SCFD1/FYN/HERC1/TNF/PTPN22/RPS7/PAIP1/CSNK2A2/ELAVL1/PIK3CA/PABPC1/TIMP2/HDAC4/TIMP4/WAC/RPL11/UBE2J1/FEZ1 26 GO:0016125 sterol metabolic process 16/1036 166/18670 0.02235 0.1949 0.1721 IDI1/MSMO1/CETP/LIPA/CAT/INSIG1/LDLRAP1/NPC1/FDX1/LIPE/NFYB/PON1/CH25H/SC5D/SOD1/CNBP 16 GO:0050715 positive regulation of cytokine secretion 14/1036 139/18670 0.0224 0.1949 0.1721 IL1A/IFNG/CD2/IL1B/CD244/TNF/PTPN22/LRP1/RASGRP1/XBP1/MBP/MAPK3/PTGER4/FCN1 14 GO:0002320 lymphoid progenitor cell differentiation 4/1036 20/18670 0.0224 0.1949 0.1721 SOS1/FLCN/NUDT21/SPI1 4 GO:0002374 cytokine secretion involved in immune response 4/1036 20/18670 0.0224 0.1949 0.1721 TNF/MAPK3/SPHK2/ATG5 4 GO:0002827 positive regulation of T-helper 1 type immune response 4/1036 20/18670 0.0224 0.1949 0.1721 IL1B/IL12B/ANXA1/IL23A 4 GO:0032816 positive regulation of natural killer cell activation 4/1036 20/18670 0.0224 0.1949 0.1721 IL12B/RASGRP1/IL23A/IL15 4 GO:0042276 error-prone translesion synthesis 4/1036 20/18670 0.0224 0.1949 0.1721 PCNA/UBA52/UBB/RPA1 4 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 4/1036 20/18670 0.0224 0.1949 0.1721 IL6/IL12B/TBX21/IL23A 4 GO:0150076 neuroinflammatory response 9/1036 75/18670 0.02263 0.1963 0.1733 IL6/IFNG/IL1B/CTSC/TNF/LRP1/TLR3/CST7/TLR6 9 GO:1904377 positive regulation of protein localization to cell periphery 8/1036 63/18670 0.02264 0.1963 0.1733 IFNG/PRKCH/TNF/LRP1/ANXA13/RANGRF/ACSL3/PIK3R1 8 GO:1901605 alpha-amino acid metabolic process 20/1036 222/18670 0.02266 0.1963 0.1733 SLC25A32/DLD/SEPHS1/PLOD1/ODC1/KMO/MTR/GCLC/QDPR/AHCY/MCCC1/KYNU/OTC/CBS/ASNSD1/AASDHPPT/GAD2/ACAT1/SLC1A3/GFPT1 20 GO:0046031 ADP metabolic process 13/1036 126/18670 0.02275 0.1967 0.1737 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NUDT9/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0051047 positive regulation of secretion 34/1036 428/18670 0.02282 0.197 0.174 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/OXCT1/KMO/DYNLL1/CD244/NTSR1/TNF/PTPN22/CD2AP/LRP1/RASGRP1/DNM1L/XBP1/RAB9A/MBP/TRH/MAPK3/SPHK2/AIMP1/PTGER4/CLASP1/GHRHR/FCN1/ACSL3/NMU/CYP4A11/SEC24A/ATG5 34 GO:0030168 platelet activation 15/1036 153/18670 0.02306 0.1988 0.1755 ABAT/IL6/PRKCH/METAP1/PRKCQ/GNAS/P2RX1/FYN/CLEC1B/LCK/PIK3CA/MAPK3/DGKZ/CD9/PIK3R1 15 GO:0045637 regulation of myeloid cell differentiation 22/1036 251/18670 0.02311 0.1988 0.1756 MYC/IFNG/GPR171/CTR9/PRKCQ/GNAS/HSPA9/IL12B/ZFP36/TNF/TLR3/IL23A/RARA/LILRB3/LIF/RBM15/ZBTB16/SPI1/HAX1/LILRB4/PIK3R1/NCAPG2 22 GO:0009152 purine ribonucleotide biosynthetic process 24/1036 280/18670 0.0232 0.1993 0.176 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/DLD/PDHX/PPCS/NUP205/ADSL/CYC1/NUP85/SPHK2/HDAC4/PFKP/ACSL3/PDHB/APRT/NCOR1/NUP160/ACAT1/NUP214/ZBTB7A 24 GO:0000027 ribosomal large subunit assembly 5/1036 30/18670 0.02335 0.2 0.1766 RPL6/MDN1/RSL24D1/RRS1/RPL11 5 GO:0002828 regulation of type 2 immune response 5/1036 30/18670 0.02335 0.2 0.1766 IL6/ANXA1/TBX21/RARA/RSAD2 5 GO:0071496 cellular response to external stimulus 28/1036 339/18670 0.02344 0.2004 0.177 NFKB1/ATG14/IL1B/ITGA4/ITGA6/SESN1/GCLC/PIEZO2/FYN/ATF3/DNM1L/TLR3/ASGR1/XBP1/USF2/MAPK3/TNKS/HDAC4/PTGER4/CBS/AKR1C3/IL15/PMAIP1/SOD1/TRIM24/SLC38A2/ADNP/ATG5 28 GO:0033209 tumor necrosis factor-mediated signaling pathway 16/1036 167/18670 0.0235 0.2006 0.1771 PSMA2/TNFSF13/PSMA5/PSMD14/PSMA1/PSMC2/BIRC3/TNF/PSME4/PSMD12/PIAS4/PSMB1/PSMD10/PSMC5/EDA2R/PSMA3 16 GO:0006767 water-soluble vitamin metabolic process 10/1036 88/18670 0.02373 0.2014 0.1779 SLC25A32/KMO/MTR/GCLC/MCCC1/KYNU/LMBRD1/CYB5A/AASDHPPT/TCN2 10 GO:0043470 regulation of carbohydrate catabolic process 10/1036 88/18670 0.02373 0.2014 0.1779 NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 10 GO:0050829 defense response to Gram-negative bacterium 10/1036 88/18670 0.02373 0.2014 0.1779 DROSHA/OPTN/IL6/LYZ/IL12B/CHGA/IL23A/ELANE/CTSG/LBP 10 GO:0002285 lymphocyte activation involved in immune response 17/1036 181/18670 0.02374 0.2014 0.1779 ITM2A/IL6/IFNG/MALT1/RORA/TNFSF13/IL12B/CD244/ANXA1/MSH2/TBX21/XBP1/IL23A/RARA/PTGER4/GPR183/PGLYRP4 17 GO:0016073 snRNA metabolic process 11/1036 101/18670 0.02424 0.2053 0.1813 POU2F2/INTS12/GTF2A2/INTS8/EXOSC8/USPL1/ICE1/TBP/ICE2/TAF5/GTF2E1 11 GO:0001818 negative regulation of cytokine production 25/1036 296/18670 0.02444 0.2064 0.1823 CD96/SLAMF1/NFKB1/IL6/IFNG/C1QBP/GPR18/IL12B/ZFP36/TNF/PTPN22/TIA1/CD2AP/TRIB2/ANXA1/TBX21/IL23A/RARA/CD83/ELANE/PTGER4/TLR6/PGLYRP4/GPATCH3/LBP 25 GO:0019674 NAD metabolic process 9/1036 76/18670 0.02445 0.2064 0.1823 CD38/MDH1/PGK1/LDHB/KMO/GPD1L/SLC22A13/KYNU/PFKP 9 GO:0030178 negative regulation of Wnt signaling pathway 19/1036 210/18670 0.02485 0.2095 0.185 DACT1/PSMA2/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/RBX1/PSME4/PSMD12/LRP1/MLLT3/HMGXB4/PSMB1/BICC1/STK11/PSMD10/PSMC5/PSMA3 19 GO:1902652 secondary alcohol metabolic process 15/1036 155/18670 0.02557 0.214 0.189 IDI1/MSMO1/CETP/CAT/INSIG1/LDLRAP1/NPC1/FDX1/LIPE/NFYB/PON1/CH25H/SC5D/SOD1/CNBP 15 GO:0002371 dendritic cell cytokine production 3/1036 12/18670 0.02571 0.214 0.189 DDX1/DDX21/TLR3 3 GO:0051132 NK T cell activation 3/1036 12/18670 0.02571 0.214 0.189 IL12B/IL23A/IL15 3 GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/1036 12/18670 0.02571 0.214 0.189 BTG2/ZFP36/PABPC1 3 GO:0070202 regulation of establishment of protein localization to chromosome 3/1036 12/18670 0.02571 0.214 0.189 CCT7/CCT2/TERF1 3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 3/1036 12/18670 0.02571 0.214 0.189 NCK1/DNAJB1/CITED2 3 GO:1902224 ketone body metabolic process 3/1036 12/18670 0.02571 0.214 0.189 OXCT1/ACSS3/ACAT1 3 GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 3/1036 12/18670 0.02571 0.214 0.189 TNF/LRP1/MBP 3 GO:0006096 glycolytic process 12/1036 115/18670 0.02584 0.2145 0.1894 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 12 GO:0098869 cellular oxidant detoxification 11/1036 102/18670 0.02586 0.2145 0.1894 CAT/CLIC2/SOD3/SESN1/HP/TNF/NNT/GPX7/PRDX6/SOD1/IPCEF1 11 GO:0051480 regulation of cytosolic calcium ion concentration 29/1036 357/18670 0.02599 0.2145 0.1894 CD38/CXCL11/CCR3/P2RX5/GPR18/CLIC2/CXCR6/P2RX1/FYN/NTSR1/FAM155B/TRPM2/CXCR4/LRP1/LCK/CALB2/PLCB3/CCKBR/JPH3/AVPR1B/PTGER4/ATP2B2/LPAR6/MCOLN1/NMU/TRPM1/P2RY10/GRIN2D/ATG5 29 GO:0006790 sulfur compound metabolic process 30/1036 372/18670 0.02602 0.2145 0.1894 ISCA1/SLC35D1/NFU1/SUCLA2/ADO/OPLAH/DLD/CHST12/HSPA9/MTR/PDHX/GCLC/MICAL1/PPCS/CHPF2/GLO1/AHCY/SUCLG2/TPST1/MCCC1/KYNU/SUCLG1/GSTT2/CBS/SOD1/ACSL3/PDHB/B3GNT2/GSTA3/ACAT1 30 GO:0002221 pattern recognition receptor signaling pathway 18/1036 197/18670 0.02608 0.2145 0.1894 C1QBP/BIRC3/PTPN22/DDX60/ANKRD17/TLR3/PUM1/RSAD2/UBA52/RFTN1/ALPK1/TLR6/FCN1/UBB/RPS6KA3/PGLYRP4/GPATCH3/LBP 18 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 17/1036 183/18670 0.02608 0.2145 0.1894 IL1B/APOL3/MALT1/FYN/BIRC3/TNF/TRAF5/ANKRD17/IL36A/DDX1/DDX21/TLR3/ALPK1/TLR6/ROR1/SLC20A1/EDA2R 17 GO:0006968 cellular defense response 7/1036 53/18670 0.02637 0.2145 0.1894 SH2D1A/CCR3/TRAT1/PRF1/ITK/CD5L/LBP 7 GO:1901224 positive regulation of NIK/NF-kappaB signaling 9/1036 77/18670 0.02638 0.2145 0.1894 IL1B/NR3C2/MALT1/IL12B/TNF/TRIM44/TLR3/IL23A/TLR6 9 GO:0000470 maturation of LSU-rRNA 4/1036 21/18670 0.02648 0.2145 0.1894 ZNHIT3/ZNHIT6/RPL35/WDR12 4 GO:0006293 nucleotide-excision repair, preincision complex stabilization 4/1036 21/18670 0.02648 0.2145 0.1894 PARP1/RBX1/GTF2H3/RPA1 4 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion 4/1036 21/18670 0.02648 0.2145 0.1894 PARP1/RBX1/GTF2H3/RPA1 4 GO:0009081 branched-chain amino acid metabolic process 4/1036 21/18670 0.02648 0.2145 0.1894 DLD/BCKDHA/MCCC1/ACAT1 4 GO:0009083 branched-chain amino acid catabolic process 4/1036 21/18670 0.02648 0.2145 0.1894 DLD/BCKDHA/MCCC1/ACAT1 4 GO:0043984 histone H4-K16 acetylation 4/1036 21/18670 0.02648 0.2145 0.1894 AUTS2/KANSL2/KAT8/ATG5 4 GO:0048245 eosinophil chemotaxis 4/1036 21/18670 0.02648 0.2145 0.1894 CCL5/DAPK2/CCL11/CCL23 4 GO:0061003 positive regulation of dendritic spine morphogenesis 4/1036 21/18670 0.02648 0.2145 0.1894 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:1902884 positive regulation of response to oxidative stress 4/1036 21/18670 0.02648 0.2145 0.1894 SFPQ/TNF/TLR6/SOD1 4 GO:1901214 regulation of neuron death 26/1036 313/18670 0.0265 0.2145 0.1894 PARP1/NAE1/CCL5/IFNG/RASA1/KMO/BTG2/GCLC/FYN/CHGA/ERBB3/TNF/LANCL1/MSH2/LRP1/PIK3CA/RRAS2/HDAC4/GABRB2/TLR6/DAXX/UBB/SOD1/AP2B1/ADNP/XRCC2 26 GO:0009154 purine ribonucleotide catabolic process 5/1036 31/18670 0.02661 0.2145 0.1894 HINT1/PDE4B/PDE8A/NUDT9/ACAT1 5 GO:0033198 response to ATP 5/1036 31/18670 0.02661 0.2145 0.1894 IL1B/P2RX5/P2RX1/P2RX6/SOD1 5 GO:0090075 relaxation of muscle 5/1036 31/18670 0.02661 0.2145 0.1894 ATP2A2/CHGA/PDE4B/ATP1B1/SOD1 5 GO:0072593 reactive oxygen species metabolic process 24/1036 284/18670 0.0269 0.2165 0.1911 IFNG/TGFBR2/IL1B/PTX3/RORA/CAT/SOD3/SESN1/HP/FYN/TNF/NNT/SPHK2/HDAC4/TLR6/AKR1C3/PRDX6/PMAIP1/SOD1/NDUFS1/NDUFS4/KHSRP/BCR/ATG5 24 GO:0043401 steroid hormone mediated signaling pathway 17/1036 184/18670 0.02731 0.2192 0.1936 LBH/PARP1/TRIM68/NR3C2/RORA/NR2C1/CRY1/RWDD1/PHB2/NCOA3/RARA/GHRHR/KDM5D/DAXX/RNF4/NCOR1/ZBTB7A 17 GO:0006509 membrane protein ectodomain proteolysis 6/1036 42/18670 0.02732 0.2192 0.1936 IFNG/IL1B/PRKCQ/TNF/TIMP2/TIMP4 6 GO:0006757 ATP generation from ADP 12/1036 116/18670 0.02743 0.2198 0.1941 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 12 GO:0051983 regulation of chromosome segregation 11/1036 103/18670 0.02756 0.2205 0.1947 SFPQ/CDC23/ANAPC5/PSMG2/CSNK2A2/PUM1/NDC80/TNKS/RIOK2/FBXO5/ATRX 11 GO:0043900 regulation of multi-organism process 32/1036 405/18670 0.02839 0.2262 0.1998 OPTN/CCL5/IFNG/IL1B/C1QBP/PTX3/LAMP3/IL12B/PRF1/ZFP36/HTRA1/BIRC3/TNF/DDX60/ANKRD17/TRIM44/CXCR4/EXOC7/IL23A/PUM1/GLRA1/RSAD2/MAPK3/PABPC1/HDAC4/APOBEC3G/VPS37B/IL15/FCN1/PQBP1/PGLYRP4/GPATCH3 32 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 9/1036 78/18670 0.02841 0.2262 0.1998 DYRK2/HINT1/RPS7/MSH2/STK11/UBB/PMAIP1/RPL11/EDA2R 9 GO:1903313 positive regulation of mRNA metabolic process 9/1036 78/18670 0.02841 0.2262 0.1998 TRA2B/BTG2/ZFP36/HNRNPR/NUDT21/PUM1/PABPC1/PRDX6/KHSRP 9 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 16/1036 171/18670 0.02853 0.2262 0.1998 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/CYC1/NUP85/SPHK2/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 16 GO:0006997 nucleus organization 13/1036 130/18670 0.02853 0.2262 0.1998 NUP107/POLR1B/EMG1/PSME4/NUP205/SYNE1/USPL1/PARP11/VRK1/DYRK3/TMEM43/SERBP1/TOR1AIP1 13 GO:0050671 positive regulation of lymphocyte proliferation 13/1036 130/18670 0.02853 0.2262 0.1998 CD38/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/ANXA1/IL23A/GPR183/IL15/CD3E 13 GO:0002720 positive regulation of cytokine production involved in immune response 7/1036 54/18670 0.0289 0.2278 0.2012 IL6/IL1B/MALT1/DDX1/DDX21/RSAD2/MAPK3 7 GO:0002763 positive regulation of myeloid leukocyte differentiation 7/1036 54/18670 0.0289 0.2278 0.2012 IFNG/GNAS/IL12B/TNF/IL23A/LIF/HAX1 7 GO:0032210 regulation of telomere maintenance via telomerase 7/1036 54/18670 0.0289 0.2278 0.2012 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/TERF1 7 GO:0032655 regulation of interleukin-12 production 7/1036 54/18670 0.0289 0.2278 0.2012 SLAMF1/NFKB1/IFNG/C1QBP/IL12B/TLR3/IL23A 7 GO:1901607 alpha-amino acid biosynthetic process 8/1036 66/18670 0.02907 0.2288 0.202 SEPHS1/PLOD1/MTR/OTC/CBS/ASNSD1/AASDHPPT/SLC1A3 8 GO:0007254 JNK cascade 19/1036 214/18670 0.02946 0.2315 0.2044 AIDA/SLAMF1/IL1B/DACT1/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP4K5/UBA52/PTGER4/MAP4K2/TLR6/DAXX/UBB/ZMYND11/NCOR1/EDA2R 19 GO:0009132 nucleoside diphosphate metabolic process 15/1036 158/18670 0.0297 0.2331 0.2058 PGK1/NUP107/IFNG/CMPK1/NUP37/NUP205/NUP85/HDAC4/SUCLG1/PFKP/NUDT9/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0009145 purine nucleoside triphosphate biosynthetic process 16/1036 172/18670 0.0299 0.2338 0.2065 PARP1/PGK1/NUP107/IFNG/FLCN/NUP37/NUP205/CYC1/NUP85/SPHK2/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 16 GO:0042326 negative regulation of phosphorylation 36/1036 468/18670 0.02999 0.2338 0.2065 AIDA/RHOH/FKBP8/MYC/RANBP9/IFNG/ATG14/DUSP2/IL1B/FLCN/DACT1/NCK1/STK38/DYNLL1/CBLB/MICAL1/COX11/PTPN22/ATF3/NNT/TRIB2/CDK5RAP1/PEBP1/NPM1/PRKAR2B/GPD1L/LIF/HDAC4/DUSP21/HEG1/IGBP1/PSMD10/ZMYND11/NCOR1/PAQR3/IPO7 36 GO:0032946 positive regulation of mononuclear cell proliferation 13/1036 131/18670 0.03014 0.2338 0.2065 CD38/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/ANXA1/IL23A/GPR183/IL15/CD3E 13 GO:0009261 ribonucleotide catabolic process 5/1036 32/18670 0.03014 0.2338 0.2065 HINT1/PDE4B/PDE8A/NUDT9/ACAT1 5 GO:0035587 purinergic receptor signaling pathway 5/1036 32/18670 0.03014 0.2338 0.2065 GPR171/P2RX5/P2RX1/P2RX6/P2RY10 5 GO:0038128 ERBB2 signaling pathway 5/1036 32/18670 0.03014 0.2338 0.2065 SOS1/ERBB3/CPNE3/PIK3CA/PIK3R1 5 GO:0046685 response to arsenic-containing substance 5/1036 32/18670 0.03014 0.2338 0.2065 GCLC/ATF3/ZFAND1/DAXX/RNF4 5 GO:1901661 quinone metabolic process 5/1036 32/18670 0.03014 0.2338 0.2065 PDSS1/AKR7A2/AKR1B1/AKR1C3/COQ9 5 GO:0006775 fat-soluble vitamin metabolic process 6/1036 43/18670 0.03032 0.2341 0.2067 NFKB1/IFNG/IL1B/TNF/PIAS4/CYP4F12 6 GO:0050850 positive regulation of calcium-mediated signaling 6/1036 43/18670 0.03032 0.2341 0.2067 HINT1/TRAT1/P2RX5/ERBB3/TNF/CD3E 6 GO:1901985 positive regulation of protein acetylation 6/1036 43/18670 0.03032 0.2341 0.2067 AUTS2/BRD7/IL1B/MAPK3/LIF/SPHK2 6 GO:0006446 regulation of translational initiation 9/1036 79/18670 0.03054 0.2352 0.2077 CCL5/EIF4B/NCK1/TNF/MTIF2/PAIP1/DDX1/NPM1/EIF5 9 GO:0071260 cellular response to mechanical stimulus 9/1036 79/18670 0.03054 0.2352 0.2077 NFKB1/IL1B/GCLC/PIEZO2/TLR3/MAPK3/HDAC4/PTGER4/SLC38A2 9 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4/1036 22/18670 0.03099 0.2366 0.2089 EXOSC8/RRS1/RPS21/WDR12 4 GO:0033233 regulation of protein sumoylation 4/1036 22/18670 0.03099 0.2366 0.2089 TOLLIP/PIAS4/HDAC4/HMG20A 4 GO:0048305 immunoglobulin secretion 4/1036 22/18670 0.03099 0.2366 0.2089 IL6/POU2F2/TNF/XBP1 4 GO:0071359 cellular response to dsRNA 4/1036 22/18670 0.03099 0.2366 0.2089 NFKB1/TLR3/NPM1/PQBP1 4 GO:0072643 interferon-gamma secretion 4/1036 22/18670 0.03099 0.2366 0.2089 CD2/CD244/PTPN22/RASGRP1 4 GO:1904666 regulation of ubiquitin protein ligase activity 4/1036 22/18670 0.03099 0.2366 0.2089 RPS7/DNM1L/FBXO5/RPL11 4 GO:2000573 positive regulation of DNA biosynthetic process 8/1036 67/18670 0.03147 0.2399 0.2118 MYC/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1 8 GO:0006383 transcription by RNA polymerase III 7/1036 55/18670 0.03159 0.2401 0.212 GTF3C3/POLR3K/ICE1/POLR3C/TBP/ICE2/GTF3A 7 GO:0030518 intracellular steroid hormone receptor signaling pathway 13/1036 132/18670 0.0318 0.2401 0.212 LBH/PARP1/TRIM68/CRY1/RWDD1/PHB2/NCOA3/GHRHR/KDM5D/DAXX/RNF4/NCOR1/ZBTB7A 13 GO:0000054 ribosomal subunit export from nucleus 3/1036 13/18670 0.03208 0.2401 0.212 NPM1/RIOK2/RRS1 3 GO:0032823 regulation of natural killer cell differentiation 3/1036 13/18670 0.03208 0.2401 0.212 RASGRP1/IL15/PGLYRP4 3 GO:0033750 ribosome localization 3/1036 13/18670 0.03208 0.2401 0.212 NPM1/RIOK2/RRS1 3 GO:0035723 interleukin-15-mediated signaling pathway 3/1036 13/18670 0.03208 0.2401 0.212 IL2RB/IL15RA/IL15 3 GO:0035745 T-helper 2 cell cytokine production 3/1036 13/18670 0.03208 0.2401 0.212 IL6/TBX21/RSAD2 3 GO:0038007 netrin-activated signaling pathway 3/1036 13/18670 0.03208 0.2401 0.212 SIAH2/DSCAM/NTN1 3 GO:0046349 amino sugar biosynthetic process 3/1036 13/18670 0.03208 0.2401 0.212 GNE/UAP1L1/GFPT1 3 GO:0071350 cellular response to interleukin-15 3/1036 13/18670 0.03208 0.2401 0.212 IL2RB/IL15RA/IL15 3 GO:0090239 regulation of histone H4 acetylation 3/1036 13/18670 0.03208 0.2401 0.212 AUTS2/SPI1/ATG5 3 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 3/1036 13/18670 0.03208 0.2401 0.212 SLC35D1/SLC35A5/SLC35A1 3 GO:0098703 calcium ion import across plasma membrane 3/1036 13/18670 0.03208 0.2401 0.212 FYN/FAM155B/TRPM2 3 GO:0007204 positive regulation of cytosolic calcium ion concentration 26/1036 319/18670 0.03246 0.2426 0.2142 CD38/CXCL11/CCR3/P2RX5/GPR18/CLIC2/CXCR6/FYN/NTSR1/FAM155B/TRPM2/CXCR4/LRP1/LCK/PLCB3/CCKBR/JPH3/AVPR1B/PTGER4/LPAR6/MCOLN1/NMU/TRPM1/P2RY10/GRIN2D/ATG5 26 GO:0042866 pyruvate biosynthetic process 12/1036 119/18670 0.0326 0.2433 0.2149 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 12 GO:0006367 transcription initiation from RNA polymerase II promoter 17/1036 188/18670 0.03266 0.2434 0.215 NR3C2/RORA/GTF2A2/MED23/PSMC2/NR2C1/GTF2H3/CDK8/RARA/TBP/TAF5/CCNC/ZNF45/MED17/GTF2E1/TAF12/PSMC5 17 GO:0033045 regulation of sister chromatid segregation 9/1036 80/18670 0.03279 0.244 0.2155 SFPQ/CDC23/ANAPC5/PSMG2/NDC80/TNKS/RIOK2/FBXO5/ATRX 9 GO:0002286 T cell activation involved in immune response 11/1036 106/18670 0.03313 0.2459 0.2171 IL6/IFNG/MALT1/RORA/IL12B/ANXA1/TBX21/IL23A/RARA/PTGER4/GPR183 11 GO:0007041 lysosomal transport 11/1036 106/18670 0.03313 0.2459 0.2171 ATG14/NPC1/GPRASP1/LRP1/STX8/HMGXB4/CCDC91/TMEM106B/VPS51/EHD3/DENND3 11 GO:0003015 heart process 24/1036 290/18670 0.03327 0.2465 0.2177 CLIC2/MYL1/ATP2A2/FYN/CHGA/PDE4B/SCN10A/CXCR4/PPCS/DNM1L/SLC8A2/PIK3CA/GPD1L/ATP1B1/HDAC4/CHRM2/CACNB4/RANGRF/ATP2B2/EHD3/SOD1/KCNQ1/NMU/ATG5 24 GO:0043393 regulation of protein binding 19/1036 217/18670 0.03331 0.2465 0.2177 AIDA/DACT1/ITGA4/LDLRAP1/DERL1/IFIT2/PLCL1/CAPRIN2/TGFBR3/MAP2/LRP1/SMARCD3/MAPK3/HDAC4/RPL11/ADAM15/ADNP/CCL23/CRMP1 19 GO:0014002 astrocyte development 6/1036 44/18670 0.03351 0.2467 0.2178 IL6/IFNG/IL1B/TNF/LRP1/ROR1 6 GO:0060412 ventricular septum morphogenesis 6/1036 44/18670 0.03351 0.2467 0.2178 TGFBR2/ACVR1/TGFBR3/RBM15/CITED2/FZD2 6 GO:0071622 regulation of granulocyte chemotaxis 6/1036 44/18670 0.03351 0.2467 0.2178 CCL5/C1QBP/DAPK2/IL23A/MAPK3/LBP 6 GO:0090311 regulation of protein deacetylation 6/1036 44/18670 0.03351 0.2467 0.2178 IFNG/BEX4/FNTA/SPHK2/DYRK1A/ZNHIT1 6 GO:0002756 MyD88-independent toll-like receptor signaling pathway 5/1036 33/18670 0.03396 0.2479 0.2189 BIRC3/TLR3/UBA52/TLR6/UBB 5 GO:0006471 protein ADP-ribosylation 5/1036 33/18670 0.03396 0.2479 0.2189 PARP1/IFNG/PARP11/TNKS/ADNP 5 GO:0032633 interleukin-4 production 5/1036 33/18670 0.03396 0.2479 0.2189 PRKCQ/ITK/RARA/CD83/CD3E 5 GO:0046633 alpha-beta T cell proliferation 5/1036 33/18670 0.03396 0.2479 0.2189 TGFBR2/IL12B/IL23A/IL15/CD3E 5 GO:0051204 protein insertion into mitochondrial membrane 5/1036 33/18670 0.03396 0.2479 0.2189 MOAP1/GZMB/YWHAQ/OXA1L/PMAIP1 5 GO:0051955 regulation of amino acid transport 5/1036 33/18670 0.03396 0.2479 0.2189 ABAT/KMO/NTSR1/SV2A/TRH 5 GO:0033047 regulation of mitotic sister chromatid segregation 8/1036 68/18670 0.034 0.2479 0.2189 CDC23/ANAPC5/PSMG2/NDC80/TNKS/RIOK2/FBXO5/ATRX 8 GO:0031295 T cell costimulation 7/1036 56/18670 0.03444 0.2501 0.2208 ICOS/FYN/LCK/PIK3CA/CD3E/PIK3R1/EFNB3 7 GO:0032615 interleukin-12 production 7/1036 56/18670 0.03444 0.2501 0.2208 SLAMF1/NFKB1/IFNG/C1QBP/IL12B/TLR3/IL23A 7 GO:0098586 cellular response to virus 7/1036 56/18670 0.03444 0.2501 0.2208 LGALS8/C1QBP/BIRC3/DDX60/ANKRD17/PUM1/GPATCH3 7 GO:0001909 leukocyte mediated cytotoxicity 11/1036 107/18670 0.03515 0.2549 0.2251 SH2D1A/CTSC/IL12B/PRF1/GZMB/CD1A/RASGRP1/EMP2/IL23A/ELANE/CTSG 11 GO:0016569 covalent chromatin modification 36/1036 474/18670 0.03524 0.2552 0.2253 AUTS2/BRD7/HAT1/CTR9/IL1B/SFPQ/FLCN/SKP1/FBL/AURKC/SUPT7L/TRIM37/SART3/USP16/YEATS2/NCOA3/MAPK3/LIF/SPHK2/HDAC4/VRK1/BRD1/KDM5C/SPI1/KDM5D/TAF5/WAC/CPA4/KANSL2/ZNHIT1/ATRX/TAF12/SATB1/CBX8/KAT8/ATG5 36 GO:0014065 phosphatidylinositol 3-kinase signaling 14/1036 148/18670 0.03579 0.2562 0.2263 CCL5/C1QBP/PPP1R16B/PPP2R5C/CAT/FYN/ERBB3/TNF/RASGRP1/PIK3CA/MAPK3/PIK3C2A/HAX1/PIK3R1 14 GO:0006297 nucleotide-excision repair, DNA gap filling 4/1036 23/18670 0.03591 0.2562 0.2263 PCNA/UBA52/UBB/RPA1 4 GO:0009067 aspartate family amino acid biosynthetic process 4/1036 23/18670 0.03591 0.2562 0.2263 PLOD1/MTR/ASNSD1/AASDHPPT 4 GO:0009226 nucleotide-sugar biosynthetic process 4/1036 23/18670 0.03591 0.2562 0.2263 SLC35D1/UGP2/UAP1L1/GFPT1 4 GO:0032373 positive regulation of sterol transport 4/1036 23/18670 0.03591 0.2562 0.2263 LDLRAP1/LRP1/SCP2/PON1 4 GO:0032376 positive regulation of cholesterol transport 4/1036 23/18670 0.03591 0.2562 0.2263 LDLRAP1/LRP1/SCP2/PON1 4 GO:0032717 negative regulation of interleukin-8 production 4/1036 23/18670 0.03591 0.2562 0.2263 PTPN22/ANXA1/ELANE/TLR6 4 GO:0034123 positive regulation of toll-like receptor signaling pathway 4/1036 23/18670 0.03591 0.2562 0.2263 PTPN22/TLR3/RSAD2/LBP 4 GO:0043576 regulation of respiratory gaseous exchange 4/1036 23/18670 0.03591 0.2562 0.2263 PASK/NTSR1/GLRA1/TLX3 4 GO:0070841 inclusion body assembly 4/1036 23/18670 0.03591 0.2562 0.2263 SACS/TRIM37/DNAJB1/PSMC5 4 GO:0090140 regulation of mitochondrial fission 4/1036 23/18670 0.03591 0.2562 0.2263 DDHD2/TMEM135/DNM1L/MFF 4 GO:0002833 positive regulation of response to biotic stimulus 6/1036 45/18670 0.03692 0.2627 0.2319 OPTN/IL12B/DDX60/ANKRD17/PUM1/MAPK3 6 GO:0032309 icosanoid secretion 6/1036 45/18670 0.03692 0.2627 0.2319 IL1B/NTSR1/ANXA1/ABCC4/PLA2G3/CYP4A11 6 GO:0032103 positive regulation of response to external stimulus 26/1036 323/18670 0.03696 0.2627 0.2319 OPTN/CCL5/IL6/IL1B/C1QBP/CTSC/IL12B/TNF/F12/DDX60/ANKRD17/CXCR4/DAPK2/ARTN/LRP1/TLR3/IL23A/PUM1/MAPK3/PTGER4/TLR6/DSCAM/IL15/FGF18/IL17B/LBP 26 GO:1903532 positive regulation of secretion by cell 31/1036 399/18670 0.03717 0.2635 0.2327 CD38/ABAT/IL1A/IL6/IFNG/CD2/IL1B/OXCT1/KMO/DYNLL1/CD244/NTSR1/TNF/PTPN22/CD2AP/LRP1/RASGRP1/DNM1L/XBP1/RAB9A/MBP/TRH/MAPK3/SPHK2/AIMP1/PTGER4/CLASP1/GHRHR/FCN1/NMU/SEC24A 31 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 13/1036 135/18670 0.03719 0.2635 0.2327 RCHY1/CTR9/MALT1/TOLLIP/DERL1/SART3/CRY1/BIRC3/PTPN22/PIAS4/HDAC4/PSMD10/UBB 13 GO:0031294 lymphocyte costimulation 7/1036 57/18670 0.03746 0.2635 0.2327 ICOS/FYN/LCK/PIK3CA/CD3E/PIK3R1/EFNB3 7 GO:0032642 regulation of chemokine production 9/1036 82/18670 0.03761 0.2635 0.2327 IL6/IFNG/IL1B/TNF/LRP1/TLR3/MBP/ELANE/LBP 9 GO:0034502 protein localization to chromosome 9/1036 82/18670 0.03761 0.2635 0.2327 CCT7/CCT2/MSH2/ATR/NDC80/TNKS/ATRX/RPA1/TERF1 9 GO:1905954 positive regulation of lipid localization 9/1036 82/18670 0.03761 0.2635 0.2327 NFKB1/IL1B/LDLRAP1/NTSR1/ATP8A1/LRP1/SCP2/PON1/CYP4A11 9 GO:0032640 tumor necrosis factor production 15/1036 163/18670 0.03766 0.2635 0.2327 SLAMF1/IFNG/CD2/GPR18/IL12B/ZFP36/PTPN22/RASGRP1/TLR3/IL23A/RARA/SPHK2/PIK3R1/UBE2J1/LBP 15 GO:0051170 import into nucleus 15/1036 163/18670 0.03766 0.2635 0.2327 NUP107/IFNG/BACH2/SNRPD1/CBLB/RANBP6/PHB2/NUP85/CSE1L/SNRPF/SNRPD2/PIK3R1/SIX2/NUP214/IPO7 15 GO:0031330 negative regulation of cellular catabolic process 22/1036 264/18670 0.03768 0.2635 0.2327 USP25/LAMP3/HNRNPA0/NPC1/ZFP36/HP/SCFD1/HERC1/PTPN22/RPS7/PAIP1/CSNK2A2/ELAVL1/PIK3CA/PABPC1/TIMP2/HDAC4/TIMP4/WAC/RPL11/UBE2J1/FEZ1 22 GO:0042116 macrophage activation 10/1036 95/18670 0.03772 0.2635 0.2327 IL6/IFNG/RORA/CTSC/CRTC3/TNF/TLR3/CST7/TLR6/LBP 10 GO:0050810 regulation of steroid biosynthetic process 10/1036 95/18670 0.03772 0.2635 0.2327 NFKB1/IFNG/IL1B/IDI1/INSIG1/TNF/NFYB/AKR1C3/SC5D/SOD1 10 GO:0051196 regulation of coenzyme metabolic process 10/1036 95/18670 0.03772 0.2635 0.2327 NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/NCOR1/NUP160/NUP214/ZBTB7A 10 GO:1903076 regulation of protein localization to plasma membrane 10/1036 95/18670 0.03772 0.2635 0.2327 IFNG/PRKCH/LDLRAP1/TNF/LRP1/STX8/ANXA13/RANGRF/ACSL3/PIK3R1 10 GO:0010574 regulation of vascular endothelial growth factor production 5/1036 34/18670 0.03806 0.2648 0.2339 IL1A/IL6/IL1B/RORA/SULF1 5 GO:0033120 positive regulation of RNA splicing 5/1036 34/18670 0.03806 0.2648 0.2339 TRA2B/PRDX6/DYRK1A/SETX/PIK3R1 5 GO:0070050 neuron cellular homeostasis 5/1036 34/18670 0.03806 0.2648 0.2339 NELL2/IL6/P2RX1/CALB2/ATP2B2 5 GO:0043414 macromolecule methylation 25/1036 309/18670 0.03817 0.2653 0.2343 PARP1/MYC/AUTS2/CTR9/TFB2M/FBL/GNAS/BTG2/EMG1/TARBP1/TRMT61B/MTO1/PIK3CA/RBM15/TRMT5/TRMT112/PCMTD2/RBM15B/SPI1/DIMT1/ATRX/GSPT1/METTL4/SATB1/CBLL1 25 GO:0048545 response to steroid hormone 30/1036 385/18670 0.03856 0.2676 0.2363 LBH/CD38/PCNA/PARP1/IL6/TGFBR2/TRIM68/NR3C2/RORA/HSD11B2/NPC1/ZFP36/NR2C1/CRY1/TNF/RWDD1/ANXA1/PHB2/NCOA3/RARA/TRH/RBBP7/AKR1C3/GHRHR/KDM5D/DAXX/RNF4/NCOR1/CATSPERG/ZBTB7A 30 GO:0071383 cellular response to steroid hormone stimulus 21/1036 250/18670 0.03868 0.2678 0.2364 LBH/PARP1/TRIM68/NR3C2/RORA/NPC1/ZFP36/NR2C1/CRY1/RWDD1/ANXA1/PHB2/NCOA3/RARA/AKR1C3/GHRHR/KDM5D/DAXX/RNF4/NCOR1/ZBTB7A 21 GO:0002523 leukocyte migration involved in inflammatory response 3/1036 14/18670 0.03918 0.2678 0.2364 ELANE/SLAMF8/LBP 3 GO:0015780 nucleotide-sugar transmembrane transport 3/1036 14/18670 0.03918 0.2678 0.2364 SLC35D1/SLC35A5/SLC35A1 3 GO:0045346 regulation of MHC class II biosynthetic process 3/1036 14/18670 0.03918 0.2678 0.2364 IFNG/XBP1/SPI1 3 GO:0051712 positive regulation of killing of cells of other organism 3/1036 14/18670 0.03918 0.2678 0.2364 IFNG/PRF1/PGLYRP4 3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 3/1036 14/18670 0.03918 0.2678 0.2364 BTG2/ZFP36/PABPC1 3 GO:0070672 response to interleukin-15 3/1036 14/18670 0.03918 0.2678 0.2364 IL2RB/IL15RA/IL15 3 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 3/1036 14/18670 0.03918 0.2678 0.2364 NPM1/RIOK2/RRS1 3 GO:0072567 chemokine (C-X-C motif) ligand 2 production 3/1036 14/18670 0.03918 0.2678 0.2364 TNF/LRP1/MBP 3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/1036 14/18670 0.03918 0.2678 0.2364 ATF3/BMPR1B/PMAIP1 3 GO:1902656 calcium ion import into cytosol 3/1036 14/18670 0.03918 0.2678 0.2364 FYN/FAM155B/TRPM2 3 GO:1904814 regulation of protein localization to chromosome, telomeric region 3/1036 14/18670 0.03918 0.2678 0.2364 CCT7/CCT2/TERF1 3 GO:0006289 nucleotide-excision repair 11/1036 109/18670 0.03945 0.269 0.2375 PCNA/PARP1/TCEA1/COPS4/RBX1/GTF2H3/UBA52/HMGN1/SLC30A9/UBB/RPA1 11 GO:0007004 telomere maintenance via telomerase 8/1036 70/18670 0.03946 0.269 0.2375 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/RPA1/TERF1 8 GO:0008652 cellular amino acid biosynthetic process 9/1036 83/18670 0.0402 0.2737 0.2417 ABAT/SEPHS1/PLOD1/MTR/OTC/CBS/ASNSD1/AASDHPPT/SLC1A3 9 GO:0006399 tRNA metabolic process 17/1036 193/18670 0.0404 0.2743 0.2422 IARS2/GTF3C3/SEPHS1/PPA1/TARBP1/TRMT61B/EXOSC8/POLR3K/DDX1/EEF1E1/CDK5RAP1/THUMPD1/MTO1/TRMT5/AIMP1/TRMT112/TPRKB 17 GO:0044706 multi-multicellular organism process 19/1036 222/18670 0.04054 0.2743 0.2422 CD38/TGFBR2/IL1B/C1QBP/UBE2Q1/HSD11B2/POLR1B/P2RX1/RECK/EMP2/RARA/MAPK3/LIF/SPHK2/AKR1B1/RPL29/SOD1/SLC38A2/TMED2 19 GO:0009116 nucleoside metabolic process 12/1036 123/18670 0.04054 0.2743 0.2422 PRPS2/DCK/DERA/CMPK1/ENPP4/PRPS1/MFN1/UCKL1/AHCY/APOBEC3G/PRPSAP2/APRT 12 GO:0030490 maturation of SSU-rRNA 6/1036 46/18670 0.04055 0.2743 0.2422 UTP3/NOL11/RIOK2/RRS1/RPS21/PWP2 6 GO:0043330 response to exogenous dsRNA 6/1036 46/18670 0.04055 0.2743 0.2422 DDX1/DDX21/TLR3/MAPK3/RFTN1/PQBP1 6 GO:0031663 lipopolysaccharide-mediated signaling pathway 7/1036 58/18670 0.04064 0.2746 0.2425 CCL5/IL1B/MALT1/TNF/PTPN22/MAPK3/LBP 7 GO:0060048 cardiac muscle contraction 13/1036 137/18670 0.04113 0.277 0.2446 CLIC2/MYL1/ATP2A2/CHGA/PDE4B/SCN10A/CXCR4/PIK3CA/GPD1L/ATP1B1/HDAC4/EHD3/KCNQ1 13 GO:0009110 vitamin biosynthetic process 4/1036 24/18670 0.04126 0.277 0.2446 NFKB1/IFNG/IL1B/TNF 4 GO:0031579 membrane raft organization 4/1036 24/18670 0.04126 0.277 0.2446 CD2/NPC1/EMP2/RFTN1 4 GO:0033119 negative regulation of RNA splicing 4/1036 24/18670 0.04126 0.277 0.2446 C1QBP/SRSF10/HNRNPA2B1/DYRK1A 4 GO:0090023 positive regulation of neutrophil chemotaxis 4/1036 24/18670 0.04126 0.277 0.2446 C1QBP/DAPK2/IL23A/LBP 4 GO:0000070 mitotic sister chromatid segregation 14/1036 151/18670 0.04133 0.2771 0.2447 AURKC/CDC23/ANAPC5/ZWINT/PSMG2/HIRA/NDC80/TNKS/RIOK2/FBXO5/RRS1/ATRX/PRC1/SMC2 14 GO:0048732 gland development 33/1036 434/18670 0.04178 0.2798 0.2471 LBH/PCNA/ARID5B/TGFBR2/CAPN1/TNF/TGFBR3/LHX3/ANXA1/CSNK2A2/PHB2/HRH2/BCL11B/XBP1/SULF1/QDPR/USF2/RARA/PIK3CA/CCKBR/MAPK3/OTC/STK11/CCL11/CSN2/CITED2/GHRHR/SOD1/NTN1/APRT/KRT76/ACAT1/IGSF3 33 GO:0000266 mitochondrial fission 5/1036 35/18670 0.04245 0.2822 0.2492 DDHD2/SLC25A46/TMEM135/DNM1L/MFF 5 GO:0006369 termination of RNA polymerase II transcription 5/1036 35/18670 0.04245 0.2822 0.2492 PCF11/NUDT21/CSTF2T/SNRPF/SETX 5 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 5/1036 35/18670 0.04245 0.2822 0.2492 LBH/CRY1/PHB2/NCOR1/ZBTB7A 5 GO:0042092 type 2 immune response 5/1036 35/18670 0.04245 0.2822 0.2492 IL6/ANXA1/TBX21/RARA/RSAD2 5 GO:0060251 regulation of glial cell proliferation 5/1036 35/18670 0.04245 0.2822 0.2492 IL6/IL1B/PRKCH/PPP1CC/TNF 5 GO:0097484 dendrite extension 5/1036 35/18670 0.04245 0.2822 0.2492 AUTS2/CPNE6/CXCR4/CYFIP2/STK11 5 GO:2001022 positive regulation of response to DNA damage stimulus 10/1036 97/18670 0.04259 0.2825 0.2495 PCNA/PARP1/MYC/BCLAF1/WAS/EEF1E1/ATR/PIAS4/PMAIP1/CBX8 10 GO:0008637 apoptotic mitochondrial changes 12/1036 124/18670 0.04272 0.2825 0.2495 MOAP1/SLC25A5/IFIT2/GZMB/GCLC/YWHAQ/DNM1L/PSMD10/PMAIP1/MFF/NDUFS1/SLC35F6 12 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 12/1036 124/18670 0.04272 0.2825 0.2495 CCL5/PPP1R16B/PPP2R5C/CAT/FYN/ERBB3/TNF/RASGRP1/PIK3CA/MAPK3/HAX1/PIK3R1 12 GO:0019218 regulation of steroid metabolic process 12/1036 124/18670 0.04272 0.2825 0.2495 NFKB1/IFNG/IL1B/IDI1/RORA/INSIG1/LDLRAP1/TNF/NFYB/AKR1C3/SC5D/SOD1 12 GO:0072330 monocarboxylic acid biosynthetic process 27/1036 343/18670 0.04301 0.2841 0.2509 ABAT/ABCD3/PGK1/NUP107/IFNG/IL1B/NUP37/CHST12/INSIG1/KMO/NUP205/ANXA1/XBP1/NUP85/SCP2/HDAC4/CH25H/CYP2C9/AKR1C3/PFKP/ASNSD1/ACSL3/NCOR1/NUP160/NUP214/SLC1A3/ZBTB7A 27 GO:0009135 purine nucleoside diphosphate metabolic process 13/1036 138/18670 0.0432 0.2847 0.2514 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NUDT9/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0009179 purine ribonucleoside diphosphate metabolic process 13/1036 138/18670 0.0432 0.2847 0.2514 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NUDT9/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0015711 organic anion transport 36/1036 482/18670 0.0433 0.285 0.2516 FOLR3/ABAT/ABCD3/ABCB1/SLC35D1/IL1B/SLC25A32/CETP/KMO/SLC25A5/SLC38A1/SLC35A5/NTSR1/SV2A/ANXA1/ATP8A1/SLC7A5/SLC35A1/STARD7/TRH/SLC10A2/SLC22A13/SCP2/ABCC4/SLC16A6/SLC22A7/CA7/ACSL3/RHAG/PLA2G3/NCOR1/SLC38A2/SLC16A5/CA9/CYP4A11/SLC1A3 36 GO:0010565 regulation of cellular ketone metabolic process 16/1036 181/18670 0.04452 0.2923 0.2581 IL1B/PSMA2/INSIG1/ODC1/PSMA5/PSMD14/PSMA1/PSMC2/PSME4/ANXA1/PSMD12/PSMB1/AKR1C3/PSMD10/PSMC5/PSMA3 16 GO:0048015 phosphatidylinositol-mediated signaling 16/1036 181/18670 0.04452 0.2923 0.2581 CCL5/C1QBP/PPP1R16B/PPP2R5C/CAT/FYN/ERBB3/TNF/RASGRP1/PLCB3/PIK3CA/MAPK3/KCNH1/PIK3C2A/HAX1/PIK3R1 16 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 10/1036 98/18670 0.04518 0.2962 0.2616 HLA-DRB4/KIF2A/CTSD/HLA-DQB1/DYNLL1/HLA-DOB/KIFAP3/AP2B1/DCTN6/SEC24A 10 GO:0006261 DNA-dependent DNA replication 14/1036 153/18670 0.04534 0.2963 0.2616 PCNA/ORC3/ORC2/GMNN/CDK2AP1/FBXO5/ORC4/ATRX/RPA1/TERF1/DONSON/CDC7/MCM6/POLQ 14 GO:0045807 positive regulation of endocytosis 14/1036 153/18670 0.04534 0.2963 0.2616 IFNG/IL2RB/IL1B/PTX3/LDLRAP1/TNF/LRP1/DNM1L/IL15RA/IL15/SOD1/AP2B1/BCR/CBLL1 14 GO:0070665 positive regulation of leukocyte proliferation 13/1036 139/18670 0.04535 0.2963 0.2616 CD38/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/ANXA1/IL23A/GPR183/IL15/CD3E 13 GO:0006694 steroid biosynthetic process 17/1036 196/18670 0.04563 0.297 0.2623 NFKB1/IFNG/IL1B/IDI1/MSMO1/HSD11B2/INSIG1/TNF/FDX1/NFYB/SCP2/CH25H/AKR1B1/AKR1C3/SC5D/SOD1/CNBP 17 GO:0051348 negative regulation of transferase activity 23/1036 285/18670 0.04638 0.297 0.2623 AIDA/RHOH/IFNG/DUSP2/IL1B/NCK1/STK38/CBLB/ZFP36/COX11/PTPN22/RPS7/TRIB2/CDK5RAP1/NPM1/PRKAR2B/DUSP21/FBXO5/HEG1/RPL11/PAQR3/TERF1/IPO7 23 GO:0010821 regulation of mitochondrion organization 16/1036 182/18670 0.04641 0.297 0.2623 OPTN/DDHD2/FLCN/MOAP1/SLC25A5/GZMB/TMEM135/CSNK2A2/YWHAQ/DNM1L/PSMD10/VAT1/PMAIP1/HAX1/MFF/SLC35F6 16 GO:1990748 cellular detoxification 11/1036 112/18670 0.04657 0.297 0.2623 CAT/CLIC2/SOD3/SESN1/HP/TNF/NNT/GPX7/PRDX6/SOD1/IPCEF1 11 GO:0031331 positive regulation of cellular catabolic process 28/1036 361/18670 0.04662 0.297 0.2623 OPTN/IL6/IFNG/RCHY1/IL1B/FLCN/DACT1/CTSC/SESN1/BTG2/ZFP36/PSMC2/GCLC/TNF/RBX1/NNT/TRIB2/LRP1/HNRNPR/EDEM1/PUM1/MAPK3/PABPC1/FYCO1/STK11/PSMD10/WAC/KHSRP 28 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 3/1036 15/18670 0.04701 0.297 0.2623 UQCRB/CYCS/CYC1 3 GO:0032352 positive regulation of hormone metabolic process 3/1036 15/18670 0.04701 0.297 0.2623 IFNG/IL1B/TNF 3 GO:0032988 ribonucleoprotein complex disassembly 3/1036 15/18670 0.04701 0.297 0.2623 ZFAND1/MTIF2/DYRK3 3 GO:0042976 activation of Janus kinase activity 3/1036 15/18670 0.04701 0.297 0.2623 CCL5/IL12B/IL23A 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 3/1036 15/18670 0.04701 0.297 0.2623 EEF1E1/ATR/PMAIP1 3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 3/1036 15/18670 0.04701 0.297 0.2623 DYRK3/PSMD10/DYRK1A 3 GO:0043650 dicarboxylic acid biosynthetic process 3/1036 15/18670 0.04701 0.297 0.2623 KMO/KYNU/SLC1A3 3 GO:0045342 MHC class II biosynthetic process 3/1036 15/18670 0.04701 0.297 0.2623 IFNG/XBP1/SPI1 3 GO:0045410 positive regulation of interleukin-6 biosynthetic process 3/1036 15/18670 0.04701 0.297 0.2623 IL1B/TNF/TLR6 3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis 3/1036 15/18670 0.04701 0.297 0.2623 IFNG/IL1B/TNF 3 GO:0090141 positive regulation of mitochondrial fission 3/1036 15/18670 0.04701 0.297 0.2623 DDHD2/DNM1L/MFF 3 GO:0090197 positive regulation of chemokine secretion 3/1036 15/18670 0.04701 0.297 0.2623 TNF/LRP1/MBP 3 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 3/1036 15/18670 0.04701 0.297 0.2623 CCT7/CCT2/SHQ1 3 GO:2000484 positive regulation of interleukin-8 secretion 3/1036 15/18670 0.04701 0.297 0.2623 CD2/CD244/FCN1 3 GO:0071706 tumor necrosis factor superfamily cytokine production 15/1036 168/18670 0.04704 0.297 0.2623 SLAMF1/IFNG/CD2/GPR18/IL12B/ZFP36/PTPN22/RASGRP1/TLR3/IL23A/RARA/SPHK2/PIK3R1/UBE2J1/LBP 15 GO:1990138 neuron projection extension 15/1036 168/18670 0.04704 0.297 0.2623 AUTS2/ITGA4/ARHGAP4/CPNE6/CXCR4/MAP2/LRP1/SEMA4G/CYFIP2/SEMA3G/STK11/DBN1/DSCAM/NTN1/ADNP 15 GO:0002507 tolerance induction 4/1036 25/18670 0.04704 0.297 0.2623 TGFBR2/ICOS/CD3E/CLC 4 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 4/1036 25/18670 0.04704 0.297 0.2623 HSD11B2/EMP2/CYP4A11/CYP4F12 4 GO:0034110 regulation of homotypic cell-cell adhesion 4/1036 25/18670 0.04704 0.297 0.2623 ABAT/CCL5/PRKCQ/CD9 4 GO:0070129 regulation of mitochondrial translation 4/1036 25/18670 0.04704 0.297 0.2623 C1QBP/FASTKD3/NGRN/CDK5RAP1 4 GO:2000104 negative regulation of DNA-dependent DNA replication 4/1036 25/18670 0.04704 0.297 0.2623 GMNN/FBXO5/TERF1/DONSON 4 GO:0003091 renal water homeostasis 5/1036 36/18670 0.04713 0.297 0.2623 PRKACB/PRKAR2B/AKR1B1/CYP4A11/CYP4F12 5 GO:0006361 transcription initiation from RNA polymerase I promoter 5/1036 36/18670 0.04713 0.297 0.2623 POLR1B/GTF2H3/MAPK3/TBP/TAF1C 5 GO:0010573 vascular endothelial growth factor production 5/1036 36/18670 0.04713 0.297 0.2623 IL1A/IL6/IL1B/RORA/SULF1 5 GO:0033762 response to glucagon 5/1036 36/18670 0.04713 0.297 0.2623 PRKACB/CRY1/CYC1/QDPR/PRKAR2B 5 GO:0010952 positive regulation of peptidase activity 17/1036 197/18670 0.04748 0.2987 0.2638 MYC/MALT1/CTSD/PSMD14/P2RX1/CYCS/FYN/TNF/PSME4/CYFIP2/LCK/PCOLCE/MBP/HSPE1/MAPK3/PMAIP1/RCN3 17 GO:0043966 histone H3 acetylation 7/1036 60/18670 0.04753 0.2987 0.2638 SUPT7L/YEATS2/LIF/SPHK2/BRD1/SPI1/TAF12 7 GO:0009185 ribonucleoside diphosphate metabolic process 13/1036 140/18670 0.04757 0.2987 0.2638 PGK1/NUP107/IFNG/NUP37/NUP205/NUP85/HDAC4/PFKP/NUDT9/NCOR1/NUP160/NUP214/ZBTB7A 13 GO:0002762 negative regulation of myeloid leukocyte differentiation 6/1036 48/18670 0.04845 0.3028 0.2674 MYC/TLR3/RARA/LILRB3/LILRB4/PIK3R1 6 GO:0043628 ncRNA 3'-end processing 6/1036 48/18670 0.04845 0.3028 0.2674 FBL/INTS12/INTS8/EXOSC8/POLR3K/RPS21 6 GO:0061014 positive regulation of mRNA catabolic process 6/1036 48/18670 0.04845 0.3028 0.2674 BTG2/ZFP36/HNRNPR/PUM1/PABPC1/KHSRP 6 GO:0072604 interleukin-6 secretion 6/1036 48/18670 0.04845 0.3028 0.2674 IL1B/TNF/PTPN22/XBP1/MBP/SPHK2 6 GO:0006400 tRNA modification 9/1036 86/18670 0.04867 0.3039 0.2683 SEPHS1/TARBP1/TRMT61B/CDK5RAP1/THUMPD1/MTO1/TRMT5/TRMT112/TPRKB 9 GO:0060964 regulation of gene silencing by miRNA 11/1036 113/18670 0.04913 0.3064 0.2705 NUP107/NUP37/ZFP36/NUP205/ELAVL1/PUM1/NUP85/NCOR1/NUP160/NUP214/FXR1 11 GO:0090305 nucleic acid phosphodiester bond hydrolysis 24/1036 302/18670 0.04933 0.3072 0.2713 DROSHA/PCNA/PARP1/IL6/REXO2/DCP1A/PPP1R8/ZFP36/RBX1/PCF11/GTF2H3/EXOSC8/POLR3K/DDX1/NUDT21/UBA52/CSTF2T/ENDOD1/RRS1/UBB/RPS21/RPA1/PGAP1/RNASE1 24 GO:0048863 stem cell differentiation 21/1036 257/18670 0.04944 0.3076 0.2716 LBH/PSMA2/HSPA9/PSMA5/PSMD14/PSMA1/PSMC2/ACVR1/PSME4/PSMD12/SEMA4G/NUDT21/PUM1/MAPK3/LIF/SEMA3G/PSMB1/SOX21/PSMD10/PSMC5/PSMA3 21 GO:0032368 regulation of lipid transport 12/1036 127/18670 0.04974 0.3091 0.2729 NFKB1/IL1B/CETP/LDLRAP1/NTSR1/CRY1/ATP8A1/LRP1/SCP2/PON1/NCOR1/CYP4A11 12 GO:0009411 response to UV 13/1036 141/18670 0.04986 0.3095 0.2733 PCNA/PARP1/MYC/CAT/IL12B/USP1/MSH2/ATR/NPM1/HMGN1/ELANE/STK11/PIK3R1 13 GO:0015849 organic acid transport 26/1036 333/18670 0.05024 0.3105 0.2741 FOLR3/ABAT/ABCD3/SLC35D1/IL1B/SLC25A32/KMO/SLC38A1/SLC35A5/NTSR1/SV2A/ANXA1/SLC7A5/SLC35A1/TRH/SLC10A2/SLC22A13/ABCC4/SLC16A6/ACSL3/PLA2G3/NCOR1/SLC38A2/SLC16A5/CYP4A11/SLC1A3 26 GO:0032147 activation of protein kinase activity 26/1036 333/18670 0.05024 0.3105 0.2741 CCL5/TGFBR2/IL1B/MALT1/PRKACB/IL12B/TNF/CXCR4/EMP2/TLR3/MAP3K19/IL23A/MAP4K5/PRKAR2B/PIK3CA/MAPK3/UBA52/GPRC5C/STK11/MAP4K2/TLR6/DAXX/UBB/SOD1/ADNP/STRADA 26 GO:0046942 carboxylic acid transport 26/1036 333/18670 0.05024 0.3105 0.2741 FOLR3/ABAT/ABCD3/SLC35D1/IL1B/SLC25A32/KMO/SLC38A1/SLC35A5/NTSR1/SV2A/ANXA1/SLC7A5/SLC35A1/TRH/SLC10A2/SLC22A13/ABCC4/SLC16A6/ACSL3/PLA2G3/NCOR1/SLC38A2/SLC16A5/CYP4A11/SLC1A3 26 GO:0034728 nucleosome organization 16/1036 184/18670 0.05037 0.3105 0.2741 ITGB3BP/HAT1/ACTR6/RBBP4/SART3/HIRA/PSME4/NAP1L1/SMARCD3/NPM1/TSPY1/RBBP7/DAXX/ZNHIT1/ATRX/SMARCA5 16 GO:0042098 T cell proliferation 16/1036 184/18670 0.05037 0.3105 0.2741 SOS1/CCL5/IL6/TGFBR2/IL1B/MALT1/NCK1/PRKCQ/IL12B/FYN/ANXA1/IL23A/IL15/CD3E/SATB1/CLC 16 GO:0048017 inositol lipid-mediated signaling 16/1036 184/18670 0.05037 0.3105 0.2741 CCL5/C1QBP/PPP1R16B/PPP2R5C/CAT/FYN/ERBB3/TNF/RASGRP1/PLCB3/PIK3CA/MAPK3/KCNH1/PIK3C2A/HAX1/PIK3R1 16 GO:0072511 divalent inorganic cation transport 36/1036 489/18670 0.05142 0.3166 0.2796 CXCL11/CCL5/IFNG/P2RX5/CLIC2/ATP2A2/P2RX1/FYN/ORAI3/NTSR1/PDE4B/FAM155B/TRPM2/CXCR4/PHB2/DNM1L/BEST1/LCK/SLC8A2/PLCB3/ATP1B1/SPHK2/SLC30A9/JPH3/CACNB4/CSN2/ATP2B2/TSPAN13/TRPM6/EHD3/MCOLN1/TCN2/TRPM1/SLC39A6/GRIN2D/ATG5 36 GO:0051084 'de novo' posttranslational protein folding 5/1036 37/18670 0.05211 0.3202 0.2827 HSPA9/CCT2/DNAJB1/HSPE1/HSPA14 5 GO:0007030 Golgi organization 13/1036 142/18670 0.05223 0.3202 0.2827 OPTN/GORASP2/SYNE1/ARHGEF7/MAPK3/GOLGA8N/KIFC3/VRK1/GOLGA8A/CLASP1/VPS51/EHD3/TMED2 13 GO:0007034 vacuolar transport 13/1036 142/18670 0.05223 0.3202 0.2827 ATG14/NPC1/GPRASP1/LEPROTL1/LRP1/STX8/HMGXB4/CCDC91/TMEM106B/VPS51/VPS37B/EHD3/DENND3 13 GO:0002687 positive regulation of leukocyte migration 12/1036 128/18670 0.05224 0.3202 0.2827 CCL5/IL6/C1QBP/MADCAM1/ITGA4/TNF/DAPK2/IL23A/MAPK3/ELANE/CD99/LBP 12 GO:0046328 regulation of JNK cascade 16/1036 185/18670 0.05243 0.3209 0.2834 AIDA/SLAMF1/IL1B/DACT1/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP4K5/MAP4K2/TLR6/DAXX/ZMYND11/NCOR1/EDA2R 16 GO:0001913 T cell mediated cytotoxicity 6/1036 49/18670 0.05273 0.3213 0.2837 CTSC/IL12B/PRF1/CD1A/EMP2/IL23A 6 GO:0003254 regulation of membrane depolarization 6/1036 49/18670 0.05273 0.3213 0.2837 PARP1/GCLC/NTSR1/SCN10A/GPD1L/RANGRF 6 GO:0071715 icosanoid transport 6/1036 49/18670 0.05273 0.3213 0.2837 IL1B/NTSR1/ANXA1/ABCC4/PLA2G3/CYP4A11 6 GO:1901571 fatty acid derivative transport 6/1036 49/18670 0.05273 0.3213 0.2837 IL1B/NTSR1/ANXA1/ABCC4/PLA2G3/CYP4A11 6 GO:0002360 T cell lineage commitment 4/1036 26/18670 0.05324 0.3226 0.2849 IL6/IL12B/TBX21/IL23A 4 GO:0007020 microtubule nucleation 4/1036 26/18670 0.05324 0.3226 0.2849 RANBP9/TUBGCP2/RANGRF/CLASP1 4 GO:0034114 regulation of heterotypic cell-cell adhesion 4/1036 26/18670 0.05324 0.3226 0.2849 IL1B/TNF/LCK/MBP 4 GO:0071624 positive regulation of granulocyte chemotaxis 4/1036 26/18670 0.05324 0.3226 0.2849 C1QBP/DAPK2/IL23A/LBP 4 GO:1905048 regulation of metallopeptidase activity 4/1036 26/18670 0.05324 0.3226 0.2849 RECK/MBP/MAPK3/TIMP2 4 GO:0060401 cytosolic calcium ion transport 15/1036 171/18670 0.05339 0.3231 0.2853 CXCL11/P2RX5/CLIC2/ATP2A2/FYN/NTSR1/FAM155B/TRPM2/LCK/PLCB3/JPH3/MCOLN1/TRPM1/GRIN2D/ATG5 15 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 10/1036 101/18670 0.05357 0.3233 0.2855 HLA-DRB4/KIF2A/CTSD/HLA-DQB1/DYNLL1/HLA-DOB/KIFAP3/AP2B1/DCTN6/SEC24A 10 GO:1903008 organelle disassembly 10/1036 101/18670 0.05357 0.3233 0.2855 OPTN/ATG14/ZFAND1/MTIF2/CSNK2A2/DNM1L/VRK1/DYRK3/HAX1/ATG5 10 GO:0032388 positive regulation of intracellular transport 18/1036 215/18670 0.05397 0.3233 0.2855 IFNG/IL1B/LDLRAP1/FYN/ZFAND1/CSNK2A2/MAP2/EHD2/DNM1L/EDEM1/ICE1/SCP2/SPHK2/PCM1/RIOK2/MFF/PIK3R1/FEZ1 18 GO:1905952 regulation of lipid localization 14/1036 157/18670 0.05416 0.3233 0.2855 NFKB1/IL6/IL1B/CETP/LDLRAP1/NTSR1/CRY1/TNF/ATP8A1/LRP1/SCP2/PON1/NCOR1/CYP4A11 14 GO:0051260 protein homooligomerization 27/1036 351/18670 0.05428 0.3233 0.2855 CD247/CRYZ/CEP57/CAT/CRTC3/CCDC88C/DERL1/PRF1/P2RX1/USP16/TRPM2/TRMT61B/DNM1L/ELAVL1/GLRA1/OTC/KCNC3/PFKP/KCNS1/P2RX6/EHD3/MFF/MCOLN1/CD3E/TERF1/ACAT1/POLQ 27 GO:0016054 organic acid catabolic process 22/1036 275/18670 0.05458 0.3233 0.2855 ABAT/ABCD3/ADO/DLD/ENOSF1/KMO/ACADM/LIPE/QDPR/AHCY/ETFA/BCKDHA/MCCC1/SCP2/KYNU/PON1/OTC/CBS/GAD2/CYP4A11/ACAT1/CYP4F12 22 GO:0046395 carboxylic acid catabolic process 22/1036 275/18670 0.05458 0.3233 0.2855 ABAT/ABCD3/ADO/DLD/ENOSF1/KMO/ACADM/LIPE/QDPR/AHCY/ETFA/BCKDHA/MCCC1/SCP2/KYNU/PON1/OTC/CBS/GAD2/CYP4A11/ACAT1/CYP4F12 22 GO:0031056 regulation of histone modification 13/1036 143/18670 0.05467 0.3233 0.2855 AUTS2/BRD7/CTR9/IL1B/FLCN/SART3/MAPK3/LIF/SPHK2/SPI1/ZNHIT1/ATRX/ATG5 13 GO:0007596 blood coagulation 26/1036 336/18670 0.05483 0.3233 0.2855 ABAT/IL6/C1QBP/P2RX5/PRKCH/ENPP4/METAP1/PRKCQ/GNAS/PRKACB/P2RX1/FYN/MICAL1/F12/CLEC1B/WAS/EHD2/LCK/PRKAR2B/PIK3CA/MAPK3/DGKZ/CD9/P2RX6/EHD3/PIK3R1 26 GO:0003206 cardiac chamber morphogenesis 12/1036 129/18670 0.05483 0.3233 0.2855 SOS1/TGFBR2/ACVR1/TNNI1/TGFBR3/SMARCD3/PARVA/RARA/RBM15/CITED2/HEG1/FZD2 12 GO:0071482 cellular response to light stimulus 12/1036 129/18670 0.05483 0.3233 0.2855 PCNA/PARP1/MYC/METAP1/CRY1/FNTA/ATR/METAP2/NPM1/STK11/TRPM1/PIK3R1 12 GO:0070098 chemokine-mediated signaling pathway 9/1036 88/18670 0.05493 0.3233 0.2855 CXCL11/CCL5/CCR3/CXCR6/CXCR4/RBM15/CCL11/CCL25/CCL23 9 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 9/1036 88/18670 0.05493 0.3233 0.2855 GCLC/FYN/CRY1/TRIM44/RPS7/FBXO5/HMG20A/RPL11/ATG5 9 GO:0001933 negative regulation of protein phosphorylation 32/1036 429/18670 0.05496 0.3233 0.2855 AIDA/FKBP8/MYC/RANBP9/IFNG/ATG14/DUSP2/IL1B/FLCN/DACT1/NCK1/STK38/CBLB/MICAL1/PTPN22/ATF3/NNT/TRIB2/CDK5RAP1/PEBP1/NPM1/PRKAR2B/GPD1L/LIF/DUSP21/HEG1/IGBP1/PSMD10/ZMYND11/NCOR1/PAQR3/IPO7 32 GO:1905818 regulation of chromosome separation 7/1036 62/18670 0.05511 0.3233 0.2855 CDC23/ANAPC5/PSMG2/CSNK2A2/NDC80/RIOK2/FBXO5 7 GO:0044282 small molecule catabolic process 33/1036 445/18670 0.05545 0.3233 0.2855 ABAT/ABCD3/PGK1/DERA/ADO/OXCT1/ENPP4/DLD/ENOSF1/KMO/NTSR1/ACADM/ADPRM/LIPE/QDPR/AHCY/ETFA/BCKDHA/MCCC1/SCP2/KYNU/PON1/OTC/CBS/APOBEC3G/AKR1C3/ALDH3B1/PFKP/NUDT9/GAD2/CYP4A11/ACAT1/CYP4F12 33 GO:0001780 neutrophil homeostasis 3/1036 16/18670 0.05554 0.3233 0.2855 IL6/PDE4B/ANXA1 3 GO:0002643 regulation of tolerance induction 3/1036 16/18670 0.05554 0.3233 0.2855 TGFBR2/CD3E/CLC 3 GO:0002739 regulation of cytokine secretion involved in immune response 3/1036 16/18670 0.05554 0.3233 0.2855 TNF/MAPK3/ATG5 3 GO:0002830 positive regulation of type 2 immune response 3/1036 16/18670 0.05554 0.3233 0.2855 IL6/RARA/RSAD2 3 GO:0006047 UDP-N-acetylglucosamine metabolic process 3/1036 16/18670 0.05554 0.3233 0.2855 GNE/UAP1L1/GFPT1 3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate 3/1036 16/18670 0.05554 0.3233 0.2855 DLD/PDHX/PDHB 3 GO:0014048 regulation of glutamate secretion 3/1036 16/18670 0.05554 0.3233 0.2855 KMO/NTSR1/TRH 3 GO:0030575 nuclear body organization 3/1036 16/18670 0.05554 0.3233 0.2855 USPL1/DYRK3/SERBP1 3 GO:0032305 positive regulation of icosanoid secretion 3/1036 16/18670 0.05554 0.3233 0.2855 IL1B/NTSR1/CYP4A11 3 GO:0032695 negative regulation of interleukin-12 production 3/1036 16/18670 0.05554 0.3233 0.2855 SLAMF1/NFKB1/C1QBP 3 GO:0033631 cell-cell adhesion mediated by integrin 3/1036 16/18670 0.05554 0.3233 0.2855 CCL5/ITGA4/CD3E 3 GO:0034116 positive regulation of heterotypic cell-cell adhesion 3/1036 16/18670 0.05554 0.3233 0.2855 IL1B/TNF/LCK 3 GO:0043174 nucleoside salvage 3/1036 16/18670 0.05554 0.3233 0.2855 DCK/UCKL1/APRT 3 GO:0045116 protein neddylation 3/1036 16/18670 0.05554 0.3233 0.2855 NAE1/RBX1/RPL11 3 GO:0051444 negative regulation of ubiquitin-protein transferase activity 3/1036 16/18670 0.05554 0.3233 0.2855 RPS7/FBXO5/RPL11 3 GO:0051447 negative regulation of meiotic cell cycle 3/1036 16/18670 0.05554 0.3233 0.2855 PRKACB/LIF/FBXO5 3 GO:0070200 establishment of protein localization to telomere 3/1036 16/18670 0.05554 0.3233 0.2855 CCT7/CCT2/TERF1 3 GO:0090083 regulation of inclusion body assembly 3/1036 16/18670 0.05554 0.3233 0.2855 SACS/DNAJB1/PSMC5 3 GO:2001170 negative regulation of ATP biosynthetic process 3/1036 16/18670 0.05554 0.3233 0.2855 PARP1/FLCN/HDAC4 3 GO:0003281 ventricular septum development 8/1036 75/18670 0.0556 0.3233 0.2855 TGFBR2/ACVR1/TGFBR3/RBM15/CITED2/HEG1/AP2B1/FZD2 8 GO:0060402 calcium ion transport into cytosol 14/1036 158/18670 0.05654 0.3279 0.2896 CXCL11/P2RX5/CLIC2/FYN/NTSR1/FAM155B/TRPM2/LCK/PLCB3/JPH3/MCOLN1/TRPM1/GRIN2D/ATG5 14 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 10/1036 102/18670 0.05658 0.3279 0.2896 HLA-DRB4/KIF2A/CTSD/HLA-DQB1/DYNLL1/HLA-DOB/KIFAP3/AP2B1/DCTN6/SEC24A 10 GO:2000379 positive regulation of reactive oxygen species metabolic process 10/1036 102/18670 0.05658 0.3279 0.2896 IFNG/TGFBR2/IL1B/PTX3/TNF/NNT/HDAC4/TLR6/AKR1C3/SOD1 10 GO:1905475 regulation of protein localization to membrane 16/1036 187/18670 0.05673 0.3285 0.29 IFNG/PRKCH/LDLRAP1/GZMB/FYN/TNF/YWHAQ/LRP1/STX8/ANXA13/RANGRF/PMAIP1/ACSL3/MFF/AP2B1/PIK3R1 16 GO:0034656 nucleobase-containing small molecule catabolic process 6/1036 50/18670 0.05723 0.3297 0.2912 DERA/ENPP4/ADPRM/AHCY/APOBEC3G/NUDT9 6 GO:1900180 regulation of protein localization to nucleus 11/1036 116/18670 0.05736 0.3297 0.2912 PARP1/IFNG/CCT7/FLCN/FYN/CCT2/CD2AP/LIF/STK11/LILRB4/PIK3R1 11 GO:0009225 nucleotide-sugar metabolic process 5/1036 38/18670 0.05738 0.3297 0.2912 SLC35D1/UGP2/GNE/UAP1L1/GFPT1 5 GO:0032350 regulation of hormone metabolic process 5/1036 38/18670 0.05738 0.3297 0.2912 NFKB1/IFNG/IL1B/TNF/AKR1C3 5 GO:0046329 negative regulation of JNK cascade 5/1036 38/18670 0.05738 0.3297 0.2912 AIDA/DACT1/PTPN22/ZMYND11/NCOR1 5 GO:1904037 positive regulation of epithelial cell apoptotic process 5/1036 38/18670 0.05738 0.3297 0.2912 IL6/ITGA4/TIA1/PIAS4/AKR1C3 5 GO:1905898 positive regulation of response to endoplasmic reticulum stress 5/1036 38/18670 0.05738 0.3297 0.2912 NCK1/XBP1/EDEM1/PMAIP1/PIK3R1 5 GO:0001659 temperature homeostasis 15/1036 173/18670 0.05795 0.3326 0.2937 ABAT/IL1A/IL1B/FLCN/GNAS/NTSR1/PLCL1/TNF/TRPM2/CXCR4/STK11/FH/IL15/NMU/ZNF516 15 GO:0032602 chemokine production 9/1036 89/18670 0.05825 0.3337 0.2947 IL6/IFNG/IL1B/TNF/LRP1/TLR3/MBP/ELANE/LBP 9 GO:0006909 phagocytosis 28/1036 369/18670 0.05826 0.3337 0.2947 CD247/SLAMF1/IFNG/IL2RB/IL1B/PTX3/NCK1/FYN/TNF/WAS/ANXA1/LRP1/CYFIP2/IL15RA/RARA/PIK3CA/MAPK3/ELANE/ELMO2/IL15/FCN1/SOD1/SH3BP1/PIK3R1/TRBC1/BCR/LBP/ATG5 28 GO:0034394 protein localization to cell surface 7/1036 63/18670 0.05917 0.3383 0.2988 CD247/LEPROTL1/TNF/EMP2/GPD1L/RANGRF/FCN1 7 GO:0046785 microtubule polymerization 8/1036 76/18670 0.05926 0.3383 0.2988 RANBP9/TUBGCP2/MAP2/RANGRF/CLASP1/FBXO5/DYRK1A/TERF1 8 GO:0060411 cardiac septum morphogenesis 8/1036 76/18670 0.05926 0.3383 0.2988 TGFBR2/ACVR1/TGFBR3/PARVA/RARA/RBM15/CITED2/FZD2 8 GO:0000460 maturation of 5.8S rRNA 4/1036 27/18670 0.05986 0.3385 0.2989 EXOSC8/RRS1/RPS21/WDR12 4 GO:0002825 regulation of T-helper 1 type immune response 4/1036 27/18670 0.05986 0.3385 0.2989 IL1B/IL12B/ANXA1/IL23A 4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 4/1036 27/18670 0.05986 0.3385 0.2989 CDC25B/SMARCD3/FBXO5/CDC7 4 GO:0032673 regulation of interleukin-4 production 4/1036 27/18670 0.05986 0.3385 0.2989 PRKCQ/RARA/CD83/CD3E 4 GO:0045671 negative regulation of osteoclast differentiation 4/1036 27/18670 0.05986 0.3385 0.2989 TLR3/LILRB3/LILRB4/PIK3R1 4 GO:0060384 innervation 4/1036 27/18670 0.05986 0.3385 0.2989 ITGA4/LRIG1/SULF1/GABRB2 4 GO:0071514 genetic imprinting 4/1036 27/18670 0.05986 0.3385 0.2989 CTR9/GNAS/PIK3CA/KCNQ1 4 GO:2000144 positive regulation of DNA-templated transcription, initiation 4/1036 27/18670 0.05986 0.3385 0.2989 PSMC2/BCLAF1/SETX/PSMC5 4 GO:2000191 regulation of fatty acid transport 4/1036 27/18670 0.05986 0.3385 0.2989 IL1B/NTSR1/NCOR1/CYP4A11 4 GO:0019722 calcium-mediated signaling 18/1036 218/18670 0.06012 0.339 0.2993 DYRK2/HINT1/CCR3/TRAT1/P2RX5/CLIC2/ATP2A2/CXCR6/ERBB3/TNF/TRPM2/CXCR4/ATP1B1/JPH3/HDAC4/MCOLN1/CD3E/GRIN2D 18 GO:0030183 B cell differentiation 12/1036 131/18670 0.06027 0.339 0.2993 ITM2A/POU2F2/MALT1/ITGA4/MSH2/XBP1/HDAC4/LYL1/GPR183/SLAMF8/PIK3R1/ZBTB7A 12 GO:0098754 detoxification 12/1036 131/18670 0.06027 0.339 0.2993 CAT/CLIC2/SOD3/SESN1/HP/TNF/NNT/MARC1/GPX7/PRDX6/SOD1/IPCEF1 12 GO:0060147 regulation of posttranscriptional gene silencing 11/1036 117/18670 0.06029 0.339 0.2993 NUP107/NUP37/ZFP36/NUP205/ELAVL1/PUM1/NUP85/NCOR1/NUP160/NUP214/FXR1 11 GO:0060966 regulation of gene silencing by RNA 11/1036 117/18670 0.06029 0.339 0.2993 NUP107/NUP37/ZFP36/NUP205/ELAVL1/PUM1/NUP85/NCOR1/NUP160/NUP214/FXR1 11 GO:0006941 striated muscle contraction 15/1036 174/18670 0.06032 0.339 0.2993 SYNM/CLIC2/MYL1/ATP2A2/CHGA/PDE4B/TNNI1/SCN10A/CXCR4/PIK3CA/GPD1L/ATP1B1/HDAC4/EHD3/KCNQ1 15 GO:0000819 sister chromatid segregation 16/1036 189/18670 0.06127 0.3439 0.3037 SFPQ/AURKC/CDC23/ANAPC5/ZWINT/PSMG2/HIRA/PHB2/NDC80/TNKS/RIOK2/FBXO5/RRS1/ATRX/PRC1/SMC2 16 GO:0032680 regulation of tumor necrosis factor production 14/1036 160/18670 0.06151 0.3449 0.3046 SLAMF1/IFNG/CD2/GPR18/IL12B/ZFP36/PTPN22/RASGRP1/TLR3/IL23A/RARA/PIK3R1/UBE2J1/LBP 14 GO:0071674 mononuclear cell migration 9/1036 90/18670 0.06169 0.3456 0.3052 CCL5/IL6/TNF/ANXA1/MAPK3/CCL11/CCL25/CCL23/SLAMF8 9 GO:0030071 regulation of mitotic metaphase/anaphase transition 6/1036 51/18670 0.06196 0.3467 0.3062 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0140014 mitotic nuclear division 21/1036 264/18670 0.0622 0.3476 0.3069 IL1A/KIF2A/IL1B/AURKC/CDC23/ANAPC5/USP16/ZWINT/PSMG2/HIRA/PHB2/NDC80/TNKS/RIOK2/CLASP1/FBXO5/RRS1/PKMYT1/ATRX/PRC1/SMC2 21 GO:0006816 calcium ion transport 32/1036 434/18670 0.06224 0.3476 0.3069 CXCL11/CCL5/P2RX5/CLIC2/ATP2A2/P2RX1/FYN/ORAI3/NTSR1/PDE4B/FAM155B/TRPM2/CXCR4/PHB2/DNM1L/BEST1/LCK/SLC8A2/PLCB3/ATP1B1/SPHK2/JPH3/CACNB4/CSN2/ATP2B2/TSPAN13/TRPM6/EHD3/MCOLN1/TRPM1/GRIN2D/ATG5 32 GO:0035264 multicellular organism growth 13/1036 146/18670 0.06247 0.3485 0.3077 FKBP8/ARID5B/SOS1/GNAS/SLC12A5/RARA/PIK3CA/HEG1/GHRHR/SOD1/ATRX/XRCC2/TMED2 13 GO:0030488 tRNA methylation 5/1036 39/18670 0.06295 0.3496 0.3087 TARBP1/TRMT61B/MTO1/TRMT5/TRMT112 5 GO:0045911 positive regulation of DNA recombination 5/1036 39/18670 0.06295 0.3496 0.3087 PARP1/TNFSF13/WAS/MSH2/TBX21 5 GO:0050856 regulation of T cell receptor signaling pathway 5/1036 39/18670 0.06295 0.3496 0.3087 TRAT1/MALT1/PTPN22/LCK/LILRB4 5 GO:0051180 vitamin transport 5/1036 39/18670 0.06295 0.3496 0.3087 FOLR3/SLC25A32/SLC22A13/LMBRD1/TCN2 5 GO:0006278 RNA-dependent DNA biosynthetic process 8/1036 77/18670 0.06307 0.3496 0.3087 CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/RPA1/TERF1 8 GO:0031397 negative regulation of protein ubiquitination 8/1036 77/18670 0.06307 0.3496 0.3087 GCLC/FYN/CRY1/TRIM44/RPS7/FBXO5/RPL11/ATG5 8 GO:0007599 hemostasis 26/1036 341/18670 0.06313 0.3496 0.3087 ABAT/IL6/C1QBP/P2RX5/PRKCH/ENPP4/METAP1/PRKCQ/GNAS/PRKACB/P2RX1/FYN/MICAL1/F12/CLEC1B/WAS/EHD2/LCK/PRKAR2B/PIK3CA/MAPK3/DGKZ/CD9/P2RX6/EHD3/PIK3R1 26 GO:0048511 rhythmic process 23/1036 295/18670 0.06333 0.3497 0.3088 PCNA/CREM/SFPQ/PTX3/RORA/PSPC1/MAGED1/CRY1/PPP1CC/SIAH2/BMPR1B/DNM1L/HNRNPR/AHCY/TIMP4/KDM5C/GHRHR/DYRK1A/SETX/NMU/NCOR1/ADNP/GFPT1 23 GO:0030032 lamellipodium assembly 7/1036 64/18670 0.06341 0.3497 0.3088 AUTS2/NCK1/WAS/ARHGEF7/NUP85/HDAC4/ABLIM1 7 GO:0046834 lipid phosphorylation 7/1036 64/18670 0.06341 0.3497 0.3088 PIK3CA/SPHK2/DGKZ/PIK3C2A/AGK/PIK3R1/CERK 7 GO:0048247 lymphocyte chemotaxis 7/1036 64/18670 0.06341 0.3497 0.3088 CXCL11/CCL5/CH25H/CCL11/GPR183/CCL25/CCL23 7 GO:0060047 heart contraction 22/1036 280/18670 0.06382 0.3516 0.3105 CLIC2/MYL1/ATP2A2/CHGA/PDE4B/SCN10A/CXCR4/DNM1L/SLC8A2/PIK3CA/GPD1L/ATP1B1/HDAC4/CHRM2/CACNB4/RANGRF/ATP2B2/EHD3/SOD1/KCNQ1/NMU/ATG5 22 GO:0006979 response to oxidative stress 33/1036 451/18670 0.06416 0.3517 0.3106 CD38/PCNA/PARP1/IL6/SFPQ/CAT/ATP2A2/SOD3/SESN1/MTR/HP/CYCS/GCLC/FYN/TNF/TRPM2/RWDD1/ANXA1/LANCL1/NDUFA6/NDUFB4/PRKRA/MAPK3/PDE8A/TLR6/GPX7/AKR1C3/ALDH3B1/PRDX6/SETX/SOD1/IPCEF1/CBX8 33 GO:0070838 divalent metal ion transport 35/1036 483/18670 0.06471 0.3517 0.3106 CXCL11/CCL5/IFNG/P2RX5/CLIC2/ATP2A2/P2RX1/FYN/ORAI3/NTSR1/PDE4B/FAM155B/TRPM2/CXCR4/PHB2/DNM1L/BEST1/LCK/SLC8A2/PLCB3/ATP1B1/SPHK2/SLC30A9/JPH3/CACNB4/CSN2/ATP2B2/TSPAN13/TRPM6/EHD3/MCOLN1/TRPM1/SLC39A6/GRIN2D/ATG5 35 GO:0002418 immune response to tumor cell 3/1036 17/18670 0.06476 0.3517 0.3106 IL12B/PRF1/ADAM15 3 GO:0002693 positive regulation of cellular extravasation 3/1036 17/18670 0.06476 0.3517 0.3106 ITGA4/ELANE/CD99 3 GO:0010715 regulation of extracellular matrix disassembly 3/1036 17/18670 0.06476 0.3517 0.3106 IL6/LRP1/CLASP1 3 GO:0033262 regulation of nuclear cell cycle DNA replication 3/1036 17/18670 0.06476 0.3517 0.3106 ATRX/TERF1/CDC7 3 GO:0051709 regulation of killing of cells of other organism 3/1036 17/18670 0.06476 0.3517 0.3106 IFNG/PRF1/PGLYRP4 3 GO:0060080 inhibitory postsynaptic potential 3/1036 17/18670 0.06476 0.3517 0.3106 ABAT/NTSR1/GLRA1 3 GO:0060263 regulation of respiratory burst 3/1036 17/18670 0.06476 0.3517 0.3106 SLAMF8/BCR/LBP 3 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 3/1036 17/18670 0.06476 0.3517 0.3106 P2RX1/CALB2/ATP2B2 3 GO:1903209 positive regulation of oxidative stress-induced cell death 3/1036 17/18670 0.06476 0.3517 0.3106 SFPQ/TLR6/SOD1 3 GO:1904355 positive regulation of telomere capping 3/1036 17/18670 0.06476 0.3517 0.3106 PRKCQ/MAPK3/TNKS 3 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 3/1036 17/18670 0.06476 0.3517 0.3106 ITGA4/TNF/ELANE 3 GO:1905331 negative regulation of morphogenesis of an epithelium 3/1036 17/18670 0.06476 0.3517 0.3106 TNF/SULF1/CLASP1 3 GO:0050817 coagulation 26/1036 342/18670 0.06489 0.3521 0.3109 ABAT/IL6/C1QBP/P2RX5/PRKCH/ENPP4/METAP1/PRKCQ/GNAS/PRKACB/P2RX1/FYN/MICAL1/F12/CLEC1B/WAS/EHD2/LCK/PRKAR2B/PIK3CA/MAPK3/DGKZ/CD9/P2RX6/EHD3/PIK3R1 26 GO:0006637 acyl-CoA metabolic process 10/1036 105/18670 0.06627 0.3588 0.3169 SUCLA2/DLD/PDHX/PPCS/SUCLG2/KYNU/SUCLG1/ACSL3/PDHB/ACAT1 10 GO:0035383 thioester metabolic process 10/1036 105/18670 0.06627 0.3588 0.3169 SUCLA2/DLD/PDHX/PPCS/SUCLG2/KYNU/SUCLG1/ACSL3/PDHB/ACAT1 10 GO:0001773 myeloid dendritic cell activation 4/1036 28/18670 0.0669 0.3608 0.3186 SLAMF1/TGFBR2/CD2/SPI1 4 GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 4/1036 28/18670 0.0669 0.3608 0.3186 ITGA4/TNF/ELANE/CCL25 4 GO:0006301 postreplication repair 6/1036 52/18670 0.06691 0.3608 0.3186 PCNA/RCHY1/MSH2/UBA52/UBB/RPA1 6 GO:0009620 response to fungus 6/1036 52/18670 0.06691 0.3608 0.3186 PTX3/MALT1/CHGA/ELANE/CTSG/ATG5 6 GO:0002548 monocyte chemotaxis 7/1036 65/18670 0.06783 0.365 0.3223 CCL5/IL6/ANXA1/CCL11/CCL25/CCL23/SLAMF8 7 GO:0014823 response to activity 7/1036 65/18670 0.06783 0.365 0.3223 OXCT1/CAT/GCLC/CRY1/CXCR4/ADSL/TOMM20 7 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 16/1036 192/18670 0.06853 0.3684 0.3253 CCL5/IL6/IFNG/IL12B/ACVR1/FYN/ERBB3/TNF/IL23A/LIF/IL15/HAX1/CD3E/ADNP/IL3/NCAPG2 16 GO:0035735 intraciliary transport involved in cilium assembly 5/1036 40/18670 0.0688 0.3692 0.326 IFT22/DYNLL1/HSPB11/KIFAP3/PCM1 5 GO:2000008 regulation of protein localization to cell surface 5/1036 40/18670 0.0688 0.3692 0.326 CD247/LEPROTL1/TNF/GPD1L/RANGRF 5 GO:0032872 regulation of stress-activated MAPK cascade 19/1036 237/18670 0.06897 0.3697 0.3264 AIDA/SLAMF1/MYC/IL1B/DACT1/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP4K5/MAPK3/MAP4K2/TLR6/IGBP1/DAXX/ZMYND11/NCOR1/EDA2R 19 GO:0006936 muscle contraction 27/1036 360/18670 0.06934 0.3713 0.3278 CD38/SYNM/ABAT/CLIC2/MYL1/ATP2A2/LTB4R/P2RX1/HSPB6/CHGA/PDE4B/TNNI1/SCN10A/CXCR4/SULF1/GLRA1/PIK3CA/GPD1L/ATP1B1/HDAC4/CHRM2/PIK3C2A/P2RX6/EHD3/SOD1/KCNQ1/NMU 27 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 14/1036 163/18670 0.06949 0.3715 0.328 SLAMF1/IFNG/CD2/GPR18/IL12B/ZFP36/PTPN22/RASGRP1/TLR3/IL23A/RARA/PIK3R1/UBE2J1/LBP 14 GO:0003014 renal system process 11/1036 120/18670 0.06968 0.3715 0.328 HSD11B2/PRKACB/EMP2/SULF1/PRKAR2B/AKR1B1/AKR1C3/KCNQ1/CYP4A11/BCR/CYP4F12 11 GO:0042136 neurotransmitter biosynthetic process 10/1036 106/18670 0.06972 0.3715 0.328 ABAT/IFNG/IL1B/PTX3/RORA/TNF/TLR6/GAD2/KHSRP/SLC1A3 10 GO:1901606 alpha-amino acid catabolic process 10/1036 106/18670 0.06972 0.3715 0.328 DLD/KMO/QDPR/AHCY/MCCC1/KYNU/OTC/CBS/GAD2/ACAT1 10 GO:1901989 positive regulation of cell cycle phase transition 10/1036 106/18670 0.06972 0.3715 0.328 CDC25B/ANAPC5/ANKRD17/ANXA1/PHB2/SMARCD3/NPM1/DYRK3/FBXO5/CDC7 10 GO:0009416 response to light stimulus 24/1036 314/18670 0.07036 0.3745 0.3307 PCNA/PARP1/DDHD2/MYC/METAP1/CAT/IL12B/CRY1/PPP1CC/FNTA/USP1/MSH2/HRH2/BEST1/ATR/METAP2/NPM1/HMGN1/ELANE/STK11/NMU/TRPM1/PIK3R1/SLC1A3 24 GO:0031668 cellular response to extracellular stimulus 21/1036 268/18670 0.07044 0.3746 0.3308 ATG14/ITGA4/ITGA6/SESN1/FYN/ATF3/DNM1L/ASGR1/XBP1/USF2/MAPK3/TNKS/CBS/AKR1C3/IL15/PMAIP1/SOD1/TRIM24/SLC38A2/ADNP/ATG5 21 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 27/1036 361/18670 0.07117 0.3781 0.3339 IL6/IL1B/C1QBP/POU2F2/MALT1/BTN3A3/RORA/CTSC/TNFSF13/PRKCQ/IL12B/HLA-DQB1/PRF1/CD8A/TNF/C8B/WAS/ANXA1/MSH2/CD1A/TBX21/EMP2/IL23A/RSAD2/RFTN1/TRBC1/CLC 27 GO:0036297 interstrand cross-link repair 6/1036 53/18670 0.07209 0.3822 0.3375 USP1/ATR/FANCF/UBA52/UBB/RPA1 6 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 6/1036 53/18670 0.07209 0.3822 0.3375 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0001889 liver development 12/1036 135/18670 0.07218 0.3823 0.3376 PCNA/ARID5B/TGFBR3/ANXA1/CSNK2A2/XBP1/QDPR/RARA/PIK3CA/OTC/CITED2/ACAT1 12 GO:0070588 calcium ion transmembrane transport 24/1036 315/18670 0.07236 0.3828 0.3381 CXCL11/CLIC2/ATP2A2/FYN/ORAI3/NTSR1/PDE4B/FAM155B/TRPM2/PHB2/LCK/SLC8A2/PLCB3/ATP1B1/JPH3/CACNB4/ATP2B2/TSPAN13/TRPM6/EHD3/MCOLN1/TRPM1/GRIN2D/ATG5 24 GO:0006513 protein monoubiquitination 7/1036 66/18670 0.07243 0.3828 0.3381 CTR9/SKP1/TRIM37/RBX1/CUL1/WAC/UBB 7 GO:0051341 regulation of oxidoreductase activity 10/1036 107/18670 0.07329 0.3851 0.3401 NFKB1/IFNG/IL1B/HP/TNF/GZMA/PHB2/OXA1L/SPHK2/SLAMF8 10 GO:0070302 regulation of stress-activated protein kinase signaling cascade 19/1036 239/18670 0.07358 0.3851 0.3401 AIDA/SLAMF1/MYC/IL1B/DACT1/TNF/PTPN22/IL36A/RASGRP1/TLR3/MAP4K5/MAPK3/MAP4K2/TLR6/IGBP1/DAXX/ZMYND11/NCOR1/EDA2R 19 GO:2000116 regulation of cysteine-type endopeptidase activity 19/1036 239/18670 0.07358 0.3851 0.3401 MYC/MALT1/LAMP3/CTSD/P2RX1/CYCS/FYN/MICAL1/BIRC3/TNF/SIAH2/CYFIP2/LCK/HSPE1/CST7/CSN2/IGBP1/PMAIP1/RPS6KA3 19 GO:0097191 extrinsic apoptotic signaling pathway 18/1036 224/18670 0.07383 0.3851 0.3401 IL1A/IFNG/IL1B/MOAP1/ITGA6/GCLC/ACVR1/FYN/ERBB3/TNF/SIAH2/ATF3/BMPR1B/TLR3/DAXX/PMAIP1/ZMYND11/PIK3R1 18 GO:0006006 glucose metabolic process 17/1036 209/18670 0.07388 0.3851 0.3401 DYRK2/MDH1/CREM/PGK1/DUSP12/PASK/RORA/CRY1/COX11/TNF/ATF3/CLK2/PIK3CA/HECTD4/PFKP/PMAIP1/PDHB 17 GO:0007628 adult walking behavior 4/1036 29/18670 0.07435 0.3851 0.3401 NPC1/GLRA1/TRH/EFNB3 4 GO:0010390 histone monoubiquitination 4/1036 29/18670 0.07435 0.3851 0.3401 CTR9/SKP1/TRIM37/WAC 4 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 4/1036 29/18670 0.07435 0.3851 0.3401 CLIC2/ATP2A2/ATP1B1/HDAC4 4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 4/1036 29/18670 0.07435 0.3851 0.3401 FLCN/TGFBR3/STK11/CITED2 4 GO:0044030 regulation of DNA methylation 4/1036 29/18670 0.07435 0.3851 0.3401 PARP1/MYC/PIK3CA/SPI1 4 GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 4/1036 29/18670 0.07435 0.3851 0.3401 FLCN/TGFBR3/STK11/CITED2 4 GO:2000036 regulation of stem cell population maintenance 4/1036 29/18670 0.07435 0.3851 0.3401 LBH/NCOA3/ELAVL1/ZNF706 4 GO:0007250 activation of NF-kappaB-inducing kinase activity 3/1036 18/18670 0.07462 0.3851 0.3401 MALT1/TLR3/TLR6 3 GO:0030809 negative regulation of nucleotide biosynthetic process 3/1036 18/18670 0.07462 0.3851 0.3401 PARP1/FLCN/HDAC4 3 GO:0032693 negative regulation of interleukin-10 production 3/1036 18/18670 0.07462 0.3851 0.3401 IL12B/TRIB2/IL23A 3 GO:0043555 regulation of translation in response to stress 3/1036 18/18670 0.07462 0.3851 0.3401 NCK1/NPM1/RPS6KA3 3 GO:0051023 regulation of immunoglobulin secretion 3/1036 18/18670 0.07462 0.3851 0.3401 IL6/TNF/XBP1 3 GO:0090196 regulation of chemokine secretion 3/1036 18/18670 0.07462 0.3851 0.3401 TNF/LRP1/MBP 3 GO:0090330 regulation of platelet aggregation 3/1036 18/18670 0.07462 0.3851 0.3401 ABAT/PRKCQ/CD9 3 GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/1036 18/18670 0.07462 0.3851 0.3401 BTG2/ZFP36/PABPC1 3 GO:1900221 regulation of amyloid-beta clearance 3/1036 18/18670 0.07462 0.3851 0.3401 IFNG/TNF/LRP1 3 GO:1900372 negative regulation of purine nucleotide biosynthetic process 3/1036 18/18670 0.07462 0.3851 0.3401 PARP1/FLCN/HDAC4 3 GO:1904872 regulation of telomerase RNA localization to Cajal body 3/1036 18/18670 0.07462 0.3851 0.3401 CCT7/CCT2/SHQ1 3 GO:2000193 positive regulation of fatty acid transport 3/1036 18/18670 0.07462 0.3851 0.3401 IL1B/NTSR1/CYP4A11 3 GO:0006458 'de novo' protein folding 5/1036 41/18670 0.07495 0.3851 0.3401 HSPA9/CCT2/DNAJB1/HSPE1/HSPA14 5 GO:0019985 translesion synthesis 5/1036 41/18670 0.07495 0.3851 0.3401 PCNA/RCHY1/UBA52/UBB/RPA1 5 GO:0050798 activated T cell proliferation 5/1036 41/18670 0.07495 0.3851 0.3401 IL12B/FYN/IL23A/SATB1/CLC 5 GO:0070317 negative regulation of G0 to G1 transition 5/1036 41/18670 0.07495 0.3851 0.3401 RBBP4/YAF2/UXT/RBBP7/CDC7 5 GO:0150077 regulation of neuroinflammatory response 5/1036 41/18670 0.07495 0.3851 0.3401 IL6/IL1B/CTSC/TNF/CST7 5 GO:0010639 negative regulation of organelle organization 29/1036 395/18670 0.07607 0.3898 0.3442 PARP1/FLCN/INSIG1/ADD3/SLC25A5/TRIM37/SCFD1/PSMG2/WAS/CKAP2/MAP2/DNM1L/NPM1/TBC1D4/NDC80/LIF/TNKS/SPHK2/CLASP1/FBXO5/SPI1/PSMD10/DYRK1A/VAT1/ATRX/TERF1/SLC35F6/ATG5/FEZ1 29 GO:0070997 neuron death 26/1036 348/18670 0.07619 0.3898 0.3442 PARP1/NAE1/CCL5/IFNG/RASA1/KMO/BTG2/GCLC/FYN/CHGA/ERBB3/TNF/LANCL1/MSH2/LRP1/PIK3CA/RRAS2/HDAC4/GABRB2/TLR6/DAXX/UBB/SOD1/AP2B1/ADNP/XRCC2 26 GO:0060828 regulation of canonical Wnt signaling pathway 22/1036 286/18670 0.07627 0.3898 0.3442 NFKB1/DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/RBX1/RECK/CAPRIN2/PSME4/PSMD12/MLLT3/TNKS/PSMB1/BICC1/STK11/PSMD10/PSMC5/PSMA3 22 GO:0007160 cell-matrix adhesion 18/1036 225/18670 0.0763 0.3898 0.3442 CD96/MADCAM1/ITGA4/ITGA6/RASA1/ITGA7/LRP1/ARHGEF7/EMP2/ACTN1/CLASP1/ITGB4/CCL25/ADAM15/CD3E/BCAM/PIK3R1/BCR 18 GO:2000377 regulation of reactive oxygen species metabolic process 16/1036 195/18670 0.07634 0.3898 0.3442 IFNG/TGFBR2/IL1B/PTX3/HP/FYN/TNF/NNT/SPHK2/HDAC4/TLR6/AKR1C3/SOD1/KHSRP/BCR/ATG5 16 GO:1903409 reactive oxygen species biosynthetic process 11/1036 122/18670 0.07643 0.3898 0.3442 IFNG/IL1B/PTX3/RORA/FYN/TNF/SPHK2/HDAC4/TLR6/SOD1/KHSRP 11 GO:0043523 regulation of neuron apoptotic process 17/1036 210/18670 0.07644 0.3898 0.3442 PARP1/NAE1/RASA1/BTG2/GCLC/FYN/ERBB3/TNF/LANCL1/MSH2/LRP1/PIK3CA/HDAC4/GABRB2/SOD1/ADNP/XRCC2 17 GO:0050707 regulation of cytokine secretion 17/1036 210/18670 0.07644 0.3898 0.3442 IL1A/IFNG/CD2/IL1B/CD244/TNF/PTPN22/ANXA1/LRP1/RASGRP1/XBP1/MBP/MAPK3/PTGER4/TLR6/FCN1/ATG5 17 GO:0051289 protein homotetramerization 9/1036 94/18670 0.07674 0.3909 0.3452 CD247/CRYZ/CAT/CRTC3/USP16/TRPM2/DNM1L/PFKP/MCOLN1 9 GO:0006275 regulation of DNA replication 10/1036 108/18670 0.07696 0.391 0.3452 PCNA/S100A11/ANKRD17/ATR/GMNN/FBXO5/ATRX/TERF1/DONSON/CDC7 10 GO:0006821 chloride transport 10/1036 108/18670 0.07696 0.391 0.3452 ABCB1/CLIC2/SLC12A5/CLNS1A/BEST1/GLRA1/GABRB2/CA7/GABRP/SLC1A3 10 GO:0051225 spindle assembly 10/1036 108/18670 0.07696 0.391 0.3452 KIF2A/TUBGCP2/AURKC/HAUS2/GOLGA8N/TNKS/CLASP1/FBXO5/RNF4/NCOR1 10 GO:1901617 organic hydroxy compound biosynthetic process 21/1036 271/18670 0.07709 0.391 0.3453 NFKB1/IFNG/IL1B/IDI1/MSMO1/INSIG1/CD244/NTSR1/PLCL1/TNF/NFYB/QDPR/PLCB3/SCP2/SPHK2/CH25H/AKR1B1/AKR1C3/SC5D/SOD1/CNBP 21 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 6/1036 54/18670 0.07749 0.391 0.3453 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0009066 aspartate family amino acid metabolic process 6/1036 54/18670 0.07749 0.391 0.3453 DLD/PLOD1/MTR/AHCY/ASNSD1/AASDHPPT 6 GO:0035384 thioester biosynthetic process 6/1036 54/18670 0.07749 0.391 0.3453 DLD/PDHX/PPCS/ACSL3/PDHB/ACAT1 6 GO:0071616 acyl-CoA biosynthetic process 6/1036 54/18670 0.07749 0.391 0.3453 DLD/PDHX/PPCS/ACSL3/PDHB/ACAT1 6 GO:0090329 regulation of DNA-dependent DNA replication 6/1036 54/18670 0.07749 0.391 0.3453 GMNN/FBXO5/ATRX/TERF1/DONSON/CDC7 6 GO:0097345 mitochondrial outer membrane permeabilization 6/1036 54/18670 0.07749 0.391 0.3453 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0007031 peroxisome organization 8/1036 81/18670 0.07982 0.4017 0.3547 ABCD3/CAT/TMEM135/DNM1L/UBA52/SCP2/UBB/MFF 8 GO:0016126 sterol biosynthetic process 8/1036 81/18670 0.07982 0.4017 0.3547 IDI1/MSMO1/INSIG1/NFYB/CH25H/SC5D/SOD1/CNBP 8 GO:0048708 astrocyte differentiation 8/1036 81/18670 0.07982 0.4017 0.3547 IL6/IFNG/IL1B/TNF/LRP1/MAPK3/LIF/ROR1 8 GO:0051052 regulation of DNA metabolic process 31/1036 429/18670 0.08046 0.4045 0.3572 PCNA/PARP1/MYC/IL6/CCT7/S100A11/FLCN/TNFSF13/PRKCQ/CCT2/GZMA/ANKRD17/USP1/WAS/MSH2/TBX21/ATR/NPM1/GMNN/PIK3CA/MAPK3/TNKS/HNRNPA2B1/FBXO5/SPI1/ATRX/TERF1/DONSON/CDC7/CBX8/POLQ 31 GO:0018212 peptidyl-tyrosine modification 27/1036 366/18670 0.08086 0.4057 0.3583 DYRK2/CCL5/IL6/IFNG/IL12B/CBLB/ACVR1/FYN/ERBB3/TNF/TXK/ITK/CLK2/LCK/IL23A/MAPK3/TPST1/LIF/DYRK3/IL15/DYRK1A/HAX1/ROR1/CD3E/ADNP/IL3/NCAPG2 27 GO:0032259 methylation 27/1036 366/18670 0.08086 0.4057 0.3583 PARP1/MYC/AUTS2/CTR9/TFB2M/FBL/GNAS/MTR/BTG2/EMG1/TARBP1/TRMT61B/AHCY/MTO1/PIK3CA/RBM15/TRMT5/TRMT112/PCMTD2/RBM15B/SPI1/DIMT1/ATRX/GSPT1/METTL4/SATB1/CBLL1 27 GO:0002639 positive regulation of immunoglobulin production 5/1036 42/18670 0.08139 0.4067 0.3591 IL6/TNFSF13/MSH2/TBX21/XBP1 5 GO:0010677 negative regulation of cellular carbohydrate metabolic process 5/1036 42/18670 0.08139 0.4067 0.3591 PASK/CRY1/COX11/CLK2/HDAC4 5 GO:0030517 negative regulation of axon extension 5/1036 42/18670 0.08139 0.4067 0.3591 ARHGAP4/MAP2/SEMA4G/SEMA3G/NTN1 5 GO:0033048 negative regulation of mitotic sister chromatid segregation 5/1036 42/18670 0.08139 0.4067 0.3591 PSMG2/NDC80/TNKS/FBXO5/ATRX 5 GO:0061008 hepaticobiliary system development 12/1036 138/18670 0.08205 0.4067 0.3591 PCNA/ARID5B/TGFBR3/ANXA1/CSNK2A2/XBP1/QDPR/RARA/PIK3CA/OTC/CITED2/ACAT1 12 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 4/1036 30/18670 0.08219 0.4067 0.3591 MOAP1/GZMB/YWHAQ/PMAIP1 4 GO:0006362 transcription elongation from RNA polymerase I promoter 4/1036 30/18670 0.08219 0.4067 0.3591 POLR1B/GTF2H3/TBP/TAF1C 4 GO:0010586 miRNA metabolic process 4/1036 30/18670 0.08219 0.4067 0.3591 DROSHA/NFKB1/PRKRA/KHSRP 4 GO:0045940 positive regulation of steroid metabolic process 4/1036 30/18670 0.08219 0.4067 0.3591 IFNG/IL1B/LDLRAP1/TNF 4 GO:0046640 regulation of alpha-beta T cell proliferation 4/1036 30/18670 0.08219 0.4067 0.3591 TGFBR2/IL12B/IL23A/CD3E 4 GO:0048384 retinoic acid receptor signaling pathway 4/1036 30/18670 0.08219 0.4067 0.3591 CREM/NR2C1/RARA/AKR1C3 4 GO:0050690 regulation of defense response to virus by virus 4/1036 30/18670 0.08219 0.4067 0.3591 CD247/FYN/LCK/AP2B1 4 GO:0061157 mRNA destabilization 4/1036 30/18670 0.08219 0.4067 0.3591 ZFP36/HNRNPR/PUM1/KHSRP 4 GO:0090022 regulation of neutrophil chemotaxis 4/1036 30/18670 0.08219 0.4067 0.3591 C1QBP/DAPK2/IL23A/LBP 4 GO:0090200 positive regulation of release of cytochrome c from mitochondria 4/1036 30/18670 0.08219 0.4067 0.3591 MOAP1/DNM1L/PMAIP1/MFF 4 GO:0010823 negative regulation of mitochondrion organization 6/1036 55/18670 0.08311 0.4105 0.3625 FLCN/SLC25A5/DNM1L/PSMD10/VAT1/SLC35F6 6 GO:0043030 regulation of macrophage activation 6/1036 55/18670 0.08311 0.4105 0.3625 IL6/RORA/CTSC/CST7/TLR6/LBP 6 GO:0050729 positive regulation of inflammatory response 13/1036 153/18670 0.08343 0.4112 0.3631 IL6/IL1B/CTSC/IL12B/TNF/F12/TLR3/IL23A/PTGER4/TLR6/IL15/IL17B/LBP 13 GO:0014013 regulation of gliogenesis 11/1036 124/18670 0.08358 0.4112 0.3631 IL6/IL1B/PRKCH/DAAM2/PPP1CC/TNF/CXCR4/LRP1/SPINT1/LIF/GPR183 11 GO:0051054 positive regulation of DNA metabolic process 18/1036 228/18670 0.08405 0.4112 0.3631 PCNA/PARP1/MYC/IL6/CCT7/TNFSF13/PRKCQ/CCT2/WAS/MSH2/TBX21/ATR/MAPK3/TNKS/HNRNPA2B1/ATRX/CDC7/CBX8 18 GO:0006260 DNA replication 21/1036 274/18670 0.08415 0.4112 0.3631 PCNA/S100A11/TOPBP1/RBBP4/ORC3/ANKRD17/ORC2/NAP1L1/ATR/GMNN/CDK2AP1/FBXO5/RBBP7/ORC4/ATRX/RPA1/TERF1/DONSON/CDC7/MCM6/POLQ 21 GO:0030516 regulation of axon extension 9/1036 96/18670 0.08503 0.4112 0.3631 ARHGAP4/MAP2/LRP1/SEMA4G/SEMA3G/DBN1/DSCAM/NTN1/ADNP 9 GO:0032755 positive regulation of interleukin-6 production 9/1036 96/18670 0.08503 0.4112 0.3631 IL6/IL1B/TNF/IL36A/TLR3/XBP1/MBP/TLR6/LBP 9 GO:0090277 positive regulation of peptide hormone secretion 9/1036 96/18670 0.08503 0.4112 0.3631 CD38/ABAT/OXCT1/DYNLL1/LRP1/TRH/AIMP1/GHRHR/NMU 9 GO:1990823 response to leukemia inhibitory factor 9/1036 96/18670 0.08503 0.4112 0.3631 ARID5B/SLC25A5/BCLAF1/NFYB/XBP1/PCOLCE/PFKP/B3GNT2/SMARCA5 9 GO:1990830 cellular response to leukemia inhibitory factor 9/1036 96/18670 0.08503 0.4112 0.3631 ARID5B/SLC25A5/BCLAF1/NFYB/XBP1/PCOLCE/PFKP/B3GNT2/SMARCA5 9 GO:0002313 mature B cell differentiation involved in immune response 3/1036 19/18670 0.0851 0.4112 0.3631 ITM2A/XBP1/GPR183 3 GO:0006534 cysteine metabolic process 3/1036 19/18670 0.0851 0.4112 0.3631 GCLC/AHCY/CBS 3 GO:0015669 gas transport 3/1036 19/18670 0.0851 0.4112 0.3631 MYC/RHAG/IPCEF1 3 GO:0032303 regulation of icosanoid secretion 3/1036 19/18670 0.0851 0.4112 0.3631 IL1B/NTSR1/CYP4A11 3 GO:0034138 toll-like receptor 3 signaling pathway 3/1036 19/18670 0.0851 0.4112 0.3631 PTPN22/TLR3/RFTN1 3 GO:0046112 nucleobase biosynthetic process 3/1036 19/18670 0.0851 0.4112 0.3631 CMPK1/PRPS1/APRT 3 GO:0051131 chaperone-mediated protein complex assembly 3/1036 19/18670 0.0851 0.4112 0.3631 CCT2/THEG/HOPX 3 GO:0060438 trachea development 3/1036 19/18670 0.0851 0.4112 0.3631 TGFBR2/RARA/MAPK3 3 GO:0071243 cellular response to arsenic-containing substance 3/1036 19/18670 0.0851 0.4112 0.3631 ATF3/ZFAND1/DAXX 3 GO:0090670 RNA localization to Cajal body 3/1036 19/18670 0.0851 0.4112 0.3631 CCT7/CCT2/SHQ1 3 GO:0090671 telomerase RNA localization to Cajal body 3/1036 19/18670 0.0851 0.4112 0.3631 CCT7/CCT2/SHQ1 3 GO:0090672 telomerase RNA localization 3/1036 19/18670 0.0851 0.4112 0.3631 CCT7/CCT2/SHQ1 3 GO:0090685 RNA localization to nucleus 3/1036 19/18670 0.0851 0.4112 0.3631 CCT7/CCT2/SHQ1 3 GO:0098581 detection of external biotic stimulus 3/1036 19/18670 0.0851 0.4112 0.3631 TLR6/PGLYRP4/LBP 3 GO:1902644 tertiary alcohol metabolic process 3/1036 19/18670 0.0851 0.4112 0.3631 AKR7A2/AKR1B1/AKR1C3 3 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 17/1036 214/18670 0.0873 0.4211 0.3718 RCHY1/USP25/CTSC/LAMP3/PSMD14/PSMC2/GCLC/RBX1/RPS7/TRIB2/CSNK2A2/EDEM1/PSMD10/WAC/UBB/RPL11/UBE2J1 17 GO:2001020 regulation of response to DNA damage stimulus 17/1036 214/18670 0.0873 0.4211 0.3718 PCNA/PARP1/MYC/BCLAF1/CRY1/USP1/WAS/EEF1E1/ATR/PIAS4/DYRK3/FBXO5/PSMD10/DYRK1A/PMAIP1/CBX8/POLQ 17 GO:0000096 sulfur amino acid metabolic process 5/1036 43/18670 0.08811 0.4227 0.3732 ADO/MTR/GCLC/AHCY/CBS 5 GO:0000959 mitochondrial RNA metabolic process 5/1036 43/18670 0.08811 0.4227 0.3732 TFB2M/TRMT61B/CDK5RAP1/MTO1/TRMT5 5 GO:0034383 low-density lipoprotein particle clearance 5/1036 43/18670 0.08811 0.4227 0.3732 LIPA/LDLRAP1/NPC1/AP2B1/KHSRP 5 GO:0045429 positive regulation of nitric oxide biosynthetic process 5/1036 43/18670 0.08811 0.4227 0.3732 IFNG/IL1B/PTX3/TNF/TLR6 5 GO:0045773 positive regulation of axon extension 5/1036 43/18670 0.08811 0.4227 0.3732 LRP1/DBN1/DSCAM/NTN1/ADNP 5 GO:1904646 cellular response to amyloid-beta 5/1036 43/18670 0.08811 0.4227 0.3732 PARP1/ITGA4/FYN/LRP1/TLR6 5 GO:0006749 glutathione metabolic process 6/1036 56/18670 0.08895 0.4246 0.3749 OPLAH/GCLC/GLO1/GSTT2/SOD1/GSTA3 6 GO:0034508 centromere complex assembly 6/1036 56/18670 0.08895 0.4246 0.3749 ITGB3BP/RBBP4/NPM1/RBBP7/RNF4/SMARCA5 6 GO:0044784 metaphase/anaphase transition of cell cycle 6/1036 56/18670 0.08895 0.4246 0.3749 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0090183 regulation of kidney development 6/1036 56/18670 0.08895 0.4246 0.3749 MYC/FLCN/MAGED1/PRKX/LIF/SIX2 6 GO:0035023 regulation of Rho protein signal transduction 12/1036 140/18670 0.08907 0.4246 0.3749 ARHGEF3/SOS1/FLCN/GPR18/ARHGEF7/ARHGEF17/MYO9B/HEG1/LPAR6/ARHGEF28/P2RY10/BCR 12 GO:0097553 calcium ion transmembrane import into cytosol 12/1036 140/18670 0.08907 0.4246 0.3749 CXCL11/CLIC2/FYN/NTSR1/FAM155B/TRPM2/LCK/PLCB3/JPH3/MCOLN1/GRIN2D/ATG5 12 GO:0046470 phosphatidylcholine metabolic process 8/1036 83/18670 0.0891 0.4246 0.3749 CETP/PNPLA6/CSNK2A2/STARD7/PON1/ACSL3/GDPD3/PLA2G3 8 GO:0015908 fatty acid transport 9/1036 97/18670 0.08938 0.4246 0.3749 ABCD3/IL1B/NTSR1/ANXA1/ABCC4/ACSL3/PLA2G3/NCOR1/CYP4A11 9 GO:1902882 regulation of response to oxidative stress 9/1036 97/18670 0.08938 0.4246 0.3749 PARP1/SFPQ/SESN1/FYN/TNF/LANCL1/PDE8A/TLR6/SOD1 9 GO:1990868 response to chemokine 9/1036 97/18670 0.08938 0.4246 0.3749 CXCL11/CCL5/CCR3/CXCR6/CXCR4/RBM15/CCL11/CCL25/CCL23 9 GO:1990869 cellular response to chemokine 9/1036 97/18670 0.08938 0.4246 0.3749 CXCL11/CCL5/CCR3/CXCR6/CXCR4/RBM15/CCL11/CCL25/CCL23 9 GO:0002675 positive regulation of acute inflammatory response 4/1036 31/18670 0.09043 0.4284 0.3783 IL6/IL1B/TNF/F12 4 GO:0006363 termination of RNA polymerase I transcription 4/1036 31/18670 0.09043 0.4284 0.3783 POLR1B/GTF2H3/TBP/TAF1C 4 GO:0090659 walking behavior 4/1036 31/18670 0.09043 0.4284 0.3783 NPC1/GLRA1/TRH/EFNB3 4 GO:0007051 spindle organization 14/1036 170/18670 0.0907 0.4293 0.3791 KIF2A/TUBGCP2/AURKC/KIZ/NDC80/HAUS2/GOLGA8N/TNKS/CLASP1/FBXO5/ATRX/RNF4/NCOR1/PRC1 14 GO:0033077 T cell differentiation in thymus 7/1036 70/18670 0.09261 0.438 0.3868 SOS1/RASGRP1/BCL11B/STK11/SOD1/CD3E/ATG5 7 GO:0003279 cardiac septum development 10/1036 112/18670 0.0928 0.4381 0.3868 TGFBR2/ACVR1/TGFBR3/PARVA/RARA/RBM15/CITED2/HEG1/AP2B1/FZD2 10 GO:0031109 microtubule polymerization or depolymerization 10/1036 112/18670 0.0928 0.4381 0.3868 KIF2A/RANBP9/TUBGCP2/CKAP2/MAP2/RANGRF/CLASP1/FBXO5/DYRK1A/TERF1 10 GO:0007259 JAK-STAT cascade 13/1036 156/18670 0.09363 0.4411 0.3895 STAT4/CCL5/IL6/IFNG/CTR9/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 13 GO:0042129 regulation of T cell proliferation 13/1036 156/18670 0.09363 0.4411 0.3895 SOS1/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/ANXA1/IL23A/IL15/CD3E/CLC 13 GO:0031124 mRNA 3'-end processing 9/1036 98/18670 0.09384 0.4411 0.3895 CTR9/EIF4A3/PCF11/NUDT21/CSTF2T/PABPC1/CDC40/RBM8A/UPF3B 9 GO:0031341 regulation of cell killing 9/1036 98/18670 0.09384 0.4411 0.3895 SH2D1A/IFNG/IL12B/PRF1/CD1A/RASGRP1/IL23A/CD5L/PGLYRP4 9 GO:0050848 regulation of calcium-mediated signaling 9/1036 98/18670 0.09384 0.4411 0.3895 DYRK2/HINT1/TRAT1/P2RX5/CLIC2/ERBB3/TNF/JPH3/CD3E 9 GO:0007409 axonogenesis 33/1036 468/18670 0.09399 0.4412 0.3896 AUTS2/SOS1/RANBP9/ITGA4/PRKCQ/ARHGAP4/FYN/CXCR4/LHX3/BMPR1B/PLXNB2/ARTN/MAP2/LRP1/SEMA4G/CYFIP2/BCL11B/PIK3CA/MAPK3/SEMA3G/STK11/PDLIM7/DOK1/DBN1/DSCAM/NTN1/B3GNT2/ADNP/PIK3R1/EFNB3/CRMP1/GFRA4/FEZ1 33 GO:1903362 regulation of cellular protein catabolic process 19/1036 247/18670 0.09409 0.4412 0.3896 RCHY1/DACT1/USP25/CTSC/LAMP3/PSMD14/PSMC2/GCLC/RBX1/RPS7/TRIB2/CSNK2A2/LRP1/EDEM1/PSMD10/WAC/UBB/RPL11/UBE2J1 19 GO:0052547 regulation of peptidase activity 32/1036 452/18670 0.09412 0.4412 0.3896 MYC/MALT1/WFDC1/LAMP3/CTSD/PSMD14/P2RX1/CYCS/FYN/MICAL1/BIRC3/TNF/SIAH2/RECK/PSME4/CYFIP2/SPINT1/LCK/PEBP1/PCOLCE/MBP/HSPE1/MAPK3/CST7/TIMP2/TIMP4/CSN2/IGBP1/PMAIP1/RPS6KA3/RCN3/PSMA3 32 GO:0010965 regulation of mitotic sister chromatid separation 6/1036 57/18670 0.095 0.4412 0.3896 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0042743 hydrogen peroxide metabolic process 6/1036 57/18670 0.095 0.4412 0.3896 CAT/HP/FYN/NNT/PRDX6/SOD1 6 GO:0048008 platelet-derived growth factor receptor signaling pathway 6/1036 57/18670 0.095 0.4412 0.3896 ARID5B/CBLB/LRP1/PIK3C2A/PDGFRL/BCR 6 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 6/1036 57/18670 0.095 0.4412 0.3896 IFNG/IL1B/PTX3/TNF/HDAC4/TLR6 6 GO:0006195 purine nucleotide catabolic process 5/1036 44/18670 0.09511 0.4412 0.3896 HINT1/PDE4B/PDE8A/NUDT9/ACAT1 5 GO:0014047 glutamate secretion 5/1036 44/18670 0.09511 0.4412 0.3896 KMO/NTSR1/TRH/SLC38A2/SLC1A3 5 GO:0033046 negative regulation of sister chromatid segregation 5/1036 44/18670 0.09511 0.4412 0.3896 PSMG2/NDC80/TNKS/FBXO5/ATRX 5 GO:0034080 CENP-A containing nucleosome assembly 5/1036 44/18670 0.09511 0.4412 0.3896 ITGB3BP/RBBP4/NPM1/RBBP7/SMARCA5 5 GO:0061641 CENP-A containing chromatin organization 5/1036 44/18670 0.09511 0.4412 0.3896 ITGB3BP/RBBP4/NPM1/RBBP7/SMARCA5 5 GO:0061756 leukocyte adhesion to vascular endothelial cell 5/1036 44/18670 0.09511 0.4412 0.3896 MADCAM1/ITGA4/TNF/ELANE/CCL25 5 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 5/1036 44/18670 0.09511 0.4412 0.3896 SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 5 GO:1904407 positive regulation of nitric oxide metabolic process 5/1036 44/18670 0.09511 0.4412 0.3896 IFNG/IL1B/PTX3/TNF/TLR6 5 GO:0050920 regulation of chemotaxis 17/1036 217/18670 0.09607 0.4426 0.3909 CCL5/IL6/C1QBP/GPR18/CXCR4/DAPK2/ARTN/SEMA4G/IL23A/MAPK3/ELANE/SEMA3G/GPR183/DSCAM/FGF18/SLAMF8/LBP 17 GO:0016137 glycoside metabolic process 3/1036 20/18670 0.09617 0.4426 0.3909 AKR7A2/AKR1B1/AKR1C3 3 GO:0019373 epoxygenase P450 pathway 3/1036 20/18670 0.09617 0.4426 0.3909 CYP2C9/CYP4A11/CYP4F12 3 GO:0034104 negative regulation of tissue remodeling 3/1036 20/18670 0.09617 0.4426 0.3909 CD38/IL6/BCR 3 GO:0042474 middle ear morphogenesis 3/1036 20/18670 0.09617 0.4426 0.3909 INSIG1/PRKRA/SIX2 3 GO:0060216 definitive hemopoiesis 3/1036 20/18670 0.09617 0.4426 0.3909 TGFBR3/LYL1/BCR 3 GO:0090195 chemokine secretion 3/1036 20/18670 0.09617 0.4426 0.3909 TNF/LRP1/MBP 3 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3/1036 20/18670 0.09617 0.4426 0.3909 BTG2/ZFP36/PABPC1 3 GO:1903978 regulation of microglial cell activation 3/1036 20/18670 0.09617 0.4426 0.3909 IL6/CTSC/CST7 3 GO:0097305 response to alcohol 18/1036 233/18670 0.09807 0.4493 0.3967 PARP1/ABAT/TGFBR2/OXCT1/CAT/PSMD14/FYN/TGFBR3/FDX1/RARA/GLRA1/TRH/SPHK2/PTGER4/SPI1/AKR1C3/SOD1/ADAM15 18 GO:2001057 reactive nitrogen species metabolic process 8/1036 85/18670 0.09897 0.4493 0.3967 IFNG/IL1B/PTX3/RORA/TNF/TLR6/MARC1/KHSRP 8 GO:0042744 hydrogen peroxide catabolic process 4/1036 32/18670 0.09904 0.4493 0.3967 CAT/HP/NNT/PRDX6 4 GO:0050779 RNA destabilization 4/1036 32/18670 0.09904 0.4493 0.3967 ZFP36/HNRNPR/PUM1/KHSRP 4 GO:0051085 chaperone cofactor-dependent protein refolding 4/1036 32/18670 0.09904 0.4493 0.3967 HSPA9/DNAJB1/HSPE1/HSPA14 4 GO:0060317 cardiac epithelial to mesenchymal transition 4/1036 32/18670 0.09904 0.4493 0.3967 TGFBR2/ACVR1/TGFBR3/ADAM15 4 GO:2000778 positive regulation of interleukin-6 secretion 4/1036 32/18670 0.09904 0.4493 0.3967 IL1B/TNF/XBP1/MBP 4 GO:0007266 Rho protein signal transduction 16/1036 203/18670 0.09996 0.4493 0.3967 RHOH/ARHGEF3/SOS1/FLCN/GPR18/ARHGAP4/WAS/ARHGEF7/ARHGEF17/MYO9B/HEG1/LPAR6/ARHGEF28/NTN1/P2RY10/BCR 16 GO:0017001 antibiotic catabolic process 6/1036 58/18670 0.1013 0.4493 0.3967 CAT/HP/NNT/AKR1C3/ALDH3B1/PRDX6 6 GO:0051058 negative regulation of small GTPase mediated signal transduction 6/1036 58/18670 0.1013 0.4493 0.3967 FLCN/RASA1/CD2AP/TIMP2/HEG1/SH3BP1 6 GO:0042752 regulation of circadian rhythm 10/1036 114/18670 0.1014 0.4493 0.3967 CREM/SFPQ/RORA/PSPC1/MAGED1/CRY1/PPP1CC/SIAH2/GHRHR/NMU 10 GO:0019058 viral life cycle 24/1036 328/18670 0.1019 0.4493 0.3967 SLAMF1/CCL5/NUP107/PTX3/NUP37/LAMP3/NPC1/CXCR6/TNF/CXCR4/NUP205/PCBP1/RSAD2/NUP85/UBA52/PABPC1/APOBEC3G/VPS37B/FCN1/UBB/NUP160/EFNB3/NUP214/ATG5 24 GO:0016574 histone ubiquitination 5/1036 45/18670 0.1024 0.4493 0.3967 CTR9/SKP1/TRIM37/WAC/CBX8 5 GO:0048255 mRNA stabilization 5/1036 45/18670 0.1024 0.4493 0.3967 HNRNPA0/ZFP36/PAIP1/ELAVL1/PABPC1 5 GO:0051985 negative regulation of chromosome segregation 5/1036 45/18670 0.1024 0.4493 0.3967 PSMG2/NDC80/TNKS/FBXO5/ATRX 5 GO:0070316 regulation of G0 to G1 transition 5/1036 45/18670 0.1024 0.4493 0.3967 RBBP4/YAF2/UXT/RBBP7/CDC7 5 GO:0030072 peptide hormone secretion 19/1036 250/18670 0.1026 0.4493 0.3967 CD38/ABAT/CCL5/IL6/IFNG/IL1B/OXCT1/PASK/UBE2Q1/SLC25A5/DYNLL1/CHGA/TNF/ANXA1/LRP1/TRH/AIMP1/GHRHR/NMU 19 GO:0003149 membranous septum morphogenesis 2/1036 10/18670 0.103 0.4493 0.3967 TGFBR2/FZD2 2 GO:0006002 fructose 6-phosphate metabolic process 2/1036 10/18670 0.103 0.4493 0.3967 PFKP/GFPT1 2 GO:0006222 UMP biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 CMPK1/UCKL1 2 GO:0006569 tryptophan catabolic process 2/1036 10/18670 0.103 0.4493 0.3967 KMO/KYNU 2 GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process 2/1036 10/18670 0.103 0.4493 0.3967 CMPK1/UCKL1 2 GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 CMPK1/UCKL1 2 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 2/1036 10/18670 0.103 0.4493 0.3967 NCK1/NPM1 2 GO:0014049 positive regulation of glutamate secretion 2/1036 10/18670 0.103 0.4493 0.3967 KMO/NTSR1 2 GO:0015937 coenzyme A biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 PPCS/ACAT1 2 GO:0016559 peroxisome fission 2/1036 10/18670 0.103 0.4493 0.3967 DNM1L/MFF 2 GO:0021694 cerebellar Purkinje cell layer formation 2/1036 10/18670 0.103 0.4493 0.3967 RORA/HERC1 2 GO:0030388 fructose 1,6-bisphosphate metabolic process 2/1036 10/18670 0.103 0.4493 0.3967 IFNG/PFKP 2 GO:0033131 regulation of glucokinase activity 2/1036 10/18670 0.103 0.4493 0.3967 DUSP12/COX11 2 GO:0033314 mitotic DNA replication checkpoint 2/1036 10/18670 0.103 0.4493 0.3967 NAE1/TOPBP1 2 GO:0033483 gas homeostasis 2/1036 10/18670 0.103 0.4493 0.3967 NNT/ADNP 2 GO:0035520 monoubiquitinated protein deubiquitination 2/1036 10/18670 0.103 0.4493 0.3967 USP16/USP1 2 GO:0035878 nail development 2/1036 10/18670 0.103 0.4493 0.3967 ITGA6/ITGB4 2 GO:0042436 indole-containing compound catabolic process 2/1036 10/18670 0.103 0.4493 0.3967 KMO/KYNU 2 GO:0043379 memory T cell differentiation 2/1036 10/18670 0.103 0.4493 0.3967 IL12B/IL23A 2 GO:0043653 mitochondrial fragmentation involved in apoptotic process 2/1036 10/18670 0.103 0.4493 0.3967 DNM1L/MFF 2 GO:0044359 modulation of molecular function in other organism 2/1036 10/18670 0.103 0.4493 0.3967 PTX3/RAB9A 2 GO:0045348 positive regulation of MHC class II biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 IFNG/XBP1 2 GO:0045945 positive regulation of transcription by RNA polymerase III 2/1036 10/18670 0.103 0.4493 0.3967 ICE1/ICE2 2 GO:0046049 UMP metabolic process 2/1036 10/18670 0.103 0.4493 0.3967 CMPK1/UCKL1 2 GO:0046218 indolalkylamine catabolic process 2/1036 10/18670 0.103 0.4493 0.3967 KMO/KYNU 2 GO:0048262 determination of dorsal/ventral asymmetry 2/1036 10/18670 0.103 0.4493 0.3967 AIDA/ACVR1 2 GO:0048304 positive regulation of isotype switching to IgG isotypes 2/1036 10/18670 0.103 0.4493 0.3967 MSH2/TBX21 2 GO:0051133 regulation of NK T cell activation 2/1036 10/18670 0.103 0.4493 0.3967 IL12B/IL23A 2 GO:0051231 spindle elongation 2/1036 10/18670 0.103 0.4493 0.3967 AURKC/PRC1 2 GO:0051409 response to nitrosative stress 2/1036 10/18670 0.103 0.4493 0.3967 GCLC/ATG5 2 GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction 2/1036 10/18670 0.103 0.4493 0.3967 PTX3/RAB9A 2 GO:0060033 anatomical structure regression 2/1036 10/18670 0.103 0.4493 0.3967 SPI1/AMHR2 2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum 2/1036 10/18670 0.103 0.4493 0.3967 INSIG1/UBE2J1 2 GO:0070942 neutrophil mediated cytotoxicity 2/1036 10/18670 0.103 0.4493 0.3967 ELANE/CTSG 2 GO:0090154 positive regulation of sphingolipid biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 TNF/SPHK2 2 GO:0090715 immunological memory formation process 2/1036 10/18670 0.103 0.4493 0.3967 IL12B/IL23A 2 GO:1900222 negative regulation of amyloid-beta clearance 2/1036 10/18670 0.103 0.4493 0.3967 IFNG/TNF 2 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/1036 10/18670 0.103 0.4493 0.3967 NCK1/PMAIP1 2 GO:1902513 regulation of organelle transport along microtubule 2/1036 10/18670 0.103 0.4493 0.3967 MAP2/FEZ1 2 GO:1903405 protein localization to nuclear body 2/1036 10/18670 0.103 0.4493 0.3967 CCT7/CCT2 2 GO:1904851 positive regulation of establishment of protein localization to telomere 2/1036 10/18670 0.103 0.4493 0.3967 CCT7/CCT2 2 GO:1904867 protein localization to Cajal body 2/1036 10/18670 0.103 0.4493 0.3967 CCT7/CCT2 2 GO:2000035 regulation of stem cell division 2/1036 10/18670 0.103 0.4493 0.3967 LBH/NCOA3 2 GO:2000252 negative regulation of feeding behavior 2/1036 10/18670 0.103 0.4493 0.3967 TRH/NMU 2 GO:2000304 positive regulation of ceramide biosynthetic process 2/1036 10/18670 0.103 0.4493 0.3967 TNF/SPHK2 2 GO:2000574 regulation of microtubule motor activity 2/1036 10/18670 0.103 0.4493 0.3967 DYNLL1/MAP2 2 GO:2001225 regulation of chloride transport 2/1036 10/18670 0.103 0.4493 0.3967 ABCB1/CA7 2 GO:0006305 DNA alkylation 7/1036 72/18670 0.1038 0.4506 0.3979 PARP1/MYC/GNAS/PIK3CA/SPI1/ATRX/METTL4 7 GO:0006306 DNA methylation 7/1036 72/18670 0.1038 0.4506 0.3979 PARP1/MYC/GNAS/PIK3CA/SPI1/ATRX/METTL4 7 GO:0051881 regulation of mitochondrial membrane potential 7/1036 72/18670 0.1038 0.4506 0.3979 PARP1/GCLC/NNT/UBB/PMAIP1/SOD1/NDUFS1 7 GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 7/1036 72/18670 0.1038 0.4506 0.3979 USP25/LAMP3/RPS7/CSNK2A2/WAC/RPL11/UBE2J1 7 GO:0046883 regulation of hormone secretion 20/1036 266/18670 0.104 0.4506 0.3979 CD38/ABAT/CCL5/IFNG/IL1B/OXCT1/PASK/GNAS/SLC25A5/DYNLL1/CHGA/CRY1/TNF/ANXA1/LRP1/TRH/LIF/AIMP1/GHRHR/NMU 20 GO:0009755 hormone-mediated signaling pathway 18/1036 235/18670 0.1041 0.4506 0.3979 LBH/PARP1/TRIM68/NR3C2/RORA/NR2C1/CRY1/RWDD1/PHB2/NCOA3/RARA/TRH/GHRHR/KDM5D/DAXX/RNF4/NCOR1/ZBTB7A 18 GO:0030101 natural killer cell activation 8/1036 86/18670 0.1041 0.4506 0.3979 CD2/IL12B/CD244/PTPN22/RASGRP1/IL23A/IL15/PGLYRP4 8 GO:0032760 positive regulation of tumor necrosis factor production 8/1036 86/18670 0.1041 0.4506 0.3979 IFNG/CD2/IL12B/RASGRP1/TLR3/IL23A/PIK3R1/LBP 8 GO:0042446 hormone biosynthetic process 8/1036 86/18670 0.1041 0.4506 0.3979 NFKB1/IFNG/IL1B/HSD11B2/TNF/FDX1/AKR1B1/AKR1C3 8 GO:0048013 ephrin receptor signaling pathway 8/1036 86/18670 0.1041 0.4506 0.3979 NCK1/RASA1/FYN/ARHGEF7/APH1B/ARHGEF28/AP2B1/EFNB3 8 GO:0043687 post-translational protein modification 26/1036 361/18670 0.1051 0.4543 0.4012 NAE1/IL6/FLCN/SKP1/FBXO21/PSMA2/PSMA5/PSMD14/COPS4/PSMA1/PSMC2/RBX1/PSME4/FBXW12/PSMD12/AMBN/PSMB1/ZBTB16/ASB7/RBBP7/PSMD10/CUL1/TULP4/PSMC5/PSMA3/ATG5 26 GO:1904375 regulation of protein localization to cell periphery 10/1036 115/18670 0.1058 0.4573 0.4038 IFNG/PRKCH/LDLRAP1/TNF/LRP1/STX8/ANXA13/RANGRF/ACSL3/PIK3R1 10 GO:0097164 ammonium ion metabolic process 16/1036 205/18670 0.1065 0.4592 0.4055 ABAT/CETP/ODC1/PNPLA6/ACADM/CSNK2A2/STARD7/AKR7A2/TRH/SPHK2/PON1/AKR1B1/AKR1C3/ACSL3/GDPD3/PLA2G3 16 GO:0008033 tRNA processing 11/1036 130/18670 0.1074 0.4592 0.4055 SEPHS1/TARBP1/TRMT61B/POLR3K/DDX1/CDK5RAP1/THUMPD1/MTO1/TRMT5/TRMT112/TPRKB 11 GO:0061077 chaperone-mediated protein folding 6/1036 59/18670 0.1078 0.4592 0.4055 HSPA9/HSPB6/CCT2/DNAJB1/HSPE1/HSPA14 6 GO:0001779 natural killer cell differentiation 3/1036 21/18670 0.1078 0.4592 0.4055 RASGRP1/IL15/PGLYRP4 3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 3/1036 21/18670 0.1078 0.4592 0.4055 CYCS/COX6C/NDUFA4 3 GO:0010310 regulation of hydrogen peroxide metabolic process 3/1036 21/18670 0.1078 0.4592 0.4055 HP/FYN/NNT 3 GO:0010893 positive regulation of steroid biosynthetic process 3/1036 21/18670 0.1078 0.4592 0.4055 IFNG/IL1B/TNF 3 GO:0019646 aerobic electron transport chain 3/1036 21/18670 0.1078 0.4592 0.4055 CYCS/COX6C/NDUFA4 3 GO:0032332 positive regulation of chondrocyte differentiation 3/1036 21/18670 0.1078 0.4592 0.4055 BMPR1B/ZBTB16/FGF18 3 GO:0045061 thymic T cell selection 3/1036 21/18670 0.1078 0.4592 0.4055 STK11/CD3E/ATG5 3 GO:0051383 kinetochore organization 3/1036 21/18670 0.1078 0.4592 0.4055 NDC80/RNF4/SMC2 3 GO:0070584 mitochondrion morphogenesis 3/1036 21/18670 0.1078 0.4592 0.4055 DNM1L/MFF/FEZ1 3 GO:0098743 cell aggregation 3/1036 21/18670 0.1078 0.4592 0.4055 BMPR1B/MPZ/OTOR 3 GO:1903055 positive regulation of extracellular matrix organization 3/1036 21/18670 0.1078 0.4592 0.4055 IL6/CLASP1/COLGALT1 3 GO:0009303 rRNA transcription 4/1036 33/18670 0.108 0.4592 0.4055 GTF3C3/NOL11/POLR1B/GTF3A 4 GO:0016242 negative regulation of macroautophagy 4/1036 33/18670 0.108 0.4592 0.4055 NPC1/SCFD1/PIK3CA/FEZ1 4 GO:0018279 protein N-linked glycosylation via asparagine 4/1036 33/18670 0.108 0.4592 0.4055 ASGR2/ASGR1/MGAT2/UBE2J1 4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4/1036 33/18670 0.108 0.4592 0.4055 DCP1A/EXOSC8/TTC37/LSM2 4 GO:0048661 positive regulation of smooth muscle cell proliferation 9/1036 101/18670 0.108 0.4592 0.4055 CCL5/IL6/TGFBR2/LDLRAP1/TNF/ELANE/HDAC4/AKR1B1/ABCC4 9 GO:1903426 regulation of reactive oxygen species biosynthetic process 9/1036 101/18670 0.108 0.4592 0.4055 IFNG/IL1B/PTX3/FYN/TNF/SPHK2/HDAC4/TLR6/KHSRP 9 GO:0006334 nucleosome assembly 12/1036 145/18670 0.1082 0.4593 0.4056 ITGB3BP/HAT1/RBBP4/SART3/HIRA/NAP1L1/NPM1/TSPY1/RBBP7/DAXX/ATRX/SMARCA5 12 GO:0007612 learning 12/1036 145/18670 0.1082 0.4593 0.4056 DDHD2/EIF4A3/BTG2/VDAC3/FYN/NTSR1/SLC12A5/ATP8A1/HRH2/SLC8A2/PRKAR2B/JPH3 12 GO:0006112 energy reserve metabolic process 8/1036 87/18670 0.1094 0.4631 0.409 DYRK2/MYC/PASK/GNAS/UGP2/PPP1CC/PHKG1/GFPT1 8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 8/1036 87/18670 0.1094 0.4631 0.409 CCL5/CAT/FYN/ERBB3/TNF/PIK3CA/HAX1/PIK3R1 8 GO:0009988 cell-cell recognition 7/1036 73/18670 0.1096 0.4631 0.409 FOLR3/CCT7/PRF1/CCT2/CD9/PCDHB6/CATSPERG 7 GO:1903524 positive regulation of blood circulation 7/1036 73/18670 0.1096 0.4631 0.409 CD38/ATP2A2/CHGA/HRH2/AVPR1B/KCNQ1/NMU 7 GO:0031334 positive regulation of protein complex assembly 20/1036 268/18670 0.1098 0.4631 0.409 PARP1/IFNG/NCK1/PSMC2/BCLAF1/TNF/RBX1/WAS/GTF2H3/ATR/ICE1/CCL11/CLASP1/TLR6/ATAT1/SETX/PMAIP1/RPA1/TERF1/PSMC5 20 GO:0006984 ER-nucleus signaling pathway 5/1036 46/18670 0.1099 0.4631 0.409 NCK1/INSIG1/ATP2A2/ATF3/XBP1 5 GO:0032527 protein exit from endoplasmic reticulum 5/1036 46/18670 0.1099 0.4631 0.409 INSIG1/DERL1/EDEM1/RANGRF/UBE2J1 5 GO:0051646 mitochondrion localization 5/1036 46/18670 0.1099 0.4631 0.409 MFN1/DNM1L/UXT/UBB/FEZ1 5 GO:0060443 mammary gland morphogenesis 5/1036 46/18670 0.1099 0.4631 0.409 TGFBR2/CAPN1/PHB2/CCL11/NTN1 5 GO:0018108 peptidyl-tyrosine phosphorylation 26/1036 363/18670 0.1101 0.4631 0.409 DYRK2/CCL5/IL6/IFNG/IL12B/CBLB/ACVR1/FYN/ERBB3/TNF/TXK/ITK/CLK2/LCK/IL23A/MAPK3/LIF/DYRK3/IL15/DYRK1A/HAX1/ROR1/CD3E/ADNP/IL3/NCAPG2 26 GO:0030111 regulation of Wnt signaling pathway 26/1036 363/18670 0.1101 0.4631 0.409 NFKB1/DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/RBX1/RECK/CAPRIN2/PSME4/PSMD12/LRP1/MLLT3/SULF1/CMAHP/HMGXB4/TNKS/PSMB1/BICC1/STK11/PSMD10/PSMC5/PSMA3 26 GO:0010970 transport along microtubule 13/1036 161/18670 0.1123 0.4716 0.4165 SFPQ/IFT22/DYNLL1/HSPB11/KIFAP3/MAP2/RASGRP1/UXT/FYCO1/PCM1/UBB/SOD1/FEZ1 13 GO:0099111 microtubule-based transport 13/1036 161/18670 0.1123 0.4716 0.4165 SFPQ/IFT22/DYNLL1/HSPB11/KIFAP3/MAP2/RASGRP1/UXT/FYCO1/PCM1/UBB/SOD1/FEZ1 13 GO:0043491 protein kinase B signaling 20/1036 269/18670 0.1128 0.4733 0.418 CCL5/IL1B/TRAT1/C1QBP/FLCN/PPP2R5C/RRAS/ICOS/FYN/ERBB3/TNF/LCK/PIK3CA/STK11/AKR1C3/SETX/HAX1/FGF18/PIK3R1/RCN3 20 GO:0051306 mitotic sister chromatid separation 6/1036 60/18670 0.1145 0.4774 0.4216 CDC23/ANAPC5/PSMG2/NDC80/RIOK2/FBXO5 6 GO:0051784 negative regulation of nuclear division 6/1036 60/18670 0.1145 0.4774 0.4216 PSMG2/NDC80/LIF/TNKS/FBXO5/ATRX 6 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 6/1036 60/18670 0.1145 0.4774 0.4216 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0044272 sulfur compound biosynthetic process 15/1036 192/18670 0.1145 0.4774 0.4216 SLC35D1/OPLAH/DLD/CHST12/MTR/PDHX/GCLC/PPCS/CHPF2/CBS/ACSL3/PDHB/B3GNT2/GSTA3/ACAT1 15 GO:0043044 ATP-dependent chromatin remodeling 8/1036 88/18670 0.1149 0.4774 0.4216 ITGB3BP/ACTR6/RBBP4/PSME4/NPM1/RBBP7/ZNHIT1/SMARCA5 8 GO:1900407 regulation of cellular response to oxidative stress 8/1036 88/18670 0.1149 0.4774 0.4216 PARP1/SFPQ/FYN/TNF/LANCL1/PDE8A/TLR6/SOD1 8 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 8/1036 88/18670 0.1149 0.4774 0.4216 IFNG/CD2/IL12B/RASGRP1/TLR3/IL23A/PIK3R1/LBP 8 GO:1901222 regulation of NIK/NF-kappaB signaling 10/1036 117/18670 0.1151 0.4774 0.4216 IL1B/NR3C2/MALT1/IL12B/TNF/PTPN22/TRIM44/TLR3/IL23A/TLR6 10 GO:0045137 development of primary sexual characteristics 17/1036 223/18670 0.1152 0.4774 0.4216 ARID5B/NUP107/PTX3/BMPR1B/MSH2/TLR3/CBX2/RARA/TSPY1/CITED2/AKR1C3/AMHR2/SRY/UBB/SOD1/ATRX/ADAM15 17 GO:0031670 cellular response to nutrient 7/1036 74/18670 0.1156 0.4774 0.4216 FYN/XBP1/USF2/TNKS/IL15/SOD1/TRIM24 7 GO:1903036 positive regulation of response to wounding 7/1036 74/18670 0.1156 0.4774 0.4216 TGFBR2/ENPP4/F12/CXCR4/ANXA1/LRP1/XBP1 7 GO:0045598 regulation of fat cell differentiation 11/1036 132/18670 0.1162 0.4774 0.4216 IL6/RORA/INSIG1/ZFP36/TNF/TRIB2/MEX3C/XBP1/ASXL2/ZBTB16/ATAT1 11 GO:0000723 telomere maintenance 13/1036 162/18670 0.1162 0.4774 0.4216 PCNA/PARP1/MYC/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/ATRX/RPA1/TERF1 13 GO:0002262 myeloid cell homeostasis 12/1036 147/18670 0.1165 0.4774 0.4216 IL6/HSPA9/ZFP36/PDE4B/TGFBR3/ANXA1/DYRK3/SPI1/SOD1/RHAG/NCAPG2/ZBTB7A 12 GO:0043524 negative regulation of neuron apoptotic process 12/1036 147/18670 0.1165 0.4774 0.4216 RASA1/BTG2/GCLC/FYN/ERBB3/MSH2/LRP1/PIK3CA/GABRB2/SOD1/ADNP/XRCC2 12 GO:0007623 circadian rhythm 16/1036 208/18670 0.1168 0.4774 0.4216 CREM/SFPQ/RORA/PSPC1/MAGED1/CRY1/PPP1CC/SIAH2/HNRNPR/AHCY/GHRHR/DYRK1A/SETX/NMU/NCOR1/GFPT1 16 GO:0050670 regulation of lymphocyte proliferation 16/1036 208/18670 0.1168 0.4774 0.4216 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/CLC 16 GO:0090276 regulation of peptide hormone secretion 16/1036 208/18670 0.1168 0.4774 0.4216 CD38/ABAT/CCL5/IFNG/IL1B/OXCT1/PASK/SLC25A5/DYNLL1/CHGA/TNF/LRP1/TRH/AIMP1/GHRHR/NMU 16 GO:0009164 nucleoside catabolic process 4/1036 34/18670 0.1173 0.4774 0.4216 DERA/ENPP4/AHCY/APOBEC3G 4 GO:0018196 peptidyl-asparagine modification 4/1036 34/18670 0.1173 0.4774 0.4216 ASGR2/ASGR1/MGAT2/UBE2J1 4 GO:0098664 G protein-coupled serotonin receptor signaling pathway 4/1036 34/18670 0.1173 0.4774 0.4216 CHRM5/HRH2/OR10H1/CHRM2 4 GO:0045023 G0 to G1 transition 5/1036 47/18670 0.1177 0.4774 0.4216 RBBP4/YAF2/UXT/RBBP7/CDC7 5 GO:0032091 negative regulation of protein binding 9/1036 103/18670 0.1181 0.4774 0.4216 DACT1/ITGA4/IFIT2/MAP2/MAPK3/ADAM15/ADNP/CCL23/CRMP1 9 GO:1902106 negative regulation of leukocyte differentiation 9/1036 103/18670 0.1181 0.4774 0.4216 MYC/ANXA1/TBX21/TLR3/RARA/LILRB3/LILRB4/PIK3R1/PGLYRP4 9 GO:0002683 negative regulation of immune system process 32/1036 463/18670 0.1182 0.4774 0.4216 CD96/MYC/GPR171/CTR9/C1QBP/GPR18/HSPA9/IL12B/PSMA1/ZFP36/HTRA1/TNF/PTPN22/HLA-DOB/ANXA1/TBX21/TLR3/RARA/LILRB3/CST7/RBM15/PTGER4/TLR6/ZBTB16/CCL25/LILRB4/SLAMF8/PIK3R1/PGLYRP4/GPATCH3/BCR/NCAPG2 32 GO:0006914 autophagy 34/1036 496/18670 0.1192 0.4774 0.4216 OPTN/IFNG/ATG14/LGALS8/FLCN/LAMP3/CAPN1/NPC1/SESN1/TOLLIP/DYNLL1/SCFD1/HERC1/PTPN22/MFN1/DAPK2/CSNK2A2/DNM1L/XBP1/EXOC7/PIK3CA/MAPK3/FYCO1/STK11/VPS51/VPS37B/ITGB4/TOMM20/WAC/HAX1/MCOLN1/KAT8/ATG5/FEZ1 34 GO:0061919 process utilizing autophagic mechanism 34/1036 496/18670 0.1192 0.4774 0.4216 OPTN/IFNG/ATG14/LGALS8/FLCN/LAMP3/CAPN1/NPC1/SESN1/TOLLIP/DYNLL1/SCFD1/HERC1/PTPN22/MFN1/DAPK2/CSNK2A2/DNM1L/XBP1/EXOC7/PIK3CA/MAPK3/FYCO1/STK11/VPS51/VPS37B/ITGB4/TOMM20/WAC/HAX1/MCOLN1/KAT8/ATG5/FEZ1 34 GO:0000469 cleavage involved in rRNA processing 3/1036 22/18670 0.1199 0.4774 0.4216 EXOSC8/RRS1/RPS21 3 GO:0006379 mRNA cleavage 3/1036 22/18670 0.1199 0.4774 0.4216 PCF11/NUDT21/CSTF2T 3 GO:0006925 inflammatory cell apoptotic process 3/1036 22/18670 0.1199 0.4774 0.4216 CCL5/IL6/ANXA1 3 GO:0007063 regulation of sister chromatid cohesion 3/1036 22/18670 0.1199 0.4774 0.4216 SFPQ/TNKS/ATRX 3 GO:0009235 cobalamin metabolic process 3/1036 22/18670 0.1199 0.4774 0.4216 MTR/LMBRD1/TCN2 3 GO:0016226 iron-sulfur cluster assembly 3/1036 22/18670 0.1199 0.4774 0.4216 ISCA1/NFU1/HSPA9 3 GO:0031163 metallo-sulfur cluster assembly 3/1036 22/18670 0.1199 0.4774 0.4216 ISCA1/NFU1/HSPA9 3 GO:0034643 establishment of mitochondrion localization, microtubule-mediated 3/1036 22/18670 0.1199 0.4774 0.4216 UXT/UBB/FEZ1 3 GO:0046599 regulation of centriole replication 3/1036 22/18670 0.1199 0.4774 0.4216 TRIM37/NPM1/CEP76 3 GO:0047497 mitochondrion transport along microtubule 3/1036 22/18670 0.1199 0.4774 0.4216 UXT/UBB/FEZ1 3 GO:0051195 negative regulation of cofactor metabolic process 3/1036 22/18670 0.1199 0.4774 0.4216 HP/FYN/HDAC4 3 GO:0051457 maintenance of protein location in nucleus 3/1036 22/18670 0.1199 0.4774 0.4216 SKP1/SUPT7L/SYNE1 3 GO:0070935 3'-UTR-mediated mRNA stabilization 3/1036 22/18670 0.1199 0.4774 0.4216 HNRNPA0/ZFP36/ELAVL1 3 GO:0090312 positive regulation of protein deacetylation 3/1036 22/18670 0.1199 0.4774 0.4216 IFNG/FNTA/DYRK1A 3 GO:0050663 cytokine secretion 18/1036 240/18670 0.12 0.4774 0.4216 IL1A/IFNG/CD2/IL1B/CD244/TNF/PTPN22/ANXA1/LRP1/RASGRP1/XBP1/MBP/MAPK3/SPHK2/PTGER4/TLR6/FCN1/ATG5 18 GO:0032944 regulation of mononuclear cell proliferation 16/1036 209/18670 0.1204 0.4774 0.4216 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/CLC 16 GO:0007265 Ras protein signal transduction 31/1036 448/18670 0.1212 0.4774 0.4216 RHOH/AUTS2/ARHGEF3/SOS1/FLCN/GPR18/RASA1/RRAS/RAPGEF6/IFT22/ARHGAP4/WAS/RASGRP1/ARHGEF7/ARHGEF17/MYO9B/RAB9A/RRAS2/TIMP2/RABL3/RANGRF/DOK1/HEG1/LPAR6/ARHGEF28/NTN1/IQSEC3/P2RY10/RAB36/DOK3/BCR 31 GO:0046513 ceramide biosynthetic process 6/1036 61/18670 0.1214 0.4774 0.4216 ST3GAL5/P2RX1/TNF/CERS6/SPHK2/AGK 6 GO:0090303 positive regulation of wound healing 6/1036 61/18670 0.1214 0.4774 0.4216 TGFBR2/ENPP4/F12/CXCR4/ANXA1/XBP1 6 GO:0000478 endonucleolytic cleavage involved in rRNA processing 2/1036 11/18670 0.1214 0.4774 0.4216 RRS1/RPS21 2 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/1036 11/18670 0.1214 0.4774 0.4216 RRS1/RPS21 2 GO:0000727 double-strand break repair via break-induced replication 2/1036 11/18670 0.1214 0.4774 0.4216 CDC7/MCM6 2 GO:0001731 formation of translation preinitiation complex 2/1036 11/18670 0.1214 0.4774 0.4216 EIF4B/EIF5 2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process 2/1036 11/18670 0.1214 0.4774 0.4216 UAP1L1/GFPT1 2 GO:0008655 pyrimidine-containing compound salvage 2/1036 11/18670 0.1214 0.4774 0.4216 DCK/UCKL1 2 GO:0009113 purine nucleobase biosynthetic process 2/1036 11/18670 0.1214 0.4774 0.4216 PRPS1/APRT 2 GO:0014820 tonic smooth muscle contraction 2/1036 11/18670 0.1214 0.4774 0.4216 CD38/NMU 2 GO:0014883 transition between fast and slow fiber 2/1036 11/18670 0.1214 0.4774 0.4216 ATP2A2/TNNI1 2 GO:0019852 L-ascorbic acid metabolic process 2/1036 11/18670 0.1214 0.4774 0.4216 GCLC/CYB5A 2 GO:0030422 production of siRNA involved in RNA interference 2/1036 11/18670 0.1214 0.4774 0.4216 DROSHA/PRKRA 2 GO:0032351 negative regulation of hormone metabolic process 2/1036 11/18670 0.1214 0.4774 0.4216 NFKB1/AKR1C3 2 GO:0032377 regulation of intracellular lipid transport 2/1036 11/18670 0.1214 0.4774 0.4216 LDLRAP1/SCP2 2 GO:0032380 regulation of intracellular sterol transport 2/1036 11/18670 0.1214 0.4774 0.4216 LDLRAP1/SCP2 2 GO:0032383 regulation of intracellular cholesterol transport 2/1036 11/18670 0.1214 0.4774 0.4216 LDLRAP1/SCP2 2 GO:0032490 detection of molecule of bacterial origin 2/1036 11/18670 0.1214 0.4774 0.4216 TLR6/LBP 2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2/1036 11/18670 0.1214 0.4774 0.4216 ACADM/ETFA 2 GO:0033632 regulation of cell-cell adhesion mediated by integrin 2/1036 11/18670 0.1214 0.4774 0.4216 CCL5/CD3E 2 GO:0035404 histone-serine phosphorylation 2/1036 11/18670 0.1214 0.4774 0.4216 AURKC/VRK1 2 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 2/1036 11/18670 0.1214 0.4774 0.4216 C1QBP/GPATCH3 2 GO:0043097 pyrimidine nucleoside salvage 2/1036 11/18670 0.1214 0.4774 0.4216 DCK/UCKL1 2 GO:0045060 negative thymic T cell selection 2/1036 11/18670 0.1214 0.4774 0.4216 CD3E/ATG5 2 GO:0045628 regulation of T-helper 2 cell differentiation 2/1036 11/18670 0.1214 0.4774 0.4216 ANXA1/RARA 2 GO:0045835 negative regulation of meiotic nuclear division 2/1036 11/18670 0.1214 0.4774 0.4216 LIF/FBXO5 2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly 2/1036 11/18670 0.1214 0.4774 0.4216 PSMC2/PSMC5 2 GO:0045919 positive regulation of cytolysis 2/1036 11/18670 0.1214 0.4774 0.4216 PGLYRP4/LBP 2 GO:0046439 L-cysteine metabolic process 2/1036 11/18670 0.1214 0.4774 0.4216 AHCY/CBS 2 GO:0051024 positive regulation of immunoglobulin secretion 2/1036 11/18670 0.1214 0.4774 0.4216 IL6/XBP1 2 GO:0055091 phospholipid homeostasis 2/1036 11/18670 0.1214 0.4774 0.4216 CETP/RCN3 2 GO:0060439 trachea morphogenesis 2/1036 11/18670 0.1214 0.4774 0.4216 TGFBR2/MAPK3 2 GO:0070189 kynurenine metabolic process 2/1036 11/18670 0.1214 0.4774 0.4216 KMO/KYNU 2 GO:0070475 rRNA base methylation 2/1036 11/18670 0.1214 0.4774 0.4216 EMG1/TRMT112 2 GO:0090042 tubulin deacetylation 2/1036 11/18670 0.1214 0.4774 0.4216 BEX4/FNTA 2 GO:0090084 negative regulation of inclusion body assembly 2/1036 11/18670 0.1214 0.4774 0.4216 SACS/DNAJB1 2 GO:1901077 regulation of relaxation of muscle 2/1036 11/18670 0.1214 0.4774 0.4216 CHGA/PDE4B 2 GO:1902065 response to L-glutamate 2/1036 11/18670 0.1214 0.4774 0.4216 PCNA/FYN 2 GO:1902805 positive regulation of synaptic vesicle transport 2/1036 11/18670 0.1214 0.4774 0.4216 MAP2/DNM1L 2 GO:1903299 regulation of hexokinase activity 2/1036 11/18670 0.1214 0.4774 0.4216 DUSP12/COX11 2 GO:1905941 positive regulation of gonad development 2/1036 11/18670 0.1214 0.4774 0.4216 CITED2/SRY 2 GO:2000767 positive regulation of cytoplasmic translation 2/1036 11/18670 0.1214 0.4774 0.4216 NCK1/CNBP 2 GO:0051090 regulation of DNA-binding transcription factor activity 30/1036 432/18670 0.1217 0.4776 0.4217 ARID5B/NFKB1/IL6/IL1B/PRKCH/MALT1/CAT/PRKCQ/CRTC3/GTF2A2/TRIM37/TNF/TRAF5/RWDD1/PHB2/PPRC1/TLR3/NPM1/PIAS4/MAPK3/UBA52/HDAC4/TLR6/PSMD10/UBB/ROR1/TAF12/FZD2/EDA2R/ZBTB7A 30 GO:0006695 cholesterol biosynthetic process 7/1036 75/18670 0.1218 0.4776 0.4217 IDI1/MSMO1/INSIG1/NFYB/SC5D/SOD1/CNBP 7 GO:0046173 polyol biosynthetic process 7/1036 75/18670 0.1218 0.4776 0.4217 CD244/NTSR1/PLCL1/QDPR/PLCB3/SPHK2/AKR1B1 7 GO:1903201 regulation of oxidative stress-induced cell death 7/1036 75/18670 0.1218 0.4776 0.4217 PARP1/SFPQ/FYN/LANCL1/PDE8A/TLR6/SOD1 7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 9/1036 104/18670 0.1233 0.4832 0.4267 IL1A/IL1B/ITGA6/GCLC/ACVR1/FYN/TNF/SIAH2/ZMYND11 9 GO:0048285 organelle fission 31/1036 449/18670 0.1236 0.4839 0.4273 MYBL1/DDHD2/IL1A/KIF2A/IL1B/AURKC/CDC23/CDC25B/ANAPC5/SLC25A46/USP16/ZWINT/PSMG2/TMEM135/HIRA/PHB2/DNM1L/NDC80/LIF/TNKS/RIOK2/CLASP1/FBXO5/RRS1/PKMYT1/UBB/ATRX/MFF/PRC1/TERF1/SMC2 31 GO:0006323 DNA packaging 16/1036 210/18670 0.124 0.485 0.4283 ITGB3BP/HAT1/RBBP4/SART3/HIRA/GATAD1/PSME4/NAP1L1/NPM1/TSPY1/RBBP7/DAXX/ATRX/NCAPG2/SMARCA5/SMC2 16 GO:0007006 mitochondrial membrane organization 11/1036 134/18670 0.1253 0.4896 0.4323 MOAP1/SLC25A5/GZMB/MFN1/YWHAQ/OXA1L/AGK/TOMM20/CHCHD3/PMAIP1/SLC35F6 11 GO:0002063 chondrocyte development 5/1036 48/18670 0.1258 0.4896 0.4323 TGFBR2/BMPR1B/MEX3C/SULF1/FGF18 5 GO:0007595 lactation 5/1036 48/18670 0.1258 0.4896 0.4323 XBP1/USF2/CSN2/GHRHR/APRT 5 GO:0009069 serine family amino acid metabolic process 5/1036 48/18670 0.1258 0.4896 0.4323 SLC25A32/SEPHS1/GCLC/AHCY/CBS 5 GO:0031055 chromatin remodeling at centromere 5/1036 48/18670 0.1258 0.4896 0.4323 ITGB3BP/RBBP4/NPM1/RBBP7/SMARCA5 5 GO:0045912 negative regulation of carbohydrate metabolic process 5/1036 48/18670 0.1258 0.4896 0.4323 PASK/CRY1/COX11/CLK2/HDAC4 5 GO:0090199 regulation of release of cytochrome c from mitochondria 5/1036 48/18670 0.1258 0.4896 0.4323 MOAP1/DNM1L/PSMD10/PMAIP1/MFF 5 GO:0031058 positive regulation of histone modification 8/1036 90/18670 0.1262 0.4909 0.4335 AUTS2/BRD7/CTR9/IL1B/SART3/MAPK3/LIF/SPHK2 8 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 4/1036 35/18670 0.127 0.4915 0.434 DCP1A/EXOSC8/TTC37/LSM2 4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4/1036 35/18670 0.127 0.4915 0.434 UTP3/RRS1/RPS21/PWP2 4 GO:0032689 negative regulation of interferon-gamma production 4/1036 35/18670 0.127 0.4915 0.434 CD96/C1QBP/RARA/PGLYRP4 4 GO:0032735 positive regulation of interleukin-12 production 4/1036 35/18670 0.127 0.4915 0.434 IFNG/IL12B/TLR3/IL23A 4 GO:0051354 negative regulation of oxidoreductase activity 4/1036 35/18670 0.127 0.4915 0.434 NFKB1/HP/GZMA/OXA1L 4 GO:0051954 positive regulation of amine transport 4/1036 35/18670 0.127 0.4915 0.434 ABAT/KMO/NTSR1/TRH 4 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 4/1036 35/18670 0.127 0.4915 0.434 BIRC3/PTPN22/UBA52/UBB 4 GO:0030705 cytoskeleton-dependent intracellular transport 14/1036 180/18670 0.1273 0.4923 0.4347 SFPQ/IFT22/CCDC88C/DYNLL1/HSPB11/KIFAP3/MAP2/RASGRP1/UXT/FYCO1/PCM1/UBB/SOD1/FEZ1 14 GO:0043254 regulation of protein complex assembly 32/1036 467/18670 0.1278 0.4939 0.4362 PARP1/IFNG/DACT1/NCK1/INSIG1/RASA1/ADD3/PSMC2/BCLAF1/TNF/RBX1/WAS/GTF2H3/MAP2/DNM1L/ATR/ICE1/RANGRF/CCL11/PTGER4/CLASP1/TLR6/DBN1/ATAT1/DYRK1A/SETX/PMAIP1/HAX1/RNF4/RPA1/TERF1/PSMC5 32 GO:1902653 secondary alcohol biosynthetic process 7/1036 76/18670 0.1281 0.4948 0.4369 IDI1/MSMO1/INSIG1/NFYB/SC5D/SOD1/CNBP 7 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 6/1036 62/18670 0.1284 0.4952 0.4373 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0002791 regulation of peptide secretion 34/1036 500/18670 0.1286 0.4952 0.4373 CD38/ABAT/IL1A/CCL5/IL6/IFNG/CD2/IL1B/OXCT1/PASK/SLC25A5/DYNLL1/CD244/CHGA/TNF/PTPN22/CD2AP/ANXA1/LRP1/RASGRP1/DNM1L/XBP1/MBP/RSAD2/TRH/MAPK3/AIMP1/PTGER4/TLR6/GHRHR/FCN1/NMU/SEC24A/ATG5 34 GO:0031497 chromatin assembly 13/1036 165/18670 0.1286 0.4952 0.4373 ITGB3BP/HAT1/RBBP4/SART3/HIRA/GATAD1/NAP1L1/NPM1/TSPY1/RBBP7/DAXX/ATRX/SMARCA5 13 GO:0050954 sensory perception of mechanical stimulus 13/1036 165/18670 0.1286 0.4952 0.4373 PIEZO2/FYN/CXCR4/LRIG1/MBP/GABRB2/ATP2B2/OTOR/SOD1/ROR1/KCNQ1/PGAP1/SLC1A3 13 GO:0071897 DNA biosynthetic process 15/1036 196/18670 0.1296 0.4987 0.4403 PCNA/MYC/RCHY1/CCT7/PRKCQ/CCT2/ATR/MAPK3/UBA52/TNKS/HNRNPA2B1/UBB/RPA1/TERF1/POLQ 15 GO:0002698 negative regulation of immune effector process 10/1036 120/18670 0.1298 0.4991 0.4407 CD96/C1QBP/HTRA1/TNF/ANXA1/TBX21/SLAMF8/PGLYRP4/GPATCH3/BCR 10 GO:0050921 positive regulation of chemotaxis 11/1036 135/18670 0.13 0.4996 0.4411 CCL5/IL6/C1QBP/CXCR4/DAPK2/ARTN/IL23A/MAPK3/DSCAM/FGF18/LBP 11 GO:0048871 multicellular organismal homeostasis 33/1036 485/18670 0.1319 0.5043 0.4454 CD38/ABAT/IL1A/IL6/IL1B/FLCN/LYZ/PASK/LIPA/GNAS/CRTC3/PRKACB/NTSR1/PLCL1/TNF/TRPM2/CXCR4/MUC2/MEX3C/PRKAR2B/PIK3CA/AKR1B1/STK11/FH/IL15/UBB/SOD1/RHAG/NMU/ZNF516/RCN3/CYP4A11/CYP4F12 33 GO:1901992 positive regulation of mitotic cell cycle phase transition 8/1036 91/18670 0.1321 0.5043 0.4454 CDC25B/ANAPC5/ANKRD17/ANXA1/PHB2/SMARCD3/FBXO5/CDC7 8 GO:0002347 response to tumor cell 3/1036 23/18670 0.1325 0.5043 0.4454 IL12B/PRF1/ADAM15 3 GO:0006359 regulation of transcription by RNA polymerase III 3/1036 23/18670 0.1325 0.5043 0.4454 ICE1/POLR3C/ICE2 3 GO:0009595 detection of biotic stimulus 3/1036 23/18670 0.1325 0.5043 0.4454 TLR6/PGLYRP4/LBP 3 GO:0015740 C4-dicarboxylate transport 3/1036 23/18670 0.1325 0.5043 0.4454 ABAT/NTSR1/SLC1A3 3 GO:0032753 positive regulation of interleukin-4 production 3/1036 23/18670 0.1325 0.5043 0.4454 PRKCQ/RARA/CD3E 3 GO:0042454 ribonucleoside catabolic process 3/1036 23/18670 0.1325 0.5043 0.4454 ENPP4/AHCY/APOBEC3G 3 GO:0044458 motile cilium assembly 3/1036 23/18670 0.1325 0.5043 0.4454 ATMIN/DYNLL1/ZMYND10 3 GO:0050995 negative regulation of lipid catabolic process 3/1036 23/18670 0.1325 0.5043 0.4454 IL1B/CRTC3/TNF 3 GO:0072337 modified amino acid transport 3/1036 23/18670 0.1325 0.5043 0.4454 FOLR3/SLC25A32/SLC38A2 3 GO:2000050 regulation of non-canonical Wnt signaling pathway 3/1036 23/18670 0.1325 0.5043 0.4454 DACT1/DAAM2/MLLT3 3 GO:2000637 positive regulation of gene silencing by miRNA 3/1036 23/18670 0.1325 0.5043 0.4454 ZFP36/PUM1/FXR1 3 GO:0097696 STAT cascade 13/1036 166/18670 0.1329 0.5056 0.4464 STAT4/CCL5/IL6/IFNG/CTR9/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 13 GO:0002686 negative regulation of leukocyte migration 5/1036 49/18670 0.1341 0.5089 0.4494 GPR18/PTGER4/CCL25/SLAMF8/BCR 5 GO:0051205 protein insertion into membrane 5/1036 49/18670 0.1341 0.5089 0.4494 MOAP1/GZMB/YWHAQ/OXA1L/PMAIP1 5 GO:0061912 selective autophagy 5/1036 49/18670 0.1341 0.5089 0.4494 OPTN/ATG14/LGALS8/MAPK3/ATG5 5 GO:0072659 protein localization to plasma membrane 19/1036 260/18670 0.1345 0.5096 0.45 OPTN/IFNG/PRKCH/RAPGEF6/LDLRAP1/TNF/GORASP2/EHD2/LRP1/STX8/EMP2/ATP1B1/ANXA13/RANGRF/C16orf70/EHD3/ACSL3/PIK3R1/TMED2 19 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 7/1036 77/18670 0.1347 0.5096 0.45 DCP1A/BTG2/ZFP36/EXOSC8/TTC37/PABPC1/LSM2 7 GO:0006809 nitric oxide biosynthetic process 7/1036 77/18670 0.1347 0.5096 0.45 IFNG/IL1B/PTX3/RORA/TNF/TLR6/KHSRP 7 GO:0008344 adult locomotory behavior 7/1036 77/18670 0.1347 0.5096 0.45 NPC1/NTSR1/PUM1/GLRA1/TRH/GRIN2D/EFNB3 7 GO:0048675 axon extension 10/1036 121/18670 0.1349 0.5103 0.4506 AUTS2/ARHGAP4/MAP2/LRP1/SEMA4G/SEMA3G/DBN1/DSCAM/NTN1/ADNP 10 GO:0002637 regulation of immunoglobulin production 6/1036 63/18670 0.1357 0.5119 0.452 IL6/TNFSF13/TNF/MSH2/TBX21/XBP1 6 GO:0032371 regulation of sterol transport 6/1036 63/18670 0.1357 0.5119 0.452 NFKB1/CETP/LDLRAP1/LRP1/SCP2/PON1 6 GO:0032374 regulation of cholesterol transport 6/1036 63/18670 0.1357 0.5119 0.452 NFKB1/CETP/LDLRAP1/LRP1/SCP2/PON1 6 GO:0045815 positive regulation of gene expression, epigenetic 6/1036 63/18670 0.1357 0.5119 0.452 POLR1B/DDX21/SPHK2/TBP/TAF1C/SMARCA5 6 GO:0043547 positive regulation of GTPase activity 28/1036 405/18670 0.136 0.5126 0.4526 SOS1/CCL5/FLCN/ARHGAP17/ITGA6/RASA1/RAPGEF6/ARHGAP4/RGS1/ADAP2/TBC1D2/RABGAP1L/RASGRP1/DNM1L/ARHGEF7/RIC8B/MYO9B/TBC1D4/RALGAPA1/ASAP2/CCL11/EIF5/CCL25/ZC3H15/TBC1D9/SH3BP1/CCL23/BCR 28 GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 4/1036 36/18670 0.137 0.5141 0.4539 BIRC3/PTPN22/UBA52/UBB 4 GO:1901099 negative regulation of signal transduction in absence of ligand 4/1036 36/18670 0.137 0.5141 0.4539 IL1A/IL1B/FYN/TNF 4 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/1036 36/18670 0.137 0.5141 0.4539 IL1A/IL1B/FYN/TNF 4 GO:1901568 fatty acid derivative metabolic process 13/1036 167/18670 0.1373 0.5141 0.4539 IL1B/OXCT1/ANXA1/MAPK3/PON1/CYP2C9/AKR1C3/ACSL3/PLA2G3/ACSS3/CYP4A11/ACAT1/CYP4F12 13 GO:2000117 negative regulation of cysteine-type endopeptidase activity 8/1036 92/18670 0.1381 0.5141 0.4539 LAMP3/MICAL1/BIRC3/SIAH2/CST7/CSN2/IGBP1/RPS6KA3 8 GO:0016051 carbohydrate biosynthetic process 16/1036 214/18670 0.1391 0.5141 0.4539 DYRK2/MDH1/NFKB1/PGK1/PASK/CHST12/CD244/UGP2/NTSR1/CRY1/ATF3/PHKG1/CLK2/AKR1B1/MGAT2/B3GNT2 16 GO:0030330 DNA damage response, signal transduction by p53 class mediator 9/1036 107/18670 0.1397 0.5141 0.4539 PCNA/BTG2/EEF1E1/ATR/DYRK3/PSMD10/DYRK1A/PMAIP1/ATRX 9 GO:0062014 negative regulation of small molecule metabolic process 9/1036 107/18670 0.1397 0.5141 0.4539 PARP1/NFKB1/FLCN/INSIG1/CRY1/CLK2/HDAC4/AKR1C3/SOD1 9 GO:0061136 regulation of proteasomal protein catabolic process 14/1036 183/18670 0.1397 0.5141 0.4539 RCHY1/USP25/LAMP3/PSMD14/PSMC2/GCLC/RBX1/TRIB2/EDEM1/PSMD10/WAC/UBB/RPL11/UBE2J1 14 GO:0046425 regulation of JAK-STAT cascade 11/1036 137/18670 0.1397 0.5141 0.4539 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 11 GO:0002551 mast cell chemotaxis 2/1036 12/18670 0.1405 0.5141 0.4539 CHGA/CCL11 2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus 2/1036 12/18670 0.1405 0.5141 0.4539 IL12B/PSMA1 2 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 2/1036 12/18670 0.1405 0.5141 0.4539 LIF/SIX2 2 GO:0006568 tryptophan metabolic process 2/1036 12/18670 0.1405 0.5141 0.4539 KMO/KYNU 2 GO:0008228 opsonization 2/1036 12/18670 0.1405 0.5141 0.4539 PTX3/LBP 2 GO:0010623 programmed cell death involved in cell development 2/1036 12/18670 0.1405 0.5141 0.4539 IL1A/IL1B 2 GO:0010826 negative regulation of centrosome duplication 2/1036 12/18670 0.1405 0.5141 0.4539 TRIM37/NPM1 2 GO:0014831 gastro-intestinal system smooth muscle contraction 2/1036 12/18670 0.1405 0.5141 0.4539 SULF1/NMU 2 GO:0016045 detection of bacterium 2/1036 12/18670 0.1405 0.5141 0.4539 TLR6/PGLYRP4 2 GO:0031392 regulation of prostaglandin biosynthetic process 2/1036 12/18670 0.1405 0.5141 0.4539 IL1B/ANXA1 2 GO:0031581 hemidesmosome assembly 2/1036 12/18670 0.1405 0.5141 0.4539 ITGA6/ITGB4 2 GO:0032252 secretory granule localization 2/1036 12/18670 0.1405 0.5141 0.4539 MAP2/RASGRP1 2 GO:0032429 regulation of phospholipase A2 activity 2/1036 12/18670 0.1405 0.5141 0.4539 ANXA1/LRP1 2 GO:0033523 histone H2B ubiquitination 2/1036 12/18670 0.1405 0.5141 0.4539 CTR9/WAC 2 GO:0034086 maintenance of sister chromatid cohesion 2/1036 12/18670 0.1405 0.5141 0.4539 TNKS/ATRX 2 GO:0034088 maintenance of mitotic sister chromatid cohesion 2/1036 12/18670 0.1405 0.5141 0.4539 TNKS/ATRX 2 GO:0043383 negative T cell selection 2/1036 12/18670 0.1405 0.5141 0.4539 CD3E/ATG5 2 GO:0045416 positive regulation of interleukin-8 biosynthetic process 2/1036 12/18670 0.1405 0.5141 0.4539 TNF/ELANE 2 GO:0048302 regulation of isotype switching to IgG isotypes 2/1036 12/18670 0.1405 0.5141 0.4539 MSH2/TBX21 2 GO:0051873 killing by host of symbiont cells 2/1036 12/18670 0.1405 0.5141 0.4539 ELANE/CTSG 2 GO:0051956 negative regulation of amino acid transport 2/1036 12/18670 0.1405 0.5141 0.4539 ABAT/TRH 2 GO:0060453 regulation of gastric acid secretion 2/1036 12/18670 0.1405 0.5141 0.4539 KCNQ1/NMU 2 GO:0072520 seminiferous tubule development 2/1036 12/18670 0.1405 0.5141 0.4539 UBB/ATRX 2 GO:0090148 membrane fission 2/1036 12/18670 0.1405 0.5141 0.4539 SLC25A46/DNM1L 2 GO:0090331 negative regulation of platelet aggregation 2/1036 12/18670 0.1405 0.5141 0.4539 ABAT/CD9 2 GO:0097340 inhibition of cysteine-type endopeptidase activity 2/1036 12/18670 0.1405 0.5141 0.4539 BIRC3/CST7 2 GO:0097341 zymogen inhibition 2/1036 12/18670 0.1405 0.5141 0.4539 BIRC3/CST7 2 GO:0097531 mast cell migration 2/1036 12/18670 0.1405 0.5141 0.4539 CHGA/CCL11 2 GO:0098789 pre-mRNA cleavage required for polyadenylation 2/1036 12/18670 0.1405 0.5141 0.4539 NUDT21/CSTF2T 2 GO:0150065 regulation of deacetylase activity 2/1036 12/18670 0.1405 0.5141 0.4539 FNTA/SPHK2 2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 2/1036 12/18670 0.1405 0.5141 0.4539 CCT7/CCT2 2 GO:1990173 protein localization to nucleoplasm 2/1036 12/18670 0.1405 0.5141 0.4539 CCT7/CCT2 2 GO:2000105 positive regulation of DNA-dependent DNA replication 2/1036 12/18670 0.1405 0.5141 0.4539 ATRX/CDC7 2 GO:0048872 homeostasis of number of cells 18/1036 246/18670 0.141 0.5155 0.4552 SOS1/IL6/LIPA/HSPA9/ZFP36/PDE4B/TGFBR3/ANXA1/DYRK3/GPR183/FH/SPI1/PMAIP1/SOD1/RHAG/BCR/NCAPG2/ZBTB7A 18 GO:0043407 negative regulation of MAP kinase activity 7/1036 78/18670 0.1413 0.5162 0.4558 AIDA/DUSP2/IL1B/STK38/PTPN22/DUSP21/PAQR3 7 GO:0007179 transforming growth factor beta receptor signaling pathway 15/1036 199/18670 0.1416 0.5166 0.4562 PARP1/TGFBR2/FLCN/USP9Y/HTRA1/ACVR1/FNTA/TGFBR3/BMPR1B/UBA52/STK11/CITED2/AMHR2/UBB/ZBTB7A 15 GO:0016052 carbohydrate catabolic process 15/1036 199/18670 0.1416 0.5166 0.4562 PGK1/NUP107/IFNG/DERA/NUP37/ENOSF1/NUP205/PHKG1/NUP85/HDAC4/PFKP/NCOR1/NUP160/NUP214/ZBTB7A 15 GO:0034614 cellular response to reactive oxygen species 13/1036 168/18670 0.1417 0.5166 0.4562 PCNA/IL6/SOD3/MTR/TNF/TRPM2/ANXA1/MAPK3/PDE8A/AKR1C3/SETX/SOD1/CBX8 13 GO:0014009 glial cell proliferation 5/1036 50/18670 0.1426 0.5188 0.4581 IL6/IL1B/PRKCH/PPP1CC/TNF 5 GO:0031113 regulation of microtubule polymerization 5/1036 50/18670 0.1426 0.5188 0.4581 MAP2/RANGRF/CLASP1/DYRK1A/TERF1 5 GO:0043489 RNA stabilization 5/1036 50/18670 0.1426 0.5188 0.4581 HNRNPA0/ZFP36/PAIP1/ELAVL1/PABPC1 5 GO:0002228 natural killer cell mediated immunity 6/1036 64/18670 0.1432 0.5196 0.4588 CD96/SH2D1A/KLRD1/IL12B/GZMB/RASGRP1 6 GO:0006360 transcription by RNA polymerase I 6/1036 64/18670 0.1432 0.5196 0.4588 NOL11/POLR1B/GTF2H3/MAPK3/TBP/TAF1C 6 GO:0035794 positive regulation of mitochondrial membrane permeability 6/1036 64/18670 0.1432 0.5196 0.4588 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0045669 positive regulation of osteoblast differentiation 6/1036 64/18670 0.1432 0.5196 0.4588 IL6/GNAS/ACVR1/BMPR1B/PDLIM7/FBXO5 6 GO:0042133 neurotransmitter metabolic process 12/1036 153/18670 0.1434 0.52 0.4592 ABAT/IFNG/IL1B/SLC25A32/PTX3/RORA/TNF/TRH/TLR6/GAD2/KHSRP/SLC1A3 12 GO:0003073 regulation of systemic arterial blood pressure 8/1036 93/18670 0.1442 0.5222 0.4612 HSD11B2/NTSR1/EMP2/PLCB3/AVPR1B/CTSG/CYP4A11/CYP4F12 8 GO:0006476 protein deacetylation 8/1036 93/18670 0.1442 0.5222 0.4612 IFNG/SFPQ/BEX4/FNTA/SPHK2/HDAC4/DYRK1A/ZNHIT1 8 GO:0008584 male gonad development 11/1036 138/18670 0.1447 0.5227 0.4616 ARID5B/MSH2/TLR3/RARA/CITED2/AKR1C3/AMHR2/SRY/UBB/ATRX/ADAM15 11 GO:0010506 regulation of autophagy 23/1036 327/18670 0.1448 0.5227 0.4616 OPTN/IFNG/FLCN/LAMP3/CAPN1/NPC1/SESN1/SCFD1/HERC1/PTPN22/DAPK2/CSNK2A2/DNM1L/XBP1/EXOC7/PIK3CA/MAPK3/FYCO1/STK11/WAC/HAX1/KAT8/FEZ1 23 GO:0099565 chemical synaptic transmission, postsynaptic 9/1036 108/18670 0.1454 0.5227 0.4616 ABAT/P2RX5/EIF4A3/P2RX1/NTSR1/CHRNA2/GLRA1/P2RX6/GRIN2D 9 GO:2000278 regulation of DNA biosynthetic process 9/1036 108/18670 0.1454 0.5227 0.4616 MYC/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/TERF1 9 GO:0002861 regulation of inflammatory response to antigenic stimulus 3/1036 24/18670 0.1455 0.5227 0.4616 IL12B/PSMA1/TNF 3 GO:0033081 regulation of T cell differentiation in thymus 3/1036 24/18670 0.1455 0.5227 0.4616 SOS1/RASGRP1/SOD1 3 GO:0044346 fibroblast apoptotic process 3/1036 24/18670 0.1455 0.5227 0.4616 MYC/PIK3CA/XRCC2 3 GO:0046475 glycerophospholipid catabolic process 3/1036 24/18670 0.1455 0.5227 0.4616 PNPLA6/PRDX6/GDPD3 3 GO:0050687 negative regulation of defense response to virus 3/1036 24/18670 0.1455 0.5227 0.4616 C1QBP/HTRA1/GPATCH3 3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 3/1036 24/18670 0.1455 0.5227 0.4616 TRAT1/PRKCH/LCK 3 GO:0060148 positive regulation of posttranscriptional gene silencing 3/1036 24/18670 0.1455 0.5227 0.4616 ZFP36/PUM1/FXR1 3 GO:0062009 secondary palate development 3/1036 24/18670 0.1455 0.5227 0.4616 TGFBR2/TGFBR3/FZD2 3 GO:0050769 positive regulation of neurogenesis 32/1036 474/18670 0.1458 0.5234 0.4621 IL6/IFNG/IL1B/PRKCH/NCK1/ITGA6/CPNE6/FYN/PPP1CC/TNF/CAPRIN2/CXCR4/PLXNB2/LRP1/DNM1L/NAP1L1/SMARCD3/SPINT1/RARA/LIF/TIMP2/TMEM106B/STK11/DBN1/CAPRIN1/DSCAM/MMD/SETX/NTN1/ADNP/XRCC2/FEZ1 32 GO:0015698 inorganic anion transport 13/1036 169/18670 0.1463 0.5246 0.4632 ABCB1/CLIC2/VDAC3/SLC12A5/CLNS1A/BEST1/LRRC8B/GLRA1/GABRB2/CA7/GABRP/SLC20A1/SLC1A3 13 GO:0002714 positive regulation of B cell mediated immunity 4/1036 37/18670 0.1473 0.5254 0.4639 TNFSF13/TNF/MSH2/TBX21 4 GO:0002891 positive regulation of immunoglobulin mediated immune response 4/1036 37/18670 0.1473 0.5254 0.4639 TNFSF13/TNF/MSH2/TBX21 4 GO:0006270 DNA replication initiation 4/1036 37/18670 0.1473 0.5254 0.4639 ORC3/ORC2/ORC4/MCM6 4 GO:0031111 negative regulation of microtubule polymerization or depolymerization 4/1036 37/18670 0.1473 0.5254 0.4639 CKAP2/MAP2/CLASP1/DYRK1A 4 GO:0071276 cellular response to cadmium ion 4/1036 37/18670 0.1473 0.5254 0.4639 MAPK3/AKR1C3/DAXX/SOD1 4 GO:1903432 regulation of TORC1 signaling 4/1036 37/18670 0.1473 0.5254 0.4639 FLCN/SESN1/STK11/DYRK3 4 GO:2000142 regulation of DNA-templated transcription, initiation 4/1036 37/18670 0.1473 0.5254 0.4639 PSMC2/BCLAF1/SETX/PSMC5 4 GO:2000273 positive regulation of signaling receptor activity 4/1036 37/18670 0.1473 0.5254 0.4639 IFNG/RWDD1/NCOA3/NCAPG2 4 GO:0000302 response to reactive oxygen species 17/1036 232/18670 0.1479 0.5273 0.4656 PCNA/IL6/CAT/SOD3/SESN1/MTR/HP/FYN/TNF/TRPM2/ANXA1/MAPK3/PDE8A/AKR1C3/SETX/SOD1/CBX8 17 GO:0010770 positive regulation of cell morphogenesis involved in differentiation 12/1036 154/18670 0.1482 0.5281 0.4663 C1QBP/CAPRIN2/PLXNB2/LRP1/DNM1L/ARHGEF7/STK11/DBN1/CAPRIN1/DSCAM/NTN1/ADNP 12 GO:1902275 regulation of chromatin organization 14/1036 185/18670 0.1484 0.5281 0.4663 AUTS2/BRD7/CTR9/IL1B/FLCN/SART3/HIRA/MAPK3/LIF/SPHK2/SPI1/ZNHIT1/ATRX/ATG5 14 GO:0046879 hormone secretion 22/1036 312/18670 0.1484 0.5281 0.4663 CD38/ABAT/CCL5/IL6/IFNG/IL1B/OXCT1/PASK/UBE2Q1/GNAS/SLC25A5/DYNLL1/CHGA/CRY1/TNF/ANXA1/LRP1/TRH/LIF/AIMP1/GHRHR/NMU 22 GO:0033135 regulation of peptidyl-serine phosphorylation 11/1036 139/18670 0.1498 0.5324 0.4701 IL6/IFNG/NCK1/PLCL1/TNF/CAPRIN2/PIK3CA/GPD1L/LIF/HAX1/PAQR3 11 GO:0046546 development of primary male sexual characteristics 11/1036 139/18670 0.1498 0.5324 0.4701 ARID5B/MSH2/TLR3/RARA/CITED2/AKR1C3/AMHR2/SRY/UBB/ATRX/ADAM15 11 GO:0044728 DNA methylation or demethylation 8/1036 94/18670 0.1505 0.5341 0.4717 PARP1/MYC/GNAS/PIK3CA/APOBEC3G/SPI1/ATRX/METTL4 8 GO:1901216 positive regulation of neuron death 8/1036 94/18670 0.1505 0.5341 0.4717 PARP1/IFNG/KMO/FYN/TNF/HDAC4/TLR6/DAXX 8 GO:0050854 regulation of antigen receptor-mediated signaling pathway 6/1036 65/18670 0.1509 0.5345 0.472 TRAT1/PRKCH/MALT1/PTPN22/LCK/LILRB4 6 GO:0051187 cofactor catabolic process 6/1036 65/18670 0.1509 0.5345 0.472 CAT/HP/NNT/AHCY/PRDX6/ACAT1 6 GO:0048284 organelle fusion 10/1036 124/18670 0.1509 0.5345 0.472 MFN1/ANXA1/STX10/STX8/DNM1L/TBC1D4/CHCHD3/VAT1/MFF/GOSR1 10 GO:0008406 gonad development 16/1036 217/18670 0.1511 0.5347 0.4721 ARID5B/NUP107/PTX3/BMPR1B/MSH2/TLR3/RARA/TSPY1/CITED2/AKR1C3/AMHR2/SRY/UBB/SOD1/ATRX/ADAM15 16 GO:0000731 DNA synthesis involved in DNA repair 5/1036 51/18670 0.1514 0.5347 0.4722 PCNA/RCHY1/UBA52/UBB/RPA1 5 GO:0019369 arachidonic acid metabolic process 5/1036 51/18670 0.1514 0.5347 0.4722 MAPK3/CYP2C9/AKR1C3/CYP4A11/CYP4F12 5 GO:0045599 negative regulation of fat cell differentiation 5/1036 51/18670 0.1514 0.5347 0.4722 IL6/RORA/INSIG1/TNF/TRIB2 5 GO:0019318 hexose metabolic process 18/1036 249/18670 0.1523 0.5374 0.4746 DYRK2/MDH1/CREM/PGK1/DUSP12/PASK/RORA/CRY1/COX11/TNF/ATF3/CLK2/PIK3CA/AKR1B1/HECTD4/PFKP/PMAIP1/PDHB 18 GO:0060968 regulation of gene silencing 12/1036 155/18670 0.1531 0.539 0.476 NUP107/NUP37/ZFP36/HIRA/NUP205/ELAVL1/PUM1/NUP85/NCOR1/NUP160/NUP214/FXR1 12 GO:2001236 regulation of extrinsic apoptotic signaling pathway 12/1036 155/18670 0.1531 0.539 0.476 IL1A/IL1B/ITGA6/GCLC/ACVR1/FYN/TNF/SIAH2/ATF3/BMPR1B/PMAIP1/ZMYND11 12 GO:0033865 nucleoside bisphosphate metabolic process 11/1036 140/18670 0.155 0.539 0.476 SUCLA2/DLD/PDHX/PPCS/SUCLG2/TPST1/KYNU/SUCLG1/ACSL3/PDHB/ACAT1 11 GO:0033875 ribonucleoside bisphosphate metabolic process 11/1036 140/18670 0.155 0.539 0.476 SUCLA2/DLD/PDHX/PPCS/SUCLG2/TPST1/KYNU/SUCLG1/ACSL3/PDHB/ACAT1 11 GO:0034032 purine nucleoside bisphosphate metabolic process 11/1036 140/18670 0.155 0.539 0.476 SUCLA2/DLD/PDHX/PPCS/SUCLG2/TPST1/KYNU/SUCLG1/ACSL3/PDHB/ACAT1 11 GO:0034620 cellular response to unfolded protein 11/1036 140/18670 0.155 0.539 0.476 OPTN/NCK1/HSPA9/DERL1/ATF3/XBP1/EDEM1/HSPA14/DAXX/PIK3R1/GFPT1 11 GO:0046330 positive regulation of JNK cascade 11/1036 140/18670 0.155 0.539 0.476 SLAMF1/IL1B/TNF/IL36A/RASGRP1/TLR3/MAP4K5/MAP4K2/TLR6/DAXX/EDA2R 11 GO:0003205 cardiac chamber development 13/1036 171/18670 0.1555 0.539 0.476 SOS1/TGFBR2/ACVR1/TNNI1/TGFBR3/SMARCD3/PARVA/RARA/RBM15/CITED2/HEG1/AP2B1/FZD2 13 GO:0048588 developmental cell growth 17/1036 234/18670 0.1558 0.539 0.476 AUTS2/TGFBR2/ITGA4/ARHGAP4/CPNE6/CXCR4/MEX3C/MAP2/LRP1/SEMA4G/CYFIP2/SEMA3G/STK11/DBN1/DSCAM/NTN1/ADNP 17 GO:0045471 response to ethanol 10/1036 125/18670 0.1565 0.539 0.476 ABAT/OXCT1/CAT/PSMD14/FYN/RARA/GLRA1/TRH/SPI1/SOD1 10 GO:0061387 regulation of extent of cell growth 9/1036 110/18670 0.1572 0.539 0.476 ARHGAP4/MAP2/LRP1/SEMA4G/SEMA3G/DBN1/DSCAM/NTN1/ADNP 9 GO:0098739 import across plasma membrane 9/1036 110/18670 0.1572 0.539 0.476 IFNG/FYN/NTSR1/FAM155B/SLC12A5/TRPM2/ATP1B1/SLC39A6/SLC1A3 9 GO:0016572 histone phosphorylation 4/1036 38/18670 0.1579 0.539 0.476 IL1B/AURKC/MAPK3/VRK1 4 GO:0048246 macrophage chemotaxis 4/1036 38/18670 0.1579 0.539 0.476 CCL5/NUP85/MAPK3/SLAMF8 4 GO:0051590 positive regulation of neurotransmitter transport 4/1036 38/18670 0.1579 0.539 0.476 KMO/NTSR1/DNM1L/TRH 4 GO:0071214 cellular response to abiotic stimulus 23/1036 331/18670 0.158 0.539 0.476 PCNA/PARP1/MYC/NFKB1/IL1B/METAP1/GCLC/PIEZO2/CRY1/FNTA/ATR/TLR3/METAP2/NPM1/MAPK3/HDAC4/AKR1B1/STK11/PTGER4/MCOLN1/TRPM1/SLC38A2/PIK3R1 23 GO:0104004 cellular response to environmental stimulus 23/1036 331/18670 0.158 0.539 0.476 PCNA/PARP1/MYC/NFKB1/IL1B/METAP1/GCLC/PIEZO2/CRY1/FNTA/ATR/TLR3/METAP2/NPM1/MAPK3/HDAC4/AKR1B1/STK11/PTGER4/MCOLN1/TRPM1/SLC38A2/PIK3R1 23 GO:0051053 negative regulation of DNA metabolic process 12/1036 156/18670 0.1581 0.539 0.476 PARP1/S100A11/FLCN/GZMA/MSH2/ATR/GMNN/TNKS/FBXO5/TERF1/DONSON/POLQ 12 GO:0015800 acidic amino acid transport 6/1036 66/18670 0.1587 0.539 0.476 ABAT/KMO/NTSR1/TRH/SLC38A2/SLC1A3 6 GO:0045428 regulation of nitric oxide biosynthetic process 6/1036 66/18670 0.1587 0.539 0.476 IFNG/IL1B/PTX3/TNF/TLR6/KHSRP 6 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 6/1036 66/18670 0.1587 0.539 0.476 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:1905710 positive regulation of membrane permeability 6/1036 66/18670 0.1587 0.539 0.476 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0001945 lymph vessel development 3/1036 25/18670 0.159 0.539 0.476 LGALS8/TMEM204/HEG1 3 GO:0002719 negative regulation of cytokine production involved in immune response 3/1036 25/18670 0.159 0.539 0.476 CD96/TNF/TBX21 3 GO:0009648 photoperiodism 3/1036 25/18670 0.159 0.539 0.476 CRY1/PPP1CC/NMU 3 GO:0014829 vascular smooth muscle contraction 3/1036 25/18670 0.159 0.539 0.476 CD38/P2RX1/PIK3C2A 3 GO:0019430 removal of superoxide radicals 3/1036 25/18670 0.159 0.539 0.476 SOD3/TNF/SOD1 3 GO:0031639 plasminogen activation 3/1036 25/18670 0.159 0.539 0.476 PGK1/PLGRKT/F12 3 GO:0035459 cargo loading into vesicle 3/1036 25/18670 0.159 0.539 0.476 INSIG1/SEC24A/TMED2 3 GO:0045724 positive regulation of cilium assembly 3/1036 25/18670 0.159 0.539 0.476 ATMIN/DYNLL1/ZMYND10 3 GO:0045830 positive regulation of isotype switching 3/1036 25/18670 0.159 0.539 0.476 TNFSF13/MSH2/TBX21 3 GO:0051654 establishment of mitochondrion localization 3/1036 25/18670 0.159 0.539 0.476 UXT/UBB/FEZ1 3 GO:0070199 establishment of protein localization to chromosome 3/1036 25/18670 0.159 0.539 0.476 CCT7/CCT2/TERF1 3 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 3/1036 25/18670 0.159 0.539 0.476 NCK1/XBP1/PIK3R1 3 GO:0043087 regulation of GTPase activity 32/1036 479/18670 0.1596 0.539 0.476 RHOH/SOS1/CCL5/FLCN/ARHGAP17/ITGA6/RASA1/RAPGEF6/ARHGAP4/RGS1/ADAP2/TBC1D2/RABGAP1L/PLXNB2/RASGRP1/DNM1L/ARHGEF7/RIC8B/MYO9B/TBC1D4/RALGAPA1/ASAP2/CCL11/EIF5/SOD1/CCL25/ZC3H15/TBC1D9/SH3BP1/CCL23/BCR/TMED2 32 GO:0046777 protein autophosphorylation 17/1036 235/18670 0.1598 0.539 0.476 PPP2R5C/PASK/FYN/TXK/DAPK2/ITK/PRKX/CLK2/ATR/LCK/MAPK3/STK11/VRK1/RIOK2/DYRK1A/TRIM24/BCR 17 GO:0060560 developmental growth involved in morphogenesis 17/1036 235/18670 0.1598 0.539 0.476 AUTS2/TGFBR2/ITGA4/ARHGAP4/CPNE6/CXCR4/MAP2/LRP1/SEMA4G/CYFIP2/SEMA3G/STK11/CCL11/DBN1/DSCAM/NTN1/ADNP 17 GO:0000212 meiotic spindle organization 2/1036 13/18670 0.1603 0.539 0.476 FBXO5/ATRX 2 GO:0001765 membrane raft assembly 2/1036 13/18670 0.1603 0.539 0.476 EMP2/RFTN1 2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process 2/1036 13/18670 0.1603 0.539 0.476 GLRA1/TLX3 2 GO:0002679 respiratory burst involved in defense response 2/1036 13/18670 0.1603 0.539 0.476 SLAMF8/LBP 2 GO:0002829 negative regulation of type 2 immune response 2/1036 13/18670 0.1603 0.539 0.476 ANXA1/TBX21 2 GO:0006384 transcription initiation from RNA polymerase III promoter 2/1036 13/18670 0.1603 0.539 0.476 GTF3C3/TBP 2 GO:0006553 lysine metabolic process 2/1036 13/18670 0.1603 0.539 0.476 DLD/AASDHPPT 2 GO:0018206 peptidyl-methionine modification 2/1036 13/18670 0.1603 0.539 0.476 METAP1/METAP2 2 GO:0019627 urea metabolic process 2/1036 13/18670 0.1603 0.539 0.476 OTC/CYP2C9 2 GO:0031115 negative regulation of microtubule polymerization 2/1036 13/18670 0.1603 0.539 0.476 MAP2/DYRK1A 2 GO:0032488 Cdc42 protein signal transduction 2/1036 13/18670 0.1603 0.539 0.476 WAS/NTN1 2 GO:0033127 regulation of histone phosphorylation 2/1036 13/18670 0.1603 0.539 0.476 IL1B/MAPK3 2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 2/1036 13/18670 0.1603 0.539 0.476 LBH/PHB2 2 GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 2/1036 13/18670 0.1603 0.539 0.476 GPR171/P2RY10 2 GO:0043248 proteasome assembly 2/1036 13/18670 0.1603 0.539 0.476 PSMG2/PSMD10 2 GO:0045059 positive thymic T cell selection 2/1036 13/18670 0.1603 0.539 0.476 STK11/CD3E 2 GO:0045078 positive regulation of interferon-gamma biosynthetic process 2/1036 13/18670 0.1603 0.539 0.476 IL12B/TLR3 2 GO:0045779 negative regulation of bone resorption 2/1036 13/18670 0.1603 0.539 0.476 CD38/IL6 2 GO:0048291 isotype switching to IgG isotypes 2/1036 13/18670 0.1603 0.539 0.476 MSH2/TBX21 2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 2/1036 13/18670 0.1603 0.539 0.476 FYN/CXCR4 2 GO:0061042 vascular wound healing 2/1036 13/18670 0.1603 0.539 0.476 CXCR4/XBP1 2 GO:0070071 proton-transporting two-sector ATPase complex assembly 2/1036 13/18670 0.1603 0.539 0.476 TMEM70/OXA1L 2 GO:0070986 left/right axis specification 2/1036 13/18670 0.1603 0.539 0.476 HSPB11/CITED2 2 GO:0071872 cellular response to epinephrine stimulus 2/1036 13/18670 0.1603 0.539 0.476 PDE4B/KCNQ1 2 GO:0090713 immunological memory process 2/1036 13/18670 0.1603 0.539 0.476 IL12B/IL23A 2 GO:0098712 L-glutamate import across plasma membrane 2/1036 13/18670 0.1603 0.539 0.476 NTSR1/SLC1A3 2 GO:0098787 mRNA cleavage involved in mRNA processing 2/1036 13/18670 0.1603 0.539 0.476 NUDT21/CSTF2T 2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 2/1036 13/18670 0.1603 0.539 0.476 XBP1/PIK3R1 2 GO:1900225 regulation of NLRP3 inflammasome complex assembly 2/1036 13/18670 0.1603 0.539 0.476 TLR6/ATAT1 2 GO:1901550 regulation of endothelial cell development 2/1036 13/18670 0.1603 0.539 0.476 IL1B/TNF 2 GO:1902855 regulation of non-motile cilium assembly 2/1036 13/18670 0.1603 0.539 0.476 ATMIN/DYNLL1 2 GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 2/1036 13/18670 0.1603 0.539 0.476 HDAC4/LILRB4 2 GO:1902902 negative regulation of autophagosome assembly 2/1036 13/18670 0.1603 0.539 0.476 SCFD1/FEZ1 2 GO:1903140 regulation of establishment of endothelial barrier 2/1036 13/18670 0.1603 0.539 0.476 IL1B/TNF 2 GO:1904293 negative regulation of ERAD pathway 2/1036 13/18670 0.1603 0.539 0.476 USP25/UBE2J1 2 GO:0070585 protein localization to mitochondrion 11/1036 141/18670 0.1603 0.539 0.476 MOAP1/GZMB/CSNK2A2/YWHAQ/DNM1L/OXA1L/AGK/TOMM20/PMAIP1/HAX1/MFF 11 GO:0032330 regulation of chondrocyte differentiation 5/1036 52/18670 0.1604 0.539 0.476 BMPR1B/ZBTB16/FGF18/SIX2/MAF 5 GO:0045839 negative regulation of mitotic nuclear division 5/1036 52/18670 0.1604 0.539 0.476 PSMG2/NDC80/TNKS/FBXO5/ATRX 5 GO:1902373 negative regulation of mRNA catabolic process 5/1036 52/18670 0.1604 0.539 0.476 HNRNPA0/ZFP36/PAIP1/ELAVL1/PABPC1 5 GO:0042176 regulation of protein catabolic process 26/1036 381/18670 0.1616 0.5429 0.4794 IFNG/RCHY1/IL1B/DACT1/USP25/CTSC/LAMP3/ODC1/PSMD14/PSMC2/GCLC/FYN/TNF/RBX1/RPS7/TRIB2/CSNK2A2/LRP1/EDEM1/TIMP2/TIMP4/PSMD10/WAC/UBB/RPL11/UBE2J1 26 GO:0043902 positive regulation of multi-organism process 14/1036 188/18670 0.1619 0.5434 0.4798 OPTN/CCL5/IFNG/C1QBP/PRF1/DDX60/ANKRD17/PUM1/GLRA1/MAPK3/PABPC1/HDAC4/VPS37B/PGLYRP4 14 GO:0034109 homotypic cell-cell adhesion 7/1036 81/18670 0.1622 0.5443 0.4806 ABAT/CCL5/METAP1/PRKCQ/GNAS/CD99/CD9 7 GO:0006869 lipid transport 25/1036 365/18670 0.1628 0.5457 0.4818 NFKB1/ABCD3/ABCB1/ESYT1/IL1B/APOL3/CETP/LDLRAP1/NPC1/NTSR1/CRY1/ANXA1/ATP8A1/LRP1/STARD7/SLC10A2/SCP2/PON1/ABCC4/VPS51/ACSL3/PLA2G3/NCOR1/CYP4A11/LBP 25 GO:0006835 dicarboxylic acid transport 8/1036 96/18670 0.1635 0.5477 0.4836 FOLR3/ABAT/SLC25A32/KMO/NTSR1/TRH/SLC38A2/SLC1A3 8 GO:0010675 regulation of cellular carbohydrate metabolic process 11/1036 142/18670 0.1656 0.5541 0.4893 DYRK2/DUSP12/PASK/RORA/CD244/NTSR1/CRY1/COX11/CLK2/HDAC4/PMAIP1 11 GO:0038127 ERBB signaling pathway 11/1036 142/18670 0.1656 0.5541 0.4893 SOS1/CBLB/ERBB3/ARHGEF7/CPNE3/PIK3CA/EPS15L1/PIK3C2A/DOK1/RNF115/PIK3R1 11 GO:0070371 ERK1 and ERK2 cascade 22/1036 317/18670 0.1657 0.5541 0.4893 SLAMF1/MYC/CCL5/RANBP9/IL1B/FLCN/RRAS/TNF/PTPN22/ATF3/PHB2/LRP1/RASGRP1/MAPK3/LIF/PDE8A/CCL11/PTGER4/GPR183/CCL25/FGF18/CCL23 22 GO:0043967 histone H4 acetylation 6/1036 67/18670 0.1668 0.5573 0.4921 AUTS2/HAT1/SPI1/KANSL2/KAT8/ATG5 6 GO:0006605 protein targeting 29/1036 432/18670 0.167 0.5577 0.4925 ZDHHC4/CAT/FYN/RPL6/SRP72/RPS7/RPS5/RPL35/CSNK2A2/YWHAQ/RPS4Y1/TRAM1/RPL35A/UBA52/SCP2/RPL19/RPL29/VPS37B/AGK/RPL15/TOMM20/UBB/RPS21/RPL11/HAX1/MFF/RPL22/RPL36/SPCS1 29 GO:0007210 serotonin receptor signaling pathway 4/1036 39/18670 0.1687 0.5614 0.4957 CHRM5/HRH2/OR10H1/CHRM2 4 GO:0043001 Golgi to plasma membrane protein transport 4/1036 39/18670 0.1687 0.5614 0.4957 OPTN/ANXA13/C16orf70/ACSL3 4 GO:0050775 positive regulation of dendrite morphogenesis 4/1036 39/18670 0.1687 0.5614 0.4957 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:0072595 maintenance of protein localization in organelle 4/1036 39/18670 0.1687 0.5614 0.4957 SKP1/INSIG1/SUPT7L/SYNE1 4 GO:1901998 toxin transport 4/1036 39/18670 0.1687 0.5614 0.4957 CCT7/SCFD1/CCT2/HRH2 4 GO:1905521 regulation of macrophage migration 4/1036 39/18670 0.1687 0.5614 0.4957 CCL5/MAPK3/CD9/SLAMF8 4 GO:0006354 DNA-templated transcription, elongation 9/1036 112/18670 0.1694 0.5618 0.4961 CTR9/TCEA1/POLR1B/GTF2H3/MLLT3/HMGN1/TBP/ZMYND11/TAF1C 9 GO:0034644 cellular response to UV 7/1036 82/18670 0.1695 0.5618 0.4961 PCNA/PARP1/MYC/ATR/NPM1/STK11/PIK3R1 7 GO:0046209 nitric oxide metabolic process 7/1036 82/18670 0.1695 0.5618 0.4961 IFNG/IL1B/PTX3/RORA/TNF/TLR6/KHSRP 7 GO:0097581 lamellipodium organization 7/1036 82/18670 0.1695 0.5618 0.4961 AUTS2/NCK1/WAS/ARHGEF7/NUP85/HDAC4/ABLIM1 7 GO:0035036 sperm-egg recognition 5/1036 53/18670 0.1696 0.5618 0.4961 FOLR3/CCT7/CCT2/CD9/CATSPERG 5 GO:0042073 intraciliary transport 5/1036 53/18670 0.1696 0.5618 0.4961 IFT22/DYNLL1/HSPB11/KIFAP3/PCM1 5 GO:1905517 macrophage migration 5/1036 53/18670 0.1696 0.5618 0.4961 CCL5/NUP85/MAPK3/CD9/SLAMF8 5 GO:0010876 lipid localization 27/1036 400/18670 0.1699 0.5627 0.4968 NFKB1/ABCD3/IL6/ABCB1/ESYT1/IL1B/APOL3/CETP/LDLRAP1/NPC1/NTSR1/CRY1/TNF/ANXA1/ATP8A1/LRP1/STARD7/SLC10A2/SCP2/PON1/ABCC4/VPS51/ACSL3/PLA2G3/NCOR1/CYP4A11/LBP 27 GO:0090630 activation of GTPase activity 8/1036 97/18670 0.1701 0.5629 0.4971 TBC1D2/RABGAP1L/RASGRP1/TBC1D4/RALGAPA1/EIF5/TBC1D9/BCR 8 GO:0006606 protein import into nucleus 11/1036 143/18670 0.1711 0.5633 0.4974 NUP107/IFNG/CBLB/RANBP6/PHB2/NUP85/CSE1L/PIK3R1/SIX2/NUP214/IPO7 11 GO:0030879 mammary gland development 11/1036 143/18670 0.1711 0.5633 0.4974 LBH/TGFBR2/CAPN1/PHB2/XBP1/USF2/CCL11/CSN2/GHRHR/NTN1/APRT 11 GO:0060070 canonical Wnt signaling pathway 23/1036 335/18670 0.1718 0.5633 0.4974 NFKB1/DACT1/PSMA2/DAAM2/PSMA5/PSMD14/PSMA1/PSMC2/SIAH2/RBX1/RECK/CAPRIN2/PSME4/PSMD12/MLLT3/TNKS/PSMB1/BICC1/STK11/PSMD10/PSMC5/FZD2/PSMA3 23 GO:0070663 regulation of leukocyte proliferation 16/1036 222/18670 0.1722 0.5633 0.4974 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/NCK1/PRKCQ/IL12B/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/CLC 16 GO:0046578 regulation of Ras protein signal transduction 17/1036 238/18670 0.1723 0.5633 0.4974 AUTS2/ARHGEF3/SOS1/FLCN/GPR18/RASA1/RASGRP1/ARHGEF7/ARHGEF17/MYO9B/TIMP2/HEG1/LPAR6/ARHGEF28/IQSEC3/P2RY10/BCR 17 GO:0000244 spliceosomal tri-snRNP complex assembly 3/1036 26/18670 0.1728 0.5633 0.4974 SRSF10/SART3/PRPF8 3 GO:0001916 positive regulation of T cell mediated cytotoxicity 3/1036 26/18670 0.1728 0.5633 0.4974 IL12B/CD1A/IL23A 3 GO:0010460 positive regulation of heart rate 3/1036 26/18670 0.1728 0.5633 0.4974 ATP2A2/KCNQ1/NMU 3 GO:0010758 regulation of macrophage chemotaxis 3/1036 26/18670 0.1728 0.5633 0.4974 CCL5/MAPK3/SLAMF8 3 GO:0022400 regulation of rhodopsin mediated signaling pathway 3/1036 26/18670 0.1728 0.5633 0.4974 METAP1/FNTA/METAP2 3 GO:0030206 chondroitin sulfate biosynthetic process 3/1036 26/18670 0.1728 0.5633 0.4974 SLC35D1/CHST12/CHPF2 3 GO:0031645 negative regulation of neurological system process 3/1036 26/18670 0.1728 0.5633 0.4974 CTSC/EIF4A3/GLRA1 3 GO:0032366 intracellular sterol transport 3/1036 26/18670 0.1728 0.5633 0.4974 LDLRAP1/NPC1/SCP2 3 GO:0032367 intracellular cholesterol transport 3/1036 26/18670 0.1728 0.5633 0.4974 LDLRAP1/NPC1/SCP2 3 GO:0032800 receptor biosynthetic process 3/1036 26/18670 0.1728 0.5633 0.4974 IFNG/TNF/SEC24A 3 GO:0034453 microtubule anchoring 3/1036 26/18670 0.1728 0.5633 0.4974 CEP57/PCM1/CLASP1 3 GO:0035640 exploration behavior 3/1036 26/18670 0.1728 0.5633 0.4974 ABAT/EIF4A3/JPH3 3 GO:0042745 circadian sleep/wake cycle 3/1036 26/18670 0.1728 0.5633 0.4974 AHCY/GHRHR/NMU 3 GO:0097066 response to thyroid hormone 3/1036 26/18670 0.1728 0.5633 0.4974 GCLC/AKR1B1/TOMM20 3 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/1036 26/18670 0.1728 0.5633 0.4974 GZMB/YWHAQ/PMAIP1 3 GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/1036 26/18670 0.1728 0.5633 0.4974 GZMB/YWHAQ/PMAIP1 3 GO:1903203 regulation of oxidative stress-induced neuron death 3/1036 26/18670 0.1728 0.5633 0.4974 PARP1/LANCL1/TLR6 3 GO:1903579 negative regulation of ATP metabolic process 3/1036 26/18670 0.1728 0.5633 0.4974 PARP1/FLCN/HDAC4 3 GO:1904353 regulation of telomere capping 3/1036 26/18670 0.1728 0.5633 0.4974 PRKCQ/MAPK3/TNKS 3 GO:0042391 regulation of membrane potential 29/1036 434/18670 0.1732 0.5642 0.4982 PARP1/ABAT/P2RX5/DLD/ATP2A2/EIF4A3/P2RX1/GCLC/PIEZO2/NTSR1/SCN10A/NNT/CHRNA2/GLRA1/GPD1L/ATP1B1/KCNH1/CACNB4/GABRB2/RANGRF/P2RX6/EHD3/GABRP/UBB/PMAIP1/SOD1/KCNQ1/NDUFS1/GRIN2D 29 GO:0033866 nucleoside bisphosphate biosynthetic process 6/1036 68/18670 0.1749 0.5676 0.5012 DLD/PDHX/PPCS/ACSL3/PDHB/ACAT1 6 GO:0034030 ribonucleoside bisphosphate biosynthetic process 6/1036 68/18670 0.1749 0.5676 0.5012 DLD/PDHX/PPCS/ACSL3/PDHB/ACAT1 6 GO:0034033 purine nucleoside bisphosphate biosynthetic process 6/1036 68/18670 0.1749 0.5676 0.5012 DLD/PDHX/PPCS/ACSL3/PDHB/ACAT1 6 GO:0071230 cellular response to amino acid stimulus 6/1036 68/18670 0.1749 0.5676 0.5012 SESN1/GCLC/FYN/TNF/XBP1/GLRA1 6 GO:0032200 telomere organization 13/1036 175/18670 0.175 0.5676 0.5012 PCNA/PARP1/MYC/CCT7/PRKCQ/CCT2/ATR/MAPK3/TNKS/HNRNPA2B1/ATRX/RPA1/TERF1 13 GO:0006333 chromatin assembly or disassembly 14/1036 191/18670 0.176 0.5676 0.5012 ITGB3BP/HAT1/RBBP4/SART3/HIRA/GATAD1/NAP1L1/SMARCD3/NPM1/TSPY1/RBBP7/DAXX/ATRX/SMARCA5 14 GO:0051402 neuron apoptotic process 17/1036 239/18670 0.1765 0.5676 0.5012 PARP1/NAE1/RASA1/BTG2/GCLC/FYN/ERBB3/TNF/LANCL1/MSH2/LRP1/PIK3CA/HDAC4/GABRB2/SOD1/ADNP/XRCC2 17 GO:0045913 positive regulation of carbohydrate metabolic process 7/1036 83/18670 0.1769 0.5676 0.5012 DYRK2/NFKB1/IFNG/DUSP12/CD244/NTSR1/PMAIP1 7 GO:0098659 inorganic cation import across plasma membrane 7/1036 83/18670 0.1769 0.5676 0.5012 IFNG/FYN/FAM155B/SLC12A5/TRPM2/ATP1B1/SLC39A6 7 GO:0099587 inorganic ion import across plasma membrane 7/1036 83/18670 0.1769 0.5676 0.5012 IFNG/FYN/FAM155B/SLC12A5/TRPM2/ATP1B1/SLC39A6 7 GO:1904645 response to amyloid-beta 5/1036 54/18670 0.179 0.5676 0.5012 PARP1/ITGA4/FYN/LRP1/TLR6 5 GO:0050804 modulation of chemical synaptic transmission 29/1036 436/18670 0.1794 0.5676 0.5012 CD38/ABAT/IL1B/ATP2A2/KMO/EIF4A3/P2RX1/FYN/NTSR1/PLCL1/TNF/HRH2/DNM1L/CALB2/RARA/SLC8A2/PRKAR2B/JPH3/CHRM2/DBN1/CA7/NMU/RPL22/ADNP/GRIN2D/PSMC5/EFNB3/SLC1A3/BCR 29 GO:0046651 lymphocyte proliferation 19/1036 272/18670 0.1796 0.5676 0.5012 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/MALT1/NCK1/PRKCQ/IL12B/FYN/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/SATB1/CLC 19 GO:0007618 mating 4/1036 40/18670 0.1798 0.5676 0.5012 ABAT/UBE2Q1/P2RX1/HDAC4 4 GO:0045823 positive regulation of heart contraction 4/1036 40/18670 0.1798 0.5676 0.5012 ATP2A2/CHGA/KCNQ1/NMU 4 GO:0071526 semaphorin-plexin signaling pathway 4/1036 40/18670 0.1798 0.5676 0.5012 PLXNB2/SEMA4G/SEMA3G/SH3BP1 4 GO:0006986 response to unfolded protein 13/1036 176/18670 0.18 0.5676 0.5012 OPTN/NCK1/HSPA9/DERL1/ATF3/DNAJB1/XBP1/EDEM1/HSPE1/HSPA14/DAXX/PIK3R1/GFPT1 13 GO:0007059 chromosome segregation 22/1036 321/18670 0.1803 0.5676 0.5012 SFPQ/NUP37/AURKC/CDC23/ANAPC5/BEX4/SLC25A5/ZWINT/PSMG2/HIRA/CSNK2A2/PHB2/PUM1/NDC80/TNKS/RIOK2/FBXO5/RRS1/ATRX/PRC1/TERF1/SMC2 22 GO:0006268 DNA unwinding involved in DNA replication 2/1036 14/18670 0.1804 0.5676 0.5012 RPA1/MCM6 2 GO:0006896 Golgi to vacuole transport 2/1036 14/18670 0.1804 0.5676 0.5012 CCDC91/EHD3 2 GO:0006999 nuclear pore organization 2/1036 14/18670 0.1804 0.5676 0.5012 NUP107/NUP205 2 GO:0009214 cyclic nucleotide catabolic process 2/1036 14/18670 0.1804 0.5676 0.5012 PDE4B/PDE8A 2 GO:0010755 regulation of plasminogen activation 2/1036 14/18670 0.1804 0.5676 0.5012 PLGRKT/F12 2 GO:0014854 response to inactivity 2/1036 14/18670 0.1804 0.5676 0.5012 CAT/HDAC4 2 GO:0021692 cerebellar Purkinje cell layer morphogenesis 2/1036 14/18670 0.1804 0.5676 0.5012 RORA/HERC1 2 GO:0030213 hyaluronan biosynthetic process 2/1036 14/18670 0.1804 0.5676 0.5012 NFKB1/IL1B 2 GO:0032310 prostaglandin secretion 2/1036 14/18670 0.1804 0.5676 0.5012 IL1B/ABCC4 2 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 2/1036 14/18670 0.1804 0.5676 0.5012 ASXL2/CITED2 2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2/1036 14/18670 0.1804 0.5676 0.5012 LRP1/PDGFRL 2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 2/1036 14/18670 0.1804 0.5676 0.5012 PIK3CA/PIK3C2A 2 GO:0043173 nucleotide salvage 2/1036 14/18670 0.1804 0.5676 0.5012 UCKL1/APRT 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation 2/1036 14/18670 0.1804 0.5676 0.5012 GPR18/SATB1 2 GO:0043558 regulation of translational initiation in response to stress 2/1036 14/18670 0.1804 0.5676 0.5012 NCK1/NPM1 2 GO:0044546 NLRP3 inflammasome complex assembly 2/1036 14/18670 0.1804 0.5676 0.5012 TLR6/ATAT1 2 GO:0045064 T-helper 2 cell differentiation 2/1036 14/18670 0.1804 0.5676 0.5012 ANXA1/RARA 2 GO:0045591 positive regulation of regulatory T cell differentiation 2/1036 14/18670 0.1804 0.5676 0.5012 IFNG/LILRB4 2 GO:0046033 AMP metabolic process 2/1036 14/18670 0.1804 0.5676 0.5012 ADSL/APRT 2 GO:0046606 negative regulation of centrosome cycle 2/1036 14/18670 0.1804 0.5676 0.5012 TRIM37/NPM1 2 GO:0046940 nucleoside monophosphate phosphorylation 2/1036 14/18670 0.1804 0.5676 0.5012 AK6/CMPK1 2 GO:0048308 organelle inheritance 2/1036 14/18670 0.1804 0.5676 0.5012 MAPK3/VRK1 2 GO:0048313 Golgi inheritance 2/1036 14/18670 0.1804 0.5676 0.5012 MAPK3/VRK1 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2/1036 14/18670 0.1804 0.5676 0.5012 TRAT1/LCK 2 GO:0051852 disruption by host of symbiont cells 2/1036 14/18670 0.1804 0.5676 0.5012 ELANE/CTSG 2 GO:0051938 L-glutamate import 2/1036 14/18670 0.1804 0.5676 0.5012 NTSR1/SLC1A3 2 GO:0060452 positive regulation of cardiac muscle contraction 2/1036 14/18670 0.1804 0.5676 0.5012 CHGA/KCNQ1 2 GO:0060732 positive regulation of inositol phosphate biosynthetic process 2/1036 14/18670 0.1804 0.5676 0.5012 CD244/NTSR1 2 GO:0071361 cellular response to ethanol 2/1036 14/18670 0.1804 0.5676 0.5012 GLRA1/SPI1 2 GO:0071391 cellular response to estrogen stimulus 2/1036 14/18670 0.1804 0.5676 0.5012 RARA/TRIM24 2 GO:0071941 nitrogen cycle metabolic process 2/1036 14/18670 0.1804 0.5676 0.5012 OTC/CYP2C9 2 GO:0072216 positive regulation of metanephros development 2/1036 14/18670 0.1804 0.5676 0.5012 MYC/LIF 2 GO:0080009 mRNA methylation 2/1036 14/18670 0.1804 0.5676 0.5012 TRMT61B/CBLL1 2 GO:0086069 bundle of His cell to Purkinje myocyte communication 2/1036 14/18670 0.1804 0.5676 0.5012 SCN10A/RANGRF 2 GO:0090110 cargo loading into COPII-coated vesicle 2/1036 14/18670 0.1804 0.5676 0.5012 INSIG1/SEC24A 2 GO:0098543 detection of other organism 2/1036 14/18670 0.1804 0.5676 0.5012 TLR6/PGLYRP4 2 GO:1901722 regulation of cell proliferation involved in kidney development 2/1036 14/18670 0.1804 0.5676 0.5012 MYC/FLCN 2 GO:1904152 regulation of retrograde protein transport, ER to cytosol 2/1036 14/18670 0.1804 0.5676 0.5012 EDEM1/UBE2J1 2 GO:1905049 negative regulation of metallopeptidase activity 2/1036 14/18670 0.1804 0.5676 0.5012 RECK/TIMP2 2 GO:1905050 positive regulation of metallopeptidase activity 2/1036 14/18670 0.1804 0.5676 0.5012 MBP/MAPK3 2 GO:2001279 regulation of unsaturated fatty acid biosynthetic process 2/1036 14/18670 0.1804 0.5676 0.5012 IL1B/ANXA1 2 GO:0002688 regulation of leukocyte chemotaxis 9/1036 114/18670 0.182 0.5719 0.505 CCL5/IL6/C1QBP/GPR18/DAPK2/IL23A/MAPK3/SLAMF8/LBP 9 GO:0006690 icosanoid metabolic process 9/1036 114/18670 0.182 0.5719 0.505 IL1B/ANXA1/MAPK3/PON1/CYP2C9/AKR1C3/PLA2G3/CYP4A11/CYP4F12 9 GO:0071901 negative regulation of protein serine/threonine kinase activity 11/1036 145/18670 0.1822 0.5722 0.5053 AIDA/DUSP2/IL1B/STK38/PTPN22/CDK5RAP1/PRKAR2B/DUSP21/HEG1/PAQR3/IPO7 11 GO:0051056 regulation of small GTPase mediated signal transduction 23/1036 338/18670 0.1826 0.5728 0.5058 RHOH/AUTS2/ARHGEF3/SOS1/FLCN/GPR18/ARHGAP17/RASA1/ARHGAP4/CD2AP/RASGRP1/ARHGEF7/ARHGEF17/MYO9B/RALGAPA1/TIMP2/HEG1/LPAR6/ARHGEF28/SH3BP1/IQSEC3/P2RY10/BCR 23 GO:0099177 regulation of trans-synaptic signaling 29/1036 437/18670 0.1826 0.5728 0.5058 CD38/ABAT/IL1B/ATP2A2/KMO/EIF4A3/P2RX1/FYN/NTSR1/PLCL1/TNF/HRH2/DNM1L/CALB2/RARA/SLC8A2/PRKAR2B/JPH3/CHRM2/DBN1/CA7/NMU/RPL22/ADNP/GRIN2D/PSMC5/EFNB3/SLC1A3/BCR 29 GO:0050771 negative regulation of axonogenesis 6/1036 69/18670 0.1833 0.5741 0.507 ARHGAP4/MAP2/SEMA4G/SEMA3G/NTN1/EFNB3 6 GO:2000243 positive regulation of reproductive process 6/1036 69/18670 0.1833 0.5741 0.507 C1QBP/CDC25B/GLRA1/HDAC4/CITED2/SRY 6 GO:0061448 connective tissue development 19/1036 273/18670 0.1836 0.5749 0.5077 ARID5B/TGFBR2/OXCT1/GNAS/BMPR1B/MEX3C/XBP1/SULF1/RARA/PIK3CA/MAPK3/ZBTB16/OTOR/UBB/FGF18/ZNF516/SIX2/ACAT1/MAF 19 GO:0009914 hormone transport 22/1036 322/18670 0.184 0.5754 0.5081 CD38/ABAT/CCL5/IL6/IFNG/IL1B/OXCT1/PASK/UBE2Q1/GNAS/SLC25A5/DYNLL1/CHGA/CRY1/TNF/ANXA1/LRP1/TRH/LIF/AIMP1/GHRHR/NMU 22 GO:0032635 interleukin-6 production 12/1036 161/18670 0.184 0.5754 0.5081 SLAMF1/IL6/IL1B/TNF/PTPN22/IL36A/TLR3/XBP1/MBP/SPHK2/TLR6/LBP 12 GO:1905897 regulation of response to endoplasmic reticulum stress 7/1036 84/18670 0.1845 0.5762 0.5088 NCK1/USP25/XBP1/EDEM1/PMAIP1/PIK3R1/UBE2J1 7 GO:0033673 negative regulation of kinase activity 18/1036 257/18670 0.1845 0.5762 0.5088 AIDA/RHOH/IFNG/DUSP2/IL1B/NCK1/STK38/CBLB/COX11/PTPN22/TRIB2/CDK5RAP1/NPM1/PRKAR2B/DUSP21/HEG1/PAQR3/IPO7 18 GO:0003231 cardiac ventricle development 10/1036 130/18670 0.1856 0.5792 0.5115 TGFBR2/ACVR1/TNNI1/TGFBR3/SMARCD3/RBM15/CITED2/HEG1/AP2B1/FZD2 10 GO:1901654 response to ketone 14/1036 193/18670 0.1857 0.5793 0.5115 CD38/PCNA/PARP1/TGFBR3/RWDD1/FDX1/TRH/SPHK2/AKR1B1/PTGER4/AKR1C3/ADAM15/CA9/CATSPERG 14 GO:0003148 outflow tract septum morphogenesis 3/1036 27/18670 0.1869 0.5793 0.5115 TGFBR2/PARVA/RARA 3 GO:0006829 zinc ion transport 3/1036 27/18670 0.1869 0.5793 0.5115 TRPM2/SLC30A9/SLC39A6 3 GO:0009651 response to salt stress 3/1036 27/18670 0.1869 0.5793 0.5115 KMO/TNF/AKR1B1 3 GO:0032201 telomere maintenance via semi-conservative replication 3/1036 27/18670 0.1869 0.5793 0.5115 PCNA/RPA1/TERF1 3 GO:0036475 neuron death in response to oxidative stress 3/1036 27/18670 0.1869 0.5793 0.5115 PARP1/LANCL1/TLR6 3 GO:0043032 positive regulation of macrophage activation 3/1036 27/18670 0.1869 0.5793 0.5115 CTSC/TLR6/LBP 3 GO:0051953 negative regulation of amine transport 3/1036 27/18670 0.1869 0.5793 0.5115 ABAT/CHGA/TRH 3 GO:0071450 cellular response to oxygen radical 3/1036 27/18670 0.1869 0.5793 0.5115 SOD3/TNF/SOD1 3 GO:0071451 cellular response to superoxide 3/1036 27/18670 0.1869 0.5793 0.5115 SOD3/TNF/SOD1 3 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 3/1036 27/18670 0.1869 0.5793 0.5115 PARP1/SFPQ/SOD1 3 GO:1904357 negative regulation of telomere maintenance via telomere lengthening 3/1036 27/18670 0.1869 0.5793 0.5115 PARP1/TNKS/TERF1 3 GO:0032943 mononuclear cell proliferation 19/1036 274/18670 0.1878 0.5812 0.5132 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/MALT1/NCK1/PRKCQ/IL12B/FYN/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/SATB1/CLC 19 GO:0042542 response to hydrogen peroxide 11/1036 146/18670 0.1879 0.5812 0.5132 PCNA/IL6/CAT/HP/FYN/TRPM2/ANXA1/PDE8A/SETX/SOD1/CBX8 11 GO:1904892 regulation of STAT cascade 11/1036 146/18670 0.1879 0.5812 0.5132 CCL5/IL6/IFNG/IL12B/FYN/TNF/IL23A/LIF/AKR1B1/IL15/IL3 11 GO:2000241 regulation of reproductive process 11/1036 146/18670 0.1879 0.5812 0.5132 C1QBP/CDC25B/PRKACB/SULF1/GLRA1/LIF/HDAC4/STK11/CITED2/FBXO5/SRY 11 GO:0050708 regulation of protein secretion 31/1036 472/18670 0.1882 0.5816 0.5135 CD38/ABAT/IL1A/CCL5/IL6/IFNG/CD2/IL1B/OXCT1/SLC25A5/DYNLL1/CD244/CHGA/TNF/PTPN22/CD2AP/ANXA1/LRP1/RASGRP1/DNM1L/XBP1/MBP/RSAD2/TRH/MAPK3/PTGER4/TLR6/FCN1/NMU/SEC24A/ATG5 31 GO:0032781 positive regulation of ATPase activity 5/1036 55/18670 0.1885 0.5821 0.514 DNAJC9/DYNLL1/DNAJB1/ATP1B1/TOR1AIP1 5 GO:2000242 negative regulation of reproductive process 5/1036 55/18670 0.1885 0.5821 0.514 PRKACB/SULF1/LIF/STK11/FBXO5 5 GO:0010950 positive regulation of endopeptidase activity 13/1036 178/18670 0.1903 0.5872 0.5185 MYC/MALT1/CTSD/PSMD14/P2RX1/CYCS/FYN/TNF/CYFIP2/LCK/MBP/HSPE1/PMAIP1 13 GO:1903053 regulation of extracellular matrix organization 4/1036 41/18670 0.1911 0.5888 0.5199 IL6/LRP1/CLASP1/COLGALT1 4 GO:0009896 positive regulation of catabolic process 28/1036 423/18670 0.1912 0.5888 0.5199 OPTN/IL6/IFNG/RCHY1/IL1B/FLCN/DACT1/CTSC/SESN1/BTG2/ZFP36/PSMC2/GCLC/TNF/RBX1/NNT/TRIB2/LRP1/HNRNPR/EDEM1/PUM1/MAPK3/PABPC1/FYCO1/STK11/PSMD10/WAC/KHSRP 28 GO:0032386 regulation of intracellular transport 28/1036 423/18670 0.1912 0.5888 0.5199 IFNG/IL1B/INSIG1/LDLRAP1/ATP2A2/P2RX1/SCFD1/FYN/PPP1CC/ZFAND1/CSNK2A2/MAP2/EHD2/DNM1L/EDEM1/ICE1/MAPK3/SCP2/SPHK2/PCM1/CHRM2/RIOK2/HAX1/MFF/PIK3R1/UBE2J1/NUP214/FEZ1 28 GO:0010517 regulation of phospholipase activity 6/1036 70/18670 0.1918 0.5901 0.521 CCL5/TXK/ANXA1/ITK/LRP1/AVPR1B 6 GO:0034121 regulation of toll-like receptor signaling pathway 6/1036 70/18670 0.1918 0.5901 0.521 BIRC3/PTPN22/TLR3/RSAD2/TLR6/LBP 6 GO:0050772 positive regulation of axonogenesis 7/1036 85/18670 0.1921 0.5904 0.5214 PLXNB2/LRP1/STK11/DBN1/DSCAM/NTN1/ADNP 7 GO:0072384 organelle transport along microtubule 7/1036 85/18670 0.1921 0.5904 0.5214 KIFAP3/MAP2/RASGRP1/UXT/FYCO1/UBB/FEZ1 7 GO:0090257 regulation of muscle system process 18/1036 259/18670 0.1931 0.5929 0.5236 PARP1/ABAT/CLIC2/ATP2A2/P2RX1/HSPB6/CHGA/PDE4B/TNNI1/SCN10A/ATP1B1/HDAC4/CHRM2/RANGRF/EHD3/SOD1/KCNQ1/NMU 18 GO:0061351 neural precursor cell proliferation 11/1036 147/18670 0.1937 0.5943 0.5248 RORA/ORC3/BTG2/PLXNB2/ARTN/NAP1L1/SMARCD3/SPINT1/PCM1/DBN1/TMEM14B 11 GO:0071236 cellular response to antibiotic 11/1036 147/18670 0.1937 0.5943 0.5248 PCNA/IL6/TRPM2/ANXA1/FDX1/GLRA1/PDE8A/SPI1/DAXX/SETX/CBX8 11 GO:0005996 monosaccharide metabolic process 20/1036 292/18670 0.1947 0.5956 0.5259 DYRK2/MDH1/CREM/PGK1/DUSP12/PASK/RORA/GCLC/CRY1/COX11/TNF/ATF3/CLK2/PIK3CA/AKR1B1/HECTD4/PFKP/CYB5A/PMAIP1/PDHB 20 GO:0006304 DNA modification 9/1036 116/18670 0.1951 0.5956 0.5259 PARP1/MYC/GNAS/ASCC3/PIK3CA/APOBEC3G/SPI1/ATRX/METTL4 9 GO:0042177 negative regulation of protein catabolic process 10/1036 132/18670 0.1978 0.5956 0.5259 USP25/LAMP3/FYN/RPS7/CSNK2A2/TIMP2/TIMP4/WAC/RPL11/UBE2J1 10 GO:0052548 regulation of endopeptidase activity 28/1036 425/18670 0.1979 0.5956 0.5259 MYC/MALT1/WFDC1/LAMP3/CTSD/PSMD14/P2RX1/CYCS/FYN/MICAL1/BIRC3/TNF/SIAH2/RECK/CYFIP2/SPINT1/LCK/PEBP1/MBP/HSPE1/CST7/TIMP2/TIMP4/CSN2/IGBP1/PMAIP1/RPS6KA3/PSMA3 28 GO:0050830 defense response to Gram-positive bacterium 8/1036 101/18670 0.1979 0.5956 0.5259 DROSHA/IL6/LYZ/CHGA/TNF/CTSG/PGLYRP4/LBP 8 GO:0097006 regulation of plasma lipoprotein particle levels 8/1036 101/18670 0.1979 0.5956 0.5259 CETP/LIPA/PRKACB/LDLRAP1/NPC1/ACSL3/AP2B1/KHSRP 8 GO:0001912 positive regulation of leukocyte mediated cytotoxicity 5/1036 56/18670 0.1983 0.5956 0.5259 SH2D1A/IL12B/CD1A/RASGRP1/IL23A 5 GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response 5/1036 56/18670 0.1983 0.5956 0.5259 POU2F2/TNFSF13/HLA-DQB1/MSH2/TBX21 5 GO:0009435 NAD biosynthetic process 5/1036 56/18670 0.1983 0.5956 0.5259 PGK1/KMO/SLC22A13/KYNU/PFKP 5 GO:0060688 regulation of morphogenesis of a branching structure 5/1036 56/18670 0.1983 0.5956 0.5259 MAGED1/TNF/PHB2/SULF1/SIX2 5 GO:0072528 pyrimidine-containing compound biosynthetic process 5/1036 56/18670 0.1983 0.5956 0.5259 DCK/CMPK1/PRPS1/UCKL1/AGPAT2 5 GO:1902017 regulation of cilium assembly 5/1036 56/18670 0.1983 0.5956 0.5259 ATMIN/DYNLL1/VDAC3/ZMYND10/ATG5 5 GO:0051896 regulation of protein kinase B signaling 17/1036 244/18670 0.1986 0.5956 0.5259 TRAT1/C1QBP/FLCN/PPP2R5C/RRAS/ICOS/FYN/ERBB3/TNF/LCK/PIK3CA/STK11/AKR1C3/HAX1/FGF18/PIK3R1/RCN3 17 GO:0072001 renal system development 20/1036 293/18670 0.1988 0.5956 0.5259 ARID5B/MYC/NUP107/FLCN/CAT/ITGA6/ODC1/MAGED1/HSPB11/PRKX/SULF1/RARA/NUP85/LIF/AKR1B1/ZBTB16/ITGB4/NUP160/SIX2/ACAT1 20 GO:0061041 regulation of wound healing 11/1036 148/18670 0.1996 0.5956 0.5259 ABAT/TGFBR2/ENPP4/WFDC1/PRKCQ/F12/CXCR4/ANXA1/XBP1/CLASP1/CD9 11 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 7/1036 86/18670 0.1999 0.5956 0.5259 MOAP1/TNF/ATF3/BMPR1B/DAXX/PMAIP1/PIK3R1 7 GO:0090559 regulation of membrane permeability 7/1036 86/18670 0.1999 0.5956 0.5259 MOAP1/SLC25A5/GZMB/YWHAQ/HEG1/PMAIP1/SLC35F6 7 GO:1903363 negative regulation of cellular protein catabolic process 7/1036 86/18670 0.1999 0.5956 0.5259 USP25/LAMP3/RPS7/CSNK2A2/WAC/RPL11/UBE2J1 7 GO:0051057 positive regulation of small GTPase mediated signal transduction 6/1036 71/18670 0.2004 0.5956 0.5259 AUTS2/SOS1/GPR18/RASGRP1/LPAR6/P2RY10 6 GO:0007088 regulation of mitotic nuclear division 12/1036 164/18670 0.2005 0.5956 0.5259 IL1A/IL1B/CDC23/ANAPC5/PSMG2/PHB2/NDC80/TNKS/RIOK2/FBXO5/PKMYT1/ATRX 12 GO:0071346 cellular response to interferon-gamma 13/1036 180/18670 0.2009 0.5956 0.5259 HLA-DRB4/CCL5/IFNG/TRIM68/IL12B/HLA-DQB1/WAS/TXK/STX8/TLR3/CCL11/CCL25/CCL23 13 GO:0000098 sulfur amino acid catabolic process 2/1036 15/18670 0.201 0.5956 0.5259 ADO/CBS 2 GO:0001829 trophectodermal cell differentiation 2/1036 15/18670 0.201 0.5956 0.5259 CTR9/HOPX 2 GO:0009415 response to water 2/1036 15/18670 0.201 0.5956 0.5259 AKR1B1/CD9 2 GO:0010455 positive regulation of cell fate commitment 2/1036 15/18670 0.201 0.5956 0.5259 IL12B/IL23A 2 GO:0010759 positive regulation of macrophage chemotaxis 2/1036 15/18670 0.201 0.5956 0.5259 CCL5/MAPK3 2 GO:0015671 oxygen transport 2/1036 15/18670 0.201 0.5956 0.5259 MYC/IPCEF1 2 GO:0015936 coenzyme A metabolic process 2/1036 15/18670 0.201 0.5956 0.5259 PPCS/ACAT1 2 GO:0030730 sequestering of triglyceride 2/1036 15/18670 0.201 0.5956 0.5259 IL1B/TNF 2 GO:0030852 regulation of granulocyte differentiation 2/1036 15/18670 0.201 0.5956 0.5259 RARA/HAX1 2 GO:0031054 pre-miRNA processing 2/1036 15/18670 0.201 0.5956 0.5259 DROSHA/PRKRA 2 GO:0033604 negative regulation of catecholamine secretion 2/1036 15/18670 0.201 0.5956 0.5259 ABAT/CHGA 2 GO:0034111 negative regulation of homotypic cell-cell adhesion 2/1036 15/18670 0.201 0.5956 0.5259 ABAT/CD9 2 GO:0034310 primary alcohol catabolic process 2/1036 15/18670 0.201 0.5956 0.5259 AKR1C3/ALDH3B1 2 GO:0035067 negative regulation of histone acetylation 2/1036 15/18670 0.201 0.5956 0.5259 SPI1/ATG5 2 GO:0035635 entry of bacterium into host cell 2/1036 15/18670 0.201 0.5956 0.5259 EXOC7/CBLL1 2 GO:0042754 negative regulation of circadian rhythm 2/1036 15/18670 0.201 0.5956 0.5259 SFPQ/CRY1 2 GO:0043101 purine-containing compound salvage 2/1036 15/18670 0.201 0.5956 0.5259 DCK/APRT 2 GO:0043508 negative regulation of JUN kinase activity 2/1036 15/18670 0.201 0.5956 0.5259 AIDA/PTPN22 2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly 2/1036 15/18670 0.201 0.5956 0.5259 PSMC2/PSMC5 2 GO:0046851 negative regulation of bone remodeling 2/1036 15/18670 0.201 0.5956 0.5259 CD38/IL6 2 GO:0048569 post-embryonic animal organ development 2/1036 15/18670 0.201 0.5956 0.5259 BCL11B/HMGN1 2 GO:0050961 detection of temperature stimulus involved in sensory perception 2/1036 15/18670 0.201 0.5956 0.5259 NTSR1/CXCR4 2 GO:0050965 detection of temperature stimulus involved in sensory perception of pain 2/1036 15/18670 0.201 0.5956 0.5259 NTSR1/CXCR4 2 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/1036 15/18670 0.201 0.5956 0.5259 CLIC2/NTSR1 2 GO:0051883 killing of cells in other organism involved in symbiotic interaction 2/1036 15/18670 0.201 0.5956 0.5259 ELANE/CTSG 2 GO:0060766 negative regulation of androgen receptor signaling pathway 2/1036 15/18670 0.201 0.5956 0.5259 NCOR1/ZBTB7A 2 GO:0072148 epithelial cell fate commitment 2/1036 15/18670 0.201 0.5956 0.5259 ACVR1/RARA 2 GO:0072283 metanephric renal vesicle morphogenesis 2/1036 15/18670 0.201 0.5956 0.5259 LIF/SIX2 2 GO:0097428 protein maturation by iron-sulfur cluster transfer 2/1036 15/18670 0.201 0.5956 0.5259 ISCA1/NFU1 2 GO:1903358 regulation of Golgi organization 2/1036 15/18670 0.201 0.5956 0.5259 MAPK3/EHD3 2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 2/1036 15/18670 0.201 0.5956 0.5259 DACT1/MLLT3 2 GO:0001516 prostaglandin biosynthetic process 3/1036 28/18670 0.2013 0.5956 0.5259 IL1B/ANXA1/AKR1C3 3 GO:0009074 aromatic amino acid family catabolic process 3/1036 28/18670 0.2013 0.5956 0.5259 KMO/QDPR/KYNU 3 GO:0010818 T cell chemotaxis 3/1036 28/18670 0.2013 0.5956 0.5259 CXCL11/CCL5/GPR183 3 GO:0010894 negative regulation of steroid biosynthetic process 3/1036 28/18670 0.2013 0.5956 0.5259 NFKB1/INSIG1/SOD1 3 GO:0032770 positive regulation of monooxygenase activity 3/1036 28/18670 0.2013 0.5956 0.5259 IFNG/IL1B/TNF 3 GO:0033137 negative regulation of peptidyl-serine phosphorylation 3/1036 28/18670 0.2013 0.5956 0.5259 NCK1/GPD1L/PAQR3 3 GO:0043501 skeletal muscle adaptation 3/1036 28/18670 0.2013 0.5956 0.5259 ATP2A2/TNNI1/IL15 3 GO:0045408 regulation of interleukin-6 biosynthetic process 3/1036 28/18670 0.2013 0.5956 0.5259 IL1B/TNF/TLR6 3 GO:0046457 prostanoid biosynthetic process 3/1036 28/18670 0.2013 0.5956 0.5259 IL1B/ANXA1/AKR1C3 3 GO:0070861 regulation of protein exit from endoplasmic reticulum 3/1036 28/18670 0.2013 0.5956 0.5259 INSIG1/EDEM1/UBE2J1 3 GO:1900543 negative regulation of purine nucleotide metabolic process 3/1036 28/18670 0.2013 0.5956 0.5259 PARP1/FLCN/HDAC4 3 GO:1902745 positive regulation of lamellipodium organization 3/1036 28/18670 0.2013 0.5956 0.5259 AUTS2/ARHGEF7/HDAC4 3 GO:0010822 positive regulation of mitochondrion organization 9/1036 117/18670 0.2017 0.5963 0.5265 OPTN/DDHD2/MOAP1/GZMB/CSNK2A2/YWHAQ/DNM1L/PMAIP1/MFF 9 GO:0031398 positive regulation of protein ubiquitination 9/1036 117/18670 0.2017 0.5963 0.5265 RCHY1/CTR9/MALT1/DERL1/CRY1/BIRC3/PTPN22/PSMD10/UBB 9 GO:0006654 phosphatidic acid biosynthetic process 4/1036 42/18670 0.2027 0.5978 0.5279 DDHD2/GPD1L/DGKZ/AGPAT2 4 GO:0032958 inositol phosphate biosynthetic process 4/1036 42/18670 0.2027 0.5978 0.5279 CD244/NTSR1/PLCL1/PLCB3 4 GO:0042149 cellular response to glucose starvation 4/1036 42/18670 0.2027 0.5978 0.5279 ATG14/SESN1/XBP1/PMAIP1 4 GO:1903146 regulation of autophagy of mitochondrion 4/1036 42/18670 0.2027 0.5978 0.5279 OPTN/CSNK2A2/DNM1L/HAX1 4 GO:0035335 peptidyl-tyrosine dephosphorylation 8/1036 102/18670 0.2052 0.6048 0.534 PTPN4/DUSP2/DUSP12/CDC25B/PTPN22/PTPN7/DUSP21/DUSP13 8 GO:2001056 positive regulation of cysteine-type endopeptidase activity 11/1036 149/18670 0.2055 0.6054 0.5346 MYC/MALT1/CTSD/P2RX1/CYCS/FYN/TNF/CYFIP2/LCK/HSPE1/PMAIP1 11 GO:0016236 macroautophagy 20/1036 295/18670 0.2072 0.61 0.5386 OPTN/ATG14/LGALS8/CAPN1/NPC1/SESN1/DYNLL1/SCFD1/MFN1/CSNK2A2/EXOC7/PIK3CA/MAPK3/FYCO1/VPS37B/TOMM20/WAC/MCOLN1/ATG5/FEZ1 20 GO:0002690 positive regulation of leukocyte chemotaxis 7/1036 87/18670 0.2079 0.6117 0.5401 CCL5/IL6/C1QBP/DAPK2/IL23A/MAPK3/LBP 7 GO:1901799 negative regulation of proteasomal protein catabolic process 5/1036 57/18670 0.2082 0.6125 0.5408 USP25/LAMP3/WAC/RPL11/UBE2J1 5 GO:0042471 ear morphogenesis 9/1036 118/18670 0.2085 0.6128 0.5412 INSIG1/LRIG1/PRKRA/MAPK3/SOD1/NTN1/SIX2/FZD2/BCR 9 GO:0000082 G1/S transition of mitotic cell cycle 19/1036 279/18670 0.209 0.613 0.5413 PCNA/MYC/BRD7/DACT1/ORC3/BTG2/ACVR1/ANKRD17/ORC2/ANXA1/GMNN/FBXO5/CUL1/ORC4/GSPT1/RPA1/CDC7/TMEM14B/MCM6 19 GO:0002532 production of molecular mediator involved in inflammatory response 6/1036 72/18670 0.2092 0.613 0.5413 CD96/P2RX1/TLR6/SLAMF8/IL17B/LBP 6 GO:0032024 positive regulation of insulin secretion 6/1036 72/18670 0.2092 0.613 0.5413 CD38/ABAT/OXCT1/DYNLL1/LRP1/TRH 6 GO:0038034 signal transduction in absence of ligand 6/1036 72/18670 0.2092 0.613 0.5413 IL1A/IL1B/MOAP1/FYN/ERBB3/TNF 6 GO:0061035 regulation of cartilage development 6/1036 72/18670 0.2092 0.613 0.5413 BMPR1B/RARA/ZBTB16/FGF18/SIX2/MAF 6 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 6/1036 72/18670 0.2092 0.613 0.5413 IL1A/IL1B/MOAP1/FYN/ERBB3/TNF 6 GO:0008217 regulation of blood pressure 13/1036 182/18670 0.2117 0.6198 0.5473 ABAT/HSD11B2/P2RX1/CHGA/NTSR1/EMP2/PLCB3/AVPR1B/SOD1/NMU/CTSG/CYP4A11/CYP4F12 13 GO:0007229 integrin-mediated signaling pathway 8/1036 103/18670 0.2125 0.621 0.5484 MADCAM1/ITGA4/ITGA6/ITGA7/EMP2/ITGB4/ADAM15/ITGAE 8 GO:0035601 protein deacylation 8/1036 103/18670 0.2125 0.621 0.5484 IFNG/SFPQ/BEX4/FNTA/SPHK2/HDAC4/DYRK1A/ZNHIT1 8 GO:1905269 positive regulation of chromatin organization 8/1036 103/18670 0.2125 0.621 0.5484 AUTS2/BRD7/CTR9/IL1B/SART3/MAPK3/LIF/SPHK2 8 GO:0000413 protein peptidyl-prolyl isomerization 4/1036 43/18670 0.2144 0.621 0.5484 FKBP8/FKBP11/FKBP3/FKBP10 4 GO:0001953 negative regulation of cell-matrix adhesion 4/1036 43/18670 0.2144 0.621 0.5484 RASA1/LRP1/ADAM15/PIK3R1 4 GO:0009163 nucleoside biosynthetic process 4/1036 43/18670 0.2144 0.621 0.5484 DCK/CMPK1/UCKL1/APRT 4 GO:0034198 cellular response to amino acid starvation 4/1036 43/18670 0.2144 0.621 0.5484 SESN1/ATF3/MAPK3/SLC38A2 4 GO:0038202 TORC1 signaling 4/1036 43/18670 0.2144 0.621 0.5484 FLCN/SESN1/STK11/DYRK3 4 GO:0042088 T-helper 1 type immune response 4/1036 43/18670 0.2144 0.621 0.5484 IL1B/IL12B/ANXA1/IL23A 4 GO:0046473 phosphatidic acid metabolic process 4/1036 43/18670 0.2144 0.621 0.5484 DDHD2/GPD1L/DGKZ/AGPAT2 4 GO:1901658 glycosyl compound catabolic process 4/1036 43/18670 0.2144 0.621 0.5484 DERA/ENPP4/AHCY/APOBEC3G 4 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 15/1036 215/18670 0.2152 0.621 0.5484 MYC/MALT1/LAMP3/CTSD/P2RX1/CYCS/MICAL1/BIRC3/TNF/SIAH2/LCK/HSPE1/IGBP1/PMAIP1/RPS6KA3 15 GO:0007173 epidermal growth factor receptor signaling pathway 9/1036 119/18670 0.2153 0.621 0.5484 SOS1/CBLB/ARHGEF7/PIK3CA/EPS15L1/PIK3C2A/DOK1/RNF115/PIK3R1 9 GO:0001655 urogenital system development 22/1036 330/18670 0.2154 0.621 0.5484 ARID5B/MYC/NUP107/FLCN/CAT/ITGA6/ODC1/MAGED1/HSPB11/ANXA1/PRKX/SULF1/RARA/NUP85/LIF/AKR1B1/STK11/ZBTB16/ITGB4/NUP160/SIX2/ACAT1 22 GO:1903522 regulation of blood circulation 20/1036 297/18670 0.2157 0.621 0.5484 CD38/CLIC2/ATP2A2/P2RX1/CHGA/PDE4B/SCN10A/HRH2/SLC8A2/GPD1L/ATP1B1/HDAC4/AVPR1B/CHRM2/CACNB4/RANGRF/ATP2B2/EHD3/KCNQ1/NMU 20 GO:0009791 post-embryonic development 7/1036 88/18670 0.2159 0.621 0.5484 ARID5B/GNAS/BCL11B/HMGN1/HEG1/DSCAM/ATRX 7 GO:0043506 regulation of JUN kinase activity 7/1036 88/18670 0.2159 0.621 0.5484 AIDA/TNF/PTPN22/MAP4K5/MAP4K2/TLR6/DAXX 7 GO:1902476 chloride transmembrane transport 7/1036 88/18670 0.2159 0.621 0.5484 CLIC2/SLC12A5/BEST1/GLRA1/GABRB2/GABRP/SLC1A3 7 GO:1904035 regulation of epithelial cell apoptotic process 7/1036 88/18670 0.2159 0.621 0.5484 IL6/ITGA4/ZFP36/TNF/TIA1/PIAS4/AKR1C3 7 GO:0000303 response to superoxide 3/1036 29/18670 0.2159 0.621 0.5484 SOD3/TNF/SOD1 3 GO:0006929 substrate-dependent cell migration 3/1036 29/18670 0.2159 0.621 0.5484 NCK1/CD2AP/NTN1 3 GO:0008299 isoprenoid biosynthetic process 3/1036 29/18670 0.2159 0.621 0.5484 PDSS1/IDI1/AKR1C3 3 GO:0010954 positive regulation of protein processing 3/1036 29/18670 0.2159 0.621 0.5484 IL1B/PLGRKT/F12 3 GO:0016056 rhodopsin mediated signaling pathway 3/1036 29/18670 0.2159 0.621 0.5484 METAP1/FNTA/METAP2 3 GO:0030970 retrograde protein transport, ER to cytosol 3/1036 29/18670 0.2159 0.621 0.5484 DERL1/EDEM1/UBE2J1 3 GO:0035025 positive regulation of Rho protein signal transduction 3/1036 29/18670 0.2159 0.621 0.5484 GPR18/LPAR6/P2RY10 3 GO:0042226 interleukin-6 biosynthetic process 3/1036 29/18670 0.2159 0.621 0.5484 IL1B/TNF/TLR6 3 GO:0045980 negative regulation of nucleotide metabolic process 3/1036 29/18670 0.2159 0.621 0.5484 PARP1/FLCN/HDAC4 3 GO:0046134 pyrimidine nucleoside biosynthetic process 3/1036 29/18670 0.2159 0.621 0.5484 DCK/CMPK1/UCKL1 3 GO:0050974 detection of mechanical stimulus involved in sensory perception 3/1036 29/18670 0.2159 0.621 0.5484 PIEZO2/FYN/CXCR4 3 GO:0060632 regulation of microtubule-based movement 3/1036 29/18670 0.2159 0.621 0.5484 MAP2/IGBP1/FEZ1 3 GO:0070102 interleukin-6-mediated signaling pathway 3/1036 29/18670 0.2159 0.621 0.5484 IL6/CTR9/SPI1 3 GO:1903513 endoplasmic reticulum to cytosol transport 3/1036 29/18670 0.2159 0.621 0.5484 DERL1/EDEM1/UBE2J1 3 GO:0034341 response to interferon-gamma 14/1036 199/18670 0.2163 0.6216 0.5489 HLA-DRB4/CCL5/IFNG/TRIM68/IL12B/HLA-DQB1/WAS/TXK/STX8/TLR3/KYNU/CCL11/CCL25/CCL23 14 GO:0035966 response to topologically incorrect protein 14/1036 199/18670 0.2163 0.6216 0.5489 OPTN/NCK1/HSPA9/DERL1/F12/ATF3/DNAJB1/XBP1/EDEM1/HSPE1/HSPA14/DAXX/PIK3R1/GFPT1 14 GO:1903169 regulation of calcium ion transmembrane transport 11/1036 151/18670 0.2176 0.623 0.5502 CXCL11/CLIC2/FYN/NTSR1/PDE4B/ATP1B1/JPH3/CACNB4/TSPAN13/EHD3/ATG5 11 GO:0002312 B cell activation involved in immune response 6/1036 73/18670 0.2181 0.623 0.5502 ITM2A/TNFSF13/MSH2/TBX21/XBP1/GPR183 6 GO:1903779 regulation of cardiac conduction 6/1036 73/18670 0.2181 0.623 0.5502 ATP2A2/SLC8A2/ATP1B1/RANGRF/ATP2B2/EHD3 6 GO:0055081 anion homeostasis 5/1036 58/18670 0.2183 0.623 0.5502 CETP/SLC12A5/XBP1/OTC/RCN3 5 GO:0061951 establishment of protein localization to plasma membrane 5/1036 58/18670 0.2183 0.623 0.5502 OPTN/GORASP2/ANXA13/C16orf70/ACSL3 5 GO:0009314 response to radiation 29/1036 448/18670 0.2197 0.623 0.5502 PCNA/PARP1/DDHD2/MYC/TOPBP1/METAP1/CAT/IL12B/CRY1/PPP1CC/FNTA/USP1/ANXA1/MSH2/HRH2/CLK2/BEST1/ATR/METAP2/NPM1/HMGN1/ELANE/STK11/CCL11/NMU/TRPM1/XRCC2/PIK3R1/SLC1A3 29 GO:0019233 sensory perception of pain 8/1036 104/18670 0.2199 0.623 0.5502 IL12B/FYN/NTSR1/SCN10A/CXCR4/MAPK3/NMU/GRIN2D 8 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/1036 104/18670 0.2199 0.623 0.5502 FKBP8/PARP1/FLCN/ACVR1/TGFBR3/SULF1/STK11/CITED2 8 GO:0098732 macromolecule deacylation 8/1036 104/18670 0.2199 0.623 0.5502 IFNG/SFPQ/BEX4/FNTA/SPHK2/HDAC4/DYRK1A/ZNHIT1 8 GO:0044843 cell cycle G1/S phase transition 20/1036 298/18670 0.22 0.623 0.5502 PCNA/MYC/BRD7/DACT1/ORC3/BTG2/ACVR1/ANKRD17/ORC2/ANXA1/PHB2/GMNN/FBXO5/CUL1/ORC4/GSPT1/RPA1/CDC7/TMEM14B/MCM6 20 GO:0003012 muscle system process 30/1036 465/18670 0.2204 0.623 0.5502 CD38/PARP1/SYNM/ABAT/IL1B/CLIC2/MYL1/ATP2A2/LTB4R/P2RX1/HSPB6/CHGA/PDE4B/TNNI1/SCN10A/CXCR4/SULF1/GLRA1/PIK3CA/GPD1L/ATP1B1/HDAC4/CHRM2/PIK3C2A/P2RX6/IL15/EHD3/SOD1/KCNQ1/NMU 30 GO:0000076 DNA replication checkpoint 2/1036 16/18670 0.2217 0.623 0.5502 NAE1/TOPBP1 2 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process 2/1036 16/18670 0.2217 0.623 0.5502 CMPK1/UCKL1 2 GO:0010875 positive regulation of cholesterol efflux 2/1036 16/18670 0.2217 0.623 0.5502 LRP1/PON1 2 GO:0010919 regulation of inositol phosphate biosynthetic process 2/1036 16/18670 0.2217 0.623 0.5502 CD244/NTSR1 2 GO:0016540 protein autoprocessing 2/1036 16/18670 0.2217 0.623 0.5502 PARP1/F12 2 GO:0019372 lipoxygenase pathway 2/1036 16/18670 0.2217 0.623 0.5502 PON1/PLA2G3 2 GO:0021542 dentate gyrus development 2/1036 16/18670 0.2217 0.623 0.5502 BTG2/ATAT1 2 GO:0032354 response to follicle-stimulating hormone 2/1036 16/18670 0.2217 0.623 0.5502 GCLC/TGFBR3 2 GO:0043217 myelin maintenance 2/1036 16/18670 0.2217 0.623 0.5502 CXCR4/SOD1 2 GO:0043981 histone H4-K5 acetylation 2/1036 16/18670 0.2217 0.623 0.5502 KANSL2/KAT8 2 GO:0043982 histone H4-K8 acetylation 2/1036 16/18670 0.2217 0.623 0.5502 KANSL2/KAT8 2 GO:0044065 regulation of respiratory system process 2/1036 16/18670 0.2217 0.623 0.5502 GLRA1/TLX3 2 GO:0044849 estrous cycle 2/1036 16/18670 0.2217 0.623 0.5502 PCNA/ADNP 2 GO:0045618 positive regulation of keratinocyte differentiation 2/1036 16/18670 0.2217 0.623 0.5502 PRKCH/NCOA3 2 GO:0045623 negative regulation of T-helper cell differentiation 2/1036 16/18670 0.2217 0.623 0.5502 ANXA1/TBX21 2 GO:0045989 positive regulation of striated muscle contraction 2/1036 16/18670 0.2217 0.623 0.5502 CHGA/KCNQ1 2 GO:0048385 regulation of retinoic acid receptor signaling pathway 2/1036 16/18670 0.2217 0.623 0.5502 NR2C1/AKR1C3 2 GO:0051571 positive regulation of histone H3-K4 methylation 2/1036 16/18670 0.2217 0.623 0.5502 AUTS2/CTR9 2 GO:0055012 ventricular cardiac muscle cell differentiation 2/1036 16/18670 0.2217 0.623 0.5502 RARA/ATG5 2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport 2/1036 16/18670 0.2217 0.623 0.5502 INSIG1/SCFD1 2 GO:0060965 negative regulation of gene silencing by miRNA 2/1036 16/18670 0.2217 0.623 0.5502 ELAVL1/NCOR1 2 GO:0061158 3'-UTR-mediated mRNA destabilization 2/1036 16/18670 0.2217 0.623 0.5502 ZFP36/KHSRP 2 GO:0070293 renal absorption 2/1036 16/18670 0.2217 0.623 0.5502 AKR1C3/KCNQ1 2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade 2/1036 16/18670 0.2217 0.623 0.5502 ERBB3/TNF 2 GO:0071871 response to epinephrine 2/1036 16/18670 0.2217 0.623 0.5502 PDE4B/KCNQ1 2 GO:0090036 regulation of protein kinase C signaling 2/1036 16/18670 0.2217 0.623 0.5502 GPD1L/SPHK2 2 GO:0090153 regulation of sphingolipid biosynthetic process 2/1036 16/18670 0.2217 0.623 0.5502 TNF/SPHK2 2 GO:0106058 positive regulation of calcineurin-mediated signaling 2/1036 16/18670 0.2217 0.623 0.5502 ERBB3/TNF 2 GO:1902004 positive regulation of amyloid-beta formation 2/1036 16/18670 0.2217 0.623 0.5502 IFNG/TNF 2 GO:1905038 regulation of membrane lipid metabolic process 2/1036 16/18670 0.2217 0.623 0.5502 TNF/SPHK2 2 GO:2000303 regulation of ceramide biosynthetic process 2/1036 16/18670 0.2217 0.623 0.5502 TNF/SPHK2 2 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 9/1036 120/18670 0.2223 0.6242 0.5512 TGFBR2/FLCN/HTRA1/TGFBR3/UBA52/STK11/CITED2/UBB/ZBTB7A 9 GO:0032675 regulation of interleukin-6 production 11/1036 152/18670 0.2238 0.628 0.5546 SLAMF1/IL6/IL1B/TNF/PTPN22/IL36A/TLR3/XBP1/MBP/TLR6/LBP 11 GO:0097306 cellular response to alcohol 7/1036 89/18670 0.224 0.6285 0.555 FDX1/GLRA1/SPHK2/PTGER4/SPI1/AKR1C3/ADAM15 7 GO:0006378 mRNA polyadenylation 4/1036 44/18670 0.2264 0.6327 0.5587 CTR9/PCF11/NUDT21/PABPC1 4 GO:0030225 macrophage differentiation 4/1036 44/18670 0.2264 0.6327 0.5587 PARP1/LIF/SPI1/IL15 4 GO:0046688 response to copper ion 4/1036 44/18670 0.2264 0.6327 0.5587 IL1A/SOD3/DAXX/SOD1 4 GO:0060999 positive regulation of dendritic spine development 4/1036 44/18670 0.2264 0.6327 0.5587 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:0061001 regulation of dendritic spine morphogenesis 4/1036 44/18670 0.2264 0.6327 0.5587 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:0070266 necroptotic process 4/1036 44/18670 0.2264 0.6327 0.5587 BIRC3/TNF/DNM1L/TLR3 4 GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/1036 44/18670 0.2264 0.6327 0.5587 NCK1/USP25/XBP1/UBE2J1 4 GO:0009064 glutamine family amino acid metabolic process 6/1036 74/18670 0.2272 0.634 0.5598 GCLC/OTC/ASNSD1/GAD2/SLC1A3/GFPT1 6 GO:0030104 water homeostasis 6/1036 74/18670 0.2272 0.634 0.5598 PRKACB/PRKAR2B/AKR1B1/GHRHR/CYP4A11/CYP4F12 6 GO:0086001 cardiac muscle cell action potential 6/1036 74/18670 0.2272 0.634 0.5598 ATP2A2/SCN10A/GPD1L/ATP1B1/RANGRF/KCNQ1 6 GO:0001836 release of cytochrome c from mitochondria 5/1036 59/18670 0.2286 0.6364 0.5619 MOAP1/DNM1L/PSMD10/PMAIP1/MFF 5 GO:0008333 endosome to lysosome transport 5/1036 59/18670 0.2286 0.6364 0.5619 ATG14/GPRASP1/STX8/HMGXB4/DENND3 5 GO:0070527 platelet aggregation 5/1036 59/18670 0.2286 0.6364 0.5619 ABAT/METAP1/PRKCQ/GNAS/CD9 5 GO:1902369 negative regulation of RNA catabolic process 5/1036 59/18670 0.2286 0.6364 0.5619 HNRNPA0/ZFP36/PAIP1/ELAVL1/PABPC1 5 GO:0070372 regulation of ERK1 and ERK2 cascade 20/1036 300/18670 0.2287 0.6364 0.5619 SLAMF1/CCL5/RANBP9/IL1B/FLCN/RRAS/TNF/PTPN22/ATF3/PHB2/LRP1/RASGRP1/MAPK3/LIF/PDE8A/CCL11/GPR183/CCL25/FGF18/CCL23 20 GO:0048660 regulation of smooth muscle cell proliferation 12/1036 169/18670 0.2294 0.6364 0.5619 CCL5/IL6/IFNG/TGFBR2/LDLRAP1/IL12B/TNF/ELANE/HDAC4/AKR1B1/ABCC4/IL15 12 GO:0051100 negative regulation of binding 12/1036 169/18670 0.2294 0.6364 0.5619 DACT1/ITGA4/EIF4A3/IFIT2/GZMA/MAP2/MAPK3/TNKS/ADAM15/ADNP/CCL23/CRMP1 12 GO:0140056 organelle localization by membrane tethering 12/1036 169/18670 0.2294 0.6364 0.5619 ATG14/ESYT1/CEP57/DYNLL1/SCFD1/STX10/STX8/PRKAR2B/HAUS2/PCM1/CEP76/CLASP1 12 GO:0061458 reproductive system development 28/1036 434/18670 0.2298 0.6364 0.5619 ARID5B/NUP107/PTX3/UBE2Q1/HTRA1/LHX3/BMPR1B/ANXA1/MSH2/SPINT1/TLR3/SULF1/RARA/TSPY1/MAPK3/LIF/RBM15/STK11/CITED2/AKR1C3/AMHR2/SRY/BPTF/UBB/SOD1/ATRX/ADAM15/TMED2 28 GO:0062013 positive regulation of small molecule metabolic process 11/1036 153/18670 0.23 0.6364 0.5619 DYRK2/NFKB1/PGK1/IFNG/IL1B/LDLRAP1/CD244/NTSR1/TNF/ANXA1/PMAIP1 11 GO:0090316 positive regulation of intracellular protein transport 11/1036 153/18670 0.23 0.6364 0.5619 IFNG/IL1B/FYN/ZFAND1/CSNK2A2/EDEM1/ICE1/PCM1/RIOK2/MFF/PIK3R1 11 GO:0072655 establishment of protein localization to mitochondrion 10/1036 137/18670 0.23 0.6364 0.5619 MOAP1/GZMB/CSNK2A2/YWHAQ/OXA1L/AGK/TOMM20/PMAIP1/HAX1/MFF 10 GO:0000305 response to oxygen radical 3/1036 30/18670 0.2308 0.6364 0.5619 SOD3/TNF/SOD1 3 GO:0003209 cardiac atrium morphogenesis 3/1036 30/18670 0.2308 0.6364 0.5619 SOS1/ACVR1/HEG1 3 GO:0010743 regulation of macrophage derived foam cell differentiation 3/1036 30/18670 0.2308 0.6364 0.5619 NFKB1/PRKCH/CETP 3 GO:0034472 snRNA 3'-end processing 3/1036 30/18670 0.2308 0.6364 0.5619 INTS12/INTS8/EXOSC8 3 GO:0044818 mitotic G2/M transition checkpoint 3/1036 30/18670 0.2308 0.6364 0.5619 NAE1/TOPBP1/DONSON 3 GO:0045939 negative regulation of steroid metabolic process 3/1036 30/18670 0.2308 0.6364 0.5619 NFKB1/INSIG1/SOD1 3 GO:0045948 positive regulation of translational initiation 3/1036 30/18670 0.2308 0.6364 0.5619 CCL5/NCK1/TNF 3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 3/1036 30/18670 0.2308 0.6364 0.5619 SH2D1A/IL12B/RASGRP1 3 GO:0061082 myeloid leukocyte cytokine production 3/1036 30/18670 0.2308 0.6364 0.5619 CHGA/DDX1/DDX21 3 GO:0070979 protein K11-linked ubiquitination 3/1036 30/18670 0.2308 0.6364 0.5619 CDC23/ANAPC5/RNF4 3 GO:1904292 regulation of ERAD pathway 3/1036 30/18670 0.2308 0.6364 0.5619 USP25/EDEM1/UBE2J1 3 GO:0001843 neural tube closure 7/1036 90/18670 0.2323 0.6395 0.5647 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0045778 positive regulation of ossification 7/1036 90/18670 0.2323 0.6395 0.5647 IL6/GNAS/ACVR1/BMPR1B/PDLIM7/FBXO5/ZBTB16 7 GO:0051304 chromosome separation 7/1036 90/18670 0.2323 0.6395 0.5647 CDC23/ANAPC5/PSMG2/CSNK2A2/NDC80/RIOK2/FBXO5 7 GO:0006469 negative regulation of protein kinase activity 16/1036 235/18670 0.2337 0.6432 0.568 AIDA/IFNG/DUSP2/IL1B/NCK1/STK38/CBLB/PTPN22/TRIB2/CDK5RAP1/NPM1/PRKAR2B/DUSP21/HEG1/PAQR3/IPO7 16 GO:0030198 extracellular matrix organization 24/1036 368/18670 0.2343 0.6444 0.569 IL6/PTX3/ADAMTS2/MADCAM1/ITGA4/ITGA6/CAPN1/PLOD1/ITGA7/HTRA1/TNF/RECK/LRP1/SPINT1/SULF1/TIMP2/ELANE/TPSAB1/CLASP1/ITGB4/COLGALT1/ADAM15/CTSG/ITGAE 24 GO:0043583 ear development 15/1036 219/18670 0.2359 0.6485 0.5726 INSIG1/LRIG1/LHX3/PRKRA/MAPK3/GABRB2/SOD1/ROR1/NTN1/KCNQ1/SIX2/FZD2/MAF/BCR/ATG5 15 GO:0090501 RNA phosphodiester bond hydrolysis 11/1036 154/18670 0.2363 0.6491 0.5732 DROSHA/REXO2/PPP1R8/PCF11/EXOSC8/POLR3K/NUDT21/CSTF2T/RRS1/RPS21/RNASE1 11 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 9/1036 122/18670 0.2364 0.6491 0.5732 TGFBR2/FLCN/HTRA1/TGFBR3/UBA52/STK11/CITED2/UBB/ZBTB7A 9 GO:0043434 response to peptide hormone 28/1036 436/18670 0.2372 0.6511 0.5749 PARP1/STAT4/NFKB1/SOS1/IL1B/NCK1/CAT/HSD11B2/PRKCQ/PRKACB/BTG2/GCLC/FYN/CRY1/TGFBR3/ANXA1/CYC1/XBP1/QDPR/TBC1D4/PRKAR2B/PIK3CA/OTC/TIMP4/PIK3C2A/GHRHR/APRT/PIK3R1 28 GO:0006418 tRNA aminoacylation for protein translation 4/1036 45/18670 0.2385 0.6517 0.5755 IARS2/PPA1/EEF1E1/AIMP1 4 GO:0032456 endocytic recycling 4/1036 45/18670 0.2385 0.6517 0.5755 EHD2/ARL4C/VPS51/EHD3 4 GO:0048701 embryonic cranial skeleton morphogenesis 4/1036 45/18670 0.2385 0.6517 0.5755 TGFBR2/GNAS/EIF4A3/SIX2 4 GO:1902743 regulation of lamellipodium organization 4/1036 45/18670 0.2385 0.6517 0.5755 AUTS2/WAS/ARHGEF7/HDAC4 4 GO:0033013 tetrapyrrole metabolic process 5/1036 60/18670 0.2389 0.6517 0.5755 SUCLA2/MTR/RSAD1/LMBRD1/TCN2 5 GO:0045576 mast cell activation 5/1036 60/18670 0.2389 0.6517 0.5755 RHOH/CHGA/RASGRP1/SPHK2/PLA2G3 5 GO:0006650 glycerophospholipid metabolic process 21/1036 319/18670 0.2391 0.6517 0.5755 DDHD2/CHRM5/CETP/CPNE6/PNPLA6/CSNK2A2/STARD7/CPNE3/PIK3CA/GPD1L/DGKZ/PON1/AGPAT2/PIK3C2A/PRDX6/AGK/ACSL3/GDPD3/PLA2G3/PGAP1/PIK3R1 21 GO:0045639 positive regulation of myeloid cell differentiation 7/1036 91/18670 0.2406 0.6517 0.5755 IFNG/GNAS/IL12B/TNF/IL23A/LIF/HAX1 7 GO:0051899 membrane depolarization 7/1036 91/18670 0.2406 0.6517 0.5755 PARP1/GCLC/NTSR1/SCN10A/GPD1L/CACNB4/RANGRF 7 GO:0060606 tube closure 7/1036 91/18670 0.2406 0.6517 0.5755 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0060249 anatomical structure homeostasis 28/1036 437/18670 0.2409 0.6517 0.5755 CD38/PCNA/PARP1/MYC/NELL2/IL6/CCT7/LYZ/LIPA/PRKCQ/GNAS/P2RX1/CCT2/MUC2/ATR/CALB2/MAPK3/TNKS/HNRNPA2B1/AKR1B1/STK11/ATP2B2/FH/SOD1/ATRX/RPA1/TERF1/RCN3 28 GO:0048659 smooth muscle cell proliferation 12/1036 171/18670 0.2414 0.6517 0.5755 CCL5/IL6/IFNG/TGFBR2/LDLRAP1/IL12B/TNF/ELANE/HDAC4/AKR1B1/ABCC4/IL15 12 GO:0000097 sulfur amino acid biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 MTR/CBS 2 GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 2/1036 17/18670 0.2427 0.6517 0.5755 TGFBR2/ACVR1 2 GO:0006586 indolalkylamine metabolic process 2/1036 17/18670 0.2427 0.6517 0.5755 KMO/KYNU 2 GO:0006744 ubiquinone biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 PDSS1/COQ9 2 GO:0006750 glutathione biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 OPLAH/GCLC 2 GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 2/1036 17/18670 0.2427 0.6517 0.5755 FOLR3/CD9 2 GO:0008340 determination of adult lifespan 2/1036 17/18670 0.2427 0.6517 0.5755 MSH2/GHRHR 2 GO:0009070 serine family amino acid biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 SEPHS1/CBS 2 GO:0009129 pyrimidine nucleoside monophosphate metabolic process 2/1036 17/18670 0.2427 0.6517 0.5755 CMPK1/UCKL1 2 GO:0010744 positive regulation of macrophage derived foam cell differentiation 2/1036 17/18670 0.2427 0.6517 0.5755 NFKB1/PRKCH 2 GO:0014733 regulation of skeletal muscle adaptation 2/1036 17/18670 0.2427 0.6517 0.5755 ATP2A2/TNNI1 2 GO:0015732 prostaglandin transport 2/1036 17/18670 0.2427 0.6517 0.5755 IL1B/ABCC4 2 GO:0016246 RNA interference 2/1036 17/18670 0.2427 0.6517 0.5755 DROSHA/PRKRA 2 GO:0017085 response to insecticide 2/1036 17/18670 0.2427 0.6517 0.5755 UBA52/DAXX 2 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway 2/1036 17/18670 0.2427 0.6517 0.5755 PARP1/RWDD1 2 GO:0035518 histone H2A monoubiquitination 2/1036 17/18670 0.2427 0.6517 0.5755 SKP1/TRIM37 2 GO:0035988 chondrocyte proliferation 2/1036 17/18670 0.2427 0.6517 0.5755 BMPR1B/SIX2 2 GO:0042268 regulation of cytolysis 2/1036 17/18670 0.2427 0.6517 0.5755 PGLYRP4/LBP 2 GO:0042753 positive regulation of circadian rhythm 2/1036 17/18670 0.2427 0.6517 0.5755 RORA/GHRHR 2 GO:0045072 regulation of interferon-gamma biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 IL12B/TLR3 2 GO:0045187 regulation of circadian sleep/wake cycle, sleep 2/1036 17/18670 0.2427 0.6517 0.5755 GHRHR/NMU 2 GO:0045721 negative regulation of gluconeogenesis 2/1036 17/18670 0.2427 0.6517 0.5755 CRY1/CLK2 2 GO:0048521 negative regulation of behavior 2/1036 17/18670 0.2427 0.6517 0.5755 TRH/NMU 2 GO:0050665 hydrogen peroxide biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 FYN/SOD1 2 GO:0051284 positive regulation of sequestering of calcium ion 2/1036 17/18670 0.2427 0.6517 0.5755 CLIC2/NTSR1 2 GO:0051818 disruption of cells of other organism involved in symbiotic interaction 2/1036 17/18670 0.2427 0.6517 0.5755 ELANE/CTSG 2 GO:0071360 cellular response to exogenous dsRNA 2/1036 17/18670 0.2427 0.6517 0.5755 TLR3/PQBP1 2 GO:1900363 regulation of mRNA polyadenylation 2/1036 17/18670 0.2427 0.6517 0.5755 CTR9/NUDT21 2 GO:1901663 quinone biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 PDSS1/COQ9 2 GO:1902931 negative regulation of alcohol biosynthetic process 2/1036 17/18670 0.2427 0.6517 0.5755 NFKB1/SOD1 2 GO:1903975 regulation of glial cell migration 2/1036 17/18670 0.2427 0.6517 0.5755 LRP1/GPR183 2 GO:0007548 sex differentiation 18/1036 270/18670 0.2434 0.6522 0.576 ARID5B/NUP107/PTX3/BMPR1B/MSH2/TLR3/CBX2/RARA/TSPY1/CDKL2/CITED2/AKR1C3/AMHR2/SRY/UBB/SOD1/ATRX/ADAM15 18 GO:0045766 positive regulation of angiogenesis 14/1036 204/18670 0.2434 0.6522 0.576 IL1A/CCR3/TGFBR2/IL1B/PPP1R16B/RRAS/HSPB6/CXCR4/ANXA1/TLR3/XBP1/PIK3C2A/CCL11/FGF18 14 GO:0031669 cellular response to nutrient levels 16/1036 237/18670 0.2439 0.6522 0.576 ATG14/SESN1/FYN/ATF3/DNM1L/XBP1/USF2/MAPK3/TNKS/AKR1C3/IL15/PMAIP1/SOD1/TRIM24/SLC38A2/ATG5 16 GO:0043405 regulation of MAP kinase activity 22/1036 337/18670 0.2447 0.6522 0.576 AIDA/DUSP2/IL1B/STK38/MAGED1/TNF/PTPN22/CXCR4/TRIB2/RASGRP1/MAP4K5/MAPK3/UBA52/ELANE/MAP4K2/DUSP21/TLR6/DAXX/UBB/SOD1/PAQR3/FGF18 22 GO:0051783 regulation of nuclear division 13/1036 188/18670 0.2455 0.6522 0.576 IL1A/IL1B/CDC23/ANAPC5/PSMG2/PHB2/NDC80/LIF/TNKS/RIOK2/FBXO5/PKMYT1/ATRX 13 GO:0000422 autophagy of mitochondrion 6/1036 76/18670 0.2456 0.6522 0.576 OPTN/ATG14/CSNK2A2/DNM1L/HAX1/ATG5 6 GO:0046902 regulation of mitochondrial membrane permeability 6/1036 76/18670 0.2456 0.6522 0.576 MOAP1/SLC25A5/GZMB/YWHAQ/PMAIP1/SLC35F6 6 GO:0061726 mitochondrion disassembly 6/1036 76/18670 0.2456 0.6522 0.576 OPTN/ATG14/CSNK2A2/DNM1L/HAX1/ATG5 6 GO:1901264 carbohydrate derivative transport 6/1036 76/18670 0.2456 0.6522 0.576 SLC35D1/SLC25A5/SLC35A5/SLC35A1/LBP/ATG5 6 GO:0002888 positive regulation of myeloid leukocyte mediated immunity 3/1036 31/18670 0.2458 0.6522 0.576 DDX1/DDX21/SPHK2 3 GO:0007143 female meiotic nuclear division 3/1036 31/18670 0.2458 0.6522 0.576 CDC25B/FBXO5/UBB 3 GO:0007202 activation of phospholipase C activity 3/1036 31/18670 0.2458 0.6522 0.576 TXK/ITK/AVPR1B 3 GO:0010165 response to X-ray 3/1036 31/18670 0.2458 0.6522 0.576 ANXA1/MSH2/XRCC2 3 GO:0010458 exit from mitosis 3/1036 31/18670 0.2458 0.6522 0.576 CDC23/PHB2/CLASP1 3 GO:0010543 regulation of platelet activation 3/1036 31/18670 0.2458 0.6522 0.576 ABAT/PRKCQ/CD9 3 GO:0034694 response to prostaglandin 3/1036 31/18670 0.2458 0.6522 0.576 TGFBR3/PTGER4/AKR1C3 3 GO:0043457 regulation of cellular respiration 3/1036 31/18670 0.2458 0.6522 0.576 IFNG/FLCN/PIK3CA 3 GO:0050482 arachidonic acid secretion 3/1036 31/18670 0.2458 0.6522 0.576 NTSR1/ANXA1/PLA2G3 3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 3/1036 31/18670 0.2458 0.6522 0.576 SLC35D1/CHST12/CHPF2 3 GO:0050685 positive regulation of mRNA processing 3/1036 31/18670 0.2458 0.6522 0.576 TRA2B/NUDT21/PRDX6 3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 3/1036 31/18670 0.2458 0.6522 0.576 GPR18/LPAR6/P2RY10 3 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 3/1036 31/18670 0.2458 0.6522 0.576 RPS7/UBB/RPL11 3 GO:1903319 positive regulation of protein maturation 3/1036 31/18670 0.2458 0.6522 0.576 IL1B/PLGRKT/F12 3 GO:1903963 arachidonate transport 3/1036 31/18670 0.2458 0.6522 0.576 NTSR1/ANXA1/PLA2G3 3 GO:0051924 regulation of calcium ion transport 17/1036 254/18670 0.2463 0.6531 0.5767 CXCL11/CCL5/P2RX5/CLIC2/P2RX1/FYN/NTSR1/PDE4B/CXCR4/BEST1/ATP1B1/SPHK2/JPH3/CACNB4/TSPAN13/EHD3/ATG5 17 GO:0007568 aging 21/1036 321/18670 0.248 0.6573 0.5804 ABAT/TGFBR2/CTSC/DLD/CAT/KMO/GCLC/RWDD1/MSH2/LRP1/EEF1E1/ATR/NPM1/MAPK3/TIMP2/KYNU/CCL11/FBXO5/GHRHR/IL15/SOD1 21 GO:0043062 extracellular structure organization 27/1036 422/18670 0.2482 0.6575 0.5806 IL6/PTX3/ADAMTS2/CETP/MADCAM1/ITGA4/ITGA6/CAPN1/PRKACB/PLOD1/ITGA7/HTRA1/TNF/RECK/LRP1/SPINT1/SULF1/TIMP2/ELANE/TPSAB1/CLASP1/ITGB4/COLGALT1/ACSL3/ADAM15/CTSG/ITGAE 27 GO:0006672 ceramide metabolic process 7/1036 92/18670 0.2491 0.6586 0.5816 ST3GAL5/P2RX1/TNF/CERS6/SPHK2/AGK/CERK 7 GO:0045833 negative regulation of lipid metabolic process 7/1036 92/18670 0.2491 0.6586 0.5816 NFKB1/IL1B/INSIG1/CRTC3/TNF/AKR1C3/SOD1 7 GO:0051048 negative regulation of secretion 16/1036 238/18670 0.2491 0.6586 0.5816 ABAT/IL1B/CHGA/CRY1/ERBB3/TNF/PTPN22/ANXA1/RSAD2/TRH/LIF/PTGER4/CSN2/TLR6/NMU/BCR 16 GO:0048645 animal organ formation 5/1036 61/18670 0.2494 0.6586 0.5816 TGFBR2/SMARCD3/SULF1/MAPK3/CITED2 5 GO:0042737 drug catabolic process 10/1036 140/18670 0.2502 0.6586 0.5816 OXCT1/CAT/HP/NNT/QDPR/CYP2C9/ALDH3B1/PRDX6/XPNPEP1/ACAT1 10 GO:0060078 regulation of postsynaptic membrane potential 10/1036 140/18670 0.2502 0.6586 0.5816 ABAT/P2RX5/EIF4A3/P2RX1/NTSR1/CHRNA2/GLRA1/GABRB2/P2RX6/GRIN2D 10 GO:1903364 positive regulation of cellular protein catabolic process 10/1036 140/18670 0.2502 0.6586 0.5816 RCHY1/DACT1/CTSC/PSMC2/GCLC/RBX1/TRIB2/LRP1/EDEM1/PSMD10 10 GO:0009062 fatty acid catabolic process 8/1036 108/18670 0.2506 0.6586 0.5816 ABCD3/ACADM/LIPE/ETFA/SCP2/CYP4A11/ACAT1/CYP4F12 8 GO:0002715 regulation of natural killer cell mediated immunity 4/1036 46/18670 0.2507 0.6586 0.5816 CD96/SH2D1A/IL12B/RASGRP1 4 GO:0005978 glycogen biosynthetic process 4/1036 46/18670 0.2507 0.6586 0.5816 DYRK2/PASK/UGP2/PHKG1 4 GO:0006221 pyrimidine nucleotide biosynthetic process 4/1036 46/18670 0.2507 0.6586 0.5816 CMPK1/PRPS1/UCKL1/AGPAT2 4 GO:0009250 glucan biosynthetic process 4/1036 46/18670 0.2507 0.6586 0.5816 DYRK2/PASK/UGP2/PHKG1 4 GO:0043631 RNA polyadenylation 4/1036 46/18670 0.2507 0.6586 0.5816 CTR9/PCF11/NUDT21/PABPC1 4 GO:0048512 circadian behavior 4/1036 46/18670 0.2507 0.6586 0.5816 AHCY/GHRHR/NMU/NCOR1 4 GO:0071354 cellular response to interleukin-6 4/1036 46/18670 0.2507 0.6586 0.5816 NFKB1/IL6/CTR9/SPI1 4 GO:0071675 regulation of mononuclear cell migration 4/1036 46/18670 0.2507 0.6586 0.5816 CCL5/TNF/MAPK3/SLAMF8 4 GO:1990928 response to amino acid starvation 4/1036 46/18670 0.2507 0.6586 0.5816 SESN1/ATF3/MAPK3/SLC38A2 4 GO:0051209 release of sequestered calcium ion into cytosol 9/1036 124/18670 0.2508 0.6586 0.5816 CXCL11/CLIC2/NTSR1/TRPM2/LCK/PLCB3/JPH3/MCOLN1/ATG5 9 GO:0032481 positive regulation of type I interferon production 6/1036 77/18670 0.255 0.6693 0.591 NFKB1/PTPN22/POLR3K/TLR3/POLR3C/PQBP1 6 GO:0000280 nuclear division 26/1036 407/18670 0.2557 0.6708 0.5923 MYBL1/IL1A/KIF2A/IL1B/AURKC/CDC23/CDC25B/ANAPC5/USP16/ZWINT/PSMG2/HIRA/PHB2/NDC80/LIF/TNKS/RIOK2/CLASP1/FBXO5/RRS1/PKMYT1/UBB/ATRX/PRC1/TERF1/SMC2 26 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 17/1036 256/18670 0.2563 0.6721 0.5935 CCL5/IL6/IFNG/IL12B/CBLB/ACVR1/FYN/ERBB3/TNF/IL23A/LIF/IL15/HAX1/CD3E/ADNP/IL3/NCAPG2 17 GO:0045444 fat cell differentiation 15/1036 223/18670 0.2573 0.6738 0.595 ARID5B/IL6/RORA/INSIG1/ITGA6/ZFP36/TNF/TRIB2/MEX3C/XBP1/ASXL2/ZBTB16/ATAT1/ZNF516/ZBTB7A 15 GO:0006903 vesicle targeting 7/1036 93/18670 0.2576 0.6738 0.595 CTSC/SCFD1/MAP4K2/CLASP1/GOSR1/SEC24A/TMED2 7 GO:0033273 response to vitamin 7/1036 93/18670 0.2576 0.6738 0.595 CAT/NNT/RARA/KYNU/OTC/IL15/TRIM24 7 GO:0036473 cell death in response to oxidative stress 7/1036 93/18670 0.2576 0.6738 0.595 PARP1/SFPQ/FYN/LANCL1/PDE8A/TLR6/SOD1 7 GO:1901655 cellular response to ketone 7/1036 93/18670 0.2576 0.6738 0.595 RWDD1/FDX1/SPHK2/AKR1B1/PTGER4/AKR1C3/ADAM15 7 GO:0001676 long-chain fatty acid metabolic process 8/1036 109/18670 0.2584 0.6757 0.5966 LIPE/MAPK3/SCP2/CYP2C9/AKR1C3/ACSL3/CYP4A11/CYP4F12 8 GO:0006220 pyrimidine nucleotide metabolic process 5/1036 62/18670 0.2601 0.6762 0.5971 DCK/CMPK1/PRPS1/UCKL1/AGPAT2 5 GO:0010676 positive regulation of cellular carbohydrate metabolic process 5/1036 62/18670 0.2601 0.6762 0.5971 DYRK2/DUSP12/CD244/NTSR1/PMAIP1 5 GO:0032922 circadian regulation of gene expression 5/1036 62/18670 0.2601 0.6762 0.5971 RORA/MAGED1/CRY1/PPP1CC/GFPT1 5 GO:0001569 branching involved in blood vessel morphogenesis 3/1036 32/18670 0.261 0.6762 0.5971 TGFBR2/ACVR1/RBM15 3 GO:0002323 natural killer cell activation involved in immune response 3/1036 32/18670 0.261 0.6762 0.5971 IL12B/CD244/PGLYRP4 3 GO:0039694 viral RNA genome replication 3/1036 32/18670 0.261 0.6762 0.5971 PCBP1/APOBEC3G/ATG5 3 GO:0045589 regulation of regulatory T cell differentiation 3/1036 32/18670 0.261 0.6762 0.5971 DROSHA/IFNG/LILRB4 3 GO:0045907 positive regulation of vasoconstriction 3/1036 32/18670 0.261 0.6762 0.5971 CD38/HRH2/AVPR1B 3 GO:0048841 regulation of axon extension involved in axon guidance 3/1036 32/18670 0.261 0.6762 0.5971 SEMA4G/SEMA3G/DSCAM 3 GO:0055094 response to lipoprotein particle 3/1036 32/18670 0.261 0.6762 0.5971 NPC1/CD9/TLR6 3 GO:0060674 placenta blood vessel development 3/1036 32/18670 0.261 0.6762 0.5971 SPINT1/RBM15/TMED2 3 GO:0061384 heart trabecula morphogenesis 3/1036 32/18670 0.261 0.6762 0.5971 SOS1/TGFBR3/HEG1 3 GO:0086019 cell-cell signaling involved in cardiac conduction 3/1036 32/18670 0.261 0.6762 0.5971 SCN10A/RANGRF/KCNQ1 3 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 3/1036 32/18670 0.261 0.6762 0.5971 NCK1/XBP1/PMAIP1 3 GO:0016482 cytosolic transport 11/1036 158/18670 0.262 0.6762 0.5971 SRSF10/STX10/MAP2/STX8/EMP2/CCDC91/RAB9A/MAPK3/VPS51/EHD3/GOSR1 11 GO:0007622 rhythmic behavior 4/1036 47/18670 0.2631 0.6762 0.5971 AHCY/GHRHR/NMU/NCOR1 4 GO:0043303 mast cell degranulation 4/1036 47/18670 0.2631 0.6762 0.5971 CHGA/RASGRP1/SPHK2/PLA2G3 4 GO:0045646 regulation of erythrocyte differentiation 4/1036 47/18670 0.2631 0.6762 0.5971 HSPA9/ZFP36/SPI1/NCAPG2 4 GO:0047496 vesicle transport along microtubule 4/1036 47/18670 0.2631 0.6762 0.5971 KIFAP3/MAP2/RASGRP1/FYCO1 4 GO:0051181 cofactor transport 4/1036 47/18670 0.2631 0.6762 0.5971 FOLR3/SLC25A32/LMBRD1/TCN2 4 GO:0120163 negative regulation of cold-induced thermogenesis 4/1036 47/18670 0.2631 0.6762 0.5971 FLCN/PLCL1/STK11/IL15 4 GO:1901659 glycosyl compound biosynthetic process 4/1036 47/18670 0.2631 0.6762 0.5971 DCK/CMPK1/UCKL1/APRT 4 GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/1036 47/18670 0.2631 0.6762 0.5971 IL1A/IL1B/FYN/TNF 4 GO:0042594 response to starvation 13/1036 191/18670 0.2632 0.6762 0.5971 ATG14/OXCT1/SESN1/ZFP36/ATF3/ADSL/XBP1/MAPK3/AKR1C3/PMAIP1/SLC38A2/ACAT1/ATG5 13 GO:0006743 ubiquinone metabolic process 2/1036 18/18670 0.2637 0.6762 0.5971 PDSS1/COQ9 2 GO:0007597 blood coagulation, intrinsic pathway 2/1036 18/18670 0.2637 0.6762 0.5971 C1QBP/F12 2 GO:0009048 dosage compensation by inactivation of X chromosome 2/1036 18/18670 0.2637 0.6762 0.5971 RBM15/RBM15B 2 GO:0009084 glutamine family amino acid biosynthetic process 2/1036 18/18670 0.2637 0.6762 0.5971 OTC/SLC1A3 2 GO:0010832 negative regulation of myotube differentiation 2/1036 18/18670 0.2637 0.6762 0.5971 XBP1/HDAC4 2 GO:0016446 somatic hypermutation of immunoglobulin genes 2/1036 18/18670 0.2637 0.6762 0.5971 MSH2/POLQ 2 GO:0031293 membrane protein intracellular domain proteolysis 2/1036 18/18670 0.2637 0.6762 0.5971 NFKB1/APH1B 2 GO:0034199 activation of protein kinase A activity 2/1036 18/18670 0.2637 0.6762 0.5971 PRKACB/PRKAR2B 2 GO:0042095 interferon-gamma biosynthetic process 2/1036 18/18670 0.2637 0.6762 0.5971 IL12B/TLR3 2 GO:0043011 myeloid dendritic cell differentiation 2/1036 18/18670 0.2637 0.6762 0.5971 TGFBR2/SPI1 2 GO:0048268 clathrin coat assembly 2/1036 18/18670 0.2637 0.6762 0.5971 PIK3C2A/AP2B1 2 GO:0070233 negative regulation of T cell apoptotic process 2/1036 18/18670 0.2637 0.6762 0.5971 CCL5/PRKCQ 2 GO:0072077 renal vesicle morphogenesis 2/1036 18/18670 0.2637 0.6762 0.5971 LIF/SIX2 2 GO:1903019 negative regulation of glycoprotein metabolic process 2/1036 18/18670 0.2637 0.6762 0.5971 ITM2A/PTX3 2 GO:1904262 negative regulation of TORC1 signaling 2/1036 18/18670 0.2637 0.6762 0.5971 SESN1/STK11 2 GO:2000757 negative regulation of peptidyl-lysine acetylation 2/1036 18/18670 0.2637 0.6762 0.5971 SPI1/ATG5 2 GO:0000271 polysaccharide biosynthetic process 6/1036 78/18670 0.2645 0.6776 0.5983 DYRK2/NFKB1/PASK/UGP2/PHKG1/B3GNT2 6 GO:0006487 protein N-linked glycosylation 6/1036 78/18670 0.2645 0.6776 0.5983 ALG13/ASGR2/ASGR1/MGAT2/UBE2J1/GFPT1 6 GO:0018107 peptidyl-threonine phosphorylation 9/1036 126/18670 0.2655 0.6796 0.6001 DYRK2/TGFBR2/ACVR1/CSNK2A2/TNKS/VRK1/DYRK3/DYRK1A/CDC7 9 GO:0051283 negative regulation of sequestering of calcium ion 9/1036 126/18670 0.2655 0.6796 0.6001 CXCL11/CLIC2/NTSR1/TRPM2/LCK/PLCB3/JPH3/MCOLN1/ATG5 9 GO:1901215 negative regulation of neuron death 14/1036 208/18670 0.266 0.6804 0.6009 RASA1/BTG2/GCLC/FYN/CHGA/ERBB3/MSH2/LRP1/PIK3CA/GABRB2/SOD1/AP2B1/ADNP/XRCC2 14 GO:0006029 proteoglycan metabolic process 7/1036 94/18670 0.2662 0.6804 0.6009 SLC35D1/CHST12/BMPR1B/CHPF2/SGSH/SULF1/FAM20B 7 GO:0006939 smooth muscle contraction 8/1036 110/18670 0.2664 0.6804 0.6009 CD38/ABAT/P2RX1/SULF1/CHRM2/PIK3C2A/SOD1/NMU 8 GO:0033559 unsaturated fatty acid metabolic process 8/1036 110/18670 0.2664 0.6804 0.6009 IL1B/ANXA1/MAPK3/SCP2/CYP2C9/AKR1C3/CYP4A11/CYP4F12 8 GO:0019216 regulation of lipid metabolic process 26/1036 410/18670 0.2678 0.6837 0.6037 NFKB1/IFNG/ATG14/IL1B/IDI1/CHRM5/RORA/INSIG1/CRTC3/LDLRAP1/TNF/ACADM/ANXA1/SMARCD3/BCL11B/NFYB/CCKBR/SPHK2/DGKZ/AKR1C3/SC5D/SOD1/ACSL3/NCOR1/PIK3R1/CYP4A11 26 GO:0043270 positive regulation of ion transport 18/1036 275/18670 0.2679 0.6837 0.6037 CXCL11/ABAT/CCL5/ABCB1/IFNG/IL1B/P2RX5/KMO/P2RX1/NTSR1/ATP8A1/GPD1L/TRH/ATP1B1/SPHK2/EHD3/KCNQ1/CYP4A11 18 GO:0001649 osteoblast differentiation 15/1036 225/18670 0.2683 0.6844 0.6044 IL6/FBL/CAT/GNAS/PSMC2/ACVR1/TNF/HIRA/BMPR1B/DDX21/HSPE1/RRAS2/HDAC4/PDLIM7/FBXO5 15 GO:0006665 sphingolipid metabolic process 11/1036 159/18670 0.2686 0.6849 0.6048 ST3GAL5/CREM/ESYT1/P2RX1/TNF/CERS6/ARSA/SPHK2/ALDH3B1/AGK/CERK 11 GO:0043112 receptor metabolic process 13/1036 192/18670 0.2692 0.6857 0.6055 OPTN/IFNG/TRAT1/CAPN1/LDLRAP1/GPRASP1/TNF/FNTA/LRP1/CD9/EHD3/AP2B1/SEC24A 13 GO:1901136 carbohydrate derivative catabolic process 13/1036 192/18670 0.2692 0.6857 0.6055 HINT1/DERA/ENPP4/PDE4B/SGSH/EDEM1/AHCY/GPD1L/PDE8A/APOBEC3G/NUDT9/PGLYRP4/ACAT1 13 GO:0042982 amyloid precursor protein metabolic process 5/1036 63/18670 0.2708 0.6891 0.6085 ITM2A/IFNG/LDLRAP1/TNF/DYRK1A 5 GO:0090181 regulation of cholesterol metabolic process 5/1036 63/18670 0.2708 0.6891 0.6085 IDI1/LDLRAP1/NFYB/SC5D/SOD1 5 GO:0044344 cellular response to fibroblast growth factor stimulus 10/1036 143/18670 0.271 0.6893 0.6086 CCL5/CEP57/HNRNPF/ZFP36/GCLC/TIA1/SULF1/MAPK3/SETX/FGF18 10 GO:0023061 signal release 29/1036 462/18670 0.2715 0.6903 0.6096 CD38/ABAT/CCL5/IL6/IFNG/IL1B/OXCT1/PASK/UBE2Q1/GNAS/ATP2A2/KMO/SLC25A5/P2RX1/DYNLL1/CHGA/CRY1/TNF/SV2A/ANXA1/LRP1/DNM1L/TRH/LIF/AIMP1/CHRM2/GHRHR/NMU/GAD2 29 GO:0050796 regulation of insulin secretion 12/1036 176/18670 0.2723 0.6916 0.6107 CD38/ABAT/CCL5/IFNG/IL1B/OXCT1/SLC25A5/DYNLL1/CHGA/TNF/LRP1/TRH 12 GO:0051897 positive regulation of protein kinase B signaling 12/1036 176/18670 0.2723 0.6916 0.6107 TRAT1/C1QBP/ICOS/FYN/ERBB3/TNF/LCK/PIK3CA/AKR1C3/HAX1/FGF18/PIK3R1 12 GO:0003151 outflow tract morphogenesis 6/1036 79/18670 0.274 0.6929 0.6118 TGFBR2/TGFBR3/PARVA/RARA/CITED2/FZD2 6 GO:0021675 nerve development 6/1036 79/18670 0.274 0.6929 0.6118 ITGA4/ERBB3/LRIG1/SULF1/GABRB2/SLC1A3 6 GO:0031110 regulation of microtubule polymerization or depolymerization 6/1036 79/18670 0.274 0.6929 0.6118 CKAP2/MAP2/RANGRF/CLASP1/DYRK1A/TERF1 6 GO:0098661 inorganic anion transmembrane transport 8/1036 111/18670 0.2744 0.6929 0.6118 CLIC2/SLC12A5/BEST1/GLRA1/GABRB2/GABRP/SLC20A1/SLC1A3 8 GO:1904019 epithelial cell apoptotic process 8/1036 111/18670 0.2744 0.6929 0.6118 IL6/TGFBR2/ITGA4/ZFP36/TNF/TIA1/PIAS4/AKR1C3 8 GO:0097711 ciliary basal body-plasma membrane docking 7/1036 95/18670 0.2749 0.6929 0.6118 CEP57/DYNLL1/PRKAR2B/HAUS2/PCM1/CEP76/CLASP1 7 GO:0046677 response to antibiotic 21/1036 327/18670 0.2752 0.6929 0.6118 PCNA/ABAT/IL6/OXCT1/CAT/PSMD14/HP/FYN/TRPM2/ANXA1/FDX1/RARA/GLRA1/TRH/PDE8A/SPI1/DAXX/SETX/SOD1/CBX8/SLC1A3 21 GO:0046661 male sex differentiation 11/1036 160/18670 0.2753 0.6929 0.6118 ARID5B/MSH2/TLR3/RARA/CITED2/AKR1C3/AMHR2/SRY/UBB/ATRX/ADAM15 11 GO:0002279 mast cell activation involved in immune response 4/1036 48/18670 0.2756 0.6929 0.6118 CHGA/RASGRP1/SPHK2/PLA2G3 4 GO:0030850 prostate gland development 4/1036 48/18670 0.2756 0.6929 0.6118 ANXA1/SULF1/RARA/STK11 4 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 4/1036 48/18670 0.2756 0.6929 0.6118 CBLB/ARHGEF7/EPS15L1/RNF115 4 GO:0043039 tRNA aminoacylation 4/1036 48/18670 0.2756 0.6929 0.6118 IARS2/PPA1/EEF1E1/AIMP1 4 GO:0045933 positive regulation of muscle contraction 4/1036 48/18670 0.2756 0.6929 0.6118 ABAT/CHGA/KCNQ1/NMU 4 GO:0060324 face development 4/1036 48/18670 0.2756 0.6929 0.6118 ARID5B/RRAS/RARA/MAPK3 4 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 4/1036 48/18670 0.2756 0.6929 0.6118 RPS7/CSNK2A2/WAC/RPL11 4 GO:0001914 regulation of T cell mediated cytotoxicity 3/1036 33/18670 0.2763 0.6929 0.6118 IL12B/CD1A/IL23A 3 GO:0002717 positive regulation of natural killer cell mediated immunity 3/1036 33/18670 0.2763 0.6929 0.6118 SH2D1A/IL12B/RASGRP1 3 GO:0010591 regulation of lamellipodium assembly 3/1036 33/18670 0.2763 0.6929 0.6118 AUTS2/WAS/HDAC4 3 GO:0030851 granulocyte differentiation 3/1036 33/18670 0.2763 0.6929 0.6118 RARA/SPI1/HAX1 3 GO:0033028 myeloid cell apoptotic process 3/1036 33/18670 0.2763 0.6929 0.6118 CCL5/IL6/ANXA1 3 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 3/1036 33/18670 0.2763 0.6929 0.6118 OXCT1/DYNLL1/LRP1 3 GO:0036314 response to sterol 3/1036 33/18670 0.2763 0.6929 0.6118 TGFBR2/RORA/INSIG1 3 GO:0045191 regulation of isotype switching 3/1036 33/18670 0.2763 0.6929 0.6118 TNFSF13/MSH2/TBX21 3 GO:0060603 mammary gland duct morphogenesis 3/1036 33/18670 0.2763 0.6929 0.6118 PHB2/CCL11/NTN1 3 GO:0061036 positive regulation of cartilage development 3/1036 33/18670 0.2763 0.6929 0.6118 BMPR1B/ZBTB16/FGF18 3 GO:0070536 protein K63-linked deubiquitination 3/1036 33/18670 0.2763 0.6929 0.6118 USP25/PSMD14/USP16 3 GO:1901797 negative regulation of signal transduction by p53 class mediator 3/1036 33/18670 0.2763 0.6929 0.6118 DYRK3/PSMD10/DYRK1A 3 GO:0009612 response to mechanical stimulus 14/1036 210/18670 0.2776 0.6958 0.6144 NFKB1/TGFBR2/IL1B/BTG2/GCLC/PIEZO2/FYN/CXCR4/TLR3/MAPK3/HDAC4/PTGER4/SLC38A2/SLC1A3 14 GO:0001959 regulation of cytokine-mediated signaling pathway 12/1036 177/18670 0.2786 0.6981 0.6164 CCL5/IL6/IFNG/BIRC3/TNF/TRIM44/CXCR4/TXK/PIAS4/AGPAT2/USP18/IL3 12 GO:0051282 regulation of sequestering of calcium ion 9/1036 128/18670 0.2805 0.6985 0.6168 CXCL11/CLIC2/NTSR1/TRPM2/LCK/PLCB3/JPH3/MCOLN1/ATG5 9 GO:0046503 glycerolipid catabolic process 5/1036 64/18670 0.2816 0.6985 0.6168 DDHD2/PNPLA6/LIPE/PRDX6/GDPD3 5 GO:0046579 positive regulation of Ras protein signal transduction 5/1036 64/18670 0.2816 0.6985 0.6168 AUTS2/GPR18/RASGRP1/LPAR6/P2RY10 5 GO:0050922 negative regulation of chemotaxis 5/1036 64/18670 0.2816 0.6985 0.6168 GPR18/SEMA4G/ELANE/SEMA3G/SLAMF8 5 GO:2000378 negative regulation of reactive oxygen species metabolic process 5/1036 64/18670 0.2816 0.6985 0.6168 HP/FYN/KHSRP/BCR/ATG5 5 GO:0035967 cellular response to topologically incorrect protein 11/1036 161/18670 0.282 0.6985 0.6168 OPTN/NCK1/HSPA9/DERL1/ATF3/XBP1/EDEM1/HSPA14/DAXX/PIK3R1/GFPT1 11 GO:0001822 kidney development 18/1036 278/18670 0.283 0.6985 0.6168 ARID5B/MYC/NUP107/FLCN/CAT/ODC1/MAGED1/HSPB11/PRKX/SULF1/RARA/NUP85/LIF/AKR1B1/ZBTB16/NUP160/SIX2/ACAT1 18 GO:0008585 female gonad development 7/1036 96/18670 0.2837 0.6985 0.6168 ARID5B/NUP107/PTX3/BMPR1B/AMHR2/UBB/SOD1 7 GO:0042632 cholesterol homeostasis 7/1036 96/18670 0.2837 0.6985 0.6168 CETP/RORA/INSIG1/LDLRAP1/NPC1/XBP1/SEC24A 7 GO:0043462 regulation of ATPase activity 6/1036 80/18670 0.2837 0.6985 0.6168 DNAJC9/DYNLL1/DNAJB1/OXA1L/ATP1B1/TOR1AIP1 6 GO:0048608 reproductive structure development 27/1036 431/18670 0.284 0.6985 0.6168 ARID5B/NUP107/PTX3/HTRA1/LHX3/BMPR1B/ANXA1/MSH2/SPINT1/TLR3/SULF1/RARA/TSPY1/MAPK3/LIF/RBM15/STK11/CITED2/AKR1C3/AMHR2/SRY/BPTF/UBB/SOD1/ATRX/ADAM15/TMED2 27 GO:0000028 ribosomal small subunit assembly 2/1036 19/18670 0.2847 0.6985 0.6168 RPS5/PWP2 2 GO:0001832 blastocyst growth 2/1036 19/18670 0.2847 0.6985 0.6168 CTR9/NCAPG2 2 GO:0002566 somatic diversification of immune receptors via somatic mutation 2/1036 19/18670 0.2847 0.6985 0.6168 MSH2/POLQ 2 GO:0002689 negative regulation of leukocyte chemotaxis 2/1036 19/18670 0.2847 0.6985 0.6168 GPR18/SLAMF8 2 GO:0002922 positive regulation of humoral immune response 2/1036 19/18670 0.2847 0.6985 0.6168 IL1B/TNF 2 GO:0006448 regulation of translational elongation 2/1036 19/18670 0.2847 0.6985 0.6168 EIF4A3/USP16 2 GO:0006555 methionine metabolic process 2/1036 19/18670 0.2847 0.6985 0.6168 MTR/AHCY 2 GO:0007096 regulation of exit from mitosis 2/1036 19/18670 0.2847 0.6985 0.6168 CDC23/PHB2 2 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 2/1036 19/18670 0.2847 0.6985 0.6168 CHRM5/CHRM2 2 GO:0007625 grooming behavior 2/1036 19/18670 0.2847 0.6985 0.6168 NMU/APRT 2 GO:0010523 negative regulation of calcium ion transport into cytosol 2/1036 19/18670 0.2847 0.6985 0.6168 CLIC2/NTSR1 2 GO:0010544 negative regulation of platelet activation 2/1036 19/18670 0.2847 0.6985 0.6168 ABAT/CD9 2 GO:0010888 negative regulation of lipid storage 2/1036 19/18670 0.2847 0.6985 0.6168 IL6/TNF 2 GO:0016048 detection of temperature stimulus 2/1036 19/18670 0.2847 0.6985 0.6168 NTSR1/CXCR4 2 GO:0016075 rRNA catabolic process 2/1036 19/18670 0.2847 0.6985 0.6168 DROSHA/EXOSC8 2 GO:0019184 nonribosomal peptide biosynthetic process 2/1036 19/18670 0.2847 0.6985 0.6168 OPLAH/GCLC 2 GO:0021533 cell differentiation in hindbrain 2/1036 19/18670 0.2847 0.6985 0.6168 RORA/HERC1 2 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 2/1036 19/18670 0.2847 0.6985 0.6168 IL1B/FGF18 2 GO:0032700 negative regulation of interleukin-17 production 2/1036 19/18670 0.2847 0.6985 0.6168 IFNG/IL12B 2 GO:0033189 response to vitamin A 2/1036 19/18670 0.2847 0.6985 0.6168 CAT/RARA 2 GO:0034312 diol biosynthetic process 2/1036 19/18670 0.2847 0.6985 0.6168 QDPR/SPHK2 2 GO:0034755 iron ion transmembrane transport 2/1036 19/18670 0.2847 0.6985 0.6168 IFNG/MCOLN1 2 GO:0045414 regulation of interleukin-8 biosynthetic process 2/1036 19/18670 0.2847 0.6985 0.6168 TNF/ELANE 2 GO:0046597 negative regulation of viral entry into host cell 2/1036 19/18670 0.2847 0.6985 0.6168 PTX3/FCN1 2 GO:0060004 reflex 2/1036 19/18670 0.2847 0.6985 0.6168 GLRA1/SATB1 2 GO:0060149 negative regulation of posttranscriptional gene silencing 2/1036 19/18670 0.2847 0.6985 0.6168 ELAVL1/NCOR1 2 GO:0060231 mesenchymal to epithelial transition 2/1036 19/18670 0.2847 0.6985 0.6168 LIF/SIX2 2 GO:0060967 negative regulation of gene silencing by RNA 2/1036 19/18670 0.2847 0.6985 0.6168 ELAVL1/NCOR1 2 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 2/1036 19/18670 0.2847 0.6985 0.6168 DDX1/DDX21 2 GO:0072074 kidney mesenchyme development 2/1036 19/18670 0.2847 0.6985 0.6168 MYC/SIX2 2 GO:0072087 renal vesicle development 2/1036 19/18670 0.2847 0.6985 0.6168 LIF/SIX2 2 GO:1904683 regulation of metalloendopeptidase activity 2/1036 19/18670 0.2847 0.6985 0.6168 RECK/MBP 2 GO:1905939 regulation of gonad development 2/1036 19/18670 0.2847 0.6985 0.6168 CITED2/SRY 2 GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2/1036 19/18670 0.2847 0.6985 0.6168 PRKX/LIF 2 GO:0022406 membrane docking 12/1036 178/18670 0.285 0.6989 0.6172 ATG14/ESYT1/CEP57/DYNLL1/SCFD1/STX10/STX8/PRKAR2B/HAUS2/PCM1/CEP76/CLASP1 12 GO:0007605 sensory perception of sound 10/1036 145/18670 0.2851 0.6989 0.6172 LRIG1/MBP/GABRB2/ATP2B2/OTOR/SOD1/ROR1/KCNQ1/PGAP1/SLC1A3 10 GO:0098813 nuclear chromosome segregation 17/1036 262/18670 0.2874 0.7042 0.6218 SFPQ/AURKC/CDC23/ANAPC5/ZWINT/PSMG2/HIRA/PHB2/NDC80/TNKS/RIOK2/FBXO5/RRS1/ATRX/PRC1/TERF1/SMC2 17 GO:0002448 mast cell mediated immunity 4/1036 49/18670 0.2881 0.7044 0.622 CHGA/RASGRP1/SPHK2/PLA2G3 4 GO:0043038 amino acid activation 4/1036 49/18670 0.2881 0.7044 0.622 IARS2/PPA1/EEF1E1/AIMP1 4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 4/1036 49/18670 0.2881 0.7044 0.622 RHOH/OPTN/RORA/ZMYND11 4 GO:0051445 regulation of meiotic cell cycle 4/1036 49/18670 0.2881 0.7044 0.622 CDC25B/PRKACB/LIF/FBXO5 4 GO:0097300 programmed necrotic cell death 4/1036 49/18670 0.2881 0.7044 0.622 BIRC3/TNF/DNM1L/TLR3 4 GO:0043200 response to amino acid 8/1036 113/18670 0.2906 0.7054 0.6229 PCNA/SESN1/GCLC/FYN/TNF/XBP1/GLRA1/TOMM20 8 GO:0048771 tissue remodeling 12/1036 179/18670 0.2915 0.7054 0.6229 CD38/IL1A/IL6/LIPA/CAPN1/IL12B/ANXA1/IL23A/LIF/IL15/BCR/ATG5 12 GO:0051099 positive regulation of binding 12/1036 179/18670 0.2915 0.7054 0.6229 PARP1/IFNG/DACT1/CLIC2/DERL1/PLCL1/CAPRIN2/LRP1/GMNN/RARA/PON1/RPL11 12 GO:1903034 regulation of response to wounding 12/1036 179/18670 0.2915 0.7054 0.6229 ABAT/TGFBR2/ENPP4/WFDC1/PRKCQ/F12/CXCR4/ANXA1/LRP1/XBP1/CLASP1/CD9 12 GO:0002183 cytoplasmic translational initiation 3/1036 34/18670 0.2917 0.7054 0.6229 EIF4B/NCK1/EIF5 3 GO:0003382 epithelial cell morphogenesis 3/1036 34/18670 0.2917 0.7054 0.6229 HRH2/BCL11B/HEG1 3 GO:0006536 glutamate metabolic process 3/1036 34/18670 0.2917 0.7054 0.6229 GCLC/GAD2/SLC1A3 3 GO:0007603 phototransduction, visible light 3/1036 34/18670 0.2917 0.7054 0.6229 METAP1/FNTA/METAP2 3 GO:0017004 cytochrome complex assembly 3/1036 34/18670 0.2917 0.7054 0.6229 UQCRB/FASTKD3/OXA1L 3 GO:0034205 amyloid-beta formation 3/1036 34/18670 0.2917 0.7054 0.6229 IFNG/TNF/DYRK1A 3 GO:0042533 tumor necrosis factor biosynthetic process 3/1036 34/18670 0.2917 0.7054 0.6229 IFNG/UBE2J1/LBP 3 GO:0042534 regulation of tumor necrosis factor biosynthetic process 3/1036 34/18670 0.2917 0.7054 0.6229 IFNG/UBE2J1/LBP 3 GO:0042558 pteridine-containing compound metabolic process 3/1036 34/18670 0.2917 0.7054 0.6229 SLC25A32/MTR/QDPR 3 GO:0043094 cellular metabolic compound salvage 3/1036 34/18670 0.2917 0.7054 0.6229 DCK/UCKL1/APRT 3 GO:0043276 anoikis 3/1036 34/18670 0.2917 0.7054 0.6229 DAPK2/PIK3CA/STK11 3 GO:0045066 regulatory T cell differentiation 3/1036 34/18670 0.2917 0.7054 0.6229 DROSHA/IFNG/LILRB4 3 GO:0070884 regulation of calcineurin-NFAT signaling cascade 3/1036 34/18670 0.2917 0.7054 0.6229 DYRK2/ERBB3/TNF 3 GO:0071402 cellular response to lipoprotein particle stimulus 3/1036 34/18670 0.2917 0.7054 0.6229 NPC1/CD9/TLR6 3 GO:0071868 cellular response to monoamine stimulus 3/1036 34/18670 0.2917 0.7054 0.6229 PDE4B/MAPK3/KCNQ1 3 GO:0071870 cellular response to catecholamine stimulus 3/1036 34/18670 0.2917 0.7054 0.6229 PDE4B/MAPK3/KCNQ1 3 GO:0106056 regulation of calcineurin-mediated signaling 3/1036 34/18670 0.2917 0.7054 0.6229 DYRK2/ERBB3/TNF 3 GO:0002224 toll-like receptor signaling pathway 10/1036 146/18670 0.2923 0.7054 0.6229 BIRC3/PTPN22/TLR3/RSAD2/UBA52/RFTN1/TLR6/UBB/RPS6KA3/LBP 10 GO:0055123 digestive system development 10/1036 146/18670 0.2923 0.7054 0.6229 TGFBR2/DACT1/ITGA6/TNF/HRH2/XBP1/CCKBR/OTC/ITGB4/SIX2 10 GO:2001251 negative regulation of chromosome organization 10/1036 146/18670 0.2923 0.7054 0.6229 PARP1/PSMG2/NDC80/TNKS/SPHK2/FBXO5/SPI1/ATRX/TERF1/ATG5 10 GO:0006940 regulation of smooth muscle contraction 5/1036 65/18670 0.2925 0.7054 0.6229 ABAT/P2RX1/CHRM2/SOD1/NMU 5 GO:0072678 T cell migration 5/1036 65/18670 0.2925 0.7054 0.6229 CXCL11/CCL5/ITGA4/CD99/GPR183 5 GO:0007044 cell-substrate junction assembly 7/1036 97/18670 0.2925 0.7054 0.6229 ITGA6/LRP1/ARHGEF7/ACTN1/CLASP1/ITGB4/BCR 7 GO:0014020 primary neural tube formation 7/1036 97/18670 0.2925 0.7054 0.6229 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0043255 regulation of carbohydrate biosynthetic process 7/1036 97/18670 0.2925 0.7054 0.6229 DYRK2/NFKB1/PASK/CD244/NTSR1/CRY1/CLK2 7 GO:0055092 sterol homeostasis 7/1036 97/18670 0.2925 0.7054 0.6229 CETP/RORA/INSIG1/LDLRAP1/NPC1/XBP1/SEC24A 7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 6/1036 81/18670 0.2934 0.7069 0.6242 TGFBR2/HTRA1/TGFBR3/UBA52/UBB/ZBTB7A 6 GO:0110110 positive regulation of animal organ morphogenesis 6/1036 81/18670 0.2934 0.7069 0.6242 MYC/TGFBR2/MAGED1/ACVR1/XBP1/LIF 6 GO:0050727 regulation of inflammatory response 30/1036 485/18670 0.2944 0.7091 0.6261 DROSHA/NFKB1/CCL5/IL6/IL1B/C1QBP/RORA/CTSC/WFDC1/IL12B/PSMA1/BIRC3/TNF/F12/C8B/ANXA1/TLR3/IL23A/CST7/ELANE/USP18/PTGER4/TLR6/IL15/SOD1/CD5L/SLAMF8/IL17B/BCR/LBP 30 GO:0045931 positive regulation of mitotic cell cycle 11/1036 163/18670 0.2955 0.7113 0.6281 IL1A/IL1B/CDC25B/ANAPC5/ANKRD17/ANXA1/PHB2/SMARCD3/NDC80/FBXO5/CDC7 11 GO:0031346 positive regulation of cell projection organization 24/1036 383/18670 0.2979 0.7167 0.6329 AUTS2/NCK1/ATMIN/ITGA6/DYNLL1/CPNE6/FYN/CAPRIN2/CXCR4/PLXNB2/LRP1/DNM1L/ARHGEF7/TMEM106B/HDAC4/STK11/DBN1/CAPRIN1/DSCAM/SETX/ZMYND10/NTN1/ADNP/FEZ1 24 GO:0010976 positive regulation of neuron projection development 18/1036 281/18670 0.2984 0.7176 0.6337 NCK1/ITGA6/CPNE6/FYN/CAPRIN2/CXCR4/PLXNB2/LRP1/DNM1L/TMEM106B/STK11/DBN1/CAPRIN1/DSCAM/SETX/NTN1/ADNP/FEZ1 18 GO:0070661 leukocyte proliferation 19/1036 298/18670 0.2987 0.7176 0.6337 CD38/SOS1/CCL5/IL6/TGFBR2/IL1B/MALT1/NCK1/PRKCQ/IL12B/FYN/PTPN22/ANXA1/IL23A/GPR183/IL15/CD3E/SATB1/CLC 19 GO:0051961 negative regulation of nervous system development 20/1036 315/18670 0.2987 0.7176 0.6337 CD38/IL6/IL1B/CTSC/PRKACB/DAAM2/ARHGAP4/TNF/MAP2/LRP1/SEMA4G/PCM1/TLX3/SEMA3G/CCL11/HMG20A/NTN1/PAQR3/EFNB3/CRMP1 20 GO:0030218 erythrocyte differentiation 8/1036 114/18670 0.2988 0.7176 0.6337 HSPA9/ZFP36/TGFBR3/DYRK3/SPI1/RHAG/NCAPG2/ZBTB7A 8 GO:0001961 positive regulation of cytokine-mediated signaling pathway 4/1036 50/18670 0.3008 0.7193 0.6352 TRIM44/CXCR4/TXK/AGPAT2 4 GO:0010171 body morphogenesis 4/1036 50/18670 0.3008 0.7193 0.6352 ARID5B/GNAS/RRAS/CLASP1 4 GO:0010718 positive regulation of epithelial to mesenchymal transition 4/1036 50/18670 0.3008 0.7193 0.6352 IL6/TGFBR2/IL1B/ACVR1 4 GO:0042398 cellular modified amino acid biosynthetic process 4/1036 50/18670 0.3008 0.7193 0.6352 OPLAH/PLOD1/GCLC/ACADM 4 GO:0045104 intermediate filament cytoskeleton organization 4/1036 50/18670 0.3008 0.7193 0.6352 SYNM/KRT9/PRPH/SOD1 4 GO:0045540 regulation of cholesterol biosynthetic process 4/1036 50/18670 0.3008 0.7193 0.6352 IDI1/NFYB/SC5D/SOD1 4 GO:0060425 lung morphogenesis 4/1036 50/18670 0.3008 0.7193 0.6352 TGFBR2/TNF/MAPK3/LIF 4 GO:0070741 response to interleukin-6 4/1036 50/18670 0.3008 0.7193 0.6352 NFKB1/IL6/CTR9/SPI1 4 GO:0106118 regulation of sterol biosynthetic process 4/1036 50/18670 0.3008 0.7193 0.6352 IDI1/NFYB/SC5D/SOD1 4 GO:0015893 drug transport 14/1036 214/18670 0.3012 0.7193 0.6352 MYC/FOLR3/ABAT/SLC25A32/CHRM5/SLC25A5/NTSR1/SLC7A5/SLC22A13/LMBRD1/RHAG/TCN2/IPCEF1/SLC1A3 14 GO:0009119 ribonucleoside metabolic process 7/1036 98/18670 0.3014 0.7193 0.6352 CMPK1/ENPP4/MFN1/UCKL1/AHCY/APOBEC3G/APRT 7 GO:0035821 modification of morphology or physiology of other organism 11/1036 164/18670 0.3023 0.7193 0.6352 CCL5/IFNG/LYZ/PTX3/HMGN2/PRF1/CHGA/RAB9A/ELANE/CTSG/PGLYRP4 11 GO:0046887 positive regulation of hormone secretion 9/1036 131/18670 0.3033 0.7193 0.6352 CD38/ABAT/OXCT1/DYNLL1/LRP1/TRH/AIMP1/GHRHR/NMU 9 GO:0051208 sequestering of calcium ion 9/1036 131/18670 0.3033 0.7193 0.6352 CXCL11/CLIC2/NTSR1/TRPM2/LCK/PLCB3/JPH3/MCOLN1/ATG5 9 GO:0055076 transition metal ion homeostasis 9/1036 131/18670 0.3033 0.7193 0.6352 MYC/SKP1/CUTC/LCK/SLC30A9/CUL1/SOD1/RHAG/SLC39A6 9 GO:0006687 glycosphingolipid metabolic process 5/1036 66/18670 0.3034 0.7193 0.6352 ST3GAL5/CREM/ESYT1/ARSA/CERK 5 GO:1904888 cranial skeletal system development 5/1036 66/18670 0.3034 0.7193 0.6352 TGFBR2/GNAS/INSIG1/EIF4A3/SIX2 5 GO:0001502 cartilage condensation 2/1036 20/18670 0.3056 0.7193 0.6352 BMPR1B/OTOR 2 GO:0002577 regulation of antigen processing and presentation 2/1036 20/18670 0.3056 0.7193 0.6352 HLA-DOB/WAS 2 GO:0007549 dosage compensation 2/1036 20/18670 0.3056 0.7193 0.6352 RBM15/RBM15B 2 GO:0007620 copulation 2/1036 20/18670 0.3056 0.7193 0.6352 ABAT/P2RX1 2 GO:0010592 positive regulation of lamellipodium assembly 2/1036 20/18670 0.3056 0.7193 0.6352 AUTS2/HDAC4 2 GO:0030220 platelet formation 2/1036 20/18670 0.3056 0.7193 0.6352 CLEC1B/ACTN1 2 GO:0032042 mitochondrial DNA metabolic process 2/1036 20/18670 0.3056 0.7193 0.6352 PARP1/FLCN 2 GO:0033617 mitochondrial respiratory chain complex IV assembly 2/1036 20/18670 0.3056 0.7193 0.6352 FASTKD3/OXA1L 2 GO:0033630 positive regulation of cell adhesion mediated by integrin 2/1036 20/18670 0.3056 0.7193 0.6352 CCL5/CD3E 2 GO:0034143 regulation of toll-like receptor 4 signaling pathway 2/1036 20/18670 0.3056 0.7193 0.6352 PTPN22/LBP 2 GO:0034393 positive regulation of smooth muscle cell apoptotic process 2/1036 20/18670 0.3056 0.7193 0.6352 IFNG/IL12B 2 GO:0042228 interleukin-8 biosynthetic process 2/1036 20/18670 0.3056 0.7193 0.6352 TNF/ELANE 2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process 2/1036 20/18670 0.3056 0.7193 0.6352 IFNG/LBP 2 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 2/1036 20/18670 0.3056 0.7193 0.6352 ANXA1/TBX21 2 GO:0046931 pore complex assembly 2/1036 20/18670 0.3056 0.7193 0.6352 NUP107/NUP205 2 GO:0050802 circadian sleep/wake cycle, sleep 2/1036 20/18670 0.3056 0.7193 0.6352 GHRHR/NMU 2 GO:0050860 negative regulation of T cell receptor signaling pathway 2/1036 20/18670 0.3056 0.7193 0.6352 PTPN22/LILRB4 2 GO:0060008 Sertoli cell differentiation 2/1036 20/18670 0.3056 0.7193 0.6352 RARA/ATRX 2 GO:0060039 pericardium development 2/1036 20/18670 0.3056 0.7193 0.6352 SOS1/HEG1 2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 2/1036 20/18670 0.3056 0.7193 0.6352 PSMC2/PSMC5 2 GO:0070262 peptidyl-serine dephosphorylation 2/1036 20/18670 0.3056 0.7193 0.6352 PPP1R16B/NCK1 2 GO:0070932 histone H3 deacetylation 2/1036 20/18670 0.3056 0.7193 0.6352 SFPQ/HDAC4 2 GO:0072234 metanephric nephron tubule development 2/1036 20/18670 0.3056 0.7193 0.6352 LIF/ACAT1 2 GO:0098780 response to mitochondrial depolarisation 2/1036 20/18670 0.3056 0.7193 0.6352 OPTN/ATG14 2 GO:1900017 positive regulation of cytokine production involved in inflammatory response 2/1036 20/18670 0.3056 0.7193 0.6352 TLR6/IL17B 2 GO:1902993 positive regulation of amyloid precursor protein catabolic process 2/1036 20/18670 0.3056 0.7193 0.6352 IFNG/TNF 2 GO:1905523 positive regulation of macrophage migration 2/1036 20/18670 0.3056 0.7193 0.6352 CCL5/MAPK3 2 GO:0007626 locomotory behavior 13/1036 198/18670 0.306 0.7193 0.6352 DDHD2/ABAT/NPC1/NTSR1/APH1B/PUM1/GLRA1/TRH/DSCAM/SOD1/NCOR1/GRIN2D/EFNB3 13 GO:0046890 regulation of lipid biosynthetic process 13/1036 198/18670 0.306 0.7193 0.6352 NFKB1/IFNG/IL1B/IDI1/INSIG1/TNF/ANXA1/NFYB/SPHK2/AKR1C3/SC5D/SOD1/ACSL3 13 GO:0051668 localization within membrane 10/1036 148/18670 0.3067 0.7193 0.6352 CD2/MADCAM1/ITGA4/INSIG1/FNTA/ATP1B1/RFTN1/DBN1/AP2B1/SEC24A 10 GO:0001881 receptor recycling 3/1036 35/18670 0.3071 0.7193 0.6352 OPTN/TRAT1/EHD3 3 GO:0001893 maternal placenta development 3/1036 35/18670 0.3071 0.7193 0.6352 MAPK3/LIF/TMED2 3 GO:0002701 negative regulation of production of molecular mediator of immune response 3/1036 35/18670 0.3071 0.7193 0.6352 CD96/TNF/TBX21 3 GO:0003230 cardiac atrium development 3/1036 35/18670 0.3071 0.7193 0.6352 SOS1/ACVR1/HEG1 3 GO:0032801 receptor catabolic process 3/1036 35/18670 0.3071 0.7193 0.6352 CAPN1/GPRASP1/AP2B1 3 GO:0042455 ribonucleoside biosynthetic process 3/1036 35/18670 0.3071 0.7193 0.6352 CMPK1/UCKL1/APRT 3 GO:0046131 pyrimidine ribonucleoside metabolic process 3/1036 35/18670 0.3071 0.7193 0.6352 CMPK1/UCKL1/APOBEC3G 3 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3/1036 35/18670 0.3071 0.7193 0.6352 GZMB/YWHAQ/PMAIP1 3 GO:1901385 regulation of voltage-gated calcium channel activity 3/1036 35/18670 0.3071 0.7193 0.6352 PDE4B/CACNB4/EHD3 3 GO:0070374 positive regulation of ERK1 and ERK2 cascade 14/1036 215/18670 0.3072 0.7193 0.6352 SLAMF1/CCL5/TNF/PTPN22/PHB2/LRP1/RASGRP1/MAPK3/PDE8A/CCL11/GPR183/CCL25/FGF18/CCL23 14 GO:0051321 meiotic cell cycle 16/1036 249/18670 0.3085 0.7217 0.6373 MYBL1/TUBGCP2/AURKC/CDC25B/PRKACB/LIF/FBXO5/PKMYT1/UBB/ATRX/RPA1/DUSP13/RBM7/TERF1/XRCC2/SMC2 16 GO:0071560 cellular response to transforming growth factor beta stimulus 16/1036 249/18670 0.3085 0.7217 0.6373 PARP1/TGFBR2/FLCN/USP9Y/HTRA1/ACVR1/FYN/FNTA/TGFBR3/BMPR1B/UBA52/STK11/CITED2/AMHR2/UBB/ZBTB7A 16 GO:0048525 negative regulation of viral process 7/1036 99/18670 0.3104 0.7252 0.6404 CCL5/PTX3/ZFP36/TNF/RSAD2/APOBEC3G/FCN1 7 GO:0070301 cellular response to hydrogen peroxide 7/1036 99/18670 0.3104 0.7252 0.6404 PCNA/IL6/TRPM2/ANXA1/PDE8A/SETX/CBX8 7 GO:1901570 fatty acid derivative biosynthetic process 7/1036 99/18670 0.3104 0.7252 0.6404 IL1B/ANXA1/CYP2C9/AKR1C3/ACSL3/ACSS3/ACAT1 7 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/1036 132/18670 0.3111 0.7262 0.6413 MYC/MALT1/CTSD/P2RX1/CYCS/TNF/LCK/HSPE1/PMAIP1 9 GO:0072329 monocarboxylic acid catabolic process 9/1036 132/18670 0.3111 0.7262 0.6413 ABAT/ABCD3/ACADM/LIPE/ETFA/SCP2/CYP4A11/ACAT1/CYP4F12 9 GO:0017038 protein import 13/1036 199/18670 0.3123 0.7287 0.6435 NUP107/IFNG/CBLB/RANBP6/PHB2/NUP85/CSE1L/AGK/TOMM20/PIK3R1/SIX2/NUP214/IPO7 13 GO:0006970 response to osmotic stress 6/1036 83/18670 0.313 0.7294 0.6441 ABCB1/KMO/TNF/SLC12A5/TLR3/AKR1B1 6 GO:0071277 cellular response to calcium ion 6/1036 83/18670 0.313 0.7294 0.6441 CPNE6/TRPM2/CPNE3/KCNH1/AKR1C3/MCOLN1 6 GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 6/1036 83/18670 0.313 0.7294 0.6441 TGFBR2/HTRA1/TGFBR3/UBA52/UBB/ZBTB7A 6 GO:0002712 regulation of B cell mediated immunity 4/1036 51/18670 0.3135 0.7294 0.6441 TNFSF13/TNF/MSH2/TBX21 4 GO:0002889 regulation of immunoglobulin mediated immune response 4/1036 51/18670 0.3135 0.7294 0.6441 TNFSF13/TNF/MSH2/TBX21 4 GO:0006213 pyrimidine nucleoside metabolic process 4/1036 51/18670 0.3135 0.7294 0.6441 DCK/CMPK1/UCKL1/APOBEC3G 4 GO:0045103 intermediate filament-based process 4/1036 51/18670 0.3135 0.7294 0.6441 SYNM/KRT9/PRPH/SOD1 4 GO:0008277 regulation of G protein-coupled receptor signaling pathway 10/1036 149/18670 0.314 0.7301 0.6447 CCL5/METAP1/GPRASP1/RGS1/CHGA/CRY1/FNTA/RIC8B/METAP2/FZD2 10 GO:0031647 regulation of protein stability 18/1036 284/18670 0.3141 0.7301 0.6447 CCT7/CDC37L1/DACT1/USP25/CCDC88C/DERL1/ASGR2/CCT2/TRIM44/RPS7/PHB2/PRKRA/XBP1/ATP1B1/USP18/RPL11/TRIM24/PIK3R1 18 GO:0021782 glial cell development 8/1036 116/18670 0.3153 0.7327 0.647 IL6/IFNG/IL1B/TNF/LRP1/CD9/SOD1/ROR1 8 GO:0019932 second-messenger-mediated signaling 27/1036 439/18670 0.3174 0.7331 0.6474 CXCL11/DYRK2/HINT1/CCR3/TRAT1/P2RX5/CLIC2/GNAS/CRTC3/ATP2A2/CXCR6/CHGA/ERBB3/TNF/TRPM2/CXCR4/PRKAR2B/ATP1B1/JPH3/HDAC4/PTGER4/GHRHR/MCOLN1/CD3E/ADNP/NDUFS4/GRIN2D 27 GO:0050770 regulation of axonogenesis 12/1036 183/18670 0.3176 0.7331 0.6474 ARHGAP4/PLXNB2/MAP2/LRP1/SEMA4G/SEMA3G/STK11/DBN1/DSCAM/NTN1/ADNP/EFNB3 12 GO:0001508 action potential 9/1036 133/18670 0.3188 0.7331 0.6474 ATP2A2/P2RX1/NTSR1/SCN10A/GLRA1/GPD1L/ATP1B1/RANGRF/KCNQ1 9 GO:0042770 signal transduction in response to DNA damage 9/1036 133/18670 0.3188 0.7331 0.6474 PCNA/BTG2/EEF1E1/ATR/DYRK3/PSMD10/DYRK1A/PMAIP1/ATRX 9 GO:0044242 cellular lipid catabolic process 14/1036 217/18670 0.3192 0.7331 0.6474 DDHD2/ABCD3/PNPLA6/ACADM/LRP1/LIPE/ETFA/SCP2/AKR1C3/PRDX6/GDPD3/CYP4A11/ACAT1/CYP4F12 14 GO:0046474 glycerophospholipid biosynthetic process 14/1036 217/18670 0.3192 0.7331 0.6474 DDHD2/CPNE6/CSNK2A2/STARD7/CPNE3/PIK3CA/GPD1L/DGKZ/AGPAT2/PIK3C2A/AGK/ACSL3/PGAP1/PIK3R1 14 GO:0071241 cellular response to inorganic substance 14/1036 217/18670 0.3192 0.7331 0.6474 PARP1/EIF4A3/MTR/CPNE6/TRPM2/CPNE3/GLRA1/MAPK3/KCNH1/AKR1C3/DAXX/SOD1/ATRX/MCOLN1 14 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 7/1036 100/18670 0.3194 0.7331 0.6474 GPR18/LTB4R/CHGA/CCKBR/CHRM2/LPAR6/P2RY10 7 GO:0030301 cholesterol transport 7/1036 100/18670 0.3194 0.7331 0.6474 NFKB1/CETP/LDLRAP1/NPC1/LRP1/SCP2/PON1 7 GO:0060079 excitatory postsynaptic potential 7/1036 100/18670 0.3194 0.7331 0.6474 P2RX5/EIF4A3/P2RX1/CHRNA2/GLRA1/P2RX6/GRIN2D 7 GO:0008016 regulation of heart contraction 16/1036 251/18670 0.3197 0.7331 0.6474 CLIC2/ATP2A2/CHGA/PDE4B/SCN10A/SLC8A2/GPD1L/ATP1B1/HDAC4/CHRM2/CACNB4/RANGRF/ATP2B2/EHD3/KCNQ1/NMU 16 GO:0071774 response to fibroblast growth factor 10/1036 150/18670 0.3213 0.7331 0.6474 CCL5/CEP57/HNRNPF/ZFP36/GCLC/TIA1/SULF1/MAPK3/SETX/FGF18 10 GO:0002755 MyD88-dependent toll-like receptor signaling pathway 3/1036 36/18670 0.3226 0.7331 0.6474 UBA52/TLR6/UBB 3 GO:0006882 cellular zinc ion homeostasis 3/1036 36/18670 0.3226 0.7331 0.6474 LCK/SLC30A9/SLC39A6 3 GO:0009112 nucleobase metabolic process 3/1036 36/18670 0.3226 0.7331 0.6474 CMPK1/PRPS1/APRT 3 GO:0010453 regulation of cell fate commitment 3/1036 36/18670 0.3226 0.7331 0.6474 IL12B/TBX21/IL23A 3 GO:0010742 macrophage derived foam cell differentiation 3/1036 36/18670 0.3226 0.7331 0.6474 NFKB1/PRKCH/CETP 3 GO:0016180 snRNA processing 3/1036 36/18670 0.3226 0.7331 0.6474 INTS12/INTS8/EXOSC8 3 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 3/1036 36/18670 0.3226 0.7331 0.6474 IL1B/TMEM204/FGF18 3 GO:0032205 negative regulation of telomere maintenance 3/1036 36/18670 0.3226 0.7331 0.6474 PARP1/TNKS/TERF1 3 GO:0032733 positive regulation of interleukin-10 production 3/1036 36/18670 0.3226 0.7331 0.6474 IL12B/IL23A/CD83 3 GO:0045740 positive regulation of DNA replication 3/1036 36/18670 0.3226 0.7331 0.6474 PCNA/ATRX/CDC7 3 GO:0045841 negative regulation of mitotic metaphase/anaphase transition 3/1036 36/18670 0.3226 0.7331 0.6474 PSMG2/NDC80/FBXO5 3 GO:0046627 negative regulation of insulin receptor signaling pathway 3/1036 36/18670 0.3226 0.7331 0.6474 IL1B/NCK1/PRKCQ 3 GO:0090077 foam cell differentiation 3/1036 36/18670 0.3226 0.7331 0.6474 NFKB1/PRKCH/CETP 3 GO:0097242 amyloid-beta clearance 3/1036 36/18670 0.3226 0.7331 0.6474 IFNG/TNF/LRP1 3 GO:0010507 negative regulation of autophagy 6/1036 84/18670 0.3229 0.7331 0.6474 NPC1/SCFD1/HERC1/PTPN22/PIK3CA/FEZ1 6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 6/1036 84/18670 0.3229 0.7331 0.6474 LAMP3/MICAL1/BIRC3/SIAH2/IGBP1/RPS6KA3 6 GO:0046889 positive regulation of lipid biosynthetic process 6/1036 84/18670 0.3229 0.7331 0.6474 IFNG/IL1B/TNF/ANXA1/SPHK2/ACSL3 6 GO:0050886 endocrine process 6/1036 84/18670 0.3229 0.7331 0.6474 IL1B/HSD11B2/GNAS/CRY1/AVPR1B/CTSG 6 GO:0097756 negative regulation of blood vessel diameter 6/1036 84/18670 0.3229 0.7331 0.6474 CD38/P2RX1/CHGA/HRH2/AVPR1B/PIK3C2A 6 GO:0010508 positive regulation of autophagy 8/1036 117/18670 0.3237 0.7331 0.6474 OPTN/IFNG/FLCN/SESN1/MAPK3/FYCO1/STK11/WAC 8 GO:0010906 regulation of glucose metabolic process 8/1036 117/18670 0.3237 0.7331 0.6474 DYRK2/DUSP12/PASK/RORA/CRY1/COX11/CLK2/PMAIP1 8 GO:0044262 cellular carbohydrate metabolic process 18/1036 286/18670 0.3247 0.7331 0.6474 DYRK2/DUSP12/PASK/RORA/ENOSF1/CD244/UGP2/NTSR1/CRY1/PPP1CC/COX11/GNE/PHKG1/CLK2/HDAC4/AKR1B1/PMAIP1/B3GNT2 18 GO:0010001 glial cell differentiation 14/1036 218/18670 0.3253 0.7331 0.6474 IL6/IFNG/IL1B/DAAM2/ERBB3/TNF/CXCR4/LRP1/SPINT1/MAPK3/LIF/CD9/SOD1/ROR1 14 GO:0016239 positive regulation of macroautophagy 5/1036 68/18670 0.3255 0.7331 0.6474 OPTN/SESN1/MAPK3/FYCO1/WAC 5 GO:0019915 lipid storage 5/1036 68/18670 0.3255 0.7331 0.6474 NFKB1/IL6/IL1B/CRY1/TNF 5 GO:0050891 multicellular organismal water homeostasis 5/1036 68/18670 0.3255 0.7331 0.6474 PRKACB/PRKAR2B/AKR1B1/CYP4A11/CYP4F12 5 GO:0071242 cellular response to ammonium ion 5/1036 68/18670 0.3255 0.7331 0.6474 CASP7/CHRM5/MAPK3/CHRM2/GABRB2 5 GO:0006998 nuclear envelope organization 4/1036 52/18670 0.3263 0.7331 0.6474 PARP11/VRK1/TMEM43/TOR1AIP1 4 GO:0032653 regulation of interleukin-10 production 4/1036 52/18670 0.3263 0.7331 0.6474 IL12B/TRIB2/IL23A/CD83 4 GO:0046580 negative regulation of Ras protein signal transduction 4/1036 52/18670 0.3263 0.7331 0.6474 FLCN/RASA1/TIMP2/HEG1 4 GO:0050885 neuromuscular process controlling balance 4/1036 52/18670 0.3263 0.7331 0.6474 HERC1/JPH3/SLC1A3/BCR 4 GO:0051438 regulation of ubiquitin-protein transferase activity 4/1036 52/18670 0.3263 0.7331 0.6474 RPS7/DNM1L/FBXO5/RPL11 4 GO:0099518 vesicle cytoskeletal trafficking 4/1036 52/18670 0.3263 0.7331 0.6474 KIFAP3/MAP2/RASGRP1/FYCO1 4 GO:2000677 regulation of transcription regulatory region DNA binding 4/1036 52/18670 0.3263 0.7331 0.6474 PARP1/IFNG/LIF/ZBTB7A 4 GO:0001956 positive regulation of neurotransmitter secretion 2/1036 21/18670 0.3265 0.7331 0.6474 KMO/DNM1L 2 GO:0003094 glomerular filtration 2/1036 21/18670 0.3265 0.7331 0.6474 EMP2/SULF1 2 GO:0006144 purine nucleobase metabolic process 2/1036 21/18670 0.3265 0.7331 0.6474 PRPS1/APRT 2 GO:0010829 negative regulation of glucose transmembrane transport 2/1036 21/18670 0.3265 0.7331 0.6474 IL1B/TNF 2 GO:0010988 regulation of low-density lipoprotein particle clearance 2/1036 21/18670 0.3265 0.7331 0.6474 LDLRAP1/KHSRP 2 GO:0017000 antibiotic biosynthetic process 2/1036 21/18670 0.3265 0.7331 0.6474 FYN/SOD1 2 GO:0021697 cerebellar cortex formation 2/1036 21/18670 0.3265 0.7331 0.6474 RORA/HERC1 2 GO:0032682 negative regulation of chemokine production 2/1036 21/18670 0.3265 0.7331 0.6474 IL6/ELANE 2 GO:0032891 negative regulation of organic acid transport 2/1036 21/18670 0.3265 0.7331 0.6474 ABAT/TRH 2 GO:0032986 protein-DNA complex disassembly 2/1036 21/18670 0.3265 0.7331 0.6474 MYC/SMARCD3 2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein 2/1036 21/18670 0.3265 0.7331 0.6474 IFNG/LIF 2 GO:0035162 embryonic hemopoiesis 2/1036 21/18670 0.3265 0.7331 0.6474 TGFBR2/IL3 2 GO:0035357 peroxisome proliferator activated receptor signaling pathway 2/1036 21/18670 0.3265 0.7331 0.6474 ASXL2/CITED2 2 GO:0035455 response to interferon-alpha 2/1036 21/18670 0.3265 0.7331 0.6474 LAMP3/IFIT2 2 GO:0036344 platelet morphogenesis 2/1036 21/18670 0.3265 0.7331 0.6474 CLEC1B/ACTN1 2 GO:0036499 PERK-mediated unfolded protein response 2/1036 21/18670 0.3265 0.7331 0.6474 NCK1/ATF3 2 GO:0036507 protein demannosylation 2/1036 21/18670 0.3265 0.7331 0.6474 EDEM1/MAN1A1 2 GO:0036508 protein alpha-1,2-demannosylation 2/1036 21/18670 0.3265 0.7331 0.6474 EDEM1/MAN1A1 2 GO:0042402 cellular biogenic amine catabolic process 2/1036 21/18670 0.3265 0.7331 0.6474 KMO/KYNU 2 GO:0042749 regulation of circadian sleep/wake cycle 2/1036 21/18670 0.3265 0.7331 0.6474 GHRHR/NMU 2 GO:0043153 entrainment of circadian clock by photoperiod 2/1036 21/18670 0.3265 0.7331 0.6474 CRY1/PPP1CC 2 GO:0045026 plasma membrane fusion 2/1036 21/18670 0.3265 0.7331 0.6474 FOLR3/CD9 2 GO:0046132 pyrimidine ribonucleoside biosynthetic process 2/1036 21/18670 0.3265 0.7331 0.6474 CMPK1/UCKL1 2 GO:0046827 positive regulation of protein export from nucleus 2/1036 21/18670 0.3265 0.7331 0.6474 IL1B/RIOK2 2 GO:0048026 positive regulation of mRNA splicing, via spliceosome 2/1036 21/18670 0.3265 0.7331 0.6474 TRA2B/PRDX6 2 GO:0050951 sensory perception of temperature stimulus 2/1036 21/18670 0.3265 0.7331 0.6474 NTSR1/CXCR4 2 GO:0051900 regulation of mitochondrial depolarization 2/1036 21/18670 0.3265 0.7331 0.6474 PARP1/GCLC 2 GO:0060972 left/right pattern formation 2/1036 21/18670 0.3265 0.7331 0.6474 HSPB11/CITED2 2 GO:0072111 cell proliferation involved in kidney development 2/1036 21/18670 0.3265 0.7331 0.6474 MYC/FLCN 2 GO:2000269 regulation of fibroblast apoptotic process 2/1036 21/18670 0.3265 0.7331 0.6474 PIK3CA/XRCC2 2 GO:2000737 negative regulation of stem cell differentiation 2/1036 21/18670 0.3265 0.7331 0.6474 LBH/HSPA9 2 GO:2000810 regulation of bicellular tight junction assembly 2/1036 21/18670 0.3265 0.7331 0.6474 PRKCH/TNF 2 GO:0000724 double-strand break repair via homologous recombination 9/1036 134/18670 0.3266 0.7331 0.6474 PARP1/SFPQ/PSMD14/WAS/RPA1/XRCC2/CDC7/MCM6/POLQ 9 GO:0018210 peptidyl-threonine modification 9/1036 134/18670 0.3266 0.7331 0.6474 DYRK2/TGFBR2/ACVR1/CSNK2A2/TNKS/VRK1/DYRK3/DYRK1A/CDC7 9 GO:0048565 digestive tract development 9/1036 134/18670 0.3266 0.7331 0.6474 TGFBR2/DACT1/ITGA6/TNF/HRH2/CCKBR/OTC/ITGB4/SIX2 9 GO:0046545 development of primary female sexual characteristics 7/1036 101/18670 0.3284 0.7367 0.6505 ARID5B/NUP107/PTX3/BMPR1B/AMHR2/UBB/SOD1 7 GO:0006470 protein dephosphorylation 20/1036 321/18670 0.3285 0.7367 0.6505 PTPN4/PPP1R17/DUSP2/DUSP12/PPP1R16B/PPP2R5C/NCK1/CDC25B/PPP1R8/CYCS/PPP1CC/TNF/PTPN22/PTPN7/LCK/STK11/DUSP21/IGBP1/DUSP13/DAPP1 20 GO:0055088 lipid homeostasis 10/1036 151/18670 0.3287 0.7367 0.6505 CETP/RORA/INSIG1/LDLRAP1/NPC1/ASGR2/XBP1/USF2/RCN3/SEC24A 10 GO:0050806 positive regulation of synaptic transmission 11/1036 168/18670 0.33 0.7394 0.6529 ABAT/KMO/NTSR1/TNF/DNM1L/CALB2/SLC8A2/CA7/NMU/GRIN2D/SLC1A3 11 GO:0007369 gastrulation 12/1036 185/18670 0.3308 0.741 0.6543 TGFBR2/CTR9/ITGA4/DLD/POGLUT1/ITGA7/ACVR1/HIRA/MBP/CLASP1/ITGB4/SIX2 12 GO:1903901 negative regulation of viral life cycle 6/1036 85/18670 0.3328 0.7452 0.658 CCL5/PTX3/TNF/RSAD2/APOBEC3G/FCN1 6 GO:0000725 recombinational repair 9/1036 135/18670 0.3345 0.7485 0.6609 PARP1/SFPQ/PSMD14/WAS/RPA1/XRCC2/CDC7/MCM6/POLQ 9 GO:0098656 anion transmembrane transport 18/1036 288/18670 0.3353 0.7493 0.6616 ABCB1/SLC35D1/SLC25A32/CLIC2/VDAC3/SLC38A1/NTSR1/SLC12A5/BEST1/SLC7A5/SLC35A1/LRRC8B/GLRA1/GABRB2/GABRP/SLC38A2/SLC20A1/SLC1A3 18 GO:0000187 activation of MAPK activity 10/1036 152/18670 0.336 0.7493 0.6616 IL1B/TNF/CXCR4/MAP4K5/MAPK3/UBA52/MAP4K2/DAXX/UBB/SOD1 10 GO:0015909 long-chain fatty acid transport 5/1036 69/18670 0.3367 0.7493 0.6616 ABCD3/NTSR1/ANXA1/ACSL3/PLA2G3 5 GO:0030166 proteoglycan biosynthetic process 5/1036 69/18670 0.3367 0.7493 0.6616 SLC35D1/CHST12/BMPR1B/CHPF2/FAM20B 5 GO:0034381 plasma lipoprotein particle clearance 5/1036 69/18670 0.3367 0.7493 0.6616 LIPA/LDLRAP1/NPC1/AP2B1/KHSRP 5 GO:0042698 ovulation cycle 5/1036 69/18670 0.3367 0.7493 0.6616 PCNA/PTX3/BMPR1B/TIMP4/ADNP 5 GO:0050728 negative regulation of inflammatory response 11/1036 169/18670 0.337 0.7493 0.6616 NFKB1/RORA/WFDC1/IL12B/PSMA1/CST7/ELANE/PTGER4/SOD1/SLAMF8/BCR 11 GO:0010522 regulation of calcium ion transport into cytosol 7/1036 102/18670 0.3375 0.7493 0.6616 CXCL11/P2RX5/CLIC2/FYN/NTSR1/JPH3/ATG5 7 GO:0030148 sphingolipid biosynthetic process 7/1036 102/18670 0.3375 0.7493 0.6616 ST3GAL5/P2RX1/TNF/CERS6/SPHK2/ALDH3B1/AGK 7 GO:0030308 negative regulation of cell growth 12/1036 186/18670 0.3375 0.7493 0.6616 FLCN/WFDC1/ARHGAP4/CAPRIN2/MAP2/SEMA4G/SPHK2/SEMA3G/STK11/RBBP7/NTN1/ADAM15 12 GO:0030278 regulation of ossification 13/1036 203/18670 0.3377 0.7493 0.6616 IL6/GNAS/ACVR1/TNF/BMPR1B/MAPK3/HDAC4/PDLIM7/PTGER4/FBXO5/ZBTB16/SIX2/GFRA4 13 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/1036 37/18670 0.338 0.7493 0.6616 BTG2/ZFP36/PABPC1 3 GO:0007099 centriole replication 3/1036 37/18670 0.338 0.7493 0.6616 TRIM37/NPM1/CEP76 3 GO:0030212 hyaluronan metabolic process 3/1036 37/18670 0.338 0.7493 0.6616 NFKB1/IL1B/IL15 3 GO:0032885 regulation of polysaccharide biosynthetic process 3/1036 37/18670 0.338 0.7493 0.6616 DYRK2/NFKB1/PASK 3 GO:0043243 positive regulation of protein complex disassembly 3/1036 37/18670 0.338 0.7493 0.6616 TNF/FYCO1/SETX 3 GO:0045730 respiratory burst 3/1036 37/18670 0.338 0.7493 0.6616 SLAMF8/BCR/LBP 3 GO:0046006 regulation of activated T cell proliferation 3/1036 37/18670 0.338 0.7493 0.6616 IL12B/IL23A/CLC 3 GO:0048846 axon extension involved in axon guidance 3/1036 37/18670 0.338 0.7493 0.6616 SEMA4G/SEMA3G/DSCAM 3 GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 3/1036 37/18670 0.338 0.7493 0.6616 PSMG2/NDC80/FBXO5 3 GO:1902284 neuron projection extension involved in neuron projection guidance 3/1036 37/18670 0.338 0.7493 0.6616 SEMA4G/SEMA3G/DSCAM 3 GO:2000249 regulation of actin cytoskeleton reorganization 3/1036 37/18670 0.338 0.7493 0.6616 TRPM2/CD2AP/HAX1 3 GO:2000403 positive regulation of lymphocyte migration 3/1036 37/18670 0.338 0.7493 0.6616 CCL5/MADCAM1/ITGA4 3 GO:0031122 cytoplasmic microtubule organization 4/1036 53/18670 0.3391 0.75 0.6623 TUBGCP2/CCDC88C/PCM1/CLASP1 4 GO:0031638 zymogen activation 4/1036 53/18670 0.3391 0.75 0.6623 PGK1/PLGRKT/F12/CYFIP2 4 GO:0045840 positive regulation of mitotic nuclear division 4/1036 53/18670 0.3391 0.75 0.6623 IL1A/IL1B/ANAPC5/PHB2 4 GO:1901185 negative regulation of ERBB signaling pathway 4/1036 53/18670 0.3391 0.75 0.6623 CBLB/ARHGEF7/EPS15L1/RNF115 4 GO:1902475 L-alpha-amino acid transmembrane transport 4/1036 53/18670 0.3391 0.75 0.6623 SLC38A1/NTSR1/SLC7A5/SLC1A3 4 GO:0001952 regulation of cell-matrix adhesion 8/1036 119/18670 0.3405 0.7527 0.6647 RASA1/LRP1/EMP2/CLASP1/CCL25/ADAM15/CD3E/PIK3R1 8 GO:0032868 response to insulin 17/1036 272/18670 0.3416 0.755 0.6667 PARP1/SOS1/IL1B/NCK1/CAT/HSD11B2/PRKCQ/GCLC/CRY1/XBP1/TBC1D4/PIK3CA/OTC/PIK3C2A/GHRHR/APRT/PIK3R1 17 GO:0071559 response to transforming growth factor beta 16/1036 255/18670 0.3424 0.7561 0.6676 PARP1/TGFBR2/FLCN/USP9Y/HTRA1/ACVR1/FYN/FNTA/TGFBR3/BMPR1B/UBA52/STK11/CITED2/AMHR2/UBB/ZBTB7A 16 GO:0001776 leukocyte homeostasis 6/1036 86/18670 0.3428 0.7561 0.6676 SOS1/IL6/PDE4B/ANXA1/GPR183/PMAIP1 6 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 6/1036 86/18670 0.3428 0.7561 0.6676 P2RX1/CYCS/TNF/LCK/HSPE1/PMAIP1 6 GO:0034637 cellular carbohydrate biosynthetic process 6/1036 86/18670 0.3428 0.7561 0.6676 DYRK2/PASK/UGP2/PHKG1/AKR1B1/B3GNT2 6 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 6/1036 86/18670 0.3428 0.7561 0.6676 SOS1/CBLB/ARHGEF7/EPS15L1/DOK1/RNF115 6 GO:0035637 multicellular organismal signaling 13/1036 204/18670 0.3441 0.7578 0.6691 CHRM5/ATP2A2/P2RX1/SCN10A/SLC8A2/GLRA1/ATP1B1/CACNB4/RANGRF/ATP2B2/EHD3/SOD1/KCNQ1 13 GO:0042063 gliogenesis 18/1036 290/18670 0.3461 0.7578 0.6691 IL6/IFNG/IL1B/PRKCH/DAAM2/ERBB3/PPP1CC/TNF/CXCR4/ANXA1/LRP1/SPINT1/MAPK3/LIF/CD9/GPR183/SOD1/ROR1 18 GO:0051650 establishment of vesicle localization 18/1036 290/18670 0.3461 0.7578 0.6691 ITGA4/CTSC/ATP2A2/TMEM230/P2RX1/SCFD1/SV2A/KIFAP3/MAP2/RASGRP1/DNM1L/FYCO1/CHRM2/MAP4K2/CLASP1/GOSR1/SEC24A/TMED2 18 GO:0000423 mitophagy 2/1036 22/18670 0.3471 0.7578 0.6691 OPTN/ATG14 2 GO:0007398 ectoderm development 2/1036 22/18670 0.3471 0.7578 0.6691 ITGA6/EDA2R 2 GO:0009220 pyrimidine ribonucleotide biosynthetic process 2/1036 22/18670 0.3471 0.7578 0.6691 CMPK1/UCKL1 2 GO:0010155 regulation of proton transport 2/1036 22/18670 0.3471 0.7578 0.6691 PHB2/SPHK2 2 GO:0010869 regulation of receptor biosynthetic process 2/1036 22/18670 0.3471 0.7578 0.6691 IFNG/SEC24A 2 GO:0016556 mRNA modification 2/1036 22/18670 0.3471 0.7578 0.6691 TRMT61B/CBLL1 2 GO:0019883 antigen processing and presentation of endogenous antigen 2/1036 22/18670 0.3471 0.7578 0.6691 CD1A/ATG5 2 GO:0021516 dorsal spinal cord development 2/1036 22/18670 0.3471 0.7578 0.6691 DAAM2/LHX3 2 GO:0031281 positive regulation of cyclase activity 2/1036 22/18670 0.3471 0.7578 0.6691 MAPK3/TIMP2 2 GO:0034311 diol metabolic process 2/1036 22/18670 0.3471 0.7578 0.6691 QDPR/SPHK2 2 GO:0035024 negative regulation of Rho protein signal transduction 2/1036 22/18670 0.3471 0.7578 0.6691 FLCN/HEG1 2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 2/1036 22/18670 0.3471 0.7578 0.6691 VPS37B/RNF115 2 GO:0043496 regulation of protein homodimerization activity 2/1036 22/18670 0.3471 0.7578 0.6691 AIDA/ITGA4 2 GO:0045723 positive regulation of fatty acid biosynthetic process 2/1036 22/18670 0.3471 0.7578 0.6691 IL1B/ANXA1 2 GO:0046058 cAMP metabolic process 2/1036 22/18670 0.3471 0.7578 0.6691 PDE4B/PDE8A 2 GO:0046339 diacylglycerol metabolic process 2/1036 22/18670 0.3471 0.7578 0.6691 LIPE/DGKZ 2 GO:0071379 cellular response to prostaglandin stimulus 2/1036 22/18670 0.3471 0.7578 0.6691 PTGER4/AKR1C3 2 GO:0071404 cellular response to low-density lipoprotein particle stimulus 2/1036 22/18670 0.3471 0.7578 0.6691 NPC1/CD9 2 GO:0071577 zinc ion transmembrane transport 2/1036 22/18670 0.3471 0.7578 0.6691 TRPM2/SLC39A6 2 GO:0090189 regulation of branching involved in ureteric bud morphogenesis 2/1036 22/18670 0.3471 0.7578 0.6691 MAGED1/SIX2 2 GO:0097205 renal filtration 2/1036 22/18670 0.3471 0.7578 0.6691 EMP2/SULF1 2 GO:1901984 negative regulation of protein acetylation 2/1036 22/18670 0.3471 0.7578 0.6691 SPI1/ATG5 2 GO:0032720 negative regulation of tumor necrosis factor production 5/1036 70/18670 0.3478 0.7589 0.6702 SLAMF1/GPR18/PTPN22/RARA/LBP 5 GO:0022612 gland morphogenesis 8/1036 120/18670 0.3489 0.7607 0.6717 TGFBR2/CAPN1/TNF/PHB2/XBP1/SULF1/CCL11/NTN1 8 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 8/1036 120/18670 0.3489 0.7607 0.6717 RCHY1/CTSC/PSMC2/GCLC/RBX1/TRIB2/EDEM1/PSMD10 8 GO:0031348 negative regulation of defense response 15/1036 239/18670 0.3491 0.7608 0.6718 CD96/NFKB1/C1QBP/RORA/WFDC1/IL12B/PSMA1/HTRA1/CST7/ELANE/PTGER4/SOD1/SLAMF8/GPATCH3/BCR 15 GO:0061025 membrane fusion 10/1036 154/18670 0.3509 0.7645 0.6751 FOLR3/CXCR4/MFN1/ANXA1/STX10/STX8/DNM1L/TBC1D4/CD9/GOSR1 10 GO:0016241 regulation of macroautophagy 11/1036 171/18670 0.3511 0.7646 0.6751 OPTN/CAPN1/NPC1/SESN1/SCFD1/EXOC7/PIK3CA/MAPK3/FYCO1/WAC/FEZ1 11 GO:0001101 response to acid chemical 21/1036 343/18670 0.3524 0.7657 0.6762 CD38/PCNA/CAT/SESN1/GCLC/FYN/TNF/TGFBR3/PHB2/CLK2/XBP1/RARA/GLRA1/PON1/OTC/AKR1B1/PTGER4/CD9/AKR1C3/TOMM20/SETX 21 GO:0051781 positive regulation of cell division 6/1036 87/18670 0.3528 0.7657 0.6762 LBH/IL1A/IL1B/AURKC/CDC25B/CAT 6 GO:0006040 amino sugar metabolic process 3/1036 38/18670 0.3535 0.7657 0.6762 GNE/UAP1L1/GFPT1 3 GO:0006298 mismatch repair 3/1036 38/18670 0.3535 0.7657 0.6762 PCNA/MSH2/RPA1 3 GO:0006656 phosphatidylcholine biosynthetic process 3/1036 38/18670 0.3535 0.7657 0.6762 CSNK2A2/STARD7/ACSL3 3 GO:0015804 neutral amino acid transport 3/1036 38/18670 0.3535 0.7657 0.6762 SLC38A1/SLC7A5/SLC38A2 3 GO:0019068 virion assembly 3/1036 38/18670 0.3535 0.7657 0.6762 UBA52/VPS37B/UBB 3 GO:0045022 early endosome to late endosome transport 3/1036 38/18670 0.3535 0.7657 0.6762 STX8/EMP2/MAPK3 3 GO:0055069 zinc ion homeostasis 3/1036 38/18670 0.3535 0.7657 0.6762 LCK/SLC30A9/SLC39A6 3 GO:0071867 response to monoamine 3/1036 38/18670 0.3535 0.7657 0.6762 PDE4B/MAPK3/KCNQ1 3 GO:0071869 response to catecholamine 3/1036 38/18670 0.3535 0.7657 0.6762 PDE4B/MAPK3/KCNQ1 3 GO:0097352 autophagosome maturation 3/1036 38/18670 0.3535 0.7657 0.6762 ATG14/FYCO1/MCOLN1 3 GO:1900077 negative regulation of cellular response to insulin stimulus 3/1036 38/18670 0.3535 0.7657 0.6762 IL1B/NCK1/PRKCQ 3 GO:0006892 post-Golgi vesicle-mediated transport 7/1036 104/18670 0.3557 0.77 0.6799 OPTN/SCFD1/CCDC91/ANXA13/C16orf70/EHD3/ACSL3 7 GO:1901800 positive regulation of proteasomal protein catabolic process 7/1036 104/18670 0.3557 0.77 0.6799 RCHY1/PSMC2/GCLC/RBX1/TRIB2/EDEM1/PSMD10 7 GO:0030048 actin filament-based movement 9/1036 138/18670 0.3582 0.7743 0.6837 MYL1/PDE4B/TNNI1/WAS/EMP2/MYO9B/PARVA/GPD1L/KCNQ1 9 GO:0030324 lung development 11/1036 172/18670 0.3582 0.7743 0.6837 TGFBR2/ADAMTS2/LIPA/TNF/HSPB11/LHX3/MAPK3/LIF/HEG1/FGF18/RCN3 11 GO:0032874 positive regulation of stress-activated MAPK cascade 11/1036 172/18670 0.3582 0.7743 0.6837 SLAMF1/IL1B/TNF/IL36A/RASGRP1/TLR3/MAP4K5/MAP4K2/TLR6/DAXX/EDA2R 11 GO:0010977 negative regulation of neuron projection development 10/1036 155/18670 0.3584 0.7744 0.6838 CD38/ARHGAP4/MAP2/LRP1/SEMA4G/SEMA3G/NTN1/PAQR3/EFNB3/CRMP1 10 GO:0051346 negative regulation of hydrolase activity 28/1036 466/18670 0.3587 0.7749 0.6843 RHOH/PPP1R17/PTX3/WFDC1/LAMP3/PPP1R8/MICAL1/BIRC3/TNF/SIAH2/RECK/GZMA/ANXA1/MAP2/SPINT1/OXA1L/PEBP1/CST7/TIMP2/SPHK2/TIMP4/CSN2/IGBP1/PKMYT1/MPHOSPH10/RPS6KA3/TERF1/TMED2 28 GO:0033692 cellular polysaccharide biosynthetic process 5/1036 71/18670 0.359 0.7751 0.6844 DYRK2/PASK/UGP2/PHKG1/B3GNT2 5 GO:0046486 glycerolipid metabolic process 25/1036 414/18670 0.3599 0.7764 0.6856 DDHD2/ATG14/CHRM5/CETP/CAT/INSIG1/CPNE6/PNPLA6/CSNK2A2/LIPE/STARD7/CPNE3/PIK3CA/GPD1L/DGKZ/PON1/AGPAT2/PIK3C2A/PRDX6/AGK/ACSL3/GDPD3/PLA2G3/PGAP1/PIK3R1 25 GO:0042113 B cell activation 19/1036 310/18670 0.3607 0.7764 0.6856 CD38/ITM2A/IL6/POU2F2/MALT1/ITGA4/TNFSF13/MSH2/TBX21/XBP1/HDAC4/LYL1/GPR183/IGBP1/AKAP17A/SLAMF8/PIK3R1/TRBC1/ZBTB7A 19 GO:0034103 regulation of tissue remodeling 6/1036 88/18670 0.3628 0.7764 0.6856 CD38/IL6/IL12B/IL23A/IL15/BCR 6 GO:0048644 muscle organ morphogenesis 6/1036 88/18670 0.3628 0.7764 0.6856 ARID5B/TNNI1/TGFBR3/LIF/HEG1/FZD2 6 GO:1903725 regulation of phospholipid metabolic process 6/1036 88/18670 0.3628 0.7764 0.6856 ATG14/CHRM5/CCKBR/DGKZ/ACSL3/PIK3R1 6 GO:0030073 insulin secretion 13/1036 207/18670 0.3634 0.7764 0.6856 CD38/ABAT/CCL5/IFNG/IL1B/OXCT1/SLC25A5/DYNLL1/CHGA/TNF/ANXA1/LRP1/TRH 13 GO:0060759 regulation of response to cytokine stimulus 12/1036 190/18670 0.3644 0.7764 0.6856 CCL5/IL6/IFNG/BIRC3/TNF/TRIM44/CXCR4/TXK/PIAS4/AGPAT2/USP18/IL3 12 GO:0002886 regulation of myeloid leukocyte mediated immunity 4/1036 55/18670 0.3647 0.7764 0.6856 DDX1/DDX21/SPHK2/BCR 4 GO:0006576 cellular biogenic amine metabolic process 4/1036 55/18670 0.3647 0.7764 0.6856 ODC1/KMO/TRH/KYNU 4 GO:0016233 telomere capping 4/1036 55/18670 0.3647 0.7764 0.6856 PRKCQ/MAPK3/TNKS/TERF1 4 GO:0032613 interleukin-10 production 4/1036 55/18670 0.3647 0.7764 0.6856 IL12B/TRIB2/IL23A/CD83 4 GO:0044273 sulfur compound catabolic process 4/1036 55/18670 0.3647 0.7764 0.6856 ADO/AHCY/CBS/ACAT1 4 GO:0046456 icosanoid biosynthetic process 4/1036 55/18670 0.3647 0.7764 0.6856 IL1B/ANXA1/CYP2C9/AKR1C3 4 GO:0061098 positive regulation of protein tyrosine kinase activity 4/1036 55/18670 0.3647 0.7764 0.6856 CCL5/FYN/ERBB3/NCAPG2 4 GO:0001841 neural tube formation 7/1036 105/18670 0.3649 0.7764 0.6856 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0015748 organophosphate ester transport 7/1036 105/18670 0.3649 0.7764 0.6856 ABCB1/SLC25A32/CETP/SLC25A5/ATP8A1/STARD7/SCP2 7 GO:0033138 positive regulation of peptidyl-serine phosphorylation 7/1036 105/18670 0.3649 0.7764 0.6856 IL6/IFNG/TNF/CAPRIN2/PIK3CA/LIF/HAX1 7 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11/1036 173/18670 0.3653 0.7764 0.6856 SLAMF1/IL1B/TNF/IL36A/RASGRP1/TLR3/MAP4K5/MAP4K2/TLR6/DAXX/EDA2R 11 GO:0019079 viral genome replication 8/1036 122/18670 0.3659 0.7764 0.6856 CCL5/CXCR6/TNF/PCBP1/RSAD2/PABPC1/APOBEC3G/ATG5 8 GO:0034101 erythrocyte homeostasis 8/1036 122/18670 0.3659 0.7764 0.6856 HSPA9/ZFP36/TGFBR3/DYRK3/SPI1/RHAG/NCAPG2/ZBTB7A 8 GO:1990778 protein localization to cell periphery 19/1036 311/18670 0.366 0.7764 0.6856 OPTN/IFNG/PRKCH/RAPGEF6/LDLRAP1/TNF/GORASP2/EHD2/LRP1/STX8/EMP2/ATP1B1/ANXA13/RANGRF/C16orf70/EHD3/ACSL3/PIK3R1/TMED2 19 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 9/1036 139/18670 0.3661 0.7764 0.6856 CD247/NCK1/FYN/WAS/CYFIP2/PIK3CA/MAPK3/ELMO2/PIK3R1 9 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 9/1036 139/18670 0.3661 0.7764 0.6856 CD247/NCK1/FYN/WAS/CYFIP2/PIK3CA/MAPK3/ELMO2/PIK3R1 9 GO:0051588 regulation of neurotransmitter transport 9/1036 139/18670 0.3661 0.7764 0.6856 ABAT/ATP2A2/KMO/P2RX1/NTSR1/SV2A/DNM1L/TRH/CHRM2 9 GO:0006541 glutamine metabolic process 2/1036 23/18670 0.3676 0.7764 0.6856 ASNSD1/GFPT1 2 GO:0007064 mitotic sister chromatid cohesion 2/1036 23/18670 0.3676 0.7764 0.6856 TNKS/ATRX 2 GO:0007530 sex determination 2/1036 23/18670 0.3676 0.7764 0.6856 CITED2/SRY 2 GO:0007617 mating behavior 2/1036 23/18670 0.3676 0.7764 0.6856 UBE2Q1/HDAC4 2 GO:0009310 amine catabolic process 2/1036 23/18670 0.3676 0.7764 0.6856 KMO/KYNU 2 GO:0010528 regulation of transposition 2/1036 23/18670 0.3676 0.7764 0.6856 MYBL1/APOBEC3G 2 GO:0010529 negative regulation of transposition 2/1036 23/18670 0.3676 0.7764 0.6856 MYBL1/APOBEC3G 2 GO:0015813 L-glutamate transmembrane transport 2/1036 23/18670 0.3676 0.7764 0.6856 NTSR1/SLC1A3 2 GO:0016578 histone deubiquitination 2/1036 23/18670 0.3676 0.7764 0.6856 SART3/USP16 2 GO:0022410 circadian sleep/wake cycle process 2/1036 23/18670 0.3676 0.7764 0.6856 GHRHR/NMU 2 GO:0032703 negative regulation of interleukin-2 production 2/1036 23/18670 0.3676 0.7764 0.6856 ZFP36/TBX21 2 GO:0032799 low-density lipoprotein receptor particle metabolic process 2/1036 23/18670 0.3676 0.7764 0.6856 AP2B1/SEC24A 2 GO:0032959 inositol trisphosphate biosynthetic process 2/1036 23/18670 0.3676 0.7764 0.6856 PLCL1/PLCB3 2 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein 2/1036 23/18670 0.3676 0.7764 0.6856 IFNG/LIF 2 GO:0034695 response to prostaglandin E 2/1036 23/18670 0.3676 0.7764 0.6856 TGFBR3/PTGER4 2 GO:0036037 CD8-positive, alpha-beta T cell activation 2/1036 23/18670 0.3676 0.7764 0.6856 GPR18/SATB1 2 GO:0051882 mitochondrial depolarization 2/1036 23/18670 0.3676 0.7764 0.6856 PARP1/GCLC 2 GO:0060055 angiogenesis involved in wound healing 2/1036 23/18670 0.3676 0.7764 0.6856 CXCR4/XBP1 2 GO:0071294 cellular response to zinc ion 2/1036 23/18670 0.3676 0.7764 0.6856 PARP1/GLRA1 2 GO:0071305 cellular response to vitamin D 2/1036 23/18670 0.3676 0.7764 0.6856 IL15/TRIM24 2 GO:0072170 metanephric tubule development 2/1036 23/18670 0.3676 0.7764 0.6856 LIF/ACAT1 2 GO:0072215 regulation of metanephros development 2/1036 23/18670 0.3676 0.7764 0.6856 MYC/LIF 2 GO:0072243 metanephric nephron epithelium development 2/1036 23/18670 0.3676 0.7764 0.6856 LIF/ACAT1 2 GO:0089718 amino acid import across plasma membrane 2/1036 23/18670 0.3676 0.7764 0.6856 NTSR1/SLC1A3 2 GO:1901889 negative regulation of cell junction assembly 2/1036 23/18670 0.3676 0.7764 0.6856 TNF/LRP1 2 GO:1903861 positive regulation of dendrite extension 2/1036 23/18670 0.3676 0.7764 0.6856 CPNE6/CXCR4 2 GO:0033157 regulation of intracellular protein transport 14/1036 225/18670 0.3685 0.7764 0.6856 IFNG/IL1B/INSIG1/FYN/ZFAND1/CSNK2A2/EDEM1/ICE1/PCM1/RIOK2/HAX1/MFF/PIK3R1/UBE2J1 14 GO:0007257 activation of JUN kinase activity 3/1036 39/18670 0.3689 0.7764 0.6856 MAP4K5/MAP4K2/DAXX 3 GO:0008207 C21-steroid hormone metabolic process 3/1036 39/18670 0.3689 0.7764 0.6856 FDX1/AKR1B1/AKR1C3 3 GO:0009072 aromatic amino acid family metabolic process 3/1036 39/18670 0.3689 0.7764 0.6856 KMO/QDPR/KYNU 3 GO:0010761 fibroblast migration 3/1036 39/18670 0.3689 0.7764 0.6856 ARID5B/ARHGAP4/ARHGEF7 3 GO:0010874 regulation of cholesterol efflux 3/1036 39/18670 0.3689 0.7764 0.6856 CETP/LRP1/PON1 3 GO:0030204 chondroitin sulfate metabolic process 3/1036 39/18670 0.3689 0.7764 0.6856 SLC35D1/CHST12/CHPF2 3 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 3/1036 39/18670 0.3689 0.7764 0.6856 LBH/PARP1/PHB2 3 GO:0045684 positive regulation of epidermis development 3/1036 39/18670 0.3689 0.7764 0.6856 PRKCH/TNF/NCOA3 3 GO:0051930 regulation of sensory perception of pain 3/1036 39/18670 0.3689 0.7764 0.6856 NTSR1/NMU/GRIN2D 3 GO:0055090 acylglycerol homeostasis 3/1036 39/18670 0.3689 0.7764 0.6856 CETP/RORA/XBP1 3 GO:0070328 triglyceride homeostasis 3/1036 39/18670 0.3689 0.7764 0.6856 CETP/RORA/XBP1 3 GO:1902116 negative regulation of organelle assembly 3/1036 39/18670 0.3689 0.7764 0.6856 TRIM37/SCFD1/FEZ1 3 GO:2000816 negative regulation of mitotic sister chromatid separation 3/1036 39/18670 0.3689 0.7764 0.6856 PSMG2/NDC80/FBXO5 3 GO:0006635 fatty acid beta-oxidation 5/1036 72/18670 0.3701 0.7775 0.6866 ABCD3/ACADM/ETFA/SCP2/ACAT1 5 GO:0019226 transmission of nerve impulse 5/1036 72/18670 0.3701 0.7775 0.6866 CHRM5/P2RX1/SCN10A/GLRA1/SOD1 5 GO:0090114 COPII-coated vesicle budding 5/1036 72/18670 0.3701 0.7775 0.6866 CTSC/INSIG1/SCFD1/SEC24A/TMED2 5 GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 5/1036 72/18670 0.3701 0.7775 0.6866 SLAMF1/GPR18/PTPN22/RARA/LBP 5 GO:1903747 regulation of establishment of protein localization to mitochondrion 5/1036 72/18670 0.3701 0.7775 0.6866 GZMB/CSNK2A2/YWHAQ/PMAIP1/HAX1 5 GO:0071478 cellular response to radiation 12/1036 191/18670 0.3712 0.7794 0.6882 PCNA/PARP1/MYC/METAP1/CRY1/FNTA/ATR/METAP2/NPM1/STK11/TRPM1/PIK3R1 12 GO:0008654 phospholipid biosynthetic process 16/1036 260/18670 0.3713 0.7794 0.6882 DDHD2/IDI1/CPNE6/CSNK2A2/STARD7/CPNE3/PIK3CA/GPD1L/SPHK2/DGKZ/AGPAT2/PIK3C2A/AGK/ACSL3/PGAP1/PIK3R1 16 GO:0060021 roof of mouth development 6/1036 89/18670 0.3729 0.782 0.6905 ARID5B/SOS1/TGFBR2/INSIG1/TGFBR3/FZD2 6 GO:1901019 regulation of calcium ion transmembrane transporter activity 6/1036 89/18670 0.3729 0.782 0.6905 CLIC2/PDE4B/ATP1B1/JPH3/CACNB4/EHD3 6 GO:0050768 negative regulation of neurogenesis 18/1036 295/18670 0.3732 0.7825 0.6909 CD38/IL6/IL1B/DAAM2/ARHGAP4/TNF/MAP2/LRP1/SEMA4G/PCM1/TLX3/SEMA3G/CCL11/HMG20A/NTN1/PAQR3/EFNB3/CRMP1 18 GO:0002062 chondrocyte differentiation 8/1036 123/18670 0.3744 0.7845 0.6928 TGFBR2/BMPR1B/MEX3C/SULF1/ZBTB16/FGF18/SIX2/MAF 8 GO:0051235 maintenance of location 20/1036 330/18670 0.3745 0.7845 0.6928 CXCL11/NFKB1/IL6/IL1B/SKP1/CLIC2/INSIG1/SUPT7L/NTSR1/CRY1/TNF/TRPM2/SYNE1/LCK/PLCB3/JPH3/DBN1/PSMD10/MCOLN1/ATG5 20 GO:0010332 response to gamma radiation 4/1036 56/18670 0.3775 0.7896 0.6972 PARP1/MYC/ATR/XRCC2 4 GO:0065002 intracellular protein transmembrane transport 4/1036 56/18670 0.3775 0.7896 0.6972 TRAM1/AGK/TOMM20/BCR 4 GO:0086065 cell communication involved in cardiac conduction 4/1036 56/18670 0.3775 0.7896 0.6972 SCN10A/ATP1B1/RANGRF/KCNQ1 4 GO:0009101 glycoprotein biosynthetic process 21/1036 348/18670 0.3775 0.7896 0.6972 ST3GAL5/ITM2A/SLC35D1/ALG13/CHST12/POGLUT1/NPC1/ASGR2/MUC2/BMPR1B/CHPF2/ASGR1/FAM20B/IL15/MAN1A1/MGAT2/GALNT10/B3GNT2/ABO/UBE2J1/GFPT1 21 GO:0048839 inner ear development 12/1036 192/18670 0.378 0.7904 0.6979 INSIG1/LRIG1/LHX3/GABRB2/SOD1/ROR1/NTN1/KCNQ1/FZD2/MAF/BCR/ATG5 12 GO:0006457 protein folding 14/1036 227/18670 0.381 0.7957 0.7026 CCT7/CDC37L1/SACS/HSPA9/DERL1/HSPB6/CCT2/CSNK2A2/VBP1/DNAJB1/HSPE1/HSPA14/PFDN2/TBCA 14 GO:0003208 cardiac ventricle morphogenesis 5/1036 73/18670 0.3813 0.7957 0.7026 TGFBR2/TNNI1/TGFBR3/SMARCD3/HEG1 5 GO:0043627 response to estrogen 5/1036 73/18670 0.3813 0.7957 0.7026 TGFBR2/RARA/CITED2/GHRHR/TRIM24 5 GO:0045685 regulation of glial cell differentiation 5/1036 73/18670 0.3813 0.7957 0.7026 IL6/DAAM2/CXCR4/SPINT1/LIF 5 GO:0060350 endochondral bone morphogenesis 5/1036 73/18670 0.3813 0.7957 0.7026 TGFBR2/GNAS/BMPR1B/RARA/FGF18 5 GO:0009100 glycoprotein metabolic process 25/1036 419/18670 0.3829 0.7967 0.7035 ST3GAL5/ITM2A/SLC35D1/PTX3/ALG13/CHST12/POGLUT1/NPC1/ASGR2/MUC2/BMPR1B/CHPF2/SGSH/ASGR1/EDEM1/SULF1/FAM20B/IL15/MAN1A1/MGAT2/GALNT10/B3GNT2/ABO/UBE2J1/GFPT1 25 GO:0009953 dorsal/ventral pattern formation 6/1036 90/18670 0.3829 0.7967 0.7035 AIDA/FKBP8/PRKACB/ACVR1/LHX3/BMPR1B 6 GO:0042475 odontogenesis of dentin-containing tooth 6/1036 90/18670 0.3829 0.7967 0.7035 ITGA6/HTRA1/SCN10A/BCL11B/AMBN/ITGB4 6 GO:0001990 regulation of systemic arterial blood pressure by hormone 3/1036 40/18670 0.3842 0.7967 0.7035 HSD11B2/AVPR1B/CTSG 3 GO:0006734 NADH metabolic process 3/1036 40/18670 0.3842 0.7967 0.7035 MDH1/PGK1/PFKP 3 GO:0009187 cyclic nucleotide metabolic process 3/1036 40/18670 0.3842 0.7967 0.7035 RORA/PDE4B/PDE8A 3 GO:0009395 phospholipid catabolic process 3/1036 40/18670 0.3842 0.7967 0.7035 PNPLA6/PRDX6/GDPD3 3 GO:0050832 defense response to fungus 3/1036 40/18670 0.3842 0.7967 0.7035 CHGA/ELANE/CTSG 3 GO:0051931 regulation of sensory perception 3/1036 40/18670 0.3842 0.7967 0.7035 NTSR1/NMU/GRIN2D 3 GO:0090184 positive regulation of kidney development 3/1036 40/18670 0.3842 0.7967 0.7035 MYC/MAGED1/LIF 3 GO:0098534 centriole assembly 3/1036 40/18670 0.3842 0.7967 0.7035 TRIM37/NPM1/CEP76 3 GO:1905819 negative regulation of chromosome separation 3/1036 40/18670 0.3842 0.7967 0.7035 PSMG2/NDC80/FBXO5 3 GO:0030323 respiratory tube development 11/1036 176/18670 0.3867 0.7967 0.7035 TGFBR2/ADAMTS2/LIPA/TNF/HSPB11/LHX3/MAPK3/LIF/HEG1/FGF18/RCN3 11 GO:0001919 regulation of receptor recycling 2/1036 24/18670 0.3878 0.7967 0.7035 OPTN/TRAT1 2 GO:0003181 atrioventricular valve morphogenesis 2/1036 24/18670 0.3878 0.7967 0.7035 TGFBR2/ACVR1 2 GO:0003272 endocardial cushion formation 2/1036 24/18670 0.3878 0.7967 0.7035 TGFBR2/ACVR1 2 GO:0006862 nucleotide transport 2/1036 24/18670 0.3878 0.7967 0.7035 SLC25A32/SLC25A5 2 GO:0007097 nuclear migration 2/1036 24/18670 0.3878 0.7967 0.7035 PCM1/NTN1 2 GO:0007141 male meiosis I 2/1036 24/18670 0.3878 0.7967 0.7035 MYBL1/UBB 2 GO:0008535 respiratory chain complex IV assembly 2/1036 24/18670 0.3878 0.7967 0.7035 FASTKD3/OXA1L 2 GO:0009218 pyrimidine ribonucleotide metabolic process 2/1036 24/18670 0.3878 0.7967 0.7035 CMPK1/UCKL1 2 GO:0010288 response to lead ion 2/1036 24/18670 0.3878 0.7967 0.7035 CAT/QDPR 2 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 2/1036 24/18670 0.3878 0.7967 0.7035 CBLB/LRP1 2 GO:0014850 response to muscle activity 2/1036 24/18670 0.3878 0.7967 0.7035 ADSL/TOMM20 2 GO:0021871 forebrain regionalization 2/1036 24/18670 0.3878 0.7967 0.7035 TRA2B/PGAP1 2 GO:0021904 dorsal/ventral neural tube patterning 2/1036 24/18670 0.3878 0.7967 0.7035 FKBP8/PRKACB 2 GO:0032897 negative regulation of viral transcription 2/1036 24/18670 0.3878 0.7967 0.7035 CCL5/ZFP36 2 GO:0035588 G protein-coupled purinergic receptor signaling pathway 2/1036 24/18670 0.3878 0.7967 0.7035 GPR171/P2RY10 2 GO:0036315 cellular response to sterol 2/1036 24/18670 0.3878 0.7967 0.7035 RORA/INSIG1 2 GO:0042104 positive regulation of activated T cell proliferation 2/1036 24/18670 0.3878 0.7967 0.7035 IL12B/IL23A 2 GO:0042430 indole-containing compound metabolic process 2/1036 24/18670 0.3878 0.7967 0.7035 KMO/KYNU 2 GO:0042537 benzene-containing compound metabolic process 2/1036 24/18670 0.3878 0.7967 0.7035 KMO/KYNU 2 GO:0045606 positive regulation of epidermal cell differentiation 2/1036 24/18670 0.3878 0.7967 0.7035 PRKCH/NCOA3 2 GO:0046639 negative regulation of alpha-beta T cell differentiation 2/1036 24/18670 0.3878 0.7967 0.7035 ANXA1/TBX21 2 GO:0046697 decidualization 2/1036 24/18670 0.3878 0.7967 0.7035 MAPK3/LIF 2 GO:0051220 cytoplasmic sequestering of protein 2/1036 24/18670 0.3878 0.7967 0.7035 DBN1/PSMD10 2 GO:0071677 positive regulation of mononuclear cell migration 2/1036 24/18670 0.3878 0.7967 0.7035 CCL5/TNF 2 GO:1902914 regulation of protein polyubiquitination 2/1036 24/18670 0.3878 0.7967 0.7035 PTPN22/TRIM44 2 GO:1903649 regulation of cytoplasmic transport 2/1036 24/18670 0.3878 0.7967 0.7035 MAP2/MAPK3 2 GO:2000178 negative regulation of neural precursor cell proliferation 2/1036 24/18670 0.3878 0.7967 0.7035 BTG2/SPINT1 2 GO:1903531 negative regulation of secretion by cell 13/1036 211/18670 0.3895 0.7984 0.705 ABAT/IL1B/CHGA/CRY1/TNF/PTPN22/ANXA1/RSAD2/TRH/LIF/PTGER4/TLR6/BCR 13 GO:0090068 positive regulation of cell cycle process 18/1036 298/18670 0.3897 0.7984 0.705 PCNA/IL1A/IL1B/SFPQ/AURKC/CDC25B/ANAPC5/BTG2/ANKRD17/ANXA1/PHB2/SMARCD3/NPM1/NDC80/DYRK3/FBXO5/ATRX/CDC7 18 GO:0038094 Fc-gamma receptor signaling pathway 9/1036 142/18670 0.39 0.7984 0.705 CD247/NCK1/FYN/WAS/CYFIP2/PIK3CA/MAPK3/ELMO2/PIK3R1 9 GO:0072006 nephron development 9/1036 142/18670 0.39 0.7984 0.705 MYC/NUP107/MAGED1/SULF1/NUP85/LIF/NUP160/SIX2/ACAT1 9 GO:0016042 lipid catabolic process 20/1036 333/18670 0.3901 0.7984 0.705 DDHD2/ABCD3/IL1B/LIPA/CRTC3/PNPLA6/TNF/ACADM/LRP1/LIPE/ETFA/PLCB3/SCP2/AKR1C3/PRDX6/GDPD3/PLA2G3/CYP4A11/ACAT1/CYP4F12 20 GO:0048193 Golgi vesicle transport 22/1036 368/18670 0.3902 0.7984 0.705 OPTN/DDHD2/KIF2A/COG5/CTSC/INSIG1/DYNLL1/SCFD1/KIFAP3/ERGIC2/CCDC91/ANXA13/RANGRF/VPS51/C16orf70/EHD3/ACSL3/DCTN6/PGAP1/GOSR1/SEC24A/TMED2 22 GO:0014888 striated muscle adaptation 4/1036 57/18670 0.3903 0.7984 0.705 ATP2A2/TNNI1/HDAC4/IL15 4 GO:0018208 peptidyl-proline modification 4/1036 57/18670 0.3903 0.7984 0.705 FKBP8/FKBP11/FKBP3/FKBP10 4 GO:0033344 cholesterol efflux 4/1036 57/18670 0.3903 0.7984 0.705 CETP/NPC1/LRP1/PON1 4 GO:0051055 negative regulation of lipid biosynthetic process 4/1036 57/18670 0.3903 0.7984 0.705 NFKB1/INSIG1/AKR1C3/SOD1 4 GO:0060760 positive regulation of response to cytokine stimulus 4/1036 57/18670 0.3903 0.7984 0.705 TRIM44/CXCR4/TXK/AGPAT2 4 GO:1902115 regulation of organelle assembly 12/1036 194/18670 0.3917 0.7996 0.7061 ATMIN/DYNLL1/TRIM37/SCFD1/VDAC3/TNF/NPM1/CEP76/ZMYND10/RNF4/ATG5/FEZ1 12 GO:0046916 cellular transition metal ion homeostasis 7/1036 108/18670 0.3925 0.7996 0.7061 MYC/SKP1/LCK/SLC30A9/CUL1/SOD1/SLC39A6 7 GO:0005977 glycogen metabolic process 5/1036 74/18670 0.3925 0.7996 0.7061 DYRK2/PASK/UGP2/PPP1CC/PHKG1 5 GO:0006081 cellular aldehyde metabolic process 5/1036 74/18670 0.3925 0.7996 0.7061 DERA/GLO1/AKR7A2/AKR1C3/ALDH3B1 5 GO:0032418 lysosome localization 5/1036 74/18670 0.3925 0.7996 0.7061 CHGA/RASGRP1/SPHK2/TMEM106B/PLA2G3 5 GO:0032507 maintenance of protein location in cell 5/1036 74/18670 0.3925 0.7996 0.7061 SKP1/INSIG1/SUPT7L/SYNE1/DBN1 5 GO:0043507 positive regulation of JUN kinase activity 5/1036 74/18670 0.3925 0.7996 0.7061 TNF/MAP4K5/MAP4K2/TLR6/DAXX 5 GO:0048199 vesicle targeting, to, from or within Golgi 5/1036 74/18670 0.3925 0.7996 0.7061 CTSC/SCFD1/GOSR1/SEC24A/TMED2 5 GO:0050710 negative regulation of cytokine secretion 5/1036 74/18670 0.3925 0.7996 0.7061 TNF/PTPN22/ANXA1/PTGER4/TLR6 5 GO:1900006 positive regulation of dendrite development 5/1036 74/18670 0.3925 0.7996 0.7061 CAPRIN2/DNM1L/TMEM106B/DBN1/CAPRIN1 5 GO:1901616 organic hydroxy compound catabolic process 5/1036 74/18670 0.3925 0.7996 0.7061 NTSR1/AKR1C3/ALDH3B1/CYP4A11/CYP4F12 5 GO:0006888 ER to Golgi vesicle-mediated transport 13/1036 212/18670 0.396 0.8066 0.7122 DDHD2/COG5/CTSC/INSIG1/DYNLL1/SCFD1/ERGIC2/RANGRF/DCTN6/PGAP1/GOSR1/SEC24A/TMED2 13 GO:0035296 regulation of tube diameter 9/1036 143/18670 0.398 0.8092 0.7146 CD38/P2RX1/GCLC/CHGA/HRH2/AVPR1B/PIK3C2A/SOD1/ATG5 9 GO:0048813 dendrite morphogenesis 9/1036 143/18670 0.398 0.8092 0.7146 FYN/CAPRIN2/MAP2/DNM1L/TMEM106B/STK11/DBN1/CAPRIN1/DSCAM 9 GO:0050880 regulation of blood vessel size 9/1036 143/18670 0.398 0.8092 0.7146 CD38/P2RX1/GCLC/CHGA/HRH2/AVPR1B/PIK3C2A/SOD1/ATG5 9 GO:0097746 regulation of blood vessel diameter 9/1036 143/18670 0.398 0.8092 0.7146 CD38/P2RX1/GCLC/CHGA/HRH2/AVPR1B/PIK3C2A/SOD1/ATG5 9 GO:0007520 myoblast fusion 3/1036 41/18670 0.3995 0.8092 0.7146 EHD2/KCNH1/CD9 3 GO:0035136 forelimb morphogenesis 3/1036 41/18670 0.3995 0.8092 0.7146 RECK/ZBTB16/ATRX 3 GO:0042572 retinol metabolic process 3/1036 41/18670 0.3995 0.8092 0.7146 AKR1B1/AKR1C3/RDH16 3 GO:0043403 skeletal muscle tissue regeneration 3/1036 41/18670 0.3995 0.8092 0.7146 TGFBR2/ANXA1/CD9 3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 3/1036 41/18670 0.3995 0.8092 0.7146 PCNA/ATRX/DONSON 3 GO:0045616 regulation of keratinocyte differentiation 3/1036 41/18670 0.3995 0.8092 0.7146 PRKCH/ZFP36/NCOA3 3 GO:0060119 inner ear receptor cell development 3/1036 41/18670 0.3995 0.8092 0.7146 GABRB2/SOD1/FZD2 3 GO:0061028 establishment of endothelial barrier 3/1036 41/18670 0.3995 0.8092 0.7146 IL1B/PPP1R16B/TNF 3 GO:0098927 vesicle-mediated transport between endosomal compartments 3/1036 41/18670 0.3995 0.8092 0.7146 STX8/EMP2/MAPK3 3 GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 3/1036 41/18670 0.3995 0.8092 0.7146 HDAC4/SPI1/LILRB4 3 GO:1904018 positive regulation of vasculature development 14/1036 230/18670 0.3999 0.8093 0.7146 IL1A/CCR3/TGFBR2/IL1B/PPP1R16B/RRAS/HSPB6/CXCR4/ANXA1/TLR3/XBP1/PIK3C2A/CCL11/FGF18 14 GO:2001234 negative regulation of apoptotic signaling pathway 14/1036 230/18670 0.3999 0.8093 0.7146 IL1A/IL1B/ITGA6/SLC25A5/GCLC/ACVR1/FYN/TNF/SIAH2/CSNK2A2/XBP1/PSMD10/ZMYND11/SLC35F6 14 GO:0045667 regulation of osteoblast differentiation 8/1036 126/18670 0.3999 0.8093 0.7146 IL6/GNAS/ACVR1/TNF/BMPR1B/HDAC4/PDLIM7/FBXO5 8 GO:0019319 hexose biosynthetic process 6/1036 92/18670 0.403 0.8137 0.7185 MDH1/PGK1/CRY1/ATF3/CLK2/AKR1B1 6 GO:0019229 regulation of vasoconstriction 4/1036 58/18670 0.403 0.8137 0.7185 CD38/P2RX1/HRH2/AVPR1B 4 GO:0060997 dendritic spine morphogenesis 4/1036 58/18670 0.403 0.8137 0.7185 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/1036 58/18670 0.403 0.8137 0.7185 GZMB/CSNK2A2/YWHAQ/PMAIP1 4 GO:0006302 double-strand break repair 15/1036 248/18670 0.4033 0.8137 0.7185 PARP1/SFPQ/PSMD14/WAS/DDX1/MSH2/PIAS4/SETX/RPA1/XRCC2/HERC2/CDC7/MCM6/ZBTB7A/POLQ 15 GO:0051258 protein polymerization 17/1036 283/18670 0.4035 0.8137 0.7185 RANBP9/NCK1/TUBGCP2/RASA1/ADD3/WAS/PSTPIP1/MAP2/DNM1L/RANGRF/CCL11/CLASP1/DBN1/FBXO5/DYRK1A/HAX1/TERF1 17 GO:0002200 somatic diversification of immune receptors 5/1036 75/18670 0.4036 0.8137 0.7185 TNFSF13/MSH2/TBX21/BCL11B/POLQ 5 GO:0006073 cellular glucan metabolic process 5/1036 75/18670 0.4036 0.8137 0.7185 DYRK2/PASK/UGP2/PPP1CC/PHKG1 5 GO:0015914 phospholipid transport 5/1036 75/18670 0.4036 0.8137 0.7185 ABCB1/CETP/ATP8A1/STARD7/SCP2 5 GO:0044042 glucan metabolic process 5/1036 75/18670 0.4036 0.8137 0.7185 DYRK2/PASK/UGP2/PPP1CC/PHKG1 5 GO:0035150 regulation of tube size 9/1036 144/18670 0.406 0.8153 0.7199 CD38/P2RX1/GCLC/CHGA/HRH2/AVPR1B/PIK3C2A/SOD1/ATG5 9 GO:0002053 positive regulation of mesenchymal cell proliferation 2/1036 25/18670 0.4076 0.8153 0.7199 MYC/TGFBR2 2 GO:0007026 negative regulation of microtubule depolymerization 2/1036 25/18670 0.4076 0.8153 0.7199 CKAP2/CLASP1 2 GO:0007214 gamma-aminobutyric acid signaling pathway 2/1036 25/18670 0.4076 0.8153 0.7199 PLCL1/GABRB2 2 GO:0021680 cerebellar Purkinje cell layer development 2/1036 25/18670 0.4076 0.8153 0.7199 RORA/HERC1 2 GO:0030325 adrenal gland development 2/1036 25/18670 0.4076 0.8153 0.7199 ARID5B/CITED2 2 GO:0032509 endosome transport via multivesicular body sorting pathway 2/1036 25/18670 0.4076 0.8153 0.7199 LEPROTL1/VPS37B 2 GO:0032616 interleukin-13 production 2/1036 25/18670 0.4076 0.8153 0.7199 RARA/SPHK2 2 GO:0033522 histone H2A ubiquitination 2/1036 25/18670 0.4076 0.8153 0.7199 SKP1/TRIM37 2 GO:0045332 phospholipid translocation 2/1036 25/18670 0.4076 0.8153 0.7199 ABCB1/ATP8A1 2 GO:0060330 regulation of response to interferon-gamma 2/1036 25/18670 0.4076 0.8153 0.7199 IFNG/TXK 2 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 2/1036 25/18670 0.4076 0.8153 0.7199 IFNG/TXK 2 GO:0060444 branching involved in mammary gland duct morphogenesis 2/1036 25/18670 0.4076 0.8153 0.7199 PHB2/CCL11 2 GO:0061217 regulation of mesonephros development 2/1036 25/18670 0.4076 0.8153 0.7199 MAGED1/SIX2 2 GO:0072202 cell differentiation involved in metanephros development 2/1036 25/18670 0.4076 0.8153 0.7199 LIF/SIX2 2 GO:0072273 metanephric nephron morphogenesis 2/1036 25/18670 0.4076 0.8153 0.7199 LIF/SIX2 2 GO:0090025 regulation of monocyte chemotaxis 2/1036 25/18670 0.4076 0.8153 0.7199 CCL5/SLAMF8 2 GO:0097186 amelogenesis 2/1036 25/18670 0.4076 0.8153 0.7199 ITGA6/ITGB4 2 GO:1903859 regulation of dendrite extension 2/1036 25/18670 0.4076 0.8153 0.7199 CPNE6/CXCR4 2 GO:2000353 positive regulation of endothelial cell apoptotic process 2/1036 25/18670 0.4076 0.8153 0.7199 ITGA4/AKR1C3 2 GO:2000679 positive regulation of transcription regulatory region DNA binding 2/1036 25/18670 0.4076 0.8153 0.7199 PARP1/IFNG 2 GO:0031589 cell-substrate adhesion 21/1036 354/18670 0.408 0.8156 0.7202 CD96/C1QBP/MADCAM1/ITGA4/ITGA6/RASA1/ITGA7/LRP1/PRKX/ARHGEF7/EMP2/PARVA/ACTN1/CLASP1/ITGB4/CCL25/ADAM15/CD3E/BCAM/PIK3R1/BCR 21 GO:0008361 regulation of cell size 11/1036 179/18670 0.4082 0.8158 0.7204 ARHGAP4/SLC12A5/CLNS1A/MAP2/LRP1/SEMA4G/SEMA3G/DBN1/DSCAM/NTN1/ADNP 11 GO:0045732 positive regulation of protein catabolic process 13/1036 214/18670 0.4092 0.8159 0.7205 IFNG/RCHY1/IL1B/DACT1/CTSC/PSMC2/GCLC/TNF/RBX1/TRIB2/LRP1/EDEM1/PSMD10 13 GO:0031960 response to corticosteroid 10/1036 162/18670 0.4111 0.8159 0.7205 PCNA/PARP1/IL6/HSD11B2/ZFP36/TNF/ANXA1/TRH/AKR1C3/GHRHR 10 GO:0007589 body fluid secretion 6/1036 93/18670 0.413 0.8159 0.7205 XBP1/USF2/CSN2/GHRHR/APRT/ATG5 6 GO:0032092 positive regulation of protein binding 6/1036 93/18670 0.413 0.8159 0.7205 DACT1/DERL1/PLCL1/CAPRIN2/LRP1/RPL11 6 GO:1901184 regulation of ERBB signaling pathway 6/1036 93/18670 0.413 0.8159 0.7205 SOS1/CBLB/ARHGEF7/EPS15L1/DOK1/RNF115 6 GO:0002431 Fc receptor mediated stimulatory signaling pathway 9/1036 145/18670 0.414 0.8159 0.7205 CD247/NCK1/FYN/WAS/CYFIP2/PIK3CA/MAPK3/ELMO2/PIK3R1 9 GO:0006865 amino acid transport 9/1036 145/18670 0.414 0.8159 0.7205 ABAT/KMO/SLC38A1/NTSR1/SV2A/SLC7A5/TRH/SLC38A2/SLC1A3 9 GO:0006284 base-excision repair 3/1036 42/18670 0.4146 0.8159 0.7205 PCNA/RPA1/POLQ 3 GO:0010470 regulation of gastrulation 3/1036 42/18670 0.4146 0.8159 0.7205 POGLUT1/MBP/CLASP1 3 GO:0015701 bicarbonate transport 3/1036 42/18670 0.4146 0.8159 0.7205 CA7/RHAG/CA9 3 GO:0017145 stem cell division 3/1036 42/18670 0.4146 0.8159 0.7205 LBH/NCOA3/ZBTB16 3 GO:0031057 negative regulation of histone modification 3/1036 42/18670 0.4146 0.8159 0.7205 SPHK2/SPI1/ATG5 3 GO:0031641 regulation of myelination 3/1036 42/18670 0.4146 0.8159 0.7205 CTSC/RARA/CST7 3 GO:0042181 ketone biosynthetic process 3/1036 42/18670 0.4146 0.8159 0.7205 PDSS1/AKR1C3/COQ9 3 GO:0097028 dendritic cell differentiation 3/1036 42/18670 0.4146 0.8159 0.7205 TGFBR2/TRPM2/SPI1 3 GO:1901031 regulation of response to reactive oxygen species 3/1036 42/18670 0.4146 0.8159 0.7205 SESN1/TNF/PDE8A 3 GO:0042310 vasoconstriction 5/1036 76/18670 0.4148 0.8159 0.7205 CD38/P2RX1/HRH2/AVPR1B/PIK3C2A 5 GO:0045454 cell redox homeostasis 5/1036 76/18670 0.4148 0.8159 0.7205 DLD/TMX1/GCLC/NNT/PRDX6 5 GO:0061045 negative regulation of wound healing 5/1036 76/18670 0.4148 0.8159 0.7205 ABAT/WFDC1/F12/CLASP1/CD9 5 GO:0001885 endothelial cell development 4/1036 59/18670 0.4157 0.8159 0.7205 IL1B/PPP1R16B/TNF/HEG1 4 GO:0010518 positive regulation of phospholipase activity 4/1036 59/18670 0.4157 0.8159 0.7205 CCL5/TXK/ITK/AVPR1B 4 GO:0045071 negative regulation of viral genome replication 4/1036 59/18670 0.4157 0.8159 0.7205 CCL5/TNF/RSAD2/APOBEC3G 4 GO:0002576 platelet degranulation 8/1036 128/18670 0.417 0.8159 0.7205 CDC37L1/P2RX1/ACTN1/ABCC4/CD9/ENDOD1/SOD1/OLA1 8 GO:0051291 protein heterooligomerization 8/1036 128/18670 0.417 0.8159 0.7205 PDSS1/P2RX1/BIRC3/CHRNA2/NUDT21/GLRA1/MCCC1/P2RX6 8 GO:0006959 humoral immune response 21/1036 356/18670 0.4182 0.8159 0.7205 CXCL11/IL6/SH2D1A/IFNG/IL1B/C1QBP/POU2F2/LYZ/HMGN2/HLA-DQB1/CHGA/TNF/C8B/CD83/ELANE/GPR183/FCN1/CD5L/CTSG/PGLYRP4/TRBC1 21 GO:0060541 respiratory system development 12/1036 198/18670 0.4191 0.8159 0.7205 TGFBR2/ADAMTS2/LIPA/TNF/HSPB11/LHX3/RARA/MAPK3/LIF/HEG1/FGF18/RCN3 12 GO:0045834 positive regulation of lipid metabolic process 9/1036 146/18670 0.422 0.8159 0.7205 IFNG/ATG14/IL1B/LDLRAP1/TNF/ANXA1/SPHK2/DGKZ/ACSL3 9 GO:0061337 cardiac conduction 9/1036 146/18670 0.422 0.8159 0.7205 ATP2A2/SCN10A/SLC8A2/ATP1B1/CACNB4/RANGRF/ATP2B2/EHD3/KCNQ1 9 GO:0032869 cellular response to insulin stimulus 13/1036 216/18670 0.4223 0.8159 0.7205 PARP1/SOS1/IL1B/NCK1/PRKCQ/GCLC/XBP1/TBC1D4/PIK3CA/PIK3C2A/GHRHR/APRT/PIK3R1 13 GO:0060562 epithelial tube morphogenesis 19/1036 322/18670 0.4248 0.8159 0.7205 MYC/TGFBR2/PRKACB/MAGED1/ACVR1/TNF/CXCR4/RPS7/PLXNB2/PHB2/PRKX/SPINT1/RARA/RBM15/CCL11/NTN1/SIX2/FZD2/TMED2 19 GO:0051851 modification by host of symbiont morphology or physiology 5/1036 77/18670 0.4259 0.8159 0.7205 CCL5/PTX3/RAB9A/ELANE/CTSG 5 GO:0001556 oocyte maturation 2/1036 26/18670 0.4272 0.8159 0.7205 CDC25B/FBXO5 2 GO:0001835 blastocyst hatching 2/1036 26/18670 0.4272 0.8159 0.7205 CTR9/LPAR6 2 GO:0003171 atrioventricular valve development 2/1036 26/18670 0.4272 0.8159 0.7205 TGFBR2/ACVR1 2 GO:0006516 glycoprotein catabolic process 2/1036 26/18670 0.4272 0.8159 0.7205 SGSH/EDEM1 2 GO:0006700 C21-steroid hormone biosynthetic process 2/1036 26/18670 0.4272 0.8159 0.7205 FDX1/AKR1B1 2 GO:0006779 porphyrin-containing compound biosynthetic process 2/1036 26/18670 0.4272 0.8159 0.7205 SUCLA2/RSAD1 2 GO:0030194 positive regulation of blood coagulation 2/1036 26/18670 0.4272 0.8159 0.7205 ENPP4/F12 2 GO:0032957 inositol trisphosphate metabolic process 2/1036 26/18670 0.4272 0.8159 0.7205 PLCL1/PLCB3 2 GO:0034204 lipid translocation 2/1036 26/18670 0.4272 0.8159 0.7205 ABCB1/ATP8A1 2 GO:0035188 hatching 2/1036 26/18670 0.4272 0.8159 0.7205 CTR9/LPAR6 2 GO:0043090 amino acid import 2/1036 26/18670 0.4272 0.8159 0.7205 NTSR1/SLC1A3 2 GO:0045992 negative regulation of embryonic development 2/1036 26/18670 0.4272 0.8159 0.7205 PRKACB/SULF1 2 GO:0048843 negative regulation of axon extension involved in axon guidance 2/1036 26/18670 0.4272 0.8159 0.7205 SEMA4G/SEMA3G 2 GO:0051497 negative regulation of stress fiber assembly 2/1036 26/18670 0.4272 0.8159 0.7205 WAS/CLASP1 2 GO:0051788 response to misfolded protein 2/1036 26/18670 0.4272 0.8159 0.7205 DERL1/F12 2 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/1036 26/18670 0.4272 0.8159 0.7205 CLIC2/JPH3 2 GO:0071377 cellular response to glucagon stimulus 2/1036 26/18670 0.4272 0.8159 0.7205 PRKACB/PRKAR2B 2 GO:0071684 organism emergence from protective structure 2/1036 26/18670 0.4272 0.8159 0.7205 CTR9/LPAR6 2 GO:1900048 positive regulation of hemostasis 2/1036 26/18670 0.4272 0.8159 0.7205 ENPP4/F12 2 GO:1900120 regulation of receptor binding 2/1036 26/18670 0.4272 0.8159 0.7205 PLCL1/ADAM15 2 GO:0042267 natural killer cell mediated cytotoxicity 4/1036 60/18670 0.4283 0.8159 0.7205 SH2D1A/IL12B/GZMB/RASGRP1 4 GO:0000041 transition metal ion transport 7/1036 112/18670 0.4292 0.8159 0.7205 IFNG/TRPM2/CUTC/SLC30A9/MCOLN1/TCN2/SLC39A6 7 GO:0015918 sterol transport 7/1036 112/18670 0.4292 0.8159 0.7205 NFKB1/CETP/LDLRAP1/NPC1/LRP1/SCP2/PON1 7 GO:1903510 mucopolysaccharide metabolic process 7/1036 112/18670 0.4292 0.8159 0.7205 NFKB1/SLC35D1/IL1B/CHST12/CHPF2/IL15/B3GNT2 7 GO:0006692 prostanoid metabolic process 3/1036 43/18670 0.4296 0.8159 0.7205 IL1B/ANXA1/AKR1C3 3 GO:0006693 prostaglandin metabolic process 3/1036 43/18670 0.4296 0.8159 0.7205 IL1B/ANXA1/AKR1C3 3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 3/1036 43/18670 0.4296 0.8159 0.7205 PARP1/SFPQ/SOD1 3 GO:0010824 regulation of centrosome duplication 3/1036 43/18670 0.4296 0.8159 0.7205 TRIM37/NPM1/CEP76 3 GO:0010863 positive regulation of phospholipase C activity 3/1036 43/18670 0.4296 0.8159 0.7205 TXK/ITK/AVPR1B 3 GO:0021762 substantia nigra development 3/1036 43/18670 0.4296 0.8159 0.7205 DYNLL1/YWHAQ/MBP 3 GO:0030866 cortical actin cytoskeleton organization 3/1036 43/18670 0.4296 0.8159 0.7205 TNF/WAS/EHD2 3 GO:0032365 intracellular lipid transport 3/1036 43/18670 0.4296 0.8159 0.7205 LDLRAP1/NPC1/SCP2 3 GO:0032881 regulation of polysaccharide metabolic process 3/1036 43/18670 0.4296 0.8159 0.7205 DYRK2/NFKB1/PASK 3 GO:0033173 calcineurin-NFAT signaling cascade 3/1036 43/18670 0.4296 0.8159 0.7205 DYRK2/ERBB3/TNF 3 GO:0045687 positive regulation of glial cell differentiation 3/1036 43/18670 0.4296 0.8159 0.7205 CXCR4/SPINT1/LIF 3 GO:0086004 regulation of cardiac muscle cell contraction 3/1036 43/18670 0.4296 0.8159 0.7205 ATP2A2/PDE4B/RANGRF 3 GO:0061138 morphogenesis of a branching epithelium 11/1036 182/18670 0.4297 0.8159 0.7205 MYC/TGFBR2/MAGED1/ACVR1/TNF/PHB2/SPINT1/SULF1/RBM15/CCL11/SIX2 11 GO:0010212 response to ionizing radiation 9/1036 147/18670 0.43 0.8159 0.7205 PARP1/MYC/TOPBP1/ANXA1/MSH2/CLK2/ATR/STK11/XRCC2 9 GO:0051952 regulation of amine transport 6/1036 95/18670 0.433 0.8159 0.7205 ABAT/KMO/CHGA/NTSR1/SV2A/TRH 6 GO:0051648 vesicle localization 18/1036 306/18670 0.4339 0.8159 0.7205 ITGA4/CTSC/ATP2A2/TMEM230/P2RX1/SCFD1/SV2A/KIFAP3/MAP2/RASGRP1/DNM1L/FYCO1/CHRM2/MAP4K2/CLASP1/GOSR1/SEC24A/TMED2 18 GO:0006644 phospholipid metabolic process 25/1036 430/18670 0.4342 0.8159 0.7205 DDHD2/ATG14/IDI1/CHRM5/CETP/CPNE6/PNPLA6/CSNK2A2/STARD7/CPNE3/PIK3CA/GPD1L/CCKBR/SPHK2/DGKZ/PON1/AGPAT2/PIK3C2A/PRDX6/AGK/ACSL3/GDPD3/PLA2G3/PGAP1/PIK3R1 25 GO:0000012 single strand break repair 1/1036 10/18670 0.4351 0.8159 0.7205 PARP1 1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA 1/1036 10/18670 0.4351 0.8159 0.7205 DCP1A 1 GO:0000338 protein deneddylation 1/1036 10/18670 0.4351 0.8159 0.7205 COPS4 1 GO:0001820 serotonin secretion 1/1036 10/18670 0.4351 0.8159 0.7205 P2RX1 1 GO:0003183 mitral valve morphogenesis 1/1036 10/18670 0.4351 0.8159 0.7205 ACVR1 1 GO:0003211 cardiac ventricle formation 1/1036 10/18670 0.4351 0.8159 0.7205 SMARCD3 1 GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 SPHK2 1 GO:0006188 IMP biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 ADSL 1 GO:0006307 DNA dealkylation involved in DNA repair 1/1036 10/18670 0.4351 0.8159 0.7205 ASCC3 1 GO:0006971 hypotonic response 1/1036 10/18670 0.4351 0.8159 0.7205 SLC12A5 1 GO:0007028 cytoplasm organization 1/1036 10/18670 0.4351 0.8159 0.7205 SOS1 1 GO:0007084 mitotic nuclear envelope reassembly 1/1036 10/18670 0.4351 0.8159 0.7205 VRK1 1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 GNAS 1 GO:0007220 Notch receptor processing 1/1036 10/18670 0.4351 0.8159 0.7205 APH1B 1 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 DCK 1 GO:0010918 positive regulation of mitochondrial membrane potential 1/1036 10/18670 0.4351 0.8159 0.7205 NNT 1 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation 1/1036 10/18670 0.4351 0.8159 0.7205 HDAC4 1 GO:0014894 response to denervation involved in regulation of muscle adaptation 1/1036 10/18670 0.4351 0.8159 0.7205 HDAC4 1 GO:0015801 aromatic amino acid transport 1/1036 10/18670 0.4351 0.8159 0.7205 SLC7A5 1 GO:0016102 diterpenoid biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 AKR1C3 1 GO:0018065 protein-cofactor linkage 1/1036 10/18670 0.4351 0.8159 0.7205 LIPT1 1 GO:0018242 protein O-linked glycosylation via serine 1/1036 10/18670 0.4351 0.8159 0.7205 POGLUT1 1 GO:0018342 protein prenylation 1/1036 10/18670 0.4351 0.8159 0.7205 FNTA 1 GO:0021877 forebrain neuron fate commitment 1/1036 10/18670 0.4351 0.8159 0.7205 BCL11B 1 GO:0021924 cell proliferation in external granule layer 1/1036 10/18670 0.4351 0.8159 0.7205 RORA 1 GO:0021930 cerebellar granule cell precursor proliferation 1/1036 10/18670 0.4351 0.8159 0.7205 RORA 1 GO:0030311 poly-N-acetyllactosamine biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 B3GNT2 1 GO:0031340 positive regulation of vesicle fusion 1/1036 10/18670 0.4351 0.8159 0.7205 ANXA1 1 GO:0032308 positive regulation of prostaglandin secretion 1/1036 10/18670 0.4351 0.8159 0.7205 IL1B 1 GO:0032328 alanine transport 1/1036 10/18670 0.4351 0.8159 0.7205 SLC38A2 1 GO:0032353 negative regulation of hormone biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 NFKB1 1 GO:0032525 somite rostral/caudal axis specification 1/1036 10/18670 0.4351 0.8159 0.7205 TMED2 1 GO:0032836 glomerular basement membrane development 1/1036 10/18670 0.4351 0.8159 0.7205 SULF1 1 GO:0032875 regulation of DNA endoreduplication 1/1036 10/18670 0.4351 0.8159 0.7205 FBXO5 1 GO:0032926 negative regulation of activin receptor signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 ACVR1 1 GO:0033182 regulation of histone ubiquitination 1/1036 10/18670 0.4351 0.8159 0.7205 CTR9 1 GO:0034135 regulation of toll-like receptor 2 signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 TLR6 1 GO:0034350 regulation of glial cell apoptotic process 1/1036 10/18670 0.4351 0.8159 0.7205 PRKCH 1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1/1036 10/18670 0.4351 0.8159 0.7205 EXOSC8 1 GO:0034454 microtubule anchoring at centrosome 1/1036 10/18670 0.4351 0.8159 0.7205 PCM1 1 GO:0035376 sterol import 1/1036 10/18670 0.4351 0.8159 0.7205 LRP1 1 GO:0035768 endothelial cell chemotaxis to fibroblast growth factor 1/1036 10/18670 0.4351 0.8159 0.7205 FGF18 1 GO:0035865 cellular response to potassium ion 1/1036 10/18670 0.4351 0.8159 0.7205 SOD1 1 GO:0036500 ATF6-mediated unfolded protein response 1/1036 10/18670 0.4351 0.8159 0.7205 XBP1 1 GO:0044539 long-chain fatty acid import 1/1036 10/18670 0.4351 0.8159 0.7205 ACSL3 1 GO:0044557 relaxation of smooth muscle 1/1036 10/18670 0.4351 0.8159 0.7205 SOD1 1 GO:0044803 multi-organism membrane organization 1/1036 10/18670 0.4351 0.8159 0.7205 CXCR4 1 GO:0045625 regulation of T-helper 1 cell differentiation 1/1036 10/18670 0.4351 0.8159 0.7205 ANXA1 1 GO:0045713 low-density lipoprotein particle receptor biosynthetic process 1/1036 10/18670 0.4351 0.8159 0.7205 SEC24A 1 GO:0045876 positive regulation of sister chromatid cohesion 1/1036 10/18670 0.4351 0.8159 0.7205 SFPQ 1 GO:0046498 S-adenosylhomocysteine metabolic process 1/1036 10/18670 0.4351 0.8159 0.7205 AHCY 1 GO:0050861 positive regulation of B cell receptor signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 PRKCH 1 GO:0051255 spindle midzone assembly 1/1036 10/18670 0.4351 0.8159 0.7205 AURKC 1 GO:0051901 positive regulation of mitochondrial depolarization 1/1036 10/18670 0.4351 0.8159 0.7205 PARP1 1 GO:0052646 alditol phosphate metabolic process 1/1036 10/18670 0.4351 0.8159 0.7205 GPD1L 1 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization 1/1036 10/18670 0.4351 0.8159 0.7205 SCN10A 1 GO:0060513 prostatic bud formation 1/1036 10/18670 0.4351 0.8159 0.7205 SULF1 1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development 1/1036 10/18670 0.4351 0.8159 0.7205 STK11 1 GO:0060923 cardiac muscle cell fate commitment 1/1036 10/18670 0.4351 0.8159 0.7205 ACVR1 1 GO:0061635 regulation of protein complex stability 1/1036 10/18670 0.4351 0.8159 0.7205 ATG14 1 GO:0070099 regulation of chemokine-mediated signaling pathway 1/1036 10/18670 0.4351 0.8159 0.7205 CCL5 1 GO:0070391 response to lipoteichoic acid 1/1036 10/18670 0.4351 0.8159 0.7205 LBP 1 GO:0070472 regulation of uterine smooth muscle contraction 1/1036 10/18670 0.4351 0.8159 0.7205 ABAT 1 GO:0070508 cholesterol import 1/1036 10/18670 0.4351 0.8159 0.7205 LRP1 1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 1/1036 10/18670 0.4351 0.8159 0.7205 GTF2H3 1 GO:0071223 cellular response to lipoteichoic acid 1/1036 10/18670 0.4351 0.8159 0.7205 LBP 1 GO:0071233 cellular response to leucine 1/1036 10/18670 0.4351 0.8159 0.7205 SESN1 1 GO:0071501 cellular response to sterol depletion 1/1036 10/18670 0.4351 0.8159 0.7205 INSIG1 1 GO:0071670 smooth muscle cell chemotaxis 1/1036 10/18670 0.4351 0.8159 0.7205 PARVA 1 GO:0072203 cell proliferation involved in metanephros development 1/1036 10/18670 0.4351 0.8159 0.7205 MYC 1 GO:0090037 positive regulation of protein kinase C signaling 1/1036 10/18670 0.4351 0.8159 0.7205 SPHK2 1 GO:0090205 positive regulation of cholesterol metabolic process 1/1036 10/18670 0.4351 0.8159 0.7205 LDLRAP1 1 GO:0097050 type B pancreatic cell apoptotic process 1/1036 10/18670 0.4351 0.8159 0.7205 IL6 1 GO:0097278 complement-dependent cytotoxicity 1/1036 10/18670 0.4351 0.8159 0.7205 CD5L 1 GO:0097354 prenylation 1/1036 10/18670 0.4351 0.8159 0.7205 FNTA 1 GO:0098722 asymmetric stem cell division 1/1036 10/18670 0.4351 0.8159 0.7205 ZBTB16 1 GO:0110096 cellular response to aldehyde 1/1036 10/18670 0.4351 0.8159 0.7205 AKR1B1 1 GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus 1/1036 10/18670 0.4351 0.8159 0.7205 TLR6 1 GO:1900122 positive regulation of receptor binding 1/1036 10/18670 0.4351 0.8159 0.7205 PLCL1 1 GO:1901033 positive regulation of response to reactive oxygen species 1/1036 10/18670 0.4351 0.8159 0.7205 TNF 1 GO:1901526 positive regulation of mitophagy 1/1036 10/18670 0.4351 0.8159 0.7205 OPTN 1 GO:1901725 regulation of histone deacetylase activity 1/1036 10/18670 0.4351 0.8159 0.7205 SPHK2 1 GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1036 10/18670 0.4351 0.8159 0.7205 NOL11 1 GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/1036 10/18670 0.4351 0.8159 0.7205 ANAPC5 1 GO:1902915 negative regulation of protein polyubiquitination 1/1036 10/18670 0.4351 0.8159 0.7205 TRIM44 1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA 1/1036 10/18670 0.4351 0.8159 0.7205 NCOR1 1 GO:1903862 positive regulation of oxidative phosphorylation 1/1036 10/18670 0.4351 0.8159 0.7205 PGK1 1 GO:1903897 regulation of PERK-mediated unfolded protein response 1/1036 10/18670 0.4351 0.8159 0.7205 NCK1 1 GO:1904350 regulation of protein catabolic process in the vacuole 1/1036 10/18670 0.4351 0.8159 0.7205 LRP1 1 GO:1904526 regulation of microtubule binding 1/1036 10/18670 0.4351 0.8159 0.7205 MAP2 1 GO:1904684 negative regulation of metalloendopeptidase activity 1/1036 10/18670 0.4351 0.8159 0.7205 RECK 1 GO:1990253 cellular response to leucine starvation 1/1036 10/18670 0.4351 0.8159 0.7205 SESN1 1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 1/1036 10/18670 0.4351 0.8159 0.7205 EIF4A3 1 GO:2000109 regulation of macrophage apoptotic process 1/1036 10/18670 0.4351 0.8159 0.7205 CCL5 1 GO:2000317 negative regulation of T-helper 17 type immune response 1/1036 10/18670 0.4351 0.8159 0.7205 TBX21 1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity 1/1036 10/18670 0.4351 0.8159 0.7205 PRKAR2B 1 GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 1/1036 10/18670 0.4351 0.8159 0.7205 FGF18 1 GO:2000849 regulation of glucocorticoid secretion 1/1036 10/18670 0.4351 0.8159 0.7205 CRY1 1 GO:2001135 regulation of endocytic recycling 1/1036 10/18670 0.4351 0.8159 0.7205 EHD2 1 GO:0032886 regulation of microtubule-based process 13/1036 218/18670 0.4354 0.8159 0.7205 TRIM37/CKAP2/MAP2/NPM1/CEP76/RANGRF/CLASP1/ATAT1/IGBP1/DYRK1A/RNF4/TERF1/FEZ1 13 GO:0001910 regulation of leukocyte mediated cytotoxicity 5/1036 78/18670 0.4369 0.8159 0.7205 SH2D1A/IL12B/CD1A/RASGRP1/IL23A 5 GO:0043244 regulation of protein complex disassembly 7/1036 113/18670 0.4384 0.8159 0.7205 ADD3/TNF/CKAP2/FYCO1/CLASP1/SETX/SH3BP1 7 GO:0006879 cellular iron ion homeostasis 4/1036 61/18670 0.4408 0.8159 0.7205 MYC/SKP1/CUL1/SOD1 4 GO:1905953 negative regulation of lipid localization 4/1036 61/18670 0.4408 0.8159 0.7205 NFKB1/IL6/CRY1/TNF 4 GO:0003197 endocardial cushion development 3/1036 44/18670 0.4445 0.8159 0.7205 TGFBR2/ACVR1/ERBB3 3 GO:0007019 microtubule depolymerization 3/1036 44/18670 0.4445 0.8159 0.7205 KIF2A/CKAP2/CLASP1 3 GO:0007080 mitotic metaphase plate congression 3/1036 44/18670 0.4445 0.8159 0.7205 CDC23/NDC80/RRS1 3 GO:0010463 mesenchymal cell proliferation 3/1036 44/18670 0.4445 0.8159 0.7205 MYC/TGFBR2/SIX2 3 GO:0034105 positive regulation of tissue remodeling 3/1036 44/18670 0.4445 0.8159 0.7205 IL12B/IL23A/IL15 3 GO:0035850 epithelial cell differentiation involved in kidney development 3/1036 44/18670 0.4445 0.8159 0.7205 PRKX/LIF/SIX2 3 GO:0042269 regulation of natural killer cell mediated cytotoxicity 3/1036 44/18670 0.4445 0.8159 0.7205 SH2D1A/IL12B/RASGRP1 3 GO:0042987 amyloid precursor protein catabolic process 3/1036 44/18670 0.4445 0.8159 0.7205 IFNG/TNF/DYRK1A 3 GO:0044060 regulation of endocrine process 3/1036 44/18670 0.4445 0.8159 0.7205 IL1B/GNAS/CRY1 3 GO:0050654 chondroitin sulfate proteoglycan metabolic process 3/1036 44/18670 0.4445 0.8159 0.7205 SLC35D1/CHST12/CHPF2 3 GO:0050982 detection of mechanical stimulus 3/1036 44/18670 0.4445 0.8159 0.7205 PIEZO2/FYN/CXCR4 3 GO:1902667 regulation of axon guidance 3/1036 44/18670 0.4445 0.8159 0.7205 SEMA4G/SEMA3G/DSCAM 3 GO:0009267 cellular response to starvation 9/1036 149/18670 0.446 0.8159 0.7205 ATG14/SESN1/ATF3/XBP1/MAPK3/AKR1C3/PMAIP1/SLC38A2/ATG5 9 GO:0014074 response to purine-containing compound 9/1036 149/18670 0.446 0.8159 0.7205 IL1B/P2RX5/P2RX1/TRPM2/FDX1/P2RX6/SOD1/KCNQ1/NDUFS4 9 GO:1903900 regulation of viral life cycle 9/1036 149/18670 0.446 0.8159 0.7205 CCL5/PTX3/LAMP3/TNF/RSAD2/PABPC1/APOBEC3G/VPS37B/FCN1 9 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 9/1036 149/18670 0.446 0.8159 0.7205 RCHY1/GCLC/RBX1/RPS7/TRIB2/CSNK2A2/PSMD10/WAC/RPL11 9 GO:0000188 inactivation of MAPK activity 2/1036 27/18670 0.4464 0.8159 0.7205 DUSP2/DUSP21 2 GO:0001964 startle response 2/1036 27/18670 0.4464 0.8159 0.7205 GLRA1/GRIN2D 2 GO:0002026 regulation of the force of heart contraction 2/1036 27/18670 0.4464 0.8159 0.7205 ATP2A2/CHGA 2 GO:0006735 NADH regeneration 2/1036 27/18670 0.4464 0.8159 0.7205 PGK1/PFKP 2 GO:0006884 cell volume homeostasis 2/1036 27/18670 0.4464 0.8159 0.7205 SLC12A5/CLNS1A 2 GO:0009649 entrainment of circadian clock 2/1036 27/18670 0.4464 0.8159 0.7205 CRY1/PPP1CC 2 GO:0034067 protein localization to Golgi apparatus 2/1036 27/18670 0.4464 0.8159 0.7205 OPTN/PAQR3 2 GO:0042501 serine phosphorylation of STAT protein 2/1036 27/18670 0.4464 0.8159 0.7205 IFNG/LIF 2 GO:0050820 positive regulation of coagulation 2/1036 27/18670 0.4464 0.8159 0.7205 ENPP4/F12 2 GO:0051569 regulation of histone H3-K4 methylation 2/1036 27/18670 0.4464 0.8159 0.7205 AUTS2/CTR9 2 GO:0060259 regulation of feeding behavior 2/1036 27/18670 0.4464 0.8159 0.7205 TRH/NMU 2 GO:0061621 canonical glycolysis 2/1036 27/18670 0.4464 0.8159 0.7205 PGK1/PFKP 2 GO:0061718 glucose catabolic process to pyruvate 2/1036 27/18670 0.4464 0.8159 0.7205 PGK1/PFKP 2 GO:0072207 metanephric epithelium development 2/1036 27/18670 0.4464 0.8159 0.7205 LIF/ACAT1 2 GO:0072378 blood coagulation, fibrin clot formation 2/1036 27/18670 0.4464 0.8159 0.7205 C1QBP/F12 2 GO:0005976 polysaccharide metabolic process 7/1036 114/18670 0.4475 0.8159 0.7205 DYRK2/NFKB1/PASK/UGP2/PPP1CC/PHKG1/B3GNT2 7 GO:0008543 fibroblast growth factor receptor signaling pathway 7/1036 114/18670 0.4475 0.8159 0.7205 CEP57/HNRNPF/TIA1/SULF1/MAPK3/SETX/FGF18 7 GO:0001570 vasculogenesis 5/1036 79/18670 0.4479 0.8159 0.7205 TGFBR2/RASA1/TGFBR3/EMP2/HEG1 5 GO:0030193 regulation of blood coagulation 5/1036 79/18670 0.4479 0.8159 0.7205 ABAT/ENPP4/PRKCQ/F12/CD9 5 GO:0055072 iron ion homeostasis 5/1036 79/18670 0.4479 0.8159 0.7205 MYC/SKP1/CUL1/SOD1/RHAG 5 GO:0002526 acute inflammatory response 13/1036 220/18670 0.4486 0.8159 0.7205 IL1A/IL6/IL1B/C1QBP/HP/ACVR1/TNF/F12/C8B/ELANE/CD163/CD5L/LBP 13 GO:0030258 lipid modification 14/1036 238/18670 0.4504 0.8159 0.7205 ABCD3/CHRM5/ACADM/ETFA/PIK3CA/SCP2/SPHK2/DGKZ/PIK3C2A/AGK/PIK3R1/ABO/ACAT1/CERK 14 GO:0001503 ossification 23/1036 398/18670 0.451 0.8159 0.7205 IL6/FBL/CAT/GNAS/PSMC2/ACVR1/ASGR2/TNF/HIRA/BMPR1B/MN1/DDX21/HSPE1/MAPK3/RRAS2/HDAC4/PDLIM7/PTGER4/FBXO5/ZBTB16/FGF18/SIX2/GFRA4 23 GO:0042552 myelination 8/1036 132/18670 0.451 0.8159 0.7205 CTSC/CXCR4/RARA/MPZ/MBP/CST7/CD9/SOD1 8 GO:0010771 negative regulation of cell morphogenesis involved in differentiation 6/1036 97/18670 0.4529 0.8159 0.7205 ARHGAP4/MAP2/SEMA4G/SEMA3G/NTN1/EFNB3 6 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 4/1036 62/18670 0.4533 0.8159 0.7205 TNFSF13/MSH2/TBX21/BCL11B 4 GO:0007585 respiratory gaseous exchange 4/1036 62/18670 0.4533 0.8159 0.7205 PASK/NTSR1/GLRA1/TLX3 4 GO:0009584 detection of visible light 4/1036 62/18670 0.4533 0.8159 0.7205 METAP1/FNTA/BEST1/METAP2 4 GO:0016444 somatic cell DNA recombination 4/1036 62/18670 0.4533 0.8159 0.7205 TNFSF13/MSH2/TBX21/BCL11B 4 GO:0046824 positive regulation of nucleocytoplasmic transport 4/1036 62/18670 0.4533 0.8159 0.7205 IFNG/IL1B/RIOK2/PIK3R1 4 GO:0070265 necrotic cell death 4/1036 62/18670 0.4533 0.8159 0.7205 BIRC3/TNF/DNM1L/TLR3 4 GO:0048754 branching morphogenesis of an epithelial tube 9/1036 150/18670 0.4539 0.8159 0.7205 MYC/TGFBR2/MAGED1/ACVR1/TNF/PHB2/RBM15/CCL11/SIX2 9 GO:0050777 negative regulation of immune response 9/1036 150/18670 0.4539 0.8159 0.7205 CD96/IL12B/PSMA1/TNF/ANXA1/TBX21/SLAMF8/PGLYRP4/BCR 9 GO:0051302 regulation of cell division 10/1036 168/18670 0.4563 0.8159 0.7205 LBH/MYC/IL1A/IL1B/FLCN/AURKC/CDC25B/CAT/NCOA3/PRC1 10 GO:0032963 collagen metabolic process 7/1036 115/18670 0.4566 0.8159 0.7205 IL6/ADAMTS2/CTSD/PLOD1/ADAM15/RCN3/CBX8 7 GO:0046660 female sex differentiation 7/1036 115/18670 0.4566 0.8159 0.7205 ARID5B/NUP107/PTX3/BMPR1B/AMHR2/UBB/SOD1 7 GO:0070507 regulation of microtubule cytoskeleton organization 11/1036 186/18670 0.4584 0.8159 0.7205 TRIM37/CKAP2/MAP2/NPM1/CEP76/RANGRF/CLASP1/ATAT1/DYRK1A/RNF4/TERF1 11 GO:0048194 Golgi vesicle budding 5/1036 80/18670 0.4589 0.8159 0.7205 CTSC/INSIG1/SCFD1/SEC24A/TMED2 5 GO:0070509 calcium ion import 5/1036 80/18670 0.4589 0.8159 0.7205 ATP2A2/FYN/FAM155B/TRPM2/SPHK2 5 GO:0097061 dendritic spine organization 5/1036 80/18670 0.4589 0.8159 0.7205 FYN/CAPRIN2/DNM1L/DBN1/CAPRIN1 5 GO:1900046 regulation of hemostasis 5/1036 80/18670 0.4589 0.8159 0.7205 ABAT/ENPP4/PRKCQ/F12/CD9 5 GO:0010038 response to metal ion 21/1036 364/18670 0.4591 0.8159 0.7205 PCNA/PARP1/ABAT/IL1A/CAT/SOD3/NPC1/CPNE6/GCLC/TRPM2/CPNE3/QDPR/GLRA1/MAPK3/KCNH1/OTC/AKR1C3/DAXX/CYB5A/SOD1/MCOLN1 21 GO:0001974 blood vessel remodeling 3/1036 45/18670 0.4592 0.8159 0.7205 LIF/BCR/ATG5 3 GO:0010569 regulation of double-strand break repair via homologous recombination 3/1036 45/18670 0.4592 0.8159 0.7205 PARP1/WAS/POLQ 3 GO:0035987 endodermal cell differentiation 3/1036 45/18670 0.4592 0.8159 0.7205 CTR9/ITGA4/ITGA7 3 GO:0048538 thymus development 3/1036 45/18670 0.4592 0.8159 0.7205 BCL11B/MAPK3/SOD1 3 GO:0051932 synaptic transmission, GABAergic 3/1036 45/18670 0.4592 0.8159 0.7205 PLCL1/GABRB2/CA7 3 GO:0071827 plasma lipoprotein particle organization 3/1036 45/18670 0.4592 0.8159 0.7205 CETP/PRKACB/ACSL3 3 GO:1900274 regulation of phospholipase C activity 3/1036 45/18670 0.4592 0.8159 0.7205 TXK/ITK/AVPR1B 3 GO:0009581 detection of external stimulus 8/1036 133/18670 0.4595 0.8159 0.7205 METAP1/PIEZO2/FYN/NTSR1/FNTA/CXCR4/BEST1/METAP2 8 GO:0031023 microtubule organizing center organization 8/1036 133/18670 0.4595 0.8159 0.7205 TRIM37/NPM1/HAUS2/UXT/PCM1/CEP76/CLASP1/XRCC2 8 GO:0071333 cellular response to glucose stimulus 8/1036 133/18670 0.4595 0.8159 0.7205 TRA2B/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/GHRHR 8 GO:0042472 inner ear morphogenesis 6/1036 98/18670 0.4627 0.8159 0.7205 INSIG1/LRIG1/SOD1/NTN1/FZD2/BCR 6 GO:0046364 monosaccharide biosynthetic process 6/1036 98/18670 0.4627 0.8159 0.7205 MDH1/PGK1/CRY1/ATF3/CLK2/AKR1B1 6 GO:0060191 regulation of lipase activity 6/1036 98/18670 0.4627 0.8159 0.7205 CCL5/TXK/ANXA1/ITK/LRP1/AVPR1B 6 GO:0030307 positive regulation of cell growth 10/1036 169/18670 0.4638 0.8159 0.7205 CD38/CPNE6/CXCR4/LRP1/DBN1/PSMD10/DSCAM/NTN1/ADNP/RPS6KA3 10 GO:0006486 protein glycosylation 15/1036 258/18670 0.4642 0.8159 0.7205 ST3GAL5/ALG13/POGLUT1/NPC1/ASGR2/MUC2/ASGR1/IL15/MAN1A1/MGAT2/GALNT10/B3GNT2/ABO/UBE2J1/GFPT1 15 GO:0043406 positive regulation of MAP kinase activity 15/1036 258/18670 0.4642 0.8159 0.7205 IL1B/MAGED1/TNF/CXCR4/RASGRP1/MAP4K5/MAPK3/UBA52/ELANE/MAP4K2/TLR6/DAXX/UBB/SOD1/FGF18 15 GO:0043413 macromolecule glycosylation 15/1036 258/18670 0.4642 0.8159 0.7205 ST3GAL5/ALG13/POGLUT1/NPC1/ASGR2/MUC2/ASGR1/IL15/MAN1A1/MGAT2/GALNT10/B3GNT2/ABO/UBE2J1/GFPT1 15 GO:0032102 negative regulation of response to external stimulus 21/1036 365/18670 0.4643 0.8159 0.7205 ABAT/NFKB1/C1QBP/GPR18/RORA/WFDC1/IL12B/PSMA1/HTRA1/F12/SEMA4G/CST7/ELANE/SEMA3G/PTGER4/CLASP1/CD9/SOD1/SLAMF8/GPATCH3/BCR 21 GO:0006631 fatty acid metabolic process 22/1036 383/18670 0.465 0.8159 0.7205 ABCD3/CREM/IL1B/MSMO1/DLD/INSIG1/ACADM/ANXA1/LIPE/XBP1/ETFA/PRKAR2B/MAPK3/SCP2/PON1/CYP2C9/AKR1C3/ACSL3/PLA2G3/CYP4A11/ACAT1/CYP4F12 22 GO:0001958 endochondral ossification 2/1036 28/18670 0.4653 0.8159 0.7205 GNAS/FGF18 2 GO:0006972 hyperosmotic response 2/1036 28/18670 0.4653 0.8159 0.7205 TLR3/AKR1B1 2 GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 2/1036 28/18670 0.4653 0.8159 0.7205 LRP1/DGKZ 2 GO:0008045 motor neuron axon guidance 2/1036 28/18670 0.4653 0.8159 0.7205 LHX3/NTN1 2 GO:0031440 regulation of mRNA 3'-end processing 2/1036 28/18670 0.4653 0.8159 0.7205 CTR9/NUDT21 2 GO:0032196 transposition 2/1036 28/18670 0.4653 0.8159 0.7205 MYBL1/APOBEC3G 2 GO:0034377 plasma lipoprotein particle assembly 2/1036 28/18670 0.4653 0.8159 0.7205 PRKACB/ACSL3 2 GO:0034698 response to gonadotropin 2/1036 28/18670 0.4653 0.8159 0.7205 GCLC/TGFBR3 2 GO:0035116 embryonic hindlimb morphogenesis 2/1036 28/18670 0.4653 0.8159 0.7205 GNAS/ZBTB16 2 GO:0036075 replacement ossification 2/1036 28/18670 0.4653 0.8159 0.7205 GNAS/FGF18 2 GO:0045577 regulation of B cell differentiation 2/1036 28/18670 0.4653 0.8159 0.7205 XBP1/SLAMF8 2 GO:0048520 positive regulation of behavior 2/1036 28/18670 0.4653 0.8159 0.7205 HDAC4/GHRHR 2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 2/1036 28/18670 0.4653 0.8159 0.7205 PTPN22/LILRB4 2 GO:0051647 nucleus localization 2/1036 28/18670 0.4653 0.8159 0.7205 PCM1/NTN1 2 GO:0051984 positive regulation of chromosome segregation 2/1036 28/18670 0.4653 0.8159 0.7205 SFPQ/ANAPC5 2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2/1036 28/18670 0.4653 0.8159 0.7205 PSMC2/PSMC5 2 GO:0061615 glycolytic process through fructose-6-phosphate 2/1036 28/18670 0.4653 0.8159 0.7205 PGK1/PFKP 2 GO:0061620 glycolytic process through glucose-6-phosphate 2/1036 28/18670 0.4653 0.8159 0.7205 PGK1/PFKP 2 GO:0070076 histone lysine demethylation 2/1036 28/18670 0.4653 0.8159 0.7205 KDM5C/KDM5D 2 GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/1036 28/18670 0.4653 0.8159 0.7205 ATP1B1/KCNQ1 2 GO:0095500 acetylcholine receptor signaling pathway 2/1036 28/18670 0.4653 0.8159 0.7205 CHRM5/CHRM2 2 GO:1902003 regulation of amyloid-beta formation 2/1036 28/18670 0.4653 0.8159 0.7205 IFNG/TNF 2 GO:1902668 negative regulation of axon guidance 2/1036 28/18670 0.4653 0.8159 0.7205 SEMA4G/SEMA3G 2 GO:1903792 negative regulation of anion transport 2/1036 28/18670 0.4653 0.8159 0.7205 ABAT/TRH 2 GO:1903831 signal transduction involved in cellular response to ammonium ion 2/1036 28/18670 0.4653 0.8159 0.7205 CHRM5/CHRM2 2 GO:2000108 positive regulation of leukocyte apoptotic process 2/1036 28/18670 0.4653 0.8159 0.7205 CCL5/ANXA1 2 GO:0070252 actin-mediated cell contraction 7/1036 116/18670 0.4657 0.8159 0.7205 MYL1/PDE4B/TNNI1/EMP2/PARVA/GPD1L/KCNQ1 7 GO:0006893 Golgi to plasma membrane transport 4/1036 63/18670 0.4657 0.8159 0.7205 OPTN/ANXA13/C16orf70/ACSL3 4 GO:0007062 sister chromatid cohesion 4/1036 63/18670 0.4657 0.8159 0.7205 SFPQ/PHB2/TNKS/ATRX 4 GO:0031646 positive regulation of neurological system process 4/1036 63/18670 0.4657 0.8159 0.7205 ABAT/NTSR1/CST7/NMU 4 GO:0000050 urea cycle 1/1036 11/18670 0.4664 0.8159 0.7205 OTC 1 GO:0001574 ganglioside biosynthetic process 1/1036 11/18670 0.4664 0.8159 0.7205 ST3GAL5 1 GO:0002836 positive regulation of response to tumor cell 1/1036 11/18670 0.4664 0.8159 0.7205 IL12B 1 GO:0002839 positive regulation of immune response to tumor cell 1/1036 11/18670 0.4664 0.8159 0.7205 IL12B 1 GO:0002887 negative regulation of myeloid leukocyte mediated immunity 1/1036 11/18670 0.4664 0.8159 0.7205 BCR 1 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 1/1036 11/18670 0.4664 0.8159 0.7205 TNF 1 GO:0003093 regulation of glomerular filtration 1/1036 11/18670 0.4664 0.8159 0.7205 EMP2 1 GO:0003174 mitral valve development 1/1036 11/18670 0.4664 0.8159 0.7205 ACVR1 1 GO:0006054 N-acetylneuraminate metabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 GNE 1 GO:0006558 L-phenylalanine metabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 QDPR 1 GO:0006559 L-phenylalanine catabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 QDPR 1 GO:0009125 nucleoside monophosphate catabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 NUDT9 1 GO:0010172 embryonic body morphogenesis 1/1036 11/18670 0.4664 0.8159 0.7205 CLASP1 1 GO:0010986 positive regulation of lipoprotein particle clearance 1/1036 11/18670 0.4664 0.8159 0.7205 LDLRAP1 1 GO:0014870 response to muscle inactivity 1/1036 11/18670 0.4664 0.8159 0.7205 HDAC4 1 GO:0015791 polyol transport 1/1036 11/18670 0.4664 0.8159 0.7205 PGAP1 1 GO:0019371 cyclooxygenase pathway 1/1036 11/18670 0.4664 0.8159 0.7205 AKR1C3 1 GO:0021521 ventral spinal cord interneuron specification 1/1036 11/18670 0.4664 0.8159 0.7205 LHX3 1 GO:0021534 cell proliferation in hindbrain 1/1036 11/18670 0.4664 0.8159 0.7205 RORA 1 GO:0030309 poly-N-acetyllactosamine metabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 B3GNT2 1 GO:0031442 positive regulation of mRNA 3'-end processing 1/1036 11/18670 0.4664 0.8159 0.7205 NUDT21 1 GO:0031915 positive regulation of synaptic plasticity 1/1036 11/18670 0.4664 0.8159 0.7205 DBN1 1 GO:0032060 bleb assembly 1/1036 11/18670 0.4664 0.8159 0.7205 EMP2 1 GO:0032306 regulation of prostaglandin secretion 1/1036 11/18670 0.4664 0.8159 0.7205 IL1B 1 GO:0032494 response to peptidoglycan 1/1036 11/18670 0.4664 0.8159 0.7205 IL6 1 GO:0032908 regulation of transforming growth factor beta1 production 1/1036 11/18670 0.4664 0.8159 0.7205 CD2AP 1 GO:0033089 positive regulation of T cell differentiation in thymus 1/1036 11/18670 0.4664 0.8159 0.7205 RASGRP1 1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/1036 11/18670 0.4664 0.8159 0.7205 PARP1 1 GO:0033234 negative regulation of protein sumoylation 1/1036 11/18670 0.4664 0.8159 0.7205 HMG20A 1 GO:0033860 regulation of NAD(P)H oxidase activity 1/1036 11/18670 0.4664 0.8159 0.7205 SLAMF8 1 GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/1036 11/18670 0.4664 0.8159 0.7205 MBP 1 GO:0034379 very-low-density lipoprotein particle assembly 1/1036 11/18670 0.4664 0.8159 0.7205 ACSL3 1 GO:0034776 response to histamine 1/1036 11/18670 0.4664 0.8159 0.7205 GABRB2 1 GO:0035457 cellular response to interferon-alpha 1/1036 11/18670 0.4664 0.8159 0.7205 IFIT2 1 GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/1036 11/18670 0.4664 0.8159 0.7205 TGFBR2 1 GO:0035747 natural killer cell chemotaxis 1/1036 11/18670 0.4664 0.8159 0.7205 CCL5 1 GO:0035766 cell chemotaxis to fibroblast growth factor 1/1036 11/18670 0.4664 0.8159 0.7205 FGF18 1 GO:0035933 glucocorticoid secretion 1/1036 11/18670 0.4664 0.8159 0.7205 CRY1 1 GO:0036462 TRAIL-activated apoptotic signaling pathway 1/1036 11/18670 0.4664 0.8159 0.7205 ATF3 1 GO:0042023 DNA endoreduplication 1/1036 11/18670 0.4664 0.8159 0.7205 FBXO5 1 GO:0043129 surfactant homeostasis 1/1036 11/18670 0.4664 0.8159 0.7205 RCN3 1 GO:0044793 negative regulation by host of viral process 1/1036 11/18670 0.4664 0.8159 0.7205 PTX3 1 GO:0045141 meiotic telomere clustering 1/1036 11/18670 0.4664 0.8159 0.7205 TERF1 1 GO:0045217 cell-cell junction maintenance 1/1036 11/18670 0.4664 0.8159 0.7205 KIFC3 1 GO:0045351 type I interferon biosynthetic process 1/1036 11/18670 0.4664 0.8159 0.7205 TLR3 1 GO:0046185 aldehyde catabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 ALDH3B1 1 GO:0046512 sphingosine biosynthetic process 1/1036 11/18670 0.4664 0.8159 0.7205 SPHK2 1 GO:0048672 positive regulation of collateral sprouting 1/1036 11/18670 0.4664 0.8159 0.7205 LRP1 1 GO:0048680 positive regulation of axon regeneration 1/1036 11/18670 0.4664 0.8159 0.7205 LRP1 1 GO:0048742 regulation of skeletal muscle fiber development 1/1036 11/18670 0.4664 0.8159 0.7205 HDAC4 1 GO:0051791 medium-chain fatty acid metabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 ACADM 1 GO:0051974 negative regulation of telomerase activity 1/1036 11/18670 0.4664 0.8159 0.7205 TERF1 1 GO:0055015 ventricular cardiac muscle cell development 1/1036 11/18670 0.4664 0.8159 0.7205 ATG5 1 GO:0060088 auditory receptor cell stereocilium organization 1/1036 11/18670 0.4664 0.8159 0.7205 SOD1 1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 1/1036 11/18670 0.4664 0.8159 0.7205 CLIC2 1 GO:0060433 bronchus development 1/1036 11/18670 0.4664 0.8159 0.7205 TGFBR2 1 GO:0060573 cell fate specification involved in pattern specification 1/1036 11/18670 0.4664 0.8159 0.7205 LHX3 1 GO:0060767 epithelial cell proliferation involved in prostate gland development 1/1036 11/18670 0.4664 0.8159 0.7205 STK11 1 GO:0060856 establishment of blood-brain barrier 1/1036 11/18670 0.4664 0.8159 0.7205 RECK 1 GO:0061307 cardiac neural crest cell differentiation involved in heart development 1/1036 11/18670 0.4664 0.8159 0.7205 MAPK3 1 GO:0061308 cardiac neural crest cell development involved in heart development 1/1036 11/18670 0.4664 0.8159 0.7205 MAPK3 1 GO:0070254 mucus secretion 1/1036 11/18670 0.4664 0.8159 0.7205 ATG5 1 GO:0070471 uterine smooth muscle contraction 1/1036 11/18670 0.4664 0.8159 0.7205 ABAT 1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/1036 11/18670 0.4664 0.8159 0.7205 MBP 1 GO:0070757 interleukin-35-mediated signaling pathway 1/1036 11/18670 0.4664 0.8159 0.7205 STAT4 1 GO:0070933 histone H4 deacetylation 1/1036 11/18670 0.4664 0.8159 0.7205 HDAC4 1 GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/1036 11/18670 0.4664 0.8159 0.7205 GCLC 1 GO:0071803 positive regulation of podosome assembly 1/1036 11/18670 0.4664 0.8159 0.7205 TNF 1 GO:0072537 fibroblast activation 1/1036 11/18670 0.4664 0.8159 0.7205 GCLC 1 GO:0072584 caveolin-mediated endocytosis 1/1036 11/18670 0.4664 0.8159 0.7205 MAPK3 1 GO:0072611 interleukin-13 secretion 1/1036 11/18670 0.4664 0.8159 0.7205 SPHK2 1 GO:0072683 T cell extravasation 1/1036 11/18670 0.4664 0.8159 0.7205 CD99 1 GO:0072711 cellular response to hydroxyurea 1/1036 11/18670 0.4664 0.8159 0.7205 ATRX 1 GO:0086016 AV node cell action potential 1/1036 11/18670 0.4664 0.8159 0.7205 SCN10A 1 GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 1/1036 11/18670 0.4664 0.8159 0.7205 CHGA 1 GO:0086027 AV node cell to bundle of His cell signaling 1/1036 11/18670 0.4664 0.8159 0.7205 SCN10A 1 GO:0090394 negative regulation of excitatory postsynaptic potential 1/1036 11/18670 0.4664 0.8159 0.7205 EIF4A3 1 GO:0090657 telomeric loop disassembly 1/1036 11/18670 0.4664 0.8159 0.7205 TERF1 1 GO:0099624 atrial cardiac muscle cell membrane repolarization 1/1036 11/18670 0.4664 0.8159 0.7205 KCNQ1 1 GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 1/1036 11/18670 0.4664 0.8159 0.7205 NCK1 1 GO:1900112 regulation of histone H3-K9 trimethylation 1/1036 11/18670 0.4664 0.8159 0.7205 ATRX 1 GO:1901096 regulation of autophagosome maturation 1/1036 11/18670 0.4664 0.8159 0.7205 FYCO1 1 GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 QDPR 1 GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 QDPR 1 GO:1902563 regulation of neutrophil activation 1/1036 11/18670 0.4664 0.8159 0.7205 BCR 1 GO:1903977 positive regulation of glial cell migration 1/1036 11/18670 0.4664 0.8159 0.7205 LRP1 1 GO:1903980 positive regulation of microglial cell activation 1/1036 11/18670 0.4664 0.8159 0.7205 CTSC 1 GO:1904321 response to forskolin 1/1036 11/18670 0.4664 0.8159 0.7205 FDX1 1 GO:1904322 cellular response to forskolin 1/1036 11/18670 0.4664 0.8159 0.7205 FDX1 1 GO:1904847 regulation of cell chemotaxis to fibroblast growth factor 1/1036 11/18670 0.4664 0.8159 0.7205 FGF18 1 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 1/1036 11/18670 0.4664 0.8159 0.7205 CCL25 1 GO:1905146 lysosomal protein catabolic process 1/1036 11/18670 0.4664 0.8159 0.7205 LRP1 1 GO:1905214 regulation of RNA binding 1/1036 11/18670 0.4664 0.8159 0.7205 EIF4A3 1 GO:1905820 positive regulation of chromosome separation 1/1036 11/18670 0.4664 0.8159 0.7205 ANAPC5 1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1/1036 11/18670 0.4664 0.8159 0.7205 ATF3 1 GO:2000392 regulation of lamellipodium morphogenesis 1/1036 11/18670 0.4664 0.8159 0.7205 ARHGEF7 1 GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/1036 11/18670 0.4664 0.8159 0.7205 TGFBR2 1 GO:2000615 regulation of histone H3-K9 acetylation 1/1036 11/18670 0.4664 0.8159 0.7205 SPHK2 1 GO:0042742 defense response to bacterium 19/1036 330/18670 0.4679 0.8164 0.7209 DROSHA/OPTN/IL6/LYZ/IL12B/HP/CHGA/TNF/ANKRD17/TLR3/IL23A/ELANE/TLR6/STAB1/CTSG/SLAMF8/PGLYRP4/TRBC1/LBP 19 GO:0007272 ensheathment of neurons 8/1036 134/18670 0.4679 0.8164 0.7209 CTSC/CXCR4/RARA/MPZ/MBP/CST7/CD9/SOD1 8 GO:0008366 axon ensheathment 8/1036 134/18670 0.4679 0.8164 0.7209 CTSC/CXCR4/RARA/MPZ/MBP/CST7/CD9/SOD1 8 GO:0030260 entry into host cell 8/1036 134/18670 0.4679 0.8164 0.7209 SLAMF1/PTX3/NPC1/CXCR4/EXOC7/FCN1/EFNB3/CBLL1 8 GO:0044409 entry into host 8/1036 134/18670 0.4679 0.8164 0.7209 SLAMF1/PTX3/NPC1/CXCR4/EXOC7/FCN1/EFNB3/CBLL1 8 GO:0046683 response to organophosphorus 8/1036 134/18670 0.4679 0.8164 0.7209 IL1B/P2RX5/P2RX1/FDX1/P2RX6/SOD1/KCNQ1/NDUFS4 8 GO:0051806 entry into cell of other organism involved in symbiotic interaction 8/1036 134/18670 0.4679 0.8164 0.7209 SLAMF1/PTX3/NPC1/CXCR4/EXOC7/FCN1/EFNB3/CBLL1 8 GO:0051828 entry into other organism involved in symbiotic interaction 8/1036 134/18670 0.4679 0.8164 0.7209 SLAMF1/PTX3/NPC1/CXCR4/EXOC7/FCN1/EFNB3/CBLL1 8 GO:0007045 cell-substrate adherens junction assembly 5/1036 81/18670 0.4697 0.818 0.7224 LRP1/ARHGEF7/ACTN1/CLASP1/BCR 5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 5/1036 81/18670 0.4697 0.818 0.7224 RCHY1/GCLC/RBX1/TRIB2/PSMD10 5 GO:0048041 focal adhesion assembly 5/1036 81/18670 0.4697 0.818 0.7224 LRP1/ARHGEF7/ACTN1/CLASP1/BCR 5 GO:2001021 negative regulation of response to DNA damage stimulus 5/1036 81/18670 0.4697 0.818 0.7224 DYRK3/FBXO5/PSMD10/DYRK1A/POLQ 5 GO:0001678 cellular glucose homeostasis 9/1036 152/18670 0.4698 0.818 0.7224 TRA2B/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/GHRHR/PIK3R1 9 GO:0001890 placenta development 9/1036 152/18670 0.4698 0.818 0.7224 HTRA1/LHX3/SPINT1/MAPK3/LIF/RBM15/BPTF/SOD1/TMED2 9 GO:0071772 response to BMP 10/1036 170/18670 0.4713 0.8187 0.7229 FKBP8/USP9Y/HTRA1/ACVR1/TGFBR3/BMPR1B/SPINT1/SULF1/MAPK3/AMHR2 10 GO:0071773 cellular response to BMP stimulus 10/1036 170/18670 0.4713 0.8187 0.7229 FKBP8/USP9Y/HTRA1/ACVR1/TGFBR3/BMPR1B/SPINT1/SULF1/MAPK3/AMHR2 10 GO:0072527 pyrimidine-containing compound metabolic process 6/1036 99/18670 0.4726 0.8187 0.7229 DCK/CMPK1/PRPS1/UCKL1/AGPAT2/APOBEC3G 6 GO:0031345 negative regulation of cell projection organization 11/1036 188/18670 0.4726 0.8187 0.7229 CD38/ARHGAP4/FYN/MAP2/LRP1/SEMA4G/SEMA3G/NTN1/PAQR3/EFNB3/CRMP1 11 GO:0001504 neurotransmitter uptake 3/1036 46/18670 0.4737 0.8187 0.7229 SLC38A1/NTSR1/SLC1A3 3 GO:0010883 regulation of lipid storage 3/1036 46/18670 0.4737 0.8187 0.7229 NFKB1/IL6/TNF 3 GO:0031648 protein destabilization 3/1036 46/18670 0.4737 0.8187 0.7229 CCDC88C/DERL1/XBP1 3 GO:0043277 apoptotic cell clearance 3/1036 46/18670 0.4737 0.8187 0.7229 LRP1/RARA/FCN1 3 GO:0048599 oocyte development 3/1036 46/18670 0.4737 0.8187 0.7229 AURKC/CDC25B/FBXO5 3 GO:0050919 negative chemotaxis 3/1036 46/18670 0.4737 0.8187 0.7229 SEMA4G/SEMA3G/NTN1 3 GO:0097720 calcineurin-mediated signaling 3/1036 46/18670 0.4737 0.8187 0.7229 DYRK2/ERBB3/TNF 3 GO:1901653 cellular response to peptide 22/1036 385/18670 0.475 0.8187 0.7229 PARP1/NFKB1/SOS1/IL1B/NCK1/ITGA4/PRKCQ/PRKACB/GCLC/FYN/PTPN22/LRP1/XBP1/TBC1D4/PRKAR2B/PIK3CA/AKR1B1/PIK3C2A/TLR6/GHRHR/APRT/PIK3R1 22 GO:0032412 regulation of ion transmembrane transporter activity 15/1036 260/18670 0.4763 0.8187 0.7229 ABCB1/IFNG/CLIC2/CAPN1/NTSR1/PDE4B/PHB2/GPD1L/ATP1B1/SPHK2/JPH3/CACNB4/RANGRF/KCNS1/EHD3 15 GO:0071331 cellular response to hexose stimulus 8/1036 135/18670 0.4764 0.8187 0.7229 TRA2B/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/GHRHR 8 GO:0060485 mesenchyme development 16/1036 278/18670 0.477 0.8187 0.7229 MYC/IL6/TGFBR2/IL1B/POGLUT1/ACVR1/ERBB3/TGFBR3/SEMA4G/TSPY1/MAPK3/SEMA3G/CLASP1/CITED2/ADAM15/SIX2 16 GO:0016445 somatic diversification of immunoglobulins 4/1036 64/18670 0.478 0.8187 0.7229 TNFSF13/MSH2/TBX21/POLQ 4 GO:0032768 regulation of monooxygenase activity 4/1036 64/18670 0.478 0.8187 0.7229 NFKB1/IFNG/IL1B/TNF 4 GO:0043550 regulation of lipid kinase activity 4/1036 64/18670 0.478 0.8187 0.7229 ATG14/CCKBR/DGKZ/PIK3R1 4 GO:0045600 positive regulation of fat cell differentiation 4/1036 64/18670 0.478 0.8187 0.7229 ZFP36/XBP1/ASXL2/ZBTB16 4 GO:0060135 maternal process involved in female pregnancy 4/1036 64/18670 0.478 0.8187 0.7229 MAPK3/LIF/AKR1B1/TMED2 4 GO:0043901 negative regulation of multi-organism process 10/1036 171/18670 0.4788 0.8187 0.7229 CCL5/C1QBP/PTX3/ZFP36/HTRA1/TNF/RSAD2/APOBEC3G/FCN1/GPATCH3 10 GO:0006643 membrane lipid metabolic process 12/1036 207/18670 0.4805 0.8187 0.7229 ST3GAL5/CREM/ESYT1/P2RX1/TNF/CERS6/ARSA/SPHK2/ALDH3B1/AGK/PGAP1/CERK 12 GO:0006855 drug transmembrane transport 5/1036 82/18670 0.4806 0.8187 0.7229 SLC25A32/NTSR1/SLC7A5/RHAG/SLC1A3 5 GO:0051279 regulation of release of sequestered calcium ion into cytosol 5/1036 82/18670 0.4806 0.8187 0.7229 CXCL11/CLIC2/NTSR1/JPH3/ATG5 5 GO:0051702 interaction with symbiont 5/1036 82/18670 0.4806 0.8187 0.7229 CCL5/PTX3/RAB9A/ELANE/CTSG 5 GO:0022600 digestive system process 6/1036 100/18670 0.4824 0.8187 0.7229 CHRM5/MUC2/HRH2/CCKBR/KCNQ1/NMU 6 GO:0090174 organelle membrane fusion 6/1036 100/18670 0.4824 0.8187 0.7229 MFN1/ANXA1/STX10/STX8/TBC1D4/GOSR1 6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 2/1036 29/18670 0.4838 0.8187 0.7229 PCNA/FBXO5 2 GO:0003016 respiratory system process 2/1036 29/18670 0.4838 0.8187 0.7229 GLRA1/TLX3 2 GO:0005979 regulation of glycogen biosynthetic process 2/1036 29/18670 0.4838 0.8187 0.7229 DYRK2/PASK 2 GO:0010644 cell communication by electrical coupling 2/1036 29/18670 0.4838 0.8187 0.7229 ATP1B1/DBN1 2 GO:0010962 regulation of glucan biosynthetic process 2/1036 29/18670 0.4838 0.8187 0.7229 DYRK2/PASK 2 GO:0015949 nucleobase-containing small molecule interconversion 2/1036 29/18670 0.4838 0.8187 0.7229 AK6/CMPK1 2 GO:0016577 histone demethylation 2/1036 29/18670 0.4838 0.8187 0.7229 KDM5C/KDM5D 2 GO:0031063 regulation of histone deacetylation 2/1036 29/18670 0.4838 0.8187 0.7229 SPHK2/ZNHIT1 2 GO:0031114 regulation of microtubule depolymerization 2/1036 29/18670 0.4838 0.8187 0.7229 CKAP2/CLASP1 2 GO:0031116 positive regulation of microtubule polymerization 2/1036 29/18670 0.4838 0.8187 0.7229 CLASP1/TERF1 2 GO:0031365 N-terminal protein amino acid modification 2/1036 29/18670 0.4838 0.8187 0.7229 METAP1/METAP2 2 GO:0032232 negative regulation of actin filament bundle assembly 2/1036 29/18670 0.4838 0.8187 0.7229 WAS/CLASP1 2 GO:0033014 tetrapyrrole biosynthetic process 2/1036 29/18670 0.4838 0.8187 0.7229 SUCLA2/RSAD1 2 GO:0033032 regulation of myeloid cell apoptotic process 2/1036 29/18670 0.4838 0.8187 0.7229 CCL5/ANXA1 2 GO:0034367 protein-containing complex remodeling 2/1036 29/18670 0.4838 0.8187 0.7229 CETP/GTF2E1 2 GO:0050855 regulation of B cell receptor signaling pathway 2/1036 29/18670 0.4838 0.8187 0.7229 PRKCH/PTPN22 2 GO:0055075 potassium ion homeostasis 2/1036 29/18670 0.4838 0.8187 0.7229 SLC12A5/ATP1B1 2 GO:0070229 negative regulation of lymphocyte apoptotic process 2/1036 29/18670 0.4838 0.8187 0.7229 CCL5/PRKCQ 2 GO:0070528 protein kinase C signaling 2/1036 29/18670 0.4838 0.8187 0.7229 GPD1L/SPHK2 2 GO:0090162 establishment of epithelial cell polarity 2/1036 29/18670 0.4838 0.8187 0.7229 CLASP1/SH3BP1 2 GO:1900181 negative regulation of protein localization to nucleus 2/1036 29/18670 0.4838 0.8187 0.7229 FLCN/LILRB4 2 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 2/1036 29/18670 0.4838 0.8187 0.7229 ANXA1/TBX21 2 GO:2000765 regulation of cytoplasmic translation 2/1036 29/18670 0.4838 0.8187 0.7229 NCK1/CNBP 2 GO:0003002 regionalization 20/1036 351/18670 0.4844 0.8187 0.7229 AIDA/FKBP8/TRA2B/PRKACB/POGLUT1/BTG2/ACVR1/HSPB11/LHX3/BMPR1B/HOXA6/SMARCD3/MLLT3/CITED2/ZBTB16/BPTF/PGAP1/XRCC2/SIX2/TMED2 20 GO:0009582 detection of abiotic stimulus 8/1036 136/18670 0.4847 0.8187 0.7229 METAP1/PIEZO2/FYN/NTSR1/FNTA/CXCR4/BEST1/METAP2 8 GO:0071326 cellular response to monosaccharide stimulus 8/1036 136/18670 0.4847 0.8187 0.7229 TRA2B/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/GHRHR 8 GO:0071248 cellular response to metal ion 11/1036 190/18670 0.4868 0.8187 0.7229 PARP1/CPNE6/TRPM2/CPNE3/GLRA1/MAPK3/KCNH1/AKR1C3/DAXX/SOD1/MCOLN1 11 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3/1036 47/18670 0.4881 0.8187 0.7229 TNFSF13/MSH2/TBX21 3 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3/1036 47/18670 0.4881 0.8187 0.7229 TNFSF13/MSH2/TBX21 3 GO:0002832 negative regulation of response to biotic stimulus 3/1036 47/18670 0.4881 0.8187 0.7229 C1QBP/HTRA1/GPATCH3 3 GO:0008206 bile acid metabolic process 3/1036 47/18670 0.4881 0.8187 0.7229 NPC1/SCP2/CH25H 3 GO:0014911 positive regulation of smooth muscle cell migration 3/1036 47/18670 0.4881 0.8187 0.7229 CCL5/LRP1/HDAC4 3 GO:0030574 collagen catabolic process 3/1036 47/18670 0.4881 0.8187 0.7229 ADAMTS2/CTSD/ADAM15 3 GO:0045190 isotype switching 3/1036 47/18670 0.4881 0.8187 0.7229 TNFSF13/MSH2/TBX21 3 GO:0050435 amyloid-beta metabolic process 3/1036 47/18670 0.4881 0.8187 0.7229 IFNG/TNF/DYRK1A 3 GO:0060986 endocrine hormone secretion 3/1036 47/18670 0.4881 0.8187 0.7229 IL1B/GNAS/CRY1 3 GO:0061383 trabecula morphogenesis 3/1036 47/18670 0.4881 0.8187 0.7229 SOS1/TGFBR3/HEG1 3 GO:0061614 pri-miRNA transcription by RNA polymerase II 3/1036 47/18670 0.4881 0.8187 0.7229 HDAC4/SPI1/LILRB4 3 GO:0070169 positive regulation of biomineral tissue development 3/1036 47/18670 0.4881 0.8187 0.7229 ACVR1/BMPR1B/FBXO5 3 GO:0070231 T cell apoptotic process 3/1036 47/18670 0.4881 0.8187 0.7229 CCL5/PRKCQ/CLC 3 GO:0070849 response to epidermal growth factor 3/1036 47/18670 0.4881 0.8187 0.7229 ZFP36/MAPK3/PDE8A 3 GO:1903115 regulation of actin filament-based movement 3/1036 47/18670 0.4881 0.8187 0.7229 ATP2A2/PDE4B/RANGRF 3 GO:0007281 germ cell development 15/1036 262/18670 0.4884 0.8187 0.7229 CEP57/PTX3/AURKC/CDC25B/DLD/DYNLL1/ACVR1/PSME4/BMPR1B/MSH2/RARA/FBXO5/ZBTB16/PLA2G3/UBE2J1 15 GO:0035308 negative regulation of protein dephosphorylation 4/1036 65/18670 0.4901 0.8187 0.7229 PPP1R17/PPP1R16B/PPP1R8/TNF 4 GO:0045739 positive regulation of DNA repair 4/1036 65/18670 0.4901 0.8187 0.7229 PCNA/PARP1/WAS/CBX8 4 GO:0071806 protein transmembrane transport 4/1036 65/18670 0.4901 0.8187 0.7229 TRAM1/AGK/TOMM20/BCR 4 GO:0000018 regulation of DNA recombination 6/1036 101/18670 0.4921 0.8187 0.7229 PARP1/TNFSF13/WAS/MSH2/TBX21/POLQ 6 GO:0002027 regulation of heart rate 6/1036 101/18670 0.4921 0.8187 0.7229 ATP2A2/SCN10A/GPD1L/RANGRF/KCNQ1/NMU 6 GO:0031532 actin cytoskeleton reorganization 6/1036 101/18670 0.4921 0.8187 0.7229 AUTS2/TRPM2/CD2AP/ANXA1/PARVA/HAX1 6 GO:0031644 regulation of neurological system process 8/1036 137/18670 0.4931 0.8187 0.7229 ABAT/CTSC/EIF4A3/NTSR1/GLRA1/CST7/NMU/GRIN2D 8 GO:0003018 vascular process in circulatory system 10/1036 173/18670 0.4937 0.8187 0.7229 CD38/P2RX1/GCLC/CHGA/HRH2/AVPR1B/PIK3C2A/SOD1/BCR/ATG5 10 GO:0051216 cartilage development 12/1036 209/18670 0.494 0.8187 0.7229 TGFBR2/GNAS/BMPR1B/MEX3C/SULF1/RARA/MAPK3/ZBTB16/OTOR/FGF18/SIX2/MAF 12 GO:0030100 regulation of endocytosis 16/1036 281/18670 0.4945 0.8187 0.7229 IFNG/IL2RB/IL1B/PTX3/LDLRAP1/TNF/CD2AP/LRP1/DNM1L/IL15RA/IL15/SOD1/AP2B1/BCR/ATG5/CBLL1 16 GO:0045666 positive regulation of neuron differentiation 21/1036 371/18670 0.4948 0.8187 0.7229 NCK1/ITGA6/CPNE6/FYN/CAPRIN2/CXCR4/PLXNB2/LRP1/DNM1L/RARA/TIMP2/TMEM106B/STK11/DBN1/CAPRIN1/DSCAM/MMD/SETX/NTN1/ADNP/FEZ1 21 GO:0002002 regulation of angiotensin levels in blood 1/1036 12/18670 0.496 0.8187 0.7229 CTSG 1 GO:0002003 angiotensin maturation 1/1036 12/18670 0.496 0.8187 0.7229 CTSG 1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/1036 12/18670 0.496 0.8187 0.7229 TNF 1 GO:0003207 cardiac chamber formation 1/1036 12/18670 0.496 0.8187 0.7229 SMARCD3 1 GO:0003334 keratinocyte development 1/1036 12/18670 0.496 0.8187 0.7229 BCL11B 1 GO:0006068 ethanol catabolic process 1/1036 12/18670 0.496 0.8187 0.7229 ALDH3B1 1 GO:0006216 cytidine catabolic process 1/1036 12/18670 0.496 0.8187 0.7229 APOBEC3G 1 GO:0006465 signal peptide processing 1/1036 12/18670 0.496 0.8187 0.7229 SPCS1 1 GO:0006554 lysine catabolic process 1/1036 12/18670 0.496 0.8187 0.7229 DLD 1 GO:0006563 L-serine metabolic process 1/1036 12/18670 0.496 0.8187 0.7229 CBS 1 GO:0006991 response to sterol depletion 1/1036 12/18670 0.496 0.8187 0.7229 INSIG1 1 GO:0007077 mitotic nuclear envelope disassembly 1/1036 12/18670 0.496 0.8187 0.7229 VRK1 1 GO:0007288 sperm axoneme assembly 1/1036 12/18670 0.496 0.8187 0.7229 PLA2G3 1 GO:0007320 insemination 1/1036 12/18670 0.496 0.8187 0.7229 P2RX1 1 GO:0009086 methionine biosynthetic process 1/1036 12/18670 0.496 0.8187 0.7229 MTR 1 GO:0009642 response to light intensity 1/1036 12/18670 0.496 0.8187 0.7229 CAT 1 GO:0009972 cytidine deamination 1/1036 12/18670 0.496 0.8187 0.7229 APOBEC3G 1 GO:0014889 muscle atrophy 1/1036 12/18670 0.496 0.8187 0.7229 IL15 1 GO:0015697 quaternary ammonium group transport 1/1036 12/18670 0.496 0.8187 0.7229 SLC38A2 1 GO:0015867 ATP transport 1/1036 12/18670 0.496 0.8187 0.7229 SLC25A5 1 GO:0016554 cytidine to uridine editing 1/1036 12/18670 0.496 0.8187 0.7229 APOBEC3G 1 GO:0019755 one-carbon compound transport 1/1036 12/18670 0.496 0.8187 0.7229 RHAG 1 GO:0030002 cellular anion homeostasis 1/1036 12/18670 0.496 0.8187 0.7229 SLC12A5 1 GO:0030208 dermatan sulfate biosynthetic process 1/1036 12/18670 0.496 0.8187 0.7229 CHST12 1 GO:0030259 lipid glycosylation 1/1036 12/18670 0.496 0.8187 0.7229 ABO 1 GO:0030320 cellular monovalent inorganic anion homeostasis 1/1036 12/18670 0.496 0.8187 0.7229 SLC12A5 1 GO:0031126 snoRNA 3'-end processing 1/1036 12/18670 0.496 0.8187 0.7229 FBL 1 GO:0032230 positive regulation of synaptic transmission, GABAergic 1/1036 12/18670 0.496 0.8187 0.7229 CA7 1 GO:0032905 transforming growth factor beta1 production 1/1036 12/18670 0.496 0.8187 0.7229 CD2AP 1 GO:0033197 response to vitamin E 1/1036 12/18670 0.496 0.8187 0.7229 CAT 1 GO:0034372 very-low-density lipoprotein particle remodeling 1/1036 12/18670 0.496 0.8187 0.7229 CETP 1 GO:0035092 sperm chromatin condensation 1/1036 12/18670 0.496 0.8187 0.7229 PSME4 1 GO:0035437 maintenance of protein localization in endoplasmic reticulum 1/1036 12/18670 0.496 0.8187 0.7229 INSIG1 1 GO:0035721 intraciliary retrograde transport 1/1036 12/18670 0.496 0.8187 0.7229 DYNLL1 1 GO:0036005 response to macrophage colony-stimulating factor 1/1036 12/18670 0.496 0.8187 0.7229 DOK1 1 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 1/1036 12/18670 0.496 0.8187 0.7229 DOK1 1 GO:0038110 interleukin-2-mediated signaling pathway 1/1036 12/18670 0.496 0.8187 0.7229 IL2RB 1 GO:0043696 dedifferentiation 1/1036 12/18670 0.496 0.8187 0.7229 NCOA3 1 GO:0043697 cell dedifferentiation 1/1036 12/18670 0.496 0.8187 0.7229 NCOA3 1 GO:0043922 negative regulation by host of viral transcription 1/1036 12/18670 0.496 0.8187 0.7229 CCL5 1 GO:0045579 positive regulation of B cell differentiation 1/1036 12/18670 0.496 0.8187 0.7229 XBP1 1 GO:0046087 cytidine metabolic process 1/1036 12/18670 0.496 0.8187 0.7229 APOBEC3G 1 GO:0046520 sphingoid biosynthetic process 1/1036 12/18670 0.496 0.8187 0.7229 SPHK2 1 GO:0051095 regulation of helicase activity 1/1036 12/18670 0.496 0.8187 0.7229 MSH2 1 GO:0051481 negative regulation of cytosolic calcium ion concentration 1/1036 12/18670 0.496 0.8187 0.7229 LRP1 1 GO:0051798 positive regulation of hair follicle development 1/1036 12/18670 0.496 0.8187 0.7229 TNF 1 GO:0052803 imidazole-containing compound metabolic process 1/1036 12/18670 0.496 0.8187 0.7229 TRH 1 GO:0060391 positive regulation of SMAD protein signal transduction 1/1036 12/18670 0.496 0.8187 0.7229 PARP1 1 GO:0060670 branching involved in labyrinthine layer morphogenesis 1/1036 12/18670 0.496 0.8187 0.7229 SPINT1 1 GO:0060707 trophoblast giant cell differentiation 1/1036 12/18670 0.496 0.8187 0.7229 LIF 1 GO:0061450 trophoblast cell migration 1/1036 12/18670 0.496 0.8187 0.7229 C1QBP 1 GO:0070486 leukocyte aggregation 1/1036 12/18670 0.496 0.8187 0.7229 IL1B 1 GO:0070572 positive regulation of neuron projection regeneration 1/1036 12/18670 0.496 0.8187 0.7229 LRP1 1 GO:0070586 cell-cell adhesion involved in gastrulation 1/1036 12/18670 0.496 0.8187 0.7229 MBP 1 GO:0071073 positive regulation of phospholipid biosynthetic process 1/1036 12/18670 0.496 0.8187 0.7229 ACSL3 1 GO:0071107 response to parathyroid hormone 1/1036 12/18670 0.496 0.8187 0.7229 HDAC4 1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 1/1036 12/18670 0.496 0.8187 0.7229 FNTA 1 GO:0071472 cellular response to salt stress 1/1036 12/18670 0.496 0.8187 0.7229 AKR1B1 1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production 1/1036 12/18670 0.496 0.8187 0.7229 IL1B 1 GO:0071712 ER-associated misfolded protein catabolic process 1/1036 12/18670 0.496 0.8187 0.7229 DERL1 1 GO:0071888 macrophage apoptotic process 1/1036 12/18670 0.496 0.8187 0.7229 CCL5 1 GO:0072393 microtubule anchoring at microtubule organizing center 1/1036 12/18670 0.496 0.8187 0.7229 PCM1 1 GO:0072710 response to hydroxyurea 1/1036 12/18670 0.496 0.8187 0.7229 ATRX 1 GO:0086067 AV node cell to bundle of His cell communication 1/1036 12/18670 0.496 0.8187 0.7229 SCN10A 1 GO:0090085 regulation of protein deubiquitination 1/1036 12/18670 0.496 0.8187 0.7229 SART3 1 GO:0090161 Golgi ribbon formation 1/1036 12/18670 0.496 0.8187 0.7229 OPTN 1 GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation 1/1036 12/18670 0.496 0.8187 0.7229 TERF1 1 GO:0090520 sphingolipid mediated signaling pathway 1/1036 12/18670 0.496 0.8187 0.7229 SPHK2 1 GO:0098974 postsynaptic actin cytoskeleton organization 1/1036 12/18670 0.496 0.8187 0.7229 DBN1 1 GO:0099550 trans-synaptic signaling, modulating synaptic transmission 1/1036 12/18670 0.496 0.8187 0.7229 EFNB3 1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 1/1036 12/18670 0.496 0.8187 0.7229 ATP2B2 1 GO:0099640 axo-dendritic protein transport 1/1036 12/18670 0.496 0.8187 0.7229 SFPQ 1 GO:1900044 regulation of protein K63-linked ubiquitination 1/1036 12/18670 0.496 0.8187 0.7229 PTPN22 1 GO:1900165 negative regulation of interleukin-6 secretion 1/1036 12/18670 0.496 0.8187 0.7229 PTPN22 1 GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter 1/1036 12/18670 0.496 0.8187 0.7229 NCOR1 1 GO:1901163 regulation of trophoblast cell migration 1/1036 12/18670 0.496 0.8187 0.7229 C1QBP 1 GO:1901387 positive regulation of voltage-gated calcium channel activity 1/1036 12/18670 0.496 0.8187 0.7229 EHD3 1 GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 1/1036 12/18670 0.496 0.8187 0.7229 PLXNB2 1 GO:1902414 protein localization to cell junction 1/1036 12/18670 0.496 0.8187 0.7229 HEG1 1 GO:1902510 regulation of apoptotic DNA fragmentation 1/1036 12/18670 0.496 0.8187 0.7229 IL6 1 GO:1902916 positive regulation of protein polyubiquitination 1/1036 12/18670 0.496 0.8187 0.7229 PTPN22 1 GO:1902950 regulation of dendritic spine maintenance 1/1036 12/18670 0.496 0.8187 0.7229 FYN 1 GO:1904181 positive regulation of membrane depolarization 1/1036 12/18670 0.496 0.8187 0.7229 PARP1 1 GO:1904424 regulation of GTP binding 1/1036 12/18670 0.496 0.8187 0.7229 ARHGEF7 1 GO:1904862 inhibitory synapse assembly 1/1036 12/18670 0.496 0.8187 0.7229 GABRB2 1 GO:1905522 negative regulation of macrophage migration 1/1036 12/18670 0.496 0.8187 0.7229 SLAMF8 1 GO:2000121 regulation of removal of superoxide radicals 1/1036 12/18670 0.496 0.8187 0.7229 TNF 1 GO:2000344 positive regulation of acrosome reaction 1/1036 12/18670 0.496 0.8187 0.7229 GLRA1 1 GO:0001505 regulation of neurotransmitter levels 20/1036 354/18670 0.5 0.8203 0.7243 ABAT/IFNG/IL1B/SLC25A32/PTX3/RORA/ATP2A2/KMO/P2RX1/SLC38A1/NTSR1/TNF/SV2A/DNM1L/TRH/CHRM2/TLR6/GAD2/KHSRP/SLC1A3 20 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6/1036 102/18670 0.5017 0.8203 0.7243 CCNG1/CDK5RAP1/PSMD10/PKMYT1/CCNC/IPO7 6 GO:0001823 mesonephros development 6/1036 102/18670 0.5017 0.8203 0.7243 MYC/CAT/MAGED1/RARA/ZBTB16/SIX2 6 GO:0015837 amine transport 6/1036 102/18670 0.5017 0.8203 0.7243 ABAT/KMO/CHGA/NTSR1/SV2A/TRH 6 GO:0000002 mitochondrial genome maintenance 2/1036 30/18670 0.5019 0.8203 0.7243 PARP1/FLCN 2 GO:0000038 very long-chain fatty acid metabolic process 2/1036 30/18670 0.5019 0.8203 0.7243 ABCD3/CYP4F12 2 GO:0006517 protein deglycosylation 2/1036 30/18670 0.5019 0.8203 0.7243 EDEM1/MAN1A1 2 GO:0021696 cerebellar cortex morphogenesis 2/1036 30/18670 0.5019 0.8203 0.7243 RORA/HERC1 2 GO:0032728 positive regulation of interferon-beta production 2/1036 30/18670 0.5019 0.8203 0.7243 TLR3/POLR3C 2 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter 2/1036 30/18670 0.5019 0.8203 0.7243 CTR9/ZMYND11 2 GO:0046596 regulation of viral entry into host cell 2/1036 30/18670 0.5019 0.8203 0.7243 PTX3/FCN1 2 GO:0048873 homeostasis of number of cells within a tissue 2/1036 30/18670 0.5019 0.8203 0.7243 LIPA/FH 2 GO:0090314 positive regulation of protein targeting to membrane 2/1036 30/18670 0.5019 0.8203 0.7243 FYN/MFF 2 GO:0097421 liver regeneration 2/1036 30/18670 0.5019 0.8203 0.7243 PCNA/CSNK2A2 2 GO:1904837 beta-catenin-TCF complex assembly 2/1036 30/18670 0.5019 0.8203 0.7243 MYC/DACT1 2 GO:1905144 response to acetylcholine 2/1036 30/18670 0.5019 0.8203 0.7243 CHRM5/CHRM2 2 GO:1905145 cellular response to acetylcholine 2/1036 30/18670 0.5019 0.8203 0.7243 CHRM5/CHRM2 2 GO:0000245 spliceosomal complex assembly 5/1036 84/18670 0.502 0.8203 0.7243 SRSF10/SNRPD1/DDX1/SNRPD2/SETX 5 GO:0006368 transcription elongation from RNA polymerase II promoter 5/1036 84/18670 0.502 0.8203 0.7243 CTR9/TCEA1/GTF2H3/MLLT3/ZMYND11 5 GO:0050818 regulation of coagulation 5/1036 84/18670 0.502 0.8203 0.7243 ABAT/ENPP4/PRKCQ/F12/CD9 5 GO:1902803 regulation of synaptic vesicle transport 5/1036 84/18670 0.502 0.8203 0.7243 ATP2A2/P2RX1/MAP2/DNM1L/CHRM2 5 GO:0046626 regulation of insulin receptor signaling pathway 4/1036 66/18670 0.5022 0.8203 0.7243 IL1B/NCK1/PRKCQ/PIK3R1 4 GO:0046888 negative regulation of hormone secretion 4/1036 66/18670 0.5022 0.8203 0.7243 IL1B/CHGA/CRY1/LIF 4 GO:0048207 vesicle targeting, rough ER to cis-Golgi 4/1036 66/18670 0.5022 0.8203 0.7243 CTSC/SCFD1/SEC24A/TMED2 4 GO:0048208 COPII vesicle coating 4/1036 66/18670 0.5022 0.8203 0.7243 CTSC/SCFD1/SEC24A/TMED2 4 GO:0051785 positive regulation of nuclear division 4/1036 66/18670 0.5022 0.8203 0.7243 IL1A/IL1B/ANAPC5/PHB2 4 GO:0008038 neuron recognition 3/1036 48/18670 0.5023 0.8203 0.7243 CXCR4/DSCAM/EFNB3 3 GO:0008089 anterograde axonal transport 3/1036 48/18670 0.5023 0.8203 0.7243 MAP2/SOD1/FEZ1 3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 3/1036 48/18670 0.5023 0.8203 0.7243 KIFAP3/PCDHB13/PCDHB6 3 GO:0030865 cortical cytoskeleton organization 3/1036 48/18670 0.5023 0.8203 0.7243 TNF/WAS/EHD2 3 GO:0035272 exocrine system development 3/1036 48/18670 0.5023 0.8203 0.7243 TNF/XBP1/IGSF3 3 GO:0055010 ventricular cardiac muscle tissue morphogenesis 3/1036 48/18670 0.5023 0.8203 0.7243 TNNI1/TGFBR3/HEG1 3 GO:1903727 positive regulation of phospholipid metabolic process 3/1036 48/18670 0.5023 0.8203 0.7243 ATG14/DGKZ/ACSL3 3 GO:0010769 regulation of cell morphogenesis involved in differentiation 17/1036 301/18670 0.5059 0.8203 0.7243 C1QBP/ARHGAP4/CAPRIN2/PLXNB2/MAP2/LRP1/SEMA4G/DNM1L/ARHGEF7/SEMA3G/STK11/DBN1/CAPRIN1/DSCAM/NTN1/ADNP/EFNB3 17 GO:0007018 microtubule-based movement 16/1036 283/18670 0.5061 0.8203 0.7243 KIF2A/SFPQ/IFT22/DYNLL1/HSPB11/KIFAP3/MAP2/RASGRP1/UXT/FYCO1/PCM1/KIFC3/IGBP1/UBB/SOD1/FEZ1 16 GO:0032409 regulation of transporter activity 16/1036 283/18670 0.5061 0.8203 0.7243 ABCB1/IFNG/CLIC2/CAPN1/NTSR1/PDE4B/PHB2/GPD1L/ATP1B1/SPHK2/JPH3/PON1/CACNB4/RANGRF/KCNS1/EHD3 16 GO:0002377 immunoglobulin production 11/1036 193/18670 0.5079 0.8203 0.7243 TRDV3/ITM2A/IL6/POU2F2/TNFSF13/HLA-DQB1/TNF/MSH2/TBX21/XBP1/POLQ 11 GO:0120032 regulation of plasma membrane bounded cell projection assembly 10/1036 175/18670 0.5084 0.8203 0.7243 AUTS2/PPP1R16B/ATMIN/DYNLL1/VDAC3/TRPM2/WAS/HDAC4/ZMYND10/ATG5 10 GO:0019827 stem cell population maintenance 9/1036 157/18670 0.509 0.8203 0.7243 LBH/CTR9/NCOA3/ELAVL1/LIF/PCM1/ZNF706/SPI1/SIX2 9 GO:0030509 BMP signaling pathway 9/1036 157/18670 0.509 0.8203 0.7243 FKBP8/USP9Y/HTRA1/ACVR1/TGFBR3/BMPR1B/SULF1/MAPK3/AMHR2 9 GO:0031570 DNA integrity checkpoint 9/1036 157/18670 0.509 0.8203 0.7243 PCNA/NAE1/TOPBP1/BTG2/CRY1/MSH2/ATR/WAC/DONSON 9 GO:0030968 endoplasmic reticulum unfolded protein response 7/1036 121/18670 0.5104 0.8203 0.7243 NCK1/DERL1/ATF3/XBP1/EDEM1/PIK3R1/GFPT1 7 GO:0044264 cellular polysaccharide metabolic process 6/1036 103/18670 0.5113 0.8203 0.7243 DYRK2/PASK/UGP2/PPP1CC/PHKG1/B3GNT2 6 GO:0009798 axis specification 5/1036 85/18670 0.5125 0.8203 0.7243 HSPB11/CITED2/PGAP1/SIX2/TMED2 5 GO:0034308 primary alcohol metabolic process 5/1036 85/18670 0.5125 0.8203 0.7243 AKR7A2/AKR1B1/AKR1C3/ALDH3B1/RDH16 5 GO:0009743 response to carbohydrate 13/1036 230/18670 0.5135 0.8203 0.7243 TRA2B/TGFBR2/IL1B/OXCT1/CAT/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/TRH/GHRHR/ADNP 13 GO:0015807 L-amino acid transport 4/1036 67/18670 0.5141 0.8203 0.7243 SLC38A1/NTSR1/SLC7A5/SLC1A3 4 GO:0019748 secondary metabolic process 4/1036 67/18670 0.5141 0.8203 0.7243 AKR7A2/AKR1B1/CBS/AKR1C3 4 GO:0022412 cellular process involved in reproduction in multicellular organism 20/1036 357/18670 0.5155 0.8203 0.7243 MYBL1/FOLR3/SOS1/CEP57/PTX3/AURKC/CDC25B/DLD/DYNLL1/ACVR1/PSME4/BMPR1B/MSH2/RARA/CD9/FBXO5/ZBTB16/UBB/PLA2G3/UBE2J1 20 GO:0002534 cytokine production involved in inflammatory response 3/1036 49/18670 0.5162 0.8203 0.7243 CD96/TLR6/IL17B 3 GO:0002704 negative regulation of leukocyte mediated immunity 3/1036 49/18670 0.5162 0.8203 0.7243 CD96/TBX21/BCR 3 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 3/1036 49/18670 0.5162 0.8203 0.7243 HSD11B2/AVPR1B/CTSG 3 GO:0035094 response to nicotine 3/1036 49/18670 0.5162 0.8203 0.7243 ABAT/NFKB1/TNF 3 GO:0071825 protein-lipid complex subunit organization 3/1036 49/18670 0.5162 0.8203 0.7243 CETP/PRKACB/ACSL3 3 GO:1903018 regulation of glycoprotein metabolic process 3/1036 49/18670 0.5162 0.8203 0.7243 ITM2A/PTX3/IL15 3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3/1036 49/18670 0.5162 0.8203 0.7243 ATF3/BMPR1B/PMAIP1 3 GO:0016049 cell growth 27/1036 484/18670 0.5174 0.8203 0.7243 CD38/AUTS2/TGFBR2/FLCN/ITGA4/WFDC1/PRKCQ/ARHGAP4/CPNE6/CAPRIN2/CXCR4/MEX3C/MAP2/LRP1/SEMA4G/CYFIP2/SPHK2/SEMA3G/STK11/DBN1/RBBP7/PSMD10/DSCAM/NTN1/ADAM15/ADNP/RPS6KA3 27 GO:0019730 antimicrobial humoral response 7/1036 122/18670 0.5192 0.8203 0.7243 CXCL11/LYZ/HMGN2/CHGA/ELANE/CTSG/PGLYRP4 7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7/1036 122/18670 0.5192 0.8203 0.7243 RCHY1/GCLC/RBX1/TRIB2/PSMD10/WAC/RPL11 7 GO:0003299 muscle hypertrophy in response to stress 2/1036 31/18670 0.5195 0.8203 0.7243 ATP2A2/HDAC4 2 GO:0006482 protein demethylation 2/1036 31/18670 0.5195 0.8203 0.7243 KDM5C/KDM5D 2 GO:0006691 leukotriene metabolic process 2/1036 31/18670 0.5195 0.8203 0.7243 CYP4A11/CYP4F12 2 GO:0008214 protein dealkylation 2/1036 31/18670 0.5195 0.8203 0.7243 KDM5C/KDM5D 2 GO:0010762 regulation of fibroblast migration 2/1036 31/18670 0.5195 0.8203 0.7243 ARHGAP4/ARHGEF7 2 GO:0014887 cardiac muscle adaptation 2/1036 31/18670 0.5195 0.8203 0.7243 ATP2A2/HDAC4 2 GO:0014898 cardiac muscle hypertrophy in response to stress 2/1036 31/18670 0.5195 0.8203 0.7243 ATP2A2/HDAC4 2 GO:0019098 reproductive behavior 2/1036 31/18670 0.5195 0.8203 0.7243 UBE2Q1/HDAC4 2 GO:0030431 sleep 2/1036 31/18670 0.5195 0.8203 0.7243 GHRHR/NMU 2 GO:0031338 regulation of vesicle fusion 2/1036 31/18670 0.5195 0.8203 0.7243 ANXA1/TBC1D4 2 GO:0032786 positive regulation of DNA-templated transcription, elongation 2/1036 31/18670 0.5195 0.8203 0.7243 CTR9/HMGN1 2 GO:0034661 ncRNA catabolic process 2/1036 31/18670 0.5195 0.8203 0.7243 DROSHA/EXOSC8 2 GO:0040020 regulation of meiotic nuclear division 2/1036 31/18670 0.5195 0.8203 0.7243 LIF/FBXO5 2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 2/1036 31/18670 0.5195 0.8203 0.7243 SOS1/DOK1 2 GO:0045879 negative regulation of smoothened signaling pathway 2/1036 31/18670 0.5195 0.8203 0.7243 PRKACB/CD3E 2 GO:0048710 regulation of astrocyte differentiation 2/1036 31/18670 0.5195 0.8203 0.7243 IL6/LIF 2 GO:0050849 negative regulation of calcium-mediated signaling 2/1036 31/18670 0.5195 0.8203 0.7243 DYRK2/CLIC2 2 GO:0086011 membrane repolarization during action potential 2/1036 31/18670 0.5195 0.8203 0.7243 ATP1B1/KCNQ1 2 GO:2000406 positive regulation of T cell migration 2/1036 31/18670 0.5195 0.8203 0.7243 CCL5/ITGA4 2 GO:2000781 positive regulation of double-strand break repair 2/1036 31/18670 0.5195 0.8203 0.7243 PARP1/WAS 2 GO:0010959 regulation of metal ion transport 22/1036 394/18670 0.5196 0.8203 0.7243 CXCL11/CCL5/IFNG/P2RX5/CLIC2/P2RX1/FYN/NTSR1/PDE4B/CXCR4/BEST1/GPD1L/ATP1B1/SPHK2/JPH3/CACNB4/RANGRF/TSPAN13/KCNS1/EHD3/KCNQ1/ATG5 22 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 6/1036 104/18670 0.5209 0.8203 0.7243 DYRK2/MOAP1/TNF/MSH2/PIAS4/PIK3R1 6 GO:0046822 regulation of nucleocytoplasmic transport 6/1036 104/18670 0.5209 0.8203 0.7243 IFNG/IL1B/PPP1CC/RIOK2/PIK3R1/NUP214 6 GO:0003333 amino acid transmembrane transport 5/1036 86/18670 0.523 0.8203 0.7243 SLC38A1/NTSR1/SLC7A5/SLC38A2/SLC1A3 5 GO:0006303 double-strand break repair via nonhomologous end joining 5/1036 86/18670 0.523 0.8203 0.7243 PSMD14/PIAS4/HERC2/ZBTB7A/POLQ 5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 5/1036 86/18670 0.523 0.8203 0.7243 KIF2A/SCFD1/KIFAP3/ERGIC2/TMED2 5 GO:0070542 response to fatty acid 5/1036 86/18670 0.523 0.8203 0.7243 CAT/TGFBR3/PON1/PTGER4/AKR1C3 5 GO:0060491 regulation of cell projection assembly 10/1036 177/18670 0.523 0.8203 0.7243 AUTS2/PPP1R16B/ATMIN/DYNLL1/VDAC3/TRPM2/WAS/HDAC4/ZMYND10/ATG5 10 GO:0001833 inner cell mass cell proliferation 1/1036 13/18670 0.524 0.8203 0.7243 NCAPG2 1 GO:0001867 complement activation, lectin pathway 1/1036 13/18670 0.524 0.8203 0.7243 FCN1 1 GO:0001886 endothelial cell morphogenesis 1/1036 13/18670 0.524 0.8203 0.7243 HEG1 1 GO:0001967 suckling behavior 1/1036 13/18670 0.524 0.8203 0.7243 UBE2Q1 1 GO:0002093 auditory receptor cell morphogenesis 1/1036 13/18670 0.524 0.8203 0.7243 SOD1 1 GO:0002281 macrophage activation involved in immune response 1/1036 13/18670 0.524 0.8203 0.7243 LBP 1 GO:0003084 positive regulation of systemic arterial blood pressure 1/1036 13/18670 0.524 0.8203 0.7243 HSD11B2 1 GO:0003157 endocardium development 1/1036 13/18670 0.524 0.8203 0.7243 ACVR1 1 GO:0006596 polyamine biosynthetic process 1/1036 13/18670 0.524 0.8203 0.7243 ODC1 1 GO:0006670 sphingosine metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 SPHK2 1 GO:0006995 cellular response to nitrogen starvation 1/1036 13/18670 0.524 0.8203 0.7243 ATG5 1 GO:0007183 SMAD protein complex assembly 1/1036 13/18670 0.524 0.8203 0.7243 PARP1 1 GO:0007494 midgut development 1/1036 13/18670 0.524 0.8203 0.7243 OTC 1 GO:0008298 intracellular mRNA localization 1/1036 13/18670 0.524 0.8203 0.7243 ZFP36 1 GO:0009162 deoxyribonucleoside monophosphate metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 DCK 1 GO:0009437 carnitine metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 ACADM 1 GO:0009635 response to herbicide 1/1036 13/18670 0.524 0.8203 0.7243 DAXX 1 GO:0009650 UV protection 1/1036 13/18670 0.524 0.8203 0.7243 CAT 1 GO:0010454 negative regulation of cell fate commitment 1/1036 13/18670 0.524 0.8203 0.7243 TBX21 1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 1/1036 13/18670 0.524 0.8203 0.7243 LRP1 1 GO:0010745 negative regulation of macrophage derived foam cell differentiation 1/1036 13/18670 0.524 0.8203 0.7243 CETP 1 GO:0010763 positive regulation of fibroblast migration 1/1036 13/18670 0.524 0.8203 0.7243 ARHGEF7 1 GO:0010870 positive regulation of receptor biosynthetic process 1/1036 13/18670 0.524 0.8203 0.7243 IFNG 1 GO:0016024 CDP-diacylglycerol biosynthetic process 1/1036 13/18670 0.524 0.8203 0.7243 AGPAT2 1 GO:0019896 axonal transport of mitochondrion 1/1036 13/18670 0.524 0.8203 0.7243 FEZ1 1 GO:0021520 spinal cord motor neuron cell fate specification 1/1036 13/18670 0.524 0.8203 0.7243 LHX3 1 GO:0021978 telencephalon regionalization 1/1036 13/18670 0.524 0.8203 0.7243 TRA2B 1 GO:0021984 adenohypophysis development 1/1036 13/18670 0.524 0.8203 0.7243 GHRHR 1 GO:0030007 cellular potassium ion homeostasis 1/1036 13/18670 0.524 0.8203 0.7243 ATP1B1 1 GO:0030205 dermatan sulfate metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 CHST12 1 GO:0031223 auditory behavior 1/1036 13/18670 0.524 0.8203 0.7243 SLC1A3 1 GO:0032754 positive regulation of interleukin-5 production 1/1036 13/18670 0.524 0.8203 0.7243 RARA 1 GO:0033623 regulation of integrin activation 1/1036 13/18670 0.524 0.8203 0.7243 PTGER4 1 GO:0034374 low-density lipoprotein particle remodeling 1/1036 13/18670 0.524 0.8203 0.7243 CETP 1 GO:0034397 telomere localization 1/1036 13/18670 0.524 0.8203 0.7243 TERF1 1 GO:0035563 positive regulation of chromatin binding 1/1036 13/18670 0.524 0.8203 0.7243 GMNN 1 GO:0035627 ceramide transport 1/1036 13/18670 0.524 0.8203 0.7243 ABCB1 1 GO:0036109 alpha-linolenic acid metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 SCP2 1 GO:0042178 xenobiotic catabolic process 1/1036 13/18670 0.524 0.8203 0.7243 CRYZ 1 GO:0042415 norepinephrine metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 AKR1B1 1 GO:0042538 hyperosmotic salinity response 1/1036 13/18670 0.524 0.8203 0.7243 AKR1B1 1 GO:0042635 positive regulation of hair cycle 1/1036 13/18670 0.524 0.8203 0.7243 TNF 1 GO:0043201 response to leucine 1/1036 13/18670 0.524 0.8203 0.7243 SESN1 1 GO:0043301 negative regulation of leukocyte degranulation 1/1036 13/18670 0.524 0.8203 0.7243 BCR 1 GO:0043562 cellular response to nitrogen levels 1/1036 13/18670 0.524 0.8203 0.7243 ATG5 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 1/1036 13/18670 0.524 0.8203 0.7243 GHRHR 1 GO:0043970 histone H3-K9 acetylation 1/1036 13/18670 0.524 0.8203 0.7243 SPHK2 1 GO:0045006 DNA deamination 1/1036 13/18670 0.524 0.8203 0.7243 APOBEC3G 1 GO:0045820 negative regulation of glycolytic process 1/1036 13/18670 0.524 0.8203 0.7243 HDAC4 1 GO:0046040 IMP metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 ADSL 1 GO:0046415 urate metabolic process 1/1036 13/18670 0.524 0.8203 0.7243 PRPS1 1 GO:0046831 regulation of RNA export from nucleus 1/1036 13/18670 0.524 0.8203 0.7243 RIOK2 1 GO:0047484 regulation of response to osmotic stress 1/1036 13/18670 0.524 0.8203 0.7243 ABCB1 1 GO:0048711 positive regulation of astrocyte differentiation 1/1036 13/18670 0.524 0.8203 0.7243 LIF 1 GO:0048715 negative regulation of oligodendrocyte differentiation 1/1036 13/18670 0.524 0.8203 0.7243 DAAM2 1 GO:0048875 chemical homeostasis within a tissue 1/1036 13/18670 0.524 0.8203 0.7243 RCN3 1 GO:0050722 regulation of interleukin-1 beta biosynthetic process 1/1036 13/18670 0.524 0.8203 0.7243 IFNG 1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore 1/1036 13/18670 0.524 0.8203 0.7243 NDC80 1 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1/1036 13/18670 0.524 0.8203 0.7243 CYFIP2 1 GO:0051451 myoblast migration 1/1036 13/18670 0.524 0.8203 0.7243 ANXA1 1 GO:0060123 regulation of growth hormone secretion 1/1036 13/18670 0.524 0.8203 0.7243 GHRHR 1 GO:0060312 regulation of blood vessel remodeling 1/1036 13/18670 0.524 0.8203 0.7243 BCR 1 GO:0060347 heart trabecula formation 1/1036 13/18670 0.524 0.8203 0.7243 TGFBR3 1 GO:0060601 lateral sprouting from an epithelium 1/1036 13/18670 0.524 0.8203 0.7243 SULF1 1 GO:0060712 spongiotrophoblast layer development 1/1036 13/18670 0.524 0.8203 0.7243 LIF 1 GO:0061029 eyelid development in camera-type eye 1/1036 13/18670 0.524 0.8203 0.7243 SOS1 1 GO:0061478 response to platelet aggregation inhibitor 1/1036 13/18670 0.524 0.8203 0.7243 FDX1 1 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 1/1036 13/18670 0.524 0.8203 0.7243 PTPN22 1 GO:0070831 basement membrane assembly 1/1036 13/18670 0.524 0.8203 0.7243 CLASP1 1 GO:0071027 nuclear RNA surveillance 1/1036 13/18670 0.524 0.8203 0.7243 EXOSC8 1 GO:0071028 nuclear mRNA surveillance 1/1036 13/18670 0.524 0.8203 0.7243 EXOSC8 1 GO:0071352 cellular response to interleukin-2 1/1036 13/18670 0.524 0.8203 0.7243 IL2RB 1 GO:0071415 cellular response to purine-containing compound 1/1036 13/18670 0.524 0.8203 0.7243 TRPM2 1 GO:0072044 collecting duct development 1/1036 13/18670 0.524 0.8203 0.7243 AKR1B1 1 GO:0072182 regulation of nephron tubule epithelial cell differentiation 1/1036 13/18670 0.524 0.8203 0.7243 LIF 1 GO:0072672 neutrophil extravasation 1/1036 13/18670 0.524 0.8203 0.7243 CD99 1 GO:0090179 planar cell polarity pathway involved in neural tube closure 1/1036 13/18670 0.524 0.8203 0.7243 FZD2 1 GO:0090399 replicative senescence 1/1036 13/18670 0.524 0.8203 0.7243 ATR 1 GO:0090594 inflammatory response to wounding 1/1036 13/18670 0.524 0.8203 0.7243 IL1A 1 GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/1036 13/18670 0.524 0.8203 0.7243 IARS2 1 GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/1036 13/18670 0.524 0.8203 0.7243 NOL11 1 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 1/1036 13/18670 0.524 0.8203 0.7243 PLXNB2 1 GO:1902947 regulation of tau-protein kinase activity 1/1036 13/18670 0.524 0.8203 0.7243 IFNG 1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1/1036 13/18670 0.524 0.8203 0.7243 LIF 1 GO:1903651 positive regulation of cytoplasmic transport 1/1036 13/18670 0.524 0.8203 0.7243 MAP2 1 GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/1036 13/18670 0.524 0.8203 0.7243 OPTN 1 GO:1990403 embryonic brain development 1/1036 13/18670 0.524 0.8203 0.7243 TRA2B 1 GO:2000009 negative regulation of protein localization to cell surface 1/1036 13/18670 0.524 0.8203 0.7243 LEPROTL1 1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1/1036 13/18670 0.524 0.8203 0.7243 MLLT3 1 GO:0022898 regulation of transmembrane transporter activity 15/1036 268/18670 0.5243 0.8204 0.7244 ABCB1/IFNG/CLIC2/CAPN1/NTSR1/PDE4B/PHB2/GPD1L/ATP1B1/SPHK2/JPH3/CACNB4/RANGRF/KCNS1/EHD3 15 GO:0098727 maintenance of cell number 9/1036 159/18670 0.5244 0.8204 0.7244 LBH/CTR9/NCOA3/ELAVL1/LIF/PCM1/ZNF706/SPI1/SIX2 9 GO:0010951 negative regulation of endopeptidase activity 14/1036 250/18670 0.5253 0.8212 0.7252 WFDC1/LAMP3/MICAL1/BIRC3/SIAH2/RECK/SPINT1/PEBP1/CST7/TIMP2/TIMP4/CSN2/IGBP1/RPS6KA3 14 GO:0006625 protein targeting to peroxisome 4/1036 68/18670 0.5259 0.8212 0.7252 CAT/UBA52/SCP2/UBB 4 GO:0010812 negative regulation of cell-substrate adhesion 4/1036 68/18670 0.5259 0.8212 0.7252 RASA1/LRP1/ADAM15/PIK3R1 4 GO:0033627 cell adhesion mediated by integrin 4/1036 68/18670 0.5259 0.8212 0.7252 CCL5/ITGA4/ITGB4/CD3E 4 GO:0072662 protein localization to peroxisome 4/1036 68/18670 0.5259 0.8212 0.7252 CAT/UBA52/SCP2/UBB 4 GO:0072663 establishment of protein localization to peroxisome 4/1036 68/18670 0.5259 0.8212 0.7252 CAT/UBA52/SCP2/UBB 4 GO:0050709 negative regulation of protein secretion 8/1036 141/18670 0.526 0.8212 0.7252 IL1B/CHGA/TNF/PTPN22/ANXA1/RSAD2/PTGER4/TLR6 8 GO:0051928 positive regulation of calcium ion transport 7/1036 123/18670 0.5279 0.824 0.7276 CXCL11/CCL5/P2RX5/NTSR1/ATP1B1/SPHK2/EHD3 7 GO:0001763 morphogenesis of a branching structure 11/1036 196/18670 0.5288 0.8251 0.7286 MYC/TGFBR2/MAGED1/ACVR1/TNF/PHB2/SPINT1/SULF1/RBM15/CCL11/SIX2 11 GO:0001706 endoderm formation 3/1036 50/18670 0.53 0.8251 0.7286 CTR9/ITGA4/ITGA7 3 GO:0009409 response to cold 3/1036 50/18670 0.53 0.8251 0.7286 TMEM135/TRH/ZNF516 3 GO:0009948 anterior/posterior axis specification 3/1036 50/18670 0.53 0.8251 0.7286 PGAP1/SIX2/TMED2 3 GO:0032784 regulation of DNA-templated transcription, elongation 3/1036 50/18670 0.53 0.8251 0.7286 CTR9/HMGN1/ZMYND11 3 GO:0046854 phosphatidylinositol phosphorylation 3/1036 50/18670 0.53 0.8251 0.7286 PIK3CA/PIK3C2A/PIK3R1 3 GO:0070534 protein K63-linked ubiquitination 3/1036 50/18670 0.53 0.8251 0.7286 PTPN22/RNF115/RNF4 3 GO:0070085 glycosylation 15/1036 269/18670 0.5302 0.8251 0.7286 ST3GAL5/ALG13/POGLUT1/NPC1/ASGR2/MUC2/ASGR1/IL15/MAN1A1/MGAT2/GALNT10/B3GNT2/ABO/UBE2J1/GFPT1 15 GO:0050821 protein stabilization 10/1036 178/18670 0.5303 0.8251 0.7286 CCT7/CDC37L1/CCT2/TRIM44/RPS7/PHB2/PRKRA/ATP1B1/RPL11/PIK3R1 10 GO:0006641 triglyceride metabolic process 6/1036 105/18670 0.5303 0.8251 0.7286 DDHD2/ATG14/CETP/CAT/INSIG1/LIPE 6 GO:0045185 maintenance of protein location 6/1036 105/18670 0.5303 0.8251 0.7286 SKP1/INSIG1/SUPT7L/SYNE1/DBN1/PSMD10 6 GO:0045017 glycerolipid biosynthetic process 14/1036 251/18670 0.5314 0.8265 0.7298 DDHD2/CPNE6/CSNK2A2/STARD7/CPNE3/PIK3CA/GPD1L/DGKZ/AGPAT2/PIK3C2A/AGK/ACSL3/PGAP1/PIK3R1 14 GO:1904062 regulation of cation transmembrane transport 19/1036 342/18670 0.5318 0.8268 0.7301 CXCL11/IFNG/CLIC2/CAPN1/FYN/NTSR1/PDE4B/PHB2/GPD1L/ATP1B1/SPHK2/JPH3/CACNB4/RANGRF/TSPAN13/KCNS1/EHD3/KCNQ1/ATG5 19 GO:0021915 neural tube development 9/1036 160/18670 0.5321 0.8268 0.7301 FKBP8/DACT1/PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 9 GO:0030203 glycosaminoglycan metabolic process 9/1036 160/18670 0.5321 0.8268 0.7301 NFKB1/SLC35D1/IL1B/CHST12/CHPF2/SGSH/IL15/B3GNT2/PGLYRP4 9 GO:0048477 oogenesis 5/1036 87/18670 0.5334 0.8269 0.7302 PTX3/AURKC/CDC25B/BMPR1B/FBXO5 5 GO:0008037 cell recognition 12/1036 215/18670 0.5341 0.8269 0.7302 FOLR3/CCT7/PRF1/CCT2/CXCR4/CD9/DSCAM/FCN1/PCDHB6/CATSPERG/TRBC1/EFNB3 12 GO:0046467 membrane lipid biosynthetic process 8/1036 142/18670 0.5341 0.8269 0.7302 ST3GAL5/P2RX1/TNF/CERS6/SPHK2/ALDH3B1/AGK/PGAP1 8 GO:0050871 positive regulation of B cell activation 8/1036 142/18670 0.5341 0.8269 0.7302 CD38/IL6/TNFSF13/MSH2/TBX21/XBP1/GPR183/TRBC1 8 GO:0051604 protein maturation 22/1036 397/18670 0.5343 0.8269 0.7302 PARP1/PGK1/ISCA1/NFU1/IL1B/C1QBP/ADAMTS2/PRKACB/LIPT1/PLGRKT/BIRC3/F12/C8B/CYFIP2/METAP2/APH1B/CST7/TASP1/KLK13/CD5L/CTSG/SPCS1 22 GO:1904950 negative regulation of establishment of protein localization 11/1036 197/18670 0.5357 0.8269 0.7302 IL1B/INSIG1/CHGA/TNF/PTPN22/ANXA1/RSAD2/PTGER4/TLR6/TERF1/UBE2J1 11 GO:0001838 embryonic epithelial tube formation 7/1036 124/18670 0.5366 0.8269 0.7302 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0007098 centrosome cycle 7/1036 124/18670 0.5366 0.8269 0.7302 TRIM37/NPM1/HAUS2/UXT/PCM1/CEP76/XRCC2 7 GO:0019751 polyol metabolic process 7/1036 124/18670 0.5366 0.8269 0.7302 CD244/NTSR1/PLCL1/QDPR/PLCB3/SPHK2/AKR1B1 7 GO:0003338 metanephros morphogenesis 2/1036 32/18670 0.5367 0.8269 0.7302 LIF/SIX2 2 GO:0006335 DNA replication-dependent nucleosome assembly 2/1036 32/18670 0.5367 0.8269 0.7302 HAT1/RBBP4 2 GO:0006356 regulation of transcription by RNA polymerase I 2/1036 32/18670 0.5367 0.8269 0.7302 NOL11/TAF1C 2 GO:0006739 NADP metabolic process 2/1036 32/18670 0.5367 0.8269 0.7302 DERA/NNT 2 GO:0008608 attachment of spindle microtubules to kinetochore 2/1036 32/18670 0.5367 0.8269 0.7302 AURKC/NDC80 2 GO:0031297 replication fork processing 2/1036 32/18670 0.5367 0.8269 0.7302 PCNA/ATRX 2 GO:0032228 regulation of synaptic transmission, GABAergic 2/1036 32/18670 0.5367 0.8269 0.7302 PLCL1/CA7 2 GO:0034723 DNA replication-dependent nucleosome organization 2/1036 32/18670 0.5367 0.8269 0.7302 HAT1/RBBP4 2 GO:0035510 DNA dealkylation 2/1036 32/18670 0.5367 0.8269 0.7302 ASCC3/APOBEC3G 2 GO:0042311 vasodilation 2/1036 32/18670 0.5367 0.8269 0.7302 SOD1/ATG5 2 GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 2/1036 32/18670 0.5367 0.8269 0.7302 CHGA/FZD2 2 GO:0045987 positive regulation of smooth muscle contraction 2/1036 32/18670 0.5367 0.8269 0.7302 ABAT/NMU 2 GO:0046949 fatty-acyl-CoA biosynthetic process 2/1036 32/18670 0.5367 0.8269 0.7302 ACSL3/ACAT1 2 GO:0051385 response to mineralocorticoid 2/1036 32/18670 0.5367 0.8269 0.7302 PARP1/TRH 2 GO:0060325 face morphogenesis 2/1036 32/18670 0.5367 0.8269 0.7302 ARID5B/RRAS 2 GO:0065005 protein-lipid complex assembly 2/1036 32/18670 0.5367 0.8269 0.7302 PRKACB/ACSL3 2 GO:0070207 protein homotrimerization 2/1036 32/18670 0.5367 0.8269 0.7302 CD247/OTC 2 GO:0071295 cellular response to vitamin 2/1036 32/18670 0.5367 0.8269 0.7302 IL15/TRIM24 2 GO:1901976 regulation of cell cycle checkpoint 2/1036 32/18670 0.5367 0.8269 0.7302 CRY1/NDC80 2 GO:0008088 axo-dendritic transport 4/1036 69/18670 0.5375 0.8269 0.7302 SFPQ/MAP2/SOD1/FEZ1 4 GO:0043574 peroxisomal transport 4/1036 69/18670 0.5375 0.8269 0.7302 CAT/UBA52/SCP2/UBB 4 GO:0051865 protein autoubiquitination 4/1036 69/18670 0.5375 0.8269 0.7302 TRIM68/TRIM37/RNF115/RNF4 4 GO:0007052 mitotic spindle organization 6/1036 106/18670 0.5397 0.8269 0.7302 KIF2A/AURKC/NDC80/TNKS/CLASP1/PRC1 6 GO:0044774 mitotic DNA integrity checkpoint 6/1036 106/18670 0.5397 0.8269 0.7302 PCNA/NAE1/TOPBP1/BTG2/MSH2/DONSON 6 GO:1904029 regulation of cyclin-dependent protein kinase activity 6/1036 106/18670 0.5397 0.8269 0.7302 CCNG1/CDK5RAP1/PSMD10/PKMYT1/CCNC/IPO7 6 GO:0007162 negative regulation of cell adhesion 16/1036 289/18670 0.5406 0.8269 0.7302 ABAT/RASA1/ERBB3/PTPN22/PLXNB2/ANXA1/ADAMDEC1/LRP1/TBX21/MBP/CD9/DSCAM/CCL25/ADAM15/PIK3R1/CBLL1 16 GO:0000075 cell cycle checkpoint 12/1036 216/18670 0.5407 0.8269 0.7302 PCNA/NAE1/TOPBP1/BTG2/ZWINT/CRY1/PSMG2/MSH2/ATR/NDC80/WAC/DONSON 12 GO:0106106 cold-induced thermogenesis 8/1036 143/18670 0.5422 0.8269 0.7302 FLCN/GNAS/PLCL1/CXCR4/STK11/FH/IL15/ZNF516 8 GO:0120161 regulation of cold-induced thermogenesis 8/1036 143/18670 0.5422 0.8269 0.7302 FLCN/GNAS/PLCL1/CXCR4/STK11/FH/IL15/ZNF516 8 GO:0001954 positive regulation of cell-matrix adhesion 3/1036 51/18670 0.5435 0.8269 0.7302 EMP2/CCL25/CD3E 3 GO:0009994 oocyte differentiation 3/1036 51/18670 0.5435 0.8269 0.7302 AURKC/CDC25B/FBXO5 3 GO:0032007 negative regulation of TOR signaling 3/1036 51/18670 0.5435 0.8269 0.7302 FLCN/SESN1/STK11 3 GO:0022404 molting cycle process 5/1036 88/18670 0.5437 0.8269 0.7302 SOS1/TNF/LRIG1/TGM3/SOX21 5 GO:0022405 hair cycle process 5/1036 88/18670 0.5437 0.8269 0.7302 SOS1/TNF/LRIG1/TGM3/SOX21 5 GO:0042147 retrograde transport, endosome to Golgi 5/1036 88/18670 0.5437 0.8269 0.7302 STX10/RAB9A/VPS51/EHD3/GOSR1 5 GO:0045921 positive regulation of exocytosis 5/1036 88/18670 0.5437 0.8269 0.7302 IFNG/DNM1L/RAB9A/SPHK2/CLASP1 5 GO:0061097 regulation of protein tyrosine kinase activity 5/1036 88/18670 0.5437 0.8269 0.7302 CCL5/CBLB/FYN/ERBB3/NCAPG2 5 GO:0106027 neuron projection organization 5/1036 88/18670 0.5437 0.8269 0.7302 FYN/CAPRIN2/DNM1L/DBN1/CAPRIN1 5 GO:0045861 negative regulation of proteolysis 20/1036 363/18670 0.5463 0.8269 0.7302 USP25/WFDC1/LAMP3/MICAL1/BIRC3/SIAH2/RECK/RPS7/CSNK2A2/SPINT1/PEBP1/CST7/TIMP2/TIMP4/CSN2/IGBP1/WAC/RPL11/RPS6KA3/UBE2J1 20 GO:0050905 neuromuscular process 6/1036 107/18670 0.549 0.8269 0.7302 HERC1/GLRA1/JPH3/GRIN2D/SLC1A3/BCR 6 GO:0006901 vesicle coating 4/1036 70/18670 0.549 0.8269 0.7302 CTSC/SCFD1/SEC24A/TMED2 4 GO:0070988 demethylation 4/1036 70/18670 0.549 0.8269 0.7302 CYP2C9/APOBEC3G/KDM5C/KDM5D 4 GO:0030534 adult behavior 8/1036 144/18670 0.5502 0.8269 0.7302 ABAT/NPC1/NTSR1/PUM1/GLRA1/TRH/GRIN2D/EFNB3 8 GO:0071322 cellular response to carbohydrate stimulus 8/1036 144/18670 0.5502 0.8269 0.7302 TRA2B/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/GHRHR 8 GO:0001771 immunological synapse formation 1/1036 14/18670 0.5505 0.8269 0.7302 PRF1 1 GO:0002834 regulation of response to tumor cell 1/1036 14/18670 0.5505 0.8269 0.7302 IL12B 1 GO:0002837 regulation of immune response to tumor cell 1/1036 14/18670 0.5505 0.8269 0.7302 IL12B 1 GO:0003128 heart field specification 1/1036 14/18670 0.5505 0.8269 0.7302 SMARCD3 1 GO:0003214 cardiac left ventricle morphogenesis 1/1036 14/18670 0.5505 0.8269 0.7302 TGFBR2 1 GO:0006241 CTP biosynthetic process 1/1036 14/18670 0.5505 0.8269 0.7302 UCKL1 1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 1/1036 14/18670 0.5505 0.8269 0.7302 CBLB 1 GO:0007501 mesodermal cell fate specification 1/1036 14/18670 0.5505 0.8269 0.7302 SIX2 1 GO:0009071 serine family amino acid catabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 CBS 1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/1036 14/18670 0.5505 0.8269 0.7302 ATP1B1 1 GO:0010917 negative regulation of mitochondrial membrane potential 1/1036 14/18670 0.5505 0.8269 0.7302 PMAIP1 1 GO:0010989 negative regulation of low-density lipoprotein particle clearance 1/1036 14/18670 0.5505 0.8269 0.7302 KHSRP 1 GO:0018410 C-terminal protein amino acid modification 1/1036 14/18670 0.5505 0.8269 0.7302 ATG5 1 GO:0020027 hemoglobin metabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 CAT 1 GO:0021527 spinal cord association neuron differentiation 1/1036 14/18670 0.5505 0.8269 0.7302 LHX3 1 GO:0032802 low-density lipoprotein particle receptor catabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 AP2B1 1 GO:0034331 cell junction maintenance 1/1036 14/18670 0.5505 0.8269 0.7302 KIFC3 1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 1/1036 14/18670 0.5505 0.8269 0.7302 SLC22A13 1 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1/1036 14/18670 0.5505 0.8269 0.7302 CETP 1 GO:0035020 regulation of Rac protein signal transduction 1/1036 14/18670 0.5505 0.8269 0.7302 AUTS2 1 GO:0035435 phosphate ion transmembrane transport 1/1036 14/18670 0.5505 0.8269 0.7302 SLC20A1 1 GO:0036376 sodium ion export across plasma membrane 1/1036 14/18670 0.5505 0.8269 0.7302 ATP1B1 1 GO:0040034 regulation of development, heterochronic 1/1036 14/18670 0.5505 0.8269 0.7302 HMGN1 1 GO:0042574 retinal metabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 AKR1C3 1 GO:0043144 snoRNA processing 1/1036 14/18670 0.5505 0.8269 0.7302 FBL 1 GO:0045198 establishment of epithelial cell apical/basal polarity 1/1036 14/18670 0.5505 0.8269 0.7302 SH3BP1 1 GO:0045651 positive regulation of macrophage differentiation 1/1036 14/18670 0.5505 0.8269 0.7302 LIF 1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/1036 14/18670 0.5505 0.8269 0.7302 APOBEC3G 1 GO:0046036 CTP metabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 UCKL1 1 GO:0046133 pyrimidine ribonucleoside catabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 APOBEC3G 1 GO:0046341 CDP-diacylglycerol metabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 AGPAT2 1 GO:0046629 gamma-delta T cell activation 1/1036 14/18670 0.5505 0.8269 0.7302 GPR18 1 GO:0050667 homocysteine metabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 CBS 1 GO:0050720 interleukin-1 beta biosynthetic process 1/1036 14/18670 0.5505 0.8269 0.7302 IFNG 1 GO:0050930 induction of positive chemotaxis 1/1036 14/18670 0.5505 0.8269 0.7302 ARTN 1 GO:0051645 Golgi localization 1/1036 14/18670 0.5505 0.8269 0.7302 STK11 1 GO:0051917 regulation of fibrinolysis 1/1036 14/18670 0.5505 0.8269 0.7302 F12 1 GO:0055064 chloride ion homeostasis 1/1036 14/18670 0.5505 0.8269 0.7302 SLC12A5 1 GO:0060009 Sertoli cell development 1/1036 14/18670 0.5505 0.8269 0.7302 ATRX 1 GO:0060049 regulation of protein glycosylation 1/1036 14/18670 0.5505 0.8269 0.7302 IL15 1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1/1036 14/18670 0.5505 0.8269 0.7302 PRKACB 1 GO:0060911 cardiac cell fate commitment 1/1036 14/18670 0.5505 0.8269 0.7302 ACVR1 1 GO:0070234 positive regulation of T cell apoptotic process 1/1036 14/18670 0.5505 0.8269 0.7302 CCL5 1 GO:0070669 response to interleukin-2 1/1036 14/18670 0.5505 0.8269 0.7302 IL2RB 1 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/1036 14/18670 0.5505 0.8269 0.7302 DYRK2 1 GO:0090151 establishment of protein localization to mitochondrial membrane 1/1036 14/18670 0.5505 0.8269 0.7302 AGK 1 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1/1036 14/18670 0.5505 0.8269 0.7302 FZD2 1 GO:0090231 regulation of spindle checkpoint 1/1036 14/18670 0.5505 0.8269 0.7302 NDC80 1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/1036 14/18670 0.5505 0.8269 0.7302 NDC80 1 GO:0097202 activation of cysteine-type endopeptidase activity 1/1036 14/18670 0.5505 0.8269 0.7302 CYFIP2 1 GO:0099171 presynaptic modulation of chemical synaptic transmission 1/1036 14/18670 0.5505 0.8269 0.7302 RPL22 1 GO:0099188 postsynaptic cytoskeleton organization 1/1036 14/18670 0.5505 0.8269 0.7302 DBN1 1 GO:0106057 negative regulation of calcineurin-mediated signaling 1/1036 14/18670 0.5505 0.8269 0.7302 DYRK2 1 GO:1900121 negative regulation of receptor binding 1/1036 14/18670 0.5505 0.8269 0.7302 ADAM15 1 GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 1/1036 14/18670 0.5505 0.8269 0.7302 ACVR1 1 GO:1902570 protein localization to nucleolus 1/1036 14/18670 0.5505 0.8269 0.7302 RRS1 1 GO:1903351 cellular response to dopamine 1/1036 14/18670 0.5505 0.8269 0.7302 MAPK3 1 GO:1903504 regulation of mitotic spindle checkpoint 1/1036 14/18670 0.5505 0.8269 0.7302 NDC80 1 GO:1903624 regulation of DNA catabolic process 1/1036 14/18670 0.5505 0.8269 0.7302 IL6 1 GO:1904263 positive regulation of TORC1 signaling 1/1036 14/18670 0.5505 0.8269 0.7302 FLCN 1 GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 1/1036 14/18670 0.5505 0.8269 0.7302 OPTN 1 GO:1905516 positive regulation of fertilization 1/1036 14/18670 0.5505 0.8269 0.7302 GLRA1 1 GO:2000345 regulation of hepatocyte proliferation 1/1036 14/18670 0.5505 0.8269 0.7302 XBP1 1 GO:2001044 regulation of integrin-mediated signaling pathway 1/1036 14/18670 0.5505 0.8269 0.7302 EMP2 1 GO:2001212 regulation of vasculogenesis 1/1036 14/18670 0.5505 0.8269 0.7302 EMP2 1 GO:0006891 intra-Golgi vesicle-mediated transport 2/1036 33/18670 0.5535 0.8269 0.7302 COG5/GOSR1 2 GO:0010464 regulation of mesenchymal cell proliferation 2/1036 33/18670 0.5535 0.8269 0.7302 MYC/TGFBR2 2 GO:0010837 regulation of keratinocyte proliferation 2/1036 33/18670 0.5535 0.8269 0.7302 ZFP36/BCL11B 2 GO:0019934 cGMP-mediated signaling 2/1036 33/18670 0.5535 0.8269 0.7302 PRKAR2B/ADNP 2 GO:0030513 positive regulation of BMP signaling pathway 2/1036 33/18670 0.5535 0.8269 0.7302 FKBP8/SULF1 2 GO:0031112 positive regulation of microtubule polymerization or depolymerization 2/1036 33/18670 0.5535 0.8269 0.7302 CLASP1/TERF1 2 GO:0040001 establishment of mitotic spindle localization 2/1036 33/18670 0.5535 0.8269 0.7302 NDC80/CLASP1 2 GO:0042755 eating behavior 2/1036 33/18670 0.5535 0.8269 0.7302 TRH/NMU 2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 2/1036 33/18670 0.5535 0.8269 0.7302 CDK5RAP1/IPO7 2 GO:0048011 neurotrophin TRK receptor signaling pathway 2/1036 33/18670 0.5535 0.8269 0.7302 SOS1/CYFIP2 2 GO:0048536 spleen development 2/1036 33/18670 0.5535 0.8269 0.7302 RBM15/CITED2 2 GO:0048821 erythrocyte development 2/1036 33/18670 0.5535 0.8269 0.7302 RHAG/ZBTB7A 2 GO:0051194 positive regulation of cofactor metabolic process 2/1036 33/18670 0.5535 0.8269 0.7302 IFNG/NNT 2 GO:0070232 regulation of T cell apoptotic process 2/1036 33/18670 0.5535 0.8269 0.7302 CCL5/PRKCQ 2 GO:0071985 multivesicular body sorting pathway 2/1036 33/18670 0.5535 0.8269 0.7302 LEPROTL1/VPS37B 2 GO:1901186 positive regulation of ERBB signaling pathway 2/1036 33/18670 0.5535 0.8269 0.7302 SOS1/DOK1 2 GO:2001024 negative regulation of response to drug 2/1036 33/18670 0.5535 0.8269 0.7302 ABAT/PDE8A 2 GO:0032271 regulation of protein polymerization 12/1036 218/18670 0.5537 0.8269 0.7302 NCK1/RASA1/ADD3/WAS/MAP2/RANGRF/CCL11/CLASP1/DBN1/DYRK1A/HAX1/TERF1 12 GO:0032479 regulation of type I interferon production 7/1036 126/18670 0.5538 0.8269 0.7302 NFKB1/PTPN22/POLR3K/TLR3/POLR3C/PQBP1/GPATCH3 7 GO:0048706 embryonic skeletal system development 7/1036 126/18670 0.5538 0.8269 0.7302 SLC35D1/TGFBR2/GNAS/EIF4A3/HOXA6/SULF1/SIX2 7 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 7/1036 126/18670 0.5538 0.8269 0.7302 TGFBR2/HTRA1/ACVR1/TGFBR3/UBA52/UBB/ZBTB7A 7 GO:0006094 gluconeogenesis 5/1036 89/18670 0.5538 0.8269 0.7302 MDH1/PGK1/CRY1/ATF3/CLK2 5 GO:0016485 protein processing 18/1036 328/18670 0.5542 0.8273 0.7305 PARP1/PGK1/IL1B/C1QBP/ADAMTS2/PRKACB/PLGRKT/BIRC3/F12/C8B/CYFIP2/METAP2/APH1B/CST7/KLK13/CD5L/CTSG/SPCS1 18 GO:0016447 somatic recombination of immunoglobulin gene segments 3/1036 52/18670 0.5568 0.83 0.733 TNFSF13/MSH2/TBX21 3 GO:0048168 regulation of neuronal synaptic plasticity 3/1036 52/18670 0.5568 0.83 0.733 SLC8A2/JPH3/DBN1 3 GO:0055078 sodium ion homeostasis 3/1036 52/18670 0.5568 0.83 0.733 ATP1B1/CYP4A11/CYP4F12 3 GO:0072132 mesenchyme morphogenesis 3/1036 52/18670 0.5568 0.83 0.733 MYC/TGFBR2/ACVR1 3 GO:2000649 regulation of sodium ion transmembrane transporter activity 3/1036 52/18670 0.5568 0.83 0.733 GPD1L/ATP1B1/RANGRF 3 GO:0043647 inositol phosphate metabolic process 4/1036 71/18670 0.5604 0.8304 0.7333 CD244/NTSR1/PLCL1/PLCB3 4 GO:0050795 regulation of behavior 4/1036 71/18670 0.5604 0.8304 0.7333 TRH/HDAC4/GHRHR/NMU 4 GO:1904427 positive regulation of calcium ion transmembrane transport 4/1036 71/18670 0.5604 0.8304 0.7333 CXCL11/NTSR1/ATP1B1/EHD3 4 GO:0060271 cilium assembly 20/1036 366/18670 0.5614 0.8304 0.7333 CEP57/ATMIN/IFT22/DYNLL1/VDAC3/HSPB11/KIFAP3/PARVA/PRKAR2B/HAUS2/PCM1/CEP76/ABCC4/CLASP1/ATAT1/ABLIM1/EHD3/ZMYND10/PLA2G3/ATG5 20 GO:0007611 learning or memory 14/1036 256/18670 0.5616 0.8304 0.7333 DDHD2/EIF4A3/BTG2/VDAC3/FYN/NTSR1/SLC12A5/ATP8A1/HRH2/SLC8A2/PRKAR2B/JPH3/CCL11/ADNP 14 GO:0035270 endocrine system development 7/1036 127/18670 0.5623 0.8304 0.7333 ARID5B/IL6/LHX3/ANXA1/MAPK3/CITED2/GHRHR 7 GO:0001656 metanephros development 5/1036 90/18670 0.5639 0.8304 0.7333 MYC/LIF/AKR1B1/SIX2/ACAT1 5 GO:0010717 regulation of epithelial to mesenchymal transition 5/1036 90/18670 0.5639 0.8304 0.7333 IL6/TGFBR2/IL1B/ACVR1/CLASP1 5 GO:0034333 adherens junction assembly 5/1036 90/18670 0.5639 0.8304 0.7333 LRP1/ARHGEF7/ACTN1/CLASP1/BCR 5 GO:1903035 negative regulation of response to wounding 5/1036 90/18670 0.5639 0.8304 0.7333 ABAT/WFDC1/F12/CLASP1/CD9 5 GO:0051384 response to glucocorticoid 8/1036 146/18670 0.5661 0.8304 0.7333 PCNA/IL6/HSD11B2/ZFP36/TNF/ANXA1/TRH/GHRHR 8 GO:0051261 protein depolymerization 6/1036 109/18670 0.5673 0.8304 0.7333 KIF2A/ADD3/MICAL1/CKAP2/CLASP1/SH3BP1 6 GO:0006575 cellular modified amino acid metabolic process 11/1036 202/18670 0.5696 0.8304 0.7333 SLC25A32/OPLAH/PLOD1/GCLC/ACADM/GLO1/AHCY/GSTT2/SOD1/AASDHPPT/GSTA3 11 GO:0007093 mitotic cell cycle checkpoint 9/1036 165/18670 0.5696 0.8304 0.7333 PCNA/NAE1/TOPBP1/BTG2/ZWINT/PSMG2/MSH2/NDC80/DONSON 9 GO:0010043 response to zinc ion 3/1036 53/18670 0.5699 0.8304 0.7333 PARP1/GLRA1/OTC 3 GO:0030195 negative regulation of blood coagulation 3/1036 53/18670 0.5699 0.8304 0.7333 ABAT/F12/CD9 3 GO:0032715 negative regulation of interleukin-6 production 3/1036 53/18670 0.5699 0.8304 0.7333 SLAMF1/TNF/PTPN22 3 GO:0032964 collagen biosynthetic process 3/1036 53/18670 0.5699 0.8304 0.7333 IL6/RCN3/CBX8 3 GO:0038066 p38MAPK cascade 3/1036 53/18670 0.5699 0.8304 0.7333 IL1B/ZFP36/PTPN22 3 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 3/1036 53/18670 0.5699 0.8304 0.7333 CCL5/GPRASP1/CRY1 3 GO:0045851 pH reduction 3/1036 53/18670 0.5699 0.8304 0.7333 CCKBR/CA7/SLAMF8 3 GO:0007094 mitotic spindle assembly checkpoint 2/1036 34/18670 0.5699 0.8304 0.7333 PSMG2/NDC80 2 GO:0010765 positive regulation of sodium ion transport 2/1036 34/18670 0.5699 0.8304 0.7333 GPD1L/ATP1B1 2 GO:0010984 regulation of lipoprotein particle clearance 2/1036 34/18670 0.5699 0.8304 0.7333 LDLRAP1/KHSRP 2 GO:0019228 neuronal action potential 2/1036 34/18670 0.5699 0.8304 0.7333 P2RX1/SCN10A 2 GO:0031577 spindle checkpoint 2/1036 34/18670 0.5699 0.8304 0.7333 PSMG2/NDC80 2 GO:0032594 protein transport within lipid bilayer 2/1036 34/18670 0.5699 0.8304 0.7333 ATP1B1/RFTN1 2 GO:0045920 negative regulation of exocytosis 2/1036 34/18670 0.5699 0.8304 0.7333 ANXA1/BCR 2 GO:0048566 embryonic digestive tract development 2/1036 34/18670 0.5699 0.8304 0.7333 TNF/SIX2 2 GO:0048665 neuron fate specification 2/1036 34/18670 0.5699 0.8304 0.7333 LHX3/TLX3 2 GO:0060795 cell fate commitment involved in formation of primary germ layer 2/1036 34/18670 0.5699 0.8304 0.7333 CTR9/SIX2 2 GO:0070670 response to interleukin-4 2/1036 34/18670 0.5699 0.8304 0.7333 XBP1/CCL11 2 GO:0071173 spindle assembly checkpoint 2/1036 34/18670 0.5699 0.8304 0.7333 PSMG2/NDC80 2 GO:0071174 mitotic spindle checkpoint 2/1036 34/18670 0.5699 0.8304 0.7333 PSMG2/NDC80 2 GO:0098901 regulation of cardiac muscle cell action potential 2/1036 34/18670 0.5699 0.8304 0.7333 ATP2A2/RANGRF 2 GO:0140115 export across plasma membrane 2/1036 34/18670 0.5699 0.8304 0.7333 ATP1B1/KCNQ1 2 GO:1904030 negative regulation of cyclin-dependent protein kinase activity 2/1036 34/18670 0.5699 0.8304 0.7333 CDK5RAP1/IPO7 2 GO:0033002 muscle cell proliferation 13/1036 239/18670 0.5702 0.8304 0.7333 CCL5/IL6/IFNG/TGFBR2/LDLRAP1/IL12B/TNF/TGFBR3/ELANE/HDAC4/AKR1B1/ABCC4/IL15 13 GO:0009855 determination of bilateral symmetry 7/1036 128/18670 0.5707 0.8304 0.7333 AIDA/TGFBR2/DAAM2/ACVR1/BICC1/CITED2/TMED2 7 GO:0032606 type I interferon production 7/1036 128/18670 0.5707 0.8304 0.7333 NFKB1/PTPN22/POLR3K/TLR3/POLR3C/PQBP1/GPATCH3 7 GO:0050805 negative regulation of synaptic transmission 4/1036 72/18670 0.5715 0.8304 0.7333 CD38/IL1B/EIF4A3/ADNP 4 GO:0060193 positive regulation of lipase activity 4/1036 72/18670 0.5715 0.8304 0.7333 CCL5/TXK/ITK/AVPR1B 4 GO:0061180 mammary gland epithelium development 4/1036 72/18670 0.5715 0.8304 0.7333 LBH/PHB2/CCL11/NTN1 4 GO:0048639 positive regulation of developmental growth 10/1036 184/18670 0.573 0.8304 0.7333 TGFBR2/CPNE6/TGFBR3/CXCR4/LRP1/DBN1/GHRHR/DSCAM/NTN1/ADNP 10 GO:0001578 microtubule bundle formation 5/1036 91/18670 0.5738 0.8304 0.7333 MAP2/CLASP1/ZMYND10/PLA2G3/PRC1 5 GO:0048814 regulation of dendrite morphogenesis 5/1036 91/18670 0.5738 0.8304 0.7333 CAPRIN2/DNM1L/STK11/DBN1/CAPRIN1 5 GO:0060333 interferon-gamma-mediated signaling pathway 5/1036 91/18670 0.5738 0.8304 0.7333 HLA-DRB4/IFNG/TRIM68/HLA-DQB1/TXK 5 GO:0001325 formation of extrachromosomal circular DNA 1/1036 15/18670 0.5754 0.8304 0.7333 TERF1 1 GO:0001711 endodermal cell fate commitment 1/1036 15/18670 0.5754 0.8304 0.7333 CTR9 1 GO:0002716 negative regulation of natural killer cell mediated immunity 1/1036 15/18670 0.5754 0.8304 0.7333 CD96 1 GO:0006000 fructose metabolic process 1/1036 15/18670 0.5754 0.8304 0.7333 AKR1B1 1 GO:0006098 pentose-phosphate shunt 1/1036 15/18670 0.5754 0.8304 0.7333 DERA 1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1/1036 15/18670 0.5754 0.8304 0.7333 DDX1 1 GO:0006390 mitochondrial transcription 1/1036 15/18670 0.5754 0.8304 0.7333 TFB2M 1 GO:0006491 N-glycan processing 1/1036 15/18670 0.5754 0.8304 0.7333 MAN1A1 1 GO:0007039 protein catabolic process in the vacuole 1/1036 15/18670 0.5754 0.8304 0.7333 LRP1 1 GO:0007216 G protein-coupled glutamate receptor signaling pathway 1/1036 15/18670 0.5754 0.8304 0.7333 TRPM1 1 GO:0007638 mechanosensory behavior 1/1036 15/18670 0.5754 0.8304 0.7333 SLC1A3 1 GO:0009109 coenzyme catabolic process 1/1036 15/18670 0.5754 0.8304 0.7333 ACAT1 1 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 UCKL1 1 GO:0010561 negative regulation of glycoprotein biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 ITM2A 1 GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/1036 15/18670 0.5754 0.8304 0.7333 HDAC4 1 GO:0018298 protein-chromophore linkage 1/1036 15/18670 0.5754 0.8304 0.7333 CRY1 1 GO:0030238 male sex determination 1/1036 15/18670 0.5754 0.8304 0.7333 SRY 1 GO:0030812 negative regulation of nucleotide catabolic process 1/1036 15/18670 0.5754 0.8304 0.7333 HDAC4 1 GO:0031573 intra-S DNA damage checkpoint 1/1036 15/18670 0.5754 0.8304 0.7333 MSH2 1 GO:0032239 regulation of nucleobase-containing compound transport 1/1036 15/18670 0.5754 0.8304 0.7333 RIOK2 1 GO:0032486 Rap protein signal transduction 1/1036 15/18670 0.5754 0.8304 0.7333 TIMP2 1 GO:0032736 positive regulation of interleukin-13 production 1/1036 15/18670 0.5754 0.8304 0.7333 RARA 1 GO:0033008 positive regulation of mast cell activation involved in immune response 1/1036 15/18670 0.5754 0.8304 0.7333 SPHK2 1 GO:0033151 V(D)J recombination 1/1036 15/18670 0.5754 0.8304 0.7333 BCL11B 1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 1/1036 15/18670 0.5754 0.8304 0.7333 SCP2 1 GO:0034134 toll-like receptor 2 signaling pathway 1/1036 15/18670 0.5754 0.8304 0.7333 TLR6 1 GO:0034349 glial cell apoptotic process 1/1036 15/18670 0.5754 0.8304 0.7333 PRKCH 1 GO:0034380 high-density lipoprotein particle assembly 1/1036 15/18670 0.5754 0.8304 0.7333 PRKACB 1 GO:0035864 response to potassium ion 1/1036 15/18670 0.5754 0.8304 0.7333 SOD1 1 GO:0036159 inner dynein arm assembly 1/1036 15/18670 0.5754 0.8304 0.7333 ZMYND10 1 GO:0042159 lipoprotein catabolic process 1/1036 15/18670 0.5754 0.8304 0.7333 CTSD 1 GO:0042559 pteridine-containing compound biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 QDPR 1 GO:0042921 glucocorticoid receptor signaling pathway 1/1036 15/18670 0.5754 0.8304 0.7333 CRY1 1 GO:0042983 amyloid precursor protein biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 ITM2A 1 GO:0042984 regulation of amyloid precursor protein biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 ITM2A 1 GO:0043249 erythrocyte maturation 1/1036 15/18670 0.5754 0.8304 0.7333 ZBTB7A 1 GO:0043306 positive regulation of mast cell degranulation 1/1036 15/18670 0.5754 0.8304 0.7333 SPHK2 1 GO:0045360 regulation of interleukin-1 biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 IFNG 1 GO:0045475 locomotor rhythm 1/1036 15/18670 0.5754 0.8304 0.7333 NCOR1 1 GO:0045837 negative regulation of membrane potential 1/1036 15/18670 0.5754 0.8304 0.7333 PMAIP1 1 GO:0045838 positive regulation of membrane potential 1/1036 15/18670 0.5754 0.8304 0.7333 NNT 1 GO:0048172 regulation of short-term neuronal synaptic plasticity 1/1036 15/18670 0.5754 0.8304 0.7333 SLC8A2 1 GO:0048368 lateral mesoderm development 1/1036 15/18670 0.5754 0.8304 0.7333 CITED2 1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 CHST12 1 GO:0051127 positive regulation of actin nucleation 1/1036 15/18670 0.5754 0.8304 0.7333 WAS 1 GO:0051198 negative regulation of coenzyme metabolic process 1/1036 15/18670 0.5754 0.8304 0.7333 HDAC4 1 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 1/1036 15/18670 0.5754 0.8304 0.7333 IFNG 1 GO:0055089 fatty acid homeostasis 1/1036 15/18670 0.5754 0.8304 0.7333 XBP1 1 GO:0060579 ventral spinal cord interneuron fate commitment 1/1036 15/18670 0.5754 0.8304 0.7333 LHX3 1 GO:0060581 cell fate commitment involved in pattern specification 1/1036 15/18670 0.5754 0.8304 0.7333 LHX3 1 GO:0060841 venous blood vessel development 1/1036 15/18670 0.5754 0.8304 0.7333 HEG1 1 GO:0070365 hepatocyte differentiation 1/1036 15/18670 0.5754 0.8304 0.7333 ANXA1 1 GO:0071025 RNA surveillance 1/1036 15/18670 0.5754 0.8304 0.7333 EXOSC8 1 GO:0071474 cellular hyperosmotic response 1/1036 15/18670 0.5754 0.8304 0.7333 AKR1B1 1 GO:0071801 regulation of podosome assembly 1/1036 15/18670 0.5754 0.8304 0.7333 TNF 1 GO:0072075 metanephric mesenchyme development 1/1036 15/18670 0.5754 0.8304 0.7333 MYC 1 GO:0072160 nephron tubule epithelial cell differentiation 1/1036 15/18670 0.5754 0.8304 0.7333 LIF 1 GO:0090136 epithelial cell-cell adhesion 1/1036 15/18670 0.5754 0.8304 0.7333 KIFC3 1 GO:0090177 establishment of planar polarity involved in neural tube closure 1/1036 15/18670 0.5754 0.8304 0.7333 FZD2 1 GO:0090656 t-circle formation 1/1036 15/18670 0.5754 0.8304 0.7333 TERF1 1 GO:0090737 telomere maintenance via telomere trimming 1/1036 15/18670 0.5754 0.8304 0.7333 TERF1 1 GO:0098840 protein transport along microtubule 1/1036 15/18670 0.5754 0.8304 0.7333 SFPQ 1 GO:0099118 microtubule-based protein transport 1/1036 15/18670 0.5754 0.8304 0.7333 SFPQ 1 GO:1900037 regulation of cellular response to hypoxia 1/1036 15/18670 0.5754 0.8304 0.7333 CHCHD2 1 GO:1900119 positive regulation of execution phase of apoptosis 1/1036 15/18670 0.5754 0.8304 0.7333 IL6 1 GO:1901841 regulation of high voltage-gated calcium channel activity 1/1036 15/18670 0.5754 0.8304 0.7333 PDE4B 1 GO:1902188 positive regulation of viral release from host cell 1/1036 15/18670 0.5754 0.8304 0.7333 VPS37B 1 GO:1902969 mitotic DNA replication 1/1036 15/18670 0.5754 0.8304 0.7333 MCM6 1 GO:1903350 response to dopamine 1/1036 15/18670 0.5754 0.8304 0.7333 MAPK3 1 GO:1903543 positive regulation of exosomal secretion 1/1036 15/18670 0.5754 0.8304 0.7333 IFNG 1 GO:2001028 positive regulation of endothelial cell chemotaxis 1/1036 15/18670 0.5754 0.8304 0.7333 FGF18 1 GO:0006024 glycosaminoglycan biosynthetic process 6/1036 110/18670 0.5764 0.8313 0.7341 NFKB1/SLC35D1/IL1B/CHST12/CHPF2/B3GNT2 6 GO:0006664 glycolipid metabolic process 6/1036 110/18670 0.5764 0.8313 0.7341 ST3GAL5/CREM/ESYT1/ARSA/PGAP1/CERK 6 GO:0006639 acylglycerol metabolic process 7/1036 129/18670 0.579 0.8344 0.7368 DDHD2/ATG14/CETP/CAT/INSIG1/LIPE/DGKZ 7 GO:0009799 specification of symmetry 7/1036 129/18670 0.579 0.8344 0.7368 AIDA/TGFBR2/DAAM2/ACVR1/BICC1/CITED2/TMED2 7 GO:0050853 B cell receptor signaling pathway 7/1036 129/18670 0.579 0.8344 0.7368 CD38/PRKCH/PTPN22/ITK/LCK/RFTN1/TRBC1 7 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 12/1036 222/18670 0.5794 0.8346 0.737 CCL5/PTX3/LAMP3/ZFP36/TNF/CXCR4/EXOC7/RSAD2/PABPC1/APOBEC3G/VPS37B/FCN1 12 GO:0003007 heart morphogenesis 14/1036 259/18670 0.5794 0.8346 0.737 SOS1/TGFBR2/ACVR1/TNNI1/TGFBR3/SMARCD3/PARVA/RARA/RBM15/CITED2/HEG1/ADAM15/FZD2/TMED2 14 GO:0002792 negative regulation of peptide secretion 8/1036 148/18670 0.5816 0.8358 0.738 IL1B/CHGA/TNF/PTPN22/ANXA1/RSAD2/PTGER4/TLR6 8 GO:0051494 negative regulation of cytoskeleton organization 8/1036 148/18670 0.5816 0.8358 0.738 ADD3/TRIM37/WAS/CKAP2/MAP2/NPM1/CLASP1/DYRK1A 8 GO:0034329 cell junction assembly 13/1036 241/18670 0.5824 0.8358 0.738 FLCN/PRKCH/ITGA6/TNF/LRP1/ARHGEF7/ACTN1/CLASP1/CD9/HEG1/ITGB4/SH3BP1/BCR 13 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 13/1036 241/18670 0.5824 0.8358 0.738 FKBP8/PARP1/TGFBR2/FLCN/HTRA1/ACVR1/TGFBR3/SULF1/UBA52/STK11/CITED2/UBB/ZBTB7A 13 GO:0031100 animal organ regeneration 4/1036 73/18670 0.5826 0.8358 0.738 PCNA/TGFBR2/TGFBR3/CSNK2A2 4 GO:0046128 purine ribonucleoside metabolic process 4/1036 73/18670 0.5826 0.8358 0.738 ENPP4/MFN1/AHCY/APRT 4 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 4/1036 73/18670 0.5826 0.8358 0.738 CXCL11/HMGN2/ELANE/PGLYRP4 4 GO:0006636 unsaturated fatty acid biosynthetic process 3/1036 54/18670 0.5827 0.8358 0.738 IL1B/ANXA1/AKR1C3 3 GO:0010524 positive regulation of calcium ion transport into cytosol 3/1036 54/18670 0.5827 0.8358 0.738 CXCL11/P2RX5/NTSR1 3 GO:0030042 actin filament depolymerization 3/1036 54/18670 0.5827 0.8358 0.738 ADD3/MICAL1/SH3BP1 3 GO:0030199 collagen fibril organization 3/1036 54/18670 0.5827 0.8358 0.738 ADAMTS2/PLOD1/COLGALT1 3 GO:0046164 alcohol catabolic process 3/1036 54/18670 0.5827 0.8358 0.738 NTSR1/AKR1C3/ALDH3B1 3 GO:0050994 regulation of lipid catabolic process 3/1036 54/18670 0.5827 0.8358 0.738 IL1B/CRTC3/TNF 3 GO:0051353 positive regulation of oxidoreductase activity 3/1036 54/18670 0.5827 0.8358 0.738 IFNG/IL1B/TNF 3 GO:0061005 cell differentiation involved in kidney development 3/1036 54/18670 0.5827 0.8358 0.738 PRKX/LIF/SIX2 3 GO:1900047 negative regulation of hemostasis 3/1036 54/18670 0.5827 0.8358 0.738 ABAT/F12/CD9 3 GO:0045787 positive regulation of cell cycle 21/1036 389/18670 0.5842 0.836 0.7382 PCNA/IL1A/IL1B/SFPQ/AURKC/CDC25B/ANAPC5/BTG2/ANKRD17/ANXA1/PHB2/SMARCD3/NPM1/RARA/NDC80/DYRK3/CITED2/FBXO5/PSMD10/ATRX/CDC7 21 GO:0035305 negative regulation of dephosphorylation 6/1036 111/18670 0.5853 0.836 0.7382 PPP1R17/PPP1R16B/PPP1R8/TNF/PKMYT1/MPHOSPH10 6 GO:1903509 liposaccharide metabolic process 6/1036 111/18670 0.5853 0.836 0.7382 ST3GAL5/CREM/ESYT1/ARSA/PGAP1/CERK 6 GO:0071902 positive regulation of protein serine/threonine kinase activity 18/1036 334/18670 0.5857 0.836 0.7382 IFNG/IL1B/MAGED1/TNF/CXCR4/RASGRP1/MAP4K5/MAPK3/UBA52/ELANE/MAP4K2/TLR6/PSMD10/DAXX/UBB/SOD1/FGF18/STRADA 18 GO:0003203 endocardial cushion morphogenesis 2/1036 35/18670 0.5858 0.836 0.7382 TGFBR2/ACVR1 2 GO:0010259 multicellular organism aging 2/1036 35/18670 0.5858 0.836 0.7382 MSH2/GHRHR 2 GO:0015695 organic cation transport 2/1036 35/18670 0.5858 0.836 0.7382 SLC22A13/SLC38A2 2 GO:0019433 triglyceride catabolic process 2/1036 35/18670 0.5858 0.836 0.7382 DDHD2/LIPE 2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 2/1036 35/18670 0.5858 0.836 0.7382 WAC/RPL11 2 GO:0034142 toll-like receptor 4 signaling pathway 2/1036 35/18670 0.5858 0.836 0.7382 PTPN22/LBP 2 GO:0045070 positive regulation of viral genome replication 2/1036 35/18670 0.5858 0.836 0.7382 CCL5/PABPC1 2 GO:0048333 mesodermal cell differentiation 2/1036 35/18670 0.5858 0.836 0.7382 ITGB4/SIX2 2 GO:0051294 establishment of spindle orientation 2/1036 35/18670 0.5858 0.836 0.7382 NDC80/CLASP1 2 GO:0070873 regulation of glycogen metabolic process 2/1036 35/18670 0.5858 0.836 0.7382 DYRK2/PASK 2 GO:0110111 negative regulation of animal organ morphogenesis 2/1036 35/18670 0.5858 0.836 0.7382 TNF/SULF1 2 GO:1902991 regulation of amyloid precursor protein catabolic process 2/1036 35/18670 0.5858 0.836 0.7382 IFNG/TNF 2 GO:1905332 positive regulation of morphogenesis of an epithelium 2/1036 35/18670 0.5858 0.836 0.7382 MAGED1/LIF 2 GO:1990774 tumor necrosis factor secretion 2/1036 35/18670 0.5858 0.836 0.7382 IFNG/SPHK2 2 GO:2000785 regulation of autophagosome assembly 2/1036 35/18670 0.5858 0.836 0.7382 SCFD1/FEZ1 2 GO:0006638 neutral lipid metabolic process 7/1036 130/18670 0.5872 0.8373 0.7394 DDHD2/ATG14/CETP/CAT/INSIG1/LIPE/DGKZ 7 GO:0016197 endosomal transport 12/1036 224/18670 0.592 0.8373 0.7394 LEPROTL1/WAS/STX10/EHD2/RAB9A/UBA52/ARL4C/VPS51/VPS37B/EHD3/UBB/GOSR1 12 GO:0007389 pattern specification process 24/1036 446/18670 0.5923 0.8373 0.7394 AIDA/FKBP8/TRA2B/TGFBR2/PRKACB/POGLUT1/DAAM2/BTG2/ACVR1/HSPB11/LHX3/BMPR1B/HOXA6/SMARCD3/MLLT3/BICC1/CITED2/ZBTB16/AMHR2/BPTF/PGAP1/XRCC2/SIX2/TMED2 24 GO:0048704 embryonic skeletal system morphogenesis 5/1036 93/18670 0.5933 0.8373 0.7394 TGFBR2/GNAS/EIF4A3/HOXA6/SIX2 5 GO:0072080 nephron tubule development 5/1036 93/18670 0.5933 0.8373 0.7394 MYC/MAGED1/LIF/SIX2/ACAT1 5 GO:0009583 detection of light stimulus 4/1036 74/18670 0.5934 0.8373 0.7394 METAP1/FNTA/BEST1/METAP2 4 GO:0051145 smooth muscle cell differentiation 4/1036 74/18670 0.5934 0.8373 0.7394 TMEM204/ACVR1/ANKRD17/SMARCD3 4 GO:0060998 regulation of dendritic spine development 4/1036 74/18670 0.5934 0.8373 0.7394 CAPRIN2/DNM1L/DBN1/CAPRIN1 4 GO:0070373 negative regulation of ERK1 and ERK2 cascade 4/1036 74/18670 0.5934 0.8373 0.7394 RANBP9/FLCN/ATF3/LIF 4 GO:1900076 regulation of cellular response to insulin stimulus 4/1036 74/18670 0.5934 0.8373 0.7394 IL1B/NCK1/PRKCQ/PIK3R1 4 GO:0032411 positive regulation of transporter activity 6/1036 112/18670 0.5941 0.8373 0.7394 ABCB1/IFNG/NTSR1/ATP1B1/PON1/EHD3 6 GO:1903828 negative regulation of cellular protein localization 6/1036 112/18670 0.5941 0.8373 0.7394 FLCN/INSIG1/LEPROTL1/LILRB4/TERF1/UBE2J1 6 GO:0048568 embryonic organ development 23/1036 428/18670 0.5942 0.8373 0.7394 TRA2B/TGFBR2/GNAS/INSIG1/EIF4A3/ACVR1/TNF/LRIG1/HOXA6/PRKRA/SPINT1/RARA/MAPK3/LIF/CITED2/BPTF/SOD1/NTN1/SIX2/FZD2/IL3/BCR/TMED2 23 GO:0001541 ovarian follicle development 3/1036 55/18670 0.5953 0.8373 0.7394 PTX3/BMPR1B/SOD1 3 GO:0003229 ventricular cardiac muscle tissue development 3/1036 55/18670 0.5953 0.8373 0.7394 TNNI1/TGFBR3/HEG1 3 GO:0042304 regulation of fatty acid biosynthetic process 3/1036 55/18670 0.5953 0.8373 0.7394 IL1B/INSIG1/ANXA1 3 GO:0043113 receptor clustering 3/1036 55/18670 0.5953 0.8373 0.7394 MADCAM1/ITGA4/FNTA 3 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 3/1036 55/18670 0.5953 0.8373 0.7394 ATG14/CCKBR/PIK3R1 3 GO:0045620 negative regulation of lymphocyte differentiation 3/1036 55/18670 0.5953 0.8373 0.7394 ANXA1/TBX21/PGLYRP4 3 GO:0048016 inositol phosphate-mediated signaling 3/1036 55/18670 0.5953 0.8373 0.7394 DYRK2/ERBB3/TNF 3 GO:0098900 regulation of action potential 3/1036 55/18670 0.5953 0.8373 0.7394 ATP2A2/NTSR1/RANGRF 3 GO:0010466 negative regulation of peptidase activity 14/1036 262/18670 0.5969 0.8373 0.7394 WFDC1/LAMP3/MICAL1/BIRC3/SIAH2/RECK/SPINT1/PEBP1/CST7/TIMP2/TIMP4/CSN2/IGBP1/RPS6KA3 14 GO:0008360 regulation of cell shape 8/1036 150/18670 0.597 0.8373 0.7394 RHOH/RASA1/ITGA7/FYN/PLXNB2/ANXA1/PARVA/CCL11 8 GO:0016331 morphogenesis of embryonic epithelium 8/1036 150/18670 0.597 0.8373 0.7394 PRKACB/RPS7/PLXNB2/SPINT1/SULF1/RARA/FZD2/TMED2 8 GO:0022604 regulation of cell morphogenesis 26/1036 484/18670 0.5974 0.8373 0.7394 RHOH/C1QBP/RASA1/ARHGAP4/ITGA7/CPNE6/FYN/CAPRIN2/CXCR4/PLXNB2/ANXA1/MAP2/LRP1/SEMA4G/DNM1L/ARHGEF7/PARVA/SEMA3G/STK11/CCL11/DBN1/CAPRIN1/DSCAM/NTN1/ADNP/EFNB3 26 GO:0045665 negative regulation of neuron differentiation 12/1036 225/18670 0.5982 0.8373 0.7394 CD38/ARHGAP4/MAP2/LRP1/SEMA4G/TLX3/SEMA3G/HMG20A/NTN1/PAQR3/EFNB3/CRMP1 12 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1/1036 16/18670 0.599 0.8373 0.7394 DDX1 1 GO:0001732 formation of cytoplasmic translation initiation complex 1/1036 16/18670 0.599 0.8373 0.7394 EIF5 1 GO:0002070 epithelial cell maturation 1/1036 16/18670 0.599 0.8373 0.7394 XBP1 1 GO:0002475 antigen processing and presentation via MHC class Ib 1/1036 16/18670 0.599 0.8373 0.7394 CD1A 1 GO:0003222 ventricular trabecula myocardium morphogenesis 1/1036 16/18670 0.599 0.8373 0.7394 HEG1 1 GO:0006103 2-oxoglutarate metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 DLD 1 GO:0006206 pyrimidine nucleobase metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 CMPK1 1 GO:0006837 serotonin transport 1/1036 16/18670 0.599 0.8373 0.7394 P2RX1 1 GO:0006957 complement activation, alternative pathway 1/1036 16/18670 0.599 0.8373 0.7394 C8B 1 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 UCKL1 1 GO:0010225 response to UV-C 1/1036 16/18670 0.599 0.8373 0.7394 HMGN1 1 GO:0010566 regulation of ketone biosynthetic process 1/1036 16/18670 0.599 0.8373 0.7394 AKR1C3 1 GO:0010820 positive regulation of T cell chemotaxis 1/1036 16/18670 0.599 0.8373 0.7394 CCL5 1 GO:0016114 terpenoid biosynthetic process 1/1036 16/18670 0.599 0.8373 0.7394 AKR1C3 1 GO:0030033 microvillus assembly 1/1036 16/18670 0.599 0.8373 0.7394 RAPGEF6 1 GO:0030252 growth hormone secretion 1/1036 16/18670 0.599 0.8373 0.7394 GHRHR 1 GO:0030397 membrane disassembly 1/1036 16/18670 0.599 0.8373 0.7394 VRK1 1 GO:0031958 corticosteroid receptor signaling pathway 1/1036 16/18670 0.599 0.8373 0.7394 CRY1 1 GO:0033033 negative regulation of myeloid cell apoptotic process 1/1036 16/18670 0.599 0.8373 0.7394 CCL5 1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 1/1036 16/18670 0.599 0.8373 0.7394 WAS 1 GO:0035461 vitamin transmembrane transport 1/1036 16/18670 0.599 0.8373 0.7394 SLC25A32 1 GO:0036124 histone H3-K9 trimethylation 1/1036 16/18670 0.599 0.8373 0.7394 ATRX 1 GO:0042222 interleukin-1 biosynthetic process 1/1036 16/18670 0.599 0.8373 0.7394 IFNG 1 GO:0042448 progesterone metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 AKR1C3 1 GO:0043031 negative regulation of macrophage activation 1/1036 16/18670 0.599 0.8373 0.7394 CST7 1 GO:0045986 negative regulation of smooth muscle contraction 1/1036 16/18670 0.599 0.8373 0.7394 SOD1 1 GO:0046325 negative regulation of glucose import 1/1036 16/18670 0.599 0.8373 0.7394 TNF 1 GO:0046519 sphingoid metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 SPHK2 1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 1/1036 16/18670 0.599 0.8373 0.7394 ATP2A2 1 GO:0050655 dermatan sulfate proteoglycan metabolic process 1/1036 16/18670 0.599 0.8373 0.7394 CHST12 1 GO:0051081 nuclear envelope disassembly 1/1036 16/18670 0.599 0.8373 0.7394 VRK1 1 GO:0051382 kinetochore assembly 1/1036 16/18670 0.599 0.8373 0.7394 RNF4 1 GO:0051503 adenine nucleotide transport 1/1036 16/18670 0.599 0.8373 0.7394 SLC25A5 1 GO:0051923 sulfation 1/1036 16/18670 0.599 0.8373 0.7394 TPST1 1 GO:0060413 atrial septum morphogenesis 1/1036 16/18670 0.599 0.8373 0.7394 ACVR1 1 GO:0060572 morphogenesis of an epithelial bud 1/1036 16/18670 0.599 0.8373 0.7394 SULF1 1 GO:0070593 dendrite self-avoidance 1/1036 16/18670 0.599 0.8373 0.7394 DSCAM 1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum 1/1036 16/18670 0.599 0.8373 0.7394 EDEM1 1 GO:0071380 cellular response to prostaglandin E stimulus 1/1036 16/18670 0.599 0.8373 0.7394 PTGER4 1 GO:0071545 inositol phosphate catabolic process 1/1036 16/18670 0.599 0.8373 0.7394 NTSR1 1 GO:0071732 cellular response to nitric oxide 1/1036 16/18670 0.599 0.8373 0.7394 MTR 1 GO:0072488 ammonium transmembrane transport 1/1036 16/18670 0.599 0.8373 0.7394 RHAG 1 GO:0080182 histone H3-K4 trimethylation 1/1036 16/18670 0.599 0.8373 0.7394 CTR9 1 GO:0086103 G protein-coupled receptor signaling pathway involved in heart process 1/1036 16/18670 0.599 0.8373 0.7394 CHGA 1 GO:0097067 cellular response to thyroid hormone stimulus 1/1036 16/18670 0.599 0.8373 0.7394 GCLC 1 GO:0099170 postsynaptic modulation of chemical synaptic transmission 1/1036 16/18670 0.599 0.8373 0.7394 EIF4A3 1 GO:1900242 regulation of synaptic vesicle endocytosis 1/1036 16/18670 0.599 0.8373 0.7394 DNM1L 1 GO:1900451 positive regulation of glutamate receptor signaling pathway 1/1036 16/18670 0.599 0.8373 0.7394 IFNG 1 GO:1903541 regulation of exosomal secretion 1/1036 16/18670 0.599 0.8373 0.7394 IFNG 1 GO:1904294 positive regulation of ERAD pathway 1/1036 16/18670 0.599 0.8373 0.7394 EDEM1 1 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 1/1036 16/18670 0.599 0.8373 0.7394 ATP1B1 1 GO:2000846 regulation of corticosteroid hormone secretion 1/1036 16/18670 0.599 0.8373 0.7394 CRY1 1 GO:0003417 growth plate cartilage development 2/1036 36/18670 0.6013 0.8382 0.7401 TGFBR2/RARA 2 GO:0006007 glucose catabolic process 2/1036 36/18670 0.6013 0.8382 0.7401 PGK1/PFKP 2 GO:0006699 bile acid biosynthetic process 2/1036 36/18670 0.6013 0.8382 0.7401 SCP2/CH25H 2 GO:0034390 smooth muscle cell apoptotic process 2/1036 36/18670 0.6013 0.8382 0.7401 IFNG/IL12B 2 GO:0034391 regulation of smooth muscle cell apoptotic process 2/1036 36/18670 0.6013 0.8382 0.7401 IFNG/IL12B 2 GO:0035137 hindlimb morphogenesis 2/1036 36/18670 0.6013 0.8382 0.7401 GNAS/ZBTB16 2 GO:0071709 membrane assembly 2/1036 36/18670 0.6013 0.8382 0.7401 EMP2/RFTN1 2 GO:0090218 positive regulation of lipid kinase activity 2/1036 36/18670 0.6013 0.8382 0.7401 ATG14/DGKZ 2 GO:0090313 regulation of protein targeting to membrane 2/1036 36/18670 0.6013 0.8382 0.7401 FYN/MFF 2 GO:0090322 regulation of superoxide metabolic process 2/1036 36/18670 0.6013 0.8382 0.7401 TNF/SOD1 2 GO:2000310 regulation of NMDA receptor activity 2/1036 36/18670 0.6013 0.8382 0.7401 IFNG/CAPN1 2 GO:0002064 epithelial cell development 11/1036 207/18670 0.6025 0.839 0.7409 IL1B/PPP1R16B/TNF/CXCR4/HRH2/BCL11B/XBP1/RARA/HEG1/SOD1/ATRX 11 GO:0034284 response to monosaccharide 11/1036 207/18670 0.6025 0.839 0.7409 TRA2B/TGFBR2/OXCT1/CAT/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/TRH/GHRHR 11 GO:0048640 negative regulation of developmental growth 6/1036 113/18670 0.6029 0.839 0.7409 TGFBR2/ARHGAP4/MAP2/SEMA4G/SEMA3G/NTN1 6 GO:0000726 non-recombinational repair 5/1036 94/18670 0.6029 0.839 0.7409 PSMD14/PIAS4/HERC2/ZBTB7A/POLQ 5 GO:0006906 vesicle fusion 5/1036 94/18670 0.6029 0.839 0.7409 ANXA1/STX10/STX8/TBC1D4/GOSR1 5 GO:0060993 kidney morphogenesis 5/1036 94/18670 0.6029 0.839 0.7409 MYC/MAGED1/PRKX/LIF/SIX2 5 GO:0042476 odontogenesis 7/1036 132/18670 0.6035 0.8394 0.7412 ZNF22/ITGA6/HTRA1/SCN10A/BCL11B/AMBN/ITGB4 7 GO:0072175 epithelial tube formation 7/1036 132/18670 0.6035 0.8394 0.7412 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0032482 Rab protein signal transduction 4/1036 75/18670 0.6041 0.8394 0.7412 IFT22/RAB9A/RABL3/RAB36 4 GO:0043242 negative regulation of protein complex disassembly 4/1036 75/18670 0.6041 0.8394 0.7412 ADD3/TNF/CKAP2/CLASP1 4 GO:0051303 establishment of chromosome localization 4/1036 75/18670 0.6041 0.8394 0.7412 CDC23/NDC80/RRS1/TERF1 4 GO:1902117 positive regulation of organelle assembly 4/1036 75/18670 0.6041 0.8394 0.7412 ATMIN/DYNLL1/TNF/ZMYND10 4 GO:0006022 aminoglycan metabolic process 9/1036 170/18670 0.6058 0.8406 0.7423 NFKB1/SLC35D1/IL1B/CHST12/CHPF2/SGSH/IL15/B3GNT2/PGLYRP4 9 GO:0000768 syncytium formation by plasma membrane fusion 3/1036 56/18670 0.6076 0.8406 0.7423 EHD2/KCNH1/CD9 3 GO:0045292 mRNA cis splicing, via spliceosome 3/1036 56/18670 0.6076 0.8406 0.7423 SRSF8/SRSF10/WBP11 3 GO:0060113 inner ear receptor cell differentiation 3/1036 56/18670 0.6076 0.8406 0.7423 GABRB2/SOD1/FZD2 3 GO:0070936 protein K48-linked ubiquitination 3/1036 56/18670 0.6076 0.8406 0.7423 TRIM44/RNF115/RNF4 3 GO:0090307 mitotic spindle assembly 3/1036 56/18670 0.6076 0.8406 0.7423 KIF2A/AURKC/CLASP1 3 GO:0140253 cell-cell fusion 3/1036 56/18670 0.6076 0.8406 0.7423 EHD2/KCNH1/CD9 3 GO:1905515 non-motile cilium assembly 3/1036 56/18670 0.6076 0.8406 0.7423 ATMIN/DYNLL1/PCM1 3 GO:0050792 regulation of viral process 11/1036 208/18670 0.6089 0.8406 0.7423 CCL5/PTX3/LAMP3/ZFP36/TNF/CXCR4/RSAD2/PABPC1/APOBEC3G/VPS37B/FCN1 11 GO:0007224 smoothened signaling pathway 7/1036 133/18670 0.6115 0.8406 0.7423 FKBP8/DYRK2/TGFBR2/RORA/PRKACB/HSPB11/CD3E 7 GO:0045446 endothelial cell differentiation 6/1036 114/18670 0.6115 0.8406 0.7423 IL1B/PPP1R16B/ACVR1/TNF/CXCR4/HEG1 6 GO:0060349 bone morphogenesis 6/1036 114/18670 0.6115 0.8406 0.7423 TGFBR2/GNAS/INSIG1/BMPR1B/RARA/FGF18 6 GO:0045069 regulation of viral genome replication 5/1036 95/18670 0.6123 0.8406 0.7423 CCL5/TNF/RSAD2/PABPC1/APOBEC3G 5 GO:0051651 maintenance of location in cell 5/1036 95/18670 0.6123 0.8406 0.7423 SKP1/INSIG1/SUPT7L/SYNE1/DBN1 5 GO:0061326 renal tubule development 5/1036 95/18670 0.6123 0.8406 0.7423 MYC/MAGED1/LIF/SIX2/ACAT1 5 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 5/1036 95/18670 0.6123 0.8406 0.7423 RCHY1/GCLC/RBX1/TRIB2/PSMD10 5 GO:0071375 cellular response to peptide hormone stimulus 17/1036 321/18670 0.6143 0.8406 0.7423 PARP1/NFKB1/SOS1/IL1B/NCK1/PRKCQ/PRKACB/GCLC/FYN/XBP1/TBC1D4/PRKAR2B/PIK3CA/PIK3C2A/GHRHR/APRT/PIK3R1 17 GO:0007492 endoderm development 4/1036 76/18670 0.6146 0.8406 0.7423 CTR9/ITGA4/ITGA7/BPTF 4 GO:0042278 purine nucleoside metabolic process 4/1036 76/18670 0.6146 0.8406 0.7423 ENPP4/MFN1/AHCY/APRT 4 GO:0050000 chromosome localization 4/1036 76/18670 0.6146 0.8406 0.7423 CDC23/NDC80/RRS1/TERF1 4 GO:0072088 nephron epithelium morphogenesis 4/1036 76/18670 0.6146 0.8406 0.7423 MYC/MAGED1/LIF/SIX2 4 GO:0017148 negative regulation of translation 11/1036 209/18670 0.6153 0.8406 0.7423 EIF4A3/BTG2/ZFP36/CAPRIN2/TIA1/HNRNPR/PUM1/RARA/CAPRIN1/KHSRP/FXR1 11 GO:0071229 cellular response to acid chemical 11/1036 209/18670 0.6153 0.8406 0.7423 SESN1/GCLC/FYN/TNF/PHB2/XBP1/RARA/GLRA1/PTGER4/AKR1C3/SETX 11 GO:0003156 regulation of animal organ formation 2/1036 37/18670 0.6164 0.8406 0.7423 SULF1/CITED2 2 GO:0007339 binding of sperm to zona pellucida 2/1036 37/18670 0.6164 0.8406 0.7423 CCT7/CCT2 2 GO:0007431 salivary gland development 2/1036 37/18670 0.6164 0.8406 0.7423 TNF/XBP1 2 GO:0014037 Schwann cell differentiation 2/1036 37/18670 0.6164 0.8406 0.7423 ERBB3/SOD1 2 GO:0021587 cerebellum morphogenesis 2/1036 37/18670 0.6164 0.8406 0.7423 RORA/HERC1 2 GO:0030201 heparan sulfate proteoglycan metabolic process 2/1036 37/18670 0.6164 0.8406 0.7423 SGSH/SULF1 2 GO:0033280 response to vitamin D 2/1036 37/18670 0.6164 0.8406 0.7423 IL15/TRIM24 2 GO:0042307 positive regulation of protein import into nucleus 2/1036 37/18670 0.6164 0.8406 0.7423 IFNG/PIK3R1 2 GO:0045777 positive regulation of blood pressure 2/1036 37/18670 0.6164 0.8406 0.7423 HSD11B2/NMU 2 GO:0045923 positive regulation of fatty acid metabolic process 2/1036 37/18670 0.6164 0.8406 0.7423 IL1B/ANXA1 2 GO:0060323 head morphogenesis 2/1036 37/18670 0.6164 0.8406 0.7423 ARID5B/RRAS 2 GO:0086010 membrane depolarization during action potential 2/1036 37/18670 0.6164 0.8406 0.7423 SCN10A/RANGRF 2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2/1036 37/18670 0.6164 0.8406 0.7423 ANXA1/PIK3C2A 2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 2/1036 37/18670 0.6164 0.8406 0.7423 C1QBP/ARHGEF7 2 GO:1903427 negative regulation of reactive oxygen species biosynthetic process 2/1036 37/18670 0.6164 0.8406 0.7423 FYN/KHSRP 2 GO:0032355 response to estradiol 7/1036 134/18670 0.6194 0.8406 0.7423 CD38/PCNA/WFDC1/CAT/ANXA1/NCOA3/RARA 7 GO:0001755 neural crest cell migration 3/1036 57/18670 0.6197 0.8406 0.7423 ACVR1/SEMA4G/SEMA3G 3 GO:0050819 negative regulation of coagulation 3/1036 57/18670 0.6197 0.8406 0.7423 ABAT/F12/CD9 3 GO:0051310 metaphase plate congression 3/1036 57/18670 0.6197 0.8406 0.7423 CDC23/NDC80/RRS1 3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 3/1036 57/18670 0.6197 0.8406 0.7423 OXCT1/DYNLL1/LRP1 3 GO:0021543 pallium development 9/1036 172/18670 0.6199 0.8406 0.7423 TRA2B/BTG2/CSNK2A2/LRP1/RARA/ATAT1/SLC38A2/TMEM14B/FEZ1 9 GO:0006023 aminoglycan biosynthetic process 6/1036 115/18670 0.62 0.8406 0.7423 NFKB1/SLC35D1/IL1B/CHST12/CHPF2/B3GNT2 6 GO:0001675 acrosome assembly 1/1036 17/18670 0.6213 0.8406 0.7423 PLA2G3 1 GO:0006089 lactate metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 LDHB 1 GO:0006544 glycine metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 SLC25A32 1 GO:0006577 amino-acid betaine metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 ACADM 1 GO:0006595 polyamine metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 ODC1 1 GO:0006825 copper ion transport 1/1036 17/18670 0.6213 0.8406 0.7423 CUTC 1 GO:0006883 cellular sodium ion homeostasis 1/1036 17/18670 0.6213 0.8406 0.7423 ATP1B1 1 GO:0007076 mitotic chromosome condensation 1/1036 17/18670 0.6213 0.8406 0.7423 SMC2 1 GO:0007379 segment specification 1/1036 17/18670 0.6213 0.8406 0.7423 MLLT3 1 GO:0010819 regulation of T cell chemotaxis 1/1036 17/18670 0.6213 0.8406 0.7423 CCL5 1 GO:0015868 purine ribonucleotide transport 1/1036 17/18670 0.6213 0.8406 0.7423 SLC25A5 1 GO:0016584 nucleosome positioning 1/1036 17/18670 0.6213 0.8406 0.7423 SMARCA5 1 GO:0021514 ventral spinal cord interneuron differentiation 1/1036 17/18670 0.6213 0.8406 0.7423 LHX3 1 GO:0031643 positive regulation of myelination 1/1036 17/18670 0.6213 0.8406 0.7423 CST7 1 GO:0032780 negative regulation of ATPase activity 1/1036 17/18670 0.6213 0.8406 0.7423 OXA1L 1 GO:0032966 negative regulation of collagen biosynthetic process 1/1036 17/18670 0.6213 0.8406 0.7423 IL6 1 GO:0033599 regulation of mammary gland epithelial cell proliferation 1/1036 17/18670 0.6213 0.8406 0.7423 PHB2 1 GO:0034433 steroid esterification 1/1036 17/18670 0.6213 0.8406 0.7423 ACAT1 1 GO:0034434 sterol esterification 1/1036 17/18670 0.6213 0.8406 0.7423 ACAT1 1 GO:0034435 cholesterol esterification 1/1036 17/18670 0.6213 0.8406 0.7423 ACAT1 1 GO:0034501 protein localization to kinetochore 1/1036 17/18670 0.6213 0.8406 0.7423 NDC80 1 GO:0035313 wound healing, spreading of epidermal cells 1/1036 17/18670 0.6213 0.8406 0.7423 CLASP1 1 GO:0035729 cellular response to hepatocyte growth factor stimulus 1/1036 17/18670 0.6213 0.8406 0.7423 GCLC 1 GO:0035930 corticosteroid hormone secretion 1/1036 17/18670 0.6213 0.8406 0.7423 CRY1 1 GO:0036158 outer dynein arm assembly 1/1036 17/18670 0.6213 0.8406 0.7423 ZMYND10 1 GO:0038092 nodal signaling pathway 1/1036 17/18670 0.6213 0.8406 0.7423 CITED2 1 GO:0042249 establishment of planar polarity of embryonic epithelium 1/1036 17/18670 0.6213 0.8406 0.7423 FZD2 1 GO:0042790 nucleolar large rRNA transcription by RNA polymerase I 1/1036 17/18670 0.6213 0.8406 0.7423 NOL11 1 GO:0042953 lipoprotein transport 1/1036 17/18670 0.6213 0.8406 0.7423 LRP1 1 GO:0042994 cytoplasmic sequestering of transcription factor 1/1036 17/18670 0.6213 0.8406 0.7423 PSMD10 1 GO:0043649 dicarboxylic acid catabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 GAD2 1 GO:0043968 histone H2A acetylation 1/1036 17/18670 0.6213 0.8406 0.7423 SPHK2 1 GO:0044872 lipoprotein localization 1/1036 17/18670 0.6213 0.8406 0.7423 LRP1 1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/1036 17/18670 0.6213 0.8406 0.7423 APOBEC3G 1 GO:0045324 late endosome to vacuole transport 1/1036 17/18670 0.6213 0.8406 0.7423 LEPROTL1 1 GO:0045725 positive regulation of glycogen biosynthetic process 1/1036 17/18670 0.6213 0.8406 0.7423 DYRK2 1 GO:0046068 cGMP metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 RORA 1 GO:0046500 S-adenosylmethionine metabolic process 1/1036 17/18670 0.6213 0.8406 0.7423 AHCY 1 GO:0048311 mitochondrion distribution 1/1036 17/18670 0.6213 0.8406 0.7423 DNM1L 1 GO:0048535 lymph node development 1/1036 17/18670 0.6213 0.8406 0.7423 IL15 1 GO:0050884 neuromuscular process controlling posture 1/1036 17/18670 0.6213 0.8406 0.7423 GLRA1 1 GO:0051969 regulation of transmission of nerve impulse 1/1036 17/18670 0.6213 0.8406 0.7423 GLRA1 1 GO:0055070 copper ion homeostasis 1/1036 17/18670 0.6213 0.8406 0.7423 CUTC 1 GO:0060046 regulation of acrosome reaction 1/1036 17/18670 0.6213 0.8406 0.7423 GLRA1 1 GO:0060644 mammary gland epithelial cell differentiation 1/1036 17/18670 0.6213 0.8406 0.7423 LBH 1 GO:0060850 regulation of transcription involved in cell fate commitment 1/1036 17/18670 0.6213 0.8406 0.7423 RORA 1 GO:0062033 positive regulation of mitotic sister chromatid segregation 1/1036 17/18670 0.6213 0.8406 0.7423 ANAPC5 1 GO:0072673 lamellipodium morphogenesis 1/1036 17/18670 0.6213 0.8406 0.7423 ARHGEF7 1 GO:0090185 negative regulation of kidney development 1/1036 17/18670 0.6213 0.8406 0.7423 FLCN 1 GO:0097329 response to antimetabolite 1/1036 17/18670 0.6213 0.8406 0.7423 ATRX 1 GO:0098884 postsynaptic neurotransmitter receptor internalization 1/1036 17/18670 0.6213 0.8406 0.7423 AP2B1 1 GO:0140239 postsynaptic endocytosis 1/1036 17/18670 0.6213 0.8406 0.7423 AP2B1 1 GO:1901524 regulation of mitophagy 1/1036 17/18670 0.6213 0.8406 0.7423 OPTN 1 GO:1902683 regulation of receptor localization to synapse 1/1036 17/18670 0.6213 0.8406 0.7423 DBN1 1 GO:1904380 endoplasmic reticulum mannose trimming 1/1036 17/18670 0.6213 0.8406 0.7423 EDEM1 1 GO:2000001 regulation of DNA damage checkpoint 1/1036 17/18670 0.6213 0.8406 0.7423 CRY1 1 GO:2000641 regulation of early endosome to late endosome transport 1/1036 17/18670 0.6213 0.8406 0.7423 MAPK3 1 GO:2000811 negative regulation of anoikis 1/1036 17/18670 0.6213 0.8406 0.7423 PIK3CA 1 GO:0034976 response to endoplasmic reticulum stress 15/1036 285/18670 0.6213 0.8406 0.7423 UFC1/NCK1/USP25/TMX1/ATP2A2/DERL1/ATF3/GORASP2/XBP1/EDEM1/PMAIP1/PIK3R1/RCN3/UBE2J1/GFPT1 15 GO:0097327 response to antineoplastic agent 5/1036 96/18670 0.6216 0.8408 0.7425 PCNA/SPHK2/DAXX/ATRX/ADAM15 5 GO:0001558 regulation of cell growth 22/1036 416/18670 0.6238 0.8435 0.7449 CD38/FLCN/WFDC1/PRKCQ/ARHGAP4/CPNE6/CAPRIN2/CXCR4/MAP2/LRP1/SEMA4G/SPHK2/SEMA3G/STK11/DBN1/RBBP7/PSMD10/DSCAM/NTN1/ADAM15/ADNP/RPS6KA3 22 GO:0016575 histone deacetylation 4/1036 77/18670 0.625 0.8445 0.7457 SFPQ/SPHK2/HDAC4/ZNHIT1 4 GO:0035050 embryonic heart tube development 4/1036 77/18670 0.625 0.8445 0.7457 TGFBR2/ACVR1/CITED2/TMED2 4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 4/1036 77/18670 0.625 0.8445 0.7457 DROSHA/RRS1/RPS21/RNASE1 4 GO:0055067 monovalent inorganic cation homeostasis 8/1036 154/18670 0.6268 0.8464 0.7474 SLC12A5/CCKBR/MAPK3/ATP1B1/CA7/SLAMF8/CYP4A11/CYP4F12 8 GO:1990845 adaptive thermogenesis 8/1036 154/18670 0.6268 0.8464 0.7474 FLCN/GNAS/PLCL1/CXCR4/STK11/FH/IL15/ZNF516 8 GO:0060359 response to ammonium ion 7/1036 135/18670 0.6272 0.8464 0.7474 ABAT/CASP7/CHRM5/CXCR4/MAPK3/CHRM2/GABRB2 7 GO:1903825 organic acid transmembrane transport 7/1036 135/18670 0.6272 0.8464 0.7474 SLC35D1/SLC25A32/SLC38A1/NTSR1/SLC7A5/SLC38A2/SLC1A3 7 GO:1905039 carboxylic acid transmembrane transport 7/1036 135/18670 0.6272 0.8464 0.7474 SLC35D1/SLC25A32/SLC38A1/NTSR1/SLC7A5/SLC38A2/SLC1A3 7 GO:0007569 cell aging 6/1036 116/18670 0.6284 0.8479 0.7487 RWDD1/EEF1E1/ATR/NPM1/FBXO5/SOD1 6 GO:0045926 negative regulation of growth 13/1036 249/18670 0.6298 0.8482 0.749 TGFBR2/FLCN/WFDC1/ARHGAP4/CAPRIN2/MAP2/SEMA4G/SPHK2/SEMA3G/STK11/RBBP7/NTN1/ADAM15 13 GO:0001657 ureteric bud development 5/1036 97/18670 0.6308 0.8482 0.749 MYC/CAT/MAGED1/RARA/SIX2 5 GO:0060996 dendritic spine development 5/1036 97/18670 0.6308 0.8482 0.749 SLC12A5/CAPRIN2/DNM1L/DBN1/CAPRIN1 5 GO:0001825 blastocyst formation 2/1036 38/18670 0.631 0.8482 0.749 CTR9/HOPX 2 GO:0002707 negative regulation of lymphocyte mediated immunity 2/1036 38/18670 0.631 0.8482 0.749 CD96/TBX21 2 GO:0006778 porphyrin-containing compound metabolic process 2/1036 38/18670 0.631 0.8482 0.749 SUCLA2/RSAD1 2 GO:0007223 Wnt signaling pathway, calcium modulating pathway 2/1036 38/18670 0.631 0.8482 0.749 PLCB3/FZD2 2 GO:0032094 response to food 2/1036 38/18670 0.631 0.8482 0.749 HSD11B2/TMEM135 2 GO:0046636 negative regulation of alpha-beta T cell activation 2/1036 38/18670 0.631 0.8482 0.749 ANXA1/TBX21 2 GO:0046825 regulation of protein export from nucleus 2/1036 38/18670 0.631 0.8482 0.749 IL1B/RIOK2 2 GO:0048009 insulin-like growth factor receptor signaling pathway 2/1036 38/18670 0.631 0.8482 0.749 GHRHR/PIK3R1 2 GO:0086005 ventricular cardiac muscle cell action potential 2/1036 38/18670 0.631 0.8482 0.749 GPD1L/KCNQ1 2 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 2/1036 38/18670 0.631 0.8482 0.749 ATP1B1/EHD3 2 GO:0006949 syncytium formation 3/1036 58/18670 0.6315 0.8482 0.749 EHD2/KCNH1/CD9 3 GO:0030520 intracellular estrogen receptor signaling pathway 3/1036 58/18670 0.6315 0.8482 0.749 LBH/PARP1/PHB2 3 GO:0046605 regulation of centrosome cycle 3/1036 58/18670 0.6315 0.8482 0.749 TRIM37/NPM1/CEP76 3 GO:0098930 axonal transport 3/1036 58/18670 0.6315 0.8482 0.749 MAP2/SOD1/FEZ1 3 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 3/1036 58/18670 0.6315 0.8482 0.749 ATF3/BMPR1B/PMAIP1 3 GO:0051224 negative regulation of protein transport 10/1036 193/18670 0.6338 0.8486 0.7493 IL1B/INSIG1/CHGA/TNF/PTPN22/ANXA1/RSAD2/PTGER4/TLR6/UBE2J1 10 GO:0007292 female gamete generation 7/1036 136/18670 0.635 0.8486 0.7493 SOS1/PTX3/AURKC/CDC25B/BMPR1B/FBXO5/UBB 7 GO:0008306 associative learning 4/1036 78/18670 0.6352 0.8486 0.7493 DDHD2/EIF4A3/BTG2/HRH2 4 GO:0042246 tissue regeneration 4/1036 78/18670 0.6352 0.8486 0.7493 TGFBR2/ANXA1/CD9/ADAM15 4 GO:0072028 nephron morphogenesis 4/1036 78/18670 0.6352 0.8486 0.7493 MYC/MAGED1/LIF/SIX2 4 GO:2000300 regulation of synaptic vesicle exocytosis 4/1036 78/18670 0.6352 0.8486 0.7493 ATP2A2/P2RX1/DNM1L/CHRM2 4 GO:0010721 negative regulation of cell development 18/1036 344/18670 0.636 0.8486 0.7493 CD38/IL6/IL1B/DAAM2/ARHGAP4/TNF/MAP2/LRP1/SEMA4G/PCM1/TLX3/SEMA3G/CCL11/HMG20A/NTN1/PAQR3/EFNB3/CRMP1 18 GO:0043666 regulation of phosphoprotein phosphatase activity 6/1036 117/18670 0.6367 0.8486 0.7493 PPP1R17/PPP1R16B/PPP2R5C/PPP1R8/TNF/IGBP1 6 GO:0048562 embryonic organ morphogenesis 15/1036 288/18670 0.6375 0.8486 0.7493 TGFBR2/GNAS/INSIG1/EIF4A3/ACVR1/LRIG1/HOXA6/PRKRA/MAPK3/SOD1/NTN1/SIX2/FZD2/BCR/TMED2 15 GO:0001824 blastocyst development 5/1036 98/18670 0.6399 0.8486 0.7493 CTR9/EMG1/HOPX/LPAR6/NCAPG2 5 GO:0006626 protein targeting to mitochondrion 5/1036 98/18670 0.6399 0.8486 0.7493 CSNK2A2/AGK/TOMM20/HAX1/MFF 5 GO:0072163 mesonephric epithelium development 5/1036 98/18670 0.6399 0.8486 0.7493 MYC/CAT/MAGED1/RARA/SIX2 5 GO:0072164 mesonephric tubule development 5/1036 98/18670 0.6399 0.8486 0.7493 MYC/CAT/MAGED1/RARA/SIX2 5 GO:0099175 regulation of postsynapse organization 5/1036 98/18670 0.6399 0.8486 0.7493 FYN/CAPRIN2/DNM1L/DBN1/CAPRIN1 5 GO:0010921 regulation of phosphatase activity 9/1036 175/18670 0.6405 0.8486 0.7493 PPP1R17/IFNG/PPP1R16B/PPP2R5C/PPP1R8/TNF/IGBP1/PKMYT1/MPHOSPH10 9 GO:0042445 hormone metabolic process 12/1036 232/18670 0.6407 0.8486 0.7493 NFKB1/IFNG/IL1B/HSD11B2/TNF/FDX1/CYP2C9/AKR1B1/AKR1C3/RDH16/GHRHR/CTSG 12 GO:0030856 regulation of epithelial cell differentiation 8/1036 156/18670 0.6412 0.8486 0.7493 IFNG/IL1B/PRKCH/ZFP36/TNF/PRKX/NCOA3/LIF 8 GO:0045165 cell fate commitment 14/1036 270/18670 0.6419 0.8486 0.7493 FKBP8/IL6/CTR9/RORA/IL12B/ACVR1/LHX3/TBX21/BCL11B/IL23A/RARA/TLX3/SLAMF8/SIX2 14 GO:0045927 positive regulation of growth 14/1036 270/18670 0.6419 0.8486 0.7493 CD38/TGFBR2/CPNE6/TGFBR3/CXCR4/LRP1/RFTN1/DBN1/PSMD10/GHRHR/DSCAM/NTN1/ADNP/RPS6KA3 14 GO:0002098 tRNA wobble uridine modification 1/1036 18/18670 0.6423 0.8486 0.7493 MTO1 1 GO:0006349 regulation of gene expression by genetic imprinting 1/1036 18/18670 0.6423 0.8486 0.7493 KCNQ1 1 GO:0006607 NLS-bearing protein import into nucleus 1/1036 18/18670 0.6423 0.8486 0.7493 CBLB 1 GO:0006704 glucocorticoid biosynthetic process 1/1036 18/18670 0.6423 0.8486 0.7493 HSD11B2 1 GO:0007221 positive regulation of transcription of Notch receptor target 1/1036 18/18670 0.6423 0.8486 0.7493 RBM15 1 GO:0007252 I-kappaB phosphorylation 1/1036 18/18670 0.6423 0.8486 0.7493 TLR3 1 GO:0008090 retrograde axonal transport 1/1036 18/18670 0.6423 0.8486 0.7493 SOD1 1 GO:0009312 oligosaccharide biosynthetic process 1/1036 18/18670 0.6423 0.8486 0.7493 MGAT2 1 GO:0010713 negative regulation of collagen metabolic process 1/1036 18/18670 0.6423 0.8486 0.7493 IL6 1 GO:0015865 purine nucleotide transport 1/1036 18/18670 0.6423 0.8486 0.7493 SLC25A5 1 GO:0021756 striatum development 1/1036 18/18670 0.6423 0.8486 0.7493 BCL11B 1 GO:0031468 nuclear envelope reassembly 1/1036 18/18670 0.6423 0.8486 0.7493 VRK1 1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 1/1036 18/18670 0.6423 0.8486 0.7493 CTR9 1 GO:0034375 high-density lipoprotein particle remodeling 1/1036 18/18670 0.6423 0.8486 0.7493 CETP 1 GO:0034587 piRNA metabolic process 1/1036 18/18670 0.6423 0.8486 0.7493 MYBL1 1 GO:0035089 establishment of apical/basal cell polarity 1/1036 18/18670 0.6423 0.8486 0.7493 SH3BP1 1 GO:0035994 response to muscle stretch 1/1036 18/18670 0.6423 0.8486 0.7493 NFKB1 1 GO:0036148 phosphatidylglycerol acyl-chain remodeling 1/1036 18/18670 0.6423 0.8486 0.7493 PLA2G3 1 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 1/1036 18/18670 0.6423 0.8486 0.7493 APOBEC3G 1 GO:0045056 transcytosis 1/1036 18/18670 0.6423 0.8486 0.7493 LRP1 1 GO:0048339 paraxial mesoderm development 1/1036 18/18670 0.6423 0.8486 0.7493 POGLUT1 1 GO:0048557 embryonic digestive tract morphogenesis 1/1036 18/18670 0.6423 0.8486 0.7493 SIX2 1 GO:0050908 detection of light stimulus involved in visual perception 1/1036 18/18670 0.6423 0.8486 0.7493 BEST1 1 GO:0050962 detection of light stimulus involved in sensory perception 1/1036 18/18670 0.6423 0.8486 0.7493 BEST1 1 GO:0051782 negative regulation of cell division 1/1036 18/18670 0.6423 0.8486 0.7493 MYC 1 GO:0051895 negative regulation of focal adhesion assembly 1/1036 18/18670 0.6423 0.8486 0.7493 LRP1 1 GO:0060117 auditory receptor cell development 1/1036 18/18670 0.6423 0.8486 0.7493 SOD1 1 GO:0060192 negative regulation of lipase activity 1/1036 18/18670 0.6423 0.8486 0.7493 ANXA1 1 GO:0060546 negative regulation of necroptotic process 1/1036 18/18670 0.6423 0.8486 0.7493 BIRC3 1 GO:0060749 mammary gland alveolus development 1/1036 18/18670 0.6423 0.8486 0.7493 PHB2 1 GO:0060977 coronary vasculature morphogenesis 1/1036 18/18670 0.6423 0.8486 0.7493 TGFBR3 1 GO:0061377 mammary gland lobule development 1/1036 18/18670 0.6423 0.8486 0.7493 PHB2 1 GO:0070230 positive regulation of lymphocyte apoptotic process 1/1036 18/18670 0.6423 0.8486 0.7493 CCL5 1 GO:0070633 transepithelial transport 1/1036 18/18670 0.6423 0.8486 0.7493 BEST1 1 GO:0070875 positive regulation of glycogen metabolic process 1/1036 18/18670 0.6423 0.8486 0.7493 DYRK2 1 GO:0071318 cellular response to ATP 1/1036 18/18670 0.6423 0.8486 0.7493 SOD1 1 GO:0071371 cellular response to gonadotropin stimulus 1/1036 18/18670 0.6423 0.8486 0.7493 GCLC 1 GO:0071605 monocyte chemotactic protein-1 production 1/1036 18/18670 0.6423 0.8486 0.7493 IL1B 1 GO:0071637 regulation of monocyte chemotactic protein-1 production 1/1036 18/18670 0.6423 0.8486 0.7493 IL1B 1 GO:0072574 hepatocyte proliferation 1/1036 18/18670 0.6423 0.8486 0.7493 XBP1 1 GO:0072575 epithelial cell proliferation involved in liver morphogenesis 1/1036 18/18670 0.6423 0.8486 0.7493 XBP1 1 GO:0090026 positive regulation of monocyte chemotaxis 1/1036 18/18670 0.6423 0.8486 0.7493 CCL5 1 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis 1/1036 18/18670 0.6423 0.8486 0.7493 MAGED1 1 GO:0097094 craniofacial suture morphogenesis 1/1036 18/18670 0.6423 0.8486 0.7493 INSIG1 1 GO:0150079 negative regulation of neuroinflammatory response 1/1036 18/18670 0.6423 0.8486 0.7493 CST7 1 GO:1905276 regulation of epithelial tube formation 1/1036 18/18670 0.6423 0.8486 0.7493 FZD2 1 GO:2000479 regulation of cAMP-dependent protein kinase activity 1/1036 18/18670 0.6423 0.8486 0.7493 PRKAR2B 1 GO:0001658 branching involved in ureteric bud morphogenesis 3/1036 59/18670 0.6431 0.8488 0.7495 MYC/MAGED1/SIX2 3 GO:0007602 phototransduction 3/1036 59/18670 0.6431 0.8488 0.7495 METAP1/FNTA/METAP2 3 GO:0046847 filopodium assembly 3/1036 59/18670 0.6431 0.8488 0.7495 PPP1R16B/ITGA6/TRPM2 3 GO:2000351 regulation of endothelial cell apoptotic process 3/1036 59/18670 0.6431 0.8488 0.7495 ITGA4/TNF/AKR1C3 3 GO:0045765 regulation of angiogenesis 20/1036 383/18670 0.6434 0.849 0.7497 IL1A/IL6/PGK1/CCR3/TGFBR2/IL1B/PPP1R16B/RRAS/HSPB6/RECK/CXCR4/ANXA1/EMP2/TLR3/XBP1/SULF1/PIK3C2A/CCL11/STAB1/FGF18 20 GO:0010661 positive regulation of muscle cell apoptotic process 2/1036 39/18670 0.6451 0.849 0.7497 IFNG/IL12B 2 GO:0030049 muscle filament sliding 2/1036 39/18670 0.6451 0.849 0.7497 MYL1/TNNI1 2 GO:0030501 positive regulation of bone mineralization 2/1036 39/18670 0.6451 0.849 0.7497 ACVR1/BMPR1B 2 GO:0031062 positive regulation of histone methylation 2/1036 39/18670 0.6451 0.849 0.7497 AUTS2/CTR9 2 GO:0033275 actin-myosin filament sliding 2/1036 39/18670 0.6451 0.849 0.7497 MYL1/TNNI1 2 GO:0033574 response to testosterone 2/1036 39/18670 0.6451 0.849 0.7497 RWDD1/CA9 2 GO:0038179 neurotrophin signaling pathway 2/1036 39/18670 0.6451 0.849 0.7497 SOS1/CYFIP2 2 GO:0048713 regulation of oligodendrocyte differentiation 2/1036 39/18670 0.6451 0.849 0.7497 DAAM2/CXCR4 2 GO:0060969 negative regulation of gene silencing 2/1036 39/18670 0.6451 0.849 0.7497 ELAVL1/NCOR1 2 GO:1904591 positive regulation of protein import 2/1036 39/18670 0.6451 0.849 0.7497 IFNG/PIK3R1 2 GO:2000826 regulation of heart morphogenesis 2/1036 39/18670 0.6451 0.849 0.7497 TGFBR2/ACVR1 2 GO:0016358 dendrite development 12/1036 233/18670 0.6465 0.8506 0.7511 FYN/SLC12A5/CAPRIN2/MAP2/DNM1L/TMEM106B/STK11/DBN1/CAPRIN1/DSCAM/NTN1/CD3E 12 GO:0044782 cilium organization 20/1036 384/18670 0.648 0.8521 0.7525 CEP57/ATMIN/IFT22/DYNLL1/VDAC3/HSPB11/KIFAP3/PARVA/PRKAR2B/HAUS2/PCM1/CEP76/ABCC4/CLASP1/ATAT1/ABLIM1/EHD3/ZMYND10/PLA2G3/ATG5 20 GO:0051271 negative regulation of cellular component movement 20/1036 384/18670 0.648 0.8521 0.7525 FLCN/GPR18/RRAS/ARHGAP4/RECK/TGFBR3/WAS/LRP1/SEMA4G/SULF1/ACTN1/SEMA3G/PTGER4/CLASP1/CD9/CITED2/CCL25/ADAM15/SLAMF8/BCR 20 GO:0001708 cell fate specification 5/1036 99/18670 0.6488 0.8527 0.7529 FKBP8/LHX3/TBX21/TLX3/SIX2 5 GO:0019395 fatty acid oxidation 5/1036 99/18670 0.6488 0.8527 0.7529 ABCD3/ACADM/ETFA/SCP2/ACAT1 5 GO:0016311 dephosphorylation 25/1036 478/18670 0.6501 0.8542 0.7543 PTPN4/PPP1R17/IFNG/DUSP2/DUSP12/PPP1R16B/PPP2R5C/CHRM5/NCK1/CDC25B/PPP1R8/CYCS/PPP1CC/TNF/PTPN22/PTPN7/LCK/PON1/STK11/DUSP21/IGBP1/PKMYT1/DUSP13/MPHOSPH10/DAPP1 25 GO:0010810 regulation of cell-substrate adhesion 11/1036 215/18670 0.6525 0.8548 0.7548 C1QBP/ITGA6/RASA1/LRP1/ARHGEF7/EMP2/CLASP1/CCL25/ADAM15/CD3E/PIK3R1 11 GO:0007368 determination of left/right symmetry 6/1036 119/18670 0.653 0.8548 0.7548 TGFBR2/DAAM2/ACVR1/BICC1/CITED2/TMED2 6 GO:0032515 negative regulation of phosphoprotein phosphatase activity 3/1036 60/18670 0.6544 0.8548 0.7548 PPP1R17/PPP1R8/TNF 3 GO:1902808 positive regulation of cell cycle G1/S phase transition 3/1036 60/18670 0.6544 0.8548 0.7548 ANKRD17/ANXA1/PHB2 3 GO:0007215 glutamate receptor signaling pathway 5/1036 100/18670 0.6575 0.8548 0.7548 IFNG/CAPN1/FYN/TRPM1/GRIN2D 5 GO:0036503 ERAD pathway 5/1036 100/18670 0.6575 0.8548 0.7548 USP25/DERL1/EDEM1/RCN3/UBE2J1 5 GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 5/1036 100/18670 0.6575 0.8548 0.7548 AUTS2/ATMIN/DYNLL1/HDAC4/ZMYND10 5 GO:0006720 isoprenoid metabolic process 7/1036 139/18670 0.6576 0.8548 0.7548 PDSS1/IDI1/LRP1/CYP2C9/AKR1B1/AKR1C3/RDH16 7 GO:0006310 DNA recombination 15/1036 292/18670 0.6584 0.8548 0.7548 PARP1/SFPQ/TNFSF13/PSMD14/WAS/MSH2/TBX21/INO80B/BCL11B/SETX/RPA1/XRCC2/CDC7/MCM6/POLQ 15 GO:0090287 regulation of cellular response to growth factor stimulus 15/1036 292/18670 0.6584 0.8548 0.7548 FKBP8/TGFBR2/IL1B/FLCN/TMEM204/HTRA1/TGFBR3/CYFIP2/SULF1/UBA52/STK11/CITED2/UBB/FGF18/ZBTB7A 15 GO:0021532 neural tube patterning 2/1036 40/18670 0.6589 0.8548 0.7548 FKBP8/PRKACB 2 GO:0032008 positive regulation of TOR signaling 2/1036 40/18670 0.6589 0.8548 0.7548 FLCN/PIK3CA 2 GO:0032467 positive regulation of cytokinesis 2/1036 40/18670 0.6589 0.8548 0.7548 AURKC/CDC25B 2 GO:0042026 protein refolding 2/1036 40/18670 0.6589 0.8548 0.7548 HSPA9/HSPA14 2 GO:0044058 regulation of digestive system process 2/1036 40/18670 0.6589 0.8548 0.7548 KCNQ1/NMU 2 GO:0045124 regulation of bone resorption 2/1036 40/18670 0.6589 0.8548 0.7548 CD38/IL6 2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2/1036 40/18670 0.6589 0.8548 0.7548 CXCL11/NTSR1 2 GO:0072210 metanephric nephron development 2/1036 40/18670 0.6589 0.8548 0.7548 LIF/SIX2 2 GO:0072583 clathrin-dependent endocytosis 2/1036 40/18670 0.6589 0.8548 0.7548 ITGA4/AP2B1 2 GO:0009749 response to glucose 10/1036 197/18670 0.6592 0.8548 0.7548 TRA2B/TGFBR2/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/TRH/GHRHR 10 GO:0010975 regulation of neuron projection development 26/1036 499/18670 0.6595 0.8548 0.7548 CD38/NCK1/ITGA6/ARHGAP4/CPNE6/FYN/CAPRIN2/CXCR4/PLXNB2/MAP2/LRP1/SEMA4G/DNM1L/TMEM106B/SEMA3G/STK11/DBN1/CAPRIN1/DSCAM/SETX/NTN1/ADNP/PAQR3/EFNB3/CRMP1/FEZ1 26 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 18/1036 349/18670 0.6601 0.8548 0.7548 FKBP8/PARP1/TGFBR2/FLCN/USP9Y/HTRA1/ACVR1/FNTA/TGFBR3/BMPR1B/SULF1/MAPK3/UBA52/STK11/CITED2/AMHR2/UBB/ZBTB7A 18 GO:2001257 regulation of cation channel activity 9/1036 178/18670 0.6604 0.8548 0.7548 IFNG/CLIC2/CAPN1/NTSR1/PDE4B/JPH3/CACNB4/KCNS1/EHD3 9 GO:0001573 ganglioside metabolic process 1/1036 19/18670 0.6622 0.8548 0.7548 ST3GAL5 1 GO:0001710 mesodermal cell fate commitment 1/1036 19/18670 0.6622 0.8548 0.7548 SIX2 1 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 1/1036 19/18670 0.6622 0.8548 0.7548 CTSG 1 GO:0002076 osteoblast development 1/1036 19/18670 0.6622 0.8548 0.7548 HDAC4 1 GO:0002710 negative regulation of T cell mediated immunity 1/1036 19/18670 0.6622 0.8548 0.7548 TBX21 1 GO:0003085 negative regulation of systemic arterial blood pressure 1/1036 19/18670 0.6622 0.8548 0.7548 NTSR1 1 GO:0003159 morphogenesis of an endothelium 1/1036 19/18670 0.6622 0.8548 0.7548 CXCR4 1 GO:0006044 N-acetylglucosamine metabolic process 1/1036 19/18670 0.6622 0.8548 0.7548 GNE 1 GO:0006337 nucleosome disassembly 1/1036 19/18670 0.6622 0.8548 0.7548 SMARCD3 1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process 1/1036 19/18670 0.6622 0.8548 0.7548 ALG13 1 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 1/1036 19/18670 0.6622 0.8548 0.7548 UCKL1 1 GO:0010985 negative regulation of lipoprotein particle clearance 1/1036 19/18670 0.6622 0.8548 0.7548 KHSRP 1 GO:0016074 snoRNA metabolic process 1/1036 19/18670 0.6622 0.8548 0.7548 FBL 1 GO:0016082 synaptic vesicle priming 1/1036 19/18670 0.6622 0.8548 0.7548 SV2A 1 GO:0030150 protein import into mitochondrial matrix 1/1036 19/18670 0.6622 0.8548 0.7548 TOMM20 1 GO:0030859 polarized epithelial cell differentiation 1/1036 19/18670 0.6622 0.8548 0.7548 SH3BP1 1 GO:0032011 ARF protein signal transduction 1/1036 19/18670 0.6622 0.8548 0.7548 IQSEC3 1 GO:0032012 regulation of ARF protein signal transduction 1/1036 19/18670 0.6622 0.8548 0.7548 IQSEC3 1 GO:0032288 myelin assembly 1/1036 19/18670 0.6622 0.8548 0.7548 CD9 1 GO:0032930 positive regulation of superoxide anion generation 1/1036 19/18670 0.6622 0.8548 0.7548 SOD1 1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 1/1036 19/18670 0.6622 0.8548 0.7548 ACSL3 1 GO:0035728 response to hepatocyte growth factor 1/1036 19/18670 0.6622 0.8548 0.7548 GCLC 1 GO:0036303 lymph vessel morphogenesis 1/1036 19/18670 0.6622 0.8548 0.7548 LGALS8 1 GO:0036342 post-anal tail morphogenesis 1/1036 19/18670 0.6622 0.8548 0.7548 TMED2 1 GO:0042693 muscle cell fate commitment 1/1036 19/18670 0.6622 0.8548 0.7548 ACVR1 1 GO:0045063 T-helper 1 cell differentiation 1/1036 19/18670 0.6622 0.8548 0.7548 ANXA1 1 GO:0048490 anterograde synaptic vesicle transport 1/1036 19/18670 0.6622 0.8548 0.7548 MAP2 1 GO:0060219 camera-type eye photoreceptor cell differentiation 1/1036 19/18670 0.6622 0.8548 0.7548 DSCAM 1 GO:0060457 negative regulation of digestive system process 1/1036 19/18670 0.6622 0.8548 0.7548 NMU 1 GO:0060716 labyrinthine layer blood vessel development 1/1036 19/18670 0.6622 0.8548 0.7548 TMED2 1 GO:0061154 endothelial tube morphogenesis 1/1036 19/18670 0.6622 0.8548 0.7548 CXCR4 1 GO:0070989 oxidative demethylation 1/1036 19/18670 0.6622 0.8548 0.7548 CYP2C9 1 GO:0071071 regulation of phospholipid biosynthetic process 1/1036 19/18670 0.6622 0.8548 0.7548 ACSL3 1 GO:0071435 potassium ion export 1/1036 19/18670 0.6622 0.8548 0.7548 KCNQ1 1 GO:0071731 response to nitric oxide 1/1036 19/18670 0.6622 0.8548 0.7548 MTR 1 GO:0071800 podosome assembly 1/1036 19/18670 0.6622 0.8548 0.7548 TNF 1 GO:0072576 liver morphogenesis 1/1036 19/18670 0.6622 0.8548 0.7548 XBP1 1 GO:0090201 negative regulation of release of cytochrome c from mitochondria 1/1036 19/18670 0.6622 0.8548 0.7548 PSMD10 1 GO:0097623 potassium ion export across plasma membrane 1/1036 19/18670 0.6622 0.8548 0.7548 KCNQ1 1 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential 1/1036 19/18670 0.6622 0.8548 0.7548 KCNQ1 1 GO:0099514 synaptic vesicle cytoskeletal transport 1/1036 19/18670 0.6622 0.8548 0.7548 MAP2 1 GO:0099517 synaptic vesicle transport along microtubule 1/1036 19/18670 0.6622 0.8548 0.7548 MAP2 1 GO:1901741 positive regulation of myoblast fusion 1/1036 19/18670 0.6622 0.8548 0.7548 EHD2 1 GO:1902074 response to salt 1/1036 19/18670 0.6622 0.8548 0.7548 DAXX 1 GO:1902170 cellular response to reactive nitrogen species 1/1036 19/18670 0.6622 0.8548 0.7548 MTR 1 GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA 1/1036 19/18670 0.6622 0.8548 0.7548 NCOR1 1 GO:1990182 exosomal secretion 1/1036 19/18670 0.6622 0.8548 0.7548 IFNG 1 GO:2000042 negative regulation of double-strand break repair via homologous recombination 1/1036 19/18670 0.6622 0.8548 0.7548 POLQ 1 GO:2000251 positive regulation of actin cytoskeleton reorganization 1/1036 19/18670 0.6622 0.8548 0.7548 HAX1 1 GO:2000831 regulation of steroid hormone secretion 1/1036 19/18670 0.6622 0.8548 0.7548 CRY1 1 GO:0017157 regulation of exocytosis 11/1036 217/18670 0.6644 0.8561 0.7559 IFNG/ATP2A2/P2RX1/MICAL1/ANXA1/DNM1L/RAB9A/SPHK2/CHRM2/CLASP1/BCR 11 GO:0014032 neural crest cell development 4/1036 81/18670 0.6646 0.8561 0.7559 ACVR1/SEMA4G/MAPK3/SEMA3G 4 GO:0021766 hippocampus development 4/1036 81/18670 0.6646 0.8561 0.7559 BTG2/RARA/ATAT1/FEZ1 4 GO:1903533 regulation of protein targeting 4/1036 81/18670 0.6646 0.8561 0.7559 FYN/CSNK2A2/HAX1/MFF 4 GO:0001837 epithelial to mesenchymal transition 7/1036 140/18670 0.6649 0.8561 0.7559 IL6/TGFBR2/IL1B/ACVR1/TGFBR3/CLASP1/ADAM15 7 GO:0035725 sodium ion transmembrane transport 7/1036 140/18670 0.6649 0.8561 0.7559 SCN10A/TRPM2/SLC8A2/GPD1L/ATP1B1/RANGRF/SLC20A1 7 GO:0072073 kidney epithelium development 7/1036 140/18670 0.6649 0.8561 0.7559 MYC/CAT/MAGED1/RARA/LIF/SIX2/ACAT1 7 GO:0007405 neuroblast proliferation 3/1036 61/18670 0.6654 0.8561 0.7559 PLXNB2/ARTN/SMARCD3 3 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 3/1036 61/18670 0.6654 0.8561 0.7559 BIRC3/TNF/PIAS4 3 GO:0016266 O-glycan processing 3/1036 61/18670 0.6654 0.8561 0.7559 MUC2/GALNT10/B3GNT2 3 GO:0042490 mechanoreceptor differentiation 3/1036 61/18670 0.6654 0.8561 0.7559 GABRB2/SOD1/FZD2 3 GO:0045604 regulation of epidermal cell differentiation 3/1036 61/18670 0.6654 0.8561 0.7559 PRKCH/ZFP36/NCOA3 3 GO:0071384 cellular response to corticosteroid stimulus 3/1036 61/18670 0.6654 0.8561 0.7559 ZFP36/ANXA1/AKR1C3 3 GO:1903902 positive regulation of viral life cycle 3/1036 61/18670 0.6654 0.8561 0.7559 CCL5/PABPC1/VPS37B 3 GO:0034440 lipid oxidation 5/1036 101/18670 0.6661 0.8567 0.7565 ABCD3/ACADM/ETFA/SCP2/ACAT1 5 GO:0006479 protein methylation 9/1036 179/18670 0.6669 0.8574 0.7571 AUTS2/CTR9/FBL/BTG2/TRMT112/PCMTD2/ATRX/GSPT1/SATB1 9 GO:0008213 protein alkylation 9/1036 179/18670 0.6669 0.8574 0.7571 AUTS2/CTR9/FBL/BTG2/TRMT112/PCMTD2/ATRX/GSPT1/SATB1 9 GO:0001704 formation of primary germ layer 6/1036 121/18670 0.6689 0.8589 0.7585 CTR9/ITGA4/ITGA7/ACVR1/ITGB4/SIX2 6 GO:0010811 positive regulation of cell-substrate adhesion 6/1036 121/18670 0.6689 0.8589 0.7585 C1QBP/ITGA6/ARHGEF7/EMP2/CCL25/CD3E 6 GO:0046718 viral entry into host cell 6/1036 121/18670 0.6689 0.8589 0.7585 SLAMF1/PTX3/NPC1/CXCR4/FCN1/EFNB3 6 GO:0006839 mitochondrial transport 13/1036 256/18670 0.669 0.8589 0.7585 SLC25A32/MOAP1/SLC25A5/GZMB/CSNK2A2/YWHAQ/CYC1/AGK/TOMM20/PMAIP1/HAX1/MFF/SLC35F6 13 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 13/1036 256/18670 0.669 0.8589 0.7585 CXCL11/CCR3/CHRM5/GNAS/PRKACB/RGS1/CHGA/ANXA1/HRH2/OR10H1/CHRM2/PTGER4/GHRHR 13 GO:0010955 negative regulation of protein processing 2/1036 41/18670 0.6722 0.8602 0.7596 BIRC3/CST7 2 GO:0021575 hindbrain morphogenesis 2/1036 41/18670 0.6722 0.8602 0.7596 RORA/HERC1 2 GO:0030890 positive regulation of B cell proliferation 2/1036 41/18670 0.6722 0.8602 0.7596 CD38/GPR183 2 GO:0034122 negative regulation of toll-like receptor signaling pathway 2/1036 41/18670 0.6722 0.8602 0.7596 TLR3/TLR6 2 GO:0035337 fatty-acyl-CoA metabolic process 2/1036 41/18670 0.6722 0.8602 0.7596 ACSL3/ACAT1 2 GO:0044091 membrane biogenesis 2/1036 41/18670 0.6722 0.8602 0.7596 EMP2/RFTN1 2 GO:0044743 protein transmembrane import into intracellular organelle 2/1036 41/18670 0.6722 0.8602 0.7596 AGK/TOMM20 2 GO:0050873 brown fat cell differentiation 2/1036 41/18670 0.6722 0.8602 0.7596 ITGA6/ZNF516 2 GO:0090279 regulation of calcium ion import 2/1036 41/18670 0.6722 0.8602 0.7596 FYN/SPHK2 2 GO:0090317 negative regulation of intracellular protein transport 2/1036 41/18670 0.6722 0.8602 0.7596 INSIG1/UBE2J1 2 GO:1901381 positive regulation of potassium ion transmembrane transport 2/1036 41/18670 0.6722 0.8602 0.7596 ATP1B1/KCNQ1 2 GO:1903170 negative regulation of calcium ion transmembrane transport 2/1036 41/18670 0.6722 0.8602 0.7596 CLIC2/NTSR1 2 GO:1903318 negative regulation of protein maturation 2/1036 41/18670 0.6722 0.8602 0.7596 BIRC3/CST7 2 GO:0008286 insulin receptor signaling pathway 7/1036 141/18670 0.6722 0.8602 0.7596 SOS1/IL1B/NCK1/PRKCQ/PIK3CA/PIK3C2A/PIK3R1 7 GO:0070613 regulation of protein processing 9/1036 180/18670 0.6734 0.8603 0.7597 IL1B/C1QBP/PRKACB/PLGRKT/BIRC3/F12/C8B/CST7/CD5L 9 GO:0060415 muscle tissue morphogenesis 4/1036 82/18670 0.674 0.8603 0.7597 TNNI1/TGFBR3/HEG1/FZD2 4 GO:0006900 vesicle budding from membrane 5/1036 102/18670 0.6746 0.8603 0.7597 CTSC/INSIG1/SCFD1/SEC24A/TMED2 5 GO:0048762 mesenchymal cell differentiation 11/1036 219/18670 0.6761 0.8603 0.7597 IL6/TGFBR2/IL1B/ACVR1/TGFBR3/SEMA4G/MAPK3/SEMA3G/CLASP1/ADAM15/SIX2 11 GO:0009880 embryonic pattern specification 3/1036 62/18670 0.6762 0.8603 0.7597 ZBTB16/PGAP1/TMED2 3 GO:0010830 regulation of myotube differentiation 3/1036 62/18670 0.6762 0.8603 0.7597 EHD2/XBP1/HDAC4 3 GO:0048857 neural nucleus development 3/1036 62/18670 0.6762 0.8603 0.7597 DYNLL1/YWHAQ/MBP 3 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 3/1036 62/18670 0.6762 0.8603 0.7597 NCK1/XBP1/PMAIP1 3 GO:1902305 regulation of sodium ion transmembrane transport 3/1036 62/18670 0.6762 0.8603 0.7597 GPD1L/ATP1B1/RANGRF 3 GO:1905268 negative regulation of chromatin organization 3/1036 62/18670 0.6762 0.8603 0.7597 SPHK2/SPI1/ATG5 3 GO:0006282 regulation of DNA repair 6/1036 122/18670 0.6766 0.8603 0.7597 PCNA/PARP1/USP1/WAS/CBX8/POLQ 6 GO:0043500 muscle adaptation 6/1036 122/18670 0.6766 0.8603 0.7597 PARP1/IL1B/ATP2A2/TNNI1/HDAC4/IL15 6 GO:0050890 cognition 15/1036 296/18670 0.6787 0.8603 0.7597 DDHD2/EIF4A3/BTG2/VDAC3/FYN/NTSR1/TNF/SLC12A5/ATP8A1/HRH2/SLC8A2/PRKAR2B/JPH3/CCL11/ADNP 15 GO:0048705 skeletal system morphogenesis 12/1036 239/18670 0.6806 0.8603 0.7597 ARID5B/TGFBR2/GNAS/INSIG1/EIF4A3/BMPR1B/HOXA6/PRKRA/RARA/OTOR/FGF18/SIX2 12 GO:0003215 cardiac right ventricle morphogenesis 1/1036 20/18670 0.6809 0.8603 0.7597 SMARCD3 1 GO:0006271 DNA strand elongation involved in DNA replication 1/1036 20/18670 0.6809 0.8603 0.7597 PCNA 1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 1/1036 20/18670 0.6809 0.8603 0.7597 ALG13 1 GO:0006525 arginine metabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 OTC 1 GO:0007095 mitotic G2 DNA damage checkpoint 1/1036 20/18670 0.6809 0.8603 0.7597 DONSON 1 GO:0008356 asymmetric cell division 1/1036 20/18670 0.6809 0.8603 0.7597 ZBTB16 1 GO:0009264 deoxyribonucleotide catabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 DERA 1 GO:0010560 positive regulation of glycoprotein biosynthetic process 1/1036 20/18670 0.6809 0.8603 0.7597 IL15 1 GO:0023019 signal transduction involved in regulation of gene expression 1/1036 20/18670 0.6809 0.8603 0.7597 PARP1 1 GO:0032211 negative regulation of telomere maintenance via telomerase 1/1036 20/18670 0.6809 0.8603 0.7597 TERF1 1 GO:0032495 response to muramyl dipeptide 1/1036 20/18670 0.6809 0.8603 0.7597 PTPN22 1 GO:0032769 negative regulation of monooxygenase activity 1/1036 20/18670 0.6809 0.8603 0.7597 NFKB1 1 GO:0032793 positive regulation of CREB transcription factor activity 1/1036 20/18670 0.6809 0.8603 0.7597 CRTC3 1 GO:0033005 positive regulation of mast cell activation 1/1036 20/18670 0.6809 0.8603 0.7597 SPHK2 1 GO:0033194 response to hydroperoxide 1/1036 20/18670 0.6809 0.8603 0.7597 CD38 1 GO:0035458 cellular response to interferon-beta 1/1036 20/18670 0.6809 0.8603 0.7597 TLR3 1 GO:0042053 regulation of dopamine metabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 ABAT 1 GO:0042069 regulation of catecholamine metabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 ABAT 1 GO:0043691 reverse cholesterol transport 1/1036 20/18670 0.6809 0.8603 0.7597 CETP 1 GO:0045019 negative regulation of nitric oxide biosynthetic process 1/1036 20/18670 0.6809 0.8603 0.7597 KHSRP 1 GO:0045655 regulation of monocyte differentiation 1/1036 20/18670 0.6809 0.8603 0.7597 MYC 1 GO:0046655 folic acid metabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 SLC25A32 1 GO:0048148 behavioral response to cocaine 1/1036 20/18670 0.6809 0.8603 0.7597 ABAT 1 GO:0048670 regulation of collateral sprouting 1/1036 20/18670 0.6809 0.8603 0.7597 LRP1 1 GO:0051016 barbed-end actin filament capping 1/1036 20/18670 0.6809 0.8603 0.7597 ADD3 1 GO:0051767 nitric-oxide synthase biosynthetic process 1/1036 20/18670 0.6809 0.8603 0.7597 IFNG 1 GO:0051769 regulation of nitric-oxide synthase biosynthetic process 1/1036 20/18670 0.6809 0.8603 0.7597 IFNG 1 GO:0051797 regulation of hair follicle development 1/1036 20/18670 0.6809 0.8603 0.7597 TNF 1 GO:0061162 establishment of monopolar cell polarity 1/1036 20/18670 0.6809 0.8603 0.7597 SH3BP1 1 GO:0086014 atrial cardiac muscle cell action potential 1/1036 20/18670 0.6809 0.8603 0.7597 KCNQ1 1 GO:0086026 atrial cardiac muscle cell to AV node cell signaling 1/1036 20/18670 0.6809 0.8603 0.7597 KCNQ1 1 GO:0086066 atrial cardiac muscle cell to AV node cell communication 1/1036 20/18670 0.6809 0.8603 0.7597 KCNQ1 1 GO:0097062 dendritic spine maintenance 1/1036 20/18670 0.6809 0.8603 0.7597 FYN 1 GO:0097503 sialylation 1/1036 20/18670 0.6809 0.8603 0.7597 ST3GAL5 1 GO:0097709 connective tissue replacement 1/1036 20/18670 0.6809 0.8603 0.7597 IL1A 1 GO:0097734 extracellular exosome biogenesis 1/1036 20/18670 0.6809 0.8603 0.7597 IFNG 1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/1036 20/18670 0.6809 0.8603 0.7597 XBP1 1 GO:1903599 positive regulation of autophagy of mitochondrion 1/1036 20/18670 0.6809 0.8603 0.7597 OPTN 1 GO:1904406 negative regulation of nitric oxide metabolic process 1/1036 20/18670 0.6809 0.8603 0.7597 KHSRP 1 GO:2000774 positive regulation of cellular senescence 1/1036 20/18670 0.6809 0.8603 0.7597 EEF1E1 1 GO:1901879 regulation of protein depolymerization 4/1036 83/18670 0.6833 0.863 0.7621 ADD3/CKAP2/CLASP1/SH3BP1 4 GO:0010559 regulation of glycoprotein biosynthetic process 2/1036 42/18670 0.6851 0.8638 0.7628 ITM2A/IL15 2 GO:0010907 positive regulation of glucose metabolic process 2/1036 42/18670 0.6851 0.8638 0.7628 DYRK2/PMAIP1 2 GO:0021983 pituitary gland development 2/1036 42/18670 0.6851 0.8638 0.7628 LHX3/GHRHR 2 GO:0044088 regulation of vacuole organization 2/1036 42/18670 0.6851 0.8638 0.7628 SCFD1/FEZ1 2 GO:0051154 negative regulation of striated muscle cell differentiation 2/1036 42/18670 0.6851 0.8638 0.7628 XBP1/HDAC4 2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 2/1036 42/18670 0.6851 0.8638 0.7628 REXO2/EXOSC8 2 GO:0099622 cardiac muscle cell membrane repolarization 2/1036 42/18670 0.6851 0.8638 0.7628 ATP1B1/KCNQ1 2 GO:1903317 regulation of protein maturation 9/1036 182/18670 0.686 0.8648 0.7637 IL1B/C1QBP/PRKACB/PLGRKT/BIRC3/F12/C8B/CST7/CD5L 9 GO:2000401 regulation of lymphocyte migration 3/1036 63/18670 0.6868 0.8656 0.7643 CCL5/MADCAM1/ITGA4 3 GO:1902600 proton transmembrane transport 8/1036 163/18670 0.6892 0.8677 0.7662 ATP2A2/COX6C/NNT/NDUFA4/PHB2/CYC1/SPHK2/CYB5A 8 GO:0009746 response to hexose 10/1036 202/18670 0.6896 0.8677 0.7662 TRA2B/TGFBR2/OXCT1/DYNLL1/GCLC/LRP1/XBP1/PIK3CA/TRH/GHRHR 10 GO:0010923 negative regulation of phosphatase activity 5/1036 104/18670 0.6911 0.8677 0.7662 PPP1R17/PPP1R8/TNF/PKMYT1/MPHOSPH10 5 GO:0014812 muscle cell migration 5/1036 104/18670 0.6911 0.8677 0.7662 CCL5/ANXA1/LRP1/PARVA/HDAC4 5 GO:0032414 positive regulation of ion transmembrane transporter activity 5/1036 104/18670 0.6911 0.8677 0.7662 ABCB1/IFNG/NTSR1/ATP1B1/EHD3 5 GO:0046928 regulation of neurotransmitter secretion 5/1036 104/18670 0.6911 0.8677 0.7662 ATP2A2/KMO/P2RX1/DNM1L/CHRM2 5 GO:0071887 leukocyte apoptotic process 5/1036 104/18670 0.6911 0.8677 0.7662 CCL5/IL6/PRKCQ/ANXA1/CLC 5 GO:0042593 glucose homeostasis 12/1036 241/18670 0.6915 0.8677 0.7662 TRA2B/OXCT1/DYNLL1/GCLC/CRY1/LRP1/XBP1/PIK3CA/STK11/HECTD4/GHRHR/PIK3R1 12 GO:0051101 regulation of DNA binding 6/1036 124/18670 0.6917 0.8677 0.7662 PARP1/IFNG/GZMA/LIF/TNKS/ZBTB7A 6 GO:0051492 regulation of stress fiber assembly 4/1036 84/18670 0.6923 0.8677 0.7662 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0006633 fatty acid biosynthetic process 8/1036 164/18670 0.6957 0.8677 0.7662 ABCD3/IL1B/INSIG1/ANXA1/XBP1/CYP2C9/AKR1C3/ACSL3 8 GO:0033500 carbohydrate homeostasis 12/1036 242/18670 0.6969 0.8677 0.7662 TRA2B/OXCT1/DYNLL1/GCLC/CRY1/LRP1/XBP1/PIK3CA/STK11/HECTD4/GHRHR/PIK3R1 12 GO:0035773 insulin secretion involved in cellular response to glucose stimulus 3/1036 64/18670 0.697 0.8677 0.7662 OXCT1/DYNLL1/LRP1 3 GO:0036498 IRE1-mediated unfolded protein response 3/1036 64/18670 0.697 0.8677 0.7662 XBP1/EDEM1/GFPT1 3 GO:0044783 G1 DNA damage checkpoint 3/1036 64/18670 0.697 0.8677 0.7662 PCNA/BTG2/WAC 3 GO:0048278 vesicle docking 3/1036 64/18670 0.697 0.8677 0.7662 SCFD1/STX10/STX8 3 GO:1900449 regulation of glutamate receptor signaling pathway 3/1036 64/18670 0.697 0.8677 0.7662 IFNG/CAPN1/FYN 3 GO:1903672 positive regulation of sprouting angiogenesis 3/1036 64/18670 0.697 0.8677 0.7662 PPP1R16B/ANXA1/PIK3C2A 3 GO:0003009 skeletal muscle contraction 2/1036 43/18670 0.6975 0.8677 0.7662 SYNM/ATP2A2 2 GO:0031279 regulation of cyclase activity 2/1036 43/18670 0.6975 0.8677 0.7662 MAPK3/TIMP2 2 GO:0032459 regulation of protein oligomerization 2/1036 43/18670 0.6975 0.8677 0.7662 DNM1L/PMAIP1 2 GO:0032924 activin receptor signaling pathway 2/1036 43/18670 0.6975 0.8677 0.7662 ACVR1/CITED2 2 GO:0043616 keratinocyte proliferation 2/1036 43/18670 0.6975 0.8677 0.7662 ZFP36/BCL11B 2 GO:0046461 neutral lipid catabolic process 2/1036 43/18670 0.6975 0.8677 0.7662 DDHD2/LIPE 2 GO:0046464 acylglycerol catabolic process 2/1036 43/18670 0.6975 0.8677 0.7662 DDHD2/LIPE 2 GO:0051293 establishment of spindle localization 2/1036 43/18670 0.6975 0.8677 0.7662 NDC80/CLASP1 2 GO:0051602 response to electrical stimulus 2/1036 43/18670 0.6975 0.8677 0.7662 BTG2/BRD1 2 GO:0070296 sarcoplasmic reticulum calcium ion transport 2/1036 43/18670 0.6975 0.8677 0.7662 CLIC2/ATP2A2 2 GO:0071364 cellular response to epidermal growth factor stimulus 2/1036 43/18670 0.6975 0.8677 0.7662 ZFP36/PDE8A 2 GO:1990573 potassium ion import across plasma membrane 2/1036 43/18670 0.6975 0.8677 0.7662 SLC12A5/ATP1B1 2 GO:0050864 regulation of B cell activation 9/1036 184/18670 0.6983 0.8677 0.7662 CD38/IL6/TNFSF13/MSH2/TBX21/XBP1/GPR183/SLAMF8/TRBC1 9 GO:0002115 store-operated calcium entry 1/1036 21/18670 0.6987 0.8677 0.7662 ORAI3 1 GO:0002438 acute inflammatory response to antigenic stimulus 1/1036 21/18670 0.6987 0.8677 0.7662 ELANE 1 GO:0003283 atrial septum development 1/1036 21/18670 0.6987 0.8677 0.7662 ACVR1 1 GO:0006067 ethanol metabolic process 1/1036 21/18670 0.6987 0.8677 0.7662 ALDH3B1 1 GO:0016553 base conversion or substitution editing 1/1036 21/18670 0.6987 0.8677 0.7662 APOBEC3G 1 GO:0019682 glyceraldehyde-3-phosphate metabolic process 1/1036 21/18670 0.6987 0.8677 0.7662 DERA 1 GO:0030277 maintenance of gastrointestinal epithelium 1/1036 21/18670 0.6987 0.8677 0.7662 MUC2 1 GO:0031290 retinal ganglion cell axon guidance 1/1036 21/18670 0.6987 0.8677 0.7662 BMPR1B 1 GO:0031498 chromatin disassembly 1/1036 21/18670 0.6987 0.8677 0.7662 SMARCD3 1 GO:0032674 regulation of interleukin-5 production 1/1036 21/18670 0.6987 0.8677 0.7662 RARA 1 GO:0034389 lipid droplet organization 1/1036 21/18670 0.6987 0.8677 0.7662 DDHD2 1 GO:0036120 cellular response to platelet-derived growth factor stimulus 1/1036 21/18670 0.6987 0.8677 0.7662 FYN 1 GO:0039702 viral budding via host ESCRT complex 1/1036 21/18670 0.6987 0.8677 0.7662 VPS37B 1 GO:0042135 neurotransmitter catabolic process 1/1036 21/18670 0.6987 0.8677 0.7662 ABAT 1 GO:0046386 deoxyribose phosphate catabolic process 1/1036 21/18670 0.6987 0.8677 0.7662 DERA 1 GO:0046716 muscle cell cellular homeostasis 1/1036 21/18670 0.6987 0.8677 0.7662 SOD1 1 GO:0051412 response to corticosterone 1/1036 21/18670 0.6987 0.8677 0.7662 TRH 1 GO:0055093 response to hyperoxia 1/1036 21/18670 0.6987 0.8677 0.7662 CAT 1 GO:0060044 negative regulation of cardiac muscle cell proliferation 1/1036 21/18670 0.6987 0.8677 0.7662 TGFBR2 1 GO:0060713 labyrinthine layer morphogenesis 1/1036 21/18670 0.6987 0.8677 0.7662 SPINT1 1 GO:0061213 positive regulation of mesonephros development 1/1036 21/18670 0.6987 0.8677 0.7662 MAGED1 1 GO:0061339 establishment or maintenance of monopolar cell polarity 1/1036 21/18670 0.6987 0.8677 0.7662 SH3BP1 1 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA 1/1036 21/18670 0.6987 0.8677 0.7662 NCOR1 1 GO:0071459 protein localization to chromosome, centromeric region 1/1036 21/18670 0.6987 0.8677 0.7662 NDC80 1 GO:0090280 positive regulation of calcium ion import 1/1036 21/18670 0.6987 0.8677 0.7662 SPHK2 1 GO:0140131 positive regulation of lymphocyte chemotaxis 1/1036 21/18670 0.6987 0.8677 0.7662 CCL5 1 GO:1901739 regulation of myoblast fusion 1/1036 21/18670 0.6987 0.8677 0.7662 EHD2 1 GO:1902307 positive regulation of sodium ion transmembrane transport 1/1036 21/18670 0.6987 0.8677 0.7662 ATP1B1 1 GO:1903392 negative regulation of adherens junction organization 1/1036 21/18670 0.6987 0.8677 0.7662 LRP1 1 GO:1904469 positive regulation of tumor necrosis factor secretion 1/1036 21/18670 0.6987 0.8677 0.7662 IFNG 1 GO:1904886 beta-catenin destruction complex disassembly 1/1036 21/18670 0.6987 0.8677 0.7662 FZD2 1 GO:2000738 positive regulation of stem cell differentiation 1/1036 21/18670 0.6987 0.8677 0.7662 NUDT21 1 GO:0006805 xenobiotic metabolic process 6/1036 125/18670 0.6991 0.8679 0.7664 CRYZ/RORA/AKR7A2/CYP2C9/MARC1/GSTA3 6 GO:0032006 regulation of TOR signaling 5/1036 105/18670 0.6992 0.8679 0.7664 FLCN/SESN1/PIK3CA/STK11/DYRK3 5 GO:0000077 DNA damage checkpoint 7/1036 145/18670 0.7002 0.869 0.7674 PCNA/BTG2/CRY1/MSH2/ATR/WAC/DONSON 7 GO:0015850 organic hydroxy compound transport 13/1036 262/18670 0.7006 0.8693 0.7676 ABAT/NFKB1/CHRM5/CETP/LDLRAP1/NPC1/P2RX1/CHGA/LRP1/SLC10A2/SCP2/PON1/PGAP1 13 GO:0014031 mesenchymal cell development 4/1036 85/18670 0.7012 0.8694 0.7677 ACVR1/SEMA4G/MAPK3/SEMA3G 4 GO:0045682 regulation of epidermis development 4/1036 85/18670 0.7012 0.8694 0.7677 PRKCH/ZFP36/TNF/NCOA3 4 GO:0048864 stem cell development 4/1036 85/18670 0.7012 0.8694 0.7677 ACVR1/SEMA4G/MAPK3/SEMA3G 4 GO:0050680 negative regulation of epithelial cell proliferation 8/1036 165/18670 0.7021 0.8703 0.7685 WFDC1/MAGED1/TNF/TGFBR3/PHB2/SULF1/AIMP1/STK11 8 GO:0050678 regulation of epithelial cell proliferation 19/1036 378/18670 0.7052 0.8739 0.7717 MYC/CCL5/CCR3/PPP1R16B/ITGA4/WFDC1/ZFP36/HTRA1/MAGED1/TNF/TGFBR3/PHB2/BCL11B/XBP1/SULF1/HMGN1/AIMP1/STK11/CCL11 19 GO:0031060 regulation of histone methylation 3/1036 65/18670 0.707 0.8748 0.7725 AUTS2/CTR9/ATRX 3 GO:0048663 neuron fate commitment 3/1036 65/18670 0.707 0.8748 0.7725 LHX3/BCL11B/TLX3 3 GO:0051148 negative regulation of muscle cell differentiation 3/1036 65/18670 0.707 0.8748 0.7725 ANKRD17/XBP1/HDAC4 3 GO:0060389 pathway-restricted SMAD protein phosphorylation 3/1036 65/18670 0.707 0.8748 0.7725 TGFBR2/ACVR1/TGFBR3 3 GO:0060675 ureteric bud morphogenesis 3/1036 65/18670 0.707 0.8748 0.7725 MYC/MAGED1/SIX2 3 GO:0070192 chromosome organization involved in meiotic cell cycle 3/1036 65/18670 0.707 0.8748 0.7725 ATRX/TERF1/SMC2 3 GO:0072577 endothelial cell apoptotic process 3/1036 65/18670 0.707 0.8748 0.7725 ITGA4/TNF/AKR1C3 3 GO:0003416 endochondral bone growth 2/1036 44/18670 0.7096 0.8759 0.7734 TGFBR2/RARA 2 GO:0007007 inner mitochondrial membrane organization 2/1036 44/18670 0.7096 0.8759 0.7734 AGK/CHCHD3 2 GO:0018023 peptidyl-lysine trimethylation 2/1036 44/18670 0.7096 0.8759 0.7734 CTR9/ATRX 2 GO:0032965 regulation of collagen biosynthetic process 2/1036 44/18670 0.7096 0.8759 0.7734 IL6/CBX8 2 GO:0045601 regulation of endothelial cell differentiation 2/1036 44/18670 0.7096 0.8759 0.7734 IL1B/TNF 2 GO:0045910 negative regulation of DNA recombination 2/1036 44/18670 0.7096 0.8759 0.7734 MSH2/POLQ 2 GO:0051489 regulation of filopodium assembly 2/1036 44/18670 0.7096 0.8759 0.7734 PPP1R16B/TRPM2 2 GO:1903214 regulation of protein targeting to mitochondrion 2/1036 44/18670 0.7096 0.8759 0.7734 CSNK2A2/HAX1 2 GO:2000404 regulation of T cell migration 2/1036 44/18670 0.7096 0.8759 0.7734 CCL5/ITGA4 2 GO:0001942 hair follicle development 4/1036 86/18670 0.7099 0.8759 0.7734 SOS1/TNF/TGM3/SOX21 4 GO:0002052 positive regulation of neuroblast proliferation 1/1036 22/18670 0.7154 0.8759 0.7734 SMARCD3 1 GO:0002097 tRNA wobble base modification 1/1036 22/18670 0.7154 0.8759 0.7734 MTO1 1 GO:0005980 glycogen catabolic process 1/1036 22/18670 0.7154 0.8759 0.7734 PHKG1 1 GO:0007289 spermatid nucleus differentiation 1/1036 22/18670 0.7154 0.8759 0.7734 PSME4 1 GO:0010842 retina layer formation 1/1036 22/18670 0.7154 0.8759 0.7734 DSCAM 1 GO:0010884 positive regulation of lipid storage 1/1036 22/18670 0.7154 0.8759 0.7734 NFKB1 1 GO:0018230 peptidyl-L-cysteine S-palmitoylation 1/1036 22/18670 0.7154 0.8759 0.7734 ZDHHC4 1 GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1/1036 22/18670 0.7154 0.8759 0.7734 ZDHHC4 1 GO:0021513 spinal cord dorsal/ventral patterning 1/1036 22/18670 0.7154 0.8759 0.7734 LHX3 1 GO:0021854 hypothalamus development 1/1036 22/18670 0.7154 0.8759 0.7734 UBB 1 GO:0030878 thyroid gland development 1/1036 22/18670 0.7154 0.8759 0.7734 MAPK3 1 GO:0032469 endoplasmic reticulum calcium ion homeostasis 1/1036 22/18670 0.7154 0.8759 0.7734 ATP2A2 1 GO:0032634 interleukin-5 production 1/1036 22/18670 0.7154 0.8759 0.7734 RARA 1 GO:0032656 regulation of interleukin-13 production 1/1036 22/18670 0.7154 0.8759 0.7734 RARA 1 GO:0032727 positive regulation of interferon-alpha production 1/1036 22/18670 0.7154 0.8759 0.7734 TLR3 1 GO:0032928 regulation of superoxide anion generation 1/1036 22/18670 0.7154 0.8759 0.7734 SOD1 1 GO:0033622 integrin activation 1/1036 22/18670 0.7154 0.8759 0.7734 PTGER4 1 GO:0035584 calcium-mediated signaling using intracellular calcium source 1/1036 22/18670 0.7154 0.8759 0.7734 TRPM2 1 GO:0035809 regulation of urine volume 1/1036 22/18670 0.7154 0.8759 0.7734 AKR1B1 1 GO:0035929 steroid hormone secretion 1/1036 22/18670 0.7154 0.8759 0.7734 CRY1 1 GO:0036119 response to platelet-derived growth factor 1/1036 22/18670 0.7154 0.8759 0.7734 FYN 1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1/1036 22/18670 0.7154 0.8759 0.7734 SULF1 1 GO:0045649 regulation of macrophage differentiation 1/1036 22/18670 0.7154 0.8759 0.7734 LIF 1 GO:0045717 negative regulation of fatty acid biosynthetic process 1/1036 22/18670 0.7154 0.8759 0.7734 INSIG1 1 GO:0045943 positive regulation of transcription by RNA polymerase I 1/1036 22/18670 0.7154 0.8759 0.7734 NOL11 1 GO:0050765 negative regulation of phagocytosis 1/1036 22/18670 0.7154 0.8759 0.7734 ATG5 1 GO:0051000 positive regulation of nitric-oxide synthase activity 1/1036 22/18670 0.7154 0.8759 0.7734 TNF 1 GO:0060390 regulation of SMAD protein signal transduction 1/1036 22/18670 0.7154 0.8759 0.7734 PARP1 1 GO:0060547 negative regulation of necrotic cell death 1/1036 22/18670 0.7154 0.8759 0.7734 BIRC3 1 GO:0097320 plasma membrane tubulation 1/1036 22/18670 0.7154 0.8759 0.7734 EHD2 1 GO:0140112 extracellular vesicle biogenesis 1/1036 22/18670 0.7154 0.8759 0.7734 IFNG 1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 1/1036 22/18670 0.7154 0.8759 0.7734 XBP1 1 GO:1901685 glutathione derivative metabolic process 1/1036 22/18670 0.7154 0.8759 0.7734 GSTA3 1 GO:1901687 glutathione derivative biosynthetic process 1/1036 22/18670 0.7154 0.8759 0.7734 GSTA3 1 GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1036 22/18670 0.7154 0.8759 0.7734 PPP1R16B 1 GO:2000773 negative regulation of cellular senescence 1/1036 22/18670 0.7154 0.8759 0.7734 FBXO5 1 GO:0010256 endomembrane system organization 22/1036 438/18670 0.7166 0.8768 0.7742 OPTN/ATP2A2/CXCR4/GORASP2/EHD2/SYNE1/ARHGEF7/PARP11/MAPK3/GOLGA8N/KIFC3/VRK1/GOLGA8A/CLASP1/VPS51/TMEM43/VPS37B/EHD3/SOD1/PLA2G3/TOR1AIP1/TMED2 22 GO:0040014 regulation of multicellular organism growth 3/1036 66/18670 0.7168 0.8768 0.7742 PIK3CA/GHRHR/SOD1 3 GO:0072171 mesonephric tubule morphogenesis 3/1036 66/18670 0.7168 0.8768 0.7742 MYC/MAGED1/SIX2 3 GO:1901880 negative regulation of protein depolymerization 3/1036 66/18670 0.7168 0.8768 0.7742 ADD3/CKAP2/CLASP1 3 GO:0030900 forebrain development 19/1036 381/18670 0.7178 0.8777 0.7751 TRA2B/BTG2/FYN/CXCR4/LHX3/CSNK2A2/LRP1/DNAJB1/BCL11B/RARA/PCM1/ATAT1/GHRHR/UBB/ATRX/PGAP1/SLC38A2/TMEM14B/FEZ1 19 GO:0001892 embryonic placenta development 4/1036 87/18670 0.7184 0.8783 0.7756 SPINT1/LIF/BPTF/TMED2 4 GO:0035148 tube formation 7/1036 148/18670 0.7202 0.8803 0.7774 PRKACB/RPS7/PLXNB2/SPINT1/RARA/FZD2/TMED2 7 GO:0001894 tissue homeostasis 11/1036 227/18670 0.7205 0.8803 0.7774 CD38/IL6/LYZ/LIPA/GNAS/MUC2/AKR1B1/STK11/FH/SOD1/RCN3 11 GO:0031018 endocrine pancreas development 2/1036 45/18670 0.7212 0.8803 0.7774 IL6/ANXA1 2 GO:0032570 response to progesterone 2/1036 45/18670 0.7212 0.8803 0.7774 CD38/CATSPERG 2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2/1036 45/18670 0.7212 0.8803 0.7774 DYRK2/MSH2 2 GO:0044275 cellular carbohydrate catabolic process 2/1036 45/18670 0.7212 0.8803 0.7774 ENOSF1/PHKG1 2 GO:0045581 negative regulation of T cell differentiation 2/1036 45/18670 0.7212 0.8803 0.7774 ANXA1/TBX21 2 GO:0015696 ammonium transport 5/1036 108/18670 0.7224 0.8814 0.7783 ABAT/CHRM5/P2RX1/RHAG/SLC38A2 5 GO:0032526 response to retinoic acid 5/1036 108/18670 0.7224 0.8814 0.7783 CD38/PHB2/CLK2/RARA/SETX 5 GO:0003143 embryonic heart tube morphogenesis 3/1036 67/18670 0.7263 0.8834 0.7801 TGFBR2/ACVR1/TMED2 3 GO:0030858 positive regulation of epithelial cell differentiation 3/1036 67/18670 0.7263 0.8834 0.7801 PRKCH/NCOA3/LIF 3 GO:0048662 negative regulation of smooth muscle cell proliferation 3/1036 67/18670 0.7263 0.8834 0.7801 IFNG/IL12B/IL15 3 GO:0051298 centrosome duplication 3/1036 67/18670 0.7263 0.8834 0.7801 TRIM37/NPM1/CEP76 3 GO:0051705 multi-organism behavior 3/1036 67/18670 0.7263 0.8834 0.7801 UBE2Q1/GNB1L/PCM1 3 GO:0032088 negative regulation of NF-kappaB transcription factor activity 4/1036 88/18670 0.7267 0.8834 0.7801 CAT/TRIM37/PIAS4/PSMD10 4 GO:0098773 skin epidermis development 4/1036 88/18670 0.7267 0.8834 0.7801 SOS1/TNF/TGM3/SOX21 4 GO:1901888 regulation of cell junction assembly 4/1036 88/18670 0.7267 0.8834 0.7801 PRKCH/TNF/LRP1/CLASP1 4 GO:2000177 regulation of neural precursor cell proliferation 4/1036 88/18670 0.7267 0.8834 0.7801 BTG2/NAP1L1/SMARCD3/SPINT1 4 GO:0008154 actin polymerization or depolymerization 10/1036 209/18670 0.7292 0.8834 0.7801 NCK1/RASA1/ADD3/MICAL1/WAS/PSTPIP1/CCL11/DBN1/HAX1/SH3BP1 10 GO:0035303 regulation of dephosphorylation 10/1036 209/18670 0.7292 0.8834 0.7801 PPP1R17/IFNG/PPP1R16B/PPP2R5C/CHRM5/PPP1R8/TNF/IGBP1/PKMYT1/MPHOSPH10 10 GO:0006493 protein O-linked glycosylation 5/1036 109/18670 0.7299 0.8834 0.7801 POGLUT1/MUC2/IL15/GALNT10/B3GNT2 5 GO:0021761 limbic system development 5/1036 109/18670 0.7299 0.8834 0.7801 BTG2/RARA/ATAT1/UBB/FEZ1 5 GO:0072009 nephron epithelium development 5/1036 109/18670 0.7299 0.8834 0.7801 MYC/MAGED1/LIF/SIX2/ACAT1 5 GO:0034249 negative regulation of cellular amide metabolic process 11/1036 229/18670 0.731 0.8834 0.7801 EIF4A3/BTG2/ZFP36/CAPRIN2/TIA1/HNRNPR/PUM1/RARA/CAPRIN1/KHSRP/FXR1 11 GO:0009068 aspartate family amino acid catabolic process 1/1036 23/18670 0.7312 0.8834 0.7801 DLD 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process 1/1036 23/18670 0.7312 0.8834 0.7801 UCKL1 1 GO:0009251 glucan catabolic process 1/1036 23/18670 0.7312 0.8834 0.7801 PHKG1 1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 1/1036 23/18670 0.7312 0.8834 0.7801 CLDN15 1 GO:0019400 alditol metabolic process 1/1036 23/18670 0.7312 0.8834 0.7801 AKR1B1 1 GO:0035561 regulation of chromatin binding 1/1036 23/18670 0.7312 0.8834 0.7801 GMNN 1 GO:0042401 cellular biogenic amine biosynthetic process 1/1036 23/18670 0.7312 0.8834 0.7801 ODC1 1 GO:0042451 purine nucleoside biosynthetic process 1/1036 23/18670 0.7312 0.8834 0.7801 APRT 1 GO:0042776 mitochondrial ATP synthesis coupled proton transport 1/1036 23/18670 0.7312 0.8834 0.7801 CYC1 1 GO:0045109 intermediate filament organization 1/1036 23/18670 0.7312 0.8834 0.7801 KRT9 1 GO:0045821 positive regulation of glycolytic process 1/1036 23/18670 0.7312 0.8834 0.7801 IFNG 1 GO:0046129 purine ribonucleoside biosynthetic process 1/1036 23/18670 0.7312 0.8834 0.7801 APRT 1 GO:0048714 positive regulation of oligodendrocyte differentiation 1/1036 23/18670 0.7312 0.8834 0.7801 CXCR4 1 GO:0051151 negative regulation of smooth muscle cell differentiation 1/1036 23/18670 0.7312 0.8834 0.7801 ANKRD17 1 GO:0051152 positive regulation of smooth muscle cell differentiation 1/1036 23/18670 0.7312 0.8834 0.7801 SMARCD3 1 GO:0051349 positive regulation of lyase activity 1/1036 23/18670 0.7312 0.8834 0.7801 TIMP2 1 GO:0051570 regulation of histone H3-K9 methylation 1/1036 23/18670 0.7312 0.8834 0.7801 ATRX 1 GO:0051589 negative regulation of neurotransmitter transport 1/1036 23/18670 0.7312 0.8834 0.7801 ABAT 1 GO:0060445 branching involved in salivary gland morphogenesis 1/1036 23/18670 0.7312 0.8834 0.7801 TNF 1 GO:0071467 cellular response to pH 1/1036 23/18670 0.7312 0.8834 0.7801 MCOLN1 1 GO:0086012 membrane depolarization during cardiac muscle cell action potential 1/1036 23/18670 0.7312 0.8834 0.7801 RANGRF 1 GO:0090343 positive regulation of cell aging 1/1036 23/18670 0.7312 0.8834 0.7801 EEF1E1 1 GO:0097150 neuronal stem cell population maintenance 1/1036 23/18670 0.7312 0.8834 0.7801 PCM1 1 GO:1901032 negative regulation of response to reactive oxygen species 1/1036 23/18670 0.7312 0.8834 0.7801 PDE8A 1 GO:1902259 regulation of delayed rectifier potassium channel activity 1/1036 23/18670 0.7312 0.8834 0.7801 KCNS1 1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 1/1036 23/18670 0.7312 0.8834 0.7801 PDE8A 1 GO:2001039 negative regulation of cellular response to drug 1/1036 23/18670 0.7312 0.8834 0.7801 PDE8A 1 GO:0001754 eye photoreceptor cell differentiation 2/1036 46/18670 0.7325 0.8834 0.7801 DSCAM/TRPM1 2 GO:0019731 antibacterial humoral response 2/1036 46/18670 0.7325 0.8834 0.7801 ELANE/CTSG 2 GO:0022602 ovulation cycle process 2/1036 46/18670 0.7325 0.8834 0.7801 PTX3/BMPR1B 2 GO:0032369 negative regulation of lipid transport 2/1036 46/18670 0.7325 0.8834 0.7801 NFKB1/CRY1 2 GO:0033628 regulation of cell adhesion mediated by integrin 2/1036 46/18670 0.7325 0.8834 0.7801 CCL5/CD3E 2 GO:0043300 regulation of leukocyte degranulation 2/1036 46/18670 0.7325 0.8834 0.7801 SPHK2/BCR 2 GO:0045776 negative regulation of blood pressure 2/1036 46/18670 0.7325 0.8834 0.7801 ABAT/NTSR1 2 GO:0060711 labyrinthine layer development 2/1036 46/18670 0.7325 0.8834 0.7801 SPINT1/TMED2 2 GO:1900015 regulation of cytokine production involved in inflammatory response 2/1036 46/18670 0.7325 0.8834 0.7801 TLR6/IL17B 2 GO:0042157 lipoprotein metabolic process 6/1036 130/18670 0.7342 0.8853 0.7818 ZDHHC4/APOL3/CTSD/LRP1/PGAP1/ATG5 6 GO:0032465 regulation of cytokinesis 4/1036 89/18670 0.7349 0.8859 0.7823 FLCN/AURKC/CDC25B/PRC1 4 GO:0050918 positive chemotaxis 3/1036 68/18670 0.7355 0.8865 0.7828 CCL5/ARTN/LRP1 3 GO:0001935 endothelial cell proliferation 9/1036 191/18670 0.739 0.8885 0.7845 CCR3/PPP1R16B/ITGA4/TNF/PRKX/XBP1/SULF1/AIMP1/CCL11 9 GO:1902850 microtubule cytoskeleton organization involved in mitosis 6/1036 131/18670 0.7409 0.8885 0.7845 KIF2A/AURKC/NDC80/TNKS/CLASP1/PRC1 6 GO:0034765 regulation of ion transmembrane transport 24/1036 483/18670 0.7418 0.8885 0.7845 CXCL11/ABCB1/IFNG/CLIC2/CAPN1/FYN/NTSR1/PDE4B/SCN10A/YWHAQ/PHB2/GPD1L/ATP1B1/SPHK2/KCNH1/JPH3/KCNC3/CACNB4/RANGRF/TSPAN13/KCNS1/EHD3/KCNQ1/ATG5 24 GO:0034330 cell junction organization 14/1036 290/18670 0.7419 0.8885 0.7845 FLCN/PRKCH/ITGA6/TNF/LRP1/ARHGEF7/ACTN1/KIFC3/CLASP1/CD9/HEG1/ITGB4/SH3BP1/BCR 14 GO:0014033 neural crest cell differentiation 4/1036 90/18670 0.7428 0.8885 0.7845 ACVR1/SEMA4G/MAPK3/SEMA3G 4 GO:0015844 monoamine transport 4/1036 90/18670 0.7428 0.8885 0.7845 ABAT/CHRM5/P2RX1/CHGA 4 GO:0030901 midbrain development 4/1036 90/18670 0.7428 0.8885 0.7845 SOS1/DYNLL1/YWHAQ/MBP 4 GO:0021695 cerebellar cortex development 2/1036 47/18670 0.7433 0.8885 0.7845 RORA/HERC1 2 GO:0030261 chromosome condensation 2/1036 47/18670 0.7433 0.8885 0.7845 NCAPG2/SMC2 2 GO:0060351 cartilage development involved in endochondral bone morphogenesis 2/1036 47/18670 0.7433 0.8885 0.7845 TGFBR2/RARA 2 GO:0098868 bone growth 2/1036 47/18670 0.7433 0.8885 0.7845 TGFBR2/RARA 2 GO:1900744 regulation of p38MAPK cascade 2/1036 47/18670 0.7433 0.8885 0.7845 IL1B/PTPN22 2 GO:1903580 positive regulation of ATP metabolic process 2/1036 47/18670 0.7433 0.8885 0.7845 PGK1/IFNG 2 GO:2000107 negative regulation of leukocyte apoptotic process 2/1036 47/18670 0.7433 0.8885 0.7845 CCL5/PRKCQ 2 GO:0055008 cardiac muscle tissue morphogenesis 3/1036 69/18670 0.7445 0.8885 0.7845 TNNI1/TGFBR3/HEG1 3 GO:0070227 lymphocyte apoptotic process 3/1036 69/18670 0.7445 0.8885 0.7845 CCL5/PRKCQ/CLC 3 GO:0071300 cellular response to retinoic acid 3/1036 69/18670 0.7445 0.8885 0.7845 PHB2/RARA/SETX 3 GO:0086003 cardiac muscle cell contraction 3/1036 69/18670 0.7445 0.8885 0.7845 PDE4B/GPD1L/KCNQ1 3 GO:0048489 synaptic vesicle transport 7/1036 152/18670 0.7454 0.8885 0.7845 ATP2A2/TMEM230/P2RX1/SV2A/MAP2/DNM1L/CHRM2 7 GO:0097480 establishment of synaptic vesicle localization 7/1036 152/18670 0.7454 0.8885 0.7845 ATP2A2/TMEM230/P2RX1/SV2A/MAP2/DNM1L/CHRM2 7 GO:0032970 regulation of actin filament-based process 19/1036 388/18670 0.7459 0.8885 0.7845 RHOH/NCK1/ARHGAP17/RASA1/ADD3/ATP2A2/PDE4B/TRPM2/WAS/CD2AP/LRP1/RANGRF/CCL11/PTGER4/CLASP1/DBN1/HAX1/SH3BP1/PIK3R1 19 GO:0003418 growth plate cartilage chondrocyte differentiation 1/1036 24/18670 0.7461 0.8885 0.7845 TGFBR2 1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis 1/1036 24/18670 0.7461 0.8885 0.7845 TGFBR2 1 GO:0009309 amine biosynthetic process 1/1036 24/18670 0.7461 0.8885 0.7845 ODC1 1 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway 1/1036 24/18670 0.7461 0.8885 0.7845 PIAS4 1 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1/1036 24/18670 0.7461 0.8885 0.7845 CLIC2 1 GO:0018126 protein hydroxylation 1/1036 24/18670 0.7461 0.8885 0.7845 PLOD1 1 GO:0021511 spinal cord patterning 1/1036 24/18670 0.7461 0.8885 0.7845 LHX3 1 GO:0021544 subpallium development 1/1036 24/18670 0.7461 0.8885 0.7845 BCL11B 1 GO:0032528 microvillus organization 1/1036 24/18670 0.7461 0.8885 0.7845 RAPGEF6 1 GO:0032925 regulation of activin receptor signaling pathway 1/1036 24/18670 0.7461 0.8885 0.7845 ACVR1 1 GO:0034162 toll-like receptor 9 signaling pathway 1/1036 24/18670 0.7461 0.8885 0.7845 RSAD2 1 GO:0036010 protein localization to endosome 1/1036 24/18670 0.7461 0.8885 0.7845 TOLLIP 1 GO:0042738 exogenous drug catabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 CYP2C9 1 GO:0042832 defense response to protozoan 1/1036 24/18670 0.7461 0.8885 0.7845 IL12B 1 GO:0043302 positive regulation of leukocyte degranulation 1/1036 24/18670 0.7461 0.8885 0.7845 SPHK2 1 GO:0046135 pyrimidine nucleoside catabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 APOBEC3G 1 GO:0046174 polyol catabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 NTSR1 1 GO:0046835 carbohydrate phosphorylation 1/1036 24/18670 0.7461 0.8885 0.7845 GNE 1 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 TPST1 1 GO:0050996 positive regulation of lipid catabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 IL1B 1 GO:0051446 positive regulation of meiotic cell cycle 1/1036 24/18670 0.7461 0.8885 0.7845 CDC25B 1 GO:0060343 trabecula formation 1/1036 24/18670 0.7461 0.8885 0.7845 TGFBR3 1 GO:0060396 growth hormone receptor signaling pathway 1/1036 24/18670 0.7461 0.8885 0.7845 PIK3R1 1 GO:0071218 cellular response to misfolded protein 1/1036 24/18670 0.7461 0.8885 0.7845 DERL1 1 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 1/1036 24/18670 0.7461 0.8885 0.7845 ATP1B1 1 GO:0090103 cochlea morphogenesis 1/1036 24/18670 0.7461 0.8885 0.7845 FZD2 1 GO:0099590 neurotransmitter receptor internalization 1/1036 24/18670 0.7461 0.8885 0.7845 AP2B1 1 GO:1901071 glucosamine-containing compound metabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 GNE 1 GO:1903020 positive regulation of glycoprotein metabolic process 1/1036 24/18670 0.7461 0.8885 0.7845 IL15 1 GO:1903421 regulation of synaptic vesicle recycling 1/1036 24/18670 0.7461 0.8885 0.7845 DNM1L 1 GO:1905564 positive regulation of vascular endothelial cell proliferation 1/1036 24/18670 0.7461 0.8885 0.7845 ITGA4 1 GO:2000209 regulation of anoikis 1/1036 24/18670 0.7461 0.8885 0.7845 PIK3CA 1 GO:2001026 regulation of endothelial cell chemotaxis 1/1036 24/18670 0.7461 0.8885 0.7845 FGF18 1 GO:0003158 endothelium development 6/1036 132/18670 0.7475 0.8896 0.7856 IL1B/PPP1R16B/ACVR1/TNF/CXCR4/HEG1 6 GO:0045995 regulation of embryonic development 6/1036 132/18670 0.7475 0.8896 0.7856 PRKACB/POGLUT1/SULF1/MBP/CLASP1/FZD2 6 GO:0014909 smooth muscle cell migration 4/1036 91/18670 0.7506 0.8931 0.7886 CCL5/LRP1/PARVA/HDAC4 4 GO:0032535 regulation of cellular component size 18/1036 370/18670 0.7512 0.8931 0.7886 NCK1/RASA1/ADD3/ARHGAP4/SLC12A5/WAS/CLNS1A/MAP2/LRP1/SEMA4G/SEMA3G/CCL11/DBN1/DSCAM/HAX1/NTN1/SH3BP1/ADNP 18 GO:0014902 myotube differentiation 5/1036 112/18670 0.7513 0.8931 0.7886 EHD2/XBP1/KCNH1/HDAC4/CD9 5 GO:0042303 molting cycle 5/1036 112/18670 0.7513 0.8931 0.7886 SOS1/TNF/LRIG1/TGM3/SOX21 5 GO:0042633 hair cycle 5/1036 112/18670 0.7513 0.8931 0.7886 SOS1/TNF/LRIG1/TGM3/SOX21 5 GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 5/1036 112/18670 0.7513 0.8931 0.7886 CCL5/PTX3/RAB9A/ELANE/CTSG 5 GO:0001756 somitogenesis 3/1036 70/18670 0.7533 0.8934 0.7889 POGLUT1/XRCC2/TMED2 3 GO:2001259 positive regulation of cation channel activity 3/1036 70/18670 0.7533 0.8934 0.7889 IFNG/NTSR1/EHD3 3 GO:0006111 regulation of gluconeogenesis 2/1036 48/18670 0.7538 0.8934 0.7889 CRY1/CLK2 2 GO:0007140 male meiotic nuclear division 2/1036 48/18670 0.7538 0.8934 0.7889 MYBL1/UBB 2 GO:0007528 neuromuscular junction development 2/1036 48/18670 0.7538 0.8934 0.7889 FNTA/CACNB4 2 GO:0008542 visual learning 2/1036 48/18670 0.7538 0.8934 0.7889 DDHD2/HRH2 2 GO:0010107 potassium ion import 2/1036 48/18670 0.7538 0.8934 0.7889 SLC12A5/ATP1B1 2 GO:0032648 regulation of interferon-beta production 2/1036 48/18670 0.7538 0.8934 0.7889 TLR3/POLR3C 2 GO:0043268 positive regulation of potassium ion transport 2/1036 48/18670 0.7538 0.8934 0.7889 ATP1B1/KCNQ1 2 GO:0046850 regulation of bone remodeling 2/1036 48/18670 0.7538 0.8934 0.7889 CD38/IL6 2 GO:0051150 regulation of smooth muscle cell differentiation 2/1036 48/18670 0.7538 0.8934 0.7889 ANKRD17/SMARCD3 2 GO:0051653 spindle localization 2/1036 48/18670 0.7538 0.8934 0.7889 NDC80/CLASP1 2 GO:0061647 histone H3-K9 modification 2/1036 48/18670 0.7538 0.8934 0.7889 SPHK2/ATRX 2 GO:1902903 regulation of supramolecular fiber organization 17/1036 352/18670 0.7568 0.8945 0.7899 NCK1/RASA1/ADD3/WAS/CKAP2/MAP2/RANGRF/CCL11/PTGER4/CLASP1/DBN1/DYRK1A/HAX1/COLGALT1/SH3BP1/TERF1/PIK3R1 17 GO:0001562 response to protozoan 1/1036 25/18670 0.7603 0.8945 0.7899 IL12B 1 GO:0002068 glandular epithelial cell development 1/1036 25/18670 0.7603 0.8945 0.7899 RARA 1 GO:0006688 glycosphingolipid biosynthetic process 1/1036 25/18670 0.7603 0.8945 0.7899 ST3GAL5 1 GO:0006851 mitochondrial calcium ion transmembrane transport 1/1036 25/18670 0.7603 0.8945 0.7899 PHB2 1 GO:0008211 glucocorticoid metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 HSD11B2 1 GO:0008334 histone mRNA metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 SNRPF 1 GO:0009404 toxin metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 CBS 1 GO:0030813 positive regulation of nucleotide catabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 IFNG 1 GO:0031069 hair follicle morphogenesis 1/1036 25/18670 0.7603 0.8945 0.7899 TGM3 1 GO:0032104 regulation of response to extracellular stimulus 1/1036 25/18670 0.7603 0.8945 0.7899 TRIM24 1 GO:0032107 regulation of response to nutrient levels 1/1036 25/18670 0.7603 0.8945 0.7899 TRIM24 1 GO:0032461 positive regulation of protein oligomerization 1/1036 25/18670 0.7603 0.8945 0.7899 PMAIP1 1 GO:0034035 purine ribonucleoside bisphosphate metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 TPST1 1 GO:0035235 ionotropic glutamate receptor signaling pathway 1/1036 25/18670 0.7603 0.8945 0.7899 GRIN2D 1 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 ACSL3 1 GO:0043951 negative regulation of cAMP-mediated signaling 1/1036 25/18670 0.7603 0.8945 0.7899 CRTC3 1 GO:0044247 cellular polysaccharide catabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 PHKG1 1 GO:0045662 negative regulation of myoblast differentiation 1/1036 25/18670 0.7603 0.8945 0.7899 TNF 1 GO:0045956 positive regulation of calcium ion-dependent exocytosis 1/1036 25/18670 0.7603 0.8945 0.7899 DNM1L 1 GO:0046755 viral budding 1/1036 25/18670 0.7603 0.8945 0.7899 VPS37B 1 GO:0046856 phosphatidylinositol dephosphorylation 1/1036 25/18670 0.7603 0.8945 0.7899 CHRM5 1 GO:0048103 somatic stem cell division 1/1036 25/18670 0.7603 0.8945 0.7899 LBH 1 GO:0050927 positive regulation of positive chemotaxis 1/1036 25/18670 0.7603 0.8945 0.7899 ARTN 1 GO:0051156 glucose 6-phosphate metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 DERA 1 GO:0051197 positive regulation of coenzyme metabolic process 1/1036 25/18670 0.7603 0.8945 0.7899 IFNG 1 GO:0060561 apoptotic process involved in morphogenesis 1/1036 25/18670 0.7603 0.8945 0.7899 SPI1 1 GO:0060571 morphogenesis of an epithelial fold 1/1036 25/18670 0.7603 0.8945 0.7899 SULF1 1 GO:0071378 cellular response to growth hormone stimulus 1/1036 25/18670 0.7603 0.8945 0.7899 PIK3R1 1 GO:1903306 negative regulation of regulated secretory pathway 1/1036 25/18670 0.7603 0.8945 0.7899 BCR 1 GO:1904385 cellular response to angiotensin 1/1036 25/18670 0.7603 0.8945 0.7899 NFKB1 1 GO:1904861 excitatory synapse assembly 1/1036 25/18670 0.7603 0.8945 0.7899 PLXNB2 1 GO:1905809 negative regulation of synapse organization 1/1036 25/18670 0.7603 0.8945 0.7899 FYN 1 GO:0008347 glial cell migration 2/1036 49/18670 0.7639 0.8978 0.7928 LRP1/GPR183 2 GO:0010712 regulation of collagen metabolic process 2/1036 49/18670 0.7639 0.8978 0.7928 IL6/CBX8 2 GO:0034260 negative regulation of GTPase activity 2/1036 49/18670 0.7639 0.8978 0.7928 RHOH/TMED2 2 GO:0048546 digestive tract morphogenesis 2/1036 49/18670 0.7639 0.8978 0.7928 DACT1/SIX2 2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation 2/1036 49/18670 0.7639 0.8978 0.7928 LDLRAP1/TNF 2 GO:0007127 meiosis I 5/1036 114/18670 0.7649 0.8988 0.7937 MYBL1/CDC25B/FBXO5/UBB/TERF1 5 GO:0000045 autophagosome assembly 4/1036 93/18670 0.7656 0.8994 0.7942 ATG14/SCFD1/ATG5/FEZ1 4 GO:0090596 sensory organ morphogenesis 12/1036 256/18670 0.7661 0.8997 0.7945 INSIG1/LRIG1/PRKRA/MAPK3/HMGN1/DSCAM/SOD1/NTN1/TRPM1/SIX2/FZD2/BCR 12 GO:0007498 mesoderm development 6/1036 135/18670 0.7664 0.8997 0.7945 POGLUT1/ACVR1/TSPY1/CITED2/ITGB4/SIX2 6 GO:0030010 establishment of cell polarity 6/1036 135/18670 0.7664 0.8997 0.7945 MAP2/NDC80/STK11/CLASP1/SH3BP1/FEZ1 6 GO:0034767 positive regulation of ion transmembrane transport 7/1036 156/18670 0.7689 0.9009 0.7956 CXCL11/ABCB1/IFNG/NTSR1/ATP1B1/EHD3/KCNQ1 7 GO:0032272 negative regulation of protein polymerization 3/1036 72/18670 0.7701 0.9009 0.7956 ADD3/MAP2/DYRK1A 3 GO:0035019 somatic stem cell population maintenance 3/1036 72/18670 0.7701 0.9009 0.7956 LBH/SPI1/SIX2 3 GO:0032612 interleukin-1 production 5/1036 115/18670 0.7715 0.9009 0.7956 IFNG/IL1B/MALT1/ANXA1/TLR6 5 GO:0007416 synapse assembly 8/1036 177/18670 0.7722 0.9009 0.7956 AMIGO2/PLXNB2/PCDHB13/GABRB2/DSCAM/PCDHB6/NTN1/ADNP 8 GO:0048469 cell maturation 8/1036 177/18670 0.7722 0.9009 0.7956 POU2F2/CDC25B/DLD/XBP1/FBXO5/GHRHR/IL15/ZBTB7A 8 GO:0045814 negative regulation of gene expression, epigenetic 6/1036 136/18670 0.7724 0.9009 0.7956 HAT1/RBBP4/HIRA/RBBP7/SPI1/SMARCA5 6 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 1/1036 26/18670 0.7736 0.9009 0.7956 CTSG 1 GO:0006309 apoptotic DNA fragmentation 1/1036 26/18670 0.7736 0.9009 0.7956 IL6 1 GO:0006817 phosphate ion transport 1/1036 26/18670 0.7736 0.9009 0.7956 SLC20A1 1 GO:0010996 response to auditory stimulus 1/1036 26/18670 0.7736 0.9009 0.7956 SLC1A3 1 GO:0015985 energy coupled proton transport, down electrochemical gradient 1/1036 26/18670 0.7736 0.9009 0.7956 CYC1 1 GO:0015986 ATP synthesis coupled proton transport 1/1036 26/18670 0.7736 0.9009 0.7956 CYC1 1 GO:0022011 myelination in peripheral nervous system 1/1036 26/18670 0.7736 0.9009 0.7956 SOD1 1 GO:0032292 peripheral nervous system axon ensheathment 1/1036 26/18670 0.7736 0.9009 0.7956 SOD1 1 GO:0032967 positive regulation of collagen biosynthetic process 1/1036 26/18670 0.7736 0.9009 0.7956 CBX8 1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling 1/1036 26/18670 0.7736 0.9009 0.7956 PLA2G3 1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 1/1036 26/18670 0.7736 0.9009 0.7956 GHRHR 1 GO:0050926 regulation of positive chemotaxis 1/1036 26/18670 0.7736 0.9009 0.7956 ARTN 1 GO:0051125 regulation of actin nucleation 1/1036 26/18670 0.7736 0.9009 0.7956 WAS 1 GO:0055083 monovalent inorganic anion homeostasis 1/1036 26/18670 0.7736 0.9009 0.7956 SLC12A5 1 GO:0060037 pharyngeal system development 1/1036 26/18670 0.7736 0.9009 0.7956 ACVR1 1 GO:0060544 regulation of necroptotic process 1/1036 26/18670 0.7736 0.9009 0.7956 BIRC3 1 GO:0060669 embryonic placenta morphogenesis 1/1036 26/18670 0.7736 0.9009 0.7956 SPINT1 1 GO:0060706 cell differentiation involved in embryonic placenta development 1/1036 26/18670 0.7736 0.9009 0.7956 LIF 1 GO:0060740 prostate gland epithelium morphogenesis 1/1036 26/18670 0.7736 0.9009 0.7956 SULF1 1 GO:0060914 heart formation 1/1036 26/18670 0.7736 0.9009 0.7956 SMARCD3 1 GO:0071711 basement membrane organization 1/1036 26/18670 0.7736 0.9009 0.7956 CLASP1 1 GO:0080111 DNA demethylation 1/1036 26/18670 0.7736 0.9009 0.7956 APOBEC3G 1 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 1/1036 26/18670 0.7736 0.9009 0.7956 ATP1B1 1 GO:1903959 regulation of anion transmembrane transport 1/1036 26/18670 0.7736 0.9009 0.7956 ABCB1 1 GO:1904754 positive regulation of vascular associated smooth muscle cell migration 1/1036 26/18670 0.7736 0.9009 0.7956 LRP1 1 GO:0032608 interferon-beta production 2/1036 50/18670 0.7737 0.9009 0.7956 TLR3/POLR3C 2 GO:0060976 coronary vasculature development 2/1036 50/18670 0.7737 0.9009 0.7956 TGFBR3/AP2B1 2 GO:0086009 membrane repolarization 2/1036 50/18670 0.7737 0.9009 0.7956 ATP1B1/KCNQ1 2 GO:0097035 regulation of membrane lipid distribution 2/1036 50/18670 0.7737 0.9009 0.7956 ABCB1/ATP8A1 2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 2/1036 50/18670 0.7737 0.9009 0.7956 ANKRD17/ANXA1 2 GO:0001764 neuron migration 7/1036 157/18670 0.7746 0.9018 0.7963 AUTS2/FYN/CXCR4/PLXNB2/PCM1/TLX3/NTN1 7 GO:0006814 sodium ion transport 10/1036 218/18670 0.775 0.9022 0.7966 SLC38A1/SCN10A/TRPM2/SLC8A2/GPD1L/ATP1B1/SLC10A2/RANGRF/SLC38A2/SLC20A1 10 GO:0031099 regeneration 9/1036 198/18670 0.7759 0.9029 0.7973 PCNA/TGFBR2/MTR/TGFBR3/ANXA1/CSNK2A2/LRP1/CD9/ADAM15 9 GO:0021987 cerebral cortex development 5/1036 116/18670 0.778 0.9052 0.7993 TRA2B/CSNK2A2/LRP1/SLC38A2/TMEM14B 5 GO:0006801 superoxide metabolic process 3/1036 73/18670 0.7781 0.9052 0.7993 SOD3/TNF/SOD1 3 GO:0009952 anterior/posterior pattern specification 10/1036 219/18670 0.7798 0.9068 0.8007 POGLUT1/BTG2/HOXA6/MLLT3/ZBTB16/BPTF/PGAP1/XRCC2/SIX2/TMED2 10 GO:0110020 regulation of actomyosin structure organization 4/1036 95/18670 0.7799 0.9068 0.8007 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0050866 negative regulation of cell activation 9/1036 199/18670 0.7808 0.9076 0.8014 ABAT/GCLC/PTPN22/ANXA1/TBX21/CST7/CD9/PGLYRP4/BCR 9 GO:0008064 regulation of actin polymerization or depolymerization 8/1036 179/18670 0.7826 0.9076 0.8014 NCK1/RASA1/ADD3/WAS/CCL11/DBN1/HAX1/SH3BP1 8 GO:0048736 appendage development 8/1036 179/18670 0.7826 0.9076 0.8014 GNAS/ITGA6/RECK/BMPR1B/RARA/ZBTB16/ITGB4/ATRX 8 GO:0060173 limb development 8/1036 179/18670 0.7826 0.9076 0.8014 GNAS/ITGA6/RECK/BMPR1B/RARA/ZBTB16/ITGB4/ATRX 8 GO:0021545 cranial nerve development 2/1036 51/18670 0.783 0.9076 0.8014 ERBB3/SLC1A3 2 GO:0030834 regulation of actin filament depolymerization 2/1036 51/18670 0.783 0.9076 0.8014 ADD3/SH3BP1 2 GO:0031103 axon regeneration 2/1036 51/18670 0.783 0.9076 0.8014 MTR/LRP1 2 GO:0045668 negative regulation of osteoblast differentiation 2/1036 51/18670 0.783 0.9076 0.8014 TNF/HDAC4 2 GO:0048146 positive regulation of fibroblast proliferation 2/1036 51/18670 0.783 0.9076 0.8014 MYC/NDUFS4 2 GO:0050999 regulation of nitric-oxide synthase activity 2/1036 51/18670 0.783 0.9076 0.8014 IL1B/TNF 2 GO:0051452 intracellular pH reduction 2/1036 51/18670 0.783 0.9076 0.8014 CA7/SLAMF8 2 GO:0090102 cochlea development 2/1036 51/18670 0.783 0.9076 0.8014 GABRB2/FZD2 2 GO:0097366 response to bronchodilator 2/1036 51/18670 0.783 0.9076 0.8014 MTR/SOD1 2 GO:0002673 regulation of acute inflammatory response 7/1036 159/18670 0.7855 0.9076 0.8014 IL6/IL1B/C1QBP/TNF/F12/C8B/CD5L 7 GO:0072078 nephron tubule morphogenesis 3/1036 74/18670 0.7859 0.9076 0.8014 MYC/MAGED1/SIX2 3 GO:0099601 regulation of neurotransmitter receptor activity 3/1036 74/18670 0.7859 0.9076 0.8014 IFNG/CAPN1/FNTA 3 GO:0000272 polysaccharide catabolic process 1/1036 27/18670 0.7862 0.9076 0.8014 PHKG1 1 GO:0006730 one-carbon metabolic process 1/1036 27/18670 0.7862 0.9076 0.8014 AHCY 1 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1/1036 27/18670 0.7862 0.9076 0.8014 CBLB 1 GO:0010714 positive regulation of collagen metabolic process 1/1036 27/18670 0.7862 0.9076 0.8014 CBX8 1 GO:0015721 bile acid and bile salt transport 1/1036 27/18670 0.7862 0.9076 0.8014 SLC10A2 1 GO:0022616 DNA strand elongation 1/1036 27/18670 0.7862 0.9076 0.8014 PCNA 1 GO:0035902 response to immobilization stress 1/1036 27/18670 0.7862 0.9076 0.8014 BRD1 1 GO:0036151 phosphatidylcholine acyl-chain remodeling 1/1036 27/18670 0.7862 0.9076 0.8014 PLA2G3 1 GO:0043921 modulation by host of viral transcription 1/1036 27/18670 0.7862 0.9076 0.8014 CCL5 1 GO:0045932 negative regulation of muscle contraction 1/1036 27/18670 0.7862 0.9076 0.8014 SOD1 1 GO:0048668 collateral sprouting 1/1036 27/18670 0.7862 0.9076 0.8014 LRP1 1 GO:0052472 modulation by host of symbiont transcription 1/1036 27/18670 0.7862 0.9076 0.8014 CCL5 1 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 1/1036 27/18670 0.7862 0.9076 0.8014 EHD2 1 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 1/1036 27/18670 0.7862 0.9076 0.8014 KCNQ1 1 GO:0080154 regulation of fertilization 1/1036 27/18670 0.7862 0.9076 0.8014 GLRA1 1 GO:0090169 regulation of spindle assembly 1/1036 27/18670 0.7862 0.9076 0.8014 RNF4 1 GO:1901623 regulation of lymphocyte chemotaxis 1/1036 27/18670 0.7862 0.9076 0.8014 CCL5 1 GO:0098876 vesicle-mediated transport to the plasma membrane 4/1036 96/18670 0.7867 0.9079 0.8017 OPTN/ANXA13/C16orf70/ACSL3 4 GO:1905037 autophagosome organization 4/1036 96/18670 0.7867 0.9079 0.8017 ATG14/SCFD1/ATG5/FEZ1 4 GO:0030832 regulation of actin filament length 8/1036 180/18670 0.7877 0.9088 0.8025 NCK1/RASA1/ADD3/WAS/CCL11/DBN1/HAX1/SH3BP1 8 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 10/1036 221/18670 0.789 0.9101 0.8037 CXCL11/CCR3/CHRM5/GNAS/PRKACB/RGS1/CHGA/CHRM2/PTGER4/GHRHR 10 GO:0007586 digestion 6/1036 139/18670 0.7899 0.9106 0.8041 CHRM5/MUC2/HRH2/CCKBR/KCNQ1/NMU 6 GO:0031333 negative regulation of protein complex assembly 6/1036 139/18670 0.7899 0.9106 0.8041 DACT1/INSIG1/ADD3/MAP2/PTGER4/DYRK1A 6 GO:0035304 regulation of protein dephosphorylation 6/1036 139/18670 0.7899 0.9106 0.8041 PPP1R17/PPP1R16B/PPP2R5C/PPP1R8/TNF/IGBP1 6 GO:1903305 regulation of regulated secretory pathway 7/1036 160/18670 0.7908 0.9111 0.8045 ATP2A2/P2RX1/MICAL1/DNM1L/SPHK2/CHRM2/BCR 7 GO:0003179 heart valve morphogenesis 2/1036 52/18670 0.7921 0.9111 0.8045 TGFBR2/ACVR1 2 GO:0015872 dopamine transport 2/1036 52/18670 0.7921 0.9111 0.8045 ABAT/CHRM5 2 GO:0032731 positive regulation of interleukin-1 beta production 2/1036 52/18670 0.7921 0.9111 0.8045 IFNG/MALT1 2 GO:0035176 social behavior 2/1036 52/18670 0.7921 0.9111 0.8045 GNB1L/PCM1 2 GO:0051703 intraspecies interaction between organisms 2/1036 52/18670 0.7921 0.9111 0.8045 GNB1L/PCM1 2 GO:1900024 regulation of substrate adhesion-dependent cell spreading 2/1036 52/18670 0.7921 0.9111 0.8045 C1QBP/ARHGEF7 2 GO:2000179 positive regulation of neural precursor cell proliferation 2/1036 52/18670 0.7921 0.9111 0.8045 NAP1L1/SMARCD3 2 GO:2000772 regulation of cellular senescence 2/1036 52/18670 0.7921 0.9111 0.8045 EEF1E1/FBXO5 2 GO:0032231 regulation of actin filament bundle assembly 4/1036 97/18670 0.7934 0.9111 0.8045 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0044773 mitotic DNA damage checkpoint 4/1036 97/18670 0.7934 0.9111 0.8045 PCNA/BTG2/MSH2/DONSON 4 GO:0120162 positive regulation of cold-induced thermogenesis 4/1036 97/18670 0.7934 0.9111 0.8045 GNAS/CXCR4/FH/ZNF516 4 GO:0001707 mesoderm formation 3/1036 75/18670 0.7935 0.9111 0.8045 ACVR1/ITGB4/SIX2 3 GO:0001960 negative regulation of cytokine-mediated signaling pathway 3/1036 75/18670 0.7935 0.9111 0.8045 CCL5/IL6/PIAS4 3 GO:0007422 peripheral nervous system development 3/1036 75/18670 0.7935 0.9111 0.8045 ERBB3/ARTN/SOD1 3 GO:0021536 diencephalon development 3/1036 75/18670 0.7935 0.9111 0.8045 LHX3/GHRHR/UBB 3 GO:0016079 synaptic vesicle exocytosis 5/1036 119/18670 0.7965 0.9111 0.8045 ATP2A2/P2RX1/SV2A/DNM1L/CHRM2 5 GO:0061982 meiosis I cell cycle process 5/1036 119/18670 0.7965 0.9111 0.8045 MYBL1/CDC25B/FBXO5/UBB/TERF1 5 GO:0032956 regulation of actin cytoskeleton organization 16/1036 343/18670 0.7972 0.9111 0.8045 RHOH/NCK1/ARHGAP17/RASA1/ADD3/TRPM2/WAS/CD2AP/LRP1/CCL11/PTGER4/CLASP1/DBN1/HAX1/SH3BP1/PIK3R1 16 GO:0030041 actin filament polymerization 8/1036 182/18670 0.7976 0.9111 0.8045 NCK1/RASA1/ADD3/WAS/PSTPIP1/CCL11/DBN1/HAX1 8 GO:1901342 regulation of vasculature development 20/1036 422/18670 0.7979 0.9111 0.8045 IL1A/IL6/PGK1/CCR3/TGFBR2/IL1B/PPP1R16B/RRAS/HSPB6/RECK/CXCR4/ANXA1/EMP2/TLR3/XBP1/SULF1/PIK3C2A/CCL11/STAB1/FGF18 20 GO:0001702 gastrulation with mouth forming second 1/1036 28/18670 0.798 0.9111 0.8045 ACVR1 1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 1/1036 28/18670 0.798 0.9111 0.8045 DERL1 1 GO:0006760 folic acid-containing compound metabolic process 1/1036 28/18670 0.798 0.9111 0.8045 SLC25A32 1 GO:0009065 glutamine family amino acid catabolic process 1/1036 28/18670 0.798 0.9111 0.8045 GAD2 1 GO:0018146 keratan sulfate biosynthetic process 1/1036 28/18670 0.798 0.9111 0.8045 B3GNT2 1 GO:0021846 cell proliferation in forebrain 1/1036 28/18670 0.798 0.9111 0.8045 PCM1 1 GO:0032647 regulation of interferon-alpha production 1/1036 28/18670 0.798 0.9111 0.8045 TLR3 1 GO:0033598 mammary gland epithelial cell proliferation 1/1036 28/18670 0.798 0.9111 0.8045 PHB2 1 GO:0034368 protein-lipid complex remodeling 1/1036 28/18670 0.798 0.9111 0.8045 CETP 1 GO:0034369 plasma lipoprotein particle remodeling 1/1036 28/18670 0.798 0.9111 0.8045 CETP 1 GO:0035456 response to interferon-beta 1/1036 28/18670 0.798 0.9111 0.8045 TLR3 1 GO:0036296 response to increased oxygen levels 1/1036 28/18670 0.798 0.9111 0.8045 CAT 1 GO:0042634 regulation of hair cycle 1/1036 28/18670 0.798 0.9111 0.8045 TNF 1 GO:0042730 fibrinolysis 1/1036 28/18670 0.798 0.9111 0.8045 F12 1 GO:0045686 negative regulation of glial cell differentiation 1/1036 28/18670 0.798 0.9111 0.8045 DAAM2 1 GO:0045761 regulation of adenylate cyclase activity 1/1036 28/18670 0.798 0.9111 0.8045 TIMP2 1 GO:0048679 regulation of axon regeneration 1/1036 28/18670 0.798 0.9111 0.8045 LRP1 1 GO:0052312 modulation of transcription in other organism involved in symbiotic interaction 1/1036 28/18670 0.798 0.9111 0.8045 CCL5 1 GO:0060122 inner ear receptor cell stereocilium organization 1/1036 28/18670 0.798 0.9111 0.8045 SOD1 1 GO:0060512 prostate gland morphogenesis 1/1036 28/18670 0.798 0.9111 0.8045 SULF1 1 GO:0071168 protein localization to chromatin 1/1036 28/18670 0.798 0.9111 0.8045 MSH2 1 GO:0090344 negative regulation of cell aging 1/1036 28/18670 0.798 0.9111 0.8045 FBXO5 1 GO:0090383 phagosome acidification 1/1036 28/18670 0.798 0.9111 0.8045 SLAMF8 1 GO:1990776 response to angiotensin 1/1036 28/18670 0.798 0.9111 0.8045 NFKB1 1 GO:0006885 regulation of pH 4/1036 98/18670 0.8 0.9123 0.8056 CCKBR/MAPK3/CA7/SLAMF8 4 GO:0030038 contractile actin filament bundle assembly 4/1036 98/18670 0.8 0.9123 0.8056 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0043149 stress fiber assembly 4/1036 98/18670 0.8 0.9123 0.8056 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0006376 mRNA splice site selection 2/1036 53/18670 0.8008 0.9123 0.8056 SRSF10/SETX 2 GO:0007632 visual behavior 2/1036 53/18670 0.8008 0.9123 0.8056 DDHD2/HRH2 2 GO:0021879 forebrain neuron differentiation 2/1036 53/18670 0.8008 0.9123 0.8056 BCL11B/UBB 2 GO:0070228 regulation of lymphocyte apoptotic process 2/1036 53/18670 0.8008 0.9123 0.8056 CCL5/PRKCQ 2 GO:0071320 cellular response to cAMP 2/1036 53/18670 0.8008 0.9123 0.8056 FDX1/KCNQ1 2 GO:1903307 positive regulation of regulated secretory pathway 2/1036 53/18670 0.8008 0.9123 0.8056 DNM1L/SPHK2 2 GO:0001937 negative regulation of endothelial cell proliferation 3/1036 76/18670 0.8009 0.9123 0.8056 TNF/SULF1/AIMP1 3 GO:0030833 regulation of actin filament polymerization 7/1036 162/18670 0.8012 0.9125 0.8058 NCK1/RASA1/ADD3/WAS/CCL11/DBN1/HAX1 7 GO:0006721 terpenoid metabolic process 5/1036 120/18670 0.8024 0.9135 0.8066 LRP1/CYP2C9/AKR1B1/AKR1C3/RDH16 5 GO:0072089 stem cell proliferation 5/1036 120/18670 0.8024 0.9135 0.8066 ABCB1/PLXNB2/ARTN/SMARCD3/SIX2 5 GO:0097479 synaptic vesicle localization 7/1036 163/18670 0.8062 0.9149 0.8079 ATP2A2/TMEM230/P2RX1/SV2A/MAP2/DNM1L/CHRM2 7 GO:0099173 postsynapse organization 7/1036 163/18670 0.8062 0.9149 0.8079 FYN/FNTA/CAPRIN2/DNM1L/ACTN1/DBN1/CAPRIN1 7 GO:0034332 adherens junction organization 6/1036 142/18670 0.8064 0.9149 0.8079 LRP1/ARHGEF7/ACTN1/KIFC3/CLASP1/BCR 6 GO:1902904 negative regulation of supramolecular fiber organization 6/1036 142/18670 0.8064 0.9149 0.8079 ADD3/WAS/CKAP2/MAP2/CLASP1/DYRK1A 6 GO:0008544 epidermis development 22/1036 464/18670 0.8067 0.9149 0.8079 SOS1/PRKCH/CAPN1/PLOD1/ATP2A2/ZFP36/KRT9/TNF/WAS/ANXA1/BCL11B/NCOA3/TGM3/SOX21/AGPAT2/AKR1C3/SOD1/KLK13/KRT76/SATB1/BCR/EDA2R 22 GO:0048332 mesoderm morphogenesis 3/1036 77/18670 0.808 0.9149 0.8079 ACVR1/ITGB4/SIX2 3 GO:0048678 response to axon injury 3/1036 77/18670 0.808 0.9149 0.8079 MTR/LRP1/SOD1 3 GO:0051937 catecholamine transport 3/1036 77/18670 0.808 0.9149 0.8079 ABAT/CHRM5/CHGA 3 GO:2000779 regulation of double-strand break repair 3/1036 77/18670 0.808 0.9149 0.8079 PARP1/WAS/POLQ 3 GO:0006584 catecholamine metabolic process 2/1036 54/18670 0.8092 0.9149 0.8079 ABAT/AKR1B1 2 GO:0009712 catechol-containing compound metabolic process 2/1036 54/18670 0.8092 0.9149 0.8079 ABAT/AKR1B1 2 GO:0043392 negative regulation of DNA binding 2/1036 54/18670 0.8092 0.9149 0.8079 GZMA/TNKS 2 GO:0051290 protein heterotetramerization 2/1036 54/18670 0.8092 0.9149 0.8079 PDSS1/NUDT21 2 GO:0070206 protein trimerization 2/1036 54/18670 0.8092 0.9149 0.8079 CD247/OTC 2 GO:0000132 establishment of mitotic spindle orientation 1/1036 29/18670 0.8093 0.9149 0.8079 NDC80 1 GO:0000395 mRNA 5'-splice site recognition 1/1036 29/18670 0.8093 0.9149 0.8079 SRSF10 1 GO:0010669 epithelial structure maintenance 1/1036 29/18670 0.8093 0.9149 0.8079 MUC2 1 GO:0014044 Schwann cell development 1/1036 29/18670 0.8093 0.9149 0.8079 SOD1 1 GO:0018200 peptidyl-glutamic acid modification 1/1036 29/18670 0.8093 0.9149 0.8079 PARP1 1 GO:0021884 forebrain neuron development 1/1036 29/18670 0.8093 0.9149 0.8079 UBB 1 GO:0032372 negative regulation of sterol transport 1/1036 29/18670 0.8093 0.9149 0.8079 NFKB1 1 GO:0032375 negative regulation of cholesterol transport 1/1036 29/18670 0.8093 0.9149 0.8079 NFKB1 1 GO:0042219 cellular modified amino acid catabolic process 1/1036 29/18670 0.8093 0.9149 0.8079 AHCY 1 GO:0044550 secondary metabolite biosynthetic process 1/1036 29/18670 0.8093 0.9149 0.8079 CBS 1 GO:0044788 modulation by host of viral process 1/1036 29/18670 0.8093 0.9149 0.8079 PTX3 1 GO:0045822 negative regulation of heart contraction 1/1036 29/18670 0.8093 0.9149 0.8079 ATP2A2 1 GO:0048240 sperm capacitation 1/1036 29/18670 0.8093 0.9149 0.8079 DLD 1 GO:0048730 epidermis morphogenesis 1/1036 29/18670 0.8093 0.9149 0.8079 TGM3 1 GO:0060142 regulation of syncytium formation by plasma membrane fusion 1/1036 29/18670 0.8093 0.9149 0.8079 EHD2 1 GO:0060441 epithelial tube branching involved in lung morphogenesis 1/1036 29/18670 0.8093 0.9149 0.8079 TNF 1 GO:0061099 negative regulation of protein tyrosine kinase activity 1/1036 29/18670 0.8093 0.9149 0.8079 CBLB 1 GO:0070723 response to cholesterol 1/1036 29/18670 0.8093 0.9149 0.8079 TGFBR2 1 GO:0071280 cellular response to copper ion 1/1036 29/18670 0.8093 0.9149 0.8079 DAXX 1 GO:0048638 regulation of developmental growth 16/1036 347/18670 0.8113 0.917 0.8097 TGFBR2/ARHGAP4/CPNE6/TGFBR3/CXCR4/MAP2/LRP1/SEMA4G/PIK3CA/SEMA3G/DBN1/GHRHR/DSCAM/SOD1/NTN1/ADNP 16 GO:0034446 substrate adhesion-dependent cell spreading 4/1036 100/18670 0.8125 0.918 0.8106 C1QBP/ITGA4/ARHGEF7/PARVA 4 GO:0035282 segmentation 4/1036 100/18670 0.8125 0.918 0.8106 POGLUT1/MLLT3/XRCC2/TMED2 4 GO:0008589 regulation of smoothened signaling pathway 3/1036 78/18670 0.8149 0.9195 0.812 RORA/PRKACB/CD3E 3 GO:0010827 regulation of glucose transmembrane transport 3/1036 78/18670 0.8149 0.9195 0.812 IL1B/TNF/PIK3R1 3 GO:0021954 central nervous system neuron development 3/1036 78/18670 0.8149 0.9195 0.812 BTG2/MAP2/UBB 3 GO:0030433 ubiquitin-dependent ERAD pathway 3/1036 78/18670 0.8149 0.9195 0.812 DERL1/EDEM1/UBE2J1 3 GO:0031016 pancreas development 3/1036 78/18670 0.8149 0.9195 0.812 IL6/ANXA1/XBP1 3 GO:0061333 renal tubule morphogenesis 3/1036 78/18670 0.8149 0.9195 0.812 MYC/MAGED1/SIX2 3 GO:0071695 anatomical structure maturation 7/1036 165/18670 0.816 0.9206 0.8129 CDC25B/RECK/ANKRD17/XBP1/LYL1/FBXO5/ZBTB7A 7 GO:1904064 positive regulation of cation transmembrane transport 6/1036 144/18670 0.8168 0.921 0.8133 CXCL11/IFNG/NTSR1/ATP1B1/EHD3/KCNQ1 6 GO:0002011 morphogenesis of an epithelial sheet 2/1036 55/18670 0.8173 0.921 0.8133 SOS1/CLASP1 2 GO:0042306 regulation of protein import into nucleus 2/1036 55/18670 0.8173 0.921 0.8133 IFNG/PIK3R1 2 GO:0043954 cellular component maintenance 2/1036 55/18670 0.8173 0.921 0.8133 FYN/KIFC3 2 GO:0070830 bicellular tight junction assembly 2/1036 55/18670 0.8173 0.921 0.8133 PRKCH/TNF 2 GO:0007631 feeding behavior 4/1036 101/18670 0.8186 0.9212 0.8135 UBE2Q1/FYN/TRH/NMU 4 GO:0032611 interleukin-1 beta production 4/1036 101/18670 0.8186 0.9212 0.8135 IFNG/IL1B/MALT1/TLR6 4 GO:1990542 mitochondrial transmembrane transport 4/1036 101/18670 0.8186 0.9212 0.8135 SLC25A32/CYC1/AGK/TOMM20 4 GO:0006836 neurotransmitter transport 12/1036 269/18670 0.8198 0.9212 0.8135 ABAT/ATP2A2/KMO/P2RX1/SLC38A1/NTSR1/SV2A/DNM1L/TRH/CHRM2/GAD2/SLC1A3 12 GO:0001782 B cell homeostasis 1/1036 30/18670 0.8199 0.9212 0.8135 SOS1 1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 1/1036 30/18670 0.8199 0.9212 0.8135 TGFBR2 1 GO:0032607 interferon-alpha production 1/1036 30/18670 0.8199 0.9212 0.8135 TLR3 1 GO:0036258 multivesicular body assembly 1/1036 30/18670 0.8199 0.9212 0.8135 VPS37B 1 GO:0042759 long-chain fatty acid biosynthetic process 1/1036 30/18670 0.8199 0.9212 0.8135 CYP2C9 1 GO:0043171 peptide catabolic process 1/1036 30/18670 0.8199 0.9212 0.8135 XPNPEP1 1 GO:0048147 negative regulation of fibroblast proliferation 1/1036 30/18670 0.8199 0.9212 0.8135 MYC 1 GO:0061037 negative regulation of cartilage development 1/1036 30/18670 0.8199 0.9212 0.8135 RARA 1 GO:0071480 cellular response to gamma radiation 1/1036 30/18670 0.8199 0.9212 0.8135 ATR 1 GO:1903205 regulation of hydrogen peroxide-induced cell death 1/1036 30/18670 0.8199 0.9212 0.8135 PDE8A 1 GO:0090288 negative regulation of cellular response to growth factor stimulus 7/1036 166/18670 0.8207 0.9219 0.8141 TGFBR2/HTRA1/TGFBR3/SULF1/UBA52/UBB/ZBTB7A 7 GO:0048167 regulation of synaptic plasticity 8/1036 187/18670 0.8208 0.9219 0.8141 CD38/HRH2/CALB2/RARA/SLC8A2/JPH3/DBN1/GRIN2D 8 GO:0043536 positive regulation of blood vessel endothelial cell migration 3/1036 79/18670 0.8216 0.9226 0.8147 ANXA1/PIK3C2A/FGF18 3 GO:0021549 cerebellum development 4/1036 102/18670 0.8245 0.9245 0.8164 ABAT/RORA/HERC1/CD3E 4 GO:0007043 cell-cell junction assembly 5/1036 124/18670 0.8246 0.9245 0.8164 FLCN/PRKCH/TNF/CD9/HEG1 5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 2/1036 56/18670 0.825 0.9245 0.8164 PCNA/BTG2 2 GO:0046148 pigment biosynthetic process 2/1036 56/18670 0.825 0.9245 0.8164 PRPS1/APRT 2 GO:0050879 multicellular organismal movement 2/1036 56/18670 0.825 0.9245 0.8164 SYNM/ATP2A2 2 GO:0050881 musculoskeletal movement 2/1036 56/18670 0.825 0.9245 0.8164 SYNM/ATP2A2 2 GO:0051568 histone H3-K4 methylation 2/1036 56/18670 0.825 0.9245 0.8164 AUTS2/CTR9 2 GO:0086002 cardiac muscle cell action potential involved in contraction 2/1036 56/18670 0.825 0.9245 0.8164 GPD1L/KCNQ1 2 GO:0120192 tight junction assembly 2/1036 56/18670 0.825 0.9245 0.8164 PRKCH/TNF 2 GO:1903202 negative regulation of oxidative stress-induced cell death 2/1036 56/18670 0.825 0.9245 0.8164 FYN/PDE8A 2 GO:1903046 meiotic cell cycle process 8/1036 188/18670 0.8252 0.9245 0.8164 MYBL1/CDC25B/LIF/FBXO5/UBB/ATRX/TERF1/SMC2 8 GO:0051701 interaction with host 9/1036 209/18670 0.8259 0.9251 0.8169 SLAMF1/PTX3/NPC1/CXCR4/EXOC7/VPS37B/FCN1/EFNB3/CBLL1 9 GO:0140029 exocytic process 3/1036 80/18670 0.8281 0.9253 0.8171 P2RX1/SCFD1/SV2A 3 GO:0021537 telencephalon development 11/1036 251/18670 0.8288 0.9253 0.8171 TRA2B/BTG2/CXCR4/CSNK2A2/LRP1/BCL11B/RARA/ATAT1/SLC38A2/TMEM14B/FEZ1 11 GO:0009410 response to xenobiotic stimulus 13/1036 292/18670 0.8295 0.9253 0.8171 CRYZ/PCNA/ABAT/RORA/PRKACB/GCLC/CXCR4/AKR7A2/PRKAR2B/CYP2C9/MARC1/SOD1/GSTA3 13 GO:0031929 TOR signaling 5/1036 125/18670 0.8298 0.9253 0.8171 FLCN/SESN1/PIK3CA/STK11/DYRK3 5 GO:0002082 regulation of oxidative phosphorylation 1/1036 31/18670 0.8299 0.9253 0.8171 PGK1 1 GO:0006506 GPI anchor biosynthetic process 1/1036 31/18670 0.8299 0.9253 0.8171 PGAP1 1 GO:0031572 G2 DNA damage checkpoint 1/1036 31/18670 0.8299 0.9253 0.8171 DONSON 1 GO:0035767 endothelial cell chemotaxis 1/1036 31/18670 0.8299 0.9253 0.8171 FGF18 1 GO:0036257 multivesicular body organization 1/1036 31/18670 0.8299 0.9253 0.8171 VPS37B 1 GO:0040018 positive regulation of multicellular organism growth 1/1036 31/18670 0.8299 0.9253 0.8171 GHRHR 1 GO:0043304 regulation of mast cell degranulation 1/1036 31/18670 0.8299 0.9253 0.8171 SPHK2 1 GO:0044319 wound healing, spreading of cells 1/1036 31/18670 0.8299 0.9253 0.8171 CLASP1 1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1/1036 31/18670 0.8299 0.9253 0.8171 PSMD10 1 GO:0046471 phosphatidylglycerol metabolic process 1/1036 31/18670 0.8299 0.9253 0.8171 PLA2G3 1 GO:0060292 long-term synaptic depression 1/1036 31/18670 0.8299 0.9253 0.8171 CD38 1 GO:0070306 lens fiber cell differentiation 1/1036 31/18670 0.8299 0.9253 0.8171 MAF 1 GO:0071539 protein localization to centrosome 1/1036 31/18670 0.8299 0.9253 0.8171 PCM1 1 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1/1036 31/18670 0.8299 0.9253 0.8171 CHGA 1 GO:0090505 epiboly involved in wound healing 1/1036 31/18670 0.8299 0.9253 0.8171 CLASP1 1 GO:0099625 ventricular cardiac muscle cell membrane repolarization 1/1036 31/18670 0.8299 0.9253 0.8171 KCNQ1 1 GO:1902186 regulation of viral release from host cell 1/1036 31/18670 0.8299 0.9253 0.8171 VPS37B 1 GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 1/1036 31/18670 0.8299 0.9253 0.8171 SPI1 1 GO:0001701 in utero embryonic development 17/1036 373/18670 0.8309 0.9261 0.8178 TGFBR2/BTF3/CTR9/FLCN/ACVR1/EMG1/MSH2/SPINT1/HOPX/LIF/DBN1/HEG1/BPTF/LPAR6/XRCC2/NCAPG2/TMED2 17 GO:0002066 columnar/cuboidal epithelial cell development 2/1036 57/18670 0.8325 0.9261 0.8178 RARA/SOD1 2 GO:0019320 hexose catabolic process 2/1036 57/18670 0.8325 0.9261 0.8178 PGK1/PFKP 2 GO:0043525 positive regulation of neuron apoptotic process 2/1036 57/18670 0.8325 0.9261 0.8178 TNF/HDAC4 2 GO:0045981 positive regulation of nucleotide metabolic process 2/1036 57/18670 0.8325 0.9261 0.8178 PGK1/IFNG 2 GO:0060043 regulation of cardiac muscle cell proliferation 2/1036 57/18670 0.8325 0.9261 0.8178 TGFBR2/TGFBR3 2 GO:0071398 cellular response to fatty acid 2/1036 57/18670 0.8325 0.9261 0.8178 PTGER4/AKR1C3 2 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 2/1036 57/18670 0.8325 0.9261 0.8178 PCNA/BTG2 2 GO:1900408 negative regulation of cellular response to oxidative stress 2/1036 57/18670 0.8325 0.9261 0.8178 FYN/PDE8A 2 GO:1900544 positive regulation of purine nucleotide metabolic process 2/1036 57/18670 0.8325 0.9261 0.8178 PGK1/IFNG 2 GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 2/1036 57/18670 0.8325 0.9261 0.8178 PCNA/BTG2 2 GO:0007269 neurotransmitter secretion 7/1036 169/18670 0.8344 0.9269 0.8185 ATP2A2/KMO/P2RX1/SV2A/DNM1L/CHRM2/GAD2 7 GO:0060761 negative regulation of response to cytokine stimulus 3/1036 81/18670 0.8344 0.9269 0.8185 CCL5/IL6/PIAS4 3 GO:0050673 epithelial cell proliferation 20/1036 434/18670 0.8344 0.9269 0.8185 MYC/CCL5/CCR3/PPP1R16B/ITGA4/WFDC1/ZFP36/HTRA1/MAGED1/TNF/TGFBR3/PHB2/PRKX/BCL11B/XBP1/SULF1/HMGN1/AIMP1/STK11/CCL11 20 GO:0001523 retinoid metabolic process 4/1036 104/18670 0.8357 0.9269 0.8185 LRP1/AKR1B1/AKR1C3/RDH16 4 GO:0007218 neuropeptide signaling pathway 4/1036 104/18670 0.8357 0.9269 0.8185 LTB4R/NTSR1/GLRA1/NMU 4 GO:0008643 carbohydrate transport 6/1036 148/18670 0.8362 0.9269 0.8185 SLC35D1/IL1B/SLC35A5/TNF/SLC35A1/PIK3R1 6 GO:0051592 response to calcium ion 6/1036 148/18670 0.8362 0.9269 0.8185 CPNE6/TRPM2/CPNE3/KCNH1/AKR1C3/MCOLN1 6 GO:0099643 signal release from synapse 7/1036 170/18670 0.8387 0.9269 0.8185 ATP2A2/KMO/P2RX1/SV2A/DNM1L/CHRM2/GAD2 7 GO:0001975 response to amphetamine 1/1036 32/18670 0.8393 0.9269 0.8185 SOD1 1 GO:0006505 GPI anchor metabolic process 1/1036 32/18670 0.8393 0.9269 0.8185 PGAP1 1 GO:0008210 estrogen metabolic process 1/1036 32/18670 0.8393 0.9269 0.8185 CYP2C9 1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/1036 32/18670 0.8393 0.9269 0.8185 CLIC2 1 GO:0033006 regulation of mast cell activation involved in immune response 1/1036 32/18670 0.8393 0.9269 0.8185 SPHK2 1 GO:0042491 inner ear auditory receptor cell differentiation 1/1036 32/18670 0.8393 0.9269 0.8185 SOD1 1 GO:0042573 retinoic acid metabolic process 1/1036 32/18670 0.8393 0.9269 0.8185 AKR1C3 1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1/1036 32/18670 0.8393 0.9269 0.8185 ATG14 1 GO:0045922 negative regulation of fatty acid metabolic process 1/1036 32/18670 0.8393 0.9269 0.8185 INSIG1 1 GO:0046039 GTP metabolic process 1/1036 32/18670 0.8393 0.9269 0.8185 MFN1 1 GO:0048741 skeletal muscle fiber development 1/1036 32/18670 0.8393 0.9269 0.8185 HDAC4 1 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1/1036 32/18670 0.8393 0.9269 0.8185 KMO 1 GO:0055022 negative regulation of cardiac muscle tissue growth 1/1036 32/18670 0.8393 0.9269 0.8185 TGFBR2 1 GO:0061117 negative regulation of heart growth 1/1036 32/18670 0.8393 0.9269 0.8185 TGFBR2 1 GO:0061311 cell surface receptor signaling pathway involved in heart development 1/1036 32/18670 0.8393 0.9269 0.8185 ACVR1 1 GO:0070286 axonemal dynein complex assembly 1/1036 32/18670 0.8393 0.9269 0.8185 ZMYND10 1 GO:0070570 regulation of neuron projection regeneration 1/1036 32/18670 0.8393 0.9269 0.8185 LRP1 1 GO:0071353 cellular response to interleukin-4 1/1036 32/18670 0.8393 0.9269 0.8185 XBP1 1 GO:0090504 epiboly 1/1036 32/18670 0.8393 0.9269 0.8185 CLASP1 1 GO:0099623 regulation of cardiac muscle cell membrane repolarization 1/1036 32/18670 0.8393 0.9269 0.8185 KCNQ1 1 GO:1900745 positive regulation of p38MAPK cascade 1/1036 32/18670 0.8393 0.9269 0.8185 IL1B 1 GO:1903955 positive regulation of protein targeting to mitochondrion 1/1036 32/18670 0.8393 0.9269 0.8185 CSNK2A2 1 GO:1904467 regulation of tumor necrosis factor secretion 1/1036 32/18670 0.8393 0.9269 0.8185 IFNG 1 GO:1905508 protein localization to microtubule organizing center 1/1036 32/18670 0.8393 0.9269 0.8185 PCM1 1 GO:2000780 negative regulation of double-strand break repair 1/1036 32/18670 0.8393 0.9269 0.8185 POLQ 1 GO:0035306 positive regulation of dephosphorylation 2/1036 58/18670 0.8397 0.9269 0.8185 IFNG/PPP1R16B 2 GO:0035904 aorta development 2/1036 58/18670 0.8397 0.9269 0.8185 LRP1/AP2B1 2 GO:0071385 cellular response to glucocorticoid stimulus 2/1036 58/18670 0.8397 0.9269 0.8185 ZFP36/ANXA1 2 GO:1904589 regulation of protein import 2/1036 58/18670 0.8397 0.9269 0.8185 IFNG/PIK3R1 2 GO:0040013 negative regulation of locomotion 18/1036 396/18670 0.8398 0.9269 0.8185 FLCN/GPR18/RRAS/ARHGAP4/RECK/WAS/LRP1/SEMA4G/SULF1/ELANE/SEMA3G/PTGER4/CLASP1/CITED2/CCL25/ADAM15/SLAMF8/BCR 18 GO:0030279 negative regulation of ossification 3/1036 82/18670 0.8405 0.9274 0.8189 TNF/HDAC4/GFRA4 3 GO:0050773 regulation of dendrite development 6/1036 149/18670 0.8408 0.9276 0.8191 CAPRIN2/DNM1L/TMEM106B/STK11/DBN1/CAPRIN1 6 GO:0007009 plasma membrane organization 4/1036 105/18670 0.8412 0.9278 0.8193 ATP2A2/CXCR4/EHD2/SOD1 4 GO:0010634 positive regulation of epithelial cell migration 7/1036 171/18670 0.843 0.9296 0.8209 IFNG/TGFBR2/CAPN7/ANXA1/PIK3C2A/CLASP1/FGF18 7 GO:0034763 negative regulation of transmembrane transport 5/1036 128/18670 0.8447 0.9297 0.8209 IL1B/CLIC2/NTSR1/TNF/YWHAQ 5 GO:0007338 single fertilization 6/1036 150/18670 0.8453 0.9297 0.8209 FOLR3/CCT7/CCT2/GLRA1/CD9/CATSPERG 6 GO:0007219 Notch signaling pathway 8/1036 193/18670 0.8459 0.9297 0.8209 MYC/TGFBR2/POGLUT1/APH1B/RBM15/TIMP4/WDR12/ZBTB7A 8 GO:2000106 regulation of leukocyte apoptotic process 3/1036 83/18670 0.8464 0.9297 0.8209 CCL5/PRKCQ/ANXA1 3 GO:0031102 neuron projection regeneration 2/1036 59/18670 0.8466 0.9297 0.8209 MTR/LRP1 2 GO:0032732 positive regulation of interleukin-1 production 2/1036 59/18670 0.8466 0.9297 0.8209 IFNG/MALT1 2 GO:0043388 positive regulation of DNA binding 2/1036 59/18670 0.8466 0.9297 0.8209 PARP1/IFNG 2 GO:0045824 negative regulation of innate immune response 2/1036 59/18670 0.8466 0.9297 0.8209 CD96/SLAMF8 2 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 2/1036 59/18670 0.8466 0.9297 0.8209 PCNA/BTG2 2 GO:0097755 positive regulation of blood vessel diameter 2/1036 59/18670 0.8466 0.9297 0.8209 SOD1/ATG5 2 GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 2/1036 59/18670 0.8466 0.9297 0.8209 PCNA/BTG2 2 GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 2/1036 59/18670 0.8466 0.9297 0.8209 PCNA/BTG2 2 GO:1902883 negative regulation of response to oxidative stress 2/1036 59/18670 0.8466 0.9297 0.8209 FYN/PDE8A 2 GO:0140013 meiotic nuclear division 7/1036 172/18670 0.8472 0.9297 0.8209 MYBL1/CDC25B/LIF/FBXO5/UBB/TERF1/SMC2 7 GO:0043588 skin development 19/1036 419/18670 0.8481 0.9297 0.8209 SOS1/PRKCH/ADAMTS2/GNAS/ITGA6/CAPN1/ZFP36/KRT9/TNF/ANXA1/BCL11B/NCOA3/TGM3/SOX21/AKR1C3/ITGB4/KLK13/KRT76/BCR 19 GO:0006370 7-methylguanosine mRNA capping 1/1036 33/18670 0.8483 0.9297 0.8209 GTF2H3 1 GO:0010039 response to iron ion 1/1036 33/18670 0.8483 0.9297 0.8209 ABAT 1 GO:0010092 specification of animal organ identity 1/1036 33/18670 0.8483 0.9297 0.8209 SMARCD3 1 GO:0010737 protein kinase A signaling 1/1036 33/18670 0.8483 0.9297 0.8209 PRKACB 1 GO:0014072 response to isoquinoline alkaloid 1/1036 33/18670 0.8483 0.9297 0.8209 CXCR4 1 GO:0016486 peptide hormone processing 1/1036 33/18670 0.8483 0.9297 0.8209 CTSG 1 GO:0019692 deoxyribose phosphate metabolic process 1/1036 33/18670 0.8483 0.9297 0.8209 DERA 1 GO:0035115 embryonic forelimb morphogenesis 1/1036 33/18670 0.8483 0.9297 0.8209 RECK 1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 1/1036 33/18670 0.8483 0.9297 0.8209 ATF3 1 GO:0042339 keratan sulfate metabolic process 1/1036 33/18670 0.8483 0.9297 0.8209 B3GNT2 1 GO:0042407 cristae formation 1/1036 33/18670 0.8483 0.9297 0.8209 CHCHD3 1 GO:0043278 response to morphine 1/1036 33/18670 0.8483 0.9297 0.8209 CXCR4 1 GO:0048854 brain morphogenesis 1/1036 33/18670 0.8483 0.9297 0.8209 SOS1 1 GO:1902692 regulation of neuroblast proliferation 1/1036 33/18670 0.8483 0.9297 0.8209 SMARCD3 1 GO:2001038 regulation of cellular response to drug 1/1036 33/18670 0.8483 0.9297 0.8209 PDE8A 1 GO:0019935 cyclic-nucleotide-mediated signaling 9/1036 215/18670 0.8493 0.9306 0.8218 CXCL11/GNAS/CRTC3/CHGA/PRKAR2B/PTGER4/GHRHR/ADNP/NDUFS4 9 GO:0034754 cellular hormone metabolic process 5/1036 129/18670 0.8495 0.9306 0.8218 FDX1/CYP2C9/AKR1B1/AKR1C3/RDH16 5 GO:0007015 actin filament organization 18/1036 400/18670 0.851 0.9322 0.8231 RHOH/NCK1/ARHGAP17/RASA1/ADD3/MICAL1/WAS/CD2AP/PSTPIP1/EMP2/ACTN1/CCL11/PTGER4/CLASP1/DBN1/HAX1/SH3BP1/PIK3R1 18 GO:0010469 regulation of signaling receptor activity 7/1036 173/18670 0.8513 0.9322 0.8232 IFNG/CAPN1/CBLB/FNTA/RWDD1/NCOA3/NCAPG2 7 GO:0043502 regulation of muscle adaptation 4/1036 107/18670 0.8515 0.9323 0.8233 PARP1/ATP2A2/TNNI1/HDAC4 4 GO:0014910 regulation of smooth muscle cell migration 3/1036 84/18670 0.8521 0.9326 0.8235 CCL5/LRP1/HDAC4 3 GO:0007050 cell cycle arrest 10/1036 237/18670 0.853 0.9326 0.8235 PCNA/MYC/IFNG/IL12B/BTG2/MSH2/STK11/PRR11/CGRRF1/STRADA 10 GO:0018149 peptide cross-linking 2/1036 60/18670 0.8532 0.9326 0.8235 ANXA1/TGM3 2 GO:0046324 regulation of glucose import 2/1036 60/18670 0.8532 0.9326 0.8235 TNF/PIK3R1 2 GO:0051893 regulation of focal adhesion assembly 2/1036 60/18670 0.8532 0.9326 0.8235 LRP1/CLASP1 2 GO:0090109 regulation of cell-substrate junction assembly 2/1036 60/18670 0.8532 0.9326 0.8235 LRP1/CLASP1 2 GO:0090342 regulation of cell aging 2/1036 60/18670 0.8532 0.9326 0.8235 EEF1E1/FBXO5 2 GO:0120193 tight junction organization 2/1036 60/18670 0.8532 0.9326 0.8235 PRKCH/TNF 2 GO:0007286 spermatid development 6/1036 152/18670 0.854 0.9333 0.8241 CEP57/DLD/DYNLL1/PSME4/PLA2G3/UBE2J1 6 GO:0030004 cellular monovalent inorganic cation homeostasis 4/1036 108/18670 0.8565 0.9338 0.8245 MAPK3/ATP1B1/CA7/SLAMF8 4 GO:0060348 bone development 9/1036 217/18670 0.8566 0.9338 0.8245 TGFBR2/GNAS/INSIG1/BMPR1B/SULF1/RARA/PTGER4/PRPSAP2/FGF18 9 GO:0000737 DNA catabolic process, endonucleolytic 1/1036 34/18670 0.8567 0.9338 0.8245 IL6 1 GO:0007435 salivary gland morphogenesis 1/1036 34/18670 0.8567 0.9338 0.8245 TNF 1 GO:0009452 7-methylguanosine RNA capping 1/1036 34/18670 0.8567 0.9338 0.8245 GTF2H3 1 GO:0010922 positive regulation of phosphatase activity 1/1036 34/18670 0.8567 0.9338 0.8245 IFNG 1 GO:0016601 Rac protein signal transduction 1/1036 34/18670 0.8567 0.9338 0.8245 AUTS2 1 GO:0018345 protein palmitoylation 1/1036 34/18670 0.8567 0.9338 0.8245 ZDHHC4 1 GO:0021522 spinal cord motor neuron differentiation 1/1036 34/18670 0.8567 0.9338 0.8245 LHX3 1 GO:0036260 RNA capping 1/1036 34/18670 0.8567 0.9338 0.8245 GTF2H3 1 GO:0036474 cell death in response to hydrogen peroxide 1/1036 34/18670 0.8567 0.9338 0.8245 PDE8A 1 GO:0045738 negative regulation of DNA repair 1/1036 34/18670 0.8567 0.9338 0.8245 POLQ 1 GO:0071875 adrenergic receptor signaling pathway 1/1036 34/18670 0.8567 0.9338 0.8245 CHGA 1 GO:0002028 regulation of sodium ion transport 3/1036 85/18670 0.8576 0.9345 0.8252 GPD1L/ATP1B1/RANGRF 3 GO:0051017 actin filament bundle assembly 6/1036 153/18670 0.8582 0.935 0.8256 ADD3/WAS/ACTN1/PTGER4/CLASP1/PIK3R1 6 GO:0001947 heart looping 2/1036 61/18670 0.8596 0.9357 0.8263 TGFBR2/TMED2 2 GO:0003170 heart valve development 2/1036 61/18670 0.8596 0.9357 0.8263 TGFBR2/ACVR1 2 GO:0006027 glycosaminoglycan catabolic process 2/1036 61/18670 0.8596 0.9357 0.8263 SGSH/PGLYRP4 2 GO:0030888 regulation of B cell proliferation 2/1036 61/18670 0.8596 0.9357 0.8263 CD38/GPR183 2 GO:0016064 immunoglobulin mediated immune response 9/1036 218/18670 0.8601 0.9359 0.8264 C1QBP/POU2F2/TNFSF13/HLA-DQB1/TNF/C8B/MSH2/TBX21/TRBC1 9 GO:0050807 regulation of synapse organization 9/1036 218/18670 0.8601 0.9359 0.8264 AMIGO2/FYN/TNF/CAPRIN2/DNM1L/DBN1/CAPRIN1/NTN1/ADNP 9 GO:0017156 calcium ion regulated exocytosis 6/1036 154/18670 0.8622 0.9367 0.8271 ARHGAP17/ATP2A2/P2RX1/SV2A/DNM1L/CHRM2 6 GO:0060291 long-term synaptic potentiation 3/1036 86/18670 0.8629 0.9367 0.8271 CALB2/SLC8A2/GRIN2D 3 GO:0001936 regulation of endothelial cell proliferation 7/1036 176/18670 0.863 0.9367 0.8271 CCR3/PPP1R16B/ITGA4/TNF/SULF1/AIMP1/CCL11 7 GO:0110053 regulation of actin filament organization 11/1036 261/18670 0.8632 0.9367 0.8271 NCK1/RASA1/ADD3/WAS/CCL11/PTGER4/CLASP1/DBN1/HAX1/SH3BP1/PIK3R1 11 GO:0009262 deoxyribonucleotide metabolic process 1/1036 35/18670 0.8647 0.9367 0.8271 DERA 1 GO:0014904 myotube cell development 1/1036 35/18670 0.8647 0.9367 0.8271 HDAC4 1 GO:0019076 viral release from host cell 1/1036 35/18670 0.8647 0.9367 0.8271 VPS37B 1 GO:0030262 apoptotic nuclear changes 1/1036 35/18670 0.8647 0.9367 0.8271 IL6 1 GO:0033363 secretory granule organization 1/1036 35/18670 0.8647 0.9367 0.8271 PLA2G3 1 GO:0035890 exit from host 1/1036 35/18670 0.8647 0.9367 0.8271 VPS37B 1 GO:0035891 exit from host cell 1/1036 35/18670 0.8647 0.9367 0.8271 VPS37B 1 GO:0035909 aorta morphogenesis 1/1036 35/18670 0.8647 0.9367 0.8271 LRP1 1 GO:0042462 eye photoreceptor cell development 1/1036 35/18670 0.8647 0.9367 0.8271 TRPM1 1 GO:0052126 movement in host environment 1/1036 35/18670 0.8647 0.9367 0.8271 VPS37B 1 GO:0052192 movement in environment of other organism involved in symbiotic interaction 1/1036 35/18670 0.8647 0.9367 0.8271 VPS37B 1 GO:0060338 regulation of type I interferon-mediated signaling pathway 1/1036 35/18670 0.8647 0.9367 0.8271 USP18 1 GO:0071108 protein K48-linked deubiquitination 1/1036 35/18670 0.8647 0.9367 0.8271 USP25 1 GO:0071312 cellular response to alkaloid 1/1036 35/18670 0.8647 0.9367 0.8271 CASP7 1 GO:0098801 regulation of renal system process 1/1036 35/18670 0.8647 0.9367 0.8271 EMP2 1 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 1/1036 35/18670 0.8647 0.9367 0.8271 PSMD10 1 GO:0002260 lymphocyte homeostasis 2/1036 62/18670 0.8657 0.9367 0.8271 SOS1/PMAIP1 2 GO:0003407 neural retina development 2/1036 62/18670 0.8657 0.9367 0.8271 SMARCD3/DSCAM 2 GO:0035082 axoneme assembly 2/1036 62/18670 0.8657 0.9367 0.8271 ZMYND10/PLA2G3 2 GO:0045453 bone resorption 2/1036 62/18670 0.8657 0.9367 0.8271 CD38/IL6 2 GO:0050433 regulation of catecholamine secretion 2/1036 62/18670 0.8657 0.9367 0.8271 ABAT/CHGA 2 GO:0051898 negative regulation of protein kinase B signaling 2/1036 62/18670 0.8657 0.9367 0.8271 FLCN/PPP2R5C 2 GO:0055025 positive regulation of cardiac muscle tissue development 2/1036 62/18670 0.8657 0.9367 0.8271 ERBB3/TGFBR3 2 GO:1901862 negative regulation of muscle tissue development 2/1036 62/18670 0.8657 0.9367 0.8271 TGFBR2/FLCN 2 GO:0016101 diterpenoid metabolic process 4/1036 110/18670 0.866 0.9368 0.8272 LRP1/AKR1B1/AKR1C3/RDH16 4 GO:0016050 vesicle organization 14/1036 325/18670 0.8685 0.9391 0.8293 CTSC/INSIG1/SCFD1/CD2AP/ANXA1/STX10/STX8/TBC1D4/FBXO5/VPS37B/PLA2G3/GOSR1/SEC24A/TMED2 14 GO:0045216 cell-cell junction organization 6/1036 156/18670 0.8701 0.9391 0.8293 FLCN/PRKCH/TNF/KIFC3/CD9/HEG1 6 GO:0019724 B cell mediated immunity 9/1036 221/18670 0.8702 0.9391 0.8293 C1QBP/POU2F2/TNFSF13/HLA-DQB1/TNF/C8B/MSH2/TBX21/TRBC1 9 GO:0022037 metencephalon development 4/1036 111/18670 0.8705 0.9391 0.8293 ABAT/RORA/HERC1/CD3E 4 GO:0031623 receptor internalization 4/1036 111/18670 0.8705 0.9391 0.8293 LDLRAP1/LRP1/CD9/AP2B1 4 GO:0002920 regulation of humoral immune response 5/1036 134/18670 0.8714 0.9391 0.8293 IL1B/C1QBP/TNF/C8B/CD5L 5 GO:0032273 positive regulation of protein polymerization 5/1036 134/18670 0.8714 0.9391 0.8293 NCK1/WAS/CCL11/CLASP1/TERF1 5 GO:0031571 mitotic G1 DNA damage checkpoint 2/1036 63/18670 0.8715 0.9391 0.8293 PCNA/BTG2 2 GO:0044819 mitotic G1/S transition checkpoint 2/1036 63/18670 0.8715 0.9391 0.8293 PCNA/BTG2 2 GO:0046530 photoreceptor cell differentiation 2/1036 63/18670 0.8715 0.9391 0.8293 DSCAM/TRPM1 2 GO:0000578 embryonic axis specification 1/1036 36/18670 0.8722 0.9391 0.8293 TMED2 1 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1/1036 36/18670 0.8722 0.9391 0.8293 CLIC2 1 GO:0030224 monocyte differentiation 1/1036 36/18670 0.8722 0.9391 0.8293 MYC 1 GO:0033572 transferrin transport 1/1036 36/18670 0.8722 0.9391 0.8293 MCOLN1 1 GO:0034314 Arp2/3 complex-mediated actin nucleation 1/1036 36/18670 0.8722 0.9391 0.8293 WAS 1 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 1/1036 36/18670 0.8722 0.9391 0.8293 SULF1 1 GO:0042554 superoxide anion generation 1/1036 36/18670 0.8722 0.9391 0.8293 SOD1 1 GO:0060428 lung epithelium development 1/1036 36/18670 0.8722 0.9391 0.8293 RCN3 1 GO:0071392 cellular response to estradiol stimulus 1/1036 36/18670 0.8722 0.9391 0.8293 NCOA3 1 GO:0071634 regulation of transforming growth factor beta production 1/1036 36/18670 0.8722 0.9391 0.8293 CD2AP 1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1/1036 36/18670 0.8722 0.9391 0.8293 CLIC2 1 GO:1903131 mononuclear cell differentiation 1/1036 36/18670 0.8722 0.9391 0.8293 MYC 1 GO:2001171 positive regulation of ATP biosynthetic process 1/1036 36/18670 0.8722 0.9391 0.8293 IFNG 1 GO:0097194 execution phase of apoptosis 3/1036 88/18670 0.8731 0.9399 0.83 IL6/CASP7/DNM1L 3 GO:0061572 actin filament bundle organization 6/1036 157/18670 0.8739 0.9406 0.8306 ADD3/WAS/ACTN1/PTGER4/CLASP1/PIK3R1 6 GO:0001938 positive regulation of endothelial cell proliferation 4/1036 112/18670 0.875 0.9408 0.8308 CCR3/PPP1R16B/ITGA4/CCL11 4 GO:0017158 regulation of calcium ion-dependent exocytosis 4/1036 112/18670 0.875 0.9408 0.8308 ATP2A2/P2RX1/DNM1L/CHRM2 4 GO:0043279 response to alkaloid 4/1036 112/18670 0.875 0.9408 0.8308 DHX15/ABAT/CASP7/CXCR4 4 GO:0070268 cornification 4/1036 112/18670 0.875 0.9408 0.8308 CAPN1/KRT9/KLK13/KRT76 4 GO:0098693 regulation of synaptic vesicle cycle 4/1036 112/18670 0.875 0.9408 0.8308 ATP2A2/P2RX1/DNM1L/CHRM2 4 GO:0006826 iron ion transport 2/1036 64/18670 0.8772 0.9409 0.8309 IFNG/MCOLN1 2 GO:0043297 apical junction assembly 2/1036 64/18670 0.8772 0.9409 0.8309 PRKCH/TNF 2 GO:0046782 regulation of viral transcription 2/1036 64/18670 0.8772 0.9409 0.8309 CCL5/ZFP36 2 GO:0050432 catecholamine secretion 2/1036 64/18670 0.8772 0.9409 0.8309 ABAT/CHGA 2 GO:0071466 cellular response to xenobiotic stimulus 7/1036 180/18670 0.8774 0.9409 0.8309 CRYZ/PCNA/RORA/AKR7A2/CYP2C9/MARC1/GSTA3 7 GO:2000146 negative regulation of cell motility 15/1036 349/18670 0.8775 0.9409 0.8309 FLCN/GPR18/RRAS/ARHGAP4/RECK/WAS/LRP1/SULF1/PTGER4/CLASP1/CITED2/CCL25/ADAM15/SLAMF8/BCR 15 GO:0048515 spermatid differentiation 6/1036 158/18670 0.8776 0.9409 0.8309 CEP57/DLD/DYNLL1/PSME4/PLA2G3/UBE2J1 6 GO:0006497 protein lipidation 3/1036 89/18670 0.8779 0.9409 0.8309 ZDHHC4/PGAP1/ATG5 3 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 3/1036 89/18670 0.8779 0.9409 0.8309 CHRM5/RGS1/CHRM2 3 GO:0061053 somite development 3/1036 89/18670 0.8779 0.9409 0.8309 POGLUT1/XRCC2/TMED2 3 GO:1902806 regulation of cell cycle G1/S phase transition 8/1036 202/18670 0.8782 0.9409 0.8309 PCNA/BRD7/DACT1/BTG2/ANKRD17/ANXA1/PHB2/TMEM14B 8 GO:0001662 behavioral fear response 1/1036 37/18670 0.8793 0.9409 0.8309 VDAC3 1 GO:0006623 protein targeting to vacuole 1/1036 37/18670 0.8793 0.9409 0.8309 VPS37B 1 GO:0006921 cellular component disassembly involved in execution phase of apoptosis 1/1036 37/18670 0.8793 0.9409 0.8309 IL6 1 GO:0014912 negative regulation of smooth muscle cell migration 1/1036 37/18670 0.8793 0.9409 0.8309 LRP1 1 GO:0031076 embryonic camera-type eye development 1/1036 37/18670 0.8793 0.9409 0.8309 RARA 1 GO:0031935 regulation of chromatin silencing 1/1036 37/18670 0.8793 0.9409 0.8309 HIRA 1 GO:0032941 secretion by tissue 1/1036 37/18670 0.8793 0.9409 0.8309 ATG5 1 GO:0034405 response to fluid shear stress 1/1036 37/18670 0.8793 0.9409 0.8309 CITED2 1 GO:0043029 T cell homeostasis 1/1036 37/18670 0.8793 0.9409 0.8309 PMAIP1 1 GO:0043114 regulation of vascular permeability 1/1036 37/18670 0.8793 0.9409 0.8309 BCR 1 GO:0046839 phospholipid dephosphorylation 1/1036 37/18670 0.8793 0.9409 0.8309 CHRM5 1 GO:0051567 histone H3-K9 methylation 1/1036 37/18670 0.8793 0.9409 0.8309 ATRX 1 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1/1036 37/18670 0.8793 0.9409 0.8309 CLIC2 1 GO:0022408 negative regulation of cell-cell adhesion 7/1036 181/18670 0.8808 0.9424 0.8322 ABAT/PTPN22/ANXA1/TBX21/MBP/CD9/CCL25 7 GO:0030641 regulation of cellular pH 3/1036 90/18670 0.8826 0.943 0.8327 MAPK3/CA7/SLAMF8 3 GO:1901379 regulation of potassium ion transmembrane transport 3/1036 90/18670 0.8826 0.943 0.8327 ATP1B1/KCNS1/KCNQ1 3 GO:0006026 aminoglycan catabolic process 2/1036 65/18670 0.8826 0.943 0.8327 SGSH/PGLYRP4 2 GO:0009247 glycolipid biosynthetic process 2/1036 65/18670 0.8826 0.943 0.8327 ST3GAL5/PGAP1 2 GO:1901016 regulation of potassium ion transmembrane transporter activity 2/1036 65/18670 0.8826 0.943 0.8327 ATP1B1/KCNS1 2 GO:0009566 fertilization 7/1036 182/18670 0.8842 0.943 0.8327 FOLR3/CCT7/UBE2Q1/CCT2/GLRA1/CD9/CATSPERG 7 GO:0034764 positive regulation of transmembrane transport 8/1036 204/18670 0.8846 0.943 0.8327 CXCL11/ABCB1/IFNG/NTSR1/ATP1B1/EHD3/KCNQ1/PIK3R1 8 GO:0002209 behavioral defense response 1/1036 38/18670 0.886 0.943 0.8327 VDAC3 1 GO:0007190 activation of adenylate cyclase activity 1/1036 38/18670 0.886 0.943 0.8327 GHRHR 1 GO:0007340 acrosome reaction 1/1036 38/18670 0.886 0.943 0.8327 GLRA1 1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 1/1036 38/18670 0.886 0.943 0.8327 HSPB6 1 GO:0010831 positive regulation of myotube differentiation 1/1036 38/18670 0.886 0.943 0.8327 EHD2 1 GO:0010939 regulation of necrotic cell death 1/1036 38/18670 0.886 0.943 0.8327 BIRC3 1 GO:0015682 ferric iron transport 1/1036 38/18670 0.886 0.943 0.8327 MCOLN1 1 GO:0046326 positive regulation of glucose import 1/1036 38/18670 0.886 0.943 0.8327 PIK3R1 1 GO:0046676 negative regulation of insulin secretion 1/1036 38/18670 0.886 0.943 0.8327 CHGA 1 GO:0050892 intestinal absorption 1/1036 38/18670 0.886 0.943 0.8327 KCNQ1 1 GO:0051693 actin filament capping 1/1036 38/18670 0.886 0.943 0.8327 ADD3 1 GO:0060045 positive regulation of cardiac muscle cell proliferation 1/1036 38/18670 0.886 0.943 0.8327 TGFBR3 1 GO:0060416 response to growth hormone 1/1036 38/18670 0.886 0.943 0.8327 PIK3R1 1 GO:0071604 transforming growth factor beta production 1/1036 38/18670 0.886 0.943 0.8327 CD2AP 1 GO:0072512 trivalent inorganic cation transport 1/1036 38/18670 0.886 0.943 0.8327 MCOLN1 1 GO:0086091 regulation of heart rate by cardiac conduction 1/1036 38/18670 0.886 0.943 0.8327 KCNQ1 1 GO:1902742 apoptotic process involved in development 1/1036 38/18670 0.886 0.943 0.8327 SPI1 1 GO:1903523 negative regulation of blood circulation 1/1036 38/18670 0.886 0.943 0.8327 ATP2A2 1 GO:2000279 negative regulation of DNA biosynthetic process 1/1036 38/18670 0.886 0.943 0.8327 TERF1 1 GO:0030510 regulation of BMP signaling pathway 3/1036 91/18670 0.8871 0.9439 0.8335 FKBP8/HTRA1/SULF1 3 GO:0021953 central nervous system neuron differentiation 7/1036 183/18670 0.8874 0.9439 0.8335 RORA/BTG2/HERC1/LHX3/MAP2/BCL11B/UBB 7 GO:0030449 regulation of complement activation 4/1036 115/18670 0.8874 0.9439 0.8335 IL1B/C1QBP/C8B/CD5L 4 GO:0021872 forebrain generation of neurons 2/1036 66/18670 0.8878 0.9439 0.8335 BCL11B/UBB 2 GO:0051926 negative regulation of calcium ion transport 2/1036 66/18670 0.8878 0.9439 0.8335 CLIC2/NTSR1 2 GO:0050803 regulation of synapse structure or activity 9/1036 227/18670 0.8886 0.9447 0.8342 AMIGO2/FYN/TNF/CAPRIN2/DNM1L/DBN1/CAPRIN1/NTN1/ADNP 9 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 5/1036 139/18670 0.8905 0.9456 0.835 CXCL11/GNAS/CHGA/PTGER4/GHRHR 5 GO:0016571 histone methylation 5/1036 139/18670 0.8905 0.9456 0.835 AUTS2/CTR9/FBL/ATRX/SATB1 5 GO:2000045 regulation of G1/S transition of mitotic cell cycle 7/1036 184/18670 0.8906 0.9456 0.835 PCNA/BRD7/DACT1/BTG2/ANKRD17/ANXA1/TMEM14B 7 GO:0050679 positive regulation of epithelial cell proliferation 8/1036 206/18670 0.8907 0.9456 0.835 MYC/CCL5/CCR3/PPP1R16B/ITGA4/HTRA1/XBP1/CCL11 8 GO:0006661 phosphatidylinositol biosynthetic process 4/1036 116/18670 0.8913 0.9456 0.835 PIK3CA/PIK3C2A/PGAP1/PIK3R1 4 GO:2000257 regulation of protein activation cascade 4/1036 116/18670 0.8913 0.9456 0.835 IL1B/C1QBP/C8B/CD5L 4 GO:0030336 negative regulation of cell migration 14/1036 334/18670 0.8916 0.9456 0.835 FLCN/GPR18/RRAS/ARHGAP4/RECK/LRP1/SULF1/PTGER4/CLASP1/CITED2/CCL25/ADAM15/SLAMF8/BCR 14 GO:0002251 organ or tissue specific immune response 1/1036 39/18670 0.8923 0.9456 0.835 IL6 1 GO:0042417 dopamine metabolic process 1/1036 39/18670 0.8923 0.9456 0.835 ABAT 1 GO:0060306 regulation of membrane repolarization 1/1036 39/18670 0.8923 0.9456 0.835 KCNQ1 1 GO:0072529 pyrimidine-containing compound catabolic process 1/1036 39/18670 0.8923 0.9456 0.835 APOBEC3G 1 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1/1036 39/18670 0.8923 0.9456 0.835 PIAS4 1 GO:2000648 positive regulation of stem cell proliferation 1/1036 39/18670 0.8923 0.9456 0.835 SMARCD3 1 GO:0032387 negative regulation of intracellular transport 2/1036 67/18670 0.8927 0.9456 0.835 INSIG1/UBE2J1 2 GO:0046365 monosaccharide catabolic process 2/1036 67/18670 0.8927 0.9456 0.835 PGK1/PFKP 2 GO:0060038 cardiac muscle cell proliferation 2/1036 67/18670 0.8927 0.9456 0.835 TGFBR2/TGFBR3 2 GO:0061371 determination of heart left/right asymmetry 2/1036 67/18670 0.8927 0.9456 0.835 TGFBR2/TMED2 2 GO:1903391 regulation of adherens junction organization 2/1036 67/18670 0.8927 0.9456 0.835 LRP1/CLASP1 2 GO:0099003 vesicle-mediated transport in synapse 8/1036 207/18670 0.8936 0.9464 0.8357 ATP2A2/TMEM230/P2RX1/SV2A/MAP2/DNM1L/CHRM2/AP2B1 8 GO:0031214 biomineral tissue development 6/1036 163/18670 0.8948 0.9475 0.8366 ACVR1/ASGR2/BMPR1B/AMBN/FBXO5/SLC20A1 6 GO:0007613 memory 4/1036 117/18670 0.8951 0.9476 0.8368 HRH2/SLC8A2/JPH3/ADNP 4 GO:0035249 synaptic transmission, glutamatergic 3/1036 93/18670 0.8956 0.9476 0.8368 KMO/P2RX1/TNF 3 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 11/1036 273/18670 0.897 0.9476 0.8368 TGFBR2/AMIGO2/ACVR1/PLXNB2/KIFAP3/PCDHB13/MPZ/MBP/DSCAM/PCDHB6/CLDN15 11 GO:0035914 skeletal muscle cell differentiation 2/1036 68/18670 0.8975 0.9476 0.8368 BTG2/ATF3 2 GO:0046323 glucose import 2/1036 68/18670 0.8975 0.9476 0.8368 TNF/PIK3R1 2 GO:0051965 positive regulation of synapse assembly 2/1036 68/18670 0.8975 0.9476 0.8368 AMIGO2/ADNP 2 GO:0000183 chromatin silencing at rDNA 1/1036 40/18670 0.8983 0.9476 0.8368 SMARCA5 1 GO:0001941 postsynaptic membrane organization 1/1036 40/18670 0.8983 0.9476 0.8368 FNTA 1 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1/1036 40/18670 0.8983 0.9476 0.8368 TBX21 1 GO:0009268 response to pH 1/1036 40/18670 0.8983 0.9476 0.8368 MCOLN1 1 GO:0014046 dopamine secretion 1/1036 40/18670 0.8983 0.9476 0.8368 ABAT 1 GO:0014059 regulation of dopamine secretion 1/1036 40/18670 0.8983 0.9476 0.8368 ABAT 1 GO:0035315 hair cell differentiation 1/1036 40/18670 0.8983 0.9476 0.8368 SOD1 1 GO:0042596 fear response 1/1036 40/18670 0.8983 0.9476 0.8368 VDAC3 1 GO:0046621 negative regulation of organ growth 1/1036 40/18670 0.8983 0.9476 0.8368 TGFBR2 1 GO:0071470 cellular response to osmotic stress 1/1036 40/18670 0.8983 0.9476 0.8368 AKR1B1 1 GO:0071548 response to dexamethasone 1/1036 40/18670 0.8983 0.9476 0.8368 PCNA 1 GO:0090207 regulation of triglyceride metabolic process 1/1036 40/18670 0.8983 0.9476 0.8368 ATG14 1 GO:0001667 ameboidal-type cell migration 20/1036 461/18670 0.8985 0.9476 0.8368 ARID5B/IFNG/TGFBR2/LGALS8/C1QBP/CAPN7/ITGA4/ARHGAP4/ACVR1/ANXA1/SEMA4G/PRKX/ARHGEF7/EMP2/PIK3CA/SEMA3G/PIK3C2A/CLASP1/SH3BP1/FGF18 20 GO:0006898 receptor-mediated endocytosis 13/1036 316/18670 0.8985 0.9476 0.8368 TGFBR2/ITGA4/LDLRAP1/HP/CD2AP/LRP1/ASGR1/LMBR1L/CD163/PDLIM7/CD9/STAB1/AP2B1 13 GO:0042158 lipoprotein biosynthetic process 3/1036 94/18670 0.8996 0.9483 0.8374 ZDHHC4/PGAP1/ATG5 3 GO:0070167 regulation of biomineral tissue development 3/1036 94/18670 0.8996 0.9483 0.8374 ACVR1/BMPR1B/FBXO5 3 GO:0019933 cAMP-mediated signaling 7/1036 187/18670 0.8997 0.9483 0.8374 CXCL11/GNAS/CRTC3/CHGA/PTGER4/GHRHR/NDUFS4 7 GO:0007163 establishment or maintenance of cell polarity 8/1036 210/18670 0.9021 0.9506 0.8394 RHOH/MAP2/PARVA/NDC80/STK11/CLASP1/SH3BP1/FEZ1 8 GO:0060337 type I interferon signaling pathway 3/1036 95/18670 0.9035 0.9508 0.8396 IFIT2/RSAD2/USP18 3 GO:0071357 cellular response to type I interferon 3/1036 95/18670 0.9035 0.9508 0.8396 IFIT2/RSAD2/USP18 3 GO:0006308 DNA catabolic process 1/1036 41/18670 0.904 0.9508 0.8396 IL6 1 GO:0010664 negative regulation of striated muscle cell apoptotic process 1/1036 41/18670 0.904 0.9508 0.8396 HSPB6 1 GO:0030835 negative regulation of actin filament depolymerization 1/1036 41/18670 0.904 0.9508 0.8396 ADD3 1 GO:0040019 positive regulation of embryonic development 1/1036 41/18670 0.904 0.9508 0.8396 CLASP1 1 GO:0048286 lung alveolus development 1/1036 41/18670 0.904 0.9508 0.8396 LIF 1 GO:0090224 regulation of spindle organization 1/1036 41/18670 0.904 0.9508 0.8396 RNF4 1 GO:0098815 modulation of excitatory postsynaptic potential 1/1036 41/18670 0.904 0.9508 0.8396 EIF4A3 1 GO:1900117 regulation of execution phase of apoptosis 1/1036 41/18670 0.904 0.9508 0.8396 IL6 1 GO:0048738 cardiac muscle tissue development 9/1036 233/18670 0.9049 0.9515 0.8402 TGFBR2/ACVR1/NDUFV2/TNNI1/ERBB3/TGFBR3/RARA/HEG1/ATG5 9 GO:0051966 regulation of synaptic transmission, glutamatergic 2/1036 70/18670 0.9064 0.9528 0.8413 KMO/TNF 2 GO:0061515 myeloid cell development 2/1036 70/18670 0.9064 0.9528 0.8413 RHAG/ZBTB7A 2 GO:0010660 regulation of muscle cell apoptotic process 3/1036 96/18670 0.9073 0.9533 0.8418 IFNG/IL12B/HSPB6 3 GO:0019217 regulation of fatty acid metabolic process 3/1036 96/18670 0.9073 0.9533 0.8418 IL1B/INSIG1/ANXA1 3 GO:0010613 positive regulation of cardiac muscle hypertrophy 1/1036 42/18670 0.9093 0.9549 0.8432 PARP1 1 GO:0033003 regulation of mast cell activation 1/1036 42/18670 0.9093 0.9549 0.8432 SPHK2 1 GO:2001222 regulation of neuron migration 1/1036 42/18670 0.9093 0.9549 0.8432 PLXNB2 1 GO:0042440 pigment metabolic process 2/1036 71/18670 0.9106 0.956 0.8442 PRPS1/APRT 2 GO:0048709 oligodendrocyte differentiation 3/1036 97/18670 0.911 0.956 0.8442 DAAM2/CXCR4/CD9 3 GO:0051591 response to cAMP 3/1036 97/18670 0.911 0.956 0.8442 FDX1/KCNQ1/NDUFS4 3 GO:0006904 vesicle docking involved in exocytosis 1/1036 43/18670 0.9144 0.9587 0.8465 SCFD1 1 GO:0014742 positive regulation of muscle hypertrophy 1/1036 43/18670 0.9144 0.9587 0.8465 PARP1 1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 1/1036 43/18670 0.9144 0.9587 0.8465 SH3BP1 1 GO:0045746 negative regulation of Notch signaling pathway 1/1036 43/18670 0.9144 0.9587 0.8465 ZBTB7A 1 GO:0055026 negative regulation of cardiac muscle tissue development 1/1036 43/18670 0.9144 0.9587 0.8465 TGFBR2 1 GO:0050808 synapse organization 17/1036 408/18670 0.9151 0.9593 0.8471 AMIGO2/FYN/TNF/FNTA/CAPRIN2/PLXNB2/DNM1L/PCDHB13/ACTN1/CACNB4/GABRB2/DBN1/CAPRIN1/DSCAM/PCDHB6/NTN1/ADNP 17 GO:0043433 negative regulation of DNA-binding transcription factor activity 6/1036 170/18670 0.9154 0.9593 0.8471 CAT/TRIM37/PHB2/PIAS4/HDAC4/PSMD10 6 GO:0030838 positive regulation of actin filament polymerization 3/1036 99/18670 0.9178 0.9608 0.8485 NCK1/WAS/CCL11 3 GO:0034340 response to type I interferon 3/1036 99/18670 0.9178 0.9608 0.8485 IFIT2/RSAD2/USP18 3 GO:0000910 cytokinesis 6/1036 171/18670 0.918 0.9608 0.8485 FLCN/AURKC/CDC25B/RASA1/CKAP2/PRC1 6 GO:0000281 mitotic cytokinesis 2/1036 73/18670 0.9185 0.9608 0.8485 RASA1/CKAP2 2 GO:0072401 signal transduction involved in DNA integrity checkpoint 2/1036 73/18670 0.9185 0.9608 0.8485 PCNA/BTG2 2 GO:0072422 signal transduction involved in DNA damage checkpoint 2/1036 73/18670 0.9185 0.9608 0.8485 PCNA/BTG2 2 GO:0035107 appendage morphogenesis 5/1036 148/18670 0.9188 0.9608 0.8485 GNAS/RECK/BMPR1B/ZBTB16/ATRX 5 GO:0035108 limb morphogenesis 5/1036 148/18670 0.9188 0.9608 0.8485 GNAS/RECK/BMPR1B/ZBTB16/ATRX 5 GO:0007212 dopamine receptor signaling pathway 1/1036 44/18670 0.9191 0.9608 0.8485 GNAS 1 GO:0010828 positive regulation of glucose transmembrane transport 1/1036 44/18670 0.9191 0.9608 0.8485 PIK3R1 1 GO:0014003 oligodendrocyte development 1/1036 44/18670 0.9191 0.9608 0.8485 CD9 1 GO:0035307 positive regulation of protein dephosphorylation 1/1036 44/18670 0.9191 0.9608 0.8485 PPP1R16B 1 GO:0090382 phagosome maturation 1/1036 44/18670 0.9191 0.9608 0.8485 SLAMF8 1 GO:0030216 keratinocyte differentiation 12/1036 305/18670 0.9204 0.962 0.8495 PRKCH/CAPN1/ZFP36/KRT9/ANXA1/BCL11B/NCOA3/TGM3/AKR1C3/KLK13/KRT76/BCR 12 GO:0010657 muscle cell apoptotic process 3/1036 100/18670 0.9211 0.9623 0.8498 IFNG/IL12B/HSPB6 3 GO:0055024 regulation of cardiac muscle tissue development 3/1036 100/18670 0.9211 0.9623 0.8498 TGFBR2/ERBB3/TGFBR3 3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 4/1036 125/18670 0.9215 0.9625 0.8499 PCNA/BRD7/DACT1/BTG2 4 GO:0021700 developmental maturation 11/1036 284/18670 0.9216 0.9625 0.8499 POU2F2/CDC25B/DLD/RECK/ANKRD17/XBP1/LYL1/FBXO5/GHRHR/IL15/ZBTB7A 11 GO:0001895 retina homeostasis 2/1036 74/18670 0.9222 0.9627 0.8501 LYZ/SOD1 2 GO:0072395 signal transduction involved in cell cycle checkpoint 2/1036 74/18670 0.9222 0.9627 0.8501 PCNA/BTG2 2 GO:0002820 negative regulation of adaptive immune response 1/1036 45/18670 0.9236 0.9635 0.8508 TBX21 1 GO:0014014 negative regulation of gliogenesis 1/1036 45/18670 0.9236 0.9635 0.8508 DAAM2 1 GO:0090278 negative regulation of peptide hormone secretion 1/1036 45/18670 0.9236 0.9635 0.8508 CHGA 1 GO:1900271 regulation of long-term synaptic potentiation 1/1036 45/18670 0.9236 0.9635 0.8508 CALB2 1 GO:0002455 humoral immune response mediated by circulating immunoglobulin 5/1036 150/18670 0.9241 0.9638 0.8511 C1QBP/HLA-DQB1/TNF/C8B/TRBC1 5 GO:0072376 protein activation cascade 7/1036 198/18670 0.9277 0.9649 0.852 IL1B/C1QBP/F12/C8B/FCN1/CD5L/TRBC1 7 GO:0002695 negative regulation of leukocyte activation 6/1036 175/18670 0.9278 0.9649 0.852 PTPN22/ANXA1/TBX21/CST7/PGLYRP4/BCR 6 GO:0006956 complement activation 6/1036 175/18670 0.9278 0.9649 0.852 IL1B/C1QBP/C8B/FCN1/CD5L/TRBC1 6 GO:0002067 glandular epithelial cell differentiation 1/1036 46/18670 0.9279 0.9649 0.852 RARA 1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1/1036 46/18670 0.9279 0.9649 0.852 AMIGO2 1 GO:0014075 response to amine 1/1036 46/18670 0.9279 0.9649 0.852 SOD1 1 GO:0030810 positive regulation of nucleotide biosynthetic process 1/1036 46/18670 0.9279 0.9649 0.852 IFNG 1 GO:0032480 negative regulation of type I interferon production 1/1036 46/18670 0.9279 0.9649 0.852 GPATCH3 1 GO:0035088 establishment or maintenance of apical/basal cell polarity 1/1036 46/18670 0.9279 0.9649 0.852 SH3BP1 1 GO:0051339 regulation of lyase activity 1/1036 46/18670 0.9279 0.9649 0.852 TIMP2 1 GO:0061245 establishment or maintenance of bipolar cell polarity 1/1036 46/18670 0.9279 0.9649 0.852 SH3BP1 1 GO:1900373 positive regulation of purine nucleotide biosynthetic process 1/1036 46/18670 0.9279 0.9649 0.852 IFNG 1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1036 46/18670 0.9279 0.9649 0.852 PPP1R16B 1 GO:1904738 vascular associated smooth muscle cell migration 1/1036 46/18670 0.9279 0.9649 0.852 LRP1 1 GO:1904752 regulation of vascular associated smooth muscle cell migration 1/1036 46/18670 0.9279 0.9649 0.852 LRP1 1 GO:0030500 regulation of bone mineralization 2/1036 76/18670 0.9291 0.9659 0.853 ACVR1/BMPR1B 2 GO:0032652 regulation of interleukin-1 production 3/1036 103/18670 0.9302 0.9667 0.8536 IFNG/MALT1/ANXA1 3 GO:0034766 negative regulation of ion transmembrane transport 3/1036 103/18670 0.9302 0.9667 0.8536 CLIC2/NTSR1/YWHAQ 3 GO:0018198 peptidyl-cysteine modification 1/1036 47/18670 0.9319 0.9677 0.8546 ZDHHC4 1 GO:0031952 regulation of protein autophosphorylation 1/1036 47/18670 0.9319 0.9677 0.8546 PPP2R5C 1 GO:0042461 photoreceptor cell development 1/1036 47/18670 0.9319 0.9677 0.8546 TRPM1 1 GO:1901068 guanosine-containing compound metabolic process 1/1036 47/18670 0.9319 0.9677 0.8546 MFN1 1 GO:1903038 negative regulation of leukocyte cell-cell adhesion 4/1036 129/18670 0.9323 0.968 0.8548 PTPN22/ANXA1/TBX21/CCL25 4 GO:0055021 regulation of cardiac muscle tissue growth 2/1036 78/18670 0.9354 0.9692 0.8559 TGFBR2/TGFBR3 2 GO:0072347 response to anesthetic 2/1036 78/18670 0.9354 0.9692 0.8559 ABAT/CXCR4 2 GO:0090398 cellular senescence 2/1036 78/18670 0.9354 0.9692 0.8559 EEF1E1/FBXO5 2 GO:0043266 regulation of potassium ion transport 3/1036 105/18670 0.9357 0.9692 0.8559 ATP1B1/KCNS1/KCNQ1 3 GO:0055017 cardiac muscle tissue growth 3/1036 105/18670 0.9357 0.9692 0.8559 TGFBR2/TGFBR3/HEG1 3 GO:0009311 oligosaccharide metabolic process 1/1036 48/18670 0.9357 0.9692 0.8559 MGAT2 1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 1/1036 48/18670 0.9357 0.9692 0.8559 ACVR1 1 GO:0021517 ventral spinal cord development 1/1036 48/18670 0.9357 0.9692 0.8559 LHX3 1 GO:0055023 positive regulation of cardiac muscle tissue growth 1/1036 48/18670 0.9357 0.9692 0.8559 TGFBR3 1 GO:0072666 establishment of protein localization to vacuole 1/1036 48/18670 0.9357 0.9692 0.8559 VPS37B 1 GO:0101023 vascular endothelial cell proliferation 1/1036 48/18670 0.9357 0.9692 0.8559 ITGA4 1 GO:1905562 regulation of vascular endothelial cell proliferation 1/1036 48/18670 0.9357 0.9692 0.8559 ITGA4 1 GO:1901861 regulation of muscle tissue development 5/1036 155/18670 0.9361 0.9695 0.8561 TGFBR2/FLCN/ERBB3/TGFBR3/HDAC4 5 GO:1902807 negative regulation of cell cycle G1/S phase transition 4/1036 131/18670 0.9372 0.9704 0.8569 PCNA/BRD7/DACT1/BTG2 4 GO:0003300 cardiac muscle hypertrophy 3/1036 106/18670 0.9383 0.971 0.8575 PARP1/ATP2A2/HDAC4 3 GO:0051963 regulation of synapse assembly 3/1036 106/18670 0.9383 0.971 0.8575 AMIGO2/NTN1/ADNP 3 GO:0045652 regulation of megakaryocyte differentiation 2/1036 79/18670 0.9383 0.971 0.8575 PRKCQ/RBM15 2 GO:0030857 negative regulation of epithelial cell differentiation 1/1036 49/18670 0.9393 0.9712 0.8576 IFNG 1 GO:0045010 actin nucleation 1/1036 49/18670 0.9393 0.9712 0.8576 WAS 1 GO:0060042 retina morphogenesis in camera-type eye 1/1036 49/18670 0.9393 0.9712 0.8576 DSCAM 1 GO:1990090 cellular response to nerve growth factor stimulus 1/1036 49/18670 0.9393 0.9712 0.8576 EIF4A3 1 GO:0043271 negative regulation of ion transport 5/1036 157/18670 0.9404 0.9723 0.8586 ABAT/CLIC2/NTSR1/YWHAQ/TRH 5 GO:0048524 positive regulation of viral process 3/1036 107/18670 0.9408 0.9724 0.8587 CCL5/PABPC1/VPS37B 3 GO:0002088 lens development in camera-type eye 2/1036 80/18670 0.9412 0.9726 0.8589 TGFBR2/MAF 2 GO:0072698 protein localization to microtubule cytoskeleton 1/1036 50/18670 0.9426 0.974 0.8601 PCM1 1 GO:1904659 glucose transmembrane transport 3/1036 108/18670 0.9432 0.9744 0.8604 IL1B/TNF/PIK3R1 3 GO:0014855 striated muscle cell proliferation 2/1036 81/18670 0.9439 0.9749 0.8609 TGFBR2/TGFBR3 2 GO:0042692 muscle cell differentiation 15/1036 385/18670 0.945 0.9758 0.8616 RORA/TMEM204/ATP2A2/ACVR1/HIRA/ANKRD17/EHD2/SYNE1/SMARCD3/XBP1/RARA/KCNH1/HDAC4/CD9/ATG5 15 GO:0014897 striated muscle hypertrophy 3/1036 109/18670 0.9455 0.9758 0.8616 PARP1/ATP2A2/HDAC4 3 GO:0043949 regulation of cAMP-mediated signaling 1/1036 51/18670 0.9458 0.9758 0.8616 CRTC3 1 GO:0048260 positive regulation of receptor-mediated endocytosis 1/1036 51/18670 0.9458 0.9758 0.8616 LDLRAP1 1 GO:0048641 regulation of skeletal muscle tissue development 1/1036 51/18670 0.9458 0.9758 0.8616 HDAC4 1 GO:2001258 negative regulation of cation channel activity 1/1036 51/18670 0.9458 0.9758 0.8616 CLIC2 1 GO:0071158 positive regulation of cell cycle arrest 2/1036 82/18670 0.9464 0.976 0.8619 PCNA/BTG2 2 GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2/1036 82/18670 0.9464 0.976 0.8619 ANXA1/PIK3C2A 2 GO:0030514 negative regulation of BMP signaling pathway 1/1036 52/18670 0.9488 0.9778 0.8635 HTRA1 1 GO:0060421 positive regulation of heart growth 1/1036 52/18670 0.9488 0.9778 0.8635 TGFBR3 1 GO:1990089 response to nerve growth factor 1/1036 52/18670 0.9488 0.9778 0.8635 EIF4A3 1 GO:0048145 regulation of fibroblast proliferation 2/1036 83/18670 0.9489 0.9778 0.8635 MYC/NDUFS4 2 GO:0014896 muscle hypertrophy 3/1036 111/18670 0.9499 0.9781 0.8637 PARP1/ATP2A2/HDAC4 3 GO:0006910 phagocytosis, recognition 2/1036 84/18670 0.9513 0.9781 0.8637 FCN1/TRBC1 2 GO:0048144 fibroblast proliferation 2/1036 84/18670 0.9513 0.9781 0.8637 MYC/NDUFS4 2 GO:0051453 regulation of intracellular pH 2/1036 84/18670 0.9513 0.9781 0.8637 CA7/SLAMF8 2 GO:0060420 regulation of heart growth 2/1036 84/18670 0.9513 0.9781 0.8637 TGFBR2/TGFBR3 2 GO:0000186 activation of MAPKK activity 1/1036 53/18670 0.9517 0.9781 0.8637 MAPK3 1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 1/1036 53/18670 0.9517 0.9781 0.8637 PPP1R16B 1 GO:0045661 regulation of myoblast differentiation 1/1036 53/18670 0.9517 0.9781 0.8637 TNF 1 GO:0050702 interleukin-1 beta secretion 1/1036 53/18670 0.9517 0.9781 0.8637 TLR6 1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 1/1036 53/18670 0.9517 0.9781 0.8637 CBLB 1 GO:0060563 neuroepithelial cell differentiation 1/1036 53/18670 0.9517 0.9781 0.8637 SOD1 1 GO:0007033 vacuole organization 5/1036 163/18670 0.9518 0.9781 0.8637 ATG14/SCFD1/TMEM106B/ATG5/FEZ1 5 GO:0008645 hexose transmembrane transport 3/1036 112/18670 0.9519 0.9781 0.8637 IL1B/TNF/PIK3R1 3 GO:0050868 negative regulation of T cell activation 3/1036 112/18670 0.9519 0.9781 0.8637 PTPN22/ANXA1/TBX21 3 GO:0060419 heart growth 3/1036 112/18670 0.9519 0.9781 0.8637 TGFBR2/TGFBR3/HEG1 3 GO:1904705 regulation of vascular smooth muscle cell proliferation 2/1036 85/18670 0.9535 0.9794 0.8648 LDLRAP1/TNF 2 GO:1990874 vascular smooth muscle cell proliferation 2/1036 85/18670 0.9535 0.9794 0.8648 LDLRAP1/TNF 2 GO:0046620 regulation of organ growth 3/1036 113/18670 0.9539 0.9796 0.865 TGFBR2/TGFBR3/SOD1 3 GO:0021515 cell differentiation in spinal cord 1/1036 54/18670 0.9544 0.9797 0.8651 LHX3 1 GO:0045747 positive regulation of Notch signaling pathway 1/1036 54/18670 0.9544 0.9797 0.8651 POGLUT1 1 GO:0015749 monosaccharide transmembrane transport 3/1036 114/18670 0.9558 0.9806 0.8659 IL1B/TNF/PIK3R1 3 GO:0030282 bone mineralization 3/1036 114/18670 0.9558 0.9806 0.8659 ACVR1/ASGR2/BMPR1B 3 GO:0034968 histone lysine methylation 3/1036 114/18670 0.9558 0.9806 0.8659 AUTS2/CTR9/ATRX 3 GO:0042220 response to cocaine 1/1036 55/18670 0.9569 0.9812 0.8664 ABAT 1 GO:0044380 protein localization to cytoskeleton 1/1036 55/18670 0.9569 0.9812 0.8664 PCM1 1 GO:0097120 receptor localization to synapse 1/1036 55/18670 0.9569 0.9812 0.8664 DBN1 1 GO:0010927 cellular component assembly involved in morphogenesis 3/1036 115/18670 0.9576 0.9814 0.8667 CLASP1/CD9/PLA2G3 3 GO:0045844 positive regulation of striated muscle tissue development 2/1036 87/18670 0.9578 0.9814 0.8667 ERBB3/TGFBR3 2 GO:0048636 positive regulation of muscle organ development 2/1036 87/18670 0.9578 0.9814 0.8667 ERBB3/TGFBR3 2 GO:0035051 cardiocyte differentiation 5/1036 167/18670 0.9583 0.9818 0.867 ACVR1/TGFBR3/RARA/MAPK3/ATG5 5 GO:0022029 telencephalon cell migration 1/1036 56/18670 0.9593 0.9822 0.8673 CXCR4 1 GO:0048488 synaptic vesicle endocytosis 1/1036 56/18670 0.9593 0.9822 0.8673 DNM1L 1 GO:0140238 presynaptic endocytosis 1/1036 56/18670 0.9593 0.9822 0.8673 DNM1L 1 GO:0034219 carbohydrate transmembrane transport 3/1036 116/18670 0.9594 0.9822 0.8673 IL1B/TNF/PIK3R1 3 GO:1901863 positive regulation of muscle tissue development 2/1036 88/18670 0.9597 0.9822 0.8673 ERBB3/TGFBR3 2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 5/1036 168/18670 0.9598 0.9822 0.8673 AMIGO2/PLXNB2/PCDHB13/DSCAM/PCDHB6 5 GO:0071804 cellular potassium ion transport 7/1036 217/18670 0.9602 0.9823 0.8674 SLC12A5/ATP1B1/KCNH1/KCNC3/KCNS1/KCNQ1/SLC1A3 7 GO:0071805 potassium ion transmembrane transport 7/1036 217/18670 0.9602 0.9823 0.8674 SLC12A5/ATP1B1/KCNH1/KCNC3/KCNS1/KCNQ1/SLC1A3 7 GO:0051153 regulation of striated muscle cell differentiation 3/1036 117/18670 0.9611 0.9829 0.8679 EHD2/XBP1/HDAC4 3 GO:0010665 regulation of cardiac muscle cell apoptotic process 1/1036 57/18670 0.9616 0.9829 0.8679 HSPB6 1 GO:0045143 homologous chromosome segregation 1/1036 57/18670 0.9616 0.9829 0.8679 TERF1 1 GO:2000272 negative regulation of signaling receptor activity 1/1036 57/18670 0.9616 0.9829 0.8679 CBLB 1 GO:0032651 regulation of interleukin-1 beta production 2/1036 90/18670 0.9634 0.9842 0.8691 IFNG/MALT1 2 GO:0045132 meiotic chromosome segregation 2/1036 90/18670 0.9634 0.9842 0.8691 TERF1/SMC2 2 GO:0046849 bone remodeling 2/1036 90/18670 0.9634 0.9842 0.8691 CD38/IL6 2 GO:0030837 negative regulation of actin filament polymerization 1/1036 58/18670 0.9637 0.9843 0.8692 ADD3 1 GO:0009913 epidermal cell differentiation 13/1036 358/18670 0.9639 0.9844 0.8692 PRKCH/CAPN1/ZFP36/KRT9/ANXA1/BCL11B/NCOA3/TGM3/AKR1C3/SOD1/KLK13/KRT76/BCR 13 GO:0051250 negative regulation of lymphocyte activation 4/1036 146/18670 0.9647 0.985 0.8698 PTPN22/ANXA1/TBX21/PGLYRP4 4 GO:1904063 negative regulation of cation transmembrane transport 2/1036 91/18670 0.9651 0.985 0.8698 CLIC2/NTSR1 2 GO:0010656 negative regulation of muscle cell apoptotic process 1/1036 59/18670 0.9657 0.985 0.8698 HSPB6 1 GO:0010662 regulation of striated muscle cell apoptotic process 1/1036 59/18670 0.9657 0.985 0.8698 HSPB6 1 GO:0021885 forebrain cell migration 1/1036 59/18670 0.9657 0.985 0.8698 CXCR4 1 GO:0045843 negative regulation of striated muscle tissue development 1/1036 59/18670 0.9657 0.985 0.8698 TGFBR2 1 GO:0006342 chromatin silencing 3/1036 120/18670 0.9658 0.985 0.8698 HAT1/HIRA/SMARCA5 3 GO:0010659 cardiac muscle cell apoptotic process 1/1036 60/18670 0.9676 0.9863 0.871 HSPB6 1 GO:0048635 negative regulation of muscle organ development 1/1036 60/18670 0.9676 0.9863 0.871 TGFBR2 1 GO:0046488 phosphatidylinositol metabolic process 5/1036 174/18670 0.9677 0.9863 0.871 CHRM5/PIK3CA/PIK3C2A/PGAP1/PIK3R1 5 GO:0007040 lysosome organization 1/1036 61/18670 0.9694 0.9874 0.8719 TMEM106B 1 GO:0042733 embryonic digit morphogenesis 1/1036 61/18670 0.9694 0.9874 0.8719 ZBTB16 1 GO:0050701 interleukin-1 secretion 1/1036 61/18670 0.9694 0.9874 0.8719 TLR6 1 GO:0080171 lytic vacuole organization 1/1036 61/18670 0.9694 0.9874 0.8719 TMEM106B 1 GO:0007517 muscle organ development 15/1036 410/18670 0.9703 0.9879 0.8723 ARID5B/TGFBR2/BTG2/ITGA7/TNNI1/ERBB3/TGFBR3/ATF3/XBP1/LIF/HDAC4/FHL3/HEG1/FZD2/FXR1 15 GO:0051495 positive regulation of cytoskeleton organization 7/1036 226/18670 0.9704 0.9879 0.8723 NCK1/WAS/CCL11/CLASP1/PFDN2/HAX1/TERF1 7 GO:0010658 striated muscle cell apoptotic process 1/1036 62/18670 0.9711 0.9879 0.8723 HSPB6 1 GO:0032835 glomerulus development 1/1036 62/18670 0.9711 0.9879 0.8723 SULF1 1 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 1/1036 62/18670 0.9711 0.9879 0.8723 ACVR1 1 GO:0042100 B cell proliferation 2/1036 95/18670 0.9712 0.9879 0.8723 CD38/GPR183 2 GO:0055006 cardiac cell development 2/1036 95/18670 0.9712 0.9879 0.8723 TGFBR3/ATG5 2 GO:0016202 regulation of striated muscle tissue development 4/1036 152/18670 0.9722 0.9883 0.8727 TGFBR2/ERBB3/TGFBR3/HDAC4 4 GO:0030902 hindbrain development 4/1036 152/18670 0.9722 0.9883 0.8727 ABAT/RORA/HERC1/CD3E 4 GO:0030326 embryonic limb morphogenesis 3/1036 125/18670 0.9724 0.9883 0.8727 GNAS/RECK/ZBTB16 3 GO:0035113 embryonic appendage morphogenesis 3/1036 125/18670 0.9724 0.9883 0.8727 GNAS/RECK/ZBTB16 3 GO:0030219 megakaryocyte differentiation 2/1036 96/18670 0.9726 0.9883 0.8727 PRKCQ/RBM15 2 GO:0046622 positive regulation of organ growth 1/1036 63/18670 0.9728 0.9883 0.8727 TGFBR3 1 GO:1902905 positive regulation of supramolecular fiber organization 6/1036 204/18670 0.9729 0.9883 0.8727 NCK1/WAS/CCL11/CLASP1/COLGALT1/TERF1 6 GO:0043534 blood vessel endothelial cell migration 5/1036 180/18670 0.9742 0.9893 0.8736 ANXA1/EMP2/PIK3C2A/SH3BP1/FGF18 5 GO:0051147 regulation of muscle cell differentiation 5/1036 181/18670 0.9751 0.99 0.8742 ANKRD17/EHD2/SMARCD3/XBP1/HDAC4 5 GO:0002042 cell migration involved in sprouting angiogenesis 2/1036 98/18670 0.9751 0.99 0.8742 ANXA1/PIK3C2A 2 GO:0072665 protein localization to vacuole 1/1036 65/18670 0.9757 0.9902 0.8744 VPS37B 1 GO:0010595 positive regulation of endothelial cell migration 3/1036 128/18670 0.9758 0.9902 0.8744 ANXA1/PIK3C2A/FGF18 3 GO:0043535 regulation of blood vessel endothelial cell migration 4/1036 156/18670 0.9763 0.9902 0.8744 ANXA1/PIK3C2A/SH3BP1/FGF18 4 GO:0048634 regulation of muscle organ development 4/1036 156/18670 0.9763 0.9902 0.8744 TGFBR2/ERBB3/TGFBR3/HDAC4 4 GO:0010631 epithelial cell migration 12/1036 351/18670 0.9765 0.9902 0.8744 IFNG/TGFBR2/LGALS8/CAPN7/ANXA1/PRKX/EMP2/PIK3CA/PIK3C2A/CLASP1/SH3BP1/FGF18 12 GO:0018022 peptidyl-lysine methylation 3/1036 129/18670 0.9768 0.9902 0.8744 AUTS2/CTR9/ATRX 3 GO:0002040 sprouting angiogenesis 5/1036 183/18670 0.9769 0.9902 0.8744 PPP1R16B/RECK/ANXA1/PARVA/PIK3C2A 5 GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 1/1036 66/18670 0.9771 0.9902 0.8744 AP2B1 1 GO:0060840 artery development 2/1036 100/18670 0.9774 0.9902 0.8744 LRP1/AP2B1 2 GO:0061640 cytoskeleton-dependent cytokinesis 2/1036 100/18670 0.9774 0.9902 0.8744 RASA1/CKAP2 2 GO:2001023 regulation of response to drug 2/1036 100/18670 0.9774 0.9902 0.8744 ABAT/PDE8A 2 GO:0048747 muscle fiber development 1/1036 67/18670 0.9783 0.9908 0.8749 HDAC4 1 GO:0090132 epithelium migration 12/1036 354/18670 0.9784 0.9908 0.8749 IFNG/TGFBR2/LGALS8/CAPN7/ANXA1/PRKX/EMP2/PIK3CA/PIK3C2A/CLASP1/SH3BP1/FGF18 12 GO:0035924 cellular response to vascular endothelial growth factor stimulus 1/1036 68/18670 0.9795 0.9916 0.8756 ANXA1 1 GO:0045806 negative regulation of endocytosis 1/1036 68/18670 0.9795 0.9916 0.8756 ATG5 1 GO:0055007 cardiac muscle cell differentiation 3/1036 132/18670 0.9797 0.9916 0.8756 ACVR1/RARA/ATG5 3 GO:0018958 phenol-containing compound metabolic process 2/1036 103/18670 0.9805 0.992 0.876 ABAT/AKR1B1 2 GO:0048259 regulation of receptor-mediated endocytosis 2/1036 103/18670 0.9805 0.992 0.876 LDLRAP1/CD2AP 2 GO:0036465 synaptic vesicle recycling 1/1036 69/18670 0.9807 0.992 0.876 DNM1L 1 GO:0006813 potassium ion transport 7/1036 240/18670 0.9816 0.9924 0.8763 SLC12A5/ATP1B1/KCNH1/KCNC3/KCNS1/KCNQ1/SLC1A3 7 GO:0060395 SMAD protein signal transduction 1/1036 70/18670 0.9818 0.9924 0.8763 PARP1 1 GO:0072091 regulation of stem cell proliferation 1/1036 70/18670 0.9818 0.9924 0.8763 SMARCD3 1 GO:0090130 tissue migration 12/1036 360/18670 0.9818 0.9924 0.8763 IFNG/TGFBR2/LGALS8/CAPN7/ANXA1/PRKX/EMP2/PIK3CA/PIK3C2A/CLASP1/SH3BP1/FGF18 12 GO:0043010 camera-type eye development 10/1036 314/18670 0.9823 0.9925 0.8764 FKBP8/SOS1/TGFBR2/BMPR1B/SMARCD3/BCL11B/RARA/HMGN1/DSCAM/MAF 10 GO:0008593 regulation of Notch signaling pathway 2/1036 105/18670 0.9823 0.9925 0.8764 POGLUT1/ZBTB7A 2 GO:0071479 cellular response to ionizing radiation 1/1036 71/18670 0.9828 0.9925 0.8764 ATR 1 GO:0060537 muscle tissue development 14/1036 408/18670 0.9828 0.9925 0.8764 TGFBR2/FLCN/POGLUT1/BTG2/ACVR1/NDUFV2/TNNI1/ERBB3/TGFBR3/ATF3/RARA/HDAC4/HEG1/ATG5 14 GO:0010632 regulation of epithelial cell migration 9/1036 291/18670 0.9828 0.9925 0.8764 IFNG/TGFBR2/CAPN7/ANXA1/EMP2/PIK3C2A/CLASP1/SH3BP1/FGF18 9 GO:0021510 spinal cord development 2/1036 106/18670 0.9832 0.9925 0.8764 DAAM2/LHX3 2 GO:0007601 visual perception 6/1036 218/18670 0.9836 0.9925 0.8764 CRYZ/BEST1/GLRA1/KIFC3/ABLIM1/TRPM1 6 GO:0051155 positive regulation of striated muscle cell differentiation 1/1036 72/18670 0.9837 0.9925 0.8764 EHD2 1 GO:0006958 complement activation, classical pathway 3/1036 137/18670 0.9837 0.9925 0.8764 C1QBP/C8B/TRBC1 3 GO:1903670 regulation of sprouting angiogenesis 3/1036 137/18670 0.9837 0.9925 0.8764 PPP1R16B/ANXA1/PIK3C2A 3 GO:0033555 multicellular organismal response to stress 1/1036 73/18670 0.9846 0.993 0.8769 VDAC3 1 GO:0071156 regulation of cell cycle arrest 2/1036 108/18670 0.9848 0.993 0.8769 PCNA/BTG2 2 GO:0099504 synaptic vesicle cycle 5/1036 194/18670 0.9849 0.993 0.8769 ATP2A2/P2RX1/SV2A/DNM1L/CHRM2 5 GO:0051149 positive regulation of muscle cell differentiation 2/1036 109/18670 0.9855 0.9935 0.8773 EHD2/SMARCD3 2 GO:0050953 sensory perception of light stimulus 6/1036 222/18670 0.9859 0.9937 0.8775 CRYZ/BEST1/GLRA1/KIFC3/ABLIM1/TRPM1 6 GO:0043542 endothelial cell migration 8/1036 273/18670 0.9861 0.9937 0.8775 LGALS8/ANXA1/PRKX/EMP2/PIK3CA/PIK3C2A/SH3BP1/FGF18 8 GO:0010611 regulation of cardiac muscle hypertrophy 1/1036 75/18670 0.9863 0.9937 0.8775 PARP1 1 GO:0048844 artery morphogenesis 1/1036 76/18670 0.9871 0.9943 0.878 LRP1 1 GO:0002065 columnar/cuboidal epithelial cell differentiation 2/1036 112/18670 0.9875 0.9944 0.8781 RARA/SOD1 2 GO:0048593 camera-type eye morphogenesis 2/1036 112/18670 0.9875 0.9944 0.8781 HMGN1/DSCAM 2 GO:0060041 retina development in camera-type eye 3/1036 144/18670 0.9881 0.9948 0.8784 BMPR1B/SMARCD3/DSCAM 3 GO:0014743 regulation of muscle hypertrophy 1/1036 78/18670 0.9885 0.9948 0.8784 PARP1 1 GO:0032413 negative regulation of ion transmembrane transporter activity 1/1036 78/18670 0.9885 0.9948 0.8784 CLIC2 1 GO:0007032 endosome organization 1/1036 79/18670 0.9891 0.9953 0.8788 VPS37B 1 GO:0035265 organ growth 5/1036 204/18670 0.9898 0.9957 0.8793 TGFBR2/TGFBR3/RARA/HEG1/SOD1 5 GO:0048592 eye morphogenesis 3/1036 149/18670 0.9905 0.9963 0.8798 HMGN1/DSCAM/TRPM1 3 GO:0006911 phagocytosis, engulfment 2/1036 118/18670 0.9907 0.9963 0.8798 SH3BP1/TRBC1 2 GO:0001654 eye development 11/1036 362/18670 0.9917 0.997 0.8804 FKBP8/SOS1/TGFBR2/BMPR1B/SMARCD3/BCL11B/RARA/HMGN1/DSCAM/TRPM1/MAF 11 GO:0045445 myoblast differentiation 1/1036 84/18670 0.9918 0.997 0.8804 TNF 1 GO:0014706 striated muscle tissue development 12/1036 390/18670 0.9926 0.9974 0.8807 TGFBR2/BTG2/ACVR1/NDUFV2/TNNI1/ERBB3/TGFBR3/ATF3/RARA/HDAC4/HEG1/ATG5 12 GO:0150063 visual system development 11/1036 366/18670 0.9927 0.9974 0.8807 FKBP8/SOS1/TGFBR2/BMPR1B/SMARCD3/BCL11B/RARA/HMGN1/DSCAM/TRPM1/MAF 11 GO:0051146 striated muscle cell differentiation 8/1036 293/18670 0.9931 0.9974 0.8807 ACVR1/EHD2/XBP1/RARA/KCNH1/HDAC4/CD9/ATG5 8 GO:0030317 flagellated sperm motility 1/1036 87/18670 0.9931 0.9974 0.8807 PLA2G3 1 GO:0097722 sperm motility 1/1036 87/18670 0.9931 0.9974 0.8807 PLA2G3 1 GO:0048880 sensory system development 11/1036 371/18670 0.9938 0.9976 0.8809 FKBP8/SOS1/TGFBR2/BMPR1B/SMARCD3/BCL11B/RARA/HMGN1/DSCAM/TRPM1/MAF 11 GO:0032410 negative regulation of transporter activity 1/1036 89/18670 0.9939 0.9976 0.8809 CLIC2 1 GO:0055013 cardiac muscle cell development 1/1036 89/18670 0.9939 0.9976 0.8809 ATG5 1 GO:0099024 plasma membrane invagination 2/1036 127/18670 0.9941 0.9976 0.881 SH3BP1/TRBC1 2 GO:0007519 skeletal muscle tissue development 3/1036 160/18670 0.9943 0.9976 0.881 BTG2/ATF3/HDAC4 3 GO:0035278 miRNA mediated inhibition of translation 1/1036 93/18670 0.9951 0.9978 0.8811 ZFP36 1 GO:0040033 negative regulation of translation, ncRNA-mediated 1/1036 93/18670 0.9951 0.9978 0.8811 ZFP36 1 GO:0045974 regulation of translation, ncRNA-mediated 1/1036 93/18670 0.9951 0.9978 0.8811 ZFP36 1 GO:0031424 keratinization 5/1036 224/18670 0.9954 0.9978 0.8811 CAPN1/KRT9/TGM3/KLK13/KRT76 5 GO:0010324 membrane invagination 2/1036 135/18670 0.9961 0.9978 0.8811 SH3BP1/TRBC1 2 GO:0031032 actomyosin structure organization 4/1036 199/18670 0.9961 0.9978 0.8811 WAS/PTGER4/CLASP1/PIK3R1 4 GO:0060538 skeletal muscle organ development 3/1036 169/18670 0.9962 0.9978 0.8811 BTG2/ATF3/HDAC4 3 GO:0010594 regulation of endothelial cell migration 5/1036 229/18670 0.9963 0.9978 0.8811 ANXA1/EMP2/PIK3C2A/SH3BP1/FGF18 5 GO:0043473 pigmentation 1/1036 98/18670 0.9963 0.9978 0.8811 KRT76 1 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 1/1036 98/18670 0.9963 0.9978 0.8811 XBP1 1 GO:0016525 negative regulation of angiogenesis 3/1036 173/18670 0.9969 0.9982 0.8814 PGK1/SULF1/STAB1 3 GO:2000181 negative regulation of blood vessel morphogenesis 3/1036 175/18670 0.9972 0.9983 0.8815 PGK1/SULF1/STAB1 3 GO:0055001 muscle cell development 3/1036 186/18670 0.9983 0.9991 0.8823 ATP2A2/HDAC4/ATG5 3 GO:1901343 negative regulation of vasculature development 3/1036 187/18670 0.9984 0.9991 0.8823 PGK1/SULF1/STAB1 3 GO:0055002 striated muscle cell development 2/1036 173/18670 0.9994 1 0.883 HDAC4/ATG5 2 GO:0007608 sensory perception of smell 4/1036 454/18670 1 1 0.883 OR10H1/OR1A1/B3GNT2/FZD2 4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell 2/1036 427/18670 1 1 0.883 OR10H1/OR1A1 2 GO:0050907 detection of chemical stimulus involved in sensory perception 2/1036 477/18670 1 1 0.883 OR10H1/OR1A1 2