ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count BP GO:0030198 extracellular matrix organization 70/819 368/18670 7.798e-26 3.055e-22 2.343e-22 COL8A1/BGN/COL5A2/COL3A1/GREM1/KAZALD1/COL16A1/COL1A2/NID2/BMP1/NID1/THBS1/SPARC/CYP1B1/COL11A1/PXDN/EMILIN1/POSTN/RAMP2/COL1A1/ITGA1/SERPINH1/ADAM12/COMP/FMOD/LAMB1/TGFBR1/FOXC1/ELN/COL14A1/ADAM15/ITGB2/HSPG2/P4HA1/HAPLN1/FBN2/FAP/LOX/COL6A3/ITGB3/ITGA3/HAS2/COL7A1/PDGFA/MPV17/COL15A1/LOXL2/FSCN1/GPM6B/COL4A1/DDR2/TGFB2/SULF1/CAPNS1/ADAM19/LAMA1/GAS6/ITGA6/MMP17/TNFRSF11B/FBLN5/TNC/ACAN/ITGA2/SH3PXD2A/PTX3/COL4A2/VCAN/NCAN/ITGB1 70 BP GO:0043062 extracellular structure organization 75/819 422/18670 1.124e-25 3.055e-22 2.343e-22 COL8A1/BGN/COL5A2/COL3A1/GREM1/KAZALD1/COL16A1/COL1A2/NID2/STAM/BMP1/NID1/THBS1/SPARC/CYP1B1/COL11A1/PXDN/EMILIN1/POSTN/ABCG1/RAMP2/COL1A1/ITGA1/SERPINH1/ADAM12/COMP/FMOD/LAMB1/TGFBR1/FOXC1/ELN/COL14A1/ADAM15/ITGB2/HSPG2/P4HA1/HAPLN1/FBN2/FAP/LOX/COL6A3/PLTP/ITGB3/ITGA3/HAS2/COL7A1/PDGFA/MPV17/COL15A1/LOXL2/FSCN1/GPM6B/COL4A1/DDR2/TGFB2/SULF1/CAPNS1/ADAM19/LAMA1/GAS6/ITGA6/MMP17/TSG101/TNFRSF11B/FBLN5/TNC/ACAN/ITGA2/SH3PXD2A/PTX3/COL4A2/VCAN/SDC4/NCAN/ITGB1 75 BP GO:0030199 collagen fibril organization 21/819 54/18670 3.137e-15 5.686e-12 4.361e-12 COL5A2/COL3A1/GREM1/COL1A2/CYP1B1/COL11A1/PXDN/EMILIN1/COL1A1/SERPINH1/COMP/FMOD/TGFBR1/FOXC1/COL14A1/P4HA1/LOX/LOXL2/DDR2/TGFB2/ACAN 21 BP GO:0031589 cell-substrate adhesion 49/819 354/18670 8.962e-13 1.218e-09 9.344e-10 COL8A1/COL3A1/EDIL3/ACTN1/COL16A1/NID2/NID1/THBS1/MYOC/EMILIN1/POSTN/FZD7/COL1A1/ITGA1/ANGPT1/LAMB1/MEGF9/PIK3R1/ADAM15/ITGB2/HSPG2/CIB1/IQGAP1/NRP1/ITGB3/ITGA3/HAS2/PTPRK/GPM6B/ARL2/SORBS3/PIK3CB/THY1/BST1/DDR2/RASA1/ITGB1BP1/JAK2/GAS6/ITGA6/BCL2/FBLN5/ITGA2/PIP5K1A/SDC4/CDKN2A/PRKX/VAMP3/ITGB1 49 BP GO:0001503 ossification 50/819 398/18670 2.018e-11 2.194e-08 1.683e-08 MAPK3/ENPP1/COL5A2/GREM1/KAZALD1/CDH11/SATB2/COL1A2/BMP1/MYOC/SPARC/CHSY1/COL11A1/RRBP1/COL1A1/ISG15/COMP/BMP4/CLIC1/GJA1/FOXC1/PRKD1/ADAR/WWTR1/RASSF2/FBN2/SNAI2/LOX/TFAP2A/HIF1A/CCR1/MRC2/GPM6B/DDR2/TGFB2/PEX7/EXT1/IL6ST/WNT11/ROR2/BCL2/TNC/TCIRG1/ASF1A/FZD1/CAT/VCAN/PHB/PDLIM7/NAB1 50 BP GO:0007160 cell-matrix adhesion 34/819 225/18670 2.741e-10 2.484e-07 1.905e-07 COL3A1/ACTN1/COL16A1/NID2/NID1/THBS1/MYOC/EMILIN1/POSTN/ITGA1/PIK3R1/ADAM15/ITGB2/CIB1/IQGAP1/NRP1/ITGB3/ITGA3/PTPRK/GPM6B/PIK3CB/THY1/BST1/DDR2/RASA1/ITGB1BP1/ITGA6/BCL2/FBLN5/ITGA2/PIP5K1A/SDC4/CDKN2A/ITGB1 34 BP GO:1902903 regulation of supramolecular fiber organization 41/819 352/18670 1.243e-08 9.653e-06 7.403e-06 HIP1R/CRYAB/MYOC/CXCL12/EMILIN1/TGFBR1/PIK3R1/ELN/CDC42EP1/CIB1/TPM1/NRP1/TMOD1/CAPZA2/FKBP4/HAX1/MET/ARPC1B/GSN/TWF2/EPS8/ARL2/SORBS3/MAPRE3/CAV3/ARHGEF15/RASA1/ITGB1BP1/WNT11/CLIP1/LPAR1/MTOR/CAMSAP2/BIN1/SPTBN1/MAP1A/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 41 BP GO:0007229 integrin-mediated signaling pathway 20/819 103/18670 1.824e-08 1.12e-05 8.589e-06 COL3A1/COL16A1/ITGA1/ISG15/PRKD1/ADAM15/ITGB2/PLP1/MYH9/NRP1/ITGB3/ITGA3/THY1/BST1/ITGB1BP1/ITGA6/ITGA2/PTPN11/PHACTR4/ITGB1 20 BP GO:0010810 regulation of cell-substrate adhesion 30/819 215/18670 2.034e-08 1.12e-05 8.589e-06 COL8A1/EDIL3/COL16A1/NID1/THBS1/MYOC/EMILIN1/POSTN/FZD7/COL1A1/PIK3R1/ADAM15/CIB1/IQGAP1/NRP1/ITGA3/HAS2/GPM6B/ARL2/PIK3CB/THY1/BST1/DDR2/RASA1/ITGB1BP1/JAK2/ITGA6/BCL2/SDC4/CDKN2A 30 BP GO:0007015 actin filament organization 44/819 400/18670 2.059e-08 1.12e-05 8.589e-06 ACTN1/HIP1R/MICAL2/MYOC/TPM2/CXCL12/TGFBR1/PIK3R1/ELN/CDC42EP1/DPYSL3/TPM1/NRP1/TMOD1/CAPZA2/HAX1/DIAPH1/MET/CD2AP/ARPC1B/GSN/TWF2/FSCN1/EPS8/SORBS3/CAV3/ARHGEF15/RASA1/ITGB1BP1/JAK2/WNT11/LPAR1/MTOR/BCL2/BIN1/SPTBN1/PAWR/SDC4/EZR/GMFG/RHOBTB2/LMOD1/NCK1/SORBS2 44 BP GO:0090130 tissue migration 41/819 360/18670 2.363e-08 1.168e-05 8.958e-06 GREM1/PRCP/THBS1/SPARC/CYP1B1/PRKCA/GRN/BMP4/ANGPT1/SCG2/TGFBR1/PLXND1/VEGFC/PRKD1/MCC/ITGB2/SASH1/CIB1/MYH9/EPHB4/FAP/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/LOXL2/TGFB2/KLF4/ITGB1BP1/MTOR/ITGA2/NRP2/ACTA2/ENPP2/PTPN11/PKN1/PRKX/ITGB1 41 BP GO:0010631 epithelial cell migration 40/819 351/18670 3.445e-08 1.561e-05 1.197e-05 GREM1/PRCP/THBS1/SPARC/CYP1B1/PRKCA/GRN/BMP4/ANGPT1/SCG2/TGFBR1/PLXND1/VEGFC/PRKD1/MCC/ITGB2/SASH1/CIB1/MYH9/EPHB4/FAP/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/LOXL2/TGFB2/KLF4/ITGB1BP1/MTOR/ITGA2/NRP2/ENPP2/PTPN11/PKN1/PRKX/ITGB1 40 BP GO:0090132 epithelium migration 40/819 354/18670 4.358e-08 1.823e-05 1.398e-05 GREM1/PRCP/THBS1/SPARC/CYP1B1/PRKCA/GRN/BMP4/ANGPT1/SCG2/TGFBR1/PLXND1/VEGFC/PRKD1/MCC/ITGB2/SASH1/CIB1/MYH9/EPHB4/FAP/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/LOXL2/TGFB2/KLF4/ITGB1BP1/MTOR/ITGA2/NRP2/ENPP2/PTPN11/PKN1/PRKX/ITGB1 40 BP GO:2000027 regulation of animal organ morphogenesis 32/819 253/18670 7.409e-08 2.878e-05 2.207e-05 VDR/GREM1/PSMD8/PSMB7/FZD7/MAGED1/BMP4/PTK7/TGFBR1/FOXC1/PSMD1/FZD2/SNAI2/TFAP2A/GPC4/PSMB6/FZD6/TUG1/PDGFA/CAV3/TGFB2/ARRB2/SULF1/WNT11/TNFRSF11B/ROR2/BCL2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 32 BP GO:0001655 urogenital system development 37/819 330/18670 1.703e-07 5.909e-05 4.532e-05 CRLF1/PCSK5/MTSS1/NID1/EPHB2/MAGED1/BMP4/ANGPT1/TGFBR1/FOXC1/WWTR1/IQGAP1/NRP1/FKBP4/TFAP2A/ITGA3/PODXL/HAS2/NUP93/PDGFA/MPV17/CD24/COL4A1/TGFB2/NOTCH3/SULF1/ITGA6/WNT11/MMP17/BCL2/TNC/ACTA2/CAT/CASP9/SOX4/SDC4/PRKX 37 BP GO:0001667 ameboidal-type cell migration 46/819 461/18670 1.851e-07 5.909e-05 4.532e-05 GREM1/PRCP/THBS1/SPARC/CYP1B1/PRKCA/GRN/BMP4/ANGPT1/SCG2/TGFBR1/PLXND1/VEGFC/PRKD1/MCC/ITGB2/SASH1/CIB1/MYH9/EPHB4/FAP/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/LOXL2/DDR2/TGFB2/KLF4/ITGB1BP1/WNT11/MTOR/HTR2B/ITGA2/PIP5K1A/NRP2/ENPP2/PTPN11/SDC4/PHACTR4/PKN1/PRKX/ITGB1 46 BP GO:0032970 regulation of actin filament-based process 41/819 388/18670 1.884e-07 5.909e-05 4.532e-05 HIP1R/MYOC/CXCL12/ATP2A2/TGFBR1/PIK3R1/ELN/CDC42EP1/TPM1/MYH9/NRP1/TMOD1/CAPZA2/PDE4B/HAX1/MET/CD2AP/ARPC1B/GSN/TWF2/PDGFA/FSCN1/EPS8/GPM6B/SORBS3/CAV3/BST1/ARHGEF15/RASA1/ITGB1BP1/WNT11/LPAR1/MTOR/CACNA1C/BIN1/SPTBN1/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 41 BP GO:0045785 positive regulation of cell adhesion 42/819 403/18670 1.956e-07 5.909e-05 4.532e-05 COL8A1/EDIL3/COL16A1/CD55/NID1/MYOC/PRKCA/CXCL12/EMILIN1/ANGPT1/PIK3R1/CD70/IL12A/TGM2/ITGB2/MYO10/CIB1/TNFRSF14/TPM1/IQGAP1/NRP1/ITGA3/PODXL/HAS2/CD24/ARL2/THY1/TGFB2/ITGB1BP1/ADAM19/JAK2/ITGA6/SOCS5/IL6ST/IL4R/BAD/ITGA2/PTPN11/SDC4/NCK1/HLX/HLA-DPB1 42 BP GO:0072001 renal system development 34/819 293/18670 2.387e-07 6.632e-05 5.086e-05 CRLF1/PCSK5/MTSS1/NID1/MAGED1/BMP4/ANGPT1/TGFBR1/FOXC1/WWTR1/IQGAP1/NRP1/TFAP2A/ITGA3/PODXL/HAS2/NUP93/PDGFA/MPV17/CD24/COL4A1/TGFB2/NOTCH3/SULF1/ITGA6/WNT11/MMP17/BCL2/ACTA2/CAT/CASP9/SOX4/SDC4/PRKX 34 BP GO:0018108 peptidyl-tyrosine phosphorylation 39/819 363/18670 2.439e-07 6.632e-05 5.086e-05 MAPK3/GREM1/CRLF1/THBS4/EPHB2/ANGPT1/NTRK2/IL12A/ITGB2/TNFRSF14/GHR/IQGAP1/EPHB4/NRP1/HAX1/MET/ITGB3/EFEMP1/PDGFA/CD24/THY1/BST1/DDR2/STAT3/ARRB2/JAK2/GAS6/SOCS5/IL6ST/SOCS3/MTOR/TSG101/ROR2/MAP2K4/PPP2R1A/EPHB6/ENPP2/PTPN11/DYRK1B 39 BP GO:0070482 response to oxygen levels 41/819 394/18670 2.847e-07 7.371e-05 5.653e-05 CRYAB/STC2/THBS1/PSMD8/PIN1/PSMB7/CXCL12/PDLIM1/POSTN/RAMP2/COL1A1/SOD3/ATP6V0D1/VEGFC/PSMD1/ADAM15/LDHA/TM9SF4/HIF1A/PSMB6/EPAS1/LOXL2/CD24/ATP1B1/TGFB2/UCP2/PDK1/LPAR1/MTOR/BAD/KCNMB1/BCL2/EDNRA/ITGA2/CAT/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 41 BP GO:0018212 peptidyl-tyrosine modification 39/819 366/18670 3.02e-07 7.464e-05 5.724e-05 MAPK3/GREM1/CRLF1/THBS4/EPHB2/ANGPT1/NTRK2/IL12A/ITGB2/TNFRSF14/GHR/IQGAP1/EPHB4/NRP1/HAX1/MET/ITGB3/EFEMP1/PDGFA/CD24/THY1/BST1/DDR2/STAT3/ARRB2/JAK2/GAS6/SOCS5/IL6ST/SOCS3/MTOR/TSG101/ROR2/MAP2K4/PPP2R1A/EPHB6/ENPP2/PTPN11/DYRK1B 39 BP GO:0032835 glomerulus development 14/819 62/18670 3.576e-07 8.454e-05 6.483e-05 MTSS1/NID1/BMP4/ANGPT1/FOXC1/WWTR1/IQGAP1/PODXL/MPV17/CD24/NOTCH3/SULF1/BCL2/ACTA2 14 BP GO:0019058 viral life cycle 36/819 328/18670 4.212e-07 9.543e-05 7.319e-05 CD55/PCSK5/OAS1/RAD23A/ISG15/ADARB1/ADAR/SLC1A5/TRIM25/TNFRSF14/LAMTOR5/IFIT1/ITGB3/NUP205/GSN/PPIB/NUP93/NUP153/BANF1/OASL/GAS6/RSAD2/APOBEC3C/SEC13/CHMP2A/RAB29/IFI27/TSG101/BCL2/FBXL2/ITGA2/PTX3/MX1/HTATSF1/KPNA3/ITGB1 36 BP GO:0032956 regulation of actin cytoskeleton organization 37/819 343/18670 4.484e-07 9.754e-05 7.481e-05 HIP1R/MYOC/CXCL12/TGFBR1/PIK3R1/ELN/CDC42EP1/TPM1/NRP1/TMOD1/CAPZA2/HAX1/MET/CD2AP/ARPC1B/GSN/TWF2/PDGFA/FSCN1/EPS8/GPM6B/SORBS3/CAV3/BST1/ARHGEF15/RASA1/ITGB1BP1/WNT11/LPAR1/MTOR/BIN1/SPTBN1/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 37 BP GO:0110053 regulation of actin filament organization 31/819 261/18670 4.848e-07 0.0001014 7.776e-05 HIP1R/MYOC/CXCL12/TGFBR1/PIK3R1/ELN/CDC42EP1/TPM1/NRP1/TMOD1/CAPZA2/HAX1/MET/ARPC1B/GSN/TWF2/EPS8/SORBS3/ARHGEF15/RASA1/ITGB1BP1/WNT11/LPAR1/MTOR/BIN1/SPTBN1/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 31 BP GO:0001666 response to hypoxia 38/819 359/18670 5.061e-07 0.0001019 7.817e-05 CRYAB/STC2/THBS1/PSMD8/PIN1/PSMB7/CXCL12/PDLIM1/POSTN/RAMP2/SOD3/VEGFC/PSMD1/ADAM15/LDHA/TM9SF4/HIF1A/PSMB6/EPAS1/LOXL2/CD24/ATP1B1/TGFB2/UCP2/PDK1/MTOR/BAD/KCNMB1/BCL2/EDNRA/ITGA2/CAT/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 38 BP GO:0050673 epithelial cell proliferation 43/819 434/18670 5.643e-07 0.0001096 8.404e-05 COL8A1/VDR/THBS4/MTSS1/THBS1/SPARC/KDM5B/TCF7L2/PRKCA/CXCL12/FZD7/MAGED1/GRN/BMP4/LAMB1/GJA1/SCG2/TGFBR1/VEGFC/PRKD1/NUPR1/MCC/SNAI2/FAP/NRP1/CCR3/HIF1A/ITGB3/HAS2/PTPRK/LOXL2/PIK3CB/STAT3/TGFB2/ITGB1BP1/SULF1/HMGN1/ZFP36/MTOR/BAD/HTR2B/NRP2/PRKX 43 BP GO:0043434 response to peptide hormone 43/819 436/18670 6.389e-07 0.0001184 9.08e-05 ENPP1/ATP6V0E2/RARRES2/PTPRA/STC2/SPARC/ATP6V0A1/RANGAP1/ADCY8/CXCL12/COL1A1/TBC1D4/ATP6V0D1/ATP6V1E1/GJA1/PIK3R1/ADCY7/IGFBP1/KAT2B/QDPR/GHR/ATP6V0C/INHBB/IQGAP1/ATP6V1H/HADH/MYO5A/PIK3R2/GRB10/STAT3/JAK2/PRKCB/SOCS3/RAB8A/MTOR/TCIRG1/ATP6V1D/CAT/PTPN11/PDK2/FOXO3/GNRHR/NCK1 43 BP GO:0035567 non-canonical Wnt signaling pathway 22/819 150/18670 6.532e-07 0.0001184 9.08e-05 SFRP4/MYOC/PSMD8/TCF7L2/PSMB7/FZD7/PTK7/PSMD1/FZD2/TNRC6B/GPC4/PSMB6/FZD6/ARRB2/WNT11/ROR2/PLCB1/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 22 BP GO:0008286 insulin receptor signaling pathway 21/819 141/18670 9.027e-07 0.0001584 0.0001214 ENPP1/ATP6V0E2/RARRES2/PTPRA/ATP6V0A1/ATP6V0D1/ATP6V1E1/PIK3R1/IGFBP1/ATP6V0C/ATP6V1H/PIK3R2/GRB10/PRKCB/SOCS3/TCIRG1/ATP6V1D/PTPN11/PDK2/FOXO3/NCK1 21 BP GO:0051258 protein polymerization 32/819 283/18670 9.568e-07 0.0001615 0.0001238 HIP1R/ELN/CDC42EP1/TMOD1/CAPZA2/FKBP4/HAX1/DIAPH1/MET/ARPC1B/GSN/TWF2/EPS8/ARL2/MAPRE3/CAV3/RASA1/GPX4/JAK2/CHMP2A/CLIP1/MTOR/CAMSAP2/BIN1/SPTBN1/CKAP5/MX1/MX2/GMFG/RHOBTB2/LMOD1/NCK1 32 BP GO:0090090 negative regulation of canonical Wnt signaling pathway 24/819 178/18670 9.857e-07 0.0001615 0.0001238 SFRP4/GREM1/SIAH2/PSMD8/TCF7L2/PSMB7/BICC1/IGFBP1/MCC/PSMD1/WWTR1/SNAI2/PSMB6/FZD6/IGFBP6/RAPGEF1/TLE4/WNT11/ROR2/FZD1/PSMD3/FOXO3/PSMD2/PSMB8 24 BP GO:0001952 regulation of cell-matrix adhesion 19/819 119/18670 1.01e-06 0.0001615 0.0001238 COL16A1/THBS1/MYOC/POSTN/PIK3R1/ADAM15/CIB1/IQGAP1/NRP1/GPM6B/PIK3CB/THY1/BST1/DDR2/RASA1/ITGB1BP1/BCL2/SDC4/CDKN2A 19 BP GO:0036293 response to decreased oxygen levels 38/819 370/18670 1.071e-06 0.0001658 0.0001272 CRYAB/STC2/THBS1/PSMD8/PIN1/PSMB7/CXCL12/PDLIM1/POSTN/RAMP2/SOD3/VEGFC/PSMD1/ADAM15/LDHA/TM9SF4/HIF1A/PSMB6/EPAS1/LOXL2/CD24/ATP1B1/TGFB2/UCP2/PDK1/MTOR/BAD/KCNMB1/BCL2/EDNRA/ITGA2/CAT/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 38 BP GO:0046677 response to antibiotic 35/819 327/18670 1.098e-06 0.0001658 0.0001272 PYCR1/CRYAB/SPARC/KDM5B/OXCT1/CYP1B1/ADCY8/COL1A1/TXN/ADCY7/HSPA5/BCL2L1/LDHA/MAP3K5/MET/GSN/TRAP1/UROS/EPS8/STAT3/KLF4/RGS2/JAK2/GRIN2B/SIGMAR1/BAD/KCNMB1/BCL2/TNC/CAT/TRPC6/PAWR/CASP9/FOXO3/GRIN2A 35 BP GO:1905330 regulation of morphogenesis of an epithelium 24/819 180/18670 1.209e-06 0.0001776 0.0001362 PSMD8/PSMB7/FZD7/MAGED1/BMP4/PTK7/PSMD1/FZD2/SNAI2/GPC4/PSMB6/FZD6/PDGFA/CAV3/ARRB2/SULF1/WNT11/MTOR/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 24 BP GO:0043542 endothelial cell migration 31/819 273/18670 1.288e-06 0.0001844 0.0001414 GREM1/PRCP/THBS1/SPARC/CYP1B1/PRKCA/GRN/BMP4/ANGPT1/SCG2/TGFBR1/PLXND1/VEGFC/PRKD1/ITGB2/SASH1/CIB1/MYH9/EPHB4/FAP/NRP1/HIF1A/MET/ITGB3/ANXA3/LOXL2/KLF4/ITGB1BP1/NRP2/PRKX/ITGB1 31 BP GO:0006024 glycosaminoglycan biosynthetic process 18/819 110/18670 1.34e-06 0.0001868 0.0001433 BGN/SLC35D2/NDST1/CHST7/CEMIP/CHSY1/FMOD/ANGPT1/B4GALT2/HSPG2/GPC4/HAS2/CHST2/EXT1/ACAN/VCAN/SDC4/NCAN 18 BP GO:0003012 muscle system process 44/819 465/18670 1.457e-06 0.0001941 0.0001488 GSTO1/CLIC2/CRYAB/MYOC/TPM2/PIN1/PRKCA/ATP2A2/ITGA1/COMP/GJA1/GJC1/KCND3/TPM1/NDUFS6/SNTA1/MYLK/TMOD1/PDE4B/SMTN/GSN/SORBS3/CAV3/ATP1B1/KLF4/SULF1/RGS2/STAC/IL6ST/GPD1L/MTOR/CKMT2/SGCA/MAP2K4/CACNA1C/HTR2B/CNN1/EDNRA/ITGA2/BIN1/ACTA2/FOXO3/LMOD1/SORBS2 44 BP GO:0019079 viral genome replication 19/819 122/18670 1.489e-06 0.0001941 0.0001488 OAS1/RAD23A/ISG15/ADARB1/ADAR/LAMTOR5/IFIT1/PPIB/BANF1/OASL/GAS6/RSAD2/APOBEC3C/RAB29/IFI27/BCL2/FBXL2/MX1/HTATSF1 19 BP GO:0050792 regulation of viral process 26/819 208/18670 1.533e-06 0.0001941 0.0001488 POLR2L/POLR2E/OAS1/RAD23A/ISG15/ADARB1/ADAR/TRIM25/MDFIC/IFIT1/GSN/PPIB/BANF1/OASL/SUPT4H1/RSAD2/ZFP36/APOBEC3C/CHMP2A/CHD1/IFI27/TSG101/BCL2/FBXL2/PTX3/MX1 26 BP GO:1904019 epithelial cell apoptotic process 18/819 111/18670 1.535e-06 0.0001941 0.0001488 SFRP4/THBS1/TCF7L2/RAMP2/ANGPT1/SCG2/NUPR1/BCL2L1/MAP3K5/GSN/ARRB2/JAK2/GAS6/ZFP36/MTOR/BAD/KRT18/FOXO3 18 BP GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 27/819 222/18670 1.659e-06 0.000205 0.0001572 POLR2L/POLR2E/OAS1/RAD23A/ISG15/ADARB1/ADAR/TRIM25/MDFIC/IFIT1/GSN/PPIB/BANF1/OASL/SUPT4H1/RSAD2/ZFP36/APOBEC3C/CHMP2A/CHD1/IFI27/TSG101/BAD/BCL2/FBXL2/PTX3/MX1 27 BP GO:0010634 positive regulation of epithelial cell migration 23/819 171/18670 1.722e-06 0.0002065 0.0001583 THBS1/SPARC/PRKCA/GRN/BMP4/ANGPT1/VEGFC/PRKD1/SASH1/CIB1/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/TGFB2/ITGB1BP1/MTOR/ITGA2/NRP2/ENPP2 23 BP GO:0046034 ATP metabolic process 33/819 305/18670 1.746e-06 0.0002065 0.0001583 ENPP1/NADK/CTNS/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 33 BP GO:0001822 kidney development 31/819 278/18670 1.897e-06 0.0002195 0.0001684 CRLF1/PCSK5/MTSS1/NID1/MAGED1/BMP4/ANGPT1/TGFBR1/FOXC1/WWTR1/IQGAP1/NRP1/TFAP2A/ITGA3/PODXL/HAS2/PDGFA/MPV17/CD24/TGFB2/NOTCH3/SULF1/WNT11/MMP17/BCL2/ACTA2/CAT/CASP9/SOX4/SDC4/PRKX 31 BP GO:0001649 osteoblast differentiation 27/819 225/18670 2.152e-06 0.0002438 0.000187 GREM1/SATB2/MYOC/RRBP1/COL1A1/BMP4/CLIC1/GJA1/PRKD1/ADAR/WWTR1/RASSF2/FBN2/SNAI2/LOX/MRC2/DDR2/IL6ST/WNT11/TNC/TCIRG1/ASF1A/FZD1/CAT/VCAN/PHB/PDLIM7 27 BP GO:0090382 phagosome maturation 11/819 44/18670 2.199e-06 0.000244 0.0001872 ATP6V0E2/ATP6V0A1/RAB32/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/SPG11/UNC13B/TCIRG1/ATP6V1D 11 BP GO:0006023 aminoglycan biosynthetic process 18/819 115/18670 2.597e-06 0.0002825 0.0002166 BGN/SLC35D2/NDST1/CHST7/CEMIP/CHSY1/FMOD/ANGPT1/B4GALT2/HSPG2/GPC4/HAS2/CHST2/EXT1/ACAN/VCAN/SDC4/NCAN 18 BP GO:0009199 ribonucleoside triphosphate metabolic process 35/819 341/18670 2.875e-06 0.0003065 0.0002351 ENPP1/NADK/CTNS/NME3/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1/CTPS1 35 BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 29/819 256/18670 2.954e-06 0.0003089 0.0002369 GREM1/CRLF1/THBS4/ANGPT1/NTRK2/IL12A/ITGB2/TNFRSF14/GHR/IQGAP1/NRP1/HAX1/ITGB3/PDGFA/CD24/THY1/BST1/STAT3/ARRB2/JAK2/GAS6/SOCS5/IL6ST/SOCS3/MTOR/TSG101/PPP2R1A/ENPP2/PTPN11 29 BP GO:1901214 regulation of neuron death 33/819 313/18670 3.082e-06 0.0003125 0.0002397 CRLF1/CLN3/PIN1/UNC5B/ITGA1/GRN/ANGPT1/NTRK2/CHL1/NUPR1/ITGB2/BCL2L1/NRP1/TFAP2A/MAP3K5/HIF1A/GCLM/STAT3/TGFB2/RASA1/ARRB2/JAK2/GRIN2B/MTOR/RAB29/SIGMAR1/BAD/BCL2/MAP2K4/AP2B1/FZD1/CASP9/FOXO3 33 BP GO:0032869 cellular response to insulin stimulus 26/819 216/18670 3.122e-06 0.0003125 0.0002397 ENPP1/ATP6V0E2/RARRES2/PTPRA/ATP6V0A1/TBC1D4/ATP6V0D1/ATP6V1E1/PIK3R1/IGFBP1/KAT2B/ATP6V0C/INHBB/ATP6V1H/MYO5A/PIK3R2/GRB10/PRKCB/SOCS3/RAB8A/TCIRG1/ATP6V1D/PTPN11/PDK2/FOXO3/NCK1 26 BP GO:0006790 sulfur compound metabolic process 37/819 372/18670 3.161e-06 0.0003125 0.0002397 BGN/ENPP1/SLC35D2/GSTO1/CTNS/NDST1/GGT5/CHST7/MICAL2/CHSY1/PCCB/ACOT13/HMGCL/OGDH/FMOD/ANGPT1/HAGH/GGCT/ELOVL2/B4GALT2/SULT1C2/GHR/IDS/ISCA1/GCLM/CHST2/CIAO1/GPX4/PDK1/MTHFD1/TECR/SULT2B1/ACAN/VCAN/PDK2/BTD/NCAN 37 BP GO:0006732 coenzyme metabolic process 39/819 403/18670 3.353e-06 0.0003227 0.0002475 GSTO1/NADK/IDH2/PCCB/MTHFD2/ACOT13/PCBD1/HMGCL/FDXR/OGDH/FOLR2/ELOVL2/NUPR1/LDHA/QDPR/FMO1/FBP1/SLC25A16/HIF1A/NUP205/NUP93/NUP153/GART/BST1/STAT3/PDK1/SEC13/GPD1L/MTHFD1/FMO2/TECR/COASY/FLAD1/COQ9/PDK2/PGM1/TPI1/BTD/MDH2 39 BP GO:0060337 type I interferon signaling pathway 16/819 95/18670 3.486e-06 0.0003227 0.0002475 IFIT2/OAS1/ISG15/OAS2/ADAR/IFIT1/OASL/IFI35/RSAD2/IFIT3/IFI27/IRF7/PTPN11/MX1/PSMB8/MX2 16 BP GO:0071357 cellular response to type I interferon 16/819 95/18670 3.486e-06 0.0003227 0.0002475 IFIT2/OAS1/ISG15/OAS2/ADAR/IFIT1/OASL/IFI35/RSAD2/IFIT3/IFI27/IRF7/PTPN11/MX1/PSMB8/MX2 16 BP GO:0001935 endothelial cell proliferation 24/819 191/18670 3.501e-06 0.0003227 0.0002475 THBS4/THBS1/SPARC/PRKCA/CXCL12/BMP4/GJA1/SCG2/TGFBR1/VEGFC/PRKD1/NRP1/CCR3/HIF1A/ITGB3/LOXL2/PIK3CB/STAT3/ITGB1BP1/SULF1/MTOR/HTR2B/NRP2/PRKX 24 BP GO:0048010 vascular endothelial growth factor receptor signaling pathway 16/819 96/18670 4.015e-06 0.0003639 0.0002791 MAPKAPK3/EMILIN1/PIK3R1/FOXC1/VEGFC/PRKD1/NRP1/HIF1A/ITGB3/PIK3R2/PIK3CB/GRB10/SULF1/PRKCB/NRP2/NCK1 16 BP GO:0001654 eye development 36/819 362/18670 4.299e-06 0.0003803 0.0002917 COL8A1/COL5A2/CTNS/CRYAB/KDM5B/CYP1B1/NAGLU/EPHB2/BMP4/TGIF2/GJA1/NTRK2/TGFBR1/FOXC1/TDRD7/FBN2/NRP1/TMOD1/TFAP2A/HIF1A/EFEMP1/TUG1/COL4A1/THY1/ARHGEF15/STAT3/TGFB2/KLF4/LAMA1/HMGN1/BCL2/CACNA1C/TCIRG1/ALDH1A3/HSF4/PHACTR4 36 BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 17/819 108/18670 4.53e-06 0.0003803 0.0002917 PSMD8/PSMB7/FZD7/PTK7/PSMD1/FZD2/GPC4/PSMB6/FZD6/ARRB2/WNT11/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 17 BP GO:0070997 neuron death 35/819 348/18670 4.537e-06 0.0003803 0.0002917 CRLF1/CLN3/PIN1/UNC5B/ITGA1/GRN/ADARB1/ANGPT1/NTRK2/CHL1/NUPR1/HSPA5/ITGB2/BCL2L1/NRP1/TFAP2A/MAP3K5/HIF1A/GCLM/STAT3/TGFB2/RASA1/ARRB2/JAK2/GRIN2B/MTOR/RAB29/SIGMAR1/BAD/BCL2/MAP2K4/AP2B1/FZD1/CASP9/FOXO3 35 BP GO:0030111 regulation of Wnt signaling pathway 36/819 363/18670 4.577e-06 0.0003803 0.0002917 SFRP4/GREM1/ARNTL/SIAH2/PSMD8/TCF7L2/PIN1/PSMB7/FZD7/COL1A1/PTK7/BICC1/IGFBP1/MCC/PSMD1/WWTR1/MDFIC/ATP6V0C/SNAI2/ITGA3/PSMB6/FZD6/IGFBP6/RAPGEF1/GRB10/TLE4/SULF1/WNT11/ROR2/PPP2R1A/FZD1/PSMD3/FOXO3/SOX4/PSMD2/PSMB8 36 BP GO:0050678 regulation of epithelial cell proliferation 37/819 378/18670 4.584e-06 0.0003803 0.0002917 VDR/THBS4/MTSS1/THBS1/SPARC/KDM5B/TCF7L2/PRKCA/CXCL12/FZD7/MAGED1/GRN/BMP4/LAMB1/GJA1/SCG2/TGFBR1/VEGFC/PRKD1/NUPR1/MCC/SNAI2/NRP1/CCR3/HIF1A/ITGB3/HAS2/PTPRK/STAT3/TGFB2/SULF1/HMGN1/ZFP36/MTOR/BAD/HTR2B/NRP2 37 BP GO:0007044 cell-substrate junction assembly 16/819 97/18670 4.616e-06 0.0003803 0.0002917 ACTN1/COL16A1/THBS1/MYOC/CD151/IQGAP1/NRP1/PTPRK/GPM6B/THY1/ITGB1BP1/ITGA6/BCL2/ITGA2/PIP5K1A/SDC4 16 BP GO:0009205 purine ribonucleoside triphosphate metabolic process 34/819 335/18670 5.083e-06 0.0004125 0.0003164 ENPP1/NADK/CTNS/NME3/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 34 BP GO:0006885 regulation of pH 16/819 98/18670 5.295e-06 0.000418 0.0003206 MAPK3/ATP6V0E2/SLC4A4/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/SLC4A3/TM9SF4/ATP6V0C/ATP6V1H/BCL2/TCIRG1/ATP6V1D/PDK2 16 BP GO:0071375 cellular response to peptide hormone stimulus 33/819 321/18670 5.31e-06 0.000418 0.0003206 ENPP1/ATP6V0E2/RARRES2/PTPRA/ATP6V0A1/RANGAP1/ADCY8/TBC1D4/ATP6V0D1/ATP6V1E1/PIK3R1/ADCY7/IGFBP1/KAT2B/GHR/ATP6V0C/INHBB/ATP6V1H/MYO5A/PIK3R2/GRB10/STAT3/JAK2/PRKCB/SOCS3/RAB8A/TCIRG1/ATP6V1D/PTPN11/PDK2/FOXO3/GNRHR/NCK1 33 BP GO:0051216 cartilage development 25/819 209/18670 5.381e-06 0.000418 0.0003206 MAPK3/GREM1/SATB2/BMP1/CREB3L2/CHSY1/COL11A1/COL1A1/SERPINH1/COMP/BMP4/TGFBR1/COL14A1/SOX5/SNAI2/COL6A3/HIF1A/EFEMP1/COL7A1/LOXL2/SULF1/WNT11/ROR2/ACAN/CHI3L1 25 BP GO:0150063 visual system development 36/819 366/18670 5.514e-06 0.0004223 0.0003239 COL8A1/COL5A2/CTNS/CRYAB/KDM5B/CYP1B1/NAGLU/EPHB2/BMP4/TGIF2/GJA1/NTRK2/TGFBR1/FOXC1/TDRD7/FBN2/NRP1/TMOD1/TFAP2A/HIF1A/EFEMP1/TUG1/COL4A1/THY1/ARHGEF15/STAT3/TGFB2/KLF4/LAMA1/HMGN1/BCL2/CACNA1C/TCIRG1/ALDH1A3/HSF4/PHACTR4 36 BP GO:0090175 regulation of establishment of planar polarity 17/819 110/18670 5.848e-06 0.0004365 0.0003348 PSMD8/PSMB7/FZD7/PTK7/PSMD1/FZD2/GPC4/PSMB6/FZD6/ARRB2/WNT11/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 17 BP GO:0030178 negative regulation of Wnt signaling pathway 25/819 210/18670 5.859e-06 0.0004365 0.0003348 SFRP4/GREM1/SIAH2/PSMD8/TCF7L2/PSMB7/BICC1/IGFBP1/MCC/PSMD1/WWTR1/SNAI2/PSMB6/FZD6/IGFBP6/RAPGEF1/GRB10/TLE4/WNT11/ROR2/FZD1/PSMD3/FOXO3/PSMD2/PSMB8 25 BP GO:1904035 regulation of epithelial cell apoptotic process 15/819 88/18670 6.011e-06 0.0004396 0.0003371 SFRP4/THBS1/TCF7L2/RAMP2/ANGPT1/SCG2/NUPR1/GSN/ARRB2/JAK2/GAS6/ZFP36/MTOR/BAD/FOXO3 15 BP GO:0034340 response to type I interferon 16/819 99/18670 6.063e-06 0.0004396 0.0003371 IFIT2/OAS1/ISG15/OAS2/ADAR/IFIT1/OASL/IFI35/RSAD2/IFIT3/IFI27/IRF7/PTPN11/MX1/PSMB8/MX2 16 BP GO:0009167 purine ribonucleoside monophosphate metabolic process 34/819 340/18670 7.009e-06 0.0005008 0.0003841 ENPP1/NADK/CTNS/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/GART/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 34 BP GO:0030203 glycosaminoglycan metabolic process 21/819 160/18670 7.109e-06 0.0005008 0.0003841 BGN/SLC35D2/NDST1/CHST7/CEMIP/CHSY1/NAGLU/FMOD/ANGPT1/FOXC1/B4GALT2/HSPG2/IDS/GPC4/HAS2/CHST2/EXT1/ACAN/VCAN/SDC4/NCAN 21 BP GO:0051495 positive regulation of cytoskeleton organization 26/819 226/18670 7.183e-06 0.0005008 0.0003841 HIP1R/MYOC/TGFBR1/NSFL1C/CDC42EP1/TPM1/NRP1/HAX1/MET/ARPC1B/GSN/ARL2/SORBS3/CAV3/ARHGEF15/ITGB1BP1/WNT11/CLIP1/LPAR1/MTOR/BIN1/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 26 BP GO:0051188 cofactor biosynthetic process 33/819 326/18670 7.374e-06 0.0005019 0.0003849 NADK/IDH2/CTNS/GGT5/PCBD1/FDXR/OGDH/HAGH/GGCT/ELOVL2/NUPR1/LDHA/QDPR/FBP1/SLC25A16/HIF1A/NUP205/NUP93/UROS/NUP153/GCLM/GART/STAT3/PDK1/SEC13/MTHFD1/TECR/COASY/FLAD1/COQ9/PDK2/PGM1/TPI1 33 BP GO:0009126 purine nucleoside monophosphate metabolic process 34/819 341/18670 7.466e-06 0.0005019 0.0003849 ENPP1/NADK/CTNS/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/GART/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 34 BP GO:0048880 sensory system development 36/819 371/18670 7.475e-06 0.0005019 0.0003849 COL8A1/COL5A2/CTNS/CRYAB/KDM5B/CYP1B1/NAGLU/EPHB2/BMP4/TGIF2/GJA1/NTRK2/TGFBR1/FOXC1/TDRD7/FBN2/NRP1/TMOD1/TFAP2A/HIF1A/EFEMP1/TUG1/COL4A1/THY1/ARHGEF15/STAT3/TGFB2/KLF4/LAMA1/HMGN1/BCL2/CACNA1C/TCIRG1/ALDH1A3/HSF4/PHACTR4 36 BP GO:0006914 autophagy 44/819 496/18670 7.797e-06 0.0005056 0.0003877 MAPK3/ATP6V0E2/STAM/PLEKHM1/VPS41/CTSA/CLN3/ATP6V0A1/ATP6V0D1/ATP6V1E1/RRAGD/NSFL1C/PRKD1/NUPR1/ATG2A/TMEM41B/ATP6V0C/PIK3C3/LAMTOR5/ATP6V1H/VPS11/HAX1/HIF1A/MET/CLEC16A/PIK3R2/PIK3CB/STAT3/CAPNS1/USP10/RAB8A/CHMP2A/MTOR/TSG101/BAD/BCL2/FBXL2/TCIRG1/HTR2B/ATG4A/ATP6V1D/MAP1LC3B/FOXO3/PIKFYVE 44 BP GO:0061919 process utilizing autophagic mechanism 44/819 496/18670 7.797e-06 0.0005056 0.0003877 MAPK3/ATP6V0E2/STAM/PLEKHM1/VPS41/CTSA/CLN3/ATP6V0A1/ATP6V0D1/ATP6V1E1/RRAGD/NSFL1C/PRKD1/NUPR1/ATG2A/TMEM41B/ATP6V0C/PIK3C3/LAMTOR5/ATP6V1H/VPS11/HAX1/HIF1A/MET/CLEC16A/PIK3R2/PIK3CB/STAT3/CAPNS1/USP10/RAB8A/CHMP2A/MTOR/TSG101/BAD/BCL2/FBXL2/TCIRG1/HTR2B/ATG4A/ATP6V1D/MAP1LC3B/FOXO3/PIKFYVE 44 BP GO:0009144 purine nucleoside triphosphate metabolic process 34/819 342/18670 7.952e-06 0.0005056 0.0003877 ENPP1/NADK/CTNS/NME3/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 34 BP GO:0030641 regulation of cellular pH 15/819 90/18670 7.995e-06 0.0005056 0.0003877 MAPK3/ATP6V0E2/SLC4A4/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/SLC4A3/TM9SF4/ATP6V0C/ATP6V1H/BCL2/TCIRG1/ATP6V1D 15 BP GO:0034333 adherens junction assembly 15/819 90/18670 7.995e-06 0.0005056 0.0003877 ACTN1/COL16A1/THBS1/MYOC/RAMP2/IQGAP1/NRP1/PTPRK/GPM6B/THY1/ITGB1BP1/BCL2/ITGA2/PIP5K1A/SDC4 15 BP GO:1903900 regulation of viral life cycle 20/819 149/18670 8.308e-06 0.0005193 0.0003983 OAS1/RAD23A/ISG15/ADARB1/ADAR/TRIM25/IFIT1/GSN/PPIB/BANF1/OASL/RSAD2/APOBEC3C/CHMP2A/IFI27/TSG101/BCL2/FBXL2/PTX3/MX1 20 BP GO:0006979 response to oxidative stress 41/819 451/18670 8.841e-06 0.0005463 0.000419 MAPK3/PYCR1/ARNTL/CRYAB/STC2/CYP1B1/PXDN/PDLIM1/ATP2A2/COL1A1/TXN/MICB/SOD3/ATOX1/PRKD1/LDHA/ADNP2/TPM1/MAP3K5/HIF1A/MET/EPAS1/TRAP1/PTPRK/MPV17/GCLM/KLF4/GPX4/PDK1/JAK2/GPX3/SIGMAR1/BAD/BCL2/FBLN5/FZD1/CAT/PDK2/TRPC6/PAWR/FOXO3 41 BP GO:0043900 regulation of multi-organism process 38/819 405/18670 9.16e-06 0.0005565 0.0004268 MAPK3/CD55/POLR2L/POLR2E/PRKCA/OAS1/MICB/RAD23A/ISG15/GRN/ADARB1/ADAR/SASH1/TRIM25/CIB1/MDFIC/INHBB/IFIT1/GSN/PPIB/BANF1/OASL/SUPT4H1/RSAD2/ZFP36/APOBEC3C/CHMP2A/CHD1/IFI27/TSG101/UNC13B/BAD/BCL2/PLCB1/FBXL2/PPP2R1A/PTX3/MX1 38 BP GO:0042326 negative regulation of phosphorylation 42/819 468/18670 9.444e-06 0.0005565 0.0004268 ENPP1/GREM1/PIN1/EMILIN1/EPHB2/BMP4/ADARB1/ANGPT1/ADAR/NUPR1/KAT2B/PIK3IP1/WWTR1/CIB1/RASSF2/FBP1/PIK3R2/RAPGEF1/CAV3/ANKLE2/THY1/STAT3/ARRB2/KLF4/ITGB1BP1/RGS2/SOCS5/SOCS3/GPD1L/DUSP7/MTOR/TSG101/HEXIM1/PPP2R1A/PPP2R5D/PHB/CTDSP2/EZR/CDKN2A/PKN1/GMFG/NCK1 42 BP GO:0060828 regulation of canonical Wnt signaling pathway 30/819 286/18670 9.486e-06 0.0005565 0.0004268 SFRP4/GREM1/ARNTL/SIAH2/PSMD8/TCF7L2/PIN1/PSMB7/FZD7/COL1A1/PTK7/BICC1/IGFBP1/MCC/PSMD1/WWTR1/SNAI2/PSMB6/FZD6/IGFBP6/RAPGEF1/TLE4/WNT11/ROR2/FZD1/PSMD3/FOXO3/SOX4/PSMD2/PSMB8 30 BP GO:0031214 biomineral tissue development 21/819 163/18670 9.525e-06 0.0005565 0.0004268 ENPP1/GREM1/COL1A2/COL1A1/ISG15/COMP/BMP4/SLC20A1/GJA1/FBN2/LOX/TFAP2A/HIF1A/CCR1/GPM6B/DDR2/ITGB1BP1/GAS6/WNT11/ROR2/TCIRG1 21 BP GO:0006936 muscle contraction 35/819 360/18670 9.569e-06 0.0005565 0.0004268 GSTO1/CLIC2/CRYAB/TPM2/ATP2A2/ITGA1/COMP/GJA1/GJC1/KCND3/TPM1/NDUFS6/SNTA1/MYLK/TMOD1/PDE4B/SMTN/SORBS3/CAV3/ATP1B1/SULF1/RGS2/STAC/GPD1L/MTOR/CKMT2/SGCA/CACNA1C/HTR2B/CNN1/EDNRA/ITGA2/BIN1/ACTA2/LMOD1 35 BP GO:0050796 regulation of insulin secretion 22/819 176/18670 9.62e-06 0.0005565 0.0004268 NADK/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4 22 BP GO:0032868 response to insulin 29/819 272/18670 9.731e-06 0.000557 0.0004272 ENPP1/ATP6V0E2/RARRES2/PTPRA/ATP6V0A1/TBC1D4/ATP6V0D1/ATP6V1E1/PIK3R1/IGFBP1/KAT2B/ATP6V0C/INHBB/ATP6V1H/HADH/MYO5A/PIK3R2/GRB10/PRKCB/SOCS3/RAB8A/MTOR/TCIRG1/ATP6V1D/CAT/PTPN11/PDK2/FOXO3/NCK1 29 BP GO:0051452 intracellular pH reduction 11/819 51/18670 1.031e-05 0.0005679 0.0004356 ATP6V0E2/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/BCL2/TCIRG1/ATP6V1D 11 BP GO:0051496 positive regulation of stress fiber assembly 11/819 51/18670 1.031e-05 0.0005679 0.0004356 MYOC/TGFBR1/TPM1/NRP1/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 11 BP GO:0007045 cell-substrate adherens junction assembly 14/819 81/18670 1.034e-05 0.0005679 0.0004356 ACTN1/COL16A1/THBS1/MYOC/IQGAP1/NRP1/PTPRK/GPM6B/THY1/ITGB1BP1/BCL2/ITGA2/PIP5K1A/SDC4 14 BP GO:0048041 focal adhesion assembly 14/819 81/18670 1.034e-05 0.0005679 0.0004356 ACTN1/COL16A1/THBS1/MYOC/IQGAP1/NRP1/PTPRK/GPM6B/THY1/ITGB1BP1/BCL2/ITGA2/PIP5K1A/SDC4 14 BP GO:0061448 connective tissue development 29/819 273/18670 1.044e-05 0.0005679 0.0004356 MAPK3/GREM1/SATB2/BMP1/CREB3L2/CHSY1/OXCT1/COL11A1/COL1A1/SERPINH1/COMP/BMP4/TGFBR1/COL14A1/SOX5/SNAI2/LOX/COL6A3/HIF1A/EFEMP1/COL7A1/LOXL2/SULF1/WNT11/ROR2/ACAN/CHI3L1/ACTA2/DYRK1B 29 BP GO:0009141 nucleoside triphosphate metabolic process 35/819 362/18670 1.079e-05 0.000581 0.0004456 ENPP1/NADK/CTNS/NME3/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1/CTPS1 35 BP GO:1902905 positive regulation of supramolecular fiber organization 24/819 204/18670 1.096e-05 0.0005843 0.0004481 HIP1R/MYOC/TGFBR1/CDC42EP1/TPM1/NRP1/MET/ARPC1B/GSN/ARL2/SORBS3/CAV3/ARHGEF15/ITGB1BP1/WNT11/CLIP1/LPAR1/MTOR/BIN1/SDC4/GMFG/RHOBTB2/LMOD1/NCK1 24 BP GO:0032271 regulation of protein polymerization 25/819 218/18670 1.133e-05 0.0005982 0.0004588 HIP1R/ELN/CDC42EP1/TMOD1/CAPZA2/FKBP4/HAX1/MET/ARPC1B/GSN/TWF2/EPS8/ARL2/MAPRE3/CAV3/RASA1/CLIP1/MTOR/CAMSAP2/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 25 BP GO:0032147 activation of protein kinase activity 33/819 333/18670 1.151e-05 0.0006014 0.0004612 MAPK3/GREM1/MAPKAPK3/MAP3K4/FPR1/THBS1/ADCY8/ITGA1/TXN/BMP4/ANGPT1/TGFBR1/ADCY7/MDFIC/GHR/MAP3K5/ITGB3/MAP4K2/PIK3CB/RAPGEF1/TGFB2/ITGB1BP1/JAK2/GAS6/DUSP7/WNT11/LPAR1/MTOR/COPS8/MAP2K4/CHI3L1/PTPN11/PKN1 33 BP GO:0050708 regulation of protein secretion 42/819 472/18670 1.161e-05 0.0006014 0.0004612 MAPK3/NADK/IDH2/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/POSTN/ABCG1/IL1RAP/RFX3/ANGPT1/GJA1/VEGFC/NR1H3/TNFRSF14/PIK3C3/INHBB/MYRIP/HADH/HIF1A/CD2AP/ITPR3/KCNN4/ARL2/TGFB2/JAK2/GAS6/RSAD2/IL4R/UNC13B/BAD/ENSA/CACNA1C/TCIRG1/HTR2B/SPTBN1/PTPN11/PER2/SOX4/EZR 42 BP GO:0051017 actin filament bundle assembly 20/819 153/18670 1.241e-05 0.0006367 0.0004883 ACTN1/MYOC/TGFBR1/PIK3R1/ELN/DPYSL3/TPM1/NRP1/MET/FSCN1/EPS8/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/PAWR/SDC4/EZR 20 BP GO:0060070 canonical Wnt signaling pathway 33/819 335/18670 1.304e-05 0.0006625 0.0005081 SFRP4/GREM1/ARNTL/SIAH2/PSMD8/TCF7L2/PIN1/PSMB7/FZD7/COL1A1/PTK7/BICC1/IGFBP1/MCC/PSMD1/WWTR1/FZD2/SNAI2/PSMB6/FZD6/IGFBP6/RAPGEF1/TLE4/KLF4/WNT11/ROR2/KDM6A/FZD1/PSMD3/FOXO3/SOX4/PSMD2/PSMB8 33 BP GO:0048015 phosphatidylinositol-mediated signaling 22/819 181/18670 1.507e-05 0.0007589 0.000582 MAPK3/MYOC/UNC5B/ANGPT1/NTRK2/PIK3R1/PIK3IP1/PIK3C3/HAX1/GSN/PDGFA/PIK3R2/PIK3CB/TGFB2/KLF4/JAK2/PLCB1/FBXL2/HTR2B/PIP5K1A/CAT/EZR 22 BP GO:0045851 pH reduction 11/819 53/18670 1.524e-05 0.0007601 0.0005829 ATP6V0E2/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/BCL2/TCIRG1/ATP6V1D 11 BP GO:0045069 regulation of viral genome replication 15/819 95/18670 1.572e-05 0.000777 0.0005959 OAS1/RAD23A/ISG15/ADARB1/ADAR/IFIT1/PPIB/BANF1/OASL/RSAD2/APOBEC3C/IFI27/BCL2/FBXL2/MX1 15 BP GO:0051453 regulation of intracellular pH 14/819 84/18670 1.594e-05 0.0007809 0.0005989 ATP6V0E2/SLC4A4/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/SLC4A3/TM9SF4/ATP6V0C/ATP6V1H/BCL2/TCIRG1/ATP6V1D 14 BP GO:0009161 ribonucleoside monophosphate metabolic process 34/819 354/18670 1.652e-05 0.000802 0.0006151 ENPP1/NADK/CTNS/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/GART/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 34 BP GO:0043523 regulation of neuron apoptotic process 24/819 210/18670 1.787e-05 0.0008569 0.0006572 CRLF1/CLN3/PIN1/UNC5B/ITGA1/GRN/ANGPT1/NTRK2/CHL1/NUPR1/BCL2L1/NRP1/TFAP2A/HIF1A/GCLM/TGFB2/RASA1/ARRB2/JAK2/SIGMAR1/BCL2/MAP2K4/CASP9/FOXO3 24 BP GO:0097191 extrinsic apoptotic signaling pathway 25/819 224/18670 1.812e-05 0.0008569 0.0006572 SIAH2/THBS1/TCF7L2/UNC5B/BMP4/SCG2/TGFBR1/PIK3R1/CD70/IL12A/BCL2L1/CIB1/SNAI2/NRP1/GCLM/TGFB2/JAK2/ITGA6/IFI27/BAD/BCL2/PPP2R1A/KRT18/CASP9/FOXO3 25 BP GO:0061572 actin filament bundle organization 20/819 157/18670 1.825e-05 0.0008569 0.0006572 ACTN1/MYOC/TGFBR1/PIK3R1/ELN/DPYSL3/TPM1/NRP1/MET/FSCN1/EPS8/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/PAWR/SDC4/EZR 20 BP GO:0006022 aminoglycan metabolic process 21/819 170/18670 1.828e-05 0.0008569 0.0006572 BGN/SLC35D2/NDST1/CHST7/CEMIP/CHSY1/NAGLU/FMOD/ANGPT1/FOXC1/B4GALT2/HSPG2/IDS/GPC4/HAS2/CHST2/EXT1/ACAN/VCAN/SDC4/NCAN 21 BP GO:0090383 phagosome acidification 8/819 28/18670 1.883e-05 0.0008634 0.0006621 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 BP GO:0009615 response to virus 32/819 326/18670 1.885e-05 0.0008634 0.0006621 IFIT2/CXCL12/OAS1/MICB/APOBEC3B/ISG15/IFI44/ADARB1/OAS2/ADAR/IL12A/BCL2L1/TRIM25/LYST/LAMTOR5/IFIT1/POLR3D/SERINC5/POLR3G/BANF1/OASL/RSAD2/APOBEC3C/IFIT3/IFI27/IRF7/BAD/BCL2/ACTA2/HMGA1/MX1/MX2 32 BP GO:0030004 cellular monovalent inorganic cation homeostasis 16/819 108/18670 1.889e-05 0.0008634 0.0006621 MAPK3/ATP6V0E2/SLC4A4/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/SLC4A3/TM9SF4/ATP6V0C/ATP6V1H/ATP1B1/BCL2/TCIRG1/ATP6V1D 16 BP GO:0051402 neuron apoptotic process 26/819 239/18670 1.95e-05 0.0008787 0.0006739 CRLF1/CLN3/PIN1/UNC5B/ITGA1/GRN/ADARB1/ANGPT1/NTRK2/CHL1/NUPR1/HSPA5/BCL2L1/NRP1/TFAP2A/HIF1A/GCLM/TGFB2/RASA1/ARRB2/JAK2/SIGMAR1/BCL2/MAP2K4/CASP9/FOXO3 26 BP GO:0048017 inositol lipid-mediated signaling 22/819 184/18670 1.955e-05 0.0008787 0.0006739 MAPK3/MYOC/UNC5B/ANGPT1/NTRK2/PIK3R1/PIK3IP1/PIK3C3/HAX1/GSN/PDGFA/PIK3R2/PIK3CB/TGFB2/KLF4/JAK2/PLCB1/FBXL2/HTR2B/PIP5K1A/CAT/EZR 22 BP GO:0007035 vacuolar acidification 7/819 21/18670 2.064e-05 0.0009201 0.0007056 ATP6V0E2/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1H/TCIRG1 7 BP GO:0001704 formation of primary germ layer 17/819 121/18670 2.133e-05 0.0009353 0.0007173 COL8A1/COL5A2/COL11A1/FZD7/BMP4/LAMB1/FOXC1/ITGB2/ITGB3/ITGA3/COL7A1/KLF4/WNT11/KDM6A/ITGA2/COL4A2/ITGB1 17 BP GO:0010811 positive regulation of cell-substrate adhesion 17/819 121/18670 2.133e-05 0.0009353 0.0007173 COL8A1/EDIL3/COL16A1/NID1/MYOC/EMILIN1/CIB1/IQGAP1/NRP1/ITGA3/HAS2/ARL2/THY1/ITGB1BP1/JAK2/ITGA6/SDC4 17 BP GO:0034329 cell junction assembly 26/819 241/18670 2.256e-05 0.0009778 0.0007499 ACTN1/CDH11/COL16A1/THBS1/MYOC/CD151/PRKCA/RAMP2/GJA1/GJC1/IQGAP1/SNAI2/NRP1/PTPRK/FSCN1/GPM6B/ARL2/RAPGEF1/THY1/ITGB1BP1/ITGA6/WNT11/BCL2/ITGA2/PIP5K1A/SDC4 26 BP GO:0043010 camera-type eye development 31/819 314/18670 2.266e-05 0.0009778 0.0007499 COL8A1/CTNS/CRYAB/KDM5B/CYP1B1/EPHB2/BMP4/TGIF2/GJA1/NTRK2/TGFBR1/FOXC1/TDRD7/FBN2/NRP1/TMOD1/TFAP2A/HIF1A/EFEMP1/COL4A1/THY1/ARHGEF15/TGFB2/KLF4/LAMA1/HMGN1/CACNA1C/TCIRG1/ALDH1A3/HSF4/PHACTR4 31 BP GO:0009123 nucleoside monophosphate metabolic process 35/819 375/18670 2.291e-05 0.000981 0.0007523 ENPP1/NADK/CTNS/NDUFB8/AK1/SDHA/OGDH/NUPR1/NDUFAB1/LDHA/NDUFS6/FBP1/TK2/GUK1/NDUFA7/HIF1A/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/GART/COX5B/UQCRQ/STAT3/ATP1B1/SEC13/UQCRC1/COX7A2/BAD/NDUFA1/COQ9/NDUFB7/PGM1/TPI1 35 BP GO:0006929 substrate-dependent cell migration 8/819 29/18670 2.5e-05 0.001062 0.0008147 VEGFC/SNAI2/NRP1/CD2AP/ITGB1BP1/ITGA2/NRP2/NCK1 8 BP GO:0002062 chondrocyte differentiation 17/819 123/18670 2.649e-05 0.001117 0.0008565 GREM1/CREB3L2/CHSY1/COL11A1/SERPINH1/COMP/BMP4/TGFBR1/COL14A1/SOX5/SNAI2/COL6A3/EFEMP1/COL7A1/LOXL2/SULF1/ACAN 17 BP GO:0034599 cellular response to oxidative stress 30/819 302/18670 2.719e-05 0.001131 0.0008675 MAPK3/PYCR1/ARNTL/CYP1B1/ATP2A2/TXN/SOD3/PRKD1/ADNP2/TPM1/MAP3K5/HIF1A/MET/EPAS1/TRAP1/PTPRK/MPV17/KLF4/PDK1/JAK2/GPX3/SIGMAR1/BCL2/FBLN5/FZD1/CAT/PDK2/TRPC6/PAWR/FOXO3 30 BP GO:0043406 positive regulation of MAP kinase activity 27/819 258/18670 2.725e-05 0.001131 0.0008675 MAPK3/MAPKAPK3/MAP3K4/FPR1/THBS1/ITGA1/MAGED1/BMP4/TGFBR1/SASH1/MDFIC/GHR/IQGAP1/MAP3K5/PDGFA/CD24/MAP4K2/PIK3CB/RAPGEF1/JAK2/DUSP7/LPAR1/ROR2/MAP2K4/HTR2B/PTPN11/PKN1 27 BP GO:0060840 artery development 15/819 100/18670 2.943e-05 0.001196 0.0009173 COL3A1/LTBP1/COMP/BMP4/TGFBR1/PLXND1/FOXC1/MYLK/NRP1/LOX/TGFB2/NOTCH3/WNT11/AP2B1/SOX4 15 BP GO:0001736 establishment of planar polarity 17/819 124/18670 2.947e-05 0.001196 0.0009173 PSMD8/PSMB7/FZD7/PTK7/PSMD1/FZD2/GPC4/PSMB6/FZD6/ARRB2/WNT11/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 17 BP GO:0007164 establishment of tissue polarity 17/819 124/18670 2.947e-05 0.001196 0.0009173 PSMD8/PSMB7/FZD7/PTK7/PSMD1/FZD2/GPC4/PSMB6/FZD6/ARRB2/WNT11/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 17 BP GO:0001938 positive regulation of endothelial cell proliferation 16/819 112/18670 3e-05 0.001196 0.0009174 THBS4/PRKCA/CXCL12/BMP4/SCG2/TGFBR1/VEGFC/PRKD1/NRP1/CCR3/HIF1A/ITGB3/STAT3/MTOR/HTR2B/NRP2 16 BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 33/819 349/18670 3.003e-05 0.001196 0.0009174 MAPK3/SFRP4/COL3A1/GREM1/COL1A2/THBS1/LTBP1/PIN1/EMILIN1/COMP/BMP4/FMOD/TGIF2/TGFBR1/HSPA5/LTBP2/WWTR1/INHBB/FBN2/NREP/LOX/ITGA3/NUP93/PTPRK/CAV3/TGFB2/ARRB2/SULF1/ROR2/SPTBN1/FZD1/ZNF423/CREBBP 33 BP GO:0030278 regulation of ossification 23/819 203/18670 3.05e-05 0.001196 0.0009174 MAPK3/ENPP1/GREM1/CHSY1/ISG15/COMP/BMP4/CLIC1/GJA1/PRKD1/RASSF2/FBN2/SNAI2/TFAP2A/HIF1A/CCR1/GPM6B/DDR2/TGFB2/IL6ST/BCL2/TCIRG1/PDLIM7 23 BP GO:0071902 positive regulation of protein serine/threonine kinase activity 32/819 334/18670 3.05e-05 0.001196 0.0009174 MAPK3/MAPKAPK3/MAP3K4/FPR1/THBS1/CEMIP/ITGA1/MAGED1/BMP4/TGFBR1/SASH1/CIB1/CCND2/MDFIC/GHR/IQGAP1/MAP3K5/PDGFA/CD24/MAP4K2/MAPRE3/PIK3CB/RAPGEF1/JAK2/DUSP7/LPAR1/ROR2/MAP2K4/HTR2B/PTPN11/PKN1/CAMK1 32 BP GO:0007162 negative regulation of cell adhesion 29/819 289/18670 3.057e-05 0.001196 0.0009174 THBS1/MYOC/CYP1B1/CXCL12/POSTN/FZD7/COL1A1/BMP4/ANGPT1/PIK3R1/PLXND1/ADAM15/TNFRSF14/SNAI2/PODXL/RASA1/KLF4/ITGB1BP1/PLXNC1/JAK2/SOCS5/IL4R/ADAMDEC1/TNC/PTPN11/PAWR/SDC4/CDKN2A/HLX 29 BP GO:0009408 response to heat 21/819 176/18670 3.095e-05 0.0012 0.00092 MAPK3/IGFBP7/CRYAB/THBS1/CXCL12/ATP2A2/MICB/HSPA5/HSPA2/FKBP4/RPA3/NUP205/NUP93/NUP153/DNAJC2/STAC/SEC13/MTOR/BAG1/HSF4/CREBBP 21 BP GO:0034605 cellular response to heat 18/819 137/18670 3.11e-05 0.0012 0.00092 MAPK3/CRYAB/THBS1/ATP2A2/HSPA5/HSPA2/FKBP4/RPA3/NUP205/NUP93/NUP153/DNAJC2/STAC/SEC13/MTOR/BAG1/HSF4/CREBBP 18 BP GO:0009108 coenzyme biosynthetic process 27/819 261/18670 3.343e-05 0.001279 0.000981 NADK/IDH2/PCBD1/FDXR/OGDH/ELOVL2/NUPR1/LDHA/QDPR/FBP1/SLC25A16/HIF1A/NUP205/NUP93/NUP153/GART/STAT3/PDK1/SEC13/MTHFD1/TECR/COASY/FLAD1/COQ9/PDK2/PGM1/TPI1 27 BP GO:0061299 retina vasculature morphogenesis in camera-type eye 5/819 10/18670 3.364e-05 0.001279 0.000981 CYP1B1/NRP1/COL4A1/ARHGEF15/LAMA1 5 BP GO:0033627 cell adhesion mediated by integrin 12/819 68/18670 3.545e-05 0.001329 0.00102 COL16A1/CYP1B1/ITGB2/CIB1/SNAI2/ITGB3/PODXL/TGFB2/ITGB1BP1/ITGA2/PTPN11/ITGB1 12 BP GO:0071230 cellular response to amino acid stimulus 12/819 68/18670 3.545e-05 0.001329 0.00102 COL5A2/COL3A1/COL16A1/COL1A2/COL1A1/RRAGD/NTRK2/BCL2L1/LAMTOR5/GCLM/COL4A1/MTOR 12 BP GO:0043405 regulation of MAP kinase activity 32/819 337/18670 3.635e-05 0.001354 0.001038 MAPK3/MAPKAPK3/MAP3K4/FPR1/THBS1/ITGA1/EPHB2/MAGED1/BMP4/TGFBR1/SASH1/MDFIC/GHR/IQGAP1/MAP3K5/PDGFA/CD24/MAP4K2/PIK3CB/RAPGEF1/CAV3/RGS2/JAK2/DUSP7/LPAR1/TSG101/ROR2/MAP2K4/HTR2B/PPP2R1A/PTPN11/PKN1 32 BP GO:0060562 epithelial tube morphogenesis 31/819 322/18670 3.683e-05 0.001363 0.001045 VDR/MTSS1/MICAL2/KDM5B/MAGED1/BMP4/PTK7/GJA1/PLXND1/FZD2/NRP1/HIF1A/MET/PODXL/FZD6/COL4A1/CAV3/TGFB2/LAMA1/WNT11/MTHFD1/BCL2/TNC/KDM6A/EDNRA/FZD1/SOX4/SDC4/PHACTR4/PRKX/TMED2 31 BP GO:0030282 bone mineralization 16/819 114/18670 3.747e-05 0.001375 0.001054 ENPP1/GREM1/COL1A2/ISG15/COMP/BMP4/GJA1/FBN2/LOX/TFAP2A/HIF1A/CCR1/GPM6B/DDR2/WNT11/ROR2 16 BP GO:0044272 sulfur compound biosynthetic process 22/819 192/18670 3.792e-05 0.001375 0.001054 BGN/SLC35D2/GSTO1/NDST1/GGT5/CHST7/CHSY1/FMOD/ANGPT1/HAGH/GGCT/ELOVL2/B4GALT2/GCLM/CHST2/PDK1/MTHFD1/TECR/ACAN/VCAN/PDK2/NCAN 22 BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22/819 192/18670 3.792e-05 0.001375 0.001054 GREM1/CRLF1/THBS4/ANGPT1/NTRK2/IL12A/TNFRSF14/GHR/IQGAP1/NRP1/HAX1/ITGB3/CD24/STAT3/ARRB2/JAK2/GAS6/IL6ST/SOCS3/MTOR/ENPP2/PTPN11 22 BP GO:0050679 positive regulation of epithelial cell proliferation 23/819 206/18670 3.849e-05 0.001386 0.001063 THBS4/KDM5B/TCF7L2/PRKCA/CXCL12/FZD7/GRN/BMP4/LAMB1/SCG2/TGFBR1/VEGFC/PRKD1/NRP1/CCR3/HIF1A/ITGB3/HAS2/STAT3/MTOR/BAD/HTR2B/NRP2 23 BP GO:0045333 cellular respiration 22/819 193/18670 4.107e-05 0.001469 0.001127 IDH2/NDUFB8/ACO2/SDHA/OGDH/NDUFAB1/NDUFS6/NDUFA7/HIF1A/NDUFS3/TRAP1/NDUFS7/COX5B/UQCRQ/SDHB/UQCRC1/ETFB/NDUFA1/COQ9/CAT/NDUFB7/MDH2 22 BP GO:0030073 insulin secretion 23/819 207/18670 4.155e-05 0.001472 0.001129 NADK/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/MYO5A/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4 23 BP GO:0009165 nucleotide biosynthetic process 35/819 386/18670 4.179e-05 0.001472 0.001129 NADK/IDH2/NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/PRPSAP2/LDHA/FBP1/TK2/GUK1/HIF1A/CDS1/NUP205/CDS2/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/MTHFD1/RRM2/TECR/AGPAT1/COASY/FLAD1/PDK2/PGM1/TPI1/CTPS1 35 BP GO:0030168 platelet activation 19/819 153/18670 4.195e-05 0.001472 0.001129 MAPK3/COL3A1/COL1A2/PRKCA/COL1A1/COMP/CLIC1/PIK3R1/MYH9/ITPR3/ITGB3/FZD6/PDGFA/PIK3CB/ARRB2/GAS6/PRKCB/PTPN11/TRPC6 19 BP GO:0050900 leukocyte migration 42/819 499/18670 4.311e-05 0.001503 0.001153 MAPK3/GREM1/SLC7A8/RARRES2/COL1A2/THBS4/THBS1/CXCL12/EMILIN1/COL1A1/ITGA1/ANGPT1/SCG2/PIK3R1/VEGFC/IL12A/ITGB2/LYST/ABR/TNFRSF14/MYH9/PDE4B/ITGB3/ITGA3/PSG1/CCR1/EPS8/PIK3R2/PIK3CB/THY1/BST1/ATP1B1/TGFB2/GAS6/ITGA6/IGLL1/ROR2/PLCB1/ITGA2/PTPN11/SDC4/ITGB1 42 BP GO:0010595 positive regulation of endothelial cell migration 17/819 128/18670 4.457e-05 0.001544 0.001184 THBS1/SPARC/PRKCA/GRN/BMP4/ANGPT1/VEGFC/PRKD1/SASH1/CIB1/NRP1/HIF1A/MET/ITGB3/ANXA3/ITGB1BP1/NRP2 17 BP GO:0002791 regulation of peptide secretion 42/819 500/18670 4.514e-05 0.001554 0.001191 MAPK3/NADK/IDH2/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/POSTN/ABCG1/IL1RAP/RFX3/ANGPT1/GJA1/VEGFC/NR1H3/TNFRSF14/PIK3C3/INHBB/MYRIP/HADH/HIF1A/CD2AP/ITPR3/KCNN4/ARL2/TGFB2/JAK2/GAS6/RSAD2/IL4R/UNC13B/BAD/ENSA/CACNA1C/TCIRG1/HTR2B/SPTBN1/PTPN11/PER2/SOX4/EZR 42 BP GO:0001738 morphogenesis of a polarized epithelium 18/819 141/18670 4.588e-05 0.001569 0.001203 PSMD8/PSMB7/FZD7/PTK7/PSMD1/FZD2/GPC4/PSMB6/FZD6/ARRB2/LAMA1/WNT11/ROR2/AP2B1/FZD1/PSMD3/PSMD2/PSMB8 18 BP GO:0006661 phosphatidylinositol biosynthetic process 16/819 116/18670 4.653e-05 0.001581 0.001213 PI4K2A/SYNJ2/PIK3R1/PIK3C3/PIGH/CDS1/PDGFA/PIK3R2/FIG4/PIK3CB/DPM2/INPP5E/HTR2B/SH3YL1/PIP5K1A/PIKFYVE 16 BP GO:0046822 regulation of nucleocytoplasmic transport 15/819 104/18670 4.71e-05 0.001591 0.00122 TCF7L2/RANGAP1/TXN/BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/NUP153/PIK3R2/GAS6/IFI27/PTPN11/MX2/CAMK1 15 BP GO:0001101 response to acid chemical 32/819 343/18670 5.118e-05 0.001702 0.001305 COL5A2/COL3A1/COL16A1/IGFBP7/COL1A2/SPARC/FZD7/COL1A1/HMGCL/MICB/PTK7/RRAGD/FOLR2/GJA1/NTRK2/BCL2L1/ADNP2/PIK3C3/LAMTOR5/GSN/TWF2/GCLM/COL4A1/KLF4/GLRB/WNT11/MTOR/BAD/KCNMB1/TNC/ITGA2/CAT 32 BP GO:1901293 nucleoside phosphate biosynthetic process 35/819 390/18670 5.159e-05 0.001702 0.001305 NADK/IDH2/NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/PRPSAP2/LDHA/FBP1/TK2/GUK1/HIF1A/CDS1/NUP205/CDS2/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/MTHFD1/RRM2/TECR/AGPAT1/COASY/FLAD1/PDK2/PGM1/TPI1/CTPS1 35 BP GO:0033273 response to vitamin 14/819 93/18670 5.171e-05 0.001702 0.001305 VDR/STC2/SPARC/POSTN/COL1A1/FOLR2/TRIM25/SNAI2/TYR/GSN/GAS6/TNC/ITGA2/CAT 14 BP GO:0036473 cell death in response to oxidative stress 14/819 93/18670 5.171e-05 0.001702 0.001305 PYCR1/CYP1B1/TXN/MAP3K5/HIF1A/MET/TRAP1/PDK1/JAK2/SIGMAR1/BCL2/FZD1/PAWR/FOXO3 14 BP GO:0071897 DNA biosynthetic process 22/819 196/18670 5.196e-05 0.001702 0.001305 MAPK3/GREM1/MAP3K4/ISG15/GJA1/RFC3/TRIM25/POLE3/TK2/LOX/RPA3/NEK7/DNAJC2/ARRB2/KLF4/TERF2/USP10/NHP2/CCT7/PHB/POLD2/RCHY1 22 BP GO:1904951 positive regulation of establishment of protein localization 39/819 456/18670 5.684e-05 0.001849 0.001418 MAPK3/NADK/CEMIP/OXCT1/TCF7L2/ADCY8/POSTN/ABCG1/IL1RAP/GJA1/PIK3R1/VEGFC/ITGB2/CIB1/TM9SF4/TNFRSF14/MYRIP/VPS11/HIF1A/CD2AP/KCNN4/PIK3R2/NMT1/TGFB2/ITGB1BP1/JAK2/GAS6/IL4R/RAB29/TSG101/UNC13B/BAD/BCL2/CCT7/HTR2B/SPTBN1/SOX4/EZR/CAMK1 39 BP GO:0061298 retina vasculature development in camera-type eye 6/819 17/18670 5.711e-05 0.001849 0.001418 CYP1B1/NRP1/HIF1A/COL4A1/ARHGEF15/LAMA1 6 BP GO:1901216 positive regulation of neuron death 14/819 94/18670 5.835e-05 0.001876 0.001438 PIN1/ITGA1/GRN/NUPR1/ITGB2/TFAP2A/MAP3K5/TGFB2/GRIN2B/MTOR/BAD/MAP2K4/CASP9/FOXO3 14 BP GO:0043687 post-translational protein modification 33/819 361/18670 5.863e-05 0.001876 0.001438 IGFBP7/ASB1/STC2/LTBP1/PSMD8/PSMB7/BMP4/KLHL21/LAMB1/SCG2/IGFBP1/PSMD1/SPARCL1/HIF1A/PSMB6/EPAS1/ICMT/PNPLA2/GAS6/SOCS5/SOCS3/RAB8A/COPS8/NEDD8/TNC/MBTPS1/RABGGTA/CALU/VCAN/PSMD3/PSMD2/PSMB8/DCAF8 33 BP GO:0006027 glycosaminoglycan catabolic process 11/819 61/18670 6.069e-05 0.001919 0.001472 BGN/CEMIP/NAGLU/FMOD/HSPG2/IDS/GPC4/ACAN/VCAN/SDC4/NCAN 11 BP GO:0032233 positive regulation of actin filament bundle assembly 11/819 61/18670 6.069e-05 0.001919 0.001472 MYOC/TGFBR1/TPM1/NRP1/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 11 BP GO:0003205 cardiac chamber development 20/819 171/18670 6.306e-05 0.00198 0.001518 PCSK5/LTBP1/COL11A1/BMP4/MAML1/PTK7/TGFBR1/PLXND1/FOXC1/FZD2/TPM1/NRP1/HIF1A/CAV3/TGFB2/WNT11/AP2B1/NRP2/FZD1/SOX4 20 BP GO:0090596 sensory organ morphogenesis 26/819 256/18670 6.335e-05 0.00198 0.001518 MAPK3/COL8A1/COL5A2/LRIG1/COL11A1/NAGLU/EPHB2/BMP4/PTK7/NTRK2/TDRD7/FZD2/ABR/FBN2/TFAP2A/HIF1A/EFEMP1/FZD6/TUG1/THY1/STAT3/HMGN1/ROR2/BCL2/ALDH1A3/PHACTR4 26 BP GO:0031032 actomyosin structure organization 22/819 199/18670 6.537e-05 0.002031 0.001557 MYOC/TGFBR1/PIK3R1/ELN/TPM1/MYH9/CSRP2/NRP1/TMOD1/MET/SORBS3/CAV3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/EPB41L1/CNN1/SDC4/LMOD1/ITGB1 22 BP GO:0110020 regulation of actomyosin structure organization 14/819 95/18670 6.572e-05 0.002031 0.001557 MYOC/TGFBR1/PIK3R1/TPM1/NRP1/MET/SORBS3/CAV3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 14 BP GO:0009266 response to temperature stimulus 25/819 243/18670 7.064e-05 0.002166 0.001661 MAPK3/IGFBP7/CRYAB/THBS1/CXCL12/ATP2A2/MICB/HSPA5/HSPA2/FKBP4/RPA3/NUP205/NUP93/NUP153/DNAJC2/UCP2/ARRB2/STAC/SEC13/MTOR/BAG1/GMPR/HTR2B/HSF4/CREBBP 25 BP GO:0051492 regulation of stress fiber assembly 13/819 84/18670 7.091e-05 0.002166 0.001661 MYOC/TGFBR1/PIK3R1/TPM1/NRP1/MET/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 13 BP GO:0051894 positive regulation of focal adhesion assembly 7/819 25/18670 7.317e-05 0.002222 0.001704 COL16A1/MYOC/IQGAP1/NRP1/THY1/ITGB1BP1/SDC4 7 BP GO:0001933 negative regulation of protein phosphorylation 37/819 429/18670 7.354e-05 0.002222 0.001704 ENPP1/GREM1/PIN1/EMILIN1/EPHB2/BMP4/ADARB1/ANGPT1/ADAR/KAT2B/WWTR1/CIB1/RASSF2/PIK3R2/RAPGEF1/CAV3/THY1/ARRB2/KLF4/ITGB1BP1/RGS2/SOCS5/SOCS3/GPD1L/DUSP7/MTOR/TSG101/HEXIM1/PPP2R1A/PPP2R5D/PHB/CTDSP2/EZR/CDKN2A/PKN1/GMFG/NCK1 37 BP GO:0003007 heart morphogenesis 26/819 259/18670 7.693e-05 0.002311 0.001773 MICAL2/COL11A1/BMP4/GJA1/TGFBR1/PLXND1/FOXC1/ELN/ADAM15/FZD2/TPM1/EPHB4/SNAI2/NRP1/HIF1A/HAS2/CAV3/TGFB2/WNT11/MTOR/HTR2B/KDM6A/NRP2/FZD1/SOX4/TMED2 26 BP GO:0046486 glycerolipid metabolic process 36/819 414/18670 7.762e-05 0.002319 0.001779 PLA2G15/PI4K2A/SYNJ2/LPGAT1/PCYT2/SEL1L/ABHD5/PLA2G4C/PIK3R1/NR1H2/NR1H3/PIK3C3/PIGH/SERINC5/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/CAV3/PNPLA2/SOCS5/SOCS3/GPD1L/DPM2/INPP5E/PLCB1/AGPAT1/HTR2B/SH3YL1/PIP5K1A/ENPP2/CAT/PTPN11/PIKFYVE 36 BP GO:0046488 phosphatidylinositol metabolic process 20/819 174/18670 8.058e-05 0.002394 0.001836 PI4K2A/SYNJ2/PLA2G4C/PIK3R1/PIK3C3/PIGH/CDS1/PDGFA/PIK3R2/FIG4/PIK3CB/SOCS5/SOCS3/DPM2/INPP5E/PLCB1/HTR2B/SH3YL1/PIP5K1A/PIKFYVE 20 BP GO:0043902 positive regulation of multi-organism process 21/819 188/18670 8.188e-05 0.002414 0.001852 MAPK3/POLR2L/POLR2E/PRKCA/RAD23A/GRN/ADARB1/ADAR/SASH1/CIB1/MDFIC/INHBB/IFIT1/PPIB/SUPT4H1/CHMP2A/CHD1/TSG101/UNC13B/BAD/PLCB1 21 BP GO:0034330 cell junction organization 28/819 290/18670 8.214e-05 0.002414 0.001852 ACTN1/CDH11/COL16A1/THBS1/MYOC/CD151/PRKCA/RAMP2/GJA1/TGFBR1/GJC1/IQGAP1/SNAI2/NRP1/PTPRK/FSCN1/GPM6B/ARL2/RAPGEF1/THY1/TGFB2/ITGB1BP1/ITGA6/WNT11/BCL2/ITGA2/PIP5K1A/SDC4 28 BP GO:0060348 bone development 23/819 217/18670 8.644e-05 0.002527 0.001938 SFRP4/GREM1/MYOC/SPARC/CHSY1/COL1A1/SERPINH1/COMP/BMP4/GJA1/FOXC1/COL14A1/PRPSAP2/LOX/TFAP2A/COL6A3/HAS2/PPIB/COL7A1/SULF1/PEX7/PTPN11/NAB1 23 BP GO:0014065 phosphatidylinositol 3-kinase signaling 18/819 148/18670 8.711e-05 0.002533 0.001943 MAPK3/MYOC/UNC5B/ANGPT1/NTRK2/PIK3R1/PIK3IP1/HAX1/PDGFA/PIK3R2/PIK3CB/TGFB2/KLF4/JAK2/FBXL2/HTR2B/PIP5K1A/CAT 18 BP GO:0007411 axon guidance 27/819 276/18670 8.768e-05 0.002536 0.001945 MAPK3/PTPRA/DOK1/PRKCA/UNC5B/CXCL12/EPHB2/GAP43/PIK3R1/PLXND1/CHL1/PALLD/EPHB4/NRP1/CHN1/PIK3CB/GRB10/LAMA1/PLXNC1/EXT1/EPHB6/SPTBN1/NRP2/PTPN11/PDLIM7/EZR/VLDLR 27 BP GO:0000302 response to reactive oxygen species 24/819 232/18670 8.981e-05 0.00258 0.001979 MAPK3/PYCR1/CRYAB/CYP1B1/COL1A1/TXN/SOD3/LDHA/TPM1/MAP3K5/MET/TRAP1/PTPRK/MPV17/KLF4/SIGMAR1/BAD/BCL2/FBLN5/CAT/PDK2/TRPC6/PAWR/FOXO3 24 BP GO:1901653 cellular response to peptide 34/819 385/18670 9.016e-05 0.00258 0.001979 ENPP1/ATP6V0E2/RARRES2/PTPRA/ATP6V0A1/RANGAP1/ADCY8/TBC1D4/ATP6V0D1/ATP6V1E1/PIK3R1/ADCY7/IGFBP1/KAT2B/GHR/ATP6V0C/INHBB/ATP6V1H/MYO5A/PIK3R2/GRB10/STAT3/KLF4/JAK2/PRKCB/SOCS3/RAB8A/TCIRG1/ATP6V1D/PTPN11/PDK2/FOXO3/GNRHR/NCK1 34 BP GO:0030038 contractile actin filament bundle assembly 14/819 98/18670 9.29e-05 0.002626 0.002014 MYOC/TGFBR1/PIK3R1/ELN/TPM1/NRP1/MET/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 14 BP GO:0043149 stress fiber assembly 14/819 98/18670 9.29e-05 0.002626 0.002014 MYOC/TGFBR1/PIK3R1/ELN/TPM1/NRP1/MET/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 14 BP GO:0097485 neuron projection guidance 27/819 277/18670 9.321e-05 0.002626 0.002014 MAPK3/PTPRA/DOK1/PRKCA/UNC5B/CXCL12/EPHB2/GAP43/PIK3R1/PLXND1/CHL1/PALLD/EPHB4/NRP1/CHN1/PIK3CB/GRB10/LAMA1/PLXNC1/EXT1/EPHB6/SPTBN1/NRP2/PTPN11/PDLIM7/EZR/VLDLR 27 BP GO:0051222 positive regulation of protein transport 36/819 418/18670 9.431e-05 0.002636 0.002022 MAPK3/NADK/CEMIP/OXCT1/TCF7L2/ADCY8/POSTN/ABCG1/IL1RAP/GJA1/PIK3R1/VEGFC/ITGB2/CIB1/TM9SF4/TNFRSF14/MYRIP/VPS11/HIF1A/CD2AP/KCNN4/PIK3R2/TGFB2/ITGB1BP1/JAK2/GAS6/IL4R/RAB29/TSG101/UNC13B/BAD/HTR2B/SPTBN1/SOX4/EZR/CAMK1 36 BP GO:0001936 regulation of endothelial cell proliferation 20/819 176/18670 9.454e-05 0.002636 0.002022 THBS4/THBS1/SPARC/PRKCA/CXCL12/BMP4/GJA1/SCG2/TGFBR1/VEGFC/PRKD1/NRP1/CCR3/HIF1A/ITGB3/STAT3/SULF1/MTOR/HTR2B/NRP2 20 BP GO:0048592 eye morphogenesis 18/819 149/18670 9.51e-05 0.002639 0.002024 COL8A1/COL5A2/NAGLU/EPHB2/BMP4/NTRK2/TDRD7/FBN2/TFAP2A/HIF1A/EFEMP1/TUG1/THY1/STAT3/HMGN1/BCL2/ALDH1A3/PHACTR4 18 BP GO:0071711 basement membrane organization 7/819 26/18670 9.636e-05 0.00266 0.00204 NID2/NID1/PXDN/RAMP2/LAMB1/COL4A1/ITGB1 7 BP GO:0007409 axonogenesis 39/819 468/18670 9.91e-05 0.002717 0.002083 MAPK3/CDH11/PTPRA/DOK1/TRAK2/PRKCA/UNC5B/CXCL12/EPHB2/ADARB1/GAP43/NTRK2/PIK3R1/PLXND1/CHL1/PALLD/EPHB4/NRP1/CHN1/SPG11/TWF2/PIK3CB/GRB10/THY1/NPTX1/LAMA1/PLXNC1/EXT1/RAB8A/BCL2/EPHB6/SPTBN1/NRP2/MAP1A/PTPN11/PDLIM7/EZR/VLDLR/ITGB1 39 BP GO:0007584 response to nutrient 23/819 219/18670 9.941e-05 0.002717 0.002083 VDR/STC2/SPARC/OXCT1/POSTN/COL1A1/HMGCL/FOLR2/TRIM25/LDHA/SNAI2/TYR/GSN/GCLM/GAS6/MTOR/P2RY2/TNFRSF11B/ENSA/TNC/ITGA2/CAT/PDK2 23 BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 16/819 124/18670 0.000105 0.002849 0.002185 MAPK3/MYOC/UNC5B/ANGPT1/NTRK2/PIK3R1/PIK3IP1/HAX1/PDGFA/PIK3CB/TGFB2/KLF4/JAK2/FBXL2/PIP5K1A/CAT 16 BP GO:0016050 vesicle organization 30/819 325/18670 0.0001053 0.002849 0.002185 PI4K2A/CTSC/STAM/VPS41/HPS1/RAB32/TBC1D4/LYST/PIK3C3/VPS11/GOSR2/CD2AP/NAPA/SPG11/COL7A1/ARFGAP2/SEC13/RAB8A/CHMP2A/TSG101/UNC13B/BCL2/SEC23B/AGFG1/SDC4/TAP1/LMAN1/VAMP3/TMED2/TMF1 30 BP GO:0030500 regulation of bone mineralization 12/819 76/18670 0.0001095 0.002949 0.002261 ENPP1/GREM1/ISG15/COMP/BMP4/GJA1/FBN2/TFAP2A/HIF1A/CCR1/GPM6B/DDR2 12 BP GO:0006026 aminoglycan catabolic process 11/819 65/18670 0.0001108 0.002954 0.002265 BGN/CEMIP/NAGLU/FMOD/HSPG2/IDS/GPC4/ACAN/VCAN/SDC4/NCAN 11 BP GO:0007565 female pregnancy 21/819 192/18670 0.0001108 0.002954 0.002265 MAPK3/VDR/COL16A1/PCSK5/IGFBP7/STC2/RAMP2/GJA1/CLDN4/ADCY7/FKBP4/ITGA3/PSG1/TEAD3/RGS2/MTOR/BCL2/ITGA2/CLIC5/BYSL/TMED2 21 BP GO:0003279 cardiac septum development 15/819 112/18670 0.000112 0.002955 0.002267 PCSK5/LTBP1/BMP4/MAML1/PTK7/TGFBR1/PLXND1/FZD2/NRP1/TGFB2/WNT11/AP2B1/NRP2/FZD1/SOX4 15 BP GO:1903510 mucopolysaccharide metabolic process 15/819 112/18670 0.000112 0.002955 0.002267 BGN/SLC35D2/NDST1/CHST7/CEMIP/CHSY1/FMOD/ANGPT1/B4GALT2/IDS/HAS2/CHST2/ACAN/VCAN/NCAN 15 BP GO:0016999 antibiotic metabolic process 18/819 151/18670 0.0001131 0.00297 0.002278 RENBP/IDH2/CTNS/PXDN/ACO2/SDHA/OGDH/ADH1C/ADH1A/ADH1B/ST6GAL1/STAT3/SDHB/GPX3/GNPDA1/ALDH2/CAT/MDH2 18 BP GO:0010888 negative regulation of lipid storage 6/819 19/18670 0.0001161 0.003036 0.002328 ABCG1/ABHD5/NR1H2/NR1H3/ITGB3/PNPLA2 6 BP GO:0010506 regulation of autophagy 30/819 327/18670 0.0001175 0.003057 0.002344 MAPK3/ATP6V0E2/CTSA/ATP6V0A1/ATP6V0D1/ATP6V1E1/RRAGD/PRKD1/NUPR1/ATP6V0C/LAMTOR5/ATP6V1H/HAX1/HIF1A/MET/CLEC16A/PIK3R2/PIK3CB/STAT3/CAPNS1/USP10/RAB8A/MTOR/BAD/BCL2/FBXL2/HTR2B/ATP6V1D/FOXO3/PIKFYVE 30 BP GO:0044706 multi-multicellular organism process 23/819 222/18670 0.0001221 0.003163 0.002425 MAPK3/VDR/COL16A1/ARNTL/PCSK5/IGFBP7/STC2/RAMP2/GJA1/CLDN4/PLA2G4C/ADCY7/FKBP4/ITGA3/PSG1/TEAD3/RGS2/MTOR/BCL2/ITGA2/CLIC5/BYSL/TMED2 23 BP GO:0043200 response to amino acid 15/819 113/18670 0.000124 0.003195 0.00245 COL5A2/COL3A1/COL16A1/COL1A2/COL1A1/RRAGD/NTRK2/BCL2L1/PIK3C3/LAMTOR5/GCLM/COL4A1/GLRB/MTOR/BAD 15 BP GO:0032201 telomere maintenance via semi-conservative replication 7/819 27/18670 0.0001252 0.003211 0.002463 PRIM2/RFC3/POLE3/RPA3/TERF2/PRIM1/POLD2 7 BP GO:0090276 regulation of peptide hormone secretion 22/819 208/18670 0.000126 0.003216 0.002467 NADK/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4 22 BP GO:0033572 transferrin transport 8/819 36/18670 0.0001342 0.003411 0.002616 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 BP GO:0008154 actin polymerization or depolymerization 22/819 209/18670 0.0001351 0.003417 0.002621 HIP1R/MICAL2/CXCL12/ELN/CDC42EP1/TMOD1/CAPZA2/HAX1/DIAPH1/ARPC1B/GSN/TWF2/EPS8/RASA1/JAK2/MTOR/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 22 BP GO:2000377 regulation of reactive oxygen species metabolic process 21/819 195/18670 0.0001381 0.003463 0.002655 CTNS/PRCP/CRYAB/THBS1/CYP1B1/DDAH2/ARF4/ITGB2/TFAP2A/HIF1A/TRAP1/MPV17/BST1/STAT3/KLF4/JAK2/MTOR/BCL2/FBLN5/PTX3/FOXO3 21 BP GO:0051235 maintenance of location 30/819 330/18670 0.0001382 0.003463 0.002655 ENPP1/GSTO1/CLIC2/CEMIP/LTBP1/KDELR3/RANGAP1/ABCG1/TXN/ABHD5/HSPA5/NR1H2/GM2A/NR1H3/FBN2/MEST/MYO5A/DIAPH1/ITPR3/ITGB3/GSN/TWF2/ARL2/FLNB/THY1/PNPLA2/PLCB1/CACNA1C/HTR2B/EZR 30 BP GO:0072593 reactive oxygen species metabolic process 27/819 284/18670 0.0001414 0.003528 0.002705 CTNS/PRCP/CRYAB/THBS1/CYP1B1/PXDN/DDAH2/SOD3/ARF4/ITGB2/TFAP2A/HIF1A/NDUFS3/TRAP1/MPV17/BST1/STAT3/KLF4/JAK2/GPX3/MTOR/BCL2/FBLN5/SH3PXD2A/PTX3/CAT/FOXO3 27 BP GO:0043491 protein kinase B signaling 26/819 269/18670 0.0001431 0.003553 0.002725 THBS1/MYOC/TCF7L2/TXN/ANGPT1/NTRK2/TGFBR1/PIK3R1/CIB1/LOX/HAX1/MET/PDGFA/PIK3R2/PIK3CB/RAPGEF1/CAV3/ARRB2/KLF4/ITGB1BP1/GAS6/MTOR/RPS6KB2/CHI3L1/PTPN11/ITGB1 26 BP GO:0033157 regulation of intracellular protein transport 23/819 225/18670 0.0001493 0.003677 0.00282 CEMIP/TCF7L2/RANGAP1/TXN/BMP4/ANGPT1/PIK3R1/ITGB2/CIB1/TM9SF4/MDFIC/VPS11/HAX1/NOLC1/PIK3R2/UBE2J1/ITGB1BP1/GAS6/RAB29/IFI27/PTPN11/LMAN1/CAMK1 23 BP GO:0015980 energy derivation by oxidation of organic compounds 27/819 285/18670 0.0001499 0.003677 0.00282 ENPP1/IDH2/NDUFB8/ACO2/SDHA/OGDH/NDUFAB1/NDUFS6/NDUFA7/HIF1A/NDUFS3/TRAP1/NDUFS7/COX5B/UQCRQ/SDHB/IL6ST/UQCRC1/MTOR/ETFB/NDUFA1/COQ9/CAT/NDUFB7/PGM1/PER2/MDH2 27 BP GO:0030041 actin filament polymerization 20/819 182/18670 0.0001501 0.003677 0.00282 HIP1R/ELN/CDC42EP1/TMOD1/CAPZA2/HAX1/DIAPH1/ARPC1B/GSN/TWF2/EPS8/RASA1/JAK2/MTOR/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 20 BP GO:0038065 collagen-activated signaling pathway 5/819 13/18670 0.0001538 0.003751 0.002877 COL1A1/COL4A1/DDR2/ITGA2/COL4A2 5 BP GO:1900034 regulation of cellular response to heat 12/819 79/18670 0.0001603 0.003883 0.002978 MAPK3/CRYAB/FKBP4/RPA3/NUP205/NUP93/NUP153/DNAJC2/SEC13/MTOR/BAG1/CREBBP 12 BP GO:0085029 extracellular matrix assembly 7/819 28/18670 0.0001606 0.003883 0.002978 COL1A2/EMILIN1/LOX/HAS2/GPM6B/GAS6/FBLN5 7 BP GO:0072006 nephron development 17/819 142/18670 0.0001647 0.003945 0.003025 MTSS1/NID1/MAGED1/BMP4/ANGPT1/FOXC1/WWTR1/IQGAP1/ITGA3/PODXL/MPV17/CD24/NOTCH3/SULF1/WNT11/BCL2/ACTA2 17 BP GO:1902904 negative regulation of supramolecular fiber organization 17/819 142/18670 0.0001647 0.003945 0.003025 HIP1R/CRYAB/MYOC/EMILIN1/CIB1/TMOD1/CAPZA2/FKBP4/MET/GSN/TWF2/EPS8/CAV3/CAMSAP2/SPTBN1/GMFG/LMOD1 17 BP GO:0006520 cellular amino acid metabolic process 32/819 366/18670 0.0001726 0.004118 0.003158 PYCR1/CTNS/SLC7A8/GGT5/LARS2/PSMD8/CLN3/PSMB7/PCBD1/HMGCL/DDAH2/OGDH/PSMD1/QDPR/P4HA1/AUH/CKB/TYR/PSMB6/FAH/SERINC5/GCLM/GART/MTHFD1/CKMT2/PSMD3/ALDH7A1/PSMD2/PSMB8/CRYM/BCAT2/CTPS1 32 BP GO:0006650 glycerophospholipid metabolic process 29/819 319/18670 0.0001774 0.004213 0.003231 PLA2G15/PI4K2A/SYNJ2/LPGAT1/PCYT2/ABHD5/PLA2G4C/PIK3R1/PIK3C3/PIGH/SERINC5/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/SOCS5/SOCS3/GPD1L/DPM2/INPP5E/PLCB1/AGPAT1/HTR2B/SH3YL1/PIP5K1A/ENPP2/PIKFYVE 29 BP GO:1903532 positive regulation of secretion by cell 34/819 399/18670 0.0001789 0.00423 0.003244 MAPK3/NADK/STAM/OXCT1/TCF7L2/ADCY8/CXCL12/POSTN/ABCG1/IL1RAP/GJA1/VEGFC/ITGB2/RAB27B/TNFRSF14/INHBB/MYRIP/HIF1A/CD2AP/KCNN4/TGFB2/JAK2/IL4R/CHMP2A/TSG101/UNC13B/BAD/HTR2B/SPTBN1/PTPN11/SOX4/SDC4/EZR/TMF1 34 BP GO:0022904 respiratory electron transport chain 15/819 117/18670 0.0001839 0.004312 0.003307 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/SDHB/UQCRC1/ETFB/NDUFA1/COQ9/NDUFB7 15 BP GO:0006997 nucleus organization 16/819 130/18670 0.000184 0.004312 0.003307 PRKCA/NSFL1C/HABP4/NOLC1/NUP205/USPL1/NUP93/NUP153/BANF1/ANKLE2/PRKCB/CHMP2A/PPP2R1A/BIN1/AGFG1/TMF1 16 BP GO:0007369 gastrulation 20/819 185/18670 0.0001874 0.004374 0.003355 COL8A1/COL5A2/COL11A1/FZD7/BMP4/LAMB1/TGIF2/FOXC1/ITGB2/ITGB3/ITGA3/COL7A1/KLF4/SYF2/EXT1/WNT11/KDM6A/ITGA2/COL4A2/ITGB1 20 BP GO:0051058 negative regulation of small GTPase mediated signal transduction 10/819 58/18670 0.0001924 0.004472 0.00343 MYOC/EPHB2/FBP1/MET/CD2AP/ITGA3/RAPGEF1/TGFB2/RASA1/ITGB1 10 BP GO:0051896 regulation of protein kinase B signaling 24/819 244/18670 0.0001953 0.00452 0.003467 THBS1/MYOC/TCF7L2/TXN/ANGPT1/NTRK2/TGFBR1/PIK3R1/CIB1/HAX1/MET/PDGFA/PIK3R2/PIK3CB/RAPGEF1/CAV3/ARRB2/KLF4/ITGB1BP1/GAS6/MTOR/CHI3L1/PTPN11/ITGB1 24 BP GO:0015682 ferric iron transport 8/819 38/18670 0.0002007 0.004606 0.003533 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 BP GO:0072512 trivalent inorganic cation transport 8/819 38/18670 0.0002007 0.004606 0.003533 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 BP GO:0002063 chondrocyte development 9/819 48/18670 0.0002069 0.004727 0.003625 CHSY1/COL11A1/SERPINH1/COMP/COL14A1/COL6A3/COL7A1/SULF1/ACAN 9 BP GO:0070167 regulation of biomineral tissue development 13/819 94/18670 0.0002282 0.005192 0.003982 ENPP1/GREM1/ISG15/COMP/BMP4/GJA1/FBN2/TFAP2A/HIF1A/CCR1/GPM6B/DDR2/GAS6 13 BP GO:0042542 response to hydrogen peroxide 17/819 146/18670 0.0002308 0.005229 0.00401 PYCR1/CRYAB/CYP1B1/COL1A1/TXN/LDHA/MAP3K5/MET/TRAP1/KLF4/SIGMAR1/BAD/BCL2/CAT/TRPC6/PAWR/FOXO3 17 BP GO:0043393 regulation of protein binding 22/819 217/18670 0.000232 0.005234 0.004014 MAPK3/HIP1R/IFIT2/TCF7L2/PIN1/PCBD1/BMP4/ANGPT1/TGFBR1/PLXND1/HSPA5/ADAM15/NRP1/IFIT1/LOX/MET/MAPRE3/ARRB2/ITGB1BP1/SPON1/BCL2/CAMK1 22 BP GO:0002283 neutrophil activation involved in immune response 39/819 488/18670 0.0002355 0.005292 0.004059 CD55/ATP8A1/PRCP/CTSC/FPR1/PLEKHO2/CTSA/ATP6V0A1/PSMB7/GRN/FOLR3/PSMD1/ITGB2/GM2A/ATP11B/ABR/ATP6V0C/IQGAP1/XRCC6/DIAPH1/GSN/ANXA3/VAT1/SERPINB6/BST1/ASAH1/GLIPR1/DNASE1L3/TCIRG1/CHI3L1/ATP6V1D/PTX3/CAT/HEBP2/PSMD3/PGM1/PSMD2/PTPRB/GMFG 39 BP GO:1901998 toxin transport 8/819 39/18670 0.0002429 0.005437 0.00417 SLC7A8/ATP6V0A1/ABCG1/HSPA5/NRP1/RAB29/CCT7/RAB28 8 BP GO:0043524 negative regulation of neuron apoptotic process 17/819 147/18670 0.0002505 0.005583 0.004282 CRLF1/CLN3/PIN1/UNC5B/GRN/ANGPT1/NTRK2/CHL1/BCL2L1/NRP1/HIF1A/GCLM/RASA1/ARRB2/JAK2/BCL2/MAP2K4 17 BP GO:0016236 macroautophagy 27/819 295/18670 0.0002627 0.005831 0.004472 MAPK3/ATP6V0E2/STAM/CLN3/ATP6V0A1/ATP6V0D1/ATP6V1E1/RRAGD/NSFL1C/NUPR1/ATG2A/TMEM41B/ATP6V0C/PIK3C3/LAMTOR5/ATP6V1H/HIF1A/CLEC16A/CAPNS1/CHMP2A/MTOR/TSG101/TCIRG1/ATG4A/ATP6V1D/MAP1LC3B/PIKFYVE 27 BP GO:0048762 mesenchymal cell differentiation 22/819 219/18670 0.0002641 0.005839 0.004478 MAPK3/GREM1/COL1A1/BMP4/TGFBR1/FOXC1/ADAM15/WWTR1/SNAI2/NRP1/HIF1A/NOLC1/HAS2/LOXL2/TGFB2/WNT11/MTOR/BCL2/HTR2B/EDNRA/NRP2/PHACTR4 22 BP GO:0051494 negative regulation of cytoskeleton organization 17/819 148/18670 0.0002717 0.005979 0.004585 HIP1R/MYOC/KAT2B/CIB1/TMOD1/CAPZA2/FKBP4/MET/GSN/TWF2/EPS8/CAV3/CHMP2A/CAMSAP2/SPTBN1/GMFG/LMOD1 17 BP GO:0051897 positive regulation of protein kinase B signaling 19/819 176/18670 0.0002737 0.005979 0.004585 THBS1/MYOC/TCF7L2/TXN/ANGPT1/TGFBR1/PIK3R1/HAX1/MET/PDGFA/PIK3R2/PIK3CB/ARRB2/ITGB1BP1/GAS6/MTOR/CHI3L1/PTPN11/ITGB1 19 BP GO:0006874 cellular calcium ion homeostasis 37/819 458/18670 0.0002738 0.005979 0.004585 VDR/GSTO1/CD55/CLIC2/FPR1/STC2/CEMIP/CLN3/ADCY8/CXCL12/CCRL2/ATP2A2/GJA1/SV2A/TGM2/MYO5A/CCR3/DIAPH1/ITPR3/CCR1/CD24/PIK3CB/CAV3/THY1/ATP1B1/JAK2/GRIN2B/PRKCB/LPAR1/BCL2/PLCB1/CACNA1C/TCIRG1/HTR2B/EDNRA/TRPC6/GRIN2A 37 BP GO:0030833 regulation of actin filament polymerization 18/819 162/18670 0.0002754 0.00599 0.004594 HIP1R/ELN/CDC42EP1/TMOD1/CAPZA2/HAX1/ARPC1B/GSN/TWF2/EPS8/RASA1/MTOR/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 18 BP GO:0010718 positive regulation of epithelial to mesenchymal transition 9/819 50/18670 0.0002858 0.006142 0.004711 TCF7L2/COL1A1/BMP4/TGFBR1/FOXC1/WWTR1/LOXL2/TGFB2/MTOR 9 BP GO:0042398 cellular modified amino acid biosynthetic process 9/819 50/18670 0.0002858 0.006142 0.004711 GGT5/HAGH/GGCT/CKB/GCLM/GART/MTHFD1/CKMT2/ALDH7A1 9 BP GO:0046854 phosphatidylinositol phosphorylation 9/819 50/18670 0.0002858 0.006142 0.004711 PI4K2A/PIK3R1/PIK3C3/PIK3R2/PIK3CB/SOCS5/SOCS3/PIP5K1A/PIKFYVE 9 BP GO:0051261 protein depolymerization 14/819 109/18670 0.0002927 0.006243 0.004788 MICAL2/SH3GL2/CIB1/TMOD1/CAPZA2/GSN/TWF2/EPS8/CAMSAP2/SPTBN1/MAP1A/KIF2C/CKAP5/LMOD1 14 BP GO:1905477 positive regulation of protein localization to membrane 15/819 122/18670 0.0002927 0.006243 0.004788 CEMIP/EPHB2/PIK3R1/ITGB2/CIB1/ITGA3/NMT1/ITGB1BP1/STAC/BAD/BCL2/AP2B1/SPTBN1/EZR/ITGB1 15 BP GO:0007033 vacuole organization 18/819 163/18670 0.0002972 0.006312 0.004841 VPS41/CLN3/HPS1/NAGLU/GRN/NSFL1C/NUPR1/ATG2A/TMEM41B/LYST/PIK3C3/VPS11/SPG11/FIG4/MBTPS1/ATG4A/MAP1LC3B/PIKFYVE 18 BP GO:0032231 regulation of actin filament bundle assembly 13/819 97/18670 0.000313 0.006567 0.005036 MYOC/TGFBR1/PIK3R1/TPM1/NRP1/MET/SORBS3/ARHGEF15/ITGB1BP1/WNT11/LPAR1/MTOR/SDC4 13 BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 13/819 97/18670 0.000313 0.006567 0.005036 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/UQCRC1/NDUFA1/COQ9/NDUFB7 13 BP GO:0051169 nuclear transport 30/819 346/18670 0.0003139 0.006567 0.005036 THOC1/ARNTL/TCF7L2/RANGAP1/TXN/BMP4/ANGPT1/PIK3R1/MDFIC/DDX39A/NOLC1/NUP205/NUP93/NUP153/RRS1/PIK3R2/BANF1/STAT3/PTTG1IP/GAS6/SEC13/IFI27/MBTPS1/PTPN11/SRSF7/AGFG1/HMGA1/MX2/KPNA3/CAMK1 30 BP GO:0006733 oxidoreduction coenzyme metabolic process 21/819 207/18670 0.000316 0.006567 0.005036 NADK/IDH2/FDXR/OGDH/NUPR1/LDHA/FMO1/FBP1/HIF1A/NUP205/NUP93/NUP153/BST1/STAT3/SEC13/GPD1L/FMO2/COQ9/PGM1/TPI1/MDH2 21 BP GO:0048568 embryonic organ development 35/819 428/18670 0.0003164 0.006567 0.005036 MAPK3/COL5A2/SATB2/PCSK5/RARRES2/LRIG1/MICAL2/COL11A1/NAGLU/EPHB2/BMP4/PTK7/GJA1/TGFBR1/FOXC1/FZD2/ABR/FBN2/TFAP2A/HIF1A/EFEMP1/FZD6/EPAS1/PDGFA/TGFB2/SYF2/SOCS3/WNT11/MTHFD1/ROR2/KDM6A/ALDH1A3/PHACTR4/TMED2/HLX 35 BP GO:0051047 positive regulation of secretion 35/819 428/18670 0.0003164 0.006567 0.005036 MAPK3/NADK/STAM/OXCT1/TCF7L2/ADCY8/CXCL12/POSTN/ABCG1/IL1RAP/GJA1/VEGFC/ITGB2/RAB27B/TNFRSF14/INHBB/MYRIP/HIF1A/CD2AP/KCNN4/TGFB2/JAK2/IL4R/CHMP2A/P2RY2/TSG101/UNC13B/BAD/HTR2B/SPTBN1/PTPN11/SOX4/SDC4/EZR/TMF1 35 BP GO:1903393 positive regulation of adherens junction organization 7/819 31/18670 0.0003181 0.006568 0.005037 COL16A1/MYOC/IQGAP1/NRP1/THY1/ITGB1BP1/SDC4 7 BP GO:0016331 morphogenesis of embryonic epithelium 17/819 150/18670 0.0003189 0.006568 0.005037 BMP4/PTK7/VEGFC/FZD2/TFAP2A/HIF1A/FZD6/TGFB2/SULF1/MTHFD1/KDM6A/FZD1/ALDH1A3/SOX4/SDC4/PHACTR4/TMED2 17 BP GO:0046394 carboxylic acid biosynthetic process 37/819 462/18670 0.0003239 0.006623 0.00508 BGN/PYCR1/GGT5/CEMIP/LPGAT1/OGDH/ELOVL2/NUPR1/NR1H2/NDUFAB1/NR1H3/LDHA/PLP1/FBP1/CYP3A4/MYO5A/CYP27A1/HIF1A/HAS2/SERINC5/NUP205/NUP93/UROS/NUP153/GART/STAT3/GPX4/SEC13/MTHFD1/TECR/ALDH1A3/VCAN/PGM1/PER2/TPI1/NCAN/BCAT2 37 BP GO:0014031 mesenchymal cell development 12/819 85/18670 0.000324 0.006623 0.00508 MAPK3/BMP4/FOXC1/SNAI2/NRP1/HIF1A/NOLC1/BCL2/HTR2B/EDNRA/NRP2/PHACTR4 12 BP GO:0042362 fat-soluble vitamin biosynthetic process 5/819 15/18670 0.0003336 0.006768 0.005191 VDR/SNAI2/CYP3A4/CYP27A1/PLTP 5 BP GO:1903729 regulation of plasma membrane organization 5/819 15/18670 0.0003336 0.006768 0.005191 SH3GL2/MYH9/GSN/TGFB2/PLEKHM2 5 BP GO:0060048 cardiac muscle contraction 16/819 137/18670 0.0003371 0.00679 0.005208 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/TPM1/SNTA1/PDE4B/CAV3/ATP1B1/RGS2/GPD1L/MTOR/CACNA1C/BIN1 16 BP GO:0016053 organic acid biosynthetic process 37/819 463/18670 0.0003377 0.00679 0.005208 BGN/PYCR1/GGT5/CEMIP/LPGAT1/OGDH/ELOVL2/NUPR1/NR1H2/NDUFAB1/NR1H3/LDHA/PLP1/FBP1/CYP3A4/MYO5A/CYP27A1/HIF1A/HAS2/SERINC5/NUP205/NUP93/UROS/NUP153/GART/STAT3/GPX4/SEC13/MTHFD1/TECR/ALDH1A3/VCAN/PGM1/PER2/TPI1/NCAN/BCAT2 37 BP GO:0051607 defense response to virus 23/819 238/18670 0.0003396 0.00679 0.005208 IFIT2/OAS1/MICB/APOBEC3B/ISG15/ADARB1/OAS2/ADAR/TRIM25/LYST/IFIT1/POLR3D/SERINC5/POLR3G/OASL/RSAD2/APOBEC3C/IFIT3/IFI27/IRF7/BCL2/MX1/MX2 23 BP GO:0008064 regulation of actin polymerization or depolymerization 19/819 179/18670 0.0003396 0.00679 0.005208 HIP1R/CXCL12/ELN/CDC42EP1/TMOD1/CAPZA2/HAX1/ARPC1B/GSN/TWF2/EPS8/RASA1/MTOR/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 19 BP GO:0042773 ATP synthesis coupled electron transport 13/819 98/18670 0.0003466 0.006904 0.005295 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/UQCRC1/NDUFA1/COQ9/NDUFB7 13 BP GO:0042119 neutrophil activation 39/819 498/18670 0.0003535 0.007015 0.00538 CD55/ATP8A1/PRCP/CTSC/FPR1/PLEKHO2/CTSA/ATP6V0A1/PSMB7/GRN/FOLR3/PSMD1/ITGB2/GM2A/ATP11B/ABR/ATP6V0C/IQGAP1/XRCC6/DIAPH1/GSN/ANXA3/VAT1/SERPINB6/BST1/ASAH1/GLIPR1/DNASE1L3/TCIRG1/CHI3L1/ATP6V1D/PTX3/CAT/HEBP2/PSMD3/PGM1/PSMD2/PTPRB/GMFG 39 BP GO:0071229 cellular response to acid chemical 21/819 209/18670 0.0003599 0.007105 0.005449 COL5A2/COL3A1/COL16A1/COL1A2/FZD7/COL1A1/PTK7/RRAGD/FOLR2/NTRK2/BCL2L1/ADNP2/LAMTOR5/TWF2/GCLM/COL4A1/KLF4/WNT11/MTOR/KCNMB1/TNC 21 BP GO:0048705 skeletal system morphogenesis 23/819 239/18670 0.0003606 0.007105 0.005449 SFRP4/GREM1/SATB2/BMP1/CHSY1/COL11A1/COL1A1/SERPINH1/COMP/BMP4/TGFBR1/FOXC1/COL14A1/FBN2/TFAP2A/COL6A3/HAS2/COL7A1/PEX7/MTHFD1/ROR2/ACAN/NAB1 23 BP GO:0030832 regulation of actin filament length 19/819 180/18670 0.0003645 0.007156 0.005488 HIP1R/CXCL12/ELN/CDC42EP1/TMOD1/CAPZA2/HAX1/ARPC1B/GSN/TWF2/EPS8/RASA1/MTOR/BIN1/SPTBN1/GMFG/RHOBTB2/LMOD1/NCK1 19 BP GO:0002446 neutrophil mediated immunity 39/819 499/18670 0.0003678 0.007194 0.005517 CD55/ATP8A1/PRCP/CTSC/FPR1/PLEKHO2/CTSA/ATP6V0A1/PSMB7/GRN/FOLR3/PSMD1/ITGB2/GM2A/ATP11B/ABR/ATP6V0C/IQGAP1/XRCC6/DIAPH1/GSN/ANXA3/VAT1/SERPINB6/BST1/ASAH1/GLIPR1/DNASE1L3/TCIRG1/CHI3L1/ATP6V1D/PTX3/CAT/HEBP2/PSMD3/PGM1/PSMD2/PTPRB/GMFG 39 BP GO:0060445 branching involved in salivary gland morphogenesis 6/819 23/18670 0.0003717 0.007245 0.005556 PLXND1/TGM2/SNAI2/NRP1/PDGFA/LAMA1 6 BP GO:0071559 response to transforming growth factor beta 24/819 255/18670 0.0003765 0.007313 0.005608 COL3A1/COL1A2/THBS1/LTBP1/MXRA5/PIN1/EMILIN1/POSTN/COL1A1/FMOD/TGFBR1/HSPA5/SOX5/LTBP2/FBN2/NREP/LOX/ITGA3/PTPRK/CAV3/TGFB2/ARRB2/COL4A2/CREBBP 24 BP GO:0030099 myeloid cell differentiation 34/819 416/18670 0.000387 0.00743 0.005698 ACTN1/THBS1/PRKCA/ISG15/BMP4/PIK3R1/LBR/ADAR/KAT2B/CIB1/MYH9/RASSF2/LOX/HAX1/TNRC6B/HIF1A/EPAS1/PRMT1/CCR1/TSPAN2/STAT3/JAK2/ZFP36/PRKCB/MTOR/IRF7/ROR2/TCIRG1/SH3PXD2A/PTPN11/CASP9/FOXO3/PRKX/CREBBP 34 BP GO:0031346 positive regulation of cell projection organization 32/819 383/18670 0.000388 0.00743 0.005698 PLEKHM1/CREB3L2/CXCL12/GRN/PTK7/NTRK2/TGFBR1/PLXND1/PRKD1/HSPA5/CDC42EP1/DPYSL3/IQGAP1/NRP1/ITGA3/TWF2/FSCN1/EPS8/FIG4/RAPGEF1/PALM/RGS2/PLXNC1/ITGA6/LPAR1/MTOR/ITGA2/FZD1/ENPP2/VLDLR/NCK1/CAMK1 32 BP GO:0045765 regulation of angiogenesis 32/819 383/18670 0.000388 0.00743 0.005698 THBS4/THBS1/SPARC/CYP1B1/PRKCA/EMILIN1/RAMP2/ADAM12/GRN/PLXND1/FOXC1/VEGFC/PRKD1/ITGB2/HSPG2/SASH1/CIB1/NRP1/CCR3/HIF1A/ANXA3/STAT3/TGFB2/RNH1/KLF4/ITGB1BP1/SULF1/PRKCB/CHI3L1/COL4A2/ENPP2/ITGB1 32 BP GO:0046580 negative regulation of Ras protein signal transduction 9/819 52/18670 0.000388 0.00743 0.005698 MYOC/EPHB2/FBP1/MET/ITGA3/RAPGEF1/TGFB2/RASA1/ITGB1 9 BP GO:0071295 cellular response to vitamin 7/819 32/18670 0.0003919 0.007477 0.005735 VDR/POSTN/COL1A1/FOLR2/SNAI2/GAS6/TNC 7 BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 23/819 241/18670 0.000406 0.00772 0.005921 SFRP4/GREM1/THBS1/LTBP1/PIN1/EMILIN1/BMP4/TGFBR1/HSPA5/WWTR1/INHBB/FBN2/NREP/LOX/ITGA3/NUP93/CAV3/TGFB2/SULF1/SPTBN1/FZD1/ZNF423/CREBBP 23 BP GO:0006816 calcium ion transport 35/819 434/18670 0.0004094 0.007757 0.005949 VDR/GSTO1/CLIC2/STC2/CEMIP/CXCL12/ATP2A2/RAMP2/GJA1/HSPA2/MYLK/MYO5A/PDE4B/GNB5/DIAPH1/ITPR3/CCR1/KCNN4/CAV3/THY1/ATP1B1/ARRB2/STAC/GAS6/GRIN2B/PRKCB/BCL2/PLCB1/CACNA1C/HTR2B/BIN1/PHB/ASIC1/TRPC6/GRIN2A 35 BP GO:0043312 neutrophil degranulation 38/819 485/18670 0.0004149 0.007834 0.006008 CD55/ATP8A1/PRCP/CTSC/FPR1/PLEKHO2/CTSA/ATP6V0A1/PSMB7/GRN/FOLR3/PSMD1/ITGB2/GM2A/ATP11B/ABR/ATP6V0C/IQGAP1/XRCC6/DIAPH1/GSN/ANXA3/VAT1/SERPINB6/BST1/ASAH1/GLIPR1/TCIRG1/CHI3L1/ATP6V1D/PTX3/CAT/HEBP2/PSMD3/PGM1/PSMD2/PTPRB/GMFG 38 BP GO:0048562 embryonic organ morphogenesis 26/819 288/18670 0.0004185 0.007874 0.006039 MAPK3/SATB2/LRIG1/MICAL2/COL11A1/NAGLU/EPHB2/BMP4/PTK7/GJA1/TGFBR1/FZD2/ABR/FBN2/TFAP2A/HIF1A/EFEMP1/FZD6/WNT11/MTHFD1/ROR2/KDM6A/ALDH1A3/PHACTR4/TMED2/HLX 26 BP GO:0048863 stem cell differentiation 24/819 257/18670 0.000422 0.007913 0.006069 MAPK3/GREM1/PSMD8/LMO2/PSMB7/BMP4/FOXC1/PSMD1/SOX5/SNAI2/NRP1/HIF1A/NOLC1/PSMB6/STAT3/TGFB2/HTR2B/EDNRA/NRP2/FZD1/PSMD3/PSMD2/PHACTR4/PSMB8 24 BP GO:0034614 cellular response to reactive oxygen species 18/819 168/18670 0.0004301 0.008038 0.006164 MAPK3/PYCR1/CYP1B1/TXN/SOD3/TPM1/MAP3K5/MET/TRAP1/PTPRK/MPV17/KLF4/SIGMAR1/FBLN5/PDK2/TRPC6/PAWR/FOXO3 18 BP GO:0055067 monovalent inorganic cation homeostasis 17/819 154/18670 0.0004347 0.008096 0.006209 MAPK3/ATP6V0E2/SLC4A4/CLN3/ATP6V0A1/GRN/ATP6V0D1/ATP6V1E1/SLC4A3/TM9SF4/ATP6V0C/ATP6V1H/ATP1B1/BCL2/TCIRG1/ATP6V1D/PDK2 17 BP GO:1901888 regulation of cell junction assembly 12/819 88/18670 0.0004486 0.008326 0.006385 COL16A1/THBS1/MYOC/GJA1/IQGAP1/SNAI2/NRP1/GPM6B/RAPGEF1/THY1/ITGB1BP1/SDC4 12 BP GO:0048844 artery morphogenesis 11/819 76/18670 0.0004575 0.008463 0.00649 COL3A1/COMP/BMP4/TGFBR1/FOXC1/MYLK/NRP1/TGFB2/NOTCH3/WNT11/SOX4 11 BP GO:0060349 bone morphogenesis 14/819 114/18670 0.0004665 0.008597 0.006593 SFRP4/CHSY1/COL1A1/SERPINH1/COMP/BMP4/FOXC1/COL14A1/TFAP2A/COL6A3/HAS2/COL7A1/PEX7/NAB1 14 BP GO:0055074 calcium ion homeostasis 37/819 471/18670 0.0004679 0.008597 0.006593 VDR/GSTO1/CD55/CLIC2/FPR1/STC2/CEMIP/CLN3/ADCY8/CXCL12/CCRL2/ATP2A2/GJA1/SV2A/TGM2/MYO5A/CCR3/DIAPH1/ITPR3/CCR1/CD24/PIK3CB/CAV3/THY1/ATP1B1/JAK2/GRIN2B/PRKCB/LPAR1/BCL2/PLCB1/CACNA1C/TCIRG1/HTR2B/EDNRA/TRPC6/GRIN2A 37 BP GO:1901890 positive regulation of cell junction assembly 7/819 33/18670 0.0004788 0.008766 0.006723 COL16A1/MYOC/IQGAP1/NRP1/THY1/ITGB1BP1/SDC4 7 BP GO:0010632 regulation of epithelial cell migration 26/819 291/18670 0.00049 0.00892 0.006841 PRCP/THBS1/SPARC/PRKCA/GRN/BMP4/ANGPT1/VEGFC/PRKD1/MCC/SASH1/CIB1/NRP1/HIF1A/MET/ITGB3/ITGA3/HAS2/ANXA3/TGFB2/KLF4/ITGB1BP1/MTOR/ITGA2/NRP2/ENPP2 26 BP GO:0001953 negative regulation of cell-matrix adhesion 8/819 43/18670 0.0004904 0.00892 0.006841 THBS1/MYOC/POSTN/PIK3R1/ADAM15/RASA1/ITGB1BP1/CDKN2A 8 BP GO:0014823 response to activity 10/819 65/18670 0.0005008 0.009078 0.006962 OXCT1/POSTN/HADH/HIF1A/GCLM/UQCRC1/MTOR/ITGA2/COL4A2/CAT 10 BP GO:0034332 adherens junction organization 16/819 142/18670 0.0005049 0.009121 0.006995 ACTN1/CDH11/COL16A1/THBS1/MYOC/RAMP2/IQGAP1/NRP1/PTPRK/GPM6B/THY1/ITGB1BP1/BCL2/ITGA2/PIP5K1A/SDC4 16 BP GO:0032963 collagen metabolic process 14/819 115/18670 0.0005102 0.009186 0.007045 COL1A2/EMILIN1/COL1A1/SERPINH1/BMP4/ADAM15/FAP/HIF1A/MRC2/COL15A1/ARRB2/MMP17/ITGA2/ITGB1 14 BP GO:1903829 positive regulation of cellular protein localization 28/819 324/18670 0.000517 0.009279 0.007116 CEMIP/TCF7L2/EPHB2/PIK3R1/ITGB2/CIB1/TM9SF4/IQGAP1/VPS11/CD2AP/ITGA3/PIK3R2/NMT1/ITGB1BP1/STAC/GAS6/GPD1L/RAB29/TSG101/BAD/BCL2/CCT7/AP2B1/SPTBN1/MAP1A/EZR/ITGB1/CAMK1 28 BP GO:0032386 regulation of intracellular transport 34/819 423/18670 0.0005223 0.009342 0.007165 MAPK3/CRYAB/CEMIP/TCF7L2/RANGAP1/ATP2A2/TXN/BMP4/ANGPT1/PIK3R1/ITGB2/CIB1/TM9SF4/MDFIC/VPS11/HAX1/NOLC1/NAPA/IL13RA2/NUP153/PIK3R2/UBE2J1/ITGB1BP1/GAS6/PRKCB/IL4R/RAB29/IFI27/UNC13B/PTPN11/LMAN1/EZR/MX2/CAMK1 34 BP GO:1903706 regulation of hemopoiesis 37/819 475/18670 0.0005485 0.009734 0.007465 THBS1/PSMD8/LMO2/PSMB7/PRKCA/ISG15/BMP4/PIK3R1/FOXC1/PSMD1/KAT2B/IL12A/CIB1/RASSF2/LOX/HAX1/TNRC6B/HIF1A/PSMB6/PRMT1/CCR1/STAT3/GAS6/ZFP36/SOCS5/PRKCB/IL4R/MTOR/IRF7/BAD/ROR2/PSMD3/FOXO3/PSMD2/PSMB8/CREBBP/HLX 37 BP GO:0022900 electron transport chain 19/819 186/18670 0.0005495 0.009734 0.007465 NDUFB8/SDHA/NDUFAB1/QDPR/NDUFS6/NDUFA7/NDUFS3/NDUFS7/LOXL2/COX5B/UQCRQ/SDHB/UQCRC1/COX7A2/ETFB/NDUFA1/ALDH2/COQ9/NDUFB7 19 BP GO:0055001 muscle cell development 19/819 186/18670 0.0005495 0.009734 0.007465 PIN1/ATP2A2/RAMP2/COMP/BMP4/MAML1/TPM1/CSRP2/TMOD1/LOX/CAV3/RGS2/MTOR/BCL2/MAP2K4/BIN1/LMOD1/ITGB1/SORBS2 19 BP GO:0097237 cellular response to toxic substance 23/819 247/18670 0.0005737 0.01013 0.007769 GSTO1/PYCR1/ADIRF/CLIC2/CYP1B1/PXDN/TXN/SOD3/ADCY7/MAP3K5/MET/TRAP1/KLF4/GPX4/GPX3/SIGMAR1/BAD/KCNMB1/FBLN5/CAT/TRPC6/PAWR/FOXO3 23 BP GO:0035850 epithelial cell differentiation involved in kidney development 8/819 44/18670 0.0005767 0.01015 0.007782 MTSS1/BMP4/WWTR1/IQGAP1/PODXL/CD24/ACTA2/PRKX 8 BP GO:0007435 salivary gland morphogenesis 7/819 34/18670 0.0005803 0.01015 0.007782 PLXND1/TGM2/SNAI2/NRP1/PDGFA/TGFB2/LAMA1 7 BP GO:0036474 cell death in response to hydrogen peroxide 7/819 34/18670 0.0005803 0.01015 0.007782 PYCR1/TXN/MET/TRAP1/SIGMAR1/PAWR/FOXO3 7 BP GO:0046474 glycerophospholipid biosynthetic process 21/819 217/18670 0.0005934 0.01032 0.007917 PI4K2A/SYNJ2/PCYT2/ABHD5/PIK3R1/PIK3C3/PIGH/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/GPD1L/DPM2/INPP5E/AGPAT1/HTR2B/SH3YL1/PIP5K1A/PIKFYVE 21 BP GO:0050852 T cell receptor signaling pathway 20/819 202/18670 0.0005942 0.01032 0.007917 PSMD8/PSMB7/PIK3R1/PSMD1/PDE4B/PSMB6/KCNN4/PIK3R2/HLA-DRB4/PIK3CB/THY1/HLA-DQB1/RAB29/PSMD3/PAWR/PSMD2/EZR/PSMB8/NCK1/HLA-DPB1 20 BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 9/819 55/18670 0.0005964 0.01033 0.007922 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/COQ9/NDUFB7 9 BP GO:0060333 interferon-gamma-mediated signaling pathway 12/819 91/18670 0.0006114 0.01055 0.008094 OAS1/OAS2/NR1H2/TRIM25/NR1H3/HLA-DRB4/JAK2/OASL/SOCS3/HLA-DQB1/IRF7/HLA-DPB1 12 BP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 13/819 104/18670 0.0006202 0.01064 0.008163 SIAH2/THBS1/TCF7L2/UNC5B/BMP4/SCG2/TGFBR1/BCL2L1/SNAI2/NRP1/GCLM/ITGA6/BCL2 13 BP GO:0003149 membranous septum morphogenesis 4/819 10/18670 0.0006244 0.01064 0.008163 BMP4/FZD2/TGFB2/FZD1 4 BP GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 4/819 10/18670 0.0006244 0.01064 0.008163 COL1A1/COL4A1/DDR2/COL4A2 4 BP GO:0051014 actin filament severing 4/819 10/18670 0.0006244 0.01064 0.008163 MYH9/FLII/GSN/GMFG 4 BP GO:0003151 outflow tract morphogenesis 11/819 79/18670 0.0006409 0.0108 0.008285 BMP4/PLXND1/FOXC1/ELN/FZD2/NRP1/HIF1A/TGFB2/WNT11/NRP2/FZD1 11 BP GO:0021675 nerve development 11/819 79/18670 0.0006409 0.0108 0.008285 LRIG1/EPHB2/ADARB1/NRP1/TFAP2A/SULF1/NPTX1/LPAR1/UNC13B/TCIRG1/NRP2 11 BP GO:0032387 negative regulation of intracellular transport 10/819 67/18670 0.0006412 0.0108 0.008285 CRYAB/RANGAP1/TXN/ANGPT1/MDFIC/IL13RA2/NUP153/UBE2J1/ITGB1BP1/LMAN1 10 BP GO:0071560 cellular response to transforming growth factor beta stimulus 23/819 249/18670 0.0006417 0.0108 0.008285 COL3A1/COL1A2/THBS1/LTBP1/PIN1/EMILIN1/POSTN/COL1A1/FMOD/TGFBR1/HSPA5/SOX5/LTBP2/FBN2/NREP/LOX/ITGA3/PTPRK/CAV3/TGFB2/ARRB2/COL4A2/CREBBP 23 BP GO:0010639 negative regulation of organelle organization 32/819 395/18670 0.0006593 0.01107 0.008486 ESPL1/HIP1R/MYOC/BMP4/TBC1D4/PHF2/NUPR1/KAT2B/BCL2L1/CIB1/TMOD1/CAPZA2/FKBP4/MET/CLEC16A/GSN/TWF2/EPS8/VAT1/CAV3/ARRB2/TERF2/CHMP2A/CAMSAP2/ASF1A/SPTBN1/ANAPC15/IK/HMGA1/LMAN1/GMFG/LMOD1 32 BP GO:0072522 purine-containing compound biosynthetic process 27/819 313/18670 0.0006637 0.01111 0.008517 NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/PRPSAP2/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/MTHFD1/GMPR/TECR/COASY/PDK2/PGM1/TPI1 27 BP GO:0019362 pyridine nucleotide metabolic process 19/819 189/18670 0.0006692 0.01113 0.008535 NADK/IDH2/OGDH/NUPR1/LDHA/FMO1/FBP1/HIF1A/NUP205/NUP93/NUP153/BST1/STAT3/SEC13/GPD1L/FMO2/PGM1/TPI1/MDH2 19 BP GO:0046496 nicotinamide nucleotide metabolic process 19/819 189/18670 0.0006692 0.01113 0.008535 NADK/IDH2/OGDH/NUPR1/LDHA/FMO1/FBP1/HIF1A/NUP205/NUP93/NUP153/BST1/STAT3/SEC13/GPD1L/FMO2/PGM1/TPI1/MDH2 19 BP GO:0045766 positive regulation of angiogenesis 20/819 204/18670 0.0006733 0.01115 0.008554 THBS1/CYP1B1/PRKCA/RAMP2/ADAM12/GRN/VEGFC/PRKD1/ITGB2/SASH1/CIB1/NRP1/CCR3/HIF1A/ANXA3/STAT3/KLF4/PRKCB/CHI3L1/ITGB1 20 BP GO:0048483 autonomic nervous system development 8/819 45/18670 0.0006748 0.01115 0.008554 ADARB1/NRP1/TFAP2A/EDNRA/NRP2/SOX4/PHACTR4/HLX 8 BP GO:0030072 peptide hormone secretion 23/819 250/18670 0.0006782 0.01117 0.008568 NADK/ARNTL/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/MYO5A/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4 23 BP GO:0001841 neural tube formation 13/819 105/18670 0.00068 0.01117 0.008568 BMP4/PTK7/FZD2/HIF1A/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SOX4/SDC4/PHACTR4/TMED2 13 BP GO:0046883 regulation of hormone secretion 24/819 266/18670 0.0006914 0.01132 0.008685 NADK/ARNTL/KDM5B/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4/TMF1 24 BP GO:0006644 phospholipid metabolic process 34/819 430/18670 0.0006977 0.01133 0.008693 PLA2G15/PI4K2A/SYNJ2/CLN3/LPGAT1/PCYT2/ABHD5/PLA2G4C/PIK3R1/PRKD1/PIK3IP1/PIK3C3/PIGH/SERINC5/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/KLF4/GPX4/SOCS5/SOCS3/GPD1L/DPM2/INPP5E/PLCB1/AGPAT1/HTR2B/SH3YL1/PIP5K1A/ENPP2/PIKFYVE 34 BP GO:0048333 mesodermal cell differentiation 7/819 35/18670 0.0006982 0.01133 0.008693 BMP4/ITGB3/ITGA3/KLF4/KDM6A/ITGA2/ITGB1 7 BP GO:0110111 negative regulation of animal organ morphogenesis 7/819 35/18670 0.0006982 0.01133 0.008693 GREM1/BMP4/FOXC1/TGFB2/SULF1/TNFRSF11B/BCL2 7 BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 18/819 175/18670 0.000701 0.01135 0.008701 PSMD8/SH3GL2/PSMB7/PSMD1/CAPZA2/PSMB6/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/PSMD3/TAP1/PSMD2/PSMB8/VAMP3/HLA-DPB1 18 BP GO:0031667 response to nutrient levels 38/819 499/18670 0.0007125 0.0115 0.008817 MAPK3/VDR/STC2/SPARC/CHSY1/OXCT1/SORD/POSTN/COL1A1/HMGCL/RRAGD/FOLR2/PRKD1/HSPA5/TRIM25/LDHA/PIK3C3/INHBB/SNAI2/MAP3K5/TYR/CLEC16A/GSN/GCLM/GAS6/ZFP36/WNT11/MTOR/P2RY2/TNFRSF11B/BCL2/ENSA/TNC/ITGA2/CAT/PDK2/MAP1LC3B/FOXO3 38 BP GO:0045017 glycerolipid biosynthetic process 23/819 251/18670 0.0007165 0.01153 0.008841 PI4K2A/SYNJ2/PCYT2/ABHD5/PIK3R1/NR1H2/NR1H3/PIK3C3/PIGH/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/GPD1L/DPM2/INPP5E/AGPAT1/HTR2B/SH3YL1/PIP5K1A/PIKFYVE 23 BP GO:0010812 negative regulation of cell-substrate adhesion 10/819 68/18670 0.0007227 0.01159 0.008891 THBS1/MYOC/POSTN/FZD7/COL1A1/PIK3R1/ADAM15/RASA1/ITGB1BP1/CDKN2A 10 BP GO:0050714 positive regulation of protein secretion 24/819 268/18670 0.0007684 0.01229 0.009424 MAPK3/NADK/OXCT1/TCF7L2/ADCY8/POSTN/ABCG1/IL1RAP/GJA1/VEGFC/TNFRSF14/MYRIP/HIF1A/CD2AP/KCNN4/TGFB2/JAK2/IL4R/UNC13B/BAD/HTR2B/SPTBN1/SOX4/EZR 24 BP GO:0006164 purine nucleotide biosynthetic process 26/819 300/18670 0.0007728 0.01229 0.009424 NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/PRPSAP2/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/MTHFD1/TECR/COASY/PDK2/PGM1/TPI1 26 BP GO:0046390 ribose phosphate biosynthetic process 26/819 300/18670 0.0007728 0.01229 0.009424 NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/PRPSAP2/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/TECR/COASY/PDK2/PGM1/TPI1/CTPS1 26 BP GO:0043525 positive regulation of neuron apoptotic process 9/819 57/18670 0.0007805 0.01237 0.00949 PIN1/ITGA1/GRN/NUPR1/TFAP2A/TGFB2/MAP2K4/CASP9/FOXO3 9 BP GO:0022612 gland morphogenesis 14/819 120/18670 0.0007845 0.0124 0.00951 VDR/KDM5B/BMP4/PLXND1/TGM2/SNAI2/NRP1/PDGFA/CAV3/TGFB2/SULF1/LAMA1/BCL2/TNC 14 BP GO:0014032 neural crest cell development 11/819 81/18670 0.0007943 0.01252 0.0096 MAPK3/BMP4/FOXC1/SNAI2/NRP1/HIF1A/NOLC1/HTR2B/EDNRA/NRP2/PHACTR4 11 BP GO:0035148 tube formation 16/819 148/18670 0.0007964 0.01252 0.0096 BMP4/PTK7/TGM2/FZD2/HIF1A/PODXL/FZD6/TGFB2/ITGB1BP1/MTHFD1/KDM6A/FZD1/SOX4/SDC4/PHACTR4/TMED2 16 BP GO:0043112 receptor metabolic process 19/819 192/18670 0.0008107 0.01267 0.009716 SFRP4/GREM1/SH3GL2/RAMP2/ANGPT1/ITGB2/NR1H3/HIF1A/ITGB3/CAV3/ARRB2/JAK2/RAB29/HTR2B/AP2B1/EZR/VAMP3/VLDLR/ITGB1 19 BP GO:1901136 carbohydrate derivative catabolic process 19/819 192/18670 0.0008107 0.01267 0.009716 RENBP/BGN/CEMIP/NAGLU/APOBEC3B/FMOD/HSPG2/GM2A/MBD4/PDE4B/IDS/GPC4/APOBEC3C/GPD1L/GNPDA1/ACAN/VCAN/SDC4/NCAN 19 BP GO:0006029 proteoglycan metabolic process 12/819 94/18670 0.000821 0.01279 0.009811 BGN/NDST1/CHST7/CHSY1/TCF7L2/COL11A1/IDS/SULF1/EXT1/ACAN/VCAN/NCAN 12 BP GO:0071634 regulation of transforming growth factor beta production 7/819 36/18670 0.0008344 0.01296 0.009942 THBS1/LTBP1/HIF1A/CD2AP/CD24/TGFB2/WNT11 7 BP GO:0007221 positive regulation of transcription of Notch receptor target 5/819 18/18670 0.0008528 0.01317 0.0101 MAML1/PLXND1/KAT2B/NOTCH3/CREBBP 5 BP GO:0031468 nuclear envelope reassembly 5/819 18/18670 0.0008528 0.01317 0.0101 NSFL1C/BANF1/ANKLE2/CHMP2A/PPP2R1A 5 BP GO:1901215 negative regulation of neuron death 20/819 208/18670 0.0008592 0.01324 0.01015 CRLF1/CLN3/PIN1/UNC5B/GRN/ANGPT1/NTRK2/CHL1/BCL2L1/NRP1/HIF1A/GCLM/STAT3/RASA1/ARRB2/JAK2/BCL2/MAP2K4/AP2B1/FZD1 20 BP GO:0050921 positive regulation of chemotaxis 15/819 135/18670 0.0008644 0.01328 0.01018 MAPK3/RARRES2/THBS4/THBS1/CXCL12/SCG2/VEGFC/PRKD1/IL12A/NRP1/MET/CCR1/GAS6/LPAR1/ITGA2 15 BP GO:0033002 muscle cell proliferation 22/819 239/18670 0.0008722 0.01336 0.01025 THBS1/TCF7L2/BMP4/ANGPT1/GJA1/TGFBR1/FOXC1/ELN/IL12A/TGM2/TPM1/ABCC4/XRCC6/MAP3K5/STAT3/TGFB2/NOTCH3/KLF4/JAK2/MTOR/CNN1/ITGA2 22 BP GO:0007204 positive regulation of cytosolic calcium ion concentration 27/819 319/18670 0.0008843 0.01351 0.01036 GSTO1/CD55/CLIC2/FPR1/CEMIP/ADCY8/CCRL2/GJA1/TGM2/MYO5A/CCR3/DIAPH1/ITPR3/CCR1/CD24/CAV3/THY1/JAK2/GRIN2B/LPAR1/BCL2/PLCB1/CACNA1C/HTR2B/EDNRA/TRPC6/GRIN2A 27 BP GO:0007596 blood coagulation 28/819 336/18670 0.0009103 0.01387 0.01063 MAPK3/COL3A1/PRCP/COL1A2/THBS1/PRKCA/COL1A1/COMP/CLIC1/PIK3R1/AKAP1/MYH9/FAP/CAPZA2/ITPR3/ITGB3/FZD6/PDGFA/PIK3CB/ARRB2/JAK2/GAS6/PRKCB/ITGA2/PTPN11/VPS45/TRPC6/LMAN1 28 BP GO:0050777 negative regulation of immune response 16/819 150/18670 0.000921 0.01399 0.01073 COL3A1/CD55/THOC1/GRN/ANGPT1/ADAR/NR1H2/NR1H3/ABR/TNFRSF14/IL13RA2/TGFB2/ARRB2/SOCS5/IL4R/HLX 16 BP GO:0046939 nucleotide phosphorylation 15/819 136/18670 0.0009331 0.01411 0.01082 NME3/AK1/OGDH/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 15 BP GO:0060384 innervation 6/819 27/18670 0.0009382 0.01411 0.01082 LRIG1/ADARB1/NRP1/SULF1/NPTX1/UNC13B 6 BP GO:0060326 cell chemotaxis 26/819 304/18670 0.0009386 0.01411 0.01082 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/CCRL2/ITGA1/SCG2/VEGFC/PRKD1/IL12A/ITGB2/LYST/NRP1/LOX/PDE4B/CCR3/MET/CCR1/BST1/TGFB2/ARRB2/GAS6/LPAR1/PIP5K1A 26 BP GO:0019042 viral latency 4/819 11/18670 0.0009472 0.01411 0.01082 XRCC6/BANF1/IRF7/HMGA1 4 BP GO:0032060 bleb assembly 4/819 11/18670 0.0009472 0.01411 0.01082 EMP3/MYLK/PMP22/LPAR1 4 BP GO:0070106 interleukin-27-mediated signaling pathway 4/819 11/18670 0.0009472 0.01411 0.01082 CRLF1/STAT3/JAK2/IL6ST 4 BP GO:0070757 interleukin-35-mediated signaling pathway 4/819 11/18670 0.0009472 0.01411 0.01082 IL12A/STAT3/JAK2/IL6ST 4 BP GO:0072524 pyridine-containing compound metabolic process 19/819 195/18670 0.0009771 0.01452 0.01113 NADK/IDH2/OGDH/NUPR1/LDHA/FMO1/FBP1/HIF1A/NUP205/NUP93/NUP153/BST1/STAT3/SEC13/GPD1L/FMO2/PGM1/TPI1/MDH2 19 BP GO:0007431 salivary gland development 7/819 37/18670 0.0009906 0.01462 0.01121 PLXND1/TGM2/SNAI2/NRP1/PDGFA/TGFB2/LAMA1 7 BP GO:1990823 response to leukemia inhibitory factor 12/819 96/18670 0.0009917 0.01462 0.01121 KDM5B/VEGFC/TRIM25/EPS8/GCLM/TLE4/KLF4/SOCS3/NRP2/SRSF7/BCAT2/NFYB 12 BP GO:1990830 cellular response to leukemia inhibitory factor 12/819 96/18670 0.0009917 0.01462 0.01121 KDM5B/VEGFC/TRIM25/EPS8/GCLM/TLE4/KLF4/SOCS3/NRP2/SRSF7/BCAT2/NFYB 12 BP GO:1901342 regulation of vasculature development 33/819 422/18670 0.001002 0.0147 0.01127 THBS4/THBS1/SPARC/CYP1B1/PRKCA/EMILIN1/RAMP2/ADAM12/GRN/BMP4/PLXND1/FOXC1/VEGFC/PRKD1/ITGB2/HSPG2/SASH1/CIB1/NRP1/CCR3/HIF1A/ANXA3/STAT3/TGFB2/RNH1/KLF4/ITGB1BP1/SULF1/PRKCB/CHI3L1/COL4A2/ENPP2/ITGB1 33 BP GO:0019882 antigen processing and presentation 21/819 226/18670 0.001004 0.0147 0.01127 THBS1/PSMD8/SH3GL2/PSMB7/RAB32/RAB33A/PSMD1/CAPZA2/PSMB6/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/PSMD3/TAP1/PSMD2/PSMB8/VAMP3/HLA-DPB1 21 BP GO:0008333 endosome to lysosome transport 9/819 59/18670 0.001008 0.0147 0.01127 DENND3/VPS41/TRAK2/LYST/VPS11/CLEC16A/SNX27/TSG101/BIN1 9 BP GO:0046847 filopodium assembly 9/819 59/18670 0.001008 0.0147 0.01127 GAP43/TGFBR1/MYO10/DPYSL3/NRP1/FSCN1/PALM/ITGA6/EZR 9 BP GO:0071496 cellular response to external stimulus 28/819 339/18670 0.001042 0.01512 0.01159 MAPK3/VDR/POSTN/COL1A1/RRAGD/FOLR2/GJA1/PRKD1/HSPA5/HABP4/PIK3C3/INHBB/SNAI2/MAP3K5/CLEC16A/GAS6/ITGA6/WNT11/MTOR/P2RY2/BAD/BCL2/MAP2K4/TNC/ITGA2/PTPN11/PDK2/MAP1LC3B 28 BP GO:2001233 regulation of apoptotic signaling pathway 32/819 406/18670 0.001042 0.01512 0.01159 CTSC/HIP1R/NACC2/SIAH2/THBS1/TCF7L2/UNC5B/CXCL12/MAGED1/BMP4/SCG2/HRK/TGFBR1/NUPR1/BCL2L1/INHBB/SNAI2/NRP1/HIF1A/NDUFS3/GSN/TRAP1/GCLM/NMT1/ARRB2/PTTG1IP/JAK2/ITGA6/BAD/BCL2/PPP2R1A/NCK1 32 BP GO:0035272 exocrine system development 8/819 48/18670 0.001052 0.01522 0.01167 PLXND1/FOXC1/TGM2/SNAI2/NRP1/PDGFA/TGFB2/LAMA1 8 BP GO:0051098 regulation of binding 30/819 373/18670 0.001075 0.0155 0.01189 MAPK3/CLIC2/HIP1R/IFIT2/TCF7L2/PIN1/PCBD1/TXN/BMP4/ANGPT1/TGFBR1/PLXND1/FOXC1/HSPA5/HABP4/ADAM15/NRP1/IFIT1/LOX/MET/MAPRE3/ARRB2/KLF4/ITGB1BP1/JAK2/SPON1/BCL2/ITGA2/PER2/CAMK1 30 BP GO:0072503 cellular divalent inorganic cation homeostasis 37/819 493/18670 0.001083 0.01552 0.0119 VDR/GSTO1/CD55/CLIC2/FPR1/STC2/CEMIP/CLN3/ADCY8/CXCL12/CCRL2/ATP2A2/GJA1/SV2A/TGM2/MYO5A/CCR3/DIAPH1/ITPR3/CCR1/CD24/PIK3CB/CAV3/THY1/ATP1B1/JAK2/GRIN2B/PRKCB/LPAR1/BCL2/PLCB1/CACNA1C/TCIRG1/HTR2B/EDNRA/TRPC6/GRIN2A 37 BP GO:0009135 purine nucleoside diphosphate metabolic process 15/819 138/18670 0.001084 0.01552 0.0119 AK1/OGDH/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 15 BP GO:0009179 purine ribonucleoside diphosphate metabolic process 15/819 138/18670 0.001084 0.01552 0.0119 AK1/OGDH/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 15 BP GO:0014020 primary neural tube formation 12/819 97/18670 0.001088 0.01552 0.0119 BMP4/PTK7/FZD2/HIF1A/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SDC4/PHACTR4/TMED2 12 BP GO:0071356 cellular response to tumor necrosis factor 25/819 291/18670 0.001094 0.01558 0.01195 MAPK3/THBS1/PSMD8/PSMB7/POSTN/COL1A1/CD70/PSMD1/CIB1/TNFRSF14/MAP3K5/PSMB6/HAS2/JAK2/GAS6/ZFP36/TNFRSF17/ASAH1/TNFRSF11B/CHI3L1/KRT18/PSMD3/FOXO3/PSMD2/PSMB8 25 BP GO:0019884 antigen processing and presentation of exogenous antigen 18/819 182/18670 0.001107 0.01568 0.01202 PSMD8/SH3GL2/PSMB7/PSMD1/CAPZA2/PSMB6/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/PSMD3/TAP1/PSMD2/PSMB8/VAMP3/HLA-DPB1 18 BP GO:0061138 morphogenesis of a branching epithelium 18/819 182/18670 0.001107 0.01568 0.01202 VDR/KDM5B/MAGED1/BMP4/PLXND1/TGM2/SNAI2/NRP1/MET/PDGFA/COL4A1/CAV3/SULF1/LAMA1/SOCS3/BCL2/TNC/EDNRA 18 BP GO:0045063 T-helper 1 cell differentiation 5/819 19/18670 0.001116 0.01576 0.01209 IL18R1/SOCS5/IL4R/MTOR/HLX 5 BP GO:0032024 positive regulation of insulin secretion 10/819 72/18670 0.001139 0.01595 0.01223 NADK/OXCT1/TCF7L2/ADCY8/GJA1/MYRIP/HIF1A/JAK2/BAD/SOX4 10 BP GO:0007599 hemostasis 28/819 341/18670 0.001139 0.01595 0.01223 MAPK3/COL3A1/PRCP/COL1A2/THBS1/PRKCA/COL1A1/COMP/CLIC1/PIK3R1/AKAP1/MYH9/FAP/CAPZA2/ITPR3/ITGB3/FZD6/PDGFA/PIK3CB/ARRB2/JAK2/GAS6/PRKCB/ITGA2/PTPN11/VPS45/TRPC6/LMAN1 28 BP GO:0051893 regulation of focal adhesion assembly 9/819 60/18670 0.001141 0.01595 0.01223 COL16A1/THBS1/MYOC/IQGAP1/NRP1/GPM6B/THY1/ITGB1BP1/SDC4 9 BP GO:0090109 regulation of cell-substrate junction assembly 9/819 60/18670 0.001141 0.01595 0.01223 COL16A1/THBS1/MYOC/IQGAP1/NRP1/GPM6B/THY1/ITGB1BP1/SDC4 9 BP GO:0031623 receptor internalization 13/819 111/18670 0.00115 0.01604 0.0123 SFRP4/GREM1/SH3GL2/RAMP2/ANGPT1/ITGB2/ITGB3/CAV3/ARRB2/HTR2B/AP2B1/EZR/ITGB1 13 BP GO:0008654 phospholipid biosynthetic process 23/819 260/18670 0.001155 0.01605 0.01231 PI4K2A/SYNJ2/LPGAT1/PCYT2/ABHD5/PIK3R1/PIK3C3/PIGH/SERINC5/CDS1/CDS2/PDGFA/PIK3R2/FIG4/PIK3CB/GPD1L/DPM2/INPP5E/AGPAT1/HTR2B/SH3YL1/PIP5K1A/PIKFYVE 23 BP GO:0007223 Wnt signaling pathway, calcium modulating pathway 7/819 38/18670 0.001169 0.01605 0.01231 TCF7L2/FZD2/TNRC6B/FZD6/WNT11/ROR2/PLCB1 7 BP GO:0046825 regulation of protein export from nucleus 7/819 38/18670 0.001169 0.01605 0.01231 TCF7L2/RANGAP1/TXN/GAS6/IFI27/PTPN11/CAMK1 7 BP GO:0051693 actin filament capping 7/819 38/18670 0.001169 0.01605 0.01231 TMOD1/CAPZA2/GSN/TWF2/EPS8/SPTBN1/LMOD1 7 BP GO:0071604 transforming growth factor beta production 7/819 38/18670 0.001169 0.01605 0.01231 THBS1/LTBP1/HIF1A/CD2AP/CD24/TGFB2/WNT11 7 BP GO:1904037 positive regulation of epithelial cell apoptotic process 7/819 38/18670 0.001169 0.01605 0.01231 SFRP4/THBS1/GSN/ARRB2/JAK2/BAD/FOXO3 7 BP GO:0050817 coagulation 28/819 342/18670 0.001191 0.01626 0.01247 MAPK3/COL3A1/PRCP/COL1A2/THBS1/PRKCA/COL1A1/COMP/CLIC1/PIK3R1/AKAP1/MYH9/FAP/CAPZA2/ITPR3/ITGB3/FZD6/PDGFA/PIK3CB/ARRB2/JAK2/GAS6/PRKCB/ITGA2/PTPN11/VPS45/TRPC6/LMAN1 28 BP GO:0048864 stem cell development 11/819 85/18670 0.001193 0.01626 0.01247 MAPK3/BMP4/FOXC1/SNAI2/NRP1/HIF1A/NOLC1/HTR2B/EDNRA/NRP2/PHACTR4 11 BP GO:1903901 negative regulation of viral life cycle 11/819 85/18670 0.001193 0.01626 0.01247 OAS1/ISG15/TRIM25/IFIT1/GSN/BANF1/OASL/RSAD2/APOBEC3C/PTX3/MX1 11 BP GO:0009260 ribonucleotide biosynthetic process 25/819 293/18670 0.001205 0.01638 0.01256 NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/TECR/COASY/PDK2/PGM1/TPI1/CTPS1 25 BP GO:0007517 muscle organ development 32/819 410/18670 0.001224 0.0166 0.01273 COL3A1/GREM1/ARNTL/CRYAB/COL11A1/PIN1/FZD7/BMP4/TAGLN/ADARB1/GJA1/TGFBR1/FOXC1/ELN/NUPR1/FZD2/TPM1/MYLK/LOX/COL6A3/SMTN/FLNB/CAV3/TGFB2/ARRB2/RGS2/MTOR/SGCA/BCL2/FZD1/TEAD4/HLX 32 BP GO:0006913 nucleocytoplasmic transport 28/819 343/18670 0.001244 0.01674 0.01284 THOC1/ARNTL/TCF7L2/RANGAP1/TXN/BMP4/ANGPT1/PIK3R1/MDFIC/DDX39A/NOLC1/NUP205/NUP93/NUP153/RRS1/PIK3R2/STAT3/PTTG1IP/GAS6/SEC13/IFI27/MBTPS1/PTPN11/SRSF7/AGFG1/MX2/KPNA3/CAMK1 28 BP GO:0072330 monocarboxylic acid biosynthetic process 28/819 343/18670 0.001244 0.01674 0.01284 BGN/LPGAT1/OGDH/ELOVL2/NUPR1/NR1H2/NDUFAB1/NR1H3/LDHA/PLP1/FBP1/CYP3A4/MYO5A/CYP27A1/HIF1A/NUP205/NUP93/NUP153/STAT3/GPX4/SEC13/TECR/ALDH1A3/VCAN/PGM1/PER2/TPI1/NCAN 28 BP GO:0007179 transforming growth factor beta receptor signaling pathway 19/819 199/18670 0.001244 0.01674 0.01284 COL3A1/COL1A2/THBS1/LTBP1/PIN1/EMILIN1/FMOD/TGFBR1/HSPA5/LTBP2/FBN2/NREP/LOX/ITGA3/PTPRK/CAV3/TGFB2/ARRB2/CREBBP 19 BP GO:1903828 negative regulation of cellular protein localization 13/819 112/18670 0.00125 0.01678 0.01287 RANGAP1/TXN/ANGPT1/NSFL1C/BCL2L1/MDFIC/GPM6B/UBE2J1/CAV3/ITGB1BP1/INPP5E/MAP1A/LMAN1 13 BP GO:0001837 epithelial to mesenchymal transition 15/819 140/18670 0.001256 0.01678 0.01287 GREM1/COL1A1/BMP4/TGFBR1/FOXC1/ADAM15/WWTR1/SNAI2/HIF1A/NOLC1/HAS2/LOXL2/TGFB2/WNT11/MTOR 15 BP GO:0009185 ribonucleoside diphosphate metabolic process 15/819 140/18670 0.001256 0.01678 0.01287 AK1/OGDH/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 15 BP GO:0060350 endochondral bone morphogenesis 10/819 73/18670 0.001269 0.01687 0.01294 COL1A1/SERPINH1/COMP/BMP4/FOXC1/COL14A1/COL6A3/COL7A1/PEX7/NAB1 10 BP GO:0046031 ADP metabolic process 14/819 126/18670 0.001269 0.01687 0.01294 AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 14 BP GO:0060485 mesenchyme development 24/819 278/18670 0.001276 0.01692 0.01298 MAPK3/GREM1/COL1A1/BMP4/PTK7/TGFBR1/FOXC1/ADAM15/WWTR1/SNAI2/NRP1/HIF1A/NOLC1/HAS2/LOXL2/TGFB2/WNT11/MTOR/BCL2/HTR2B/EDNRA/NRP2/ACTA2/PHACTR4 24 BP GO:0034504 protein localization to nucleus 23/819 262/18670 0.001279 0.01692 0.01298 ARNTL/RANGAP1/PIN1/COL1A1/TXN/BMP4/ANGPT1/PIK3R1/MDFIC/CD2AP/NOLC1/NUP93/NUP153/RRS1/PIK3R2/ARL2/STAT3/PTTG1IP/CCT7/MBTPS1/PIKFYVE/BYSL/KPNA3 23 BP GO:0048525 negative regulation of viral process 12/819 99/18670 0.001302 0.01719 0.01318 OAS1/ISG15/TRIM25/IFIT1/GSN/BANF1/OASL/RSAD2/ZFP36/APOBEC3C/PTX3/MX1 12 BP GO:0006069 ethanol oxidation 4/819 12/18670 0.001372 0.01797 0.01378 ADH1C/ADH1A/ADH1B/ALDH2 4 BP GO:0042368 vitamin D biosynthetic process 4/819 12/18670 0.001372 0.01797 0.01378 VDR/SNAI2/CYP3A4/CYP27A1 4 BP GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 4/819 12/18670 0.001372 0.01797 0.01378 MET/TRAP1/PAWR/FOXO3 4 BP GO:0060976 coronary vasculature development 8/819 50/18670 0.001386 0.01807 0.01386 PCSK5/LTBP1/BMP4/PTK7/TGFBR1/PLXND1/NRP1/AP2B1 8 BP GO:2000725 regulation of cardiac muscle cell differentiation 8/819 50/18670 0.001386 0.01807 0.01386 GREM1/PIN1/FZD7/BMP4/CAV3/ARRB2/RGS2/MTOR 8 BP GO:0015949 nucleobase-containing small molecule interconversion 6/819 29/18670 0.001397 0.01818 0.01394 NME3/AK1/GUK1/RRM2/GMPR/CTPS1 6 BP GO:0009152 purine ribonucleotide biosynthetic process 24/819 280/18670 0.001406 0.01825 0.01399 NME3/AK1/ADCY8/OGDH/ELOVL2/ADCY7/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/PDK1/SEC13/TECR/COASY/PDK2/PGM1/TPI1 24 BP GO:0086001 cardiac muscle cell action potential 10/819 74/18670 0.001411 0.01826 0.01401 ATP2A2/GJA1/GJC1/KCND3/SNTA1/CAV3/ATP1B1/GPD1L/CACNA1C/BIN1 10 BP GO:0034446 substrate adhesion-dependent cell spreading 12/819 100/18670 0.001422 0.01837 0.01409 MYOC/POSTN/FZD7/LAMB1/MEGF9/HSPG2/CIB1/NRP1/ITGB3/HAS2/ITGB1BP1/VAMP3 12 BP GO:0030220 platelet formation 5/819 20/18670 0.001435 0.01844 0.01414 ACTN1/CIB1/MYH9/PTPN11/CASP9 5 BP GO:0046823 negative regulation of nucleocytoplasmic transport 5/819 20/18670 0.001435 0.01844 0.01414 RANGAP1/TXN/ANGPT1/MDFIC/NUP153 5 BP GO:0009060 aerobic respiration 11/819 87/18670 0.001447 0.01851 0.01419 IDH2/ACO2/SDHA/OGDH/HIF1A/NDUFS7/COX5B/SDHB/UQCRC1/CAT/MDH2 11 BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 11/819 87/18670 0.001447 0.01851 0.01419 MYOC/UNC5B/ANGPT1/NTRK2/PIK3R1/HAX1/PDGFA/PIK3CB/TGFB2/JAK2/CAT 11 BP GO:0038127 ERBB signaling pathway 15/819 142/18670 0.00145 0.01851 0.01419 STAM/HIP1R/MYOC/DOK1/SH3GL2/PRKCA/ITGA1/PIK3R1/ARF4/IQGAP1/RASSF2/EFEMP1/SOCS5/TSG101/PTPN11 15 BP GO:0016049 cell growth 36/819 484/18670 0.001469 0.0187 0.01434 ENPP1/KAZALD1/IGFBP7/CRYAB/SH3GL2/PIN1/CXCL12/POSTN/GJA1/TGFBR1/IGFBP1/ADAM15/CIB1/ADNP2/IQGAP1/FBP1/NRP1/SPG11/NDUFS3/TWF2/CAV3/TGFB2/RGS2/WNT11/EXOSC2/MTOR/TSG101/BCL2/MAP2K4/FBLN5/PPP2R1A/NRP2/PHB/CDKN2A/ITGB1/SORBS2 36 BP GO:0097305 response to alcohol 21/819 233/18670 0.001473 0.0187 0.01434 IGFBP7/SPARC/OXCT1/GRAMD1B/ADCY8/TGFBR1/ADCY7/ADAM15/BCL2L1/GSN/EPS8/STAT3/KLF4/RGS2/GRIN2B/BAD/KCNMB1/TNC/CAT/FOXO3/GRIN2A 21 BP GO:0010976 positive regulation of neuron projection development 24/819 281/18670 0.001475 0.0187 0.01434 CREB3L2/CXCL12/GRN/PTK7/NTRK2/PLXND1/PRKD1/HSPA5/DPYSL3/IQGAP1/NRP1/ITGA3/TWF2/FIG4/RAPGEF1/RGS2/PLXNC1/ITGA6/LPAR1/MTOR/FZD1/VLDLR/NCK1/CAMK1 24 BP GO:1905475 regulation of protein localization to membrane 18/819 187/18670 0.001507 0.01906 0.01462 CEMIP/EPHB2/PIK3R1/ITGB2/BCL2L1/CIB1/GPC4/ITGA3/GSN/NMT1/ITGB1BP1/STAC/BAD/BCL2/AP2B1/SPTBN1/EZR/ITGB1 18 BP GO:0106106 cold-induced thermogenesis 15/819 143/18670 0.001556 0.01958 0.01502 NOVA1/ARNTL/IL18R1/ACOT13/GJA1/NR1H2/NR1H3/HADH/EPAS1/GRB10/UCP2/JAK2/IL4R/PER2/ZNF423 15 BP GO:0120161 regulation of cold-induced thermogenesis 15/819 143/18670 0.001556 0.01958 0.01502 NOVA1/ARNTL/IL18R1/ACOT13/GJA1/NR1H2/NR1H3/HADH/EPAS1/GRB10/UCP2/JAK2/IL4R/PER2/ZNF423 15 BP GO:0003281 ventricular septum development 10/819 75/18670 0.001565 0.01961 0.01504 LTBP1/BMP4/PTK7/TGFBR1/FZD2/TGFB2/WNT11/AP2B1/FZD1/SOX4 10 BP GO:0043242 negative regulation of protein complex disassembly 10/819 75/18670 0.001565 0.01961 0.01504 CIB1/TMOD1/CAPZA2/CLEC16A/GSN/TWF2/EPS8/CAMSAP2/SPTBN1/LMOD1 10 BP GO:0001954 positive regulation of cell-matrix adhesion 8/819 51/18670 0.001582 0.01977 0.01516 COL16A1/MYOC/CIB1/IQGAP1/NRP1/THY1/ITGB1BP1/SDC4 8 BP GO:0003206 cardiac chamber morphogenesis 14/819 129/18670 0.001592 0.01982 0.0152 COL11A1/BMP4/TGFBR1/FOXC1/FZD2/TPM1/NRP1/HIF1A/CAV3/TGFB2/WNT11/NRP2/FZD1/SOX4 14 BP GO:0061458 reproductive system development 33/819 434/18670 0.001592 0.01982 0.0152 MAPK3/VDR/MAP3K4/ASB1/STC2/KDM5B/BMP4/GJA1/TGFBR1/FOXC1/NUPR1/HSPA5/ADAM15/BCL2L1/NDUFS6/INHBB/FKBP4/HIF1A/EPAS1/TGFB2/ARRB2/SULF1/ADAM19/SOCS3/ROR2/BCL2/TNC/PTX3/PTPN11/FOXO3/EIF2S2/TMED2/TMF1 33 BP GO:0009132 nucleoside diphosphate metabolic process 16/819 158/18670 0.001598 0.01984 0.01522 NME3/AK1/OGDH/NUPR1/LDHA/FBP1/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 16 BP GO:0034394 protein localization to cell surface 9/819 63/18670 0.001625 0.02013 0.01544 ANGPT1/TM9SF4/PTPRK/GPM6B/CAV3/GPD1L/WNT11/FBLN5/MAP1A 9 BP GO:0006469 negative regulation of protein kinase activity 21/819 235/18670 0.001637 0.02023 0.01552 EPHB2/BMP4/ADARB1/ADAR/KAT2B/WWTR1/CIB1/CAV3/THY1/ITGB1BP1/RGS2/SOCS5/SOCS3/DUSP7/TSG101/HEXIM1/PPP2R1A/CDKN2A/PKN1/GMFG/NCK1 21 BP GO:0061037 negative regulation of cartilage development 6/819 30/18670 0.001683 0.0207 0.01588 GREM1/BMP4/TGFBR1/SNAI2/EFEMP1/WNT11 6 BP GO:1903205 regulation of hydrogen peroxide-induced cell death 6/819 30/18670 0.001683 0.0207 0.01588 PYCR1/TXN/MET/TRAP1/PAWR/FOXO3 6 BP GO:0048002 antigen processing and presentation of peptide antigen 18/819 189/18670 0.001698 0.02084 0.01599 PSMD8/SH3GL2/PSMB7/PSMD1/CAPZA2/PSMB6/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/PSMD3/TAP1/PSMD2/PSMB8/VAMP3/HLA-DPB1 18 BP GO:0003231 cardiac ventricle development 14/819 130/18670 0.001714 0.02095 0.01607 LTBP1/COL11A1/BMP4/PTK7/TGFBR1/FOXC1/FZD2/TPM1/HIF1A/TGFB2/WNT11/AP2B1/FZD1/SOX4 14 BP GO:0006941 striated muscle contraction 17/819 174/18670 0.001714 0.02095 0.01607 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/TPM1/SNTA1/PDE4B/CAV3/ATP1B1/RGS2/STAC/GPD1L/MTOR/CACNA1C/BIN1 17 BP GO:2000736 regulation of stem cell differentiation 13/819 116/18670 0.001726 0.02104 0.01614 PSMD8/LMO2/PSMB7/BMP4/FOXC1/PSMD1/SOX5/PSMB6/STAT3/TGFB2/PSMD3/PSMD2/PSMB8 13 BP GO:0006119 oxidative phosphorylation 15/819 145/18670 0.001787 0.02174 0.01667 NDUFB8/SDHA/NUPR1/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/UQCRC1/COX7A2/NDUFA1/COQ9/NDUFB7 15 BP GO:0006998 nuclear envelope organization 8/819 52/18670 0.001799 0.02174 0.01667 PRKCA/NSFL1C/NUP93/BANF1/ANKLE2/PRKCB/CHMP2A/PPP2R1A 8 BP GO:0035455 response to interferon-alpha 5/819 21/18670 0.001816 0.02174 0.01667 IFIT2/ADAR/GAS6/IFIT3/MX2 5 BP GO:0036344 platelet morphogenesis 5/819 21/18670 0.001816 0.02174 0.01667 ACTN1/CIB1/MYH9/PTPN11/CASP9 5 BP GO:0072010 glomerular epithelium development 5/819 21/18670 0.001816 0.02174 0.01667 BMP4/FOXC1/IQGAP1/PODXL/CD24 5 BP GO:0010257 NADH dehydrogenase complex assembly 9/819 64/18670 0.001819 0.02174 0.01667 NDUFB8/NDUFAF3/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 9 BP GO:0032981 mitochondrial respiratory chain complex I assembly 9/819 64/18670 0.001819 0.02174 0.01667 NDUFB8/NDUFAF3/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 9 BP GO:0046834 lipid phosphorylation 9/819 64/18670 0.001819 0.02174 0.01667 PI4K2A/PIK3R1/PIK3C3/PIK3R2/PIK3CB/SOCS5/SOCS3/PIP5K1A/PIKFYVE 9 BP GO:0060135 maternal process involved in female pregnancy 9/819 64/18670 0.001819 0.02174 0.01667 MAPK3/VDR/STC2/GJA1/ADCY7/ITGA3/RGS2/MTOR/TMED2 9 BP GO:0010256 endomembrane system organization 33/819 438/18670 0.001847 0.02201 0.01688 MAPK3/PI4K2A/MTSS1/STAM/SH3GL2/PRKCA/ATP2A2/NSFL1C/PRKD1/LYST/MYH9/PIK3C3/VPS11/GSN/NUP93/BANF1/CAV3/ANKLE2/TGFB2/PRKCB/CHMP2A/RAB29/TSG101/PLEKHM2/CAMSAP2/PPP2R1A/BIN1/SPTBN1/COG4/AGFG1/LMAN1/TMED2/TMF1 33 BP GO:0019985 translesion synthesis 7/819 41/18670 0.001858 0.02201 0.01688 ISG15/RFC3/TRIM25/RPA3/USP10/POLD2/RCHY1 7 BP GO:0030835 negative regulation of actin filament depolymerization 7/819 41/18670 0.001858 0.02201 0.01688 TMOD1/CAPZA2/GSN/TWF2/EPS8/SPTBN1/LMOD1 7 BP GO:0090317 negative regulation of intracellular protein transport 7/819 41/18670 0.001858 0.02201 0.01688 RANGAP1/TXN/ANGPT1/MDFIC/UBE2J1/ITGB1BP1/LMAN1 7 BP GO:1901605 alpha-amino acid metabolic process 20/819 222/18670 0.001897 0.0222 0.01703 PYCR1/PCBD1/HMGCL/DDAH2/OGDH/QDPR/P4HA1/AUH/CKB/TYR/FAH/SERINC5/GCLM/GART/MTHFD1/CKMT2/ALDH7A1/CRYM/BCAT2/CTPS1 20 BP GO:0001843 neural tube closure 11/819 90/18670 0.001909 0.0222 0.01703 BMP4/PTK7/FZD2/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SDC4/PHACTR4/TMED2 11 BP GO:0014033 neural crest cell differentiation 11/819 90/18670 0.001909 0.0222 0.01703 MAPK3/BMP4/FOXC1/SNAI2/NRP1/HIF1A/NOLC1/HTR2B/EDNRA/NRP2/PHACTR4 11 BP GO:0045778 positive regulation of ossification 11/819 90/18670 0.001909 0.0222 0.01703 ISG15/BMP4/CLIC1/PRKD1/FBN2/TFAP2A/GPM6B/DDR2/TGFB2/IL6ST/PDLIM7 11 BP GO:0051924 regulation of calcium ion transport 22/819 254/18670 0.001911 0.0222 0.01703 GSTO1/CLIC2/STC2/CEMIP/CXCL12/GJA1/HSPA2/MYLK/MYO5A/PDE4B/GNB5/DIAPH1/CCR1/CAV3/THY1/ATP1B1/ARRB2/STAC/BCL2/CACNA1C/BIN1/TRPC6 22 BP GO:0010745 negative regulation of macrophage derived foam cell differentiation 4/819 13/18670 0.001913 0.0222 0.01703 ABCG1/NR1H2/NR1H3/ITGB3 4 BP GO:0032530 regulation of microvillus organization 4/819 13/18670 0.001913 0.0222 0.01703 PODXL/TWF2/FSCN1/EZR 4 BP GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 4/819 13/18670 0.001913 0.0222 0.01703 PLXND1/NRP1/PLXNC1/NRP2 4 BP GO:0048678 response to axon injury 10/819 77/18670 0.001915 0.0222 0.01703 RANGAP1/GRN/GAP43/ARF4/DPYSL3/NREP/KLF4/JAK2/BCL2/TNC 10 BP GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 10/819 77/18670 0.001915 0.0222 0.01703 PSMD8/PSMB7/PSMD1/HIF1A/PSMB6/EPAS1/PSMD3/PSMD2/PSMB8/CREBBP 10 BP GO:0006986 response to unfolded protein 17/819 176/18670 0.001938 0.02243 0.0172 THBS4/STC2/THBS1/CREB3L2/KDELR3/SERPINH1/COMP/ATP6V0D1/PIK3R1/IGFBP1/HSPA5/HSPA2/GOSR2/DNAJB5/MBTPS1/CTDSP2/NCK1 17 BP GO:0072175 epithelial tube formation 14/819 132/18670 0.001982 0.02285 0.01752 BMP4/PTK7/FZD2/HIF1A/PODXL/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SOX4/SDC4/PHACTR4/TMED2 14 BP GO:0045666 positive regulation of neuron differentiation 29/819 371/18670 0.001983 0.02285 0.01752 CREB3L2/CXCL12/MMD/GRN/BMP4/TGIF2/PTK7/NTRK2/PLXND1/PRKD1/HSPA5/DPYSL3/IQGAP1/NRP1/ITGA3/TWF2/FIG4/RAPGEF1/RGS2/PLXNC1/ITGA6/LPAR1/MTOR/BCL2/FZD1/TRPC6/VLDLR/NCK1/CAMK1 29 BP GO:0014812 muscle cell migration 12/819 104/18670 0.001996 0.02295 0.0176 THBS4/POSTN/TPM1/IQGAP1/NRP1/ITGB3/HAS2/PDGFA/ITGB1BP1/LPAR1/BCL2/ITGA2 12 BP GO:0007568 aging 26/819 321/18670 0.002034 0.02334 0.0179 MAPK3/ARNTL/CTSC/CRYAB/COMP/IGFBP1/ITGB2/NDUFS6/SMC5/GSN/LOXL2/GCLM/STAT3/GPX4/TERF2/MTOR/KCNMB1/BCL2/COL4A2/CAT/TRPC6/PAWR/CASP9/FOXO3/HMGA1/CDKN2A 26 BP GO:0071236 cellular response to antibiotic 15/819 147/18670 0.002047 0.0234 0.01795 PYCR1/CYP1B1/ADCY8/TXN/ADCY7/HSPA5/MAP3K5/MET/TRAP1/KLF4/SIGMAR1/KCNMB1/TRPC6/PAWR/FOXO3 15 BP GO:0002793 positive regulation of peptide secretion 24/819 288/18670 0.002048 0.0234 0.01795 MAPK3/NADK/OXCT1/TCF7L2/ADCY8/POSTN/ABCG1/IL1RAP/GJA1/VEGFC/TNFRSF14/MYRIP/HIF1A/CD2AP/KCNN4/TGFB2/JAK2/IL4R/UNC13B/BAD/HTR2B/SPTBN1/SOX4/EZR 24 BP GO:0060606 tube closure 11/819 91/18670 0.002088 0.0238 0.01825 BMP4/PTK7/FZD2/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SDC4/PHACTR4/TMED2 11 BP GO:0008306 associative learning 10/819 78/18670 0.002112 0.02403 0.01843 CTNS/CLN3/B4GALT2/NPTX2/HIF1A/MTOR/MAP1A/ASIC1/GRIN2A/ITGB1 10 BP GO:0009914 hormone transport 26/819 322/18670 0.002124 0.02411 0.01849 NADK/ARNTL/KDM5B/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/MYO5A/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4/CRYM/TMF1 26 BP GO:1901031 regulation of response to reactive oxygen species 7/819 42/18670 0.002147 0.02432 0.01865 PYCR1/TXN/MET/TRAP1/FBLN5/PAWR/FOXO3 7 BP GO:0007173 epidermal growth factor receptor signaling pathway 13/819 119/18670 0.002173 0.02457 0.01884 STAM/HIP1R/DOK1/SH3GL2/ITGA1/PIK3R1/ARF4/IQGAP1/RASSF2/EFEMP1/SOCS5/TSG101/PTPN11 13 BP GO:0051701 interaction with host 19/819 209/18670 0.002195 0.02477 0.01899 CD55/THOC1/SLC1A5/BCL2L1/TRIM25/TNFRSF14/IFIT1/MET/ITGB3/GSN/NUP153/GAS6/CHMP2A/TSG101/BAD/ITGA2/PTX3/KPNA3/ITGB1 19 BP GO:0033673 negative regulation of kinase activity 22/819 257/18670 0.002213 0.02492 0.01911 EPHB2/BMP4/ADARB1/ADAR/KAT2B/PIK3IP1/WWTR1/CIB1/CAV3/THY1/ITGB1BP1/RGS2/SOCS5/SOCS3/DUSP7/TSG101/HEXIM1/PPP2R1A/CDKN2A/PKN1/GMFG/NCK1 22 BP GO:0051480 regulation of cytosolic calcium ion concentration 28/819 357/18670 0.002238 0.02515 0.01929 GSTO1/CD55/CLIC2/FPR1/CEMIP/CLN3/ADCY8/CCRL2/GJA1/TGM2/MYO5A/CCR3/DIAPH1/ITPR3/CCR1/CD24/CAV3/THY1/JAK2/GRIN2B/LPAR1/BCL2/PLCB1/CACNA1C/HTR2B/EDNRA/TRPC6/GRIN2A 28 BP GO:1901880 negative regulation of protein depolymerization 9/819 66/18670 0.002262 0.0253 0.0194 CIB1/TMOD1/CAPZA2/GSN/TWF2/EPS8/CAMSAP2/SPTBN1/LMOD1 9 BP GO:1905207 regulation of cardiocyte differentiation 9/819 66/18670 0.002262 0.0253 0.0194 GREM1/PIN1/FZD7/BMP4/CAV3/TGFB2/ARRB2/RGS2/MTOR 9 BP GO:0060390 regulation of SMAD protein signal transduction 5/819 22/18670 0.002266 0.0253 0.0194 BMP4/TGFBR1/WWTR1/NUP93/SPTBN1 5 BP GO:0006165 nucleoside diphosphate phosphorylation 14/819 134/18670 0.002283 0.02533 0.01943 NME3/AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 14 BP GO:0032273 positive regulation of protein polymerization 14/819 134/18670 0.002283 0.02533 0.01943 HIP1R/CDC42EP1/MET/ARPC1B/GSN/ARL2/CAV3/CLIP1/MTOR/BIN1/GMFG/RHOBTB2/LMOD1/NCK1 14 BP GO:0032355 response to estradiol 14/819 134/18670 0.002283 0.02533 0.01943 CRYAB/POSTN/RAMP2/COL1A1/GJA1/MBD4/ARPC1B/STAT3/GPX4/BAD/ITGA2/STRN3/CAT/CASP9 14 BP GO:0030042 actin filament depolymerization 8/819 54/18670 0.002303 0.02545 0.01952 MICAL2/TMOD1/CAPZA2/GSN/TWF2/EPS8/SPTBN1/LMOD1 8 BP GO:0061005 cell differentiation involved in kidney development 8/819 54/18670 0.002303 0.02545 0.01952 MTSS1/BMP4/WWTR1/IQGAP1/PODXL/CD24/ACTA2/PRKX 8 BP GO:0009612 response to mechanical stimulus 19/819 210/18670 0.002317 0.02548 0.01955 MAPK3/COL3A1/THBS1/COL11A1/CXCL12/POSTN/COL1A1/GJA1/HABP4/CAV3/WNT11/BAD/MAP2K4/TNC/CLCN6/ITGA2/CHI3L1/PTPN11/XPC 19 BP GO:0048771 tissue remodeling 17/819 179/18670 0.00232 0.02548 0.01955 BGN/VDR/GREM1/THBS4/PLEKHM1/PRKCA/GJA1/FOXC1/TGM2/ABR/RASSF2/HIF1A/ITGB3/LIPA/EPAS1/TNFRSF11B/TCIRG1 17 BP GO:2001235 positive regulation of apoptotic signaling pathway 17/819 179/18670 0.00232 0.02548 0.01955 CTSC/HIP1R/NACC2/THBS1/MAGED1/HRK/TGFBR1/NUPR1/BCL2L1/INHBB/GSN/NMT1/JAK2/BAD/BCL2/PPP2R1A/NCK1 17 BP GO:0003014 renal system process 13/819 120/18670 0.002342 0.02567 0.01969 PCSK5/ADCY8/BMP4/GJA1/CLDN4/ADCY7/ITGA3/HAS2/GSN/SULF1/GAS6/BCL2/PKN1 13 BP GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 7/819 43/18670 0.002469 0.02701 0.02072 CYP1B1/MAP3K5/HIF1A/TRAP1/PDK1/JAK2/BCL2 7 BP GO:1903391 regulation of adherens junction organization 9/819 67/18670 0.002514 0.02745 0.02105 COL16A1/THBS1/MYOC/IQGAP1/NRP1/GPM6B/THY1/ITGB1BP1/SDC4 9 BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 13/819 121/18670 0.002521 0.02747 0.02107 PSMD8/PSMB7/PSMD1/HSPA5/HIF1A/PSMB6/EPAS1/PSMD3/HSF4/PSMD2/PSMB8/CREBBP/NCK1 13 BP GO:0001763 morphogenesis of a branching structure 18/819 196/18670 0.002536 0.02758 0.02115 VDR/KDM5B/MAGED1/BMP4/PLXND1/TGM2/SNAI2/NRP1/MET/PDGFA/COL4A1/CAV3/SULF1/LAMA1/SOCS3/BCL2/TNC/EDNRA 18 BP GO:0048524 positive regulation of viral process 12/819 107/18670 0.002541 0.02759 0.02116 POLR2L/POLR2E/RAD23A/ADARB1/ADAR/MDFIC/IFIT1/PPIB/SUPT4H1/CHMP2A/CHD1/TSG101 12 BP GO:0006888 ER to Golgi vesicle-mediated transport 19/819 212/18670 0.002579 0.02763 0.02119 CD55/CTSC/CREB3L2/KDELR3/RAB33A/ARF4/GOSR2/CAPZA2/NAPA/DYNC1I1/COL7A1/GAS6/ARFGAP2/SEC13/SEC23B/SPTBN1/COG4/LMAN1/TMED2 19 BP GO:0010421 hydrogen peroxide-mediated programmed cell death 4/819 14/18670 0.002586 0.02763 0.02119 MET/TRAP1/PAWR/FOXO3 4 BP GO:0020027 hemoglobin metabolic process 4/819 14/18670 0.002586 0.02763 0.02119 HIF1A/PRMT1/KLF4/CAT 4 BP GO:0030207 chondroitin sulfate catabolic process 4/819 14/18670 0.002586 0.02763 0.02119 BGN/IDS/VCAN/NCAN 4 BP GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 4/819 14/18670 0.002586 0.02763 0.02119 PIK3C3/FIG4/PIK3CB/PIKFYVE 4 BP GO:0097468 programmed cell death in response to reactive oxygen species 4/819 14/18670 0.002586 0.02763 0.02119 MET/TRAP1/PAWR/FOXO3 4 BP GO:1904263 positive regulation of TORC1 signaling 4/819 14/18670 0.002586 0.02763 0.02119 RRAGD/LAMTOR5/CLEC16A/SEC13 4 BP GO:2001044 regulation of integrin-mediated signaling pathway 4/819 14/18670 0.002586 0.02763 0.02119 PRKD1/BST1/ITGB1BP1/PHACTR4 4 BP GO:0070838 divalent metal ion transport 35/819 483/18670 0.002612 0.02786 0.02136 VDR/GSTO1/CLIC2/STC2/CEMIP/CXCL12/ATP2A2/RAMP2/GJA1/HSPA2/MYLK/MYO5A/PDE4B/GNB5/DIAPH1/ITPR3/CCR1/KCNN4/CAV3/THY1/ATP1B1/ARRB2/STAC/GAS6/GRIN2B/PRKCB/BCL2/PLCB1/CACNA1C/HTR2B/BIN1/PHB/ASIC1/TRPC6/GRIN2A 35 BP GO:0007265 Ras protein signal transduction 33/819 448/18670 0.002644 0.02814 0.02158 COL3A1/COL1A2/MYOC/DOK1/EPHB2/RAB32/ARHGEF17/RAB33A/PRKD1/MCF2L/CDC42EP1/RAB27B/ABR/FBP1/NRP1/MET/ITGA3/EPS8/RAPGEF1/ARHGEF15/TGFB2/RASA1/JAK2/RAB8A/LPAR1/RAB29/CYTH1/CTNNAL1/RAB28/PHACTR4/CDKN2A/RHOBTB2/ITGB1 33 BP GO:0002244 hematopoietic progenitor cell differentiation 16/819 166/18670 0.002652 0.02816 0.0216 PSMD8/LMO2/PSMB7/BMP4/FOXC1/ADAR/PSMD1/PSMB6/RRS1/WDR7/BCL2/PSMD3/SOX4/EML1/PSMD2/PSMB8 16 BP GO:0048608 reproductive structure development 32/819 431/18670 0.002697 0.02859 0.02192 MAPK3/VDR/MAP3K4/ASB1/STC2/KDM5B/BMP4/GJA1/TGFBR1/FOXC1/NUPR1/HSPA5/ADAM15/BCL2L1/INHBB/FKBP4/HIF1A/EPAS1/TGFB2/ARRB2/SULF1/ADAM19/SOCS3/ROR2/BCL2/TNC/PTX3/PTPN11/FOXO3/EIF2S2/TMED2/TMF1 32 BP GO:1990778 protein localization to cell periphery 25/819 311/18670 0.002715 0.02873 0.02203 RAMP2/EPHB2/PIK3R1/BCL2L1/CIB1/MYO5A/GPC4/ITGA3/CAV3/PALM/ATP1B1/ITGB1BP1/STAC/GAS6/RAB8A/CLIP1/RAB29/KRT18/PIP5K1A/SPTBN1/EZR/GRIN2A/VAMP3/TMED2/ITGB1 25 BP GO:0043254 regulation of protein complex assembly 34/819 467/18670 0.00277 0.02925 0.02243 HIP1R/CRYAB/VPS41/HRK/ELN/CDC42EP1/VPS11/TMOD1/CAPZA2/FKBP4/HAX1/MET/NAPA/RPA3/ARPC1B/GSN/TWF2/FSCN1/EPS8/ARL2/MAPRE3/CAV3/RASA1/CLIP1/MTOR/UNC13B/CAMSAP2/BIN1/SPTBN1/PTPN11/GMFG/RHOBTB2/LMOD1/NCK1 34 BP GO:0019915 lipid storage 9/819 68/18670 0.002787 0.02925 0.02243 ENPP1/ABCG1/ABHD5/NR1H2/GM2A/NR1H3/MEST/ITGB3/PNPLA2 9 BP GO:0032331 negative regulation of chondrocyte differentiation 5/819 23/18670 0.002792 0.02925 0.02243 GREM1/BMP4/TGFBR1/SNAI2/EFEMP1 5 BP GO:0010837 regulation of keratinocyte proliferation 6/819 33/18670 0.002807 0.02925 0.02243 VDR/PRKD1/SNAI2/HAS2/PTPRK/ZFP36 6 BP GO:2001024 negative regulation of response to drug 6/819 33/18670 0.002807 0.02925 0.02243 PYCR1/TXN/MET/TRAP1/RGS2/PTPN11 6 BP GO:2001038 regulation of cellular response to drug 6/819 33/18670 0.002807 0.02925 0.02243 PYCR1/TXN/MET/TRAP1/PAWR/FOXO3 6 BP GO:0035307 positive regulation of protein dephosphorylation 7/819 44/18670 0.002827 0.02925 0.02243 PPP1R7/PIN1/ITGA1/ANKLE2/JAK2/MTOR/PPP2R5D 7 BP GO:0051489 regulation of filopodium assembly 7/819 44/18670 0.002827 0.02925 0.02243 GAP43/TGFBR1/MYO10/DPYSL3/NRP1/FSCN1/PALM 7 BP GO:0060412 ventricular septum morphogenesis 7/819 44/18670 0.002827 0.02925 0.02243 BMP4/TGFBR1/FZD2/TGFB2/WNT11/FZD1/SOX4 7 BP GO:0031099 regeneration 18/819 198/18670 0.002831 0.02925 0.02243 CXCL12/POSTN/FZD7/GRN/GAP43/GJA1/IGFBP1/ADAM15/NREP/GSN/ANXA3/THY1/KLF4/JAK2/GAS6/SGCA/BCL2/TNC 18 BP GO:0034612 response to tumor necrosis factor 25/819 312/18670 0.002833 0.02925 0.02243 MAPK3/THBS1/PSMD8/PSMB7/POSTN/COL1A1/CD70/PSMD1/CIB1/TNFRSF14/MAP3K5/PSMB6/HAS2/JAK2/GAS6/ZFP36/TNFRSF17/ASAH1/TNFRSF11B/CHI3L1/KRT18/PSMD3/FOXO3/PSMD2/PSMB8 25 BP GO:0046879 hormone secretion 25/819 312/18670 0.002833 0.02925 0.02243 NADK/ARNTL/KDM5B/OXCT1/TCF7L2/PRKCA/ADCY8/RFX3/GJA1/INHBB/MYRIP/HADH/MYO5A/HIF1A/ITPR3/ARL2/JAK2/BAD/ENSA/CACNA1C/TCIRG1/PTPN11/PER2/SOX4/TMF1 25 BP GO:0000187 activation of MAPK activity 15/819 152/18670 0.002835 0.02925 0.02243 MAPK3/MAPKAPK3/FPR1/THBS1/ITGA1/MDFIC/GHR/MAP3K5/MAP4K2/PIK3CB/DUSP7/LPAR1/MAP2K4/PTPN11/PKN1 15 BP GO:0032984 protein-containing complex disassembly 26/819 329/18670 0.002849 0.02934 0.0225 MICAL2/CLN3/SH3GL2/MRPL40/CIB1/FZD2/TMOD1/CAPZA2/CLEC16A/NAPA/GSN/TWF2/MRPL28/EPS8/CHMP2A/TSG101/CAMSAP2/SPTBN1/FZD1/MAP1A/KIF2C/SMARCE1/MAP1LC3B/CKAP5/HMGA1/LMOD1 26 BP GO:0009743 response to carbohydrate 20/819 230/18670 0.002868 0.02943 0.02257 NADK/THBS1/SPARC/OXCT1/TCF7L2/ADCY8/GJA1/LDHA/HIF1A/GCLM/GAS6/PRKCB/UNC13B/BAD/MAP2K4/ENSA/ITGA2/CAT/FOXO3/SOX4 20 BP GO:1904018 positive regulation of vasculature development 20/819 230/18670 0.002868 0.02943 0.02257 THBS1/CYP1B1/PRKCA/RAMP2/ADAM12/GRN/VEGFC/PRKD1/ITGB2/SASH1/CIB1/NRP1/CCR3/HIF1A/ANXA3/STAT3/KLF4/PRKCB/CHI3L1/ITGB1 20 BP GO:0086002 cardiac muscle cell action potential involved in contraction 8/819 56/18670 0.002911 0.02972 0.0228 GJA1/GJC1/KCND3/SNTA1/CAV3/GPD1L/CACNA1C/BIN1 8 BP GO:1903078 positive regulation of protein localization to plasma membrane 8/819 56/18670 0.002911 0.02972 0.0228 EPHB2/PIK3R1/CIB1/ITGA3/STAC/SPTBN1/EZR/ITGB1 8 BP GO:0042089 cytokine biosynthetic process 13/819 123/18670 0.002913 0.02972 0.0228 PCSK5/ASB1/THBS1/IL1RAP/INHBB/MAST2/UBE2J1/STAT3/KLF4/JAK2/ZFP36/IRF7/PAWR 13 BP GO:0006066 alcohol metabolic process 28/819 364/18670 0.00295 0.03005 0.02304 VDR/SYNJ2/TM7SF2/CYP1B1/SORD/PCBD1/ABCG1/FDXR/ADH1C/LBR/QDPR/CYP3A4/ADH1A/CYP27A1/ADH1B/ASAH1/DPM2/NAAA/INPP5E/PLCB1/SULT2B1/MBTPS1/ALDH2/ALDH1A3/CAT/TPI1/VLDLR/NFYB 28 BP GO:0030048 actin filament-based movement 14/819 138/18670 0.002998 0.03042 0.02333 TPM2/GJA1/GJC1/KCND3/TPM1/MYH9/SNTA1/TMOD1/MYO5A/PDE4B/CAV3/GPD1L/CACNA1C/BIN1 14 BP GO:0048732 gland development 32/819 434/18670 0.002999 0.03042 0.02333 MAPK3/VDR/KDM5B/ACO2/HMGCL/BMP4/OAS2/GJA1/TGFBR1/PHF2/PLXND1/FOXC1/TGM2/QDPR/SNAI2/NRP1/FKBP4/TYR/HIF1A/MET/PDGFA/CAV3/TGFB2/SULF1/LAMA1/JAK2/WNT11/BCL2/TNC/ITGA2/ALDH1A3/HLX 32 BP GO:0060415 muscle tissue morphogenesis 10/819 82/18670 0.00307 0.03107 0.02383 COL3A1/COL11A1/ADARB1/TGFBR1/FOXC1/FZD2/TPM1/MYLK/TGFB2/FZD1 10 BP GO:0030166 proteoglycan biosynthetic process 9/819 69/18670 0.003083 0.03107 0.02383 BGN/NDST1/CHST7/CHSY1/TCF7L2/EXT1/ACAN/VCAN/NCAN 9 BP GO:0086003 cardiac muscle cell contraction 9/819 69/18670 0.003083 0.03107 0.02383 GJA1/GJC1/KCND3/SNTA1/PDE4B/CAV3/GPD1L/CACNA1C/BIN1 9 BP GO:0071214 cellular response to abiotic stimulus 26/819 331/18670 0.003091 0.03107 0.02383 MAPK3/ADIRF/CRYAB/COL1A1/GJA1/PIK3R1/HSPA5/HABP4/BCL2L1/POLE3/SNAI2/MYLK/XRCC6/PTPRK/NMT1/SERPINB6/PALM/WNT11/BAD/MAP2K4/ITGA2/PTPN11/ASIC1/CASP9/XPC/CREBBP 26 BP GO:0104004 cellular response to environmental stimulus 26/819 331/18670 0.003091 0.03107 0.02383 MAPK3/ADIRF/CRYAB/COL1A1/GJA1/PIK3R1/HSPA5/HABP4/BCL2L1/POLE3/SNAI2/MYLK/XRCC6/PTPRK/NMT1/SERPINB6/PALM/WNT11/BAD/MAP2K4/ITGA2/PTPN11/ASIC1/CASP9/XPC/CREBBP 26 BP GO:0001838 embryonic epithelial tube formation 13/819 124/18670 0.003127 0.03132 0.02402 BMP4/PTK7/FZD2/HIF1A/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SOX4/SDC4/PHACTR4/TMED2 13 BP GO:0042107 cytokine metabolic process 13/819 124/18670 0.003127 0.03132 0.02402 PCSK5/ASB1/THBS1/IL1RAP/INHBB/MAST2/UBE2J1/STAT3/KLF4/JAK2/ZFP36/IRF7/PAWR 13 BP GO:0046434 organophosphate catabolic process 21/819 248/18670 0.003133 0.03132 0.02402 ENPP1/PLA2G15/SYNJ2/OGDH/PLA2G4C/NUPR1/MBD4/LDHA/FBP1/PDE4B/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/GPD1L/INPP5E/ENPP2/PGM1/TPI1 21 BP GO:0030100 regulation of endocytosis 23/819 281/18670 0.003145 0.03138 0.02407 SFRP4/GREM1/HIP1R/CD151/SH3GL2/ANGPT1/PRKD1/STON1/NR1H2/NR1H3/ABR/CD2AP/ITGB3/PIK3CB/RAPGEF1/CAV3/ARRB2/GAS6/TSG101/AP2B1/ITGA2/BIN1/PTX3 23 BP GO:0048660 regulation of smooth muscle cell proliferation 16/819 169/18670 0.003172 0.0316 0.02423 THBS1/TCF7L2/BMP4/ELN/IL12A/TGM2/TPM1/ABCC4/XRCC6/MAP3K5/NOTCH3/KLF4/JAK2/MTOR/CNN1/ITGA2 16 BP GO:0072511 divalent inorganic cation transport 35/819 489/18670 0.003188 0.03169 0.0243 VDR/GSTO1/CLIC2/STC2/CEMIP/CXCL12/ATP2A2/RAMP2/GJA1/HSPA2/MYLK/MYO5A/PDE4B/GNB5/DIAPH1/ITPR3/CCR1/KCNN4/CAV3/THY1/ATP1B1/ARRB2/STAC/GAS6/GRIN2B/PRKCB/BCL2/PLCB1/CACNA1C/HTR2B/BIN1/PHB/ASIC1/TRPC6/GRIN2A 35 BP GO:0006090 pyruvate metabolic process 15/819 154/18670 0.003213 0.03175 0.02435 OGDH/HAGH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/PDK2/PGM1/TPI1 15 BP GO:0061025 membrane fusion 15/819 154/18670 0.003213 0.03175 0.02435 VPS41/TBC1D4/FOLR3/FOLR2/NSFL1C/VPS11/GOSR2/NAPA/SPG11/GAS6/RAB8A/TAP1/MX1/MX2/VAMP3 15 BP GO:1990845 adaptive thermogenesis 15/819 154/18670 0.003213 0.03175 0.02435 NOVA1/ARNTL/IL18R1/ACOT13/GJA1/NR1H2/NR1H3/HADH/EPAS1/GRB10/UCP2/JAK2/IL4R/PER2/ZNF423 15 BP GO:0032570 response to progesterone 7/819 45/18670 0.003223 0.03175 0.02435 THBS1/RAMP2/CLDN4/NR1H3/WBP2/TGFB2/BAD 7 BP GO:0035987 endodermal cell differentiation 7/819 45/18670 0.003223 0.03175 0.02435 COL8A1/COL5A2/COL11A1/LAMB1/ITGB2/COL7A1/COL4A2 7 BP GO:0048008 platelet-derived growth factor receptor signaling pathway 8/819 57/18670 0.003259 0.03205 0.02458 HIP1R/IQGAP1/NRP1/LOX/PDGFA/RAPGEF1/JAK2/PTPN11 8 BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 31/819 419/18670 0.003283 0.03212 0.02463 ARNTL/SIAH2/USP5/PSMD8/PSMB7/SEL1L/RAD23A/NSFL1C/PSMD1/HSPA5/TRIM25/WWTR1/UBE2G1/RNF144A/CD2AP/CLEC16A/PSMB6/RMND5A/UBE2J1/ARRB2/SOCS5/IFI27/UBE2E1/FBXL2/ANAPC15/MAP1A/PSMD3/RYBP/RCHY1/PSMD2/PSMB8 31 BP GO:0006099 tricarboxylic acid cycle 6/819 34/18670 0.003284 0.03212 0.02463 IDH2/ACO2/SDHA/OGDH/SDHB/MDH2 6 BP GO:0042558 pteridine-containing compound metabolic process 6/819 34/18670 0.003284 0.03212 0.02463 MTHFD2/PCBD1/FOLR2/QDPR/GART/MTHFD1 6 BP GO:0018105 peptidyl-serine phosphorylation 24/819 299/18670 0.003327 0.03249 0.02491 MAPK3/MAPKAPK3/PRKCA/TXN/STK38L/ANGPT1/NTRK2/TGFBR1/PRKD1/RASSF2/MAST4/HAX1/MAST2/ARRB2/GAS6/PRKCB/GPD1L/MTOR/BCL2/PKN1/DYRK1B/PRKX/NCK1/CAMK1 24 BP GO:0045471 response to ethanol 13/819 125/18670 0.003354 0.03266 0.02504 SPARC/OXCT1/ADCY7/GSN/EPS8/STAT3/RGS2/GRIN2B/BAD/KCNMB1/TNC/CAT/GRIN2A 13 BP GO:1901879 regulation of protein depolymerization 10/819 83/18670 0.003357 0.03266 0.02504 CIB1/TMOD1/CAPZA2/GSN/TWF2/EPS8/CAMSAP2/SPTBN1/MAP1A/LMOD1 10 BP GO:0009110 vitamin biosynthetic process 5/819 24/18670 0.003401 0.03277 0.02513 VDR/SNAI2/CYP3A4/CYP27A1/PLTP 5 BP GO:0032528 microvillus organization 5/819 24/18670 0.003401 0.03277 0.02513 PODXL/TWF2/FSCN1/PTPN11/EZR 5 BP GO:0045606 positive regulation of epidermal cell differentiation 5/819 24/18670 0.003401 0.03277 0.02513 SFRP4/VDR/BMP4/FOXC1/SULT2B1 5 BP GO:0042559 pteridine-containing compound biosynthetic process 4/819 15/18670 0.003405 0.03277 0.02513 PCBD1/QDPR/GART/MTHFD1 4 BP GO:0048569 post-embryonic animal organ development 4/819 15/18670 0.003405 0.03277 0.02513 LDHA/EFEMP1/KLF4/HMGN1 4 BP GO:1903543 positive regulation of exosomal secretion 4/819 15/18670 0.003405 0.03277 0.02513 STAM/CHMP2A/TSG101/SDC4 4 BP GO:0071453 cellular response to oxygen levels 20/819 234/18670 0.003492 0.03355 0.02573 STC2/PSMD8/PSMB7/ATP6V0D1/PSMD1/HIF1A/PSMB6/EPAS1/PDK1/LPAR1/MTOR/BAD/KCNMB1/BCL2/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 20 BP GO:0050769 positive regulation of neurogenesis 34/819 474/18670 0.003501 0.03358 0.02575 CREB3L2/CXCL12/MMD/EPHB2/GRN/BMP4/TGIF2/PTK7/NTRK2/PLXND1/VEGFC/PRKD1/HSPA5/DPYSL3/IQGAP1/NRP1/HIF1A/ITGA3/TWF2/FIG4/RAPGEF1/RGS2/PLXNC1/ITGA6/IL6ST/LPAR1/MTOR/BCL2/BIN1/FZD1/TRPC6/VLDLR/NCK1/CAMK1 34 BP GO:0016241 regulation of macroautophagy 16/819 171/18670 0.003564 0.034 0.02608 MAPK3/ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/RRAGD/NUPR1/ATP6V0C/LAMTOR5/ATP6V1H/HIF1A/CLEC16A/CAPNS1/MTOR/ATP6V1D/PIKFYVE 16 BP GO:0048659 smooth muscle cell proliferation 16/819 171/18670 0.003564 0.034 0.02608 THBS1/TCF7L2/BMP4/ELN/IL12A/TGM2/TPM1/ABCC4/XRCC6/MAP3K5/NOTCH3/KLF4/JAK2/MTOR/CNN1/ITGA2 16 BP GO:0006909 phagocytosis 28/819 369/18670 0.00357 0.034 0.02608 MAPK3/THBS1/PIK3R1/TGM2/ITGB2/MYO10/NR1H3/TM9SF4/ABR/MYH9/GULP1/MET/ITGB3/SPG11/ARPC1B/GSN/ANXA3/PIK3R2/PIK3CB/RAPGEF1/GAS6/IGLL1/ITGA2/PIP5K1A/PTX3/RHOBTB2/NCK1/ITGB1 28 BP GO:0035690 cellular response to drug 28/819 369/18670 0.00357 0.034 0.02608 MAPK3/PYCR1/ADIRF/CYP1B1/ADCY8/TXN/FOLR2/ADCY7/HSPA5/ADAM15/QDPR/FBP1/MAP3K5/PDE4B/MET/TRAP1/GCLM/KLF4/GAS6/P2RY2/SIGMAR1/BAD/KCNMB1/PLCB1/TRPC6/PAWR/CASP9/FOXO3 28 BP GO:0045637 regulation of myeloid cell differentiation 21/819 251/18670 0.003607 0.03429 0.0263 THBS1/PRKCA/ISG15/PIK3R1/KAT2B/CIB1/RASSF2/LOX/HAX1/TNRC6B/HIF1A/PRMT1/CCR1/STAT3/ZFP36/PRKCB/MTOR/IRF7/ROR2/FOXO3/CREBBP 21 BP GO:0030837 negative regulation of actin filament polymerization 8/819 58/18670 0.003639 0.03432 0.02632 HIP1R/TMOD1/CAPZA2/GSN/TWF2/EPS8/SPTBN1/LMOD1 8 BP GO:0035306 positive regulation of dephosphorylation 8/819 58/18670 0.003639 0.03432 0.02632 PPP1R7/PIN1/ITGA1/ANKLE2/JAK2/MTOR/ITGA2/PPP2R5D 8 BP GO:0035904 aorta development 8/819 58/18670 0.003639 0.03432 0.02632 COL3A1/LTBP1/PLXND1/MYLK/LOX/TGFB2/AP2B1/SOX4 8 BP GO:0010883 regulation of lipid storage 7/819 46/18670 0.003661 0.03432 0.02632 ABCG1/ABHD5/NR1H2/NR1H3/MEST/ITGB3/PNPLA2 7 BP GO:0033628 regulation of cell adhesion mediated by integrin 7/819 46/18670 0.003661 0.03432 0.02632 CYP1B1/CIB1/SNAI2/PODXL/TGFB2/ITGB1BP1/PTPN11 7 BP GO:0043277 apoptotic cell clearance 7/819 46/18670 0.003661 0.03432 0.02632 THBS1/TGM2/NR1H3/ITGB3/SPG11/GAS6/RHOBTB2 7 BP GO:0071675 regulation of mononuclear cell migration 7/819 46/18670 0.003661 0.03432 0.02632 MAPK3/GREM1/RARRES2/THBS1/CXCL12/CCR1/PLCB1 7 BP GO:1904036 negative regulation of epithelial cell apoptotic process 7/819 46/18670 0.003661 0.03432 0.02632 TCF7L2/RAMP2/ANGPT1/SCG2/NUPR1/GAS6/MTOR 7 BP GO:0043583 ear development 19/819 219/18670 0.003696 0.03459 0.02653 MAPK3/LRIG1/SPARC/COL11A1/NAGLU/EPHB2/BMP4/PTK7/FZD2/ABR/TFAP2A/FZD6/MPV17/TGFB2/ROR2/BCL2/ALDH1A3/PTPN11/SDC4 19 BP GO:0000041 transition metal ion transport 12/819 112/18670 0.003715 0.03465 0.02657 ATP6V0E2/SLC31A2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATOX1/ATP6V0C/ATP6V1H/FKBP4/TCIRG1/ATP6V1D/TRPC6 12 BP GO:0031109 microtubule polymerization or depolymerization 12/819 112/18670 0.003715 0.03465 0.02657 CRYAB/CIB1/FKBP4/MET/ARL2/MAPRE3/CAV3/CLIP1/CAMSAP2/MAP1A/KIF2C/CKAP5 12 BP GO:0051348 negative regulation of transferase activity 23/819 285/18670 0.003745 0.03487 0.02674 EPHB2/BMP4/ADARB1/ADAR/KAT2B/PIK3IP1/WWTR1/CIB1/CAV3/THY1/ITGB1BP1/RGS2/ZFP36/SOCS5/SOCS3/DUSP7/TSG101/HEXIM1/PPP2R1A/CDKN2A/PKN1/GMFG/NCK1 23 BP GO:0043473 pigmentation 11/819 98/18670 0.003751 0.03487 0.02674 ENPP1/SPARC/HPS1/RAB32/RAB27B/LYST/SNAI2/MYO5A/TYR/FIG4/BCL2 11 BP GO:0006101 citrate metabolic process 6/819 35/18670 0.003819 0.03544 0.02718 IDH2/ACO2/SDHA/OGDH/SDHB/MDH2 6 BP GO:0043620 regulation of DNA-templated transcription in response to stress 13/819 127/18670 0.003848 0.03564 0.02734 PSMD8/PSMB7/PSMD1/HSPA5/HIF1A/PSMB6/EPAS1/PSMD3/HSF4/PSMD2/PSMB8/CREBBP/NCK1 13 BP GO:0010498 proteasomal protein catabolic process 34/819 477/18670 0.003862 0.03571 0.02739 ARNTL/SIAH2/USP5/PSMD8/PSMB7/SEL1L/RAD23A/NSFL1C/NUPR1/PSMD1/HSPA5/TRIM25/WWTR1/ENC1/UBE2G1/RNF144A/CD2AP/CLEC16A/PSMB6/RMND5A/UBE2J1/ARRB2/SOCS5/IFI27/UBE2E1/FBXL2/ANAPC15/MAP1A/PSMD3/RYBP/RCHY1/PSMD2/PSMB8/TMF1 34 BP GO:0035265 organ growth 18/819 204/18670 0.003892 0.03593 0.02756 PIN1/COMP/GJA1/TGFBR1/FOXC1/COL14A1/COL6A3/COL7A1/CAV3/DDR2/TGFB2/RGS2/MTOR/BCL2/MAP2K4/PTPN11/HLX/SORBS2 18 BP GO:0001659 temperature homeostasis 16/819 173/18670 0.003995 0.0367 0.02815 NOVA1/ARNTL/IL18R1/ACOT13/GJA1/NR1H2/NR1H3/HADH/EPAS1/GRB10/STAT3/UCP2/JAK2/IL4R/PER2/ZNF423 16 BP GO:0003018 vascular process in circulatory system 16/819 173/18670 0.003995 0.0367 0.02815 RAMP2/ITGA1/COMP/ANGPT1/GJA1/FOXC1/ABR/GCLM/ITGB1BP1/RGS2/P2RY2/KCNMB1/HTR2B/EDNRA/ACTA2/PER2 16 BP GO:0055002 striated muscle cell development 16/819 173/18670 0.003995 0.0367 0.02815 PIN1/COMP/BMP4/MAML1/TPM1/CSRP2/TMOD1/LOX/CAV3/RGS2/MTOR/BCL2/MAP2K4/LMOD1/ITGB1/SORBS2 16 BP GO:0031669 cellular response to nutrient levels 20/819 237/18670 0.004031 0.03697 0.02835 MAPK3/VDR/POSTN/COL1A1/RRAGD/FOLR2/PRKD1/HSPA5/PIK3C3/INHBB/SNAI2/MAP3K5/CLEC16A/GAS6/MTOR/P2RY2/BCL2/TNC/PDK2/MAP1LC3B 20 BP GO:0031102 neuron projection regeneration 8/819 59/18670 0.004051 0.03702 0.02839 GRN/GAP43/NREP/THY1/KLF4/JAK2/BCL2/TNC 8 BP GO:0045071 negative regulation of viral genome replication 8/819 59/18670 0.004051 0.03702 0.02839 OAS1/ISG15/IFIT1/BANF1/OASL/RSAD2/APOBEC3C/MX1 8 BP GO:0070301 cellular response to hydrogen peroxide 11/819 99/18670 0.004058 0.03702 0.02839 PYCR1/CYP1B1/TXN/MAP3K5/MET/TRAP1/KLF4/SIGMAR1/TRPC6/PAWR/FOXO3 11 BP GO:0032272 negative regulation of protein polymerization 9/819 72/18670 0.004122 0.03723 0.02855 HIP1R/TMOD1/CAPZA2/FKBP4/GSN/TWF2/EPS8/SPTBN1/LMOD1 9 BP GO:0051155 positive regulation of striated muscle cell differentiation 9/819 72/18670 0.004122 0.03723 0.02855 GREM1/PIN1/BMP4/MAML1/CAV3/ARRB2/IL4R/MTOR/BCL2 9 BP GO:0051881 regulation of mitochondrial membrane potential 9/819 72/18670 0.004122 0.03723 0.02855 PYCR1/CTNS/MYOC/CLIC1/BCL2L1/GCLM/BAD/BCL2/HEBP2 9 BP GO:0061035 regulation of cartilage development 9/819 72/18670 0.004122 0.03723 0.02855 GREM1/BMP1/BMP4/TGFBR1/SOX5/SNAI2/EFEMP1/LOXL2/WNT11 9 BP GO:1902036 regulation of hematopoietic stem cell differentiation 9/819 72/18670 0.004122 0.03723 0.02855 PSMD8/LMO2/PSMB7/FOXC1/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 9 BP GO:0014911 positive regulation of smooth muscle cell migration 7/819 47/18670 0.004142 0.03723 0.02855 POSTN/IQGAP1/NRP1/HAS2/LPAR1/BCL2/ITGA2 7 BP GO:0031952 regulation of protein autophosphorylation 7/819 47/18670 0.004142 0.03723 0.02855 ENPP1/GREM1/VEGFC/IQGAP1/RASSF2/PDGFA/PPP2R5D 7 BP GO:0070849 response to epidermal growth factor 7/819 47/18670 0.004142 0.03723 0.02855 MAPK3/COL1A1/FOXC1/IQGAP1/SNAI2/ZFP36/PTPN11 7 BP GO:0120163 negative regulation of cold-induced thermogenesis 7/819 47/18670 0.004142 0.03723 0.02855 NOVA1/ARNTL/IL18R1/ACOT13/NR1H2/NR1H3/ZNF423 7 BP GO:0023061 signal release 33/819 462/18670 0.004244 0.03808 0.0292 NADK/ARNTL/KDM5B/OXCT1/TCF7L2/PRKCA/ADCY8/ATP2A2/RFX3/PPFIA4/GJA1/SV2A/INHBB/MYRIP/HADH/MYO5A/HIF1A/ITPR3/NAPA/ARL2/JAK2/PRKCB/UNC13B/BAD/NAAA/ENSA/CACNA1C/TCIRG1/PTPN11/ASIC1/PER2/SOX4/TMF1 33 BP GO:0018209 peptidyl-serine modification 25/819 322/18670 0.004266 0.03822 0.02931 MAPK3/BGN/MAPKAPK3/PRKCA/TXN/STK38L/ANGPT1/NTRK2/TGFBR1/PRKD1/RASSF2/MAST4/HAX1/MAST2/ARRB2/GAS6/PRKCB/GPD1L/MTOR/BCL2/PKN1/DYRK1B/PRKX/NCK1/CAMK1 25 BP GO:0022409 positive regulation of cell-cell adhesion 21/819 255/18670 0.00433 0.03873 0.0297 CD55/PIK3R1/CD70/IL12A/ITGB2/MYO10/TNFRSF14/PODXL/HAS2/CD24/THY1/ADAM19/ITGA6/SOCS5/IL6ST/IL4R/BAD/PTPN11/NCK1/HLX/HLA-DPB1 21 BP GO:0048013 ephrin receptor signaling pathway 10/819 86/18670 0.004346 0.03873 0.0297 EPHB2/EPHB4/CHN1/ARPC1B/RASA1/GRIN2B/AP2B1/EPHB6/PTPN11/NCK1 10 BP GO:0044282 small molecule catabolic process 32/819 445/18670 0.004365 0.03873 0.0297 RENBP/PLA2G15/SYNJ2/ECI1/CEMIP/OXCT1/PCCB/SORD/PCBD1/HMGCL/DDAH2/APOBEC3B/OGDH/HAGH/QDPR/AUH/HADH/CYP27A1/FAH/PEX7/APOBEC3C/GNPDA1/MTOR/BAD/ETFB/INPP5E/ALDH2/PGM1/TPI1/ALDH7A1/CRYM/BCAT2 32 BP GO:2001023 regulation of response to drug 11/819 100/18670 0.004383 0.03873 0.0297 PYCR1/ADIRF/CXCL12/TXN/MET/TRAP1/RGS2/PTPN11/PER2/PAWR/FOXO3 11 BP GO:0010875 positive regulation of cholesterol efflux 4/819 16/18670 0.004384 0.03873 0.0297 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0055119 relaxation of cardiac muscle 4/819 16/18670 0.004384 0.03873 0.0297 ATP2A2/PDE4B/ATP1B1/RGS2 4 BP GO:0070293 renal absorption 4/819 16/18670 0.004384 0.03873 0.0297 CLDN4/HAS2/GSN/GAS6 4 BP GO:1903541 regulation of exosomal secretion 4/819 16/18670 0.004384 0.03873 0.0297 STAM/CHMP2A/TSG101/SDC4 4 BP GO:0010975 regulation of neuron projection development 35/819 499/18670 0.004387 0.03873 0.0297 CREB3L2/TRAK2/CXCL12/EPHB2/GRN/PTK7/NTRK2/PLXND1/PRKD1/HSPA5/CIB1/DPYSL3/IQGAP1/NRP1/FKBP4/ITGA3/CHN1/TWF2/FIG4/RAPGEF1/THY1/PMP22/KLF4/RGS2/PLXNC1/ITGA6/LPAR1/MTOR/RAB29/CAMSAP2/FZD1/TRPC6/VLDLR/NCK1/CAMK1 35 BP GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway 6/819 36/18670 0.004416 0.03892 0.02985 EMILIN1/VEGFC/HIF1A/ITGB3/GRB10/PRKCB 6 BP GO:0032103 positive regulation of response to external stimulus 25/819 323/18670 0.004438 0.03906 0.02995 MAPK3/RARRES2/THBS4/CTSC/THBS1/PRKCA/CXCL12/GRN/SCG2/VEGFC/PRKD1/NUPR1/IL12A/TGM2/SASH1/NRP1/MET/OSMR/CCR1/JAK2/GAS6/IL6ST/LPAR1/UNC13B/ITGA2 25 BP GO:0044766 multi-organism transport 9/819 73/18670 0.004524 0.03945 0.03026 THOC1/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/KPNA3 9 BP GO:1902579 multi-organism localization 9/819 73/18670 0.004524 0.03945 0.03026 THOC1/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/KPNA3 9 BP GO:0001819 positive regulation of cytokine production 33/819 464/18670 0.004528 0.03945 0.03026 MAPK3/IL18R1/POLR2L/THBS1/CYP1B1/POLR2E/POSTN/IL1RAP/PIK3R1/IL12A/TNFRSF14/LRRFIP1/POLR3D/XRCC6/PDE4B/HIF1A/POLR3G/STAT3/SULF1/JAK2/RSAD2/IL6ST/WNT11/IL4R/IRF7/PLCB1/AGPAT1/HTR2B/SPTBN1/PTPN11/CREBBP/TMF1/HLA-DPB1 33 BP GO:0042110 T cell activation 33/819 464/18670 0.004528 0.03945 0.03026 CD55/IL18R1/CD151/FZD7/MICB/BMP4/GJA1/PIK3R1/CD70/IL12A/TNFRSF14/MYH9/GSN/CD24/THY1/STAT3/RSAD2/SOCS5/IL6ST/IL4R/MTOR/RAB29/BAD/BCL2/TCIRG1/PTPN11/PAWR/SOX4/SDC4/CTPS1/NCK1/HLX/HLA-DPB1 33 BP GO:0007611 learning or memory 21/819 256/18670 0.004529 0.03945 0.03026 CTNS/ATP8A1/CLN3/ADCY8/EPHB2/NTRK2/B4GALT2/ARF4/GM2A/NPTX2/HIF1A/ITPR3/ITGA3/GRIN2B/MTOR/PLCB1/MAP1A/ASIC1/GRIN2A/VLDLR/ITGB1 21 BP GO:0034284 response to monosaccharide 18/819 207/18670 0.004534 0.03945 0.03026 NADK/THBS1/SPARC/OXCT1/TCF7L2/ADCY8/GJA1/LDHA/HIF1A/GCLM/GAS6/UNC13B/BAD/ENSA/ITGA2/CAT/FOXO3/SOX4 18 BP GO:0071456 cellular response to hypoxia 18/819 207/18670 0.004534 0.03945 0.03026 STC2/PSMD8/PSMB7/PSMD1/HIF1A/PSMB6/EPAS1/PDK1/MTOR/BAD/KCNMB1/BCL2/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 18 BP GO:0006096 glycolytic process 12/819 115/18670 0.004606 0.04001 0.03068 OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 12 BP GO:0007612 learning 14/819 145/18670 0.004687 0.04065 0.03118 CTNS/ATP8A1/CLN3/EPHB2/NTRK2/B4GALT2/ARF4/NPTX2/HIF1A/MTOR/MAP1A/ASIC1/GRIN2A/ITGB1 14 BP GO:0031532 actin cytoskeleton reorganization 11/819 101/18670 0.004729 0.04095 0.03141 PTK7/MYH9/NRP1/HAX1/CD2AP/GSN/EPS8/PIP5K1A/EZR/GMFG/RHOBTB2 11 BP GO:0048839 inner ear development 17/819 192/18670 0.004771 0.04125 0.03163 LRIG1/SPARC/COL11A1/NAGLU/EPHB2/BMP4/PTK7/FZD2/ABR/TFAP2A/FZD6/MPV17/TGFB2/ROR2/ALDH1A3/PTPN11/SDC4 17 BP GO:0030206 chondroitin sulfate biosynthetic process 5/819 26/18670 0.004896 0.04219 0.03236 BGN/CHST7/CHSY1/VCAN/NCAN 5 BP GO:0031954 positive regulation of protein autophosphorylation 5/819 26/18670 0.004896 0.04219 0.03236 GREM1/VEGFC/IQGAP1/RASSF2/PDGFA 5 BP GO:0006757 ATP generation from ADP 12/819 116/18670 0.004938 0.04242 0.03253 OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 12 BP GO:0070252 actin-mediated cell contraction 12/819 116/18670 0.004938 0.04242 0.03253 TPM2/GJA1/GJC1/KCND3/TPM1/SNTA1/TMOD1/PDE4B/CAV3/GPD1L/CACNA1C/BIN1 12 BP GO:0031670 cellular response to nutrient 9/819 74/18670 0.004955 0.04243 0.03254 VDR/POSTN/COL1A1/FOLR2/SNAI2/GAS6/P2RY2/TNC/PDK2 9 BP GO:0032507 maintenance of protein location in cell 9/819 74/18670 0.004955 0.04243 0.03254 KDELR3/RANGAP1/TXN/HSPA5/GSN/TWF2/ARL2/FLNB/EZR 9 BP GO:0035264 multicellular organism growth 14/819 146/18670 0.004982 0.04248 0.03258 STC2/COMP/ADARB1/WWTR1/NDUFS6/GHR/PPIB/STAT3/MTOR/BCL2/KDM6A/PTPN11/EZR/TMED2 14 BP GO:0045123 cellular extravasation 8/819 61/18670 0.004984 0.04248 0.03258 CXCL12/ITGA1/ITGB2/ABR/THY1/BST1/PLCB1/ITGB1 8 BP GO:1905953 negative regulation of lipid localization 8/819 61/18670 0.004984 0.04248 0.03258 THBS1/ABCG1/ABHD5/NR1H2/NR1H3/ITGB3/PNPLA2/PTPN11 8 BP GO:0046887 positive regulation of hormone secretion 13/819 131/18670 0.005011 0.04264 0.0327 NADK/OXCT1/TCF7L2/ADCY8/GJA1/INHBB/MYRIP/HIF1A/JAK2/BAD/PTPN11/SOX4/TMF1 13 BP GO:0090287 regulation of cellular response to growth factor stimulus 23/819 292/18670 0.005026 0.0427 0.03275 SFRP4/GREM1/THBS1/LTBP1/PIN1/EMILIN1/BMP4/TGFBR1/VEGFC/HSPA5/FBN2/NREP/LOX/HIF1A/ITGB3/ITGA3/GRB10/CAV3/SULF1/PRKCB/FZD1/ZNF423/CREBBP 23 BP GO:0033280 response to vitamin D 6/819 37/18670 0.005078 0.04308 0.03304 VDR/STC2/TRIM25/SNAI2/TYR/TNC 6 BP GO:0048644 muscle organ morphogenesis 10/819 88/18670 0.005125 0.04341 0.03329 COL3A1/COL11A1/ADARB1/TGFBR1/FOXC1/FZD2/TPM1/MYLK/TGFB2/FZD1 10 BP GO:0034404 nucleobase-containing small molecule biosynthetic process 19/819 226/18670 0.005189 0.04389 0.03366 ENPP1/NME3/OGDH/NUPR1/MBD4/LDHA/FBP1/TK2/PDE4B/GUK1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1/CTPS1 19 BP GO:0051146 striated muscle cell differentiation 23/819 293/18670 0.005235 0.04421 0.0339 GREM1/PIN1/FZD7/ADAM12/COMP/BMP4/MAML1/TPM1/MYH9/CSRP2/TMOD1/LOX/CAV3/ARRB2/RGS2/IL4R/MTOR/BCL2/MAP2K4/LMOD1/DYRK1B/ITGB1/SORBS2 23 BP GO:0019359 nicotinamide nucleotide biosynthetic process 14/819 147/18670 0.005291 0.04447 0.0341 NADK/IDH2/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 14 BP GO:0019363 pyridine nucleotide biosynthetic process 14/819 147/18670 0.005291 0.04447 0.0341 NADK/IDH2/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 14 BP GO:0090263 positive regulation of canonical Wnt signaling pathway 14/819 147/18670 0.005291 0.04447 0.0341 SFRP4/ARNTL/PSMD8/PIN1/PSMB7/COL1A1/PTK7/PSMD1/PSMB6/ROR2/PSMD3/SOX4/PSMD2/PSMB8 14 BP GO:0042552 myelination 13/819 132/18670 0.005342 0.04483 0.03438 CTSC/MYOC/NTRK2/PLP1/MYO5A/SERINC5/FIG4/TSPAN2/PMP22/LPAR1/MTOR/PIKFYVE/NAB1 13 BP GO:0072659 protein localization to plasma membrane 21/819 260/18670 0.0054 0.04524 0.0347 RAMP2/EPHB2/PIK3R1/BCL2L1/CIB1/MYO5A/ITGA3/CAV3/PALM/ATP1B1/ITGB1BP1/STAC/GAS6/RAB8A/KRT18/PIP5K1A/SPTBN1/EZR/VAMP3/TMED2/ITGB1 21 BP GO:0001707 mesoderm formation 9/819 75/18670 0.005417 0.04525 0.0347 BMP4/FOXC1/ITGB3/ITGA3/KLF4/WNT11/KDM6A/ITGA2/ITGB1 9 BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 9/819 75/18670 0.005417 0.04525 0.0347 PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/TAP1/PSMD2/PSMB8/VAMP3 9 BP GO:0006089 lactate metabolic process 4/819 17/18670 0.005536 0.04553 0.03492 HAGH/LDHA/HIF1A/PER2 4 BP GO:0006750 glutathione biosynthetic process 4/819 17/18670 0.005536 0.04553 0.03492 GGT5/HAGH/GGCT/GCLM 4 BP GO:0010224 response to UV-B 4/819 17/18670 0.005536 0.04553 0.03492 IL12A/HMGN1/BCL2/XPC 4 BP GO:0021783 preganglionic parasympathetic fiber development 4/819 17/18670 0.005536 0.04553 0.03492 ADARB1/NRP1/TFAP2A/NRP2 4 BP GO:0048532 anatomical structure arrangement 4/819 17/18670 0.005536 0.04553 0.03492 HSPA5/NRP1/TFAP2A/NRP2 4 BP GO:0061318 renal filtration cell differentiation 4/819 17/18670 0.005536 0.04553 0.03492 BMP4/IQGAP1/PODXL/CD24 4 BP GO:0072112 glomerular visceral epithelial cell differentiation 4/819 17/18670 0.005536 0.04553 0.03492 BMP4/IQGAP1/PODXL/CD24 4 BP GO:2000811 negative regulation of anoikis 4/819 17/18670 0.005536 0.04553 0.03492 NTRK2/SNAI2/BCL2/ITGB1 4 BP GO:0006611 protein export from nucleus 16/819 179/18670 0.005551 0.04553 0.03492 THOC1/TCF7L2/RANGAP1/TXN/DDX39A/NUP205/NUP93/NUP153/RRS1/GAS6/SEC13/IFI27/PTPN11/SRSF7/AGFG1/CAMK1 16 BP GO:0030177 positive regulation of Wnt signaling pathway 16/819 179/18670 0.005551 0.04553 0.03492 SFRP4/ARNTL/PSMD8/PIN1/PSMB7/COL1A1/PTK7/PSMD1/ATP6V0C/PSMB6/SULF1/ROR2/PSMD3/SOX4/PSMD2/PSMB8 16 BP GO:0048736 appendage development 16/819 179/18670 0.005551 0.04553 0.03492 GREM1/PCSK5/COMP/BMP4/GJA1/KAT2B/FBN2/TFAP2A/FZD6/TGFB2/ITGA6/IQCE/ROR2/CACNA1C/SOX4/CREBBP 16 BP GO:0060173 limb development 16/819 179/18670 0.005551 0.04553 0.03492 GREM1/PCSK5/COMP/BMP4/GJA1/KAT2B/FBN2/TFAP2A/FZD6/TGFB2/ITGA6/IQCE/ROR2/CACNA1C/SOX4/CREBBP 16 BP GO:0051668 localization within membrane 14/819 148/18670 0.005615 0.04598 0.03527 ITGB2/GPC4/ITGB3/GSN/CD24/THY1/ATP1B1/ITGB1BP1/GLRB/SEC13/RAB8A/CLIP1/AP2B1/SEC23B 14 BP GO:0042471 ear morphogenesis 12/819 118/18670 0.00566 0.04628 0.03549 MAPK3/LRIG1/COL11A1/NAGLU/EPHB2/PTK7/FZD2/ABR/TFAP2A/FZD6/ROR2/ALDH1A3 12 BP GO:0061437 renal system vasculature development 5/819 27/18670 0.005795 0.0471 0.03612 BMP4/ANGPT1/NRP1/NOTCH3/ACTA2 5 BP GO:0061440 kidney vasculature development 5/819 27/18670 0.005795 0.0471 0.03612 BMP4/ANGPT1/NRP1/NOTCH3/ACTA2 5 BP GO:0003298 physiological muscle hypertrophy 6/819 38/18670 0.005812 0.0471 0.03612 PIN1/CAV3/RGS2/MTOR/MAP2K4/SORBS2 6 BP GO:0003301 physiological cardiac muscle hypertrophy 6/819 38/18670 0.005812 0.0471 0.03612 PIN1/CAV3/RGS2/MTOR/MAP2K4/SORBS2 6 BP GO:0061049 cell growth involved in cardiac muscle cell development 6/819 38/18670 0.005812 0.0471 0.03612 PIN1/CAV3/RGS2/MTOR/MAP2K4/SORBS2 6 BP GO:0086005 ventricular cardiac muscle cell action potential 6/819 38/18670 0.005812 0.0471 0.03612 KCND3/SNTA1/CAV3/GPD1L/CACNA1C/BIN1 6 BP GO:0002685 regulation of leukocyte migration 17/819 196/18670 0.005854 0.04733 0.0363 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/EMILIN1/VEGFC/IL12A/ABR/TNFRSF14/CCR1/THY1/BST1/GAS6/PLCB1/ITGA2 17 BP GO:0001706 endoderm formation 7/819 50/18670 0.005875 0.04733 0.0363 COL8A1/COL5A2/COL11A1/LAMB1/ITGB2/COL7A1/COL4A2 7 BP GO:0031113 regulation of microtubule polymerization 7/819 50/18670 0.005875 0.04733 0.0363 FKBP4/MET/ARL2/MAPRE3/CAV3/CLIP1/CAMSAP2 7 BP GO:0070741 response to interleukin-6 7/819 50/18670 0.005875 0.04733 0.0363 STAT3/JAK2/IL6ST/SOCS3/CHI3L1/PTPN11/PHB 7 BP GO:0007492 endoderm development 9/819 76/18670 0.005912 0.04747 0.0364 COL8A1/COL5A2/COL11A1/BMP4/LAMB1/ITGB2/COL7A1/EXT1/COL4A2 9 BP GO:0060411 cardiac septum morphogenesis 9/819 76/18670 0.005912 0.04747 0.0364 BMP4/TGFBR1/FZD2/NRP1/TGFB2/WNT11/NRP2/FZD1/SOX4 9 BP GO:0006631 fatty acid metabolic process 28/819 383/18670 0.005918 0.04747 0.0364 MAPK3/PLA2G15/GGT5/ECI1/CYP1B1/PCCB/LPGAT1/ABHD5/PLA2G4C/ELOVL2/NR1H2/NDUFAB1/NR1H3/PLP1/NDUFS6/AUH/CYP3A4/HADH/MYO5A/GPX4/PDK1/PEX7/MTOR/NAAA/ETFB/TECR/PDK2/PER2 28 BP GO:0010594 regulation of endothelial cell migration 19/819 229/18670 0.005965 0.04778 0.03664 PRCP/THBS1/SPARC/PRKCA/GRN/BMP4/ANGPT1/VEGFC/PRKD1/SASH1/CIB1/NRP1/HIF1A/MET/ITGB3/ANXA3/KLF4/ITGB1BP1/NRP2 19 BP GO:0010717 regulation of epithelial to mesenchymal transition 10/819 90/18670 0.006008 0.04787 0.03671 GREM1/TCF7L2/COL1A1/BMP4/TGFBR1/FOXC1/WWTR1/LOXL2/TGFB2/MTOR 10 BP GO:0042866 pyruvate biosynthetic process 12/819 119/18670 0.006051 0.04787 0.03671 OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 12 BP GO:0006766 vitamin metabolic process 13/819 134/18670 0.006056 0.04787 0.03671 ENPP1/VDR/GSTO1/PCCB/MTHFD2/FOLR2/SNAI2/CYP3A4/CYP27A1/PLTP/MTHFD1/FLAD1/BTD 13 BP GO:0007272 ensheathment of neurons 13/819 134/18670 0.006056 0.04787 0.03671 CTSC/MYOC/NTRK2/PLP1/MYO5A/SERINC5/FIG4/TSPAN2/PMP22/LPAR1/MTOR/PIKFYVE/NAB1 13 BP GO:0008366 axon ensheathment 13/819 134/18670 0.006056 0.04787 0.03671 CTSC/MYOC/NTRK2/PLP1/MYO5A/SERINC5/FIG4/TSPAN2/PMP22/LPAR1/MTOR/PIKFYVE/NAB1 13 BP GO:0030260 entry into host cell 13/819 134/18670 0.006056 0.04787 0.03671 CD55/SLC1A5/TRIM25/TNFRSF14/MET/ITGB3/GSN/NUP153/GAS6/ITGA2/PTX3/KPNA3/ITGB1 13 BP GO:0044409 entry into host 13/819 134/18670 0.006056 0.04787 0.03671 CD55/SLC1A5/TRIM25/TNFRSF14/MET/ITGB3/GSN/NUP153/GAS6/ITGA2/PTX3/KPNA3/ITGB1 13 BP GO:0051806 entry into cell of other organism involved in symbiotic interaction 13/819 134/18670 0.006056 0.04787 0.03671 CD55/SLC1A5/TRIM25/TNFRSF14/MET/ITGB3/GSN/NUP153/GAS6/ITGA2/PTX3/KPNA3/ITGB1 13 BP GO:0051828 entry into other organism involved in symbiotic interaction 13/819 134/18670 0.006056 0.04787 0.03671 CD55/SLC1A5/TRIM25/TNFRSF14/MET/ITGB3/GSN/NUP153/GAS6/ITGA2/PTX3/KPNA3/ITGB1 13 BP GO:1904377 positive regulation of protein localization to cell periphery 8/819 63/18670 0.006072 0.04793 0.03676 EPHB2/PIK3R1/CIB1/ITGA3/STAC/SPTBN1/EZR/ITGB1 8 BP GO:0050680 negative regulation of epithelial cell proliferation 15/819 165/18670 0.006107 0.04813 0.03691 VDR/MTSS1/THBS1/SPARC/MAGED1/BMP4/GJA1/SCG2/TGFBR1/NUPR1/MCC/SNAI2/PTPRK/TGFB2/SULF1 15 BP GO:2001234 negative regulation of apoptotic signaling pathway 19/819 230/18670 0.006244 0.04914 0.03769 SIAH2/THBS1/TCF7L2/UNC5B/CXCL12/BMP4/SCG2/TGFBR1/BCL2L1/SNAI2/NRP1/HIF1A/NDUFS3/TRAP1/GCLM/ARRB2/PTTG1IP/ITGA6/BCL2 19 BP GO:0008360 regulation of cell shape 14/819 150/18670 0.006311 0.04945 0.03793 PLXND1/ITGB2/CDC42EP1/MYO10/TPM1/MYH9/DIAPH1/S100A13/EPS8/PALM/RASA1/PLXNC1/LPAR1/EZR 14 BP GO:0071774 response to fibroblast growth factor 14/819 150/18670 0.006311 0.04945 0.03793 MAPK3/POLR2L/THBS1/KDM5B/POLR2E/POSTN/COL1A1/IQGAP1/GCLM/ITGB1BP1/SULF1/ZFP36/TNC/PTPN11 14 BP GO:0072525 pyridine-containing compound biosynthetic process 14/819 150/18670 0.006311 0.04945 0.03793 NADK/IDH2/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 14 BP GO:0045185 maintenance of protein location 11/819 105/18670 0.006336 0.04948 0.03795 LTBP1/KDELR3/RANGAP1/TXN/HSPA5/FBN2/GSN/TWF2/ARL2/FLNB/EZR 11 BP GO:0042692 muscle cell differentiation 28/819 385/18670 0.00634 0.04948 0.03795 GREM1/PIN1/ATP2A2/FZD7/RAMP2/ADAM12/COMP/BMP4/MAML1/TPM1/MYH9/CSRP2/TMOD1/LOX/CAV3/ARRB2/RGS2/IL4R/MTOR/BCL2/MAP2K4/ASF1A/BIN1/LMOD1/DYRK1B/ITGB1/SORBS2/CAMK1 28 BP GO:0070588 calcium ion transmembrane transport 24/819 315/18670 0.006342 0.04948 0.03795 GSTO1/CLIC2/CEMIP/ATP2A2/HSPA2/MYO5A/PDE4B/GNB5/DIAPH1/ITPR3/CAV3/THY1/ATP1B1/STAC/GAS6/GRIN2B/PLCB1/CACNA1C/HTR2B/BIN1/PHB/ASIC1/TRPC6/GRIN2A 24 BP GO:0022407 regulation of cell-cell adhesion 29/819 403/18670 0.006391 0.04979 0.03819 CD55/PRKCA/CXCL12/BMP4/PIK3R1/CD70/IL12A/ITGB2/MYO10/TNFRSF14/SNAI2/PODXL/HAS2/CD24/THY1/KLF4/ADAM19/JAK2/ITGA6/SOCS5/IL6ST/IL4R/BAD/PTPN11/PAWR/SDC4/NCK1/HLX/HLA-DPB1 29 BP GO:0032481 positive regulation of type I interferon production 9/819 77/18670 0.006441 0.05003 0.03837 POLR2L/POLR2E/LRRFIP1/POLR3D/XRCC6/POLR3G/IRF7/PTPN11/CREBBP 9 BP GO:0048332 mesoderm morphogenesis 9/819 77/18670 0.006441 0.05003 0.03837 BMP4/FOXC1/ITGB3/ITGA3/KLF4/WNT11/KDM6A/ITGA2/ITGB1 9 BP GO:0002698 negative regulation of immune effector process 12/819 120/18670 0.006463 0.05006 0.0384 CD55/THOC1/MICB/GRN/ANGPT1/ABR/IL13RA2/TGFB2/ARRB2/SOCS5/IL4R/HLX 12 BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 12/819 120/18670 0.006463 0.05006 0.0384 THBS1/LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2/NREP/LOX/ITGA3/CAV3/CREBBP 12 BP GO:0014909 smooth muscle cell migration 10/819 91/18670 0.006492 0.05022 0.03851 POSTN/TPM1/IQGAP1/NRP1/ITGB3/HAS2/PDGFA/LPAR1/BCL2/ITGA2 10 BP GO:0000731 DNA synthesis involved in DNA repair 7/819 51/18670 0.006558 0.05044 0.03868 ISG15/RFC3/TRIM25/RPA3/USP10/POLD2/RCHY1 7 BP GO:0021545 cranial nerve development 7/819 51/18670 0.006558 0.05044 0.03868 EPHB2/ADARB1/NRP1/TFAP2A/LPAR1/TCIRG1/NRP2 7 BP GO:0030834 regulation of actin filament depolymerization 7/819 51/18670 0.006558 0.05044 0.03868 TMOD1/CAPZA2/GSN/TWF2/EPS8/SPTBN1/LMOD1 7 BP GO:0031103 axon regeneration 7/819 51/18670 0.006558 0.05044 0.03868 GRN/GAP43/NREP/KLF4/JAK2/BCL2/TNC 7 BP GO:0006898 receptor-mediated endocytosis 24/819 316/18670 0.006588 0.0506 0.03881 SFRP4/GREM1/HIP1R/SPARC/CLN3/SH3GL2/CLTB/RAMP2/ANGPT1/FOLR2/ITGB2/HSPG2/KIAA1107/CD2AP/ITGB3/PIK3CB/CAV3/ARRB2/HTR2B/AP2B1/PDLIM7/EZR/VLDLR/ITGB1 24 BP GO:0030204 chondroitin sulfate metabolic process 6/819 39/18670 0.006619 0.05062 0.03882 BGN/CHST7/CHSY1/IDS/VCAN/NCAN 6 BP GO:0045684 positive regulation of epidermis development 6/819 39/18670 0.006619 0.05062 0.03882 SFRP4/VDR/BMP4/FOXC1/TGFB2/SULT2B1 6 BP GO:0072350 tricarboxylic acid metabolic process 6/819 39/18670 0.006619 0.05062 0.03882 IDH2/ACO2/SDHA/OGDH/SDHB/MDH2 6 BP GO:0006826 iron ion transport 8/819 64/18670 0.00668 0.05098 0.0391 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 BP GO:1903169 regulation of calcium ion transmembrane transport 14/819 151/18670 0.006684 0.05098 0.0391 GSTO1/CLIC2/CEMIP/HSPA2/MYO5A/PDE4B/GNB5/DIAPH1/CAV3/THY1/ATP1B1/STAC/CACNA1C/BIN1 14 BP GO:0035966 response to topologically incorrect protein 17/819 199/18670 0.00679 0.0515 0.03949 THBS4/STC2/THBS1/CREB3L2/KDELR3/SERPINH1/COMP/ATP6V0D1/PIK3R1/IGFBP1/HSPA5/HSPA2/GOSR2/DNAJB5/MBTPS1/CTDSP2/NCK1 17 BP GO:0001958 endochondral ossification 5/819 28/18670 0.006805 0.0515 0.03949 COL1A1/BMP4/FOXC1/PEX7/NAB1 5 BP GO:0002691 regulation of cellular extravasation 5/819 28/18670 0.006805 0.0515 0.03949 CXCL12/ABR/THY1/BST1/PLCB1 5 BP GO:0018146 keratan sulfate biosynthetic process 5/819 28/18670 0.006805 0.0515 0.03949 SLC35D2/FMOD/B4GALT2/CHST2/ACAN 5 BP GO:0036075 replacement ossification 5/819 28/18670 0.006805 0.0515 0.03949 COL1A1/BMP4/FOXC1/PEX7/NAB1 5 BP GO:0033209 tumor necrosis factor-mediated signaling pathway 15/819 167/18670 0.006809 0.0515 0.03949 PSMD8/PSMB7/CD70/PSMD1/TNFRSF14/PSMB6/JAK2/GAS6/TNFRSF17/TNFRSF11B/KRT18/PSMD3/FOXO3/PSMD2/PSMB8 15 BP GO:0062012 regulation of small molecule metabolic process 32/819 459/18670 0.006834 0.05161 0.03958 ENPP1/VDR/TM7SF2/PSMD8/LPGAT1/PSMB7/ABCG1/NUPR1/PSMD1/KAT2B/NR1H2/NR1H3/SNAI2/FBP1/HIF1A/PSMB6/HAS2/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/MTOR/COX7A2/BAD/MBTPS1/PDK2/PSMD3/PSMD2/PSMB8/NFYB 32 BP GO:0072311 glomerular epithelial cell differentiation 4/819 18/18670 0.006874 0.05185 0.03976 BMP4/IQGAP1/PODXL/CD24 4 BP GO:0046718 viral entry into host cell 12/819 121/18670 0.006897 0.05195 0.03984 CD55/SLC1A5/TRIM25/TNFRSF14/ITGB3/GSN/NUP153/GAS6/ITGA2/PTX3/KPNA3/ITGB1 12 BP GO:0035710 CD4-positive, alpha-beta T cell activation 10/819 92/18670 0.007006 0.05269 0.04041 CD55/IL18R1/IL12A/STAT3/RSAD2/SOCS5/IL4R/MTOR/TCIRG1/HLX 10 BP GO:0048738 cardiac muscle tissue development 19/819 233/18670 0.007146 0.05367 0.04116 GREM1/COL11A1/PIN1/FZD7/BMP4/MAML1/GJA1/TGFBR1/FOXC1/GJC1/TPM1/CAV3/TGFB2/ARRB2/RGS2/MTOR/MAP2K4/ITGB1/SORBS2 19 BP GO:0003179 heart valve morphogenesis 7/819 52/18670 0.007298 0.05459 0.04187 EMILIN1/BMP4/ELN/SNAI2/TGFB2/MTOR/SOX4 7 BP GO:0006301 postreplication repair 7/819 52/18670 0.007298 0.05459 0.04187 ISG15/RFC3/TRIM25/RPA3/USP10/POLD2/RCHY1 7 BP GO:0032330 regulation of chondrocyte differentiation 7/819 52/18670 0.007298 0.05459 0.04187 GREM1/BMP4/TGFBR1/SOX5/SNAI2/EFEMP1/LOXL2 7 BP GO:0036294 cellular response to decreased oxygen levels 18/819 217/18670 0.007335 0.05479 0.04202 STC2/PSMD8/PSMB7/PSMD1/HIF1A/PSMB6/EPAS1/PDK1/MTOR/BAD/KCNMB1/BCL2/PSMD3/TRPC6/FOXO3/PSMD2/PSMB8/CREBBP 18 BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 12/819 122/18670 0.007353 0.05485 0.04207 THBS1/LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2/NREP/LOX/ITGA3/CAV3/CREBBP 12 BP GO:0045807 positive regulation of endocytosis 14/819 153/18670 0.007483 0.05575 0.04275 SFRP4/GREM1/HIP1R/CD151/ANGPT1/ABR/RAPGEF1/CAV3/ARRB2/GAS6/TSG101/AP2B1/ITGA2/PTX3 14 BP GO:0072583 clathrin-dependent endocytosis 6/819 40/18670 0.007504 0.05583 0.04281 HIP1R/SH3GL2/CLTB/KIAA1107/PIK3CB/AP2B1 6 BP GO:0034976 response to endoplasmic reticulum stress 22/819 285/18670 0.007532 0.0559 0.04287 THBS4/STC2/THBS1/CREB3L2/KDELR3/ATP2A2/SEL1L/ATP6V0D1/PIK3R1/IGFBP1/NUPR1/HSPA5/BCL2L1/TRIM25/GOSR2/MAP3K5/PIK3R2/UBE2J1/BCL2/MBTPS1/CTDSP2/NCK1 22 BP GO:0060537 muscle tissue development 29/819 408/18670 0.007535 0.0559 0.04287 COL3A1/GREM1/ARNTL/COL11A1/PIN1/FZD7/BMP4/MAML1/GJA1/TGFBR1/FOXC1/ELN/GJC1/NUPR1/TPM1/CSRP2/MYLK/LOX/FLNB/CAV3/TGFB2/ARRB2/RGS2/MTOR/BCL2/MAP2K4/ITGB1/HLX/SORBS2 29 BP GO:0031668 cellular response to extracellular stimulus 21/819 268/18670 0.007558 0.05597 0.04293 MAPK3/VDR/POSTN/COL1A1/RRAGD/FOLR2/PRKD1/HSPA5/PIK3C3/INHBB/SNAI2/MAP3K5/CLEC16A/GAS6/ITGA6/MTOR/P2RY2/BCL2/TNC/PDK2/MAP1LC3B 21 BP GO:1903708 positive regulation of hemopoiesis 16/819 185/18670 0.007565 0.05597 0.04293 PRKCA/ISG15/FOXC1/IL12A/HAX1/HIF1A/PRMT1/CCR1/STAT3/GAS6/SOCS5/IL4R/BAD/ROR2/FOXO3/HLX 16 BP GO:0031110 regulation of microtubule polymerization or depolymerization 9/819 79/18670 0.007607 0.05605 0.04299 CIB1/FKBP4/MET/ARL2/MAPRE3/CAV3/CLIP1/CAMSAP2/MAP1A 9 BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 9/819 79/18670 0.007607 0.05605 0.04299 PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/TAP1/PSMD2/PSMB8/VAMP3 9 BP GO:0071260 cellular response to mechanical stimulus 9/819 79/18670 0.007607 0.05605 0.04299 MAPK3/COL1A1/GJA1/HABP4/WNT11/BAD/MAP2K4/ITGA2/PTPN11 9 BP GO:0002683 negative regulation of immune system process 32/819 463/18670 0.007722 0.05683 0.04358 COL3A1/GREM1/CD55/THOC1/THBS1/CXCL12/EMILIN1/MICB/GRN/BMP4/ANGPT1/PIK3R1/ADAR/NR1H2/NR1H3/CIB1/ABR/TNFRSF14/PRMT1/IL13RA2/THY1/TGFB2/ARRB2/ZFP36/SOCS5/IL4R/PLCB1/PAWR/SDC4/EZR/PKN1/HLX 32 BP GO:0032526 response to retinoic acid 11/819 108/18670 0.0078 0.05724 0.0439 IGFBP7/FZD7/COL1A1/MICB/PTK7/GJA1/ADNP2/TWF2/KLF4/WNT11/TNC 11 BP GO:2000278 regulation of DNA biosynthetic process 11/819 108/18670 0.0078 0.05724 0.0439 MAPK3/GREM1/MAP3K4/GJA1/RFC3/NEK7/DNAJC2/ARRB2/KLF4/TERF2/CCT7 11 BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 5/819 29/18670 0.007932 0.0579 0.0444 GSTO1/CLIC2/ATP2A2/ATP1B1/CACNA1C 5 BP GO:0021602 cranial nerve morphogenesis 5/819 29/18670 0.007932 0.0579 0.0444 EPHB2/ADARB1/NRP1/TFAP2A/NRP2 5 BP GO:0070102 interleukin-6-mediated signaling pathway 5/819 29/18670 0.007932 0.0579 0.0444 STAT3/JAK2/IL6ST/SOCS3/PTPN11 5 BP GO:2000727 positive regulation of cardiac muscle cell differentiation 5/819 29/18670 0.007932 0.0579 0.0444 GREM1/PIN1/BMP4/ARRB2/MTOR 5 BP GO:0006930 substrate-dependent cell migration, cell extension 3/819 10/18670 0.008006 0.0579 0.0444 NRP1/CD2AP/NCK1 3 BP GO:0007084 mitotic nuclear envelope reassembly 3/819 10/18670 0.008006 0.0579 0.0444 BANF1/ANKLE2/PPP2R1A 3 BP GO:0032836 glomerular basement membrane development 3/819 10/18670 0.008006 0.0579 0.0444 NID1/MPV17/SULF1 3 BP GO:0045625 regulation of T-helper 1 cell differentiation 3/819 10/18670 0.008006 0.0579 0.0444 SOCS5/IL4R/HLX 3 BP GO:0051006 positive regulation of lipoprotein lipase activity 3/819 10/18670 0.008006 0.0579 0.0444 ABHD5/NR1H2/NR1H3 3 BP GO:0060346 bone trabecula formation 3/819 10/18670 0.008006 0.0579 0.0444 GREM1/COL1A1/FBN2 3 BP GO:0072015 glomerular visceral epithelial cell development 3/819 10/18670 0.008006 0.0579 0.0444 BMP4/IQGAP1/PODXL 3 BP GO:0000186 activation of MAPKK activity 7/819 53/18670 0.008098 0.05841 0.04479 MAPK3/MAP3K4/BMP4/TGFBR1/MAP3K5/RAPGEF1/JAK2 7 BP GO:0038066 p38MAPK cascade 7/819 53/18670 0.008098 0.05841 0.04479 MAP3K4/SASH1/MAP3K5/PRMT1/CAV3/ZFP36/EZR 7 BP GO:0007266 Rho protein signal transduction 17/819 203/18670 0.008224 0.05923 0.04543 COL3A1/COL1A2/MYOC/ARHGEF17/MCF2L/CDC42EP1/ABR/NRP1/MET/ITGA3/EPS8/ARHGEF15/LPAR1/CTNNAL1/PHACTR4/RHOBTB2/ITGB1 17 BP GO:0048194 Golgi vesicle budding 9/819 80/18670 0.008247 0.05932 0.0455 CTSC/GOSR2/NAPA/COL7A1/ARFGAP2/SEC13/SEC23B/LMAN1/TMED2 9 BP GO:0014897 striated muscle hypertrophy 11/819 109/18670 0.008343 0.05978 0.04585 MYOC/PIN1/PRKCA/ATP2A2/CAV3/RGS2/IL6ST/MTOR/MAP2K4/HTR2B/SORBS2 11 BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 14/819 155/18670 0.008356 0.05978 0.04585 SIAH2/THBS1/TCF7L2/UNC5B/BMP4/SCG2/TGFBR1/BCL2L1/SNAI2/NRP1/GCLM/ITGA6/BCL2/PPP2R1A 14 BP GO:0006044 N-acetylglucosamine metabolic process 4/819 19/18670 0.00841 0.05978 0.04585 RENBP/CHST7/CHST2/GNPDA1 4 BP GO:0019184 nonribosomal peptide biosynthetic process 4/819 19/18670 0.00841 0.05978 0.04585 GGT5/HAGH/GGCT/GCLM 4 BP GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway 4/819 19/18670 0.00841 0.05978 0.04585 HIF1A/ITGB3/GRB10/PRKCB 4 BP GO:0032026 response to magnesium ion 4/819 19/18670 0.00841 0.05978 0.04585 THBS1/FBP1/CNGA3/TNFRSF11B 4 BP GO:0046112 nucleobase biosynthetic process 4/819 19/18670 0.00841 0.05978 0.04585 GART/MTHFD1/MTOR/CTPS1 4 BP GO:0048486 parasympathetic nervous system development 4/819 19/18670 0.00841 0.05978 0.04585 ADARB1/NRP1/TFAP2A/NRP2 4 BP GO:1990182 exosomal secretion 4/819 19/18670 0.00841 0.05978 0.04585 STAM/CHMP2A/TSG101/SDC4 4 BP GO:0042572 retinol metabolic process 6/819 41/18670 0.008472 0.06007 0.04607 CYP1B1/ADH1C/CYP3A4/ADH1A/ADH1B/ALDH1A3 6 BP GO:1905209 positive regulation of cardiocyte differentiation 6/819 41/18670 0.008472 0.06007 0.04607 GREM1/PIN1/BMP4/TGFB2/ARRB2/MTOR 6 BP GO:0009314 response to radiation 31/819 448/18670 0.008509 0.06025 0.04621 COL3A1/ADIRF/CTNS/MAP3K4/CRYAB/CXCL12/TXN/PIK3R1/B4GALT2/HSPA5/IL12A/MBD4/BCL2L1/POLE3/SNAI2/XRCC6/TYR/HIF1A/CDS1/PTPRK/NMT1/HMGN1/MTOR/BCL2/CAT/PER2/CASP9/XPC/GRIN2A/CREBBP/ITGB1 31 BP GO:0072073 kidney epithelium development 13/819 140/18670 0.008664 0.06127 0.04699 CRLF1/MTSS1/MAGED1/BMP4/FOXC1/WWTR1/IQGAP1/PODXL/CD24/WNT11/BCL2/CAT/SDC4 13 BP GO:0051196 regulation of coenzyme metabolic process 10/819 95/18670 0.008737 0.06171 0.04732 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/PDK2 10 BP GO:0009142 nucleoside triphosphate biosynthetic process 16/819 188/18670 0.008772 0.06177 0.04737 NME3/AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/COX5B/STAT3/SEC13/PGM1/TPI1/CTPS1 16 BP GO:0030858 positive regulation of epithelial cell differentiation 8/819 67/18670 0.00878 0.06177 0.04737 SFRP4/VDR/RFX3/BMP4/FOXC1/CD24/BAD/SULT2B1 8 BP GO:2000573 positive regulation of DNA biosynthetic process 8/819 67/18670 0.00878 0.06177 0.04737 MAPK3/GREM1/MAP3K4/RFC3/NEK7/ARRB2/KLF4/CCT7 8 BP GO:0030258 lipid modification 19/819 238/18670 0.00888 0.06231 0.04779 PI4K2A/SYNJ2/ECI1/ABCG1/PIK3R1/PIK3C3/AUH/CYP3A4/HADH/PIK3R2/PIK3CB/PEX7/SOCS5/SOCS3/MTOR/ETFB/INPP5E/PIP5K1A/PIKFYVE 19 BP GO:0046578 regulation of Ras protein signal transduction 19/819 238/18670 0.00888 0.06231 0.04779 COL3A1/MYOC/EPHB2/ARHGEF17/MCF2L/ABR/FBP1/NRP1/MET/ITGA3/EPS8/RAPGEF1/ARHGEF15/TGFB2/RASA1/JAK2/LPAR1/CYTH1/ITGB1 19 BP GO:0031145 anaphase-promoting complex-dependent catabolic process 9/819 81/18670 0.008928 0.06248 0.04792 PSMD8/PSMB7/PSMD1/PSMB6/UBE2E1/ANAPC15/PSMD3/PSMD2/PSMB8 9 BP GO:0048708 astrocyte differentiation 9/819 81/18670 0.008928 0.06248 0.04792 MAPK3/GRN/PLP1/TSPAN2/STAT3/IL6ST/ROR2/BIN1/PTPN11 9 BP GO:0070206 protein trimerization 7/819 54/18670 0.008961 0.06264 0.04804 COL1A2/EMILIN1/COL1A1/SLC1A5/SIGMAR1/ASIC1/HSF4 7 BP GO:0051491 positive regulation of filopodium assembly 5/819 30/18670 0.009181 0.06393 0.04903 TGFBR1/DPYSL3/NRP1/FSCN1/PALM 5 BP GO:0070168 negative regulation of biomineral tissue development 5/819 30/18670 0.009181 0.06393 0.04903 ENPP1/GREM1/HIF1A/CCR1/GAS6 5 BP GO:0071480 cellular response to gamma radiation 5/819 30/18670 0.009181 0.06393 0.04903 CRYAB/HSPA5/BCL2L1/POLE3/XRCC6 5 BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 10/819 96/18670 0.009382 0.06516 0.04997 PSMD8/PSMB7/PSMD1/PSMB6/SEC13/PSMD3/TAP1/PSMD2/PSMB8/VAMP3 10 BP GO:0090277 positive regulation of peptide hormone secretion 10/819 96/18670 0.009382 0.06516 0.04997 NADK/OXCT1/TCF7L2/ADCY8/GJA1/MYRIP/HIF1A/JAK2/BAD/SOX4 10 BP GO:0018107 peptidyl-threonine phosphorylation 12/819 126/18670 0.009422 0.06527 0.05006 CEMIP/PRKCA/TGFBR1/PRKD1/PRKCB/MTOR/BCL2/PPP2R5D/CHI3L1/TRPC6/PKN1/DYRK1B 12 BP GO:0032479 regulation of type I interferon production 12/819 126/18670 0.009422 0.06527 0.05006 POLR2L/POLR2E/PIN1/ISG15/TRIM25/LRRFIP1/POLR3D/XRCC6/POLR3G/IRF7/PTPN11/CREBBP 12 BP GO:0014896 muscle hypertrophy 11/819 111/18670 0.009515 0.06583 0.05049 MYOC/PIN1/PRKCA/ATP2A2/CAV3/RGS2/IL6ST/MTOR/MAP2K4/HTR2B/SORBS2 11 BP GO:0050918 positive chemotaxis 8/819 68/18670 0.009579 0.06619 0.05076 CXCL12/BMP4/ANGPT1/SCG2/VEGFC/NRP1/MET/ITGA2 8 BP GO:0055117 regulation of cardiac muscle contraction 9/819 82/18670 0.00965 0.06659 0.05107 GSTO1/CLIC2/ATP2A2/PDE4B/CAV3/ATP1B1/RGS2/CACNA1C/BIN1 9 BP GO:0007034 vacuolar transport 13/819 142/18670 0.009706 0.0669 0.05131 DENND3/VPS41/TRAK2/GRN/ATP6V0D1/LYST/VPS11/GOSR2/CLEC16A/SNX27/CHMP2A/TSG101/BIN1 13 BP GO:0001541 ovarian follicle development 7/819 55/18670 0.00989 0.06782 0.05201 FOXC1/BCL2L1/INHBB/ARRB2/BCL2/PTX3/FOXO3 7 BP GO:0006383 transcription by RNA polymerase III 7/819 55/18670 0.00989 0.06782 0.05201 POLR2L/POLR2E/POLR3D/POLR3G/SNAPC4/MTOR/SNAPC5 7 BP GO:0043551 regulation of phosphatidylinositol 3-kinase activity 7/819 55/18670 0.00989 0.06782 0.05201 PIK3R1/PRKD1/PIK3IP1/PIK3R2/KLF4/SOCS5/SOCS3 7 BP GO:0044273 sulfur compound catabolic process 7/819 55/18670 0.00989 0.06782 0.05201 BGN/GGT5/FMOD/IDS/ACAN/VCAN/NCAN 7 BP GO:0016054 organic acid catabolic process 21/819 275/18670 0.00998 0.06827 0.05236 RENBP/PLA2G15/ECI1/CEMIP/PCCB/SORD/PCBD1/HMGCL/DDAH2/OGDH/QDPR/AUH/HADH/FAH/PEX7/GNPDA1/MTOR/ETFB/ALDH7A1/CRYM/BCAT2 21 BP GO:0046395 carboxylic acid catabolic process 21/819 275/18670 0.00998 0.06827 0.05236 RENBP/PLA2G15/ECI1/CEMIP/PCCB/SORD/PCBD1/HMGCL/DDAH2/OGDH/QDPR/AUH/HADH/FAH/PEX7/GNPDA1/MTOR/ETFB/ALDH7A1/CRYM/BCAT2 21 BP GO:0042593 glucose homeostasis 19/819 241/18670 0.01007 0.06867 0.05267 NADK/PRCP/OXCT1/TCF7L2/ADCY8/OAS1/PIK3R1/HIF1A/PIK3R2/GCLM/CAV3/STAT3/GAS6/UNC13B/BAD/PTPN11/PDK2/FOXO3/SOX4 19 BP GO:0042594 response to starvation 16/819 191/18670 0.01013 0.06867 0.05267 MAPK3/OXCT1/HMGCL/RRAGD/PRKD1/HSPA5/PIK3C3/INHBB/MAP3K5/CLEC16A/GAS6/ZFP36/MTOR/BCL2/MAP1LC3B/FOXO3 16 BP GO:0001502 cartilage condensation 4/819 20/18670 0.01015 0.06867 0.05267 BMP1/COL11A1/ROR2/ACAN 4 BP GO:0003323 type B pancreatic cell development 4/819 20/18670 0.01015 0.06867 0.05267 ARNTL/RFX3/BMP4/BAD 4 BP GO:0046931 pore complex assembly 4/819 20/18670 0.01015 0.06867 0.05267 NUP205/NUP93/NUP153/BAD 4 BP GO:0051016 barbed-end actin filament capping 4/819 20/18670 0.01015 0.06867 0.05267 CAPZA2/GSN/TWF2/EPS8 4 BP GO:0051580 regulation of neurotransmitter uptake 4/819 20/18670 0.01015 0.06867 0.05267 ITGB3/GPM6B/RGS2/PER2 4 BP GO:0070828 heterochromatin organization 4/819 20/18670 0.01015 0.06867 0.05267 POLE3/LOXL2/HMGA1/CDKN2A 4 BP GO:0097734 extracellular exosome biogenesis 4/819 20/18670 0.01015 0.06867 0.05267 STAM/CHMP2A/TSG101/SDC4 4 BP GO:0006606 protein import into nucleus 13/819 143/18670 0.01026 0.06884 0.05279 ARNTL/BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/NUP93/NUP153/PIK3R2/STAT3/PTTG1IP/MBTPS1/KPNA3 13 BP GO:0035296 regulation of tube diameter 13/819 143/18670 0.01026 0.06884 0.05279 ITGA1/COMP/GJA1/FOXC1/GCLM/ITGB1BP1/RGS2/P2RY2/KCNMB1/HTR2B/EDNRA/ACTA2/PER2 13 BP GO:0044344 cellular response to fibroblast growth factor stimulus 13/819 143/18670 0.01026 0.06884 0.05279 MAPK3/POLR2L/THBS1/KDM5B/POLR2E/POSTN/COL1A1/IQGAP1/GCLM/ITGB1BP1/SULF1/ZFP36/PTPN11 13 BP GO:0050880 regulation of blood vessel size 13/819 143/18670 0.01026 0.06884 0.05279 ITGA1/COMP/GJA1/FOXC1/GCLM/ITGB1BP1/RGS2/P2RY2/KCNMB1/HTR2B/EDNRA/ACTA2/PER2 13 BP GO:0097746 regulation of blood vessel diameter 13/819 143/18670 0.01026 0.06884 0.05279 ITGA1/COMP/GJA1/FOXC1/GCLM/ITGB1BP1/RGS2/P2RY2/KCNMB1/HTR2B/EDNRA/ACTA2/PER2 13 BP GO:0120032 regulation of plasma membrane bounded cell projection assembly 15/819 175/18670 0.01029 0.06884 0.05279 PLEKHM1/GAP43/TGFBR1/CDC42EP1/MYO10/DPYSL3/NRP1/PODXL/TWF2/FSCN1/EPS8/PALM/MTOR/SH3YL1/CDKL1 15 BP GO:0010038 response to metal ion 26/819 364/18670 0.01036 0.06884 0.05279 MAPK3/THBS1/SPARC/SORD/ADCY8/SOD3/ADCY7/HSPA5/QDPR/IQGAP1/FBP1/TFAP2A/S100A13/HIF1A/ITPR3/GSN/UROS/LOXL2/CNGA3/TNFRSF11B/BAD/KCNMB1/BCL2/TCIRG1/CAT/CASP9 26 BP GO:0006970 response to osmotic stress 9/819 83/18670 0.01042 0.06884 0.05279 SORD/FMO1/MYLK/XRCC6/NOLC1/SERPINB6/BAD/ITGA2/PKN1 9 BP GO:0060218 hematopoietic stem cell differentiation 9/819 83/18670 0.01042 0.06884 0.05279 PSMD8/LMO2/PSMB7/FOXC1/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 9 BP GO:0071300 cellular response to retinoic acid 8/819 69/18670 0.01043 0.06884 0.05279 FZD7/COL1A1/PTK7/ADNP2/TWF2/KLF4/WNT11/TNC 8 BP GO:0033500 carbohydrate homeostasis 19/819 242/18670 0.0105 0.06884 0.05279 NADK/PRCP/OXCT1/TCF7L2/ADCY8/OAS1/PIK3R1/HIF1A/PIK3R2/GCLM/CAV3/STAT3/GAS6/UNC13B/BAD/PTPN11/PDK2/FOXO3/SOX4 19 BP GO:0045648 positive regulation of erythrocyte differentiation 5/819 31/18670 0.01056 0.06884 0.05279 ISG15/HIF1A/PRMT1/STAT3/FOXO3 5 BP GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 5/819 31/18670 0.01056 0.06884 0.05279 BGN/CHST7/CHSY1/VCAN/NCAN 5 BP GO:1903319 positive regulation of protein maturation 5/819 31/18670 0.01056 0.06884 0.05279 MYH9/GSN/SPON1/PHB/SOX4 5 BP GO:0002576 platelet degranulation 12/819 128/18670 0.01061 0.06884 0.05279 ACTN1/RARRES2/THBS1/SPARC/VEGFC/HABP4/RAB27B/ABCC4/ITGB3/PDGFA/TGFB2/GAS6 12 BP GO:0002687 positive regulation of leukocyte migration 12/819 128/18670 0.01061 0.06884 0.05279 MAPK3/RARRES2/THBS4/THBS1/CXCL12/VEGFC/IL12A/TNFRSF14/CCR1/THY1/GAS6/ITGA2 12 BP GO:0032606 type I interferon production 12/819 128/18670 0.01061 0.06884 0.05279 POLR2L/POLR2E/PIN1/ISG15/TRIM25/LRRFIP1/POLR3D/XRCC6/POLR3G/IRF7/PTPN11/CREBBP 12 BP GO:0034763 negative regulation of transmembrane transport 12/819 128/18670 0.01061 0.06884 0.05279 ENPP1/GSTO1/CLIC2/THBS1/EPHB2/GNB5/GRB10/CAV3/RGS2/PRKCB/MTOR/BIN1 12 BP GO:0001767 establishment of lymphocyte polarity 3/819 11/18670 0.01065 0.06884 0.05279 MYH9/GSN/SNX27 3 BP GO:0006054 N-acetylneuraminate metabolic process 3/819 11/18670 0.01065 0.06884 0.05279 RENBP/ST6GAL1/GNPDA1 3 BP GO:0006558 L-phenylalanine metabolic process 3/819 11/18670 0.01065 0.06884 0.05279 PCBD1/QDPR/FAH 3 BP GO:0006559 L-phenylalanine catabolic process 3/819 11/18670 0.01065 0.06884 0.05279 PCBD1/QDPR/FAH 3 BP GO:0021561 facial nerve development 3/819 11/18670 0.01065 0.06884 0.05279 ADARB1/NRP1/NRP2 3 BP GO:0021610 facial nerve morphogenesis 3/819 11/18670 0.01065 0.06884 0.05279 ADARB1/NRP1/NRP2 3 BP GO:0033629 negative regulation of cell adhesion mediated by integrin 3/819 11/18670 0.01065 0.06884 0.05279 CYP1B1/SNAI2/PTPN11 3 BP GO:0035457 cellular response to interferon-alpha 3/819 11/18670 0.01065 0.06884 0.05279 IFIT2/GAS6/IFIT3 3 BP GO:0045628 regulation of T-helper 2 cell differentiation 3/819 11/18670 0.01065 0.06884 0.05279 SOCS5/IL4R/HLX 3 BP GO:0060992 response to fungicide 3/819 11/18670 0.01065 0.06884 0.05279 KDM5B/BCL2L1/KLF4 3 BP GO:0061365 positive regulation of triglyceride lipase activity 3/819 11/18670 0.01065 0.06884 0.05279 ABHD5/NR1H2/NR1H3 3 BP GO:0072310 glomerular epithelial cell development 3/819 11/18670 0.01065 0.06884 0.05279 BMP4/IQGAP1/PODXL 3 BP GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 3/819 11/18670 0.01065 0.06884 0.05279 PCBD1/QDPR/FAH 3 BP GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 3/819 11/18670 0.01065 0.06884 0.05279 PCBD1/QDPR/FAH 3 BP GO:1902563 regulation of neutrophil activation 3/819 11/18670 0.01065 0.06884 0.05279 GRN/ITGB2/ABR 3 BP GO:1905383 protein localization to presynapse 3/819 11/18670 0.01065 0.06884 0.05279 RAB27B/TERF2/MAP1A 3 BP GO:0042088 T-helper 1 type immune response 6/819 43/18670 0.01067 0.06884 0.05279 IL18R1/IL12A/SOCS5/IL4R/MTOR/HLX 6 BP GO:0043616 keratinocyte proliferation 6/819 43/18670 0.01067 0.06884 0.05279 VDR/PRKD1/SNAI2/HAS2/PTPRK/ZFP36 6 BP GO:0045429 positive regulation of nitric oxide biosynthetic process 6/819 43/18670 0.01067 0.06884 0.05279 DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 6 BP GO:0071364 cellular response to epidermal growth factor stimulus 6/819 43/18670 0.01067 0.06884 0.05279 COL1A1/FOXC1/IQGAP1/SNAI2/ZFP36/PTPN11 6 BP GO:1901985 positive regulation of protein acetylation 6/819 43/18670 0.01067 0.06884 0.05279 MAPK3/ARNTL/SNAI2/WBP2/SOX4/CAMK1 6 BP GO:0042472 inner ear morphogenesis 10/819 98/18670 0.01078 0.06937 0.0532 LRIG1/COL11A1/EPHB2/PTK7/FZD2/ABR/TFAP2A/FZD6/ROR2/ALDH1A3 10 BP GO:0060191 regulation of lipase activity 10/819 98/18670 0.01078 0.06937 0.0532 PCSK5/ABHD5/NTRK2/ARF4/NR1H2/NR1H3/RGS2/LPAR1/HTR2B/EDNRA 10 BP GO:0043244 regulation of protein complex disassembly 11/819 113/18670 0.01081 0.06949 0.05329 CIB1/TMOD1/CAPZA2/CLEC16A/GSN/TWF2/EPS8/CAMSAP2/SPTBN1/MAP1A/LMOD1 11 BP GO:0035150 regulation of tube size 13/819 144/18670 0.01084 0.06949 0.05329 ITGA1/COMP/GJA1/FOXC1/GCLM/ITGB1BP1/RGS2/P2RY2/KCNMB1/HTR2B/EDNRA/ACTA2/PER2 13 BP GO:0000768 syncytium formation by plasma membrane fusion 7/819 56/18670 0.01089 0.06949 0.05329 ADAM12/MYH9/CAV3/IL4R/SH3PXD2A/DYRK1B/CAMK1 7 BP GO:0050879 multicellular organismal movement 7/819 56/18670 0.01089 0.06949 0.05329 GSTO1/ATP2A2/COMP/CAV3/STAC/MTOR/MAP1A 7 BP GO:0050881 musculoskeletal movement 7/819 56/18670 0.01089 0.06949 0.05329 GSTO1/ATP2A2/COMP/CAV3/STAC/MTOR/MAP1A 7 BP GO:0072528 pyrimidine-containing compound biosynthetic process 7/819 56/18670 0.01089 0.06949 0.05329 NME3/TK2/CDS1/CDS2/MTOR/AGPAT1/CTPS1 7 BP GO:0140253 cell-cell fusion 7/819 56/18670 0.01089 0.06949 0.05329 ADAM12/MYH9/CAV3/IL4R/SH3PXD2A/DYRK1B/CAMK1 7 BP GO:0051271 negative regulation of cellular component movement 27/819 384/18670 0.01107 0.07058 0.05413 COL3A1/GREM1/ACTN1/IDH2/THBS1/CYP1B1/PIN1/CXCL12/EMILIN1/ADARB1/MCC/ADAM15/DPYSL3/ABR/TPM1/NRP1/PTPRK/THY1/STAT3/KLF4/ITGB1BP1/SULF1/WNT11/BCL2/PLCB1/BIN1/FOXO3 27 BP GO:0007219 Notch signaling pathway 16/819 193/18670 0.01112 0.07081 0.0543 POSTN/SEL1L/MAML1/PLXND1/FOXC1/KAT2B/DLK1/SNAI2/STAT3/TGFB2/NOTCH3/ITGB1BP1/IL6ST/ZNF423/CREBBP/SORBS2 16 BP GO:0014910 regulation of smooth muscle cell migration 9/819 84/18670 0.01123 0.0714 0.05476 POSTN/TPM1/IQGAP1/NRP1/HAS2/PDGFA/LPAR1/BCL2/ITGA2 9 BP GO:0097529 myeloid leukocyte migration 17/819 210/18670 0.01131 0.07174 0.05502 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/EMILIN1/ITGA1/SCG2/VEGFC/ITGB2/PDE4B/CCR1/BST1/TGFB2/ROR2/PLCB1 17 BP GO:0006901 vesicle coating 8/819 70/18670 0.01134 0.07174 0.05502 CTSC/GOSR2/NAPA/COL7A1/ARFGAP2/SEC13/LMAN1/TMED2 8 BP GO:0060395 SMAD protein signal transduction 8/819 70/18670 0.01134 0.07174 0.05502 BMP4/TGFBR1/WWTR1/INHBB/NUP93/TGFB2/ROR2/SPTBN1 8 BP GO:0009201 ribonucleoside triphosphate biosynthetic process 15/819 177/18670 0.01134 0.07174 0.05502 NME3/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/COX5B/STAT3/SEC13/PGM1/TPI1/CTPS1 15 BP GO:0060491 regulation of cell projection assembly 15/819 177/18670 0.01134 0.07174 0.05502 PLEKHM1/GAP43/TGFBR1/CDC42EP1/MYO10/DPYSL3/NRP1/PODXL/TWF2/FSCN1/EPS8/PALM/MTOR/SH3YL1/CDKL1 15 BP GO:0048545 response to steroid hormone 27/819 385/18670 0.01143 0.07211 0.0553 VDR/ARNTL/IGFBP7/ABCA3/THBS1/SPARC/RAMP2/COL1A1/BMP4/CLDN4/NR1H2/NR1H3/LOX/FKBP4/WBP2/ANXA3/TGFB2/ARRB2/CNGA3/JAK2/ZFP36/BAD/BCL2/STRN3/PHB/CASP9/FOXO3 27 BP GO:0050890 cognition 22/819 296/18670 0.01143 0.07211 0.0553 CTNS/ATP8A1/CLN3/ADCY8/EPHB2/NTRK2/CHL1/B4GALT2/ARF4/GM2A/NPTX2/HIF1A/ITPR3/ITGA3/GRIN2B/MTOR/PLCB1/MAP1A/ASIC1/GRIN2A/VLDLR/ITGB1 22 BP GO:0002688 regulation of leukocyte chemotaxis 11/819 114/18670 0.01151 0.0725 0.05561 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/VEGFC/IL12A/CCR1/BST1/GAS6 11 BP GO:0030838 positive regulation of actin filament polymerization 10/819 99/18670 0.01153 0.07251 0.05561 HIP1R/CDC42EP1/ARPC1B/GSN/MTOR/BIN1/GMFG/RHOBTB2/LMOD1/NCK1 10 BP GO:0072527 pyrimidine-containing compound metabolic process 10/819 99/18670 0.01153 0.07251 0.05561 NME3/APOBEC3B/MBD4/TK2/CDS1/CDS2/APOBEC3C/MTOR/AGPAT1/CTPS1 10 BP GO:0051168 nuclear export 16/819 194/18670 0.01164 0.07311 0.05607 THOC1/TCF7L2/RANGAP1/TXN/DDX39A/NUP205/NUP93/NUP153/RRS1/GAS6/SEC13/IFI27/PTPN11/SRSF7/AGFG1/CAMK1 16 BP GO:0048193 Golgi vesicle transport 26/819 368/18670 0.01181 0.07407 0.0568 CD55/CTSC/SCAMP3/CREB3L2/KDELR3/RAB33A/PRKD1/ARF4/GOSR2/CAPZA2/MYO5A/NAPA/DYNC1I1/COL7A1/GAS6/ARFGAP2/SEC13/RAB8A/SEC23B/KRT18/SPTBN1/KIF2C/COG4/LMAN1/VAMP3/TMED2 26 BP GO:0050654 chondroitin sulfate proteoglycan metabolic process 6/819 44/18670 0.01191 0.07453 0.05716 BGN/CHST7/CHSY1/IDS/VCAN/NCAN 6 BP GO:1904407 positive regulation of nitric oxide metabolic process 6/819 44/18670 0.01191 0.07453 0.05716 DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 6 BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 7/819 57/18670 0.01195 0.07453 0.05716 DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3/FOXO3 7 BP GO:0000723 telomere maintenance 14/819 162/18670 0.01206 0.07453 0.05716 MAPK3/MAP3K4/PRIM2/RFC3/POLE3/XRCC6/SMC5/RPA3/NEK7/TERF2/PRIM1/NHP2/CCT7/POLD2 14 BP GO:0042573 retinoic acid metabolic process 5/819 32/18670 0.01207 0.07453 0.05716 ADH1C/CYP3A4/ADH1A/ADH1B/ALDH1A3 5 BP GO:0060317 cardiac epithelial to mesenchymal transition 5/819 32/18670 0.01207 0.07453 0.05716 TGFBR1/ADAM15/SNAI2/HAS2/TGFB2 5 BP GO:0070207 protein homotrimerization 5/819 32/18670 0.01207 0.07453 0.05716 EMILIN1/SLC1A5/SIGMAR1/ASIC1/HSF4 5 BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 9/819 85/18670 0.01208 0.07453 0.05716 PSMD8/LMO2/PSMB7/FOXC1/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 9 BP GO:0006067 ethanol metabolic process 4/819 21/18670 0.01212 0.07453 0.05716 ADH1C/ADH1A/ADH1B/ALDH2 4 BP GO:0016553 base conversion or substitution editing 4/819 21/18670 0.01212 0.07453 0.05716 APOBEC3B/ADARB1/ADAR/APOBEC3C 4 BP GO:0030502 negative regulation of bone mineralization 4/819 21/18670 0.01212 0.07453 0.05716 ENPP1/GREM1/HIF1A/CCR1 4 BP GO:0030728 ovulation 4/819 21/18670 0.01212 0.07453 0.05716 INHBB/RGS2/IL4R/FOXO3 4 BP GO:0035743 CD4-positive, alpha-beta T cell cytokine production 4/819 21/18670 0.01212 0.07453 0.05716 CD55/IL18R1/IL12A/RSAD2 4 BP GO:0071498 cellular response to fluid shear stress 4/819 21/18670 0.01212 0.07453 0.05716 MTSS1/HAS2/KLF4/SOCS5 4 BP GO:0090208 positive regulation of triglyceride metabolic process 4/819 21/18670 0.01212 0.07453 0.05716 ABHD5/NR1H2/NR1H3/PNPLA2 4 BP GO:0098743 cell aggregation 4/819 21/18670 0.01212 0.07453 0.05716 BMP1/COL11A1/ROR2/ACAN 4 BP GO:2000738 positive regulation of stem cell differentiation 4/819 21/18670 0.01212 0.07453 0.05716 BMP4/FOXC1/SOX5/TGFB2 4 BP GO:0010927 cellular component assembly involved in morphogenesis 11/819 115/18670 0.01224 0.07519 0.05766 TPM1/CSRP2/TMOD1/FIG4/CAV3/PMP22/AGFG1/PIKFYVE/LMOD1/TMF1/ITGB1 11 BP GO:0042440 pigment metabolic process 8/819 71/18670 0.0123 0.07542 0.05784 CTNS/BLVRB/MYO5A/TYR/UROS/GART/MTHFD1/BCL2 8 BP GO:0055024 regulation of cardiac muscle tissue development 10/819 100/18670 0.01233 0.07542 0.05784 GREM1/PIN1/FZD7/BMP4/GJA1/TGFBR1/CAV3/ARRB2/RGS2/MTOR 10 BP GO:0070498 interleukin-1-mediated signaling pathway 10/819 100/18670 0.01233 0.07542 0.05784 MAPK3/PSMD8/PSMB7/IL1RAP/PSMD1/PSMB6/PLCB1/PSMD3/PSMD2/PSMB8 10 BP GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 10/819 100/18670 0.01233 0.07542 0.05784 PLEKHM1/TGFBR1/CDC42EP1/DPYSL3/NRP1/TWF2/FSCN1/EPS8/PALM/MTOR 10 BP GO:0048872 homeostasis of number of cells 19/819 246/18670 0.01235 0.07544 0.05785 ISG15/BMP4/ADAR/RASSF2/PDE4B/HIF1A/LIPA/EPAS1/PRMT1/PIK3CB/STAT3/JAK2/ZFP36/TNFRSF17/BCL2/TCIRG1/PTPN11/FOXO3/PKN1 19 BP GO:0050851 antigen receptor-mediated signaling pathway 23/819 316/18670 0.01244 0.07594 0.05824 PSMD8/PSMB7/PIK3R1/PSMD1/PDE4B/PSMB6/KCNN4/PIK3R2/HLA-DRB4/PIK3CB/THY1/PRKCB/IGLL1/HLA-DQB1/RAB29/BCL2/PSMD3/PAWR/PSMD2/EZR/PSMB8/NCK1/HLA-DPB1 23 BP GO:0051099 positive regulation of binding 15/819 179/18670 0.01249 0.07612 0.05838 CLIC2/HIP1R/TCF7L2/PIN1/TXN/BMP4/PLXND1/FOXC1/NRP1/MET/MAPRE3/KLF4/JAK2/SPON1/ITGA2 15 BP GO:0021987 cerebral cortex development 11/819 116/18670 0.013 0.07917 0.06072 COL3A1/LAMB1/NTRK2/TACC2/NRP1/HIF1A/GNG12/GART/BAD/PLCB1/NRP2 11 BP GO:0043534 blood vessel endothelial cell migration 15/819 180/18670 0.01309 0.07948 0.06096 GREM1/PRCP/THBS1/PRKCA/ANGPT1/VEGFC/PRKD1/CIB1/MYH9/EPHB4/NRP1/HIF1A/KLF4/ITGB1BP1/ITGB1 15 BP GO:0071346 cellular response to interferon-gamma 15/819 180/18670 0.01309 0.07948 0.06096 OAS1/OAS2/NR1H2/TRIM25/NR1H3/GSN/HLA-DRB4/FLNB/JAK2/OASL/SOCS3/HLA-DQB1/IRF7/VAMP3/HLA-DPB1 15 BP GO:0006949 syncytium formation 7/819 58/18670 0.0131 0.07948 0.06096 ADAM12/MYH9/CAV3/IL4R/SH3PXD2A/DYRK1B/CAMK1 7 BP GO:1903426 regulation of reactive oxygen species biosynthetic process 10/819 101/18670 0.01316 0.07981 0.06121 CTNS/DDAH2/ITGB2/TRAP1/STAT3/KLF4/JAK2/MTOR/PTX3/FOXO3 10 BP GO:0002833 positive regulation of response to biotic stimulus 6/819 45/18670 0.01325 0.08021 0.06152 MAPK3/PRKCA/GRN/IL12A/SASH1/UNC13B 6 BP GO:0038034 signal transduction in absence of ligand 8/819 72/18670 0.01332 0.08025 0.06154 UNC5B/BCL2L1/SNAI2/BAD/BCL2/PPP2R1A/CASP9/FOXO3 8 BP GO:0060193 positive regulation of lipase activity 8/819 72/18670 0.01332 0.08025 0.06154 ABHD5/NTRK2/ARF4/NR1H2/NR1H3/LPAR1/HTR2B/EDNRA 8 BP GO:0090114 COPII-coated vesicle budding 8/819 72/18670 0.01332 0.08025 0.06154 CTSC/GOSR2/NAPA/COL7A1/SEC13/SEC23B/LMAN1/TMED2 8 BP GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 8/819 72/18670 0.01332 0.08025 0.06154 UNC5B/BCL2L1/SNAI2/BAD/BCL2/PPP2R1A/CASP9/FOXO3 8 BP GO:0042476 odontogenesis 12/819 132/18670 0.01334 0.08025 0.06154 COL1A2/COL1A1/BMP4/LAMB1/FOXC1/MYO5A/TFAP2A/TGFB2/ITGA6/TNFRSF11B/TNC/TCIRG1 12 BP GO:0055007 cardiac muscle cell differentiation 12/819 132/18670 0.01334 0.08025 0.06154 GREM1/PIN1/FZD7/BMP4/MAML1/CAV3/ARRB2/RGS2/MTOR/MAP2K4/ITGB1/SORBS2 12 BP GO:0042180 cellular ketone metabolic process 19/819 248/18670 0.01336 0.08029 0.06157 OXCT1/PSMD8/LPGAT1/PSMB7/FDXR/HAGH/PSMD1/NR1H2/NR1H3/PSMB6/NMT1/PDK1/MTOR/COQ9/PDK2/PSMD3/TPI1/PSMD2/PSMB8 19 BP GO:0034765 regulation of ion transmembrane transport 32/819 483/18670 0.01372 0.08117 0.06225 GSTO1/SLC31A2/CLIC2/THBS1/CEMIP/EPHB2/CLIC1/GJA1/KCND3/HSPA2/SNTA1/MYO5A/PDE4B/GNB5/DIAPH1/ANXA3/CAV3/THY1/ATP1B1/RGS2/STAC/GRIN2B/GPD1L/MTOR/KCNMB1/CACNA1C/TCIRG1/BIN1/TRPC6/PER2/CLIC5/GRIN2A 32 BP GO:0018279 protein N-linked glycosylation via asparagine 5/819 33/18670 0.01373 0.08117 0.06225 ST6GAL1/UBE2J1/DPM2/LMAN1/STT3A 5 BP GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 5/819 33/18670 0.01373 0.08117 0.06225 NADK/OXCT1/ADCY8/HIF1A/BAD 5 BP GO:0042339 keratan sulfate metabolic process 5/819 33/18670 0.01373 0.08117 0.06225 SLC35D2/FMOD/B4GALT2/CHST2/ACAN 5 BP GO:0006554 lysine catabolic process 3/819 12/18670 0.01375 0.08117 0.06225 OGDH/ALDH7A1/CRYM 3 BP GO:0014889 muscle atrophy 3/819 12/18670 0.01375 0.08117 0.06225 GSN/MTOR/FOXO3 3 BP GO:0030208 dermatan sulfate biosynthetic process 3/819 12/18670 0.01375 0.08117 0.06225 BGN/VCAN/NCAN 3 BP GO:0031507 heterochromatin assembly 3/819 12/18670 0.01375 0.08117 0.06225 POLE3/HMGA1/CDKN2A 3 BP GO:0048484 enteric nervous system development 3/819 12/18670 0.01375 0.08117 0.06225 EDNRA/PHACTR4/HLX 3 BP GO:0060391 positive regulation of SMAD protein signal transduction 3/819 12/18670 0.01375 0.08117 0.06225 BMP4/TGFBR1/NUP93 3 BP GO:0060900 embryonic camera-type eye formation 3/819 12/18670 0.01375 0.08117 0.06225 TFAP2A/ALDH1A3/PHACTR4 3 BP GO:0090148 membrane fission 3/819 12/18670 0.01375 0.08117 0.06225 SH3GL2/MX1/MX2 3 BP GO:0097284 hepatocyte apoptotic process 3/819 12/18670 0.01375 0.08117 0.06225 BCL2L1/GSN/KRT18 3 BP GO:0099640 axo-dendritic protein transport 3/819 12/18670 0.01375 0.08117 0.06225 RAB27B/TERF2/MAP1A 3 BP GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 3/819 12/18670 0.01375 0.08117 0.06225 PLXND1/NRP1/PLXNC1 3 BP GO:1902337 regulation of apoptotic process involved in morphogenesis 3/819 12/18670 0.01375 0.08117 0.06225 VDR/FOXC1/TGFB2 3 BP GO:0007613 memory 11/819 117/18670 0.0138 0.08131 0.06236 CTNS/ADCY8/B4GALT2/ITPR3/ITGA3/MTOR/PLCB1/MAP1A/ASIC1/GRIN2A/VLDLR 11 BP GO:0051153 regulation of striated muscle cell differentiation 11/819 117/18670 0.0138 0.08131 0.06236 GREM1/PIN1/FZD7/BMP4/MAML1/CAV3/ARRB2/RGS2/IL4R/MTOR/BCL2 11 BP GO:0007159 leukocyte cell-cell adhesion 24/819 337/18670 0.01386 0.08157 0.06256 CD55/CXCL12/BMP4/PIK3R1/CD70/IL12A/ITGB2/TNFRSF14/HAS2/CD24/THY1/KLF4/SOCS5/IL6ST/IL4R/BAD/PTPN11/PAWR/SDC4/EZR/NCK1/ITGB1/HLX/HLA-DPB1 24 BP GO:0007626 locomotory behavior 16/819 198/18670 0.01394 0.08186 0.06278 NOVA1/CTNS/ADCY8/CXCL12/NAGLU/CHL1/B4GALT2/TMOD1/MYO5A/SPG11/EPS8/FIG4/ARRB2/GLRB/MTOR/ALDH1A3 16 BP GO:0002690 positive regulation of leukocyte chemotaxis 9/819 87/18670 0.01394 0.08186 0.06278 MAPK3/RARRES2/THBS4/THBS1/CXCL12/VEGFC/IL12A/CCR1/GAS6 9 BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 10/819 102/18670 0.01404 0.08237 0.06317 THBS1/SH3GL2/CAPZA2/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/HLA-DPB1 10 BP GO:0019216 regulation of lipid metabolic process 28/819 410/18670 0.01408 0.08248 0.06326 VDR/RARRES2/TM7SF2/IGFBP7/LPGAT1/ABCG1/ABHD5/PIK3R1/PRKD1/NR1H2/PIK3IP1/NR1H3/SNAI2/PDGFA/PIK3R2/PNPLA2/KLF4/PDK1/SOCS5/SOCS3/ASAH1/GLIPR1/MTOR/MBTPS1/HTR2B/PDK2/CREBBP/NFYB 28 BP GO:0001508 action potential 12/819 133/18670 0.0141 0.08253 0.06329 CLN3/ATP2A2/GJA1/NTRK2/GJC1/KCND3/SNTA1/CAV3/ATP1B1/GPD1L/CACNA1C/BIN1 12 BP GO:0000469 cleavage involved in rRNA processing 4/819 22/18670 0.0143 0.08281 0.06351 EXOSC7/RRS1/EXOSC2/NHP2 4 BP GO:0006582 melanin metabolic process 4/819 22/18670 0.0143 0.08281 0.06351 CTNS/MYO5A/TYR/BCL2 4 BP GO:0010869 regulation of receptor biosynthetic process 4/819 22/18670 0.0143 0.08281 0.06351 NR1H3/HIF1A/ITGB3/JAK2 4 BP GO:0032069 regulation of nuclease activity 4/819 22/18670 0.0143 0.08281 0.06351 OAS1/OAS2/TERF2/OASL 4 BP GO:0035024 negative regulation of Rho protein signal transduction 4/819 22/18670 0.0143 0.08281 0.06351 MYOC/MET/ITGA3/ITGB1 4 BP GO:0042359 vitamin D metabolic process 4/819 22/18670 0.0143 0.08281 0.06351 VDR/SNAI2/CYP3A4/CYP27A1 4 BP GO:0051195 negative regulation of cofactor metabolic process 4/819 22/18670 0.0143 0.08281 0.06351 CTNS/NUPR1/FBP1/STAT3 4 BP GO:0097205 renal filtration 4/819 22/18670 0.0143 0.08281 0.06351 GJA1/ITGA3/SULF1/GAS6 4 BP GO:0140112 extracellular vesicle biogenesis 4/819 22/18670 0.0143 0.08281 0.06351 STAM/CHMP2A/TSG101/SDC4 4 BP GO:0061077 chaperone-mediated protein folding 7/819 59/18670 0.01431 0.08281 0.06351 HSPA5/HSPA2/FKBP4/PPIB/TRAP1/DNAJB5/BAG1 7 BP GO:0070527 platelet aggregation 7/819 59/18670 0.01431 0.08281 0.06351 PRKCA/COMP/CLIC1/MYH9/ITGB3/PIK3CB/GAS6 7 BP GO:0048871 multicellular organismal homeostasis 32/819 485/18670 0.01449 0.08373 0.06422 NOVA1/ARNTL/IL18R1/PRCP/PLEKHM1/ACOT13/PRKCA/ADCY8/GJA1/CLDN4/FOXC1/ADCY7/NR1H2/WWTR1/NR1H3/HADH/MET/ITGB3/LIPA/HAS2/EPAS1/GRB10/STAT3/UCP2/JAK2/IL4R/TNFRSF11B/BCL2/TCIRG1/PTPN11/PER2/ZNF423 32 BP GO:0071354 cellular response to interleukin-6 6/819 46/18670 0.01468 0.08477 0.06501 STAT3/JAK2/IL6ST/SOCS3/PTPN11/PHB 6 BP GO:0048754 branching morphogenesis of an epithelial tube 13/819 150/18670 0.01489 0.08573 0.06575 VDR/KDM5B/MAGED1/BMP4/PLXND1/NRP1/MET/COL4A1/CAV3/LAMA1/BCL2/TNC/EDNRA 13 BP GO:0018210 peptidyl-threonine modification 12/819 134/18670 0.01489 0.08573 0.06575 CEMIP/PRKCA/TGFBR1/PRKD1/PRKCB/MTOR/BCL2/PPP2R5D/CHI3L1/TRPC6/PKN1/DYRK1B 12 BP GO:0034103 regulation of tissue remodeling 9/819 88/18670 0.01494 0.08573 0.06575 VDR/GREM1/THBS4/PLEKHM1/PRKCA/GJA1/ABR/ITGB3/TNFRSF11B 9 BP GO:1900407 regulation of cellular response to oxidative stress 9/819 88/18670 0.01494 0.08573 0.06575 PYCR1/TXN/HIF1A/MET/TRAP1/FBLN5/FZD1/PAWR/FOXO3 9 BP GO:1903725 regulation of phospholipid metabolic process 9/819 88/18670 0.01494 0.08573 0.06575 PIK3R1/PRKD1/PIK3IP1/PDGFA/PIK3R2/KLF4/SOCS5/SOCS3/HTR2B 9 BP GO:0018958 phenol-containing compound metabolic process 10/819 103/18670 0.01496 0.08573 0.06575 CTNS/ITGB2/MYO5A/TYR/FAH/EPAS1/TGFB2/BCL2/GRIN2A/CRYM 10 BP GO:0032091 negative regulation of protein binding 10/819 103/18670 0.01496 0.08573 0.06575 MAPK3/IFIT2/PIN1/HSPA5/ADAM15/IFIT1/MET/ARRB2/ITGB1BP1/CAMK1 10 BP GO:0008016 regulation of heart contraction 19/819 251/18670 0.01501 0.08579 0.06579 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/TPM1/SNTA1/PDE4B/ITPR3/EPAS1/CAV3/ATP1B1/TGFB2/RGS2/JAK2/GPD1L/CACNA1C/BIN1 19 BP GO:0021537 telencephalon development 19/819 251/18670 0.01501 0.08579 0.06579 COL3A1/CXCL12/EPHB2/BMP4/LAMB1/NTRK2/TACC2/NRP1/HIF1A/ANXA3/GNG12/GART/UQCRQ/EXT1/LPAR1/BAD/PLCB1/NRP2/ALDH1A3 19 BP GO:0009127 purine nucleoside monophosphate biosynthetic process 15/819 183/18670 0.01503 0.08579 0.06579 AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/SEC13/PGM1/TPI1 15 BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process 15/819 183/18670 0.01503 0.08579 0.06579 AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/SEC13/PGM1/TPI1 15 BP GO:1903037 regulation of leukocyte cell-cell adhesion 22/819 304/18670 0.01517 0.08649 0.06633 CD55/CXCL12/BMP4/PIK3R1/CD70/IL12A/ITGB2/TNFRSF14/HAS2/CD24/THY1/KLF4/SOCS5/IL6ST/IL4R/BAD/PTPN11/PAWR/SDC4/NCK1/HLX/HLA-DPB1 22 BP GO:0043624 cellular protein complex disassembly 17/819 217/18670 0.01524 0.08671 0.0665 MICAL2/SH3GL2/MRPL40/CIB1/TMOD1/CAPZA2/NAPA/GSN/TWF2/MRPL28/EPS8/CAMSAP2/SPTBN1/MAP1A/KIF2C/CKAP5/LMOD1 17 BP GO:0050920 regulation of chemotaxis 17/819 217/18670 0.01524 0.08671 0.0665 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/SCG2/VEGFC/PRKD1/IL12A/NRP1/MET/CCR1/BST1/GAS6/LPAR1/ITGA2 17 BP GO:0035051 cardiocyte differentiation 14/819 167/18670 0.01541 0.08758 0.06717 MAPK3/GREM1/PIN1/FZD7/BMP4/MAML1/CAV3/TGFB2/ARRB2/RGS2/MTOR/MAP2K4/ITGB1/SORBS2 14 BP GO:0051193 regulation of cofactor metabolic process 11/819 119/18670 0.01551 0.08774 0.06729 CTNS/NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/PDK2 11 BP GO:0018196 peptidyl-asparagine modification 5/819 34/18670 0.01553 0.08774 0.06729 ST6GAL1/UBE2J1/DPM2/LMAN1/STT3A 5 BP GO:0043276 anoikis 5/819 34/18670 0.01553 0.08774 0.06729 NTRK2/SNAI2/MTOR/BCL2/ITGB1 5 BP GO:0048048 embryonic eye morphogenesis 5/819 34/18670 0.01553 0.08774 0.06729 FBN2/TFAP2A/EFEMP1/ALDH1A3/PHACTR4 5 BP GO:0043507 positive regulation of JUN kinase activity 8/819 74/18670 0.01555 0.08774 0.06729 MAP3K4/SASH1/MDFIC/MAP3K5/MAP4K2/ROR2/MAP2K4/PKN1 8 BP GO:0048199 vesicle targeting, to, from or within Golgi 8/819 74/18670 0.01555 0.08774 0.06729 CTSC/GOSR2/NAPA/COL7A1/ARFGAP2/SEC13/LMAN1/TMED2 8 BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 8/819 74/18670 0.01555 0.08774 0.06729 PIN1/EMILIN1/EPHB2/RAPGEF1/KLF4/ITGB1BP1/PHB/EZR 8 BP GO:0033260 nuclear DNA replication 7/819 60/18670 0.01561 0.08797 0.06746 PRIM2/RFC3/POLE3/RPA3/TERF2/PRIM1/POLD2 7 BP GO:0007498 mesoderm development 12/819 135/18670 0.01571 0.08846 0.06784 BMP4/FOXC1/MEST/ITGB3/ITGA3/KLF4/JAK2/EXT1/WNT11/KDM6A/ITGA2/ITGB1 12 BP GO:0046777 protein autophosphorylation 18/819 235/18670 0.01578 0.08874 0.06806 MAPK3/ENPP1/GREM1/MAPKAPK3/NTRK2/VEGFC/PRKD1/IQGAP1/RASSF2/EPHB4/PDGFA/THY1/DDR2/JAK2/MTOR/PPP2R5D/DYRK1B/PRKX 18 BP GO:0010001 glial cell differentiation 17/819 218/18670 0.01588 0.08905 0.06829 MAPK3/MYOC/GRN/GAP43/NTRK2/PLP1/GSN/TSPAN2/STAT3/IL6ST/LPAR1/MTOR/ROR2/BIN1/PTPN11/SOX4/NAB1 17 BP GO:0019722 calcium-mediated signaling 17/819 218/18670 0.01588 0.08905 0.06829 GSTO1/CLIC2/CCRL2/ATP2A2/CIB1/MYO5A/CCR3/DEFB1/CCR1/BST1/ATP1B1/GRIN2B/MTOR/CACNA1C/HTR2B/PDK2/GRIN2A 17 BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 17/819 218/18670 0.01588 0.08905 0.06829 CD55/PIK3R1/CD70/IL12A/ITGB2/TNFRSF14/HAS2/CD24/THY1/SOCS5/IL6ST/IL4R/BAD/PTPN11/NCK1/HLX/HLA-DPB1 17 BP GO:0001523 retinoid metabolic process 10/819 104/18670 0.01592 0.08919 0.0684 RARRES2/CYP1B1/ADH1C/HSPG2/CYP3A4/ADH1A/ADH1B/GPC4/ALDH1A3/SDC4 10 BP GO:0060021 roof of mouth development 9/819 89/18670 0.016 0.08942 0.06858 SATB2/EPHB2/TGFBR1/FZD2/SNAI2/TFAP2A/TGFB2/WNT11/FZD1 9 BP GO:1901019 regulation of calcium ion transmembrane transporter activity 9/819 89/18670 0.016 0.08942 0.06858 GSTO1/CLIC2/HSPA2/MYO5A/PDE4B/GNB5/CAV3/ATP1B1/STAC 9 BP GO:0030574 collagen catabolic process 6/819 47/18670 0.01623 0.09022 0.06919 ADAM15/FAP/MRC2/COL15A1/MMP17/ITGB1 6 BP GO:0045646 regulation of erythrocyte differentiation 6/819 47/18670 0.01623 0.09022 0.06919 ISG15/HIF1A/PRMT1/STAT3/ZFP36/FOXO3 6 BP GO:0060351 cartilage development involved in endochondral bone morphogenesis 6/819 47/18670 0.01623 0.09022 0.06919 COL1A1/SERPINH1/COMP/COL14A1/COL6A3/COL7A1 6 BP GO:0061383 trabecula morphogenesis 6/819 47/18670 0.01623 0.09022 0.06919 GREM1/COL1A1/TGFBR1/FBN2/CAV3/TGFB2 6 BP GO:1900744 regulation of p38MAPK cascade 6/819 47/18670 0.01623 0.09022 0.06919 MAP3K4/SASH1/MAP3K5/PRMT1/CAV3/EZR 6 BP GO:1904062 regulation of cation transmembrane transport 24/819 342/18670 0.0163 0.09055 0.06945 GSTO1/SLC31A2/CLIC2/CEMIP/EPHB2/HSPA2/SNTA1/MYO5A/PDE4B/GNB5/DIAPH1/ANXA3/CAV3/THY1/ATP1B1/RGS2/STAC/GRIN2B/GPD1L/KCNMB1/CACNA1C/TCIRG1/BIN1/GRIN2A 24 BP GO:0016202 regulation of striated muscle tissue development 13/819 152/18670 0.01646 0.09134 0.07005 GREM1/ARNTL/PIN1/FZD7/BMP4/GJA1/TGFBR1/LOX/CAV3/ARRB2/RGS2/MTOR/BCL2 13 BP GO:0042391 regulation of membrane potential 29/819 434/18670 0.01653 0.09163 0.07027 PYCR1/CTNS/MYOC/CLN3/ATP2A2/CLIC1/GJA1/NTRK2/GJC1/BCL2L1/KCND3/SNTA1/KCNN4/GCLM/CAV3/ATP1B1/ARRB2/GABBR1/GLRB/GRIN2B/GPD1L/UNC13B/BAD/BCL2/CACNA1C/BIN1/HEBP2/ASIC1/GRIN2A 29 BP GO:0006575 cellular modified amino acid metabolic process 16/819 202/18670 0.01657 0.09174 0.07036 CTNS/GGT5/MTHFD2/HAGH/GGCT/FOLR2/P4HA1/CKB/SERINC5/GCLM/GART/GPX4/MTHFD1/CKMT2/ALDH7A1/CRYM 16 BP GO:0010499 proteasomal ubiquitin-independent protein catabolic process 4/819 23/18670 0.01673 0.0919 0.07048 PSMB7/ENC1/PSMB6/PSMB8 4 BP GO:0032373 positive regulation of sterol transport 4/819 23/18670 0.01673 0.0919 0.07048 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0032376 positive regulation of cholesterol transport 4/819 23/18670 0.01673 0.0919 0.07048 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0051004 regulation of lipoprotein lipase activity 4/819 23/18670 0.01673 0.0919 0.07048 PCSK5/ABHD5/NR1H2/NR1H3 4 BP GO:1901032 negative regulation of response to reactive oxygen species 4/819 23/18670 0.01673 0.0919 0.07048 PYCR1/TXN/MET/TRAP1 4 BP GO:1903206 negative regulation of hydrogen peroxide-induced cell death 4/819 23/18670 0.01673 0.0919 0.07048 PYCR1/TXN/MET/TRAP1 4 BP GO:2001039 negative regulation of cellular response to drug 4/819 23/18670 0.01673 0.0919 0.07048 PYCR1/TXN/MET/TRAP1 4 BP GO:0010948 negative regulation of cell cycle process 25/819 361/18670 0.01676 0.0919 0.07048 ESPL1/NACC2/PSMD8/PSMB7/BMP4/YAF2/PSMD1/KAT2B/PSMB6/PRMT1/KLF4/SYF2/TERF2/CHMP2A/RRM2/BCL2/ANAPC15/PSMD3/SOX4/RYBP/IK/CTDSP2/PSMD2/PSMB8/CDKN2A 25 BP GO:1903201 regulation of oxidative stress-induced cell death 8/819 75/18670 0.01676 0.0919 0.07048 PYCR1/TXN/HIF1A/MET/TRAP1/FZD1/PAWR/FOXO3 8 BP GO:0001558 regulation of cell growth 28/819 416/18670 0.01676 0.0919 0.07048 ENPP1/KAZALD1/IGFBP7/CRYAB/PIN1/CXCL12/GJA1/TGFBR1/IGFBP1/ADAM15/CIB1/ADNP2/FBP1/NRP1/NDUFS3/TWF2/CAV3/TGFB2/RGS2/WNT11/EXOSC2/MTOR/TSG101/BCL2/FBLN5/PPP2R1A/PHB/CDKN2A 28 BP GO:0007009 plasma membrane organization 10/819 105/18670 0.01693 0.09238 0.07085 MTSS1/SH3GL2/ATP2A2/MYH9/GSN/CAV3/TGFB2/PLEKHM2/BIN1/SPTBN1 10 BP GO:0008593 regulation of Notch signaling pathway 10/819 105/18670 0.01693 0.09238 0.07085 POSTN/MAML1/KAT2B/DLK1/STAT3/TGFB2/NOTCH3/ITGB1BP1/IL6ST/CREBBP 10 BP GO:0055017 cardiac muscle tissue growth 10/819 105/18670 0.01693 0.09238 0.07085 PIN1/GJA1/TGFBR1/FOXC1/CAV3/TGFB2/RGS2/MTOR/MAP2K4/SORBS2 10 BP GO:0015698 inorganic anion transport 14/819 169/18670 0.01694 0.09238 0.07085 ENPP1/SFRP4/CLIC2/SLC4A4/SLC20A1/CLIC1/CLDN4/SLC4A3/MFSD5/CLCN7/GLRB/MTOR/CLCN6/CLIC5 14 BP GO:0003170 heart valve development 7/819 61/18670 0.01699 0.09238 0.07085 EMILIN1/BMP4/ELN/SNAI2/TGFB2/MTOR/SOX4 7 BP GO:0007040 lysosome organization 7/819 61/18670 0.01699 0.09238 0.07085 CLN3/HPS1/NAGLU/GRN/LYST/SPG11/MBTPS1 7 BP GO:0080171 lytic vacuole organization 7/819 61/18670 0.01699 0.09238 0.07085 CLN3/HPS1/NAGLU/GRN/LYST/SPG11/MBTPS1 7 BP GO:1903902 positive regulation of viral life cycle 7/819 61/18670 0.01699 0.09238 0.07085 RAD23A/ADARB1/ADAR/IFIT1/PPIB/CHMP2A/TSG101 7 BP GO:0030308 negative regulation of cell growth 15/819 186/18670 0.0172 0.09249 0.07093 ENPP1/CRYAB/GJA1/ADAM15/FBP1/NRP1/NDUFS3/CAV3/TGFB2/RGS2/WNT11/BCL2/PPP2R1A/PHB/CDKN2A 15 BP GO:0003015 heart process 21/819 290/18670 0.01728 0.09249 0.07093 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/WWTR1/TPM1/SNTA1/PDE4B/ITPR3/EPAS1/CAV3/ATP1B1/TGFB2/RGS2/JAK2/GPD1L/MTOR/CACNA1C/BIN1 21 BP GO:0000212 meiotic spindle organization 3/819 13/18670 0.0173 0.09249 0.07093 ESPL1/MYH9/PPP2R1A 3 BP GO:0006553 lysine metabolic process 3/819 13/18670 0.0173 0.09249 0.07093 OGDH/ALDH7A1/CRYM 3 BP GO:0010839 negative regulation of keratinocyte proliferation 3/819 13/18670 0.0173 0.09249 0.07093 VDR/SNAI2/PTPRK 3 BP GO:0010870 positive regulation of receptor biosynthetic process 3/819 13/18670 0.0173 0.09249 0.07093 NR1H3/HIF1A/JAK2 3 BP GO:0014842 regulation of skeletal muscle satellite cell proliferation 3/819 13/18670 0.0173 0.09249 0.07093 ANGPT1/STAT3/JAK2 3 BP GO:0016024 CDP-diacylglycerol biosynthetic process 3/819 13/18670 0.0173 0.09249 0.07093 CDS1/CDS2/AGPAT1 3 BP GO:0021554 optic nerve development 3/819 13/18670 0.0173 0.09249 0.07093 EPHB2/LPAR1/TCIRG1 3 BP GO:0030205 dermatan sulfate metabolic process 3/819 13/18670 0.0173 0.09249 0.07093 BGN/VCAN/NCAN 3 BP GO:0043201 response to leucine 3/819 13/18670 0.0173 0.09249 0.07093 RRAGD/PIK3C3/MTOR 3 BP GO:0045820 negative regulation of glycolytic process 3/819 13/18670 0.0173 0.09249 0.07093 NUPR1/FBP1/STAT3 3 BP GO:0061430 bone trabecula morphogenesis 3/819 13/18670 0.0173 0.09249 0.07093 GREM1/COL1A1/FBN2 3 BP GO:0070831 basement membrane assembly 3/819 13/18670 0.0173 0.09249 0.07093 PXDN/RAMP2/LAMB1 3 BP GO:0090179 planar cell polarity pathway involved in neural tube closure 3/819 13/18670 0.0173 0.09249 0.07093 PTK7/FZD2/FZD1 3 BP GO:1902430 negative regulation of amyloid-beta formation 3/819 13/18670 0.0173 0.09249 0.07093 PIN1/SPON1/BIN1 3 BP GO:1903960 negative regulation of anion transmembrane transport 3/819 13/18670 0.0173 0.09249 0.07093 THBS1/RGS2/MTOR 3 BP GO:0030968 endoplasmic reticulum unfolded protein response 11/819 121/18670 0.01738 0.09284 0.0712 STC2/CREB3L2/KDELR3/ATP6V0D1/PIK3R1/IGFBP1/HSPA5/GOSR2/MBTPS1/CTDSP2/NCK1 11 BP GO:0001893 maternal placenta development 5/819 35/18670 0.01748 0.09321 0.07148 MAPK3/VDR/STC2/GJA1/TMED2 5 BP GO:0045070 positive regulation of viral genome replication 5/819 35/18670 0.01748 0.09321 0.07148 RAD23A/ADARB1/ADAR/IFIT1/PPIB 5 BP GO:0008542 visual learning 6/819 48/18670 0.01788 0.09512 0.07295 CTNS/B4GALT2/HIF1A/MTOR/GRIN2A/ITGB1 6 BP GO:0046850 regulation of bone remodeling 6/819 48/18670 0.01788 0.09512 0.07295 GREM1/PLEKHM1/PRKCA/GJA1/ITGB3/TNFRSF11B 6 BP GO:0060249 anatomical structure homeostasis 29/819 437/18670 0.01797 0.09535 0.07313 MAPK3/MAP3K4/PLEKHM1/PRKCA/PRIM2/FOXC1/RFC3/WWTR1/POLE3/LOX/XRCC6/SMC5/HIF1A/ITGB3/LIPA/RPA3/EPAS1/CAV3/NEK7/TERF2/PRIM1/NHP2/TNFRSF11B/BCL2/CCT7/TCIRG1/MAP1A/PTPN11/POLD2 29 BP GO:0003300 cardiac muscle hypertrophy 10/819 106/18670 0.01799 0.09535 0.07313 PIN1/PRKCA/ATP2A2/CAV3/RGS2/IL6ST/MTOR/MAP2K4/HTR2B/SORBS2 10 BP GO:0007041 lysosomal transport 10/819 106/18670 0.01799 0.09535 0.07313 DENND3/VPS41/TRAK2/GRN/LYST/VPS11/CLEC16A/SNX27/TSG101/BIN1 10 BP GO:1901606 alpha-amino acid catabolic process 10/819 106/18670 0.01799 0.09535 0.07313 PCBD1/HMGCL/DDAH2/OGDH/QDPR/AUH/FAH/ALDH7A1/CRYM/BCAT2 10 BP GO:0046785 microtubule polymerization 8/819 76/18670 0.01804 0.09552 0.07326 FKBP4/MET/ARL2/MAPRE3/CAV3/CLIP1/CAMSAP2/CKAP5 8 BP GO:0009100 glycoprotein metabolic process 28/819 419/18670 0.01825 0.09656 0.07406 BGN/ST3GAL5/NDST1/CHST7/CHSY1/TRAK2/TCF7L2/COL11A1/SEL1L/ST6GALNAC2/B4GALT2/ITM2B/IDS/HIF1A/ST6GAL1/UBE2J1/SULF1/EXT1/DPM2/BCL2/PLCB1/ACAN/PTX3/VCAN/PAWR/LMAN1/NCAN/STT3A 28 BP GO:0045639 positive regulation of myeloid cell differentiation 9/819 91/18670 0.01828 0.09658 0.07407 PRKCA/ISG15/HAX1/HIF1A/PRMT1/CCR1/STAT3/ROR2/FOXO3 9 BP GO:0043500 muscle adaptation 11/819 122/18670 0.01837 0.09691 0.07432 MYOC/PIN1/PRKCA/ATP2A2/GSN/CAV3/KLF4/RGS2/IL6ST/MTOR/FOXO3 11 BP GO:1903409 reactive oxygen species biosynthetic process 11/819 122/18670 0.01837 0.09691 0.07432 CTNS/CYP1B1/DDAH2/ITGB2/TRAP1/STAT3/KLF4/JAK2/MTOR/PTX3/FOXO3 11 BP GO:0046631 alpha-beta T cell activation 12/819 138/18670 0.01839 0.09693 0.07434 CD55/IL18R1/IL12A/TNFRSF14/STAT3/RSAD2/SOCS5/IL4R/MTOR/BCL2/TCIRG1/HLX 12 BP GO:0006521 regulation of cellular amino acid metabolic process 7/819 62/18670 0.01845 0.09703 0.07441 PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 7 BP GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 7/819 62/18670 0.01845 0.09703 0.07441 GREM1/PIN1/EMILIN1/BMP4/TGFBR1/INHBB/TGFB2 7 BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process 14/819 171/18670 0.01857 0.09749 0.07477 NME3/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/COX5B/STAT3/SEC13/PGM1/TPI1 14 BP GO:0060401 cytosolic calcium ion transport 14/819 171/18670 0.01857 0.09749 0.07477 GSTO1/CLIC2/CEMIP/ATP2A2/MYO5A/DIAPH1/ITPR3/THY1/GRIN2B/BCL2/PLCB1/CACNA1C/HTR2B/GRIN2A 14 BP GO:1901292 nucleoside phosphate catabolic process 15/819 188/18670 0.01876 0.0984 0.07547 ENPP1/OGDH/NUPR1/MBD4/LDHA/FBP1/PDE4B/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 15 BP GO:0019932 second-messenger-mediated signaling 29/819 439/18670 0.01898 0.09945 0.07627 GSTO1/CLIC2/FPR1/THBS1/PRKCA/ADCY8/CCRL2/ATP2A2/RAMP2/DDAH2/RUNDC3A/ADCY7/CIB1/MYO5A/CCR3/DEFB1/ITPR3/CCR1/BST1/ATP1B1/RGS2/GRIN2B/LPAR1/MTOR/CACNA1C/HTR2B/PPP2R1A/PDK2/GRIN2A 29 BP GO:0060968 regulation of gene silencing 13/819 155/18670 0.01906 0.09964 0.07642 POLR2L/POLR2E/BMP4/PHF2/ADAR/NUP205/NUP93/NUP153/STAT3/ZFP36/SEC13/ASF1A/HMGA1 13 BP GO:1901861 regulation of muscle tissue development 13/819 155/18670 0.01906 0.09964 0.07642 GREM1/ARNTL/PIN1/FZD7/BMP4/GJA1/TGFBR1/LOX/CAV3/ARRB2/RGS2/MTOR/BCL2 13 BP GO:0043502 regulation of muscle adaptation 10/819 107/18670 0.01909 0.09974 0.07649 PIN1/PRKCA/ATP2A2/CAV3/KLF4/RGS2/IL6ST/MTOR/SGCA/FOXO3 10 BP GO:0033135 regulation of peptidyl-serine phosphorylation 12/819 139/18670 0.01936 0.1 0.07672 TXN/ANGPT1/NTRK2/PRKD1/RASSF2/HAX1/ARRB2/GAS6/GPD1L/BCL2/NCK1/CAMK1 12 BP GO:0002092 positive regulation of receptor internalization 4/819 24/18670 0.01939 0.1 0.07672 SFRP4/GREM1/ANGPT1/ARRB2 4 BP GO:0003433 chondrocyte development involved in endochondral bone morphogenesis 4/819 24/18670 0.01939 0.1 0.07672 SERPINH1/COL14A1/COL6A3/COL7A1 4 BP GO:0034629 cellular protein-containing complex localization 4/819 24/18670 0.01939 0.1 0.07672 NACC2/KLHL21/EXOC3/EZR 4 BP GO:0046174 polyol catabolic process 4/819 24/18670 0.01939 0.1 0.07672 SYNJ2/SORD/INPP5E/TPI1 4 BP GO:0046697 decidualization 4/819 24/18670 0.01939 0.1 0.07672 MAPK3/VDR/STC2/GJA1 4 BP GO:0060343 trabecula formation 4/819 24/18670 0.01939 0.1 0.07672 GREM1/COL1A1/FBN2/CAV3 4 BP GO:0060396 growth hormone receptor signaling pathway 4/819 24/18670 0.01939 0.1 0.07672 PIK3R1/GHR/STAT3/JAK2 4 BP GO:0062009 secondary palate development 4/819 24/18670 0.01939 0.1 0.07672 FZD2/TGFB2/WNT11/FZD1 4 BP GO:0086064 cell communication by electrical coupling involved in cardiac conduction 4/819 24/18670 0.01939 0.1 0.07672 GJA1/GJC1/ATP1B1/CACNA1C 4 BP GO:1901071 glucosamine-containing compound metabolic process 4/819 24/18670 0.01939 0.1 0.07672 RENBP/CHST7/CHST2/GNPDA1 4 BP GO:1903649 regulation of cytoplasmic transport 4/819 24/18670 0.01939 0.1 0.07672 MAPK3/VPS11/RAB29/EZR 4 BP GO:2000209 regulation of anoikis 4/819 24/18670 0.01939 0.1 0.07672 NTRK2/SNAI2/BCL2/ITGB1 4 BP GO:0051928 positive regulation of calcium ion transport 11/819 123/18670 0.01941 0.1 0.07672 GSTO1/CEMIP/CXCL12/HSPA2/MYLK/CCR1/THY1/ATP1B1/ARRB2/STAC/TRPC6 11 BP GO:0009145 purine nucleoside triphosphate biosynthetic process 14/819 172/18670 0.01944 0.1001 0.07676 NME3/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/COX5B/STAT3/SEC13/PGM1/TPI1 14 BP GO:0009112 nucleobase metabolic process 5/819 36/18670 0.01959 0.1005 0.07705 GART/MTHFD1/MTOR/GMPR/CTPS1 5 BP GO:0046627 negative regulation of insulin receptor signaling pathway 5/819 36/18670 0.01959 0.1005 0.07705 ENPP1/GRB10/PRKCB/SOCS3/NCK1 5 BP GO:0051973 positive regulation of telomerase activity 5/819 36/18670 0.01959 0.1005 0.07705 MAPK3/GREM1/MAP3K4/NEK7/KLF4 5 BP GO:0003254 regulation of membrane depolarization 6/819 49/18670 0.01964 0.1005 0.07705 MYOC/GJA1/GCLM/CAV3/GPD1L/BCL2 6 BP GO:0010712 regulation of collagen metabolic process 6/819 49/18670 0.01964 0.1005 0.07705 EMILIN1/BMP4/FAP/ARRB2/ITGA2/ITGB1 6 BP GO:1903018 regulation of glycoprotein metabolic process 6/819 49/18670 0.01964 0.1005 0.07705 TCF7L2/ITM2B/BCL2/PLCB1/PTX3/PAWR 6 BP GO:1990090 cellular response to nerve growth factor stimulus 6/819 49/18670 0.01964 0.1005 0.07705 SH3GL2/NTRK2/HSPA5/CIB1/RAPGEF1/FOXO3 6 BP GO:0048634 regulation of muscle organ development 13/819 156/18670 0.01999 0.102 0.07823 GREM1/ARNTL/PIN1/FZD7/BMP4/GJA1/TGFBR1/LOX/CAV3/ARRB2/RGS2/MTOR/BCL2 13 BP GO:0042982 amyloid precursor protein metabolic process 7/819 63/18670 0.02 0.102 0.07823 CLN3/PIN1/ABCG1/ITM2B/SPON1/BIN1/PAWR 7 BP GO:0045815 positive regulation of gene expression, epigenetic 7/819 63/18670 0.02 0.102 0.07823 POLR2L/POLR2E/PHF2/KAT2B/WBP2/ASF1A/HMGA1 7 BP GO:0030595 leukocyte chemotaxis 17/819 224/18670 0.02017 0.1027 0.07879 MAPK3/GREM1/RARRES2/THBS4/THBS1/CXCL12/ITGA1/SCG2/VEGFC/IL12A/ITGB2/LYST/PDE4B/CCR1/BST1/TGFB2/GAS6 17 BP GO:0090257 regulation of muscle system process 19/819 259/18670 0.02018 0.1027 0.07879 GSTO1/CLIC2/PIN1/PRKCA/ATP2A2/TPM1/PDE4B/CAV3/ATP1B1/KLF4/RGS2/IL6ST/MTOR/SGCA/CACNA1C/CNN1/ITGA2/BIN1/FOXO3 19 BP GO:2000146 negative regulation of cell motility 24/819 349/18670 0.02028 0.1031 0.07906 COL3A1/GREM1/IDH2/THBS1/CYP1B1/PIN1/CXCL12/EMILIN1/ADARB1/MCC/ADAM15/DPYSL3/ABR/TPM1/PTPRK/THY1/STAT3/KLF4/ITGB1BP1/SULF1/WNT11/BCL2/PLCB1/FOXO3 24 BP GO:0043087 regulation of GTPase activity 31/819 479/18670 0.02028 0.1031 0.07906 RANGAP1/PIN1/TBC1D4/NTRK2/PLXND1/ABR/IQGAP1/NRP1/GNB5/CHN1/ARL2/RAPGEF1/THY1/ARHGEF15/RASA1/ARRB2/ITGB1BP1/RGS2/PLXNC1/ITGA6/ARFGAP2/WNT11/MTOR/PLCB1/HTR2B/RABGAP1L/SEC23B/PIP5K1A/AGFG1/TMED2/ITGB1 31 BP GO:0034620 cellular response to unfolded protein 12/819 140/18670 0.02036 0.1032 0.07915 STC2/CREB3L2/KDELR3/ATP6V0D1/PIK3R1/IGFBP1/HSPA5/HSPA2/GOSR2/MBTPS1/CTDSP2/NCK1 12 BP GO:0035023 regulation of Rho protein signal transduction 12/819 140/18670 0.02036 0.1032 0.07915 COL3A1/MYOC/ARHGEF17/MCF2L/ABR/NRP1/MET/ITGA3/EPS8/ARHGEF15/LPAR1/ITGB1 12 BP GO:0097553 calcium ion transmembrane import into cytosol 12/819 140/18670 0.02036 0.1032 0.07915 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/GRIN2B/PLCB1/CACNA1C/HTR2B/GRIN2A 12 BP GO:0006903 vesicle targeting 9/819 93/18670 0.02078 0.1052 0.08068 CTSC/GOSR2/NAPA/COL7A1/MAP4K2/ARFGAP2/SEC13/LMAN1/TMED2 9 BP GO:0042246 tissue regeneration 8/819 78/18670 0.0208 0.1052 0.08069 POSTN/FZD7/GAP43/GJA1/IGFBP1/ADAM15/GSN/SGCA 8 BP GO:1905952 regulation of lipid localization 13/819 157/18670 0.02095 0.1059 0.0812 ATP8A1/THBS1/KDM5B/ABCG1/ABHD5/NR1H2/NR1H3/MEST/PLTP/ITGB3/PNPLA2/PTPN11/TMF1 13 BP GO:0009124 nucleoside monophosphate biosynthetic process 16/819 208/18670 0.02121 0.1066 0.08176 AK1/OGDH/NUPR1/LDHA/FBP1/TK2/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/SEC13/PGM1/TPI1 16 BP GO:0006999 nuclear pore organization 3/819 14/18670 0.02131 0.1066 0.08176 NUP205/NUP93/NUP153 3 BP GO:0014841 skeletal muscle satellite cell proliferation 3/819 14/18670 0.02131 0.1066 0.08176 ANGPT1/STAT3/JAK2 3 BP GO:0014857 regulation of skeletal muscle cell proliferation 3/819 14/18670 0.02131 0.1066 0.08176 ANGPT1/STAT3/JAK2 3 BP GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 3/819 14/18670 0.02131 0.1066 0.08176 HIP1R/LOX/PDGFA 3 BP GO:0045064 T-helper 2 cell differentiation 3/819 14/18670 0.02131 0.1066 0.08176 SOCS5/IL4R/HLX 3 BP GO:0046341 CDP-diacylglycerol metabolic process 3/819 14/18670 0.02131 0.1066 0.08176 CDS1/CDS2/AGPAT1 3 BP GO:0050930 induction of positive chemotaxis 3/819 14/18670 0.02131 0.1066 0.08176 CXCL12/SCG2/VEGFC 3 BP GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway 3/819 14/18670 0.02131 0.1066 0.08176 GHR/STAT3/JAK2 3 BP GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 3/819 14/18670 0.02131 0.1066 0.08176 PTK7/FZD2/FZD1 3 BP GO:1904748 regulation of apoptotic process involved in development 3/819 14/18670 0.02131 0.1066 0.08176 VDR/FOXC1/TGFB2 3 BP GO:0051149 positive regulation of muscle cell differentiation 10/819 109/18670 0.02145 0.1071 0.08214 GREM1/PIN1/BMP4/MAML1/CAV3/ARRB2/IL4R/MTOR/BCL2/CAMK1 10 BP GO:0072009 nephron epithelium development 10/819 109/18670 0.02145 0.1071 0.08214 MTSS1/MAGED1/BMP4/FOXC1/WWTR1/IQGAP1/PODXL/CD24/WNT11/BCL2 10 BP GO:0002931 response to ischemia 6/819 50/18670 0.02152 0.1072 0.08225 GJA1/CIB1/MAP3K5/BCL2/PER2/CASP9 6 BP GO:0033059 cellular pigmentation 6/819 50/18670 0.02152 0.1072 0.08225 HPS1/RAB32/RAB27B/LYST/MYO5A/BCL2 6 BP GO:0043550 regulation of lipid kinase activity 7/819 64/18670 0.02163 0.1075 0.08246 PIK3R1/PRKD1/PIK3IP1/PIK3R2/KLF4/SOCS5/SOCS3 7 BP GO:0045669 positive regulation of osteoblast differentiation 7/819 64/18670 0.02163 0.1075 0.08246 BMP4/CLIC1/PRKD1/FBN2/DDR2/IL6ST/PDLIM7 7 BP GO:2000378 negative regulation of reactive oxygen species metabolic process 7/819 64/18670 0.02163 0.1075 0.08246 CTNS/CRYAB/TFAP2A/HIF1A/TRAP1/STAT3/BCL2 7 BP GO:0034405 response to fluid shear stress 5/819 37/18670 0.02186 0.1085 0.08317 MTSS1/GJA1/HAS2/KLF4/SOCS5 5 BP GO:1905314 semi-lunar valve development 5/819 37/18670 0.02186 0.1085 0.08317 EMILIN1/BMP4/ELN/SNAI2/TGFB2 5 BP GO:0060402 calcium ion transport into cytosol 13/819 158/18670 0.02195 0.1087 0.08338 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/GRIN2B/BCL2/PLCB1/CACNA1C/HTR2B/GRIN2A 13 BP GO:0032535 regulation of cellular component size 25/819 370/18670 0.02195 0.1087 0.08338 HIP1R/CXCL12/ELN/CDC42EP1/LAMTOR5/NRP1/TMOD1/CAPZA2/HAX1/ARPC1B/GSN/TWF2/KCNN4/EPS8/CAV3/RASA1/MTOR/CLCN6/BIN1/SPTBN1/EZR/GMFG/RHOBTB2/LMOD1/NCK1 25 BP GO:0032200 telomere organization 14/819 175/18670 0.0222 0.1091 0.08366 MAPK3/MAP3K4/PRIM2/RFC3/POLE3/XRCC6/SMC5/RPA3/NEK7/TERF2/PRIM1/NHP2/CCT7/POLD2 14 BP GO:0006110 regulation of glycolytic process 8/819 79/18670 0.02229 0.1091 0.08366 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13 8 BP GO:0043536 positive regulation of blood vessel endothelial cell migration 8/819 79/18670 0.02229 0.1091 0.08366 THBS1/PRKCA/ANGPT1/VEGFC/PRKD1/CIB1/NRP1/HIF1A 8 BP GO:0002068 glandular epithelial cell development 4/819 25/18670 0.02231 0.1091 0.08366 ARNTL/RFX3/BMP4/BAD 4 BP GO:0003309 type B pancreatic cell differentiation 4/819 25/18670 0.02231 0.1091 0.08366 ARNTL/RFX3/BMP4/BAD 4 BP GO:0021680 cerebellar Purkinje cell layer development 4/819 25/18670 0.02231 0.1091 0.08366 NAGLU/B4GALT2/HSPA5/UQCRQ 4 BP GO:0048103 somatic stem cell division 4/819 25/18670 0.02231 0.1091 0.08366 FZD7/SOX5/TEAD3/TGFB2 4 BP GO:0050927 positive regulation of positive chemotaxis 4/819 25/18670 0.02231 0.1091 0.08366 CXCL12/SCG2/VEGFC/ITGA2 4 BP GO:0060330 regulation of response to interferon-gamma 4/819 25/18670 0.02231 0.1091 0.08366 NR1H2/NR1H3/JAK2/SOCS3 4 BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 4/819 25/18670 0.02231 0.1091 0.08366 NR1H2/NR1H3/JAK2/SOCS3 4 BP GO:0060561 apoptotic process involved in morphogenesis 4/819 25/18670 0.02231 0.1091 0.08366 VDR/CRYAB/FOXC1/TGFB2 4 BP GO:0061050 regulation of cell growth involved in cardiac muscle cell development 4/819 25/18670 0.02231 0.1091 0.08366 PIN1/CAV3/RGS2/MTOR 4 BP GO:0071378 cellular response to growth hormone stimulus 4/819 25/18670 0.02231 0.1091 0.08366 PIK3R1/GHR/STAT3/JAK2 4 BP GO:0072012 glomerulus vasculature development 4/819 25/18670 0.02231 0.1091 0.08366 BMP4/ANGPT1/NOTCH3/ACTA2 4 BP GO:0030336 negative regulation of cell migration 23/819 334/18670 0.0224 0.1094 0.08393 COL3A1/GREM1/IDH2/THBS1/CYP1B1/CXCL12/EMILIN1/ADARB1/MCC/ADAM15/DPYSL3/ABR/TPM1/PTPRK/THY1/STAT3/KLF4/ITGB1BP1/SULF1/WNT11/BCL2/PLCB1/FOXO3 23 BP GO:0050808 synapse organization 27/819 408/18670 0.02254 0.11 0.0844 ACTN1/TPBG/SPARC/PIN1/EPHB2/IL1RAP/GAP43/NTRK2/PLXND1/ARF4/NRP1/MYO5A/SPARCL1/GPC4/ITGA3/COL4A1/PALM/ARHGEF15/PDZRN3/GLRB/GRIN2B/RAB29/UNC13B/TNC/NRP2/FZD1/CAMK1 27 BP GO:0060047 heart contraction 20/819 280/18670 0.02257 0.1101 0.08441 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/TPM1/SNTA1/PDE4B/ITPR3/EPAS1/CAV3/ATP1B1/TGFB2/RGS2/JAK2/GPD1L/MTOR/CACNA1C/BIN1 20 BP GO:0006939 smooth muscle contraction 10/819 110/18670 0.0227 0.1105 0.08476 COMP/MYLK/SMTN/SULF1/RGS2/HTR2B/CNN1/EDNRA/ITGA2/ACTA2 10 BP GO:0016101 diterpenoid metabolic process 10/819 110/18670 0.0227 0.1105 0.08476 RARRES2/CYP1B1/ADH1C/HSPG2/CYP3A4/ADH1A/ADH1B/GPC4/ALDH1A3/SDC4 10 BP GO:0045667 regulation of osteoblast differentiation 11/819 126/18670 0.02277 0.1107 0.08487 GREM1/BMP4/CLIC1/PRKD1/RASSF2/FBN2/SNAI2/DDR2/IL6ST/TCIRG1/PDLIM7 11 BP GO:0048706 embryonic skeletal system development 11/819 126/18670 0.02277 0.1107 0.08487 SATB2/PCSK5/COL11A1/COL1A1/BMP4/TGFBR1/TFAP2A/SULF1/EXT1/WNT11/MTHFD1 11 BP GO:0014706 striated muscle tissue development 26/819 390/18670 0.02292 0.1113 0.08534 GREM1/ARNTL/COL11A1/PIN1/FZD7/BMP4/MAML1/GJA1/TGFBR1/FOXC1/ELN/GJC1/NUPR1/TPM1/LOX/FLNB/CAV3/TGFB2/ARRB2/RGS2/MTOR/BCL2/MAP2K4/ITGB1/HLX/SORBS2 26 BP GO:0022604 regulation of cell morphogenesis 31/819 484/18670 0.02303 0.1117 0.0857 MYOC/SPARC/TRAK2/CXCL12/POSTN/EPHB2/ZMYM2/NTRK2/PLXND1/ITGB2/CDC42EP1/MYO10/CIB1/TPM1/MYH9/NRP1/DIAPH1/S100A13/HAS2/CHN1/TWF2/EPS8/THY1/PALM/RASA1/ITGB1BP1/PLXNC1/LPAR1/ENPP2/TRPC6/EZR 31 BP GO:0051224 negative regulation of protein transport 15/819 193/18670 0.02316 0.1122 0.08602 IDH2/RANGAP1/TXN/ANGPT1/NR1H3/MDFIC/INHBB/HADH/UBE2J1/ITGB1BP1/GAS6/RSAD2/PTPN11/LMAN1/EZR 15 BP GO:1901654 response to ketone 15/819 193/18670 0.02316 0.1122 0.08602 IGFBP7/THBS1/ADCY8/RAMP2/CLDN4/ADAM15/BCL2L1/NR1H3/WBP2/TGFB2/KLF4/BAD/TNC/CASP9/FOXO3 15 BP GO:0030323 respiratory tube development 14/819 176/18670 0.02319 0.1122 0.08603 MAPK3/PCSK5/SPARC/BMP4/PTK7/LOX/ITGA3/LIPA/EPAS1/PDGFA/LAMA1/WNT11/TNC/CHI3L1 14 BP GO:0060389 pathway-restricted SMAD protein phosphorylation 7/819 65/18670 0.02336 0.1128 0.08651 GREM1/PIN1/EMILIN1/BMP4/TGFBR1/INHBB/TGFB2 7 BP GO:0072577 endothelial cell apoptotic process 7/819 65/18670 0.02336 0.1128 0.08651 THBS1/RAMP2/ANGPT1/SCG2/MAP3K5/GAS6/FOXO3 7 BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 9/819 95/18670 0.02352 0.1133 0.08687 PSMD8/PSMB7/PSMD1/WWTR1/PSMB6/FBXL2/PSMD3/PSMD2/PSMB8 9 BP GO:0051651 maintenance of location in cell 9/819 95/18670 0.02352 0.1133 0.08687 KDELR3/RANGAP1/TXN/HSPA5/GSN/TWF2/ARL2/FLNB/EZR 9 BP GO:1903076 regulation of protein localization to plasma membrane 9/819 95/18670 0.02352 0.1133 0.08687 EPHB2/PIK3R1/BCL2L1/CIB1/ITGA3/STAC/SPTBN1/EZR/ITGB1 9 BP GO:0001505 regulation of neurotransmitter levels 24/819 354/18670 0.02356 0.1134 0.08695 CYP1B1/CLN3/ATP2A2/DDAH2/PPFIA4/SV2A/ITGB2/SLC29A1/ITGB3/NAPA/GPM6B/GART/KLF4/RGS2/JAK2/PRKCB/MTOR/UNC13B/NAAA/PTX3/ASIC1/PER2/ALDH7A1/GRIN2A 24 BP GO:0002088 lens development in camera-type eye 8/819 80/18670 0.02385 0.1147 0.08793 CTNS/CRYAB/KDM5B/BMP4/GJA1/TGFBR1/TDRD7/TMOD1 8 BP GO:0022037 metencephalon development 10/819 111/18670 0.02401 0.1153 0.08845 NAGLU/FOXC1/B4GALT2/HSPA5/CKB/GART/UQCRQ/LPAR1/BCL2/PTPN11 10 BP GO:0006754 ATP biosynthetic process 13/819 160/18670 0.02405 0.1153 0.08846 OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/COX5B/STAT3/SEC13/PGM1/TPI1 13 BP GO:0021915 neural tube development 13/819 160/18670 0.02405 0.1153 0.08846 BMP4/PTK7/FZD2/HIF1A/FZD6/TGFB2/MTHFD1/KDM6A/FZD1/SOX4/SDC4/PHACTR4/TMED2 13 BP GO:0070372 regulation of ERK1 and ERK2 cascade 21/819 300/18670 0.0241 0.1155 0.08857 MAPK3/PIN1/PRKCA/EMILIN1/EPHB2/BMP4/ANGPT1/CIB1/NRP1/CCR1/PDGFA/RAPGEF1/ARRB2/KLF4/ITGB1BP1/GAS6/HTR2B/CHI3L1/PTPN11/PHB/EZR 21 BP GO:1902115 regulation of organelle assembly 15/819 194/18670 0.02413 0.1155 0.08858 STAM/IL1RAP/GAP43/NUPR1/KAT2B/VPS11/GSN/FSCN1/CAV3/CHMP2A/TSG101/CDKL1/SDC4/EZR/PIKFYVE 15 BP GO:0043488 regulation of mRNA stability 14/819 177/18670 0.0242 0.1157 0.0887 PSMD8/PSMB7/PRKCA/EXOSC7/PSMD1/HNRNPA0/SAMD4A/PSMB6/ZFP36/EXOSC2/MTOR/PSMD3/PSMD2/PSMB8 14 BP GO:0006040 amino sugar metabolic process 5/819 38/18670 0.02429 0.1157 0.0887 RENBP/CHST7/ST6GAL1/CHST2/GNPDA1 5 BP GO:0010831 positive regulation of myotube differentiation 5/819 38/18670 0.02429 0.1157 0.0887 MAML1/CAV3/IL4R/MTOR/BCL2 5 BP GO:0016572 histone phosphorylation 5/819 38/18670 0.02429 0.1157 0.0887 MAPK3/PRKCA/JAK2/PRKCB/PKN1 5 BP GO:0048009 insulin-like growth factor receptor signaling pathway 5/819 38/18670 0.02429 0.1157 0.0887 PIK3R1/IGFBP1/GHR/IGFBP6/PLCB1 5 BP GO:1900077 negative regulation of cellular response to insulin stimulus 5/819 38/18670 0.02429 0.1157 0.0887 ENPP1/GRB10/PRKCB/SOCS3/NCK1 5 BP GO:0060041 retina development in camera-type eye 12/819 144/18670 0.02476 0.1177 0.09028 CYP1B1/TGIF2/NTRK2/NRP1/TFAP2A/HIF1A/COL4A1/THY1/ARHGEF15/TGFB2/LAMA1/TCIRG1 12 BP GO:0071322 cellular response to carbohydrate stimulus 12/819 144/18670 0.02476 0.1177 0.09028 NADK/OXCT1/ADCY8/HIF1A/GCLM/GAS6/PRKCB/UNC13B/BAD/MAP2K4/FOXO3/SOX4 12 BP GO:0008585 female gonad development 9/819 96/18670 0.02498 0.1185 0.09091 FOXC1/NUPR1/HSPA5/BCL2L1/INHBB/ARRB2/BCL2/PTX3/FOXO3 9 BP GO:0033108 mitochondrial respiratory chain complex assembly 9/819 96/18670 0.02498 0.1185 0.09091 NDUFB8/NDUFAF3/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 9 BP GO:0046626 regulation of insulin receptor signaling pathway 7/819 66/18670 0.02518 0.119 0.09129 ENPP1/PIK3R1/GRB10/PRKCB/SOCS3/PTPN11/NCK1 7 BP GO:0048207 vesicle targeting, rough ER to cis-Golgi 7/819 66/18670 0.02518 0.119 0.09129 CTSC/GOSR2/NAPA/COL7A1/SEC13/LMAN1/TMED2 7 BP GO:0048208 COPII vesicle coating 7/819 66/18670 0.02518 0.119 0.09129 CTSC/GOSR2/NAPA/COL7A1/SEC13/LMAN1/TMED2 7 BP GO:0051056 regulation of small GTPase mediated signal transduction 23/819 338/18670 0.02528 0.119 0.09129 COL3A1/MYOC/EPHB2/ARHGEF17/MCF2L/ABR/FBP1/NRP1/MET/CD2AP/ITGA3/CHN1/EPS8/PIK3R2/RAPGEF1/ARHGEF15/TGFB2/RASA1/JAK2/LPAR1/CYTH1/RHOBTB2/ITGB1 23 BP GO:0048593 camera-type eye morphogenesis 10/819 112/18670 0.02537 0.119 0.09129 COL8A1/EPHB2/BMP4/TDRD7/TFAP2A/HIF1A/THY1/HMGN1/ALDH1A3/PHACTR4 10 BP GO:0060419 heart growth 10/819 112/18670 0.02537 0.119 0.09129 PIN1/GJA1/TGFBR1/FOXC1/CAV3/TGFB2/RGS2/MTOR/MAP2K4/SORBS2 10 BP GO:0032800 receptor biosynthetic process 4/819 26/18670 0.02547 0.119 0.09129 NR1H3/HIF1A/ITGB3/JAK2 4 BP GO:0045992 negative regulation of embryonic development 4/819 26/18670 0.02547 0.119 0.09129 COL5A2/FZD7/BMP4/SULF1 4 BP GO:0048753 pigment granule organization 4/819 26/18670 0.02547 0.119 0.09129 HPS1/RAB32/LYST/BCL2 4 BP GO:0050926 regulation of positive chemotaxis 4/819 26/18670 0.02547 0.119 0.09129 CXCL12/SCG2/VEGFC/ITGA2 4 BP GO:1903959 regulation of anion transmembrane transport 4/819 26/18670 0.02547 0.119 0.09129 THBS1/RGS2/MTOR/PER2 4 BP GO:1904353 regulation of telomere capping 4/819 26/18670 0.02547 0.119 0.09129 MAPK3/MAP3K4/NEK7/TERF2 4 BP GO:0030811 regulation of nucleotide catabolic process 8/819 81/18670 0.02548 0.119 0.09129 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13 8 BP GO:0033238 regulation of cellular amine metabolic process 8/819 81/18670 0.02548 0.119 0.09129 PSMD8/PSMB7/PSMD1/ITGB2/PSMB6/PSMD3/PSMD2/PSMB8 8 BP GO:0010959 regulation of metal ion transport 26/819 394/18670 0.02561 0.119 0.09129 GSTO1/SLC31A2/CLIC2/STC2/CEMIP/CXCL12/GJA1/HSPA2/SNTA1/MYLK/MYO5A/PDE4B/GNB5/DIAPH1/CCR1/CAV3/THY1/ATP1B1/ARRB2/STAC/GPD1L/KCNMB1/BCL2/CACNA1C/BIN1/TRPC6 26 BP GO:0031529 ruffle organization 6/819 52/18670 0.02563 0.119 0.09129 PLEKHM1/TPM1/EPS8/MTOR/SH3YL1/PIP5K1A 6 BP GO:0072132 mesenchyme morphogenesis 6/819 52/18670 0.02563 0.119 0.09129 TGFBR1/FOXC1/SNAI2/TGFB2/WNT11/ACTA2 6 BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 6/819 52/18670 0.02563 0.119 0.09129 MYOC/POSTN/CIB1/NRP1/HAS2/ITGB1BP1 6 BP GO:1990089 response to nerve growth factor 6/819 52/18670 0.02563 0.119 0.09129 SH3GL2/NTRK2/HSPA5/CIB1/RAPGEF1/FOXO3 6 BP GO:0031647 regulation of protein stability 20/819 284/18670 0.02577 0.119 0.09129 HIP1R/CRYAB/CTSA/PIN1/SEL1L/RAD23A/GRN/PIK3R1/PRKD1/RASSF2/VPS11/GSN/PPIB/ATP1B1/DPM2/BCL2/CCT7/PHB/SOX4/CREBBP 20 BP GO:0006390 mitochondrial transcription 3/819 15/18670 0.02579 0.119 0.09129 MTERF1/FOXO3/POLRMT 3 BP GO:0010759 positive regulation of macrophage chemotaxis 3/819 15/18670 0.02579 0.119 0.09129 MAPK3/RARRES2/THBS1 3 BP GO:0014856 skeletal muscle cell proliferation 3/819 15/18670 0.02579 0.119 0.09129 ANGPT1/STAT3/JAK2 3 BP GO:0030730 sequestering of triglyceride 3/819 15/18670 0.02579 0.119 0.09129 ENPP1/ABHD5/PNPLA2 3 BP GO:0030812 negative regulation of nucleotide catabolic process 3/819 15/18670 0.02579 0.119 0.09129 NUPR1/FBP1/STAT3 3 BP GO:0034349 glial cell apoptotic process 3/819 15/18670 0.02579 0.119 0.09129 PRKCA/GAS6/CASP9 3 BP GO:0050651 dermatan sulfate proteoglycan biosynthetic process 3/819 15/18670 0.02579 0.119 0.09129 BGN/VCAN/NCAN 3 BP GO:0051198 negative regulation of coenzyme metabolic process 3/819 15/18670 0.02579 0.119 0.09129 NUPR1/FBP1/STAT3 3 BP GO:0072160 nephron tubule epithelial cell differentiation 3/819 15/18670 0.02579 0.119 0.09129 MTSS1/WWTR1/CD24 3 BP GO:0090177 establishment of planar polarity involved in neural tube closure 3/819 15/18670 0.02579 0.119 0.09129 PTK7/FZD2/FZD1 3 BP GO:0098840 protein transport along microtubule 3/819 15/18670 0.02579 0.119 0.09129 RAB27B/TERF2/MAP1A 3 BP GO:0099118 microtubule-based protein transport 3/819 15/18670 0.02579 0.119 0.09129 RAB27B/TERF2/MAP1A 3 BP GO:0051090 regulation of DNA-binding transcription factor activity 28/819 432/18670 0.02596 0.1197 0.09183 MAPK3/ENPP1/SFRP4/IL18R1/CYP1B1/TCF7L2/ADCY8/IL1RAP/PRKD1/NUPR1/ITGB2/TRIM25/CIB1/FZD2/LRRFIP1/FZD6/ANXA3/DDR2/STAT3/ARRB2/KLF4/JAK2/GAS6/PRKCB/PPRC1/FZD1/CAT/CDKN2A 28 BP GO:0071347 cellular response to interleukin-1 14/819 179/18670 0.02634 0.1214 0.09308 MAPK3/PSMD8/PSMB7/IL1RAP/PSMD1/HIF1A/PSMB6/HAS2/USP10/PLCB1/CHI3L1/PSMD3/PSMD2/PSMB8 14 BP GO:0045926 negative regulation of growth 18/819 249/18670 0.0265 0.1218 0.09344 ENPP1/CRYAB/STC2/BMP4/GJA1/ADAM15/FBP1/NRP1/HIF1A/NDUFS3/CAV3/TGFB2/RGS2/WNT11/BCL2/PPP2R1A/PHB/CDKN2A 18 BP GO:0006942 regulation of striated muscle contraction 9/819 97/18670 0.02651 0.1218 0.09344 GSTO1/CLIC2/ATP2A2/PDE4B/CAV3/ATP1B1/RGS2/CACNA1C/BIN1 9 BP GO:1902882 regulation of response to oxidative stress 9/819 97/18670 0.02651 0.1218 0.09344 PYCR1/TXN/HIF1A/MET/TRAP1/FBLN5/FZD1/PAWR/FOXO3 9 BP GO:0007257 activation of JUN kinase activity 5/819 39/18670 0.02689 0.1229 0.09423 MDFIC/MAP3K5/MAP4K2/MAP2K4/PKN1 5 BP GO:0009072 aromatic amino acid family metabolic process 5/819 39/18670 0.02689 0.1229 0.09423 PCBD1/QDPR/TYR/FAH/MTHFD1 5 BP GO:0010761 fibroblast migration 5/819 39/18670 0.02689 0.1229 0.09423 THBS1/DDR2/ITGB1BP1/PIP5K1A/SDC4 5 BP GO:0030501 positive regulation of bone mineralization 5/819 39/18670 0.02689 0.1229 0.09423 ISG15/BMP4/FBN2/TFAP2A/GPM6B 5 BP GO:0050856 regulation of T cell receptor signaling pathway 5/819 39/18670 0.02689 0.1229 0.09423 KCNN4/THY1/RAB29/PAWR/EZR 5 BP GO:0072595 maintenance of protein localization in organelle 5/819 39/18670 0.02689 0.1229 0.09423 KDELR3/RANGAP1/TXN/HSPA5/ARL2 5 BP GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 5/819 39/18670 0.02689 0.1229 0.09423 NACC2/CXCL12/BCL2L1/SNAI2/BCL2 5 BP GO:0040013 negative regulation of locomotion 26/819 396/18670 0.02705 0.1235 0.09471 COL3A1/GREM1/IDH2/THBS1/CYP1B1/PIN1/CXCL12/EMILIN1/ADARB1/MCC/ADAM15/TRIM25/DPYSL3/ABR/TPM1/NRP1/PTPRK/THY1/STAT3/KLF4/ITGB1BP1/SULF1/WNT11/BCL2/PLCB1/FOXO3 26 BP GO:0019748 secondary metabolic process 7/819 67/18670 0.02709 0.1236 0.09477 CTNS/CYP1B1/FMO1/MYO5A/TYR/BCL2/FMO2 7 BP GO:0009156 ribonucleoside monophosphate biosynthetic process 15/819 197/18670 0.0272 0.1238 0.09494 AK1/OGDH/NUPR1/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/GART/COX5B/STAT3/SEC13/PGM1/TPI1 15 BP GO:0009749 response to glucose 15/819 197/18670 0.0272 0.1238 0.09494 NADK/THBS1/OXCT1/TCF7L2/ADCY8/GJA1/LDHA/HIF1A/GCLM/GAS6/UNC13B/BAD/ENSA/FOXO3/SOX4 15 BP GO:1904950 negative regulation of establishment of protein localization 15/819 197/18670 0.0272 0.1238 0.09494 IDH2/RANGAP1/TXN/ANGPT1/NR1H3/MDFIC/INHBB/HADH/UBE2J1/ITGB1BP1/GAS6/RSAD2/PTPN11/LMAN1/EZR 15 BP GO:0051170 import into nucleus 13/819 163/18670 0.02748 0.1248 0.0957 ARNTL/BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/NUP93/NUP153/PIK3R2/STAT3/PTTG1IP/MBTPS1/KPNA3 13 BP GO:1902600 proton transmembrane transport 13/819 163/18670 0.02748 0.1248 0.0957 ATP6V0E2/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/NDUFS7/COX5B/UCP2/COX7A2/TCIRG1/ATP6V1D 13 BP GO:0044262 cellular carbohydrate metabolic process 20/819 286/18670 0.02749 0.1248 0.0957 ENPP1/SYNJ2/IDH2/NDST1/SORD/NUPR1/KAT2B/FBP1/HAS2/STAT3/PDK1/EXT1/IL6ST/MTOR/BAD/INPP5E/PDK2/PGM1/PER2/TPI1 20 BP GO:0007632 visual behavior 6/819 53/18670 0.02786 0.1263 0.09684 CTNS/B4GALT2/HIF1A/MTOR/GRIN2A/ITGB1 6 BP GO:0032964 collagen biosynthetic process 6/819 53/18670 0.02786 0.1263 0.09684 EMILIN1/COL1A1/SERPINH1/BMP4/ARRB2/ITGA2 6 BP GO:0002429 immune response-activating cell surface receptor signaling pathway 30/819 473/18670 0.02809 0.1271 0.09748 MAPK3/FPR1/PSMD8/PSMB7/MICB/PIK3R1/PSMD1/MYO10/PDE4B/PSMB6/ARPC1B/KCNN4/PIK3R2/HLA-DRB4/PIK3CB/RAPGEF1/THY1/PRKCB/IGLL1/HLA-DQB1/RAB29/BCL2/PSMD3/PAWR/PSMD2/EZR/PSMB8/CREBBP/NCK1/HLA-DPB1 30 BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 9/819 98/18670 0.0281 0.1271 0.09748 SH3GL2/CAPZA2/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/HLA-DPB1 9 BP GO:0030218 erythrocyte differentiation 10/819 114/18670 0.02825 0.1277 0.09793 ISG15/BMP4/ADAR/HIF1A/EPAS1/PRMT1/STAT3/JAK2/ZFP36/FOXO3 10 BP GO:0002262 myeloid cell homeostasis 12/819 147/18670 0.02849 0.1287 0.0987 ISG15/BMP4/ADAR/PDE4B/HIF1A/EPAS1/PRMT1/PIK3CB/STAT3/JAK2/ZFP36/FOXO3 12 BP GO:0002825 regulation of T-helper 1 type immune response 4/819 27/18670 0.02889 0.13 0.09967 IL18R1/SOCS5/IL4R/HLX 4 BP GO:0003148 outflow tract septum morphogenesis 4/819 27/18670 0.02889 0.13 0.09967 BMP4/NRP1/TGFB2/NRP2 4 BP GO:0035883 enteroendocrine cell differentiation 4/819 27/18670 0.02889 0.13 0.09967 ARNTL/RFX3/BMP4/BAD 4 BP GO:0036336 dendritic cell migration 4/819 27/18670 0.02889 0.13 0.09967 IL12A/CCR1/EPS8/GAS6 4 BP GO:0098810 neurotransmitter reuptake 4/819 27/18670 0.02889 0.13 0.09967 SLC29A1/ITGB3/GPM6B/PER2 4 BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 8/819 83/18670 0.02898 0.1303 0.09989 CRLF1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3/PPP2R1A 8 BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 7/819 68/18670 0.0291 0.1307 0.1002 RAMP2/FOXC1/VEGFC/PRKD1/NRP1/ITGB1BP1/NRP2 7 BP GO:0007548 sex differentiation 19/819 270/18670 0.02941 0.1315 0.1009 ASB1/GJA1/TGFBR1/FOXC1/NUPR1/HSPA5/ADAM15/BCL2L1/INHBB/FKBP4/TGFB2/ARRB2/ROR2/BCL2/PTX3/PTPN11/FOXO3/EIF2S2/TMF1 19 BP GO:0016052 carbohydrate catabolic process 15/819 199/18670 0.02941 0.1315 0.1009 SORD/OGDH/NUPR1/GM2A/LDHA/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/BAD/PGM1/TPI1 15 BP GO:0034341 response to interferon-gamma 15/819 199/18670 0.02941 0.1315 0.1009 OAS1/OAS2/NR1H2/TRIM25/NR1H3/GSN/HLA-DRB4/FLNB/JAK2/OASL/SOCS3/HLA-DQB1/IRF7/VAMP3/HLA-DPB1 15 BP GO:0050866 negative regulation of cell activation 15/819 199/18670 0.02941 0.1315 0.1009 THOC1/EMILIN1/GRN/BMP4/NR1H3/ABR/TNFRSF14/IL13RA2/PDGFA/SOCS5/IL4R/PAWR/SDC4/PKN1/HLX 15 BP GO:0061013 regulation of mRNA catabolic process 15/819 199/18670 0.02941 0.1315 0.1009 PSMD8/PSMB7/PRKCA/EXOSC7/PSMD1/HNRNPA0/SAMD4A/TNRC6B/PSMB6/ZFP36/EXOSC2/MTOR/PSMD3/PSMD2/PSMB8 15 BP GO:0032008 positive regulation of TOR signaling 5/819 40/18670 0.02966 0.1323 0.1015 RRAGD/LAMTOR5/CLEC16A/GAS6/SEC13 5 BP GO:0071526 semaphorin-plexin signaling pathway 5/819 40/18670 0.02966 0.1323 0.1015 PLXND1/NRP1/MET/PLXNC1/NRP2 5 BP GO:2000008 regulation of protein localization to cell surface 5/819 40/18670 0.02966 0.1323 0.1015 TM9SF4/GPM6B/CAV3/GPD1L/MAP1A 5 BP GO:0043648 dicarboxylic acid metabolic process 9/819 99/18670 0.02975 0.1325 0.1016 IDH2/MTHFD2/SDHA/OGDH/FOLR2/GCLM/SDHB/MTHFD1/MDH2 9 BP GO:1904375 regulation of protein localization to cell periphery 10/819 115/18670 0.02977 0.1325 0.1016 EPHB2/PIK3R1/BCL2L1/CIB1/GPC4/ITGA3/STAC/SPTBN1/EZR/ITGB1 10 BP GO:0009166 nucleotide catabolic process 14/819 182/18670 0.02979 0.1325 0.1016 OGDH/NUPR1/MBD4/LDHA/FBP1/PDE4B/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/PGM1/TPI1 14 BP GO:0035107 appendage morphogenesis 12/819 148/18670 0.02982 0.1325 0.1016 PCSK5/BMP4/GJA1/FBN2/TFAP2A/FZD6/TGFB2/IQCE/ROR2/CACNA1C/SOX4/CREBBP 12 BP GO:0035108 limb morphogenesis 12/819 148/18670 0.02982 0.1325 0.1016 PCSK5/BMP4/GJA1/FBN2/TFAP2A/FZD6/TGFB2/IQCE/ROR2/CACNA1C/SOX4/CREBBP 12 BP GO:0042176 regulation of protein catabolic process 25/819 381/18670 0.02991 0.1328 0.1018 ARNTL/CTSC/USP5/CTSA/PIN1/RAD23A/GJA1/NUPR1/PSMD1/RNF144A/VPS11/CLEC16A/UBE2J1/CAV3/PTTG1IP/SOCS5/MAP1A/PHB/PSMD3/RYBP/RCHY1/PSMD2/EZR/GRIN2A/TMF1 25 BP GO:0050954 sensory perception of mechanical stimulus 13/819 165/18670 0.02996 0.1329 0.1019 LRIG1/CEMIP/COL11A1/CXCL12/COL1A1/SNAI2/TFAP2A/DIAPH1/SERPINB6/ITGA2/ALDH7A1/CLIC5/CRYM 13 BP GO:0045747 positive regulation of Notch signaling pathway 6/819 54/18670 0.03023 0.1338 0.1026 MAML1/KAT2B/STAT3/TGFB2/ITGB1BP1/CREBBP 6 BP GO:0046164 alcohol catabolic process 6/819 54/18670 0.03023 0.1338 0.1026 SYNJ2/SORD/CYP27A1/INPP5E/ALDH2/TPI1 6 BP GO:0097193 intrinsic apoptotic signaling pathway 20/819 289/18670 0.03024 0.1338 0.1026 NACC2/CYP1B1/CXCL12/PIK3R1/NUPR1/BCL2L1/SNAI2/MAP3K5/HIF1A/NDUFS3/TRAP1/CD24/PDK1/PTTG1IP/JAK2/BAD/BCL2/PDK2/CASP9/NCK1 20 BP GO:1901617 organic hydroxy compound biosynthetic process 19/819 271/18670 0.03038 0.1343 0.103 VDR/CTNS/TM7SF2/PCBD1/ABCG1/LBR/QDPR/SNAI2/CYP3A4/MYO5A/CYP27A1/TYR/PLTP/TGFB2/ASAH1/PLCB1/MBTPS1/PER2/NFYB 19 BP GO:0002070 epithelial cell maturation 3/819 16/18670 0.03073 0.1345 0.1032 RFX3/GJA1/HIF1A 3 BP GO:0002739 regulation of cytokine secretion involved in immune response 3/819 16/18670 0.03073 0.1345 0.1032 MAPK3/ANGPT1/TNFRSF14 3 BP GO:0010885 regulation of cholesterol storage 3/819 16/18670 0.03073 0.1345 0.1032 ABCG1/NR1H2/NR1H3 3 BP GO:0030033 microvillus assembly 3/819 16/18670 0.03073 0.1345 0.1032 PODXL/FSCN1/EZR 3 BP GO:0031958 corticosteroid receptor signaling pathway 3/819 16/18670 0.03073 0.1345 0.1032 ARNTL/JAK2/PHB 3 BP GO:0035372 protein localization to microtubule 3/819 16/18670 0.03073 0.1345 0.1032 DIAPH1/MAPRE3/MAP1A 3 BP GO:0044827 modulation by host of viral genome replication 3/819 16/18670 0.03073 0.1345 0.1032 PPIB/IFI27/FBXL2 3 BP GO:0045623 negative regulation of T-helper cell differentiation 3/819 16/18670 0.03073 0.1345 0.1032 SOCS5/IL4R/HLX 3 BP GO:0050655 dermatan sulfate proteoglycan metabolic process 3/819 16/18670 0.03073 0.1345 0.1032 BGN/VCAN/NCAN 3 BP GO:1902992 negative regulation of amyloid precursor protein catabolic process 3/819 16/18670 0.03073 0.1345 0.1032 PIN1/SPON1/BIN1 3 BP GO:2000369 regulation of clathrin-dependent endocytosis 3/819 16/18670 0.03073 0.1345 0.1032 HIP1R/SH3GL2/PIK3CB 3 BP GO:2001170 negative regulation of ATP biosynthetic process 3/819 16/18670 0.03073 0.1345 0.1032 NUPR1/FBP1/STAT3 3 BP GO:0045995 regulation of embryonic development 11/819 132/18670 0.03075 0.1345 0.1032 COL5A2/FZD7/BMP4/TGIF2/PTK7/FZD2/KLF4/SULF1/LAMA1/PLCB1/FZD1 11 BP GO:0010507 negative regulation of autophagy 8/819 84/18670 0.03085 0.1349 0.1034 CTSA/NUPR1/MET/CLEC16A/STAT3/MTOR/BCL2/HTR2B 8 BP GO:0043487 regulation of RNA stability 14/819 183/18670 0.03102 0.1355 0.1039 PSMD8/PSMB7/PRKCA/EXOSC7/PSMD1/HNRNPA0/SAMD4A/PSMB6/ZFP36/EXOSC2/MTOR/PSMD3/PSMD2/PSMB8 14 BP GO:0009267 cellular response to starvation 12/819 149/18670 0.0312 0.1359 0.1043 MAPK3/RRAGD/PRKD1/HSPA5/PIK3C3/INHBB/MAP3K5/CLEC16A/GAS6/MTOR/BCL2/MAP1LC3B 12 BP GO:0042063 gliogenesis 20/819 290/18670 0.0312 0.1359 0.1043 MAPK3/IDH2/MYOC/GRN/GAP43/LAMB1/NTRK2/PLP1/GSN/TSPAN2/STAT3/TGFB2/IL6ST/LPAR1/MTOR/ROR2/BIN1/PTPN11/SOX4/NAB1 20 BP GO:0051650 establishment of vesicle localization 20/819 290/18670 0.0312 0.1359 0.1043 CTSC/TRAK2/CLN3/ATP2A2/SV2A/RAB27B/KIAA1107/GOSR2/MYO5A/NAPA/SPG11/DYNC1I1/COL7A1/MAP4K2/ARFGAP2/SEC13/PRKCB/UNC13B/LMAN1/TMED2 20 BP GO:1900180 regulation of protein localization to nucleus 10/819 116/18670 0.03136 0.1365 0.1047 PIN1/BMP4/ANGPT1/PIK3R1/MDFIC/CD2AP/NOLC1/PIK3R2/CCT7/BYSL 10 BP GO:0042098 T cell proliferation 14/819 184/18670 0.03227 0.1403 0.1076 CD55/CD151/BMP4/GJA1/CD70/IL12A/TNFRSF14/CD24/IL6ST/PAWR/SDC4/CTPS1/NCK1/HLA-DPB1 14 BP GO:0043409 negative regulation of MAPK cascade 14/819 184/18670 0.03227 0.1403 0.1076 PIN1/EMILIN1/EPHB2/BMP4/PIK3R2/RAPGEF1/CAV3/KLF4/ITGB1BP1/RGS2/DUSP7/PPP2R1A/PHB/EZR 14 BP GO:0007050 cell cycle arrest 17/819 237/18670 0.03244 0.1404 0.1076 THBS1/TCF7L2/RRAGD/TGFBR1/KAT2B/IL12A/LAMTOR5/FAP/CGREF1/PRMT1/TGFB2/GAS6/MTOR/TSG101/BIN1/SOX4/CDKN2A 17 BP GO:0032872 regulation of stress-activated MAPK cascade 17/819 237/18670 0.03244 0.1404 0.1076 MAPK3/MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/RAPGEF1/CAV3/TGFB2/ROR2/MAP2K4/PLCB1/EZR/PKN1 17 BP GO:0003180 aortic valve morphogenesis 4/819 28/18670 0.03257 0.1404 0.1076 EMILIN1/BMP4/ELN/SNAI2 4 BP GO:0006760 folic acid-containing compound metabolic process 4/819 28/18670 0.03257 0.1404 0.1076 MTHFD2/FOLR2/GART/MTHFD1 4 BP GO:0070076 histone lysine demethylation 4/819 28/18670 0.03257 0.1404 0.1076 KDM5B/PHF2/KDM6A/HSF4 4 BP GO:1902003 regulation of amyloid-beta formation 4/819 28/18670 0.03257 0.1404 0.1076 PIN1/ABCG1/SPON1/BIN1 4 BP GO:1902745 positive regulation of lamellipodium organization 4/819 28/18670 0.03257 0.1404 0.1076 TWF2/FSCN1/MTOR/ENPP2 4 BP GO:1903792 negative regulation of anion transport 4/819 28/18670 0.03257 0.1404 0.1076 SFRP4/THBS1/RGS2/MTOR 4 BP GO:0006458 'de novo' protein folding 5/819 41/18670 0.0326 0.1404 0.1076 HSPA5/HSPA2/DNAJC2/DNAJB5/BAG1 5 BP GO:0007520 myoblast fusion 5/819 41/18670 0.0326 0.1404 0.1076 ADAM12/MYH9/CAV3/IL4R/DYRK1B 5 BP GO:0050434 positive regulation of viral transcription 5/819 41/18670 0.0326 0.1404 0.1076 POLR2L/POLR2E/MDFIC/SUPT4H1/CHD1 5 BP GO:1903053 regulation of extracellular matrix organization 5/819 41/18670 0.0326 0.1404 0.1076 EMILIN1/FAP/HAS2/FSCN1/DDR2 5 BP GO:0002090 regulation of receptor internalization 6/819 55/18670 0.03272 0.1406 0.1079 SFRP4/GREM1/SH3GL2/ANGPT1/ITGB3/ARRB2 6 BP GO:0042306 regulation of protein import into nucleus 6/819 55/18670 0.03272 0.1406 0.1079 BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/PIK3R2 6 BP GO:0034308 primary alcohol metabolic process 8/819 85/18670 0.0328 0.1408 0.108 CYP1B1/ADH1C/CYP3A4/ADH1A/ADH1B/NAAA/ALDH2/ALDH1A3 8 BP GO:0045682 regulation of epidermis development 8/819 85/18670 0.0328 0.1408 0.108 SFRP4/VDR/BMP4/FOXC1/TGFB2/ZFP36/SULT2B1/NAB1 8 BP GO:0009746 response to hexose 15/819 202/18670 0.03296 0.1411 0.1082 NADK/THBS1/OXCT1/TCF7L2/ADCY8/GJA1/LDHA/HIF1A/GCLM/GAS6/UNC13B/BAD/ENSA/FOXO3/SOX4 15 BP GO:0050870 positive regulation of T cell activation 15/819 202/18670 0.03296 0.1411 0.1082 CD55/PIK3R1/CD70/IL12A/TNFRSF14/CD24/THY1/SOCS5/IL6ST/IL4R/BAD/PTPN11/NCK1/HLX/HLA-DPB1 15 BP GO:0060147 regulation of posttranscriptional gene silencing 10/819 117/18670 0.033 0.1411 0.1082 POLR2L/POLR2E/BMP4/ADAR/NUP205/NUP93/NUP153/STAT3/ZFP36/SEC13 10 BP GO:0060966 regulation of gene silencing by RNA 10/819 117/18670 0.033 0.1411 0.1082 POLR2L/POLR2E/BMP4/ADAR/NUP205/NUP93/NUP153/STAT3/ZFP36/SEC13 10 BP GO:1900371 regulation of purine nucleotide biosynthetic process 10/819 117/18670 0.033 0.1411 0.1082 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/PDK2 10 BP GO:0002027 regulation of heart rate 9/819 101/18670 0.03327 0.1417 0.1086 ATP2A2/KCND3/TPM1/SNTA1/EPAS1/CAV3/GPD1L/CACNA1C/BIN1 9 BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 9/819 101/18670 0.03327 0.1417 0.1086 SH3GL2/CAPZA2/DYNC1I1/HLA-DRB4/SEC13/HLA-DQB1/AP2B1/KIF2C/HLA-DPB1 9 BP GO:0016073 snRNA metabolic process 9/819 101/18670 0.03327 0.1417 0.1086 POLR2L/POLR2E/EXOSC7/USPL1/SNAPC4/ELL2/EXOSC2/NHP2/SNAPC5 9 BP GO:0046545 development of primary female sexual characteristics 9/819 101/18670 0.03327 0.1417 0.1086 FOXC1/NUPR1/HSPA5/BCL2L1/INHBB/ARRB2/BCL2/PTX3/FOXO3 9 BP GO:0048661 positive regulation of smooth muscle cell proliferation 9/819 101/18670 0.03327 0.1417 0.1086 THBS1/BMP4/TGM2/ABCC4/MAP3K5/NOTCH3/JAK2/MTOR/ITGA2 9 BP GO:0070988 demethylation 7/819 70/18670 0.03341 0.1422 0.109 KDM5B/APOBEC3B/PHF2/CYP3A4/APOBEC3C/KDM6A/HSF4 7 BP GO:0046683 response to organophosphorus 11/819 134/18670 0.0338 0.1437 0.1102 SPARC/COL1A1/HSPA5/RFC3/LDHA/TYR/RAPGEF1/CNGA3/LPAR1/P2RY2/EZR 11 BP GO:0030808 regulation of nucleotide biosynthetic process 10/819 118/18670 0.0347 0.1474 0.113 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/PDK2 10 BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 17/819 239/18670 0.03473 0.1475 0.1131 MAPK3/MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/RAPGEF1/CAV3/TGFB2/ROR2/MAP2K4/PLCB1/EZR/PKN1 17 BP GO:0007260 tyrosine phosphorylation of STAT protein 8/819 86/18670 0.03483 0.1475 0.1131 CRLF1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3/PPP2R1A 8 BP GO:0034637 cellular carbohydrate biosynthetic process 8/819 86/18670 0.03483 0.1475 0.1131 ENPP1/NDST1/FBP1/HAS2/EXT1/MTOR/PGM1/PER2 8 BP GO:0090559 regulation of membrane permeability 8/819 86/18670 0.03483 0.1475 0.1131 HIP1R/BCL2L1/NMT1/STAT3/MTOR/BAD/BCL2/HEBP2 8 BP GO:0002367 cytokine production involved in immune response 9/819 102/18670 0.03513 0.1483 0.1137 MAPK3/CD55/IL18R1/ANGPT1/IL12A/TNFRSF14/TGFB2/GAS6/RSAD2 9 BP GO:0006900 vesicle budding from membrane 9/819 102/18670 0.03513 0.1483 0.1137 CTSC/GOSR2/NAPA/COL7A1/ARFGAP2/SEC13/SEC23B/LMAN1/TMED2 9 BP GO:0021549 cerebellum development 9/819 102/18670 0.03513 0.1483 0.1137 NAGLU/FOXC1/B4GALT2/HSPA5/CKB/GART/UQCRQ/LPAR1/PTPN11 9 BP GO:0098869 cellular oxidant detoxification 9/819 102/18670 0.03513 0.1483 0.1137 GSTO1/CLIC2/PXDN/TXN/SOD3/GPX4/GPX3/FBLN5/CAT 9 BP GO:0006749 glutathione metabolic process 6/819 56/18670 0.03534 0.1485 0.1139 CTNS/GGT5/HAGH/GGCT/GCLM/GPX4 6 BP GO:0010332 response to gamma radiation 6/819 56/18670 0.03534 0.1485 0.1139 CRYAB/HSPA5/BCL2L1/POLE3/XRCC6/BCL2 6 BP GO:0046148 pigment biosynthetic process 6/819 56/18670 0.03534 0.1485 0.1139 CTNS/MYO5A/TYR/UROS/GART/MTHFD1 6 BP GO:0060688 regulation of morphogenesis of a branching structure 6/819 56/18670 0.03534 0.1485 0.1139 MAGED1/BMP4/SNAI2/PDGFA/CAV3/SULF1 6 BP GO:0090183 regulation of kidney development 6/819 56/18670 0.03534 0.1485 0.1139 MAGED1/BMP4/WWTR1/PDGFA/CD24/PRKX 6 BP GO:1903202 negative regulation of oxidative stress-induced cell death 6/819 56/18670 0.03534 0.1485 0.1139 PYCR1/TXN/HIF1A/MET/TRAP1/FZD1 6 BP GO:0051100 negative regulation of binding 13/819 169/18670 0.03539 0.1486 0.114 MAPK3/IFIT2/PIN1/HSPA5/HABP4/ADAM15/IFIT1/MET/ARRB2/ITGB1BP1/JAK2/PER2/CAMK1 13 BP GO:0001678 cellular glucose homeostasis 12/819 152/18670 0.03559 0.1492 0.1144 NADK/OXCT1/ADCY8/PIK3R1/HIF1A/PIK3R2/GCLM/GAS6/UNC13B/BAD/FOXO3/SOX4 12 BP GO:0010559 regulation of glycoprotein biosynthetic process 5/819 42/18670 0.03572 0.1492 0.1144 TCF7L2/ITM2B/BCL2/PLCB1/PAWR 5 BP GO:0017145 stem cell division 5/819 42/18670 0.03572 0.1492 0.1144 FZD7/SOX5/WWTR1/TEAD3/TGFB2 5 BP GO:0099622 cardiac muscle cell membrane repolarization 5/819 42/18670 0.03572 0.1492 0.1144 GJA1/KCND3/SNTA1/CAV3/ATP1B1 5 BP GO:0033692 cellular polysaccharide biosynthetic process 7/819 71/18670 0.03572 0.1492 0.1144 ENPP1/NDST1/HAS2/EXT1/MTOR/PGM1/PER2 7 BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 7/819 71/18670 0.03572 0.1492 0.1144 CRLF1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3 7 BP GO:0044786 cell cycle DNA replication 7/819 71/18670 0.03572 0.1492 0.1144 PRIM2/RFC3/POLE3/RPA3/TERF2/PRIM1/POLD2 7 BP GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 3/819 17/18670 0.03612 0.1501 0.1151 TGFBR1/SNAI2/TGFB2 3 BP GO:0006474 N-terminal protein amino acid acetylation 3/819 17/18670 0.03612 0.1501 0.1151 KAT2B/SOX4/CREBBP 3 BP GO:0006825 copper ion transport 3/819 17/18670 0.03612 0.1501 0.1151 SLC31A2/ATOX1/FKBP4 3 BP GO:0010715 regulation of extracellular matrix disassembly 3/819 17/18670 0.03612 0.1501 0.1151 FAP/FSCN1/DDR2 3 BP GO:0042249 establishment of planar polarity of embryonic epithelium 3/819 17/18670 0.03612 0.1501 0.1151 PTK7/FZD2/FZD1 3 BP GO:1904355 positive regulation of telomere capping 3/819 17/18670 0.03612 0.1501 0.1151 MAPK3/MAP3K4/NEK7 3 BP GO:2000641 regulation of early endosome to late endosome transport 3/819 17/18670 0.03612 0.1501 0.1151 MAPK3/VPS11/EZR 3 BP GO:0010575 positive regulation of vascular endothelial growth factor production 4/819 29/18670 0.03652 0.1507 0.1156 CYP1B1/HIF1A/SULF1/IL6ST 4 BP GO:0010644 cell communication by electrical coupling 4/819 29/18670 0.03652 0.1507 0.1156 GJA1/GJC1/ATP1B1/CACNA1C 4 BP GO:0010954 positive regulation of protein processing 4/819 29/18670 0.03652 0.1507 0.1156 MYH9/GSN/SPON1/PHB 4 BP GO:0016577 histone demethylation 4/819 29/18670 0.03652 0.1507 0.1156 KDM5B/PHF2/KDM6A/HSF4 4 BP GO:0031116 positive regulation of microtubule polymerization 4/819 29/18670 0.03652 0.1507 0.1156 MET/ARL2/CAV3/CLIP1 4 BP GO:0031365 N-terminal protein amino acid modification 4/819 29/18670 0.03652 0.1507 0.1156 KAT2B/NMT1/SOX4/CREBBP 4 BP GO:0033032 regulation of myeloid cell apoptotic process 4/819 29/18670 0.03652 0.1507 0.1156 PIK3CB/IRF7/BCL2/CDKN2A 4 BP GO:0044788 modulation by host of viral process 4/819 29/18670 0.03652 0.1507 0.1156 PPIB/IFI27/FBXL2/PTX3 4 BP GO:0060536 cartilage morphogenesis 4/819 29/18670 0.03652 0.1507 0.1156 COL14A1/SNAI2/COL6A3/COL7A1 4 BP GO:0045844 positive regulation of striated muscle tissue development 8/819 87/18670 0.03695 0.1522 0.1167 GREM1/ARNTL/PIN1/BMP4/GJA1/ARRB2/MTOR/BCL2 8 BP GO:0048636 positive regulation of muscle organ development 8/819 87/18670 0.03695 0.1522 0.1167 GREM1/ARNTL/PIN1/BMP4/GJA1/ARRB2/MTOR/BCL2 8 BP GO:0034766 negative regulation of ion transmembrane transport 9/819 103/18670 0.03706 0.1524 0.1169 GSTO1/CLIC2/THBS1/EPHB2/GNB5/CAV3/RGS2/MTOR/BIN1 9 BP GO:0048259 regulation of receptor-mediated endocytosis 9/819 103/18670 0.03706 0.1524 0.1169 SFRP4/GREM1/HIP1R/SH3GL2/ANGPT1/CD2AP/ITGB3/PIK3CB/ARRB2 9 BP GO:0045444 fat cell differentiation 16/819 223/18670 0.03709 0.1525 0.1169 ENPP1/ADIRF/ARNTL/RARRES2/TCF7L2/WWTR1/INHBB/SNAI2/KLF4/RGS2/ITGA6/ZFP36/MTOR/PLCB1/PER2/PSMB8 16 BP GO:0090316 positive regulation of intracellular protein transport 12/819 153/18670 0.03715 0.1526 0.117 CEMIP/TCF7L2/PIK3R1/ITGB2/CIB1/TM9SF4/VPS11/PIK3R2/ITGB1BP1/GAS6/RAB29/CAMK1 12 BP GO:0001755 neural crest cell migration 6/819 57/18670 0.03809 0.1561 0.1197 BMP4/NRP1/HIF1A/HTR2B/NRP2/PHACTR4 6 BP GO:0075733 intracellular transport of virus 6/819 57/18670 0.03809 0.1561 0.1197 NUP205/NUP93/NUP153/SEC13/TSG101/KPNA3 6 BP GO:1900408 negative regulation of cellular response to oxidative stress 6/819 57/18670 0.03809 0.1561 0.1197 PYCR1/TXN/HIF1A/MET/TRAP1/FZD1 6 BP GO:0006109 regulation of carbohydrate metabolic process 15/819 206/18670 0.03818 0.1563 0.1199 ENPP1/NUPR1/KAT2B/FBP1/HIF1A/HAS2/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/MTOR/BAD/PDK2 15 BP GO:0006721 terpenoid metabolic process 10/819 120/18670 0.03828 0.1566 0.1201 RARRES2/CYP1B1/ADH1C/HSPG2/CYP3A4/ADH1A/ADH1B/GPC4/ALDH1A3/SDC4 10 BP GO:0043901 negative regulation of multi-organism process 13/819 171/18670 0.03835 0.1568 0.1203 OAS1/MICB/ISG15/TRIM25/IFIT1/GSN/BANF1/OASL/RSAD2/ZFP36/APOBEC3C/PTX3/MX1 13 BP GO:1903522 regulation of blood circulation 20/819 297/18670 0.03857 0.1576 0.1209 GSTO1/CLIC2/ATP2A2/GJA1/GJC1/KCND3/TPM1/SNTA1/PDE4B/ITPR3/EPAS1/CAV3/ATP1B1/TGFB2/RGS2/JAK2/GPD1L/CACNA1C/BIN1/PER2 20 BP GO:0006775 fat-soluble vitamin metabolic process 5/819 43/18670 0.03901 0.1583 0.1214 VDR/SNAI2/CYP3A4/CYP27A1/PLTP 5 BP GO:0006904 vesicle docking involved in exocytosis 5/819 43/18670 0.03901 0.1583 0.1214 VPS11/RAB8A/UNC13B/VPS45/VAMP3 5 BP GO:0034198 cellular response to amino acid starvation 5/819 43/18670 0.03901 0.1583 0.1214 MAPK3/RRAGD/PRKD1/MAP3K5/MTOR 5 BP GO:0038202 TORC1 signaling 5/819 43/18670 0.03901 0.1583 0.1214 RRAGD/LAMTOR5/CLEC16A/SEC13/MTOR 5 BP GO:0086004 regulation of cardiac muscle cell contraction 5/819 43/18670 0.03901 0.1583 0.1214 ATP2A2/PDE4B/CAV3/CACNA1C/BIN1 5 BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 9/819 104/18670 0.03906 0.1583 0.1214 NACC2/CXCL12/PIK3R1/NUPR1/BCL2L1/SNAI2/BAD/BCL2/CASP9 9 BP GO:0071887 leukocyte apoptotic process 9/819 104/18670 0.03906 0.1583 0.1214 CXCL12/BMP4/HIF1A/PIK3CB/GAS6/IRF7/CASP9/CDKN2A/PKN1 9 BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9/819 104/18670 0.03906 0.1583 0.1214 THBS1/BMP4/TGFBR1/INHBB/NUP93/TGFB2/SULF1/ZNF423/CREBBP 9 BP GO:0006767 water-soluble vitamin metabolic process 8/819 88/18670 0.03915 0.1583 0.1214 ENPP1/GSTO1/PCCB/MTHFD2/FOLR2/MTHFD1/FLAD1/BTD 8 BP GO:0009791 post-embryonic development 8/819 88/18670 0.03915 0.1583 0.1214 KDM5B/BMP4/TGFBR1/EFEMP1/KLF4/HMGN1/MTOR/BCL2 8 BP GO:0043470 regulation of carbohydrate catabolic process 8/819 88/18670 0.03915 0.1583 0.1214 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13 8 BP GO:0043506 regulation of JUN kinase activity 8/819 88/18670 0.03915 0.1583 0.1214 MAP3K4/SASH1/MDFIC/MAP3K5/MAP4K2/ROR2/MAP2K4/PKN1 8 BP GO:0045921 positive regulation of exocytosis 8/819 88/18670 0.03915 0.1583 0.1214 STAM/ITGB2/RAB27B/IL4R/CHMP2A/TSG101/UNC13B/SDC4 8 BP GO:1901863 positive regulation of muscle tissue development 8/819 88/18670 0.03915 0.1583 0.1214 GREM1/ARNTL/PIN1/BMP4/GJA1/ARRB2/MTOR/BCL2 8 BP GO:0002064 epithelial cell development 15/819 207/18670 0.03957 0.1596 0.1224 ARNTL/RFX3/BMP4/GJA1/PALLD/IQGAP1/TMOD1/HIF1A/MET/PODXL/FLNB/RAPGEF1/BAD/ACTA2/EZR 15 BP GO:0006643 membrane lipid metabolic process 15/819 207/18670 0.03957 0.1596 0.1224 PLA2G15/ST3GAL5/CTSA/CYP1B1/CLN3/ESYT1/ELOVL2/PRKD1/GM2A/PIGH/SERINC5/ASAH1/DPM2/TECR/PPP2R1A 15 BP GO:0070555 response to interleukin-1 15/819 207/18670 0.03957 0.1596 0.1224 MAPK3/PSMD8/PSMB7/PRKCA/IL1RAP/PSMD1/HIF1A/PSMB6/HAS2/USP10/PLCB1/CHI3L1/PSMD3/PSMD2/PSMB8 15 BP GO:0021543 pallium development 13/819 172/18670 0.0399 0.1606 0.1232 COL3A1/LAMB1/NTRK2/TACC2/NRP1/HIF1A/ANXA3/GNG12/GART/UQCRQ/BAD/PLCB1/NRP2 13 BP GO:0030324 lung development 13/819 172/18670 0.0399 0.1606 0.1232 MAPK3/SPARC/BMP4/PTK7/LOX/ITGA3/LIPA/EPAS1/PDGFA/LAMA1/WNT11/TNC/CHI3L1 13 BP GO:0032874 positive regulation of stress-activated MAPK cascade 13/819 172/18670 0.0399 0.1606 0.1232 MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/TGFB2/ROR2/MAP2K4/PLCB1/PKN1 13 BP GO:0070371 ERK1 and ERK2 cascade 21/819 317/18670 0.04021 0.1617 0.124 MAPK3/PIN1/PRKCA/EMILIN1/EPHB2/BMP4/ANGPT1/CIB1/NRP1/CCR1/PDGFA/RAPGEF1/ARRB2/KLF4/ITGB1BP1/GAS6/HTR2B/CHI3L1/PTPN11/PHB/EZR 21 BP GO:0009308 amine metabolic process 11/819 138/18670 0.04054 0.1624 0.1245 PSMD8/PSMB7/PSMD1/ITGB2/SULT1C2/PSMB6/NAAA/PSMD3/ALDH7A1/PSMD2/PSMB8 11 BP GO:0060759 regulation of response to cytokine stimulus 14/819 190/18670 0.04062 0.1624 0.1245 PXDN/ANGPT1/ADAR/NR1H2/NR1H3/HIF1A/CD24/KLF4/JAK2/GAS6/SOCS3/IRF7/AGPAT1/PTPN11 14 BP GO:0003208 cardiac ventricle morphogenesis 7/819 73/18670 0.04065 0.1624 0.1245 COL11A1/TGFBR1/FOXC1/TPM1/HIF1A/TGFB2/SOX4 7 BP GO:0006283 transcription-coupled nucleotide-excision repair 7/819 73/18670 0.04065 0.1624 0.1245 POLR2L/POLR2E/RFC3/RPA3/HMGN1/COPS8/POLD2 7 BP GO:0043627 response to estrogen 7/819 73/18670 0.04065 0.1624 0.1245 TRIM25/LDHA/WBP2/ARPC1B/CD24/IL4R/TNFRSF11B 7 BP GO:0002828 regulation of type 2 immune response 4/819 30/18670 0.04072 0.1624 0.1245 RSAD2/SOCS5/IL4R/HLX 4 BP GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 4/819 30/18670 0.04072 0.1624 0.1245 SERPINH1/COL14A1/COL6A3/COL7A1 4 BP GO:0010743 regulation of macrophage derived foam cell differentiation 4/819 30/18670 0.04072 0.1624 0.1245 ABCG1/NR1H2/NR1H3/ITGB3 4 BP GO:0032728 positive regulation of interferon-beta production 4/819 30/18670 0.04072 0.1624 0.1245 POLR3D/POLR3G/IRF7/PTPN11 4 BP GO:0042759 long-chain fatty acid biosynthetic process 4/819 30/18670 0.04072 0.1624 0.1245 PLP1/CYP3A4/MYO5A/GPX4 4 BP GO:0045948 positive regulation of translational initiation 4/819 30/18670 0.04072 0.1624 0.1245 HABP4/MTOR/RPS6KB2/NCK1 4 BP GO:0090314 positive regulation of protein targeting to membrane 4/819 30/18670 0.04072 0.1624 0.1245 CEMIP/ITGB2/CIB1/ITGB1BP1 4 BP GO:0017001 antibiotic catabolic process 6/819 58/18670 0.04097 0.163 0.125 RENBP/PXDN/GPX3/GNPDA1/ALDH2/CAT 6 BP GO:0042093 T-helper cell differentiation 6/819 58/18670 0.04097 0.163 0.125 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:1904589 regulation of protein import 6/819 58/18670 0.04097 0.163 0.125 BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/PIK3R2 6 BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 9/819 105/18670 0.04113 0.1635 0.1254 TXN/ANGPT1/NTRK2/PRKD1/HAX1/ARRB2/GAS6/BCL2/CAMK1 9 BP GO:0046427 positive regulation of JAK-STAT cascade 8/819 89/18670 0.04144 0.1643 0.126 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3 8 BP GO:0055013 cardiac muscle cell development 8/819 89/18670 0.04144 0.1643 0.126 PIN1/BMP4/MAML1/CAV3/RGS2/MTOR/MAP2K4/SORBS2 8 BP GO:0097306 cellular response to alcohol 8/819 89/18670 0.04144 0.1643 0.126 GRAMD1B/ADCY8/ADCY7/ADAM15/KLF4/KCNMB1/TNC/FOXO3 8 BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 13/819 173/18670 0.04149 0.1643 0.126 MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/TGFB2/ROR2/MAP2K4/PLCB1/PKN1 13 BP GO:0031503 protein-containing complex localization 19/819 281/18670 0.04149 0.1643 0.126 THOC1/NACC2/KLHL21/EXOC3/FKBP4/GPC4/DDX39A/ITGB3/NUP205/NUP93/NUP153/RRS1/TERF2/SEC13/RAB8A/AP2B1/SRSF7/AGFG1/EZR 19 BP GO:0003414 chondrocyte morphogenesis involved in endochondral bone morphogenesis 3/819 18/18670 0.04197 0.1652 0.1267 COL14A1/COL6A3/COL7A1 3 BP GO:0003429 growth plate cartilage chondrocyte morphogenesis 3/819 18/18670 0.04197 0.1652 0.1267 COL14A1/COL6A3/COL7A1 3 BP GO:0010878 cholesterol storage 3/819 18/18670 0.04197 0.1652 0.1267 ABCG1/NR1H2/NR1H3 3 BP GO:0030809 negative regulation of nucleotide biosynthetic process 3/819 18/18670 0.04197 0.1652 0.1267 NUPR1/FBP1/STAT3 3 BP GO:0035089 establishment of apical/basal cell polarity 3/819 18/18670 0.04197 0.1652 0.1267 PTK7/FSCN1/LAMA1 3 BP GO:0048268 clathrin coat assembly 3/819 18/18670 0.04197 0.1652 0.1267 HIP1R/CLTB/AP2B1 3 BP GO:0090171 chondrocyte morphogenesis 3/819 18/18670 0.04197 0.1652 0.1267 COL14A1/COL6A3/COL7A1 3 BP GO:1900372 negative regulation of purine nucleotide biosynthetic process 3/819 18/18670 0.04197 0.1652 0.1267 NUPR1/FBP1/STAT3 3 BP GO:1905276 regulation of epithelial tube formation 3/819 18/18670 0.04197 0.1652 0.1267 PTK7/FZD2/FZD1 3 BP GO:0030856 regulation of epithelial cell differentiation 12/819 156/18670 0.0421 0.1654 0.1269 SFRP4/VDR/ARNTL/RFX3/BMP4/FOXC1/WWTR1/CD24/ZFP36/BAD/SULT2B1/PRKX 12 BP GO:0034101 erythrocyte homeostasis 10/819 122/18670 0.0421 0.1654 0.1269 ISG15/BMP4/ADAR/HIF1A/EPAS1/PRMT1/STAT3/JAK2/ZFP36/FOXO3 10 BP GO:0006720 isoprenoid metabolic process 11/819 139/18670 0.04236 0.1661 0.1274 RARRES2/CYP1B1/ADH1C/HSPG2/CYP3A4/ADH1A/ADH1B/GPC4/DPM2/ALDH1A3/SDC4 11 BP GO:0003416 endochondral bone growth 5/819 44/18670 0.04249 0.1661 0.1274 COMP/COL14A1/COL6A3/COL7A1/DDR2 5 BP GO:0007019 microtubule depolymerization 5/819 44/18670 0.04249 0.1661 0.1274 CIB1/CAMSAP2/MAP1A/KIF2C/CKAP5 5 BP GO:0038084 vascular endothelial growth factor signaling pathway 5/819 44/18670 0.04249 0.1661 0.1274 FOXC1/VEGFC/PRKD1/NRP1/NRP2 5 BP GO:0042987 amyloid precursor protein catabolic process 5/819 44/18670 0.04249 0.1661 0.1274 CLN3/PIN1/ABCG1/SPON1/BIN1 5 BP GO:0071622 regulation of granulocyte chemotaxis 5/819 44/18670 0.04249 0.1661 0.1274 MAPK3/RARRES2/THBS4/THBS1/BST1 5 BP GO:0006457 protein folding 16/819 227/18670 0.0425 0.1661 0.1274 CRYAB/GRN/TBCE/HSPA5/HSPA2/FKBP4/GNB5/PPIB/TRAP1/DNAJC2/DNAJB5/BAG1/CCT7/NUDC/TTC1/LMAN1 16 BP GO:0045930 negative regulation of mitotic cell cycle 22/819 338/18670 0.04282 0.1673 0.1283 NACC2/PSMD8/PSMB7/BMP4/FOXC1/PSMD1/BCL2L1/FAP/PSMB6/PRMT1/KLF4/SYF2/BCL2/ANAPC15/PSMD3/SOX4/IK/CTDSP2/PSMD2/PSMB8/CDKN2A/XPC 22 BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 7/819 74/18670 0.04327 0.1687 0.1294 IL18R1/STAT3/RSAD2/SOCS5/IL4R/MTOR/HLX 7 BP GO:1900076 regulation of cellular response to insulin stimulus 7/819 74/18670 0.04327 0.1687 0.1294 ENPP1/PIK3R1/GRB10/PRKCB/SOCS3/PTPN11/NCK1 7 BP GO:1901616 organic hydroxy compound catabolic process 7/819 74/18670 0.04327 0.1687 0.1294 SYNJ2/SORD/CYP27A1/FAH/INPP5E/ALDH2/TPI1 7 BP GO:0046849 bone remodeling 8/819 90/18670 0.04381 0.1706 0.1308 GREM1/PLEKHM1/PRKCA/GJA1/RASSF2/ITGB3/TNFRSF11B/TCIRG1 8 BP GO:0001764 neuron migration 12/819 157/18670 0.04385 0.1706 0.1308 COL3A1/SATB2/CXCL12/GJA1/NTRK2/CHL1/NRP1/ITGA3/STAT3/GAS6/PEX7/NRP2 12 BP GO:0043271 negative regulation of ion transport 12/819 157/18670 0.04385 0.1706 0.1308 SFRP4/GSTO1/CLIC2/THBS1/EPHB2/GNB5/GPM6B/CAV3/RGS2/MTOR/BCL2/BIN1 12 BP GO:0001836 release of cytochrome c from mitochondria 6/819 59/18670 0.04399 0.1707 0.1309 GGCT/HRK/BCL2L1/ARRB2/BAD/BCL2 6 BP GO:1902883 negative regulation of response to oxidative stress 6/819 59/18670 0.04399 0.1707 0.1309 PYCR1/TXN/HIF1A/MET/TRAP1/FZD1 6 BP GO:2000351 regulation of endothelial cell apoptotic process 6/819 59/18670 0.04399 0.1707 0.1309 THBS1/RAMP2/ANGPT1/SCG2/GAS6/FOXO3 6 BP GO:0071621 granulocyte chemotaxis 10/819 123/18670 0.04411 0.1708 0.131 MAPK3/RARRES2/THBS4/THBS1/ITGA1/SCG2/ITGB2/PDE4B/BST1/TGFB2 10 BP GO:0033865 nucleoside bisphosphate metabolic process 11/819 140/18670 0.04423 0.1708 0.131 ENPP1/ACOT13/HMGCL/OGDH/ELOVL2/SULT1C2/PDK1/TECR/SULT2B1/COASY/PDK2 11 BP GO:0033875 ribonucleoside bisphosphate metabolic process 11/819 140/18670 0.04423 0.1708 0.131 ENPP1/ACOT13/HMGCL/OGDH/ELOVL2/SULT1C2/PDK1/TECR/SULT2B1/COASY/PDK2 11 BP GO:0034032 purine nucleoside bisphosphate metabolic process 11/819 140/18670 0.04423 0.1708 0.131 ENPP1/ACOT13/HMGCL/OGDH/ELOVL2/SULT1C2/PDK1/TECR/SULT2B1/COASY/PDK2 11 BP GO:0042737 drug catabolic process 11/819 140/18670 0.04423 0.1708 0.131 RENBP/OXCT1/PXDN/PCBD1/QDPR/CYP3A4/FAH/GPX3/GNPDA1/ALDH2/CAT 11 BP GO:0046330 positive regulation of JNK cascade 11/819 140/18670 0.04423 0.1708 0.131 MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/MAP4K2/ROR2/MAP2K4/PLCB1/PKN1 11 BP GO:1903364 positive regulation of cellular protein catabolic process 11/819 140/18670 0.04423 0.1708 0.131 CTSC/USP5/RAD23A/NUPR1/RNF144A/VPS11/CAV3/PTTG1IP/SOCS5/RCHY1/EZR 11 BP GO:0002695 negative regulation of leukocyte activation 13/819 175/18670 0.0448 0.1729 0.1326 THOC1/GRN/BMP4/NR1H3/ABR/TNFRSF14/IL13RA2/SOCS5/IL4R/PAWR/SDC4/PKN1/HLX 13 BP GO:0003401 axis elongation 4/819 31/18670 0.04519 0.1731 0.1327 BMP4/PTK7/WNT11/TNC 4 BP GO:0006482 protein demethylation 4/819 31/18670 0.04519 0.1731 0.1327 KDM5B/PHF2/KDM6A/HSF4 4 BP GO:0007202 activation of phospholipase C activity 4/819 31/18670 0.04519 0.1731 0.1327 NTRK2/LPAR1/HTR2B/EDNRA 4 BP GO:0008214 protein dealkylation 4/819 31/18670 0.04519 0.1731 0.1327 KDM5B/PHF2/KDM6A/HSF4 4 BP GO:0010762 regulation of fibroblast migration 4/819 31/18670 0.04519 0.1731 0.1327 THBS1/DDR2/ITGB1BP1/SDC4 4 BP GO:0035767 endothelial cell chemotaxis 4/819 31/18670 0.04519 0.1731 0.1327 THBS1/PRKD1/NRP1/MET 4 BP GO:0040018 positive regulation of multicellular organism growth 4/819 31/18670 0.04519 0.1731 0.1327 GHR/PPIB/BCL2/EZR 4 BP GO:0090075 relaxation of muscle 4/819 31/18670 0.04519 0.1731 0.1327 ATP2A2/PDE4B/ATP1B1/RGS2 4 BP GO:0090659 walking behavior 4/819 31/18670 0.04519 0.1731 0.1327 CTNS/SPG11/ARRB2/GLRB 4 BP GO:0099625 ventricular cardiac muscle cell membrane repolarization 4/819 31/18670 0.04519 0.1731 0.1327 GJA1/KCND3/SNTA1/CAV3 4 BP GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 4/819 31/18670 0.04519 0.1731 0.1327 CXCL12/BCL2L1/SNAI2/BCL2 4 BP GO:0043467 regulation of generation of precursor metabolites and energy 12/819 158/18670 0.04565 0.1747 0.134 ENPP1/NUPR1/FBP1/HIF1A/NUP205/NUP93/TRAP1/NUP153/STAT3/SEC13/MTOR/COX7A2 12 BP GO:0001974 blood vessel remodeling 5/819 45/18670 0.04614 0.176 0.135 BGN/FOXC1/TGM2/ABR/EPAS1 5 BP GO:0031018 endocrine pancreas development 5/819 45/18670 0.04614 0.176 0.135 ARNTL/RFX3/BMP4/BAD/SOX4 5 BP GO:0009411 response to UV 11/819 141/18670 0.04617 0.176 0.135 MAP3K4/PIK3R1/IL12A/TYR/PTPRK/HMGN1/BCL2/CAT/CASP9/XPC/CREBBP 11 BP GO:0008637 apoptotic mitochondrial changes 10/819 124/18670 0.04618 0.176 0.135 HIP1R/IFIT2/GGCT/HRK/BCL2L1/GCLM/NMT1/ARRB2/BAD/BCL2 10 BP GO:0019751 polyol metabolic process 10/819 124/18670 0.04618 0.176 0.135 SYNJ2/SORD/PCBD1/QDPR/CYP3A4/CYP27A1/ASAH1/INPP5E/PLCB1/TPI1 10 BP GO:0051209 release of sequestered calcium ion into cytosol 10/819 124/18670 0.04618 0.176 0.135 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/PLCB1/CACNA1C/HTR2B 10 BP GO:1901991 negative regulation of mitotic cell cycle phase transition 17/819 248/18670 0.04653 0.1772 0.1359 NACC2/PSMD8/PSMB7/PSMD1/PSMB6/PRMT1/KLF4/SYF2/BCL2/ANAPC15/PSMD3/SOX4/IK/CTDSP2/PSMD2/PSMB8/CDKN2A 17 BP GO:0006403 RNA localization 16/819 230/18670 0.04691 0.1785 0.1369 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/TERF2/ZFP36/SEC13/EXOSC2/NHP2/CCT7/CKAP5/SRSF7/AGFG1/MX2 16 BP GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 6/819 60/18670 0.04714 0.1789 0.1372 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:0018149 peptide cross-linking 6/819 60/18670 0.04714 0.1789 0.1372 BGN/COL3A1/THBS1/TGM2/SPRR2D/TGM4 6 BP GO:0046794 transport of virus 6/819 60/18670 0.04714 0.1789 0.1372 NUP205/NUP93/NUP153/SEC13/TSG101/KPNA3 6 BP GO:0120193 tight junction organization 6/819 60/18670 0.04714 0.1789 0.1372 RAMP2/GJA1/TGFBR1/SNAI2/ARL2/WNT11 6 BP GO:0006665 sphingolipid metabolic process 12/819 159/18670 0.04751 0.1801 0.1382 PLA2G15/ST3GAL5/CTSA/CLN3/ESYT1/ELOVL2/PRKD1/GM2A/SERINC5/ASAH1/TECR/PPP2R1A 12 BP GO:0051403 stress-activated MAPK cascade 19/819 286/18670 0.04804 0.181 0.1388 MAPK3/MAP3K4/CRYAB/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/RAPGEF1/CAV3/TGFB2/ZFP36/ROR2/MAP2K4/PLCB1/EZR/PKN1 19 BP GO:1900542 regulation of purine nucleotide metabolic process 11/819 142/18670 0.04815 0.181 0.1388 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/COX7A2/PDK2 11 BP GO:0002363 alpha-beta T cell lineage commitment 3/819 19/18670 0.04827 0.181 0.1388 STAT3/MTOR/BCL2 3 BP GO:0003422 growth plate cartilage morphogenesis 3/819 19/18670 0.04827 0.181 0.1388 COL14A1/COL6A3/COL7A1 3 BP GO:0010523 negative regulation of calcium ion transport into cytosol 3/819 19/18670 0.04827 0.181 0.1388 GSTO1/CLIC2/BCL2 3 BP GO:0016082 synaptic vesicle priming 3/819 19/18670 0.04827 0.181 0.1388 SV2A/NAPA/UNC13B 3 BP GO:0032288 myelin assembly 3/819 19/18670 0.04827 0.181 0.1388 FIG4/PMP22/PIKFYVE 3 BP GO:0034312 diol biosynthetic process 3/819 19/18670 0.04827 0.181 0.1388 PCBD1/QDPR/ASAH1 3 BP GO:0035493 SNARE complex assembly 3/819 19/18670 0.04827 0.181 0.1388 VPS41/VPS11/VAMP3 3 BP GO:0042789 mRNA transcription by RNA polymerase II 3/819 19/18670 0.04827 0.181 0.1388 LMO2/HIF1A/STAT3 3 BP GO:0046597 negative regulation of viral entry into host cell 3/819 19/18670 0.04827 0.181 0.1388 TRIM25/GSN/PTX3 3 BP GO:0046653 tetrahydrofolate metabolic process 3/819 19/18670 0.04827 0.181 0.1388 MTHFD2/GART/MTHFD1 3 BP GO:0060004 reflex 3/819 19/18670 0.04827 0.181 0.1388 GJA1/GLRB/ALDH1A3 3 BP GO:2000010 positive regulation of protein localization to cell surface 3/819 19/18670 0.04827 0.181 0.1388 TM9SF4/GPD1L/MAP1A 3 BP GO:2000696 regulation of epithelial cell differentiation involved in kidney development 3/819 19/18670 0.04827 0.181 0.1388 WWTR1/CD24/PRKX 3 BP GO:0001959 regulation of cytokine-mediated signaling pathway 13/819 177/18670 0.04829 0.181 0.1388 PXDN/ANGPT1/ADAR/NR1H2/NR1H3/HIF1A/CD24/JAK2/GAS6/SOCS3/IRF7/AGPAT1/PTPN11 13 BP GO:0009063 cellular amino acid catabolic process 10/819 125/18670 0.04832 0.181 0.1388 PCBD1/HMGCL/DDAH2/OGDH/QDPR/AUH/FAH/ALDH7A1/CRYM/BCAT2 10 BP GO:0043588 skin development 26/819 419/18670 0.04832 0.181 0.1388 VDR/COL5A2/COL3A1/COL1A2/COL1A1/COMP/CLDN4/FOXC1/PALLD/MYO5A/MET/ITGA3/FZD6/PDGFA/FLNB/TGFB2/CAPNS1/ITGA6/ZFP36/ASAH1/TSG101/SPRR2D/BCL2/ITGA2/KRT18/PIP5K1A 26 BP GO:0010876 lipid localization 25/819 400/18670 0.04859 0.1819 0.1395 ENPP1/ATP8A1/ABCA3/THBS1/KDM5B/GRAMD1B/ESYT1/ABCG1/ABHD5/NR1H2/GM2A/NR1H3/ATP11B/MEST/ABCC4/GULP1/PLTP/ITGB3/KCNN4/PNPLA2/SIGMAR1/STOML1/PTPN11/TMF1/VLDLR 25 BP GO:0019319 hexose biosynthetic process 8/819 92/18670 0.04882 0.1821 0.1397 SORD/KAT2B/FBP1/PDK2/PGM1/PER2/TPI1/MDH2 8 BP GO:1904894 positive regulation of STAT cascade 8/819 92/18670 0.04882 0.1821 0.1397 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3 8 BP GO:0031334 positive regulation of protein complex assembly 18/819 268/18670 0.04883 0.1821 0.1397 HIP1R/HRK/CDC42EP1/MET/RPA3/ARPC1B/GSN/FSCN1/ARL2/CAV3/CLIP1/MTOR/UNC13B/BIN1/GMFG/RHOBTB2/LMOD1/NCK1 18 BP GO:0046902 regulation of mitochondrial membrane permeability 7/819 76/18670 0.04884 0.1821 0.1397 HIP1R/BCL2L1/NMT1/STAT3/BAD/BCL2/HEBP2 7 BP GO:1901264 carbohydrate derivative transport 7/819 76/18670 0.04884 0.1821 0.1397 SLC35D2/ABCG1/GJA1/GUK1/SLC29A1/P2RY2/VLDLR 7 BP GO:0002819 regulation of adaptive immune response 12/819 160/18670 0.04941 0.184 0.1411 THOC1/IL18R1/ADCY7/IL12A/TNFRSF14/RSAD2/SOCS5/IL6ST/IL4R/IRF7/PKN1/HLX 12 BP GO:0046661 male sex differentiation 12/819 160/18670 0.04941 0.184 0.1411 ASB1/GJA1/TGFBR1/NUPR1/ADAM15/BCL2L1/FKBP4/TGFB2/ROR2/BCL2/EIF2S2/TMF1 12 BP GO:0051648 vesicle localization 20/819 306/18670 0.04983 0.1841 0.1412 CTSC/TRAK2/CLN3/ATP2A2/SV2A/RAB27B/KIAA1107/GOSR2/MYO5A/NAPA/SPG11/DYNC1I1/COL7A1/MAP4K2/ARFGAP2/SEC13/PRKCB/UNC13B/LMAN1/TMED2 20 BP GO:0001569 branching involved in blood vessel morphogenesis 4/819 32/18670 0.04992 0.1841 0.1412 PLXND1/NRP1/COL4A1/EDNRA 4 BP GO:0003176 aortic valve development 4/819 32/18670 0.04992 0.1841 0.1412 EMILIN1/BMP4/ELN/SNAI2 4 BP GO:0006739 NADP metabolic process 4/819 32/18670 0.04992 0.1841 0.1412 NADK/IDH2/FMO1/FMO2 4 BP GO:0051085 chaperone cofactor-dependent protein refolding 4/819 32/18670 0.04992 0.1841 0.1412 HSPA5/HSPA2/DNAJB5/BAG1 4 BP GO:1900745 positive regulation of p38MAPK cascade 4/819 32/18670 0.04992 0.1841 0.1412 MAP3K4/SASH1/MAP3K5/PRMT1 4 BP GO:0001504 neurotransmitter uptake 5/819 46/18670 0.04998 0.1841 0.1412 SLC29A1/ITGB3/GPM6B/RGS2/PER2 5 BP GO:0001754 eye photoreceptor cell differentiation 5/819 46/18670 0.04998 0.1841 0.1412 NAGLU/NTRK2/TUG1/THY1/STAT3 5 BP GO:0006221 pyrimidine nucleotide biosynthetic process 5/819 46/18670 0.04998 0.1841 0.1412 NME3/CDS1/CDS2/AGPAT1/CTPS1 5 BP GO:0006984 ER-nucleus signaling pathway 5/819 46/18670 0.04998 0.1841 0.1412 ATP2A2/IGFBP1/HSPA5/MBTPS1/NCK1 5 BP GO:0014075 response to amine 5/819 46/18670 0.04998 0.1841 0.1412 UROS/RGS2/ITGA2/ASIC1/GRIN2A 5 BP GO:0022602 ovulation cycle process 5/819 46/18670 0.04998 0.1841 0.1412 HSPA5/TGFB2/ARRB2/PTX3/FOXO3 5 BP GO:0032369 negative regulation of lipid transport 5/819 46/18670 0.04998 0.1841 0.1412 THBS1/NR1H2/NR1H3/ITGB3/PTPN11 5 BP GO:0035088 establishment or maintenance of apical/basal cell polarity 5/819 46/18670 0.04998 0.1841 0.1412 PTK7/ARF4/FSCN1/LAMA1/WNT11 5 BP GO:0061245 establishment or maintenance of bipolar cell polarity 5/819 46/18670 0.04998 0.1841 0.1412 PTK7/ARF4/FSCN1/LAMA1/WNT11 5 BP GO:1990928 response to amino acid starvation 5/819 46/18670 0.04998 0.1841 0.1412 MAPK3/RRAGD/PRKD1/MAP3K5/MTOR 5 BP GO:0042445 hormone metabolic process 16/819 232/18670 0.05002 0.1842 0.1412 VDR/PCSK5/STC2/CYP1B1/TCF7L2/FDXR/ADH1C/GHR/CYP3A4/ADH1A/CYP27A1/ADH1B/HIF1A/ALDH1A3/PTPN11/CRYM 16 BP GO:0006289 nucleotide-excision repair 9/819 109/18670 0.05017 0.1846 0.1416 POLR2L/POLR2E/RAD23A/RFC3/RPA3/HMGN1/COPS8/POLD2/XPC 9 BP GO:0002287 alpha-beta T cell activation involved in immune response 6/819 61/18670 0.05043 0.1849 0.1418 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:0002293 alpha-beta T cell differentiation involved in immune response 6/819 61/18670 0.05043 0.1849 0.1418 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:0032370 positive regulation of lipid transport 6/819 61/18670 0.05043 0.1849 0.1418 ATP8A1/ABCG1/NR1H2/NR1H3/PLTP/TMF1 6 BP GO:0045604 regulation of epidermal cell differentiation 6/819 61/18670 0.05043 0.1849 0.1418 SFRP4/VDR/BMP4/FOXC1/ZFP36/SULT2B1 6 BP GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 6/819 61/18670 0.05043 0.1849 0.1418 NACC2/NUPR1/BCL2L1/BAD/BCL2/NCK1 6 BP GO:0051283 negative regulation of sequestering of calcium ion 10/819 126/18670 0.05052 0.1851 0.142 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/PLCB1/CACNA1C/HTR2B 10 BP GO:0035967 cellular response to topologically incorrect protein 12/819 161/18670 0.05136 0.1881 0.1442 STC2/CREB3L2/KDELR3/ATP6V0D1/PIK3R1/IGFBP1/HSPA5/HSPA2/GOSR2/MBTPS1/CTDSP2/NCK1 12 BP GO:0000045 autophagosome assembly 8/819 93/18670 0.05146 0.1881 0.1442 NSFL1C/NUPR1/ATG2A/TMEM41B/PIK3C3/ATG4A/MAP1LC3B/PIKFYVE 8 BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 8/819 93/18670 0.05146 0.1881 0.1442 PSMD8/PSMB7/PSMD1/PSMB6/SYF2/PSMD3/PSMD2/PSMB8 8 BP GO:0032092 positive regulation of protein binding 8/819 93/18670 0.05146 0.1881 0.1442 HIP1R/TCF7L2/PIN1/BMP4/PLXND1/NRP1/MAPRE3/SPON1 8 BP GO:0006809 nitric oxide biosynthetic process 7/819 77/18670 0.05178 0.1889 0.1448 CYP1B1/DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 7 BP GO:0008344 adult locomotory behavior 7/819 77/18670 0.05178 0.1889 0.1448 CTNS/CXCL12/CHL1/TMOD1/EPS8/ARRB2/GLRB 7 BP GO:0045165 cell fate commitment 18/819 270/18670 0.05178 0.1889 0.1448 SATB2/TCF7L2/FZD7/BMP4/GAP43/TGFBR1/SOX5/NRP1/EPAS1/TEAD3/STAT3/NOTCH3/KLF4/WNT11/MTOR/ROR2/BCL2/ITGB1 18 BP GO:0032388 positive regulation of intracellular transport 15/819 215/18670 0.05202 0.1895 0.1453 CEMIP/TCF7L2/PIK3R1/ITGB2/CIB1/TM9SF4/VPS11/PIK3R2/ITGB1BP1/GAS6/IL4R/RAB29/UNC13B/EZR/CAMK1 15 BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 15/819 215/18670 0.05202 0.1895 0.1453 MAPK3/PRKCA/BMP4/ANGPT1/CIB1/NRP1/CCR1/PDGFA/RAPGEF1/ARRB2/GAS6/HTR2B/CHI3L1/PTPN11/PHB 15 BP GO:0032368 regulation of lipid transport 10/819 127/18670 0.05279 0.1922 0.1474 ATP8A1/THBS1/KDM5B/ABCG1/NR1H2/NR1H3/PLTP/ITGB3/PTPN11/TMF1 10 BP GO:0006220 pyrimidine nucleotide metabolic process 6/819 62/18670 0.05386 0.1941 0.1488 NME3/MBD4/CDS1/CDS2/AGPAT1/CTPS1 6 BP GO:0032623 interleukin-2 production 6/819 62/18670 0.05386 0.1941 0.1488 IL1RAP/PDE4B/ZFP36/SPTBN1/PAWR/EZR 6 BP GO:0048857 neural nucleus development 6/819 62/18670 0.05386 0.1941 0.1488 HSPA5/PLP1/CKB/NDUFS3/BCL2/ALDH1A3 6 BP GO:0046890 regulation of lipid biosynthetic process 14/819 198/18670 0.05398 0.1941 0.1488 VDR/TM7SF2/IGFBP7/LPGAT1/ABCG1/NR1H2/NR1H3/SNAI2/PDGFA/ASAH1/MTOR/MBTPS1/HTR2B/NFYB 14 BP GO:0060541 respiratory system development 14/819 198/18670 0.05398 0.1941 0.1488 MAPK3/SPARC/BMP4/PTK7/LOX/ITGA3/LIPA/EPAS1/PDGFA/LAMA1/WNT11/TNC/CHI3L1/ALDH1A3 14 BP GO:0021695 cerebellar cortex development 5/819 47/18670 0.054 0.1941 0.1488 NAGLU/B4GALT2/HSPA5/UQCRQ/PTPN11 5 BP GO:0048066 developmental pigmentation 5/819 47/18670 0.054 0.1941 0.1488 ENPP1/RAB32/MYO5A/TYR/BCL2 5 BP GO:0061614 pri-miRNA transcription by RNA polymerase II 5/819 47/18670 0.054 0.1941 0.1488 BMP4/HIF1A/STAT3/TGFB2/KLF4 5 BP GO:0070169 positive regulation of biomineral tissue development 5/819 47/18670 0.054 0.1941 0.1488 ISG15/BMP4/FBN2/TFAP2A/GPM6B 5 BP GO:0098868 bone growth 5/819 47/18670 0.054 0.1941 0.1488 COMP/COL14A1/COL6A3/COL7A1/DDR2 5 BP GO:1903115 regulation of actin filament-based movement 5/819 47/18670 0.054 0.1941 0.1488 ATP2A2/PDE4B/CAV3/CACNA1C/BIN1 5 BP GO:2000107 negative regulation of leukocyte apoptotic process 5/819 47/18670 0.054 0.1941 0.1488 CXCL12/BMP4/HIF1A/GAS6/IRF7 5 BP GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 5/819 47/18670 0.054 0.1941 0.1488 UNC5B/BCL2L1/SNAI2/BCL2/PPP2R1A 5 BP GO:0006906 vesicle fusion 8/819 94/18670 0.05419 0.1941 0.1488 VPS41/TBC1D4/VPS11/GOSR2/SPG11/RAB8A/TAP1/VAMP3 8 BP GO:0007605 sensory perception of sound 11/819 145/18670 0.05447 0.1941 0.1488 LRIG1/CEMIP/COL11A1/COL1A1/SNAI2/TFAP2A/DIAPH1/SERPINB6/ALDH7A1/CLIC5/CRYM 11 BP GO:0000271 polysaccharide biosynthetic process 7/819 78/18670 0.05484 0.1941 0.1488 ENPP1/NDST1/HAS2/EXT1/MTOR/PGM1/PER2 7 BP GO:0021954 central nervous system neuron development 7/819 78/18670 0.05484 0.1941 0.1488 CDH11/EPHB2/ADARB1/NTRK2/NRP1/UQCRQ/NRP2 7 BP GO:0031016 pancreas development 7/819 78/18670 0.05484 0.1941 0.1488 ARNTL/TCF7L2/RFX3/BMP4/MET/BAD/SOX4 7 BP GO:0031112 positive regulation of microtubule polymerization or depolymerization 4/819 33/18670 0.05492 0.1941 0.1488 MET/ARL2/CAV3/CLIP1 4 BP GO:0033028 myeloid cell apoptotic process 4/819 33/18670 0.05492 0.1941 0.1488 PIK3CB/IRF7/BCL2/CDKN2A 4 BP GO:0061036 positive regulation of cartilage development 4/819 33/18670 0.05492 0.1941 0.1488 BMP1/BMP4/SOX5/LOXL2 4 BP GO:2000352 negative regulation of endothelial cell apoptotic process 4/819 33/18670 0.05492 0.1941 0.1488 RAMP2/ANGPT1/SCG2/GAS6 4 BP GO:2000758 positive regulation of peptidyl-lysine acetylation 4/819 33/18670 0.05492 0.1941 0.1488 MAPK3/SNAI2/WBP2/SOX4 4 BP GO:0002320 lymphoid progenitor cell differentiation 3/819 20/18670 0.05499 0.1941 0.1488 BMP4/BCL2/SOX4 3 BP GO:0002374 cytokine secretion involved in immune response 3/819 20/18670 0.05499 0.1941 0.1488 MAPK3/ANGPT1/TNFRSF14 3 BP GO:0002827 positive regulation of T-helper 1 type immune response 3/819 20/18670 0.05499 0.1941 0.1488 IL18R1/SOCS5/HLX 3 BP GO:0010560 positive regulation of glycoprotein biosynthetic process 3/819 20/18670 0.05499 0.1941 0.1488 TCF7L2/PLCB1/PAWR 3 BP GO:0010592 positive regulation of lamellipodium assembly 3/819 20/18670 0.05499 0.1941 0.1488 TWF2/FSCN1/MTOR 3 BP GO:0030903 notochord development 3/819 20/18670 0.05499 0.1941 0.1488 COL5A2/WNT11/KDM6A 3 BP GO:0031936 negative regulation of chromatin silencing 3/819 20/18670 0.05499 0.1941 0.1488 PHF2/ASF1A/HMGA1 3 BP GO:0033194 response to hydroperoxide 3/819 20/18670 0.05499 0.1941 0.1488 PRKD1/JAK2/GPX3 3 BP GO:0033630 positive regulation of cell adhesion mediated by integrin 3/819 20/18670 0.05499 0.1941 0.1488 CIB1/PODXL/TGFB2 3 BP GO:0034104 negative regulation of tissue remodeling 3/819 20/18670 0.05499 0.1941 0.1488 GREM1/ABR/TNFRSF11B 3 BP GO:0034393 positive regulation of smooth muscle cell apoptotic process 3/819 20/18670 0.05499 0.1941 0.1488 IL12A/MAP2K4/CDKN2A 3 BP GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 3/819 20/18670 0.05499 0.1941 0.1488 STAT3/MTOR/BCL2 3 BP GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 3/819 20/18670 0.05499 0.1941 0.1488 SOCS5/IL4R/HLX 3 BP GO:0046655 folic acid metabolic process 3/819 20/18670 0.05499 0.1941 0.1488 MTHFD2/FOLR2/MTHFD1 3 BP GO:0048745 smooth muscle tissue development 3/819 20/18670 0.05499 0.1941 0.1488 COL3A1/BMP4/MYLK 3 BP GO:0050860 negative regulation of T cell receptor signaling pathway 3/819 20/18670 0.05499 0.1941 0.1488 THY1/PAWR/EZR 3 BP GO:0061162 establishment of monopolar cell polarity 3/819 20/18670 0.05499 0.1941 0.1488 PTK7/FSCN1/LAMA1 3 BP GO:0070987 error-free translesion synthesis 3/819 20/18670 0.05499 0.1941 0.1488 RFC3/RPA3/RCHY1 3 BP GO:0086014 atrial cardiac muscle cell action potential 3/819 20/18670 0.05499 0.1941 0.1488 GJA1/GJC1/CACNA1C 3 BP GO:0086026 atrial cardiac muscle cell to AV node cell signaling 3/819 20/18670 0.05499 0.1941 0.1488 GJA1/GJC1/CACNA1C 3 BP GO:0086066 atrial cardiac muscle cell to AV node cell communication 3/819 20/18670 0.05499 0.1941 0.1488 GJA1/GJC1/CACNA1C 3 BP GO:0097503 sialylation 3/819 20/18670 0.05499 0.1941 0.1488 ST3GAL5/ST6GALNAC2/ST6GAL1 3 BP GO:1905523 positive regulation of macrophage migration 3/819 20/18670 0.05499 0.1941 0.1488 MAPK3/RARRES2/THBS1 3 BP GO:2000774 positive regulation of cellular senescence 3/819 20/18670 0.05499 0.1941 0.1488 PAWR/HMGA1/CDKN2A 3 BP GO:0051282 regulation of sequestering of calcium ion 10/819 128/18670 0.05513 0.1943 0.149 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/PLCB1/CACNA1C/HTR2B 10 BP GO:0098661 inorganic anion transmembrane transport 9/819 111/18670 0.05514 0.1943 0.149 CLIC2/SLC20A1/CLIC1/CLDN4/CLCN7/GLRB/MTOR/CLCN6/CLIC5 9 BP GO:0008406 gonad development 15/819 217/18670 0.05551 0.1953 0.1498 GJA1/TGFBR1/FOXC1/NUPR1/HSPA5/ADAM15/BCL2L1/INHBB/TGFB2/ARRB2/BCL2/PTX3/FOXO3/EIF2S2/TMF1 15 BP GO:0044242 cellular lipid catabolic process 15/819 217/18670 0.05551 0.1953 0.1498 PLA2G15/ECI1/CYP1B1/PCCB/ABHD5/PLA2G4C/GM2A/AUH/HADH/PNPLA2/PEX7/ASAH1/MTOR/ETFB/ENPP2 15 BP GO:0009101 glycoprotein biosynthetic process 22/819 348/18670 0.05553 0.1953 0.1498 BGN/ST3GAL5/NDST1/CHST7/CHSY1/TRAK2/TCF7L2/ST6GALNAC2/B4GALT2/ITM2B/ST6GAL1/UBE2J1/EXT1/DPM2/BCL2/PLCB1/ACAN/VCAN/PAWR/LMAN1/NCAN/STT3A 22 BP GO:0017038 protein import 14/819 199/18670 0.05583 0.1961 0.1504 ARNTL/BMP4/ANGPT1/PIK3R1/MDFIC/NOLC1/NUP93/NUP153/PIK3R2/STAT3/PTTG1IP/PEX7/MBTPS1/KPNA3 14 BP GO:0010565 regulation of cellular ketone metabolic process 13/819 181/18670 0.05584 0.1961 0.1504 PSMD8/LPGAT1/PSMB7/PSMD1/NR1H2/NR1H3/PSMB6/PDK1/MTOR/PDK2/PSMD3/PSMD2/PSMB8 13 BP GO:0006140 regulation of nucleotide metabolic process 11/819 146/18670 0.05669 0.1989 0.1525 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/PDK1/SEC13/COX7A2/PDK2 11 BP GO:0055123 digestive system development 11/819 146/18670 0.05669 0.1989 0.1525 COL3A1/PCSK5/RARRES2/HIP1R/BMP4/HIF1A/TGFB2/ITGA6/WNT11/BCL2/HLX 11 BP GO:0050810 regulation of steroid biosynthetic process 8/819 95/18670 0.05701 0.1996 0.1531 VDR/TM7SF2/IGFBP7/ABCG1/SNAI2/ASAH1/MBTPS1/NFYB 8 BP GO:0055006 cardiac cell development 8/819 95/18670 0.05701 0.1996 0.1531 PIN1/BMP4/MAML1/CAV3/RGS2/MTOR/MAP2K4/SORBS2 8 BP GO:0061326 renal tubule development 8/819 95/18670 0.05701 0.1996 0.1531 MTSS1/MAGED1/BMP4/WWTR1/CD24/COL4A1/WNT11/BCL2 8 BP GO:0007601 visual perception 15/819 218/18670 0.05732 0.2006 0.1538 CYP1B1/COL11A1/HPS1/COL1A1/GJC1/MYO5A/TYR/EFEMP1/EPAS1/ABLIM1/CNGA3/GLRB/RABGGTA/HSF4/CLIC5 15 BP GO:0035418 protein localization to synapse 6/819 63/18670 0.05742 0.2008 0.154 RAB27B/GPC4/TERF2/RAB8A/MAP1A/GRIN2A 6 BP GO:0044106 cellular amine metabolic process 10/819 129/18670 0.05753 0.2011 0.1542 PSMD8/PSMB7/PSMD1/ITGB2/PSMB6/NAAA/PSMD3/ALDH7A1/PSMD2/PSMB8 10 BP GO:1990748 cellular detoxification 9/819 112/18670 0.05774 0.2017 0.1547 GSTO1/CLIC2/PXDN/TXN/SOD3/GPX4/GPX3/FBLN5/CAT 9 BP GO:0006338 chromatin remodeling 13/819 182/18670 0.05784 0.2017 0.1547 SATB2/KDM5B/SMARCA1/KAT2B/ITGB3BP/POLE3/SUPT4H1/ANP32E/CHD1/KDM6A/SMARCE1/HMGA1/CDKN2A 13 BP GO:0010821 regulation of mitochondrion organization 13/819 182/18670 0.05784 0.2017 0.1547 HIP1R/HRK/BCL2L1/VPS11/HAX1/HIF1A/CLEC16A/VAT1/NMT1/ARRB2/BAD/BCL2/LMAN1 13 BP GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 5/819 48/18670 0.0582 0.2026 0.1554 STAM/SH3GL2/ITGA1/SOCS5/TSG101 5 BP GO:0051972 regulation of telomerase activity 5/819 48/18670 0.0582 0.2026 0.1554 MAPK3/GREM1/MAP3K4/NEK7/KLF4 5 BP GO:0055010 ventricular cardiac muscle tissue morphogenesis 5/819 48/18670 0.0582 0.2026 0.1554 COL11A1/TGFBR1/FOXC1/TPM1/TGFB2 5 BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 12/819 165/18670 0.05969 0.2073 0.159 NACC2/CXCL12/NUPR1/BCL2L1/SNAI2/HIF1A/NDUFS3/TRAP1/PTTG1IP/BAD/BCL2/NCK1 12 BP GO:0002040 sprouting angiogenesis 13/819 183/18670 0.05989 0.2073 0.159 GREM1/THBS1/RAMP2/BMP4/ANGPT1/VEGFC/CIB1/EPHB4/NRP1/LOXL2/KLF4/ITGB1BP1/ITGB1 13 BP GO:1905037 autophagosome organization 8/819 96/18670 0.05992 0.2073 0.159 NSFL1C/NUPR1/ATG2A/TMEM41B/PIK3C3/ATG4A/MAP1LC3B/PIKFYVE 8 BP GO:2001169 regulation of ATP biosynthetic process 8/819 96/18670 0.05992 0.2073 0.159 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13 8 BP GO:0002183 cytoplasmic translational initiation 4/819 34/18670 0.06017 0.2073 0.159 EIF3I/MTOR/EIF2S2/NCK1 4 BP GO:0006409 tRNA export from nucleus 4/819 34/18670 0.06017 0.2073 0.159 NUP205/NUP93/NUP153/SEC13 4 BP GO:0010574 regulation of vascular endothelial growth factor production 4/819 34/18670 0.06017 0.2073 0.159 CYP1B1/HIF1A/SULF1/IL6ST 4 BP GO:0010922 positive regulation of phosphatase activity 4/819 34/18670 0.06017 0.2073 0.159 ITGA1/JAK2/MTOR/ITGA2 4 BP GO:0032148 activation of protein kinase B activity 4/819 34/18670 0.06017 0.2073 0.159 TXN/ITGB1BP1/GAS6/MTOR 4 BP GO:0032212 positive regulation of telomere maintenance via telomerase 4/819 34/18670 0.06017 0.2073 0.159 MAPK3/MAP3K4/NEK7/CCT7 4 BP GO:0032594 protein transport within lipid bilayer 4/819 34/18670 0.06017 0.2073 0.159 CD24/ATP1B1/RAB8A/CLIP1 4 BP GO:0034205 amyloid-beta formation 4/819 34/18670 0.06017 0.2073 0.159 PIN1/ABCG1/SPON1/BIN1 4 BP GO:0048566 embryonic digestive tract development 4/819 34/18670 0.06017 0.2073 0.159 PCSK5/RARRES2/TGFB2/HLX 4 BP GO:0071402 cellular response to lipoprotein particle stimulus 4/819 34/18670 0.06017 0.2073 0.159 ABCG1/ITGB2/SOCS5/ITGB1 4 BP GO:0071431 tRNA-containing ribonucleoprotein complex export from nucleus 4/819 34/18670 0.06017 0.2073 0.159 NUP205/NUP93/NUP153/SEC13 4 BP GO:0098901 regulation of cardiac muscle cell action potential 4/819 34/18670 0.06017 0.2073 0.159 ATP2A2/CAV3/CACNA1C/BIN1 4 BP GO:0060964 regulation of gene silencing by miRNA 9/819 113/18670 0.06042 0.2081 0.1596 POLR2L/POLR2E/BMP4/NUP205/NUP93/NUP153/STAT3/ZFP36/SEC13 9 BP GO:0030032 lamellipodium assembly 6/819 64/18670 0.06112 0.2101 0.1611 TWF2/FSCN1/ABLIM1/MTOR/NCK1/ITGB1 6 BP GO:0032768 regulation of monooxygenase activity 6/819 64/18670 0.06112 0.2101 0.1611 VDR/DDAH2/HIF1A/CAV3/TERF2/HTR2B 6 BP GO:0046782 regulation of viral transcription 6/819 64/18670 0.06112 0.2101 0.1611 POLR2L/POLR2E/MDFIC/SUPT4H1/ZFP36/CHD1 6 BP GO:0140029 exocytic process 7/819 80/18670 0.06128 0.2105 0.1614 SV2A/VPS11/NAPA/RAB8A/UNC13B/VPS45/VAMP3 7 BP GO:0016042 lipid catabolic process 21/819 333/18670 0.06154 0.2111 0.1619 PLA2G15/RARRES2/ECI1/CYP1B1/PCCB/ABHD5/PLA2G4C/GM2A/AUH/CYP3A4/HADH/CYP27A1/LIPA/PNPLA2/PEX7/ASAH1/MTOR/NAAA/ETFB/PLCB1/ENPP2 21 BP GO:0009416 response to light stimulus 20/819 314/18670 0.06166 0.2111 0.1619 CTNS/MAP3K4/PIK3R1/B4GALT2/IL12A/TYR/HIF1A/CDS1/PTPRK/NMT1/HMGN1/MTOR/BCL2/CAT/PER2/CASP9/XPC/GRIN2A/CREBBP/ITGB1 20 BP GO:0016125 sterol metabolic process 12/819 166/18670 0.06191 0.2111 0.1619 TM7SF2/CYP1B1/ABCG1/FDXR/LBR/CYP27A1/LIPA/SULT2B1/MBTPS1/CAT/VLDLR/NFYB 12 BP GO:0003094 glomerular filtration 3/819 21/18670 0.06214 0.2111 0.1619 GJA1/SULF1/GAS6 3 BP GO:0006144 purine nucleobase metabolic process 3/819 21/18670 0.06214 0.2111 0.1619 GART/MTHFD1/GMPR 3 BP GO:0006907 pinocytosis 3/819 21/18670 0.06214 0.2111 0.1619 MAPKAPK3/NR1H2/NR1H3 3 BP GO:0009081 branched-chain amino acid metabolic process 3/819 21/18670 0.06214 0.2111 0.1619 HMGCL/AUH/BCAT2 3 BP GO:0009083 branched-chain amino acid catabolic process 3/819 21/18670 0.06214 0.2111 0.1619 HMGCL/AUH/BCAT2 3 BP GO:0010829 negative regulation of glucose transmembrane transport 3/819 21/18670 0.06214 0.2111 0.1619 ENPP1/GRB10/PRKCB 3 BP GO:0032516 positive regulation of phosphoprotein phosphatase activity 3/819 21/18670 0.06214 0.2111 0.1619 ITGA1/JAK2/MTOR 3 BP GO:0036499 PERK-mediated unfolded protein response 3/819 21/18670 0.06214 0.2111 0.1619 IGFBP1/HSPA5/NCK1 3 BP GO:0042438 melanin biosynthetic process 3/819 21/18670 0.06214 0.2111 0.1619 CTNS/MYO5A/TYR 3 BP GO:0046716 muscle cell cellular homeostasis 3/819 21/18670 0.06214 0.2111 0.1619 LOX/HIF1A/CAV3 3 BP GO:0046827 positive regulation of protein export from nucleus 3/819 21/18670 0.06214 0.2111 0.1619 TCF7L2/GAS6/CAMK1 3 BP GO:0048485 sympathetic nervous system development 3/819 21/18670 0.06214 0.2111 0.1619 NRP1/NRP2/SOX4 3 BP GO:0051900 regulation of mitochondrial depolarization 3/819 21/18670 0.06214 0.2111 0.1619 MYOC/GCLM/BCL2 3 BP GO:0061339 establishment or maintenance of monopolar cell polarity 3/819 21/18670 0.06214 0.2111 0.1619 PTK7/FSCN1/LAMA1 3 BP GO:1903055 positive regulation of extracellular matrix organization 3/819 21/18670 0.06214 0.2111 0.1619 EMILIN1/FSCN1/DDR2 3 BP GO:0051208 sequestering of calcium ion 10/819 131/18670 0.06254 0.2119 0.1625 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/ITPR3/THY1/PLCB1/CACNA1C/HTR2B 10 BP GO:0002686 negative regulation of leukocyte migration 5/819 49/18670 0.06258 0.2119 0.1625 GREM1/CXCL12/EMILIN1/ABR/PLCB1 5 BP GO:0045010 actin nucleation 5/819 49/18670 0.06258 0.2119 0.1625 HIP1R/ARPC1B/GSN/GMFG/LMOD1 5 BP GO:0048546 digestive tract morphogenesis 5/819 49/18670 0.06258 0.2119 0.1625 BMP4/HIF1A/WNT11/BCL2/HLX 5 BP GO:0071825 protein-lipid complex subunit organization 5/819 49/18670 0.06258 0.2119 0.1625 BMP1/SH3GL2/ABCG1/PLTP/BIN1 5 BP GO:0001657 ureteric bud development 8/819 97/18670 0.06293 0.2124 0.1629 CRLF1/MAGED1/BMP4/FOXC1/WNT11/BCL2/CAT/SDC4 8 BP GO:0051591 response to cAMP 8/819 97/18670 0.06293 0.2124 0.1629 SPARC/COL1A1/HSPA5/LDHA/TYR/RAPGEF1/CNGA3/EZR 8 BP GO:0120162 positive regulation of cold-induced thermogenesis 8/819 97/18670 0.06293 0.2124 0.1629 GJA1/HADH/EPAS1/GRB10/UCP2/JAK2/IL4R/PER2 8 BP GO:1990868 response to chemokine 8/819 97/18670 0.06293 0.2124 0.1629 CXCL12/CCRL2/FOXC1/CIB1/LOX/CCR3/HIF1A/CCR1 8 BP GO:1990869 cellular response to chemokine 8/819 97/18670 0.06293 0.2124 0.1629 CXCL12/CCRL2/FOXC1/CIB1/LOX/CCR3/HIF1A/CCR1 8 BP GO:0005976 polysaccharide metabolic process 9/819 114/18670 0.06318 0.213 0.1634 ENPP1/NDST1/CHST7/HAS2/EXT1/IL6ST/MTOR/PGM1/PER2 9 BP GO:0042035 regulation of cytokine biosynthetic process 9/819 114/18670 0.06318 0.213 0.1634 ASB1/THBS1/INHBB/MAST2/UBE2J1/STAT3/KLF4/JAK2/ZFP36 9 BP GO:0001818 negative regulation of cytokine production 19/819 296/18670 0.06328 0.2132 0.1635 ASB1/THBS1/PIN1/ISG15/ANGPT1/ADCY7/IL12A/TRIM25/INHBB/CD2AP/CD24/TGFB2/ARRB2/KLF4/GAS6/ZFP36/SOCS5/WNT11/EZR 19 BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 11/819 149/18670 0.06371 0.2145 0.1645 PRKCA/RAMP2/FZD2/MET/NMT1/PALM/ARRB2/RGS2/PLCB1/HTR2B/PHB 11 BP GO:0014855 striated muscle cell proliferation 7/819 81/18670 0.06466 0.2172 0.1666 ANGPT1/GJA1/TGFBR1/FOXC1/STAT3/TGFB2/JAK2 7 BP GO:0034109 homotypic cell-cell adhesion 7/819 81/18670 0.06466 0.2172 0.1666 PRKCA/COMP/CLIC1/MYH9/ITGB3/PIK3CB/GAS6 7 BP GO:1903533 regulation of protein targeting 7/819 81/18670 0.06466 0.2172 0.1666 CEMIP/ITGB2/CIB1/VPS11/HAX1/ITGB1BP1/LMAN1 7 BP GO:2001021 negative regulation of response to DNA damage stimulus 7/819 81/18670 0.06466 0.2172 0.1666 THOC1/CXCL12/BCL2L1/SNAI2/PTTG1IP/TERF2/BCL2 7 BP GO:0050953 sensory perception of light stimulus 15/819 222/18670 0.06495 0.2178 0.167 CYP1B1/COL11A1/HPS1/COL1A1/GJC1/MYO5A/TYR/EFEMP1/EPAS1/ABLIM1/CNGA3/GLRB/RABGGTA/HSF4/CLIC5 15 BP GO:0070663 regulation of leukocyte proliferation 15/819 222/18670 0.06495 0.2178 0.167 GREM1/CD55/BMP4/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/PAWR/SDC4/PKN1/NCK1/HLA-DPB1 15 BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 6/819 65/18670 0.06497 0.2178 0.167 KCNN4/THY1/PRKCB/RAB29/PAWR/EZR 6 BP GO:0072329 monocarboxylic acid catabolic process 10/819 132/18670 0.06514 0.2183 0.1674 PLA2G15/ECI1/PCCB/SORD/AUH/HADH/FAH/PEX7/MTOR/ETFB 10 BP GO:0045088 regulation of innate immune response 27/819 452/18670 0.06527 0.2186 0.1676 MAPKAPK3/PSMD8/PSMB7/MICB/GRN/ADAR/PSMD1/IL12A/ITGB2/NR1H2/NR1H3/PIK3C3/POLR3D/XRCC6/PSMB6/POLR3G/ARRB2/JAK2/RSAD2/SOCS3/HEXIM1/IRF7/PTPN11/PSMD3/PSMD2/PSMB8/CREBBP 27 BP GO:0002701 negative regulation of production of molecular mediator of immune response 4/819 35/18670 0.06567 0.2189 0.1679 THOC1/ANGPT1/IL13RA2/TGFB2 4 BP GO:0035909 aorta morphogenesis 4/819 35/18670 0.06567 0.2189 0.1679 COL3A1/MYLK/TGFB2/SOX4 4 BP GO:0042092 type 2 immune response 4/819 35/18670 0.06567 0.2189 0.1679 RSAD2/SOCS5/IL4R/HLX 4 BP GO:0042462 eye photoreceptor cell development 4/819 35/18670 0.06567 0.2189 0.1679 NAGLU/NTRK2/TUG1/THY1 4 BP GO:0046131 pyrimidine ribonucleoside metabolic process 4/819 35/18670 0.06567 0.2189 0.1679 NME3/APOBEC3B/APOBEC3C/CTPS1 4 BP GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4/819 35/18670 0.06567 0.2189 0.1679 HIP1R/NMT1/BAD/BCL2 4 BP GO:1902991 regulation of amyloid precursor protein catabolic process 4/819 35/18670 0.06567 0.2189 0.1679 PIN1/ABCG1/SPON1/BIN1 4 BP GO:0002573 myeloid leukocyte differentiation 14/819 204/18670 0.06578 0.2189 0.1679 PRKCA/BMP4/PIK3R1/LBR/MYH9/RASSF2/HAX1/CCR1/TSPAN2/MTOR/IRF7/ROR2/TCIRG1/SH3PXD2A 14 BP GO:0015931 nucleobase-containing compound transport 16/819 241/18670 0.06581 0.2189 0.1679 SLC35D2/THOC1/GJA1/SLC29A1/DDX39A/NUP205/NUP93/NUP153/RRS1/TERF2/ZFP36/SEC13/CKAP5/SRSF7/AGFG1/MX2 16 BP GO:0038093 Fc receptor signaling pathway 16/819 241/18670 0.06581 0.2189 0.1679 MAPK3/PSMD8/PSMB7/PIK3R1/PSMD1/MYO10/PSMB6/ARPC1B/PIK3R2/PIK3CB/RAPGEF1/MAP2K4/PSMD3/PSMD2/PSMB8/NCK1 16 BP GO:0046660 female sex differentiation 9/819 115/18670 0.06602 0.2189 0.1679 FOXC1/NUPR1/HSPA5/BCL2L1/INHBB/ARRB2/BCL2/PTX3/FOXO3 9 BP GO:0002042 cell migration involved in sprouting angiogenesis 8/819 98/18670 0.06602 0.2189 0.1679 GREM1/THBS1/CIB1/EPHB4/NRP1/KLF4/ITGB1BP1/ITGB1 8 BP GO:0046364 monosaccharide biosynthetic process 8/819 98/18670 0.06602 0.2189 0.1679 SORD/KAT2B/FBP1/PDK2/PGM1/PER2/TPI1/MDH2 8 BP GO:0072163 mesonephric epithelium development 8/819 98/18670 0.06602 0.2189 0.1679 CRLF1/MAGED1/BMP4/FOXC1/WNT11/BCL2/CAT/SDC4 8 BP GO:0072164 mesonephric tubule development 8/819 98/18670 0.06602 0.2189 0.1679 CRLF1/MAGED1/BMP4/FOXC1/WNT11/BCL2/CAT/SDC4 8 BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 8/819 98/18670 0.06602 0.2189 0.1679 CXCL12/BCL2L1/SNAI2/HIF1A/NDUFS3/TRAP1/PTTG1IP/BCL2 8 BP GO:0051302 regulation of cell division 12/819 168/18670 0.0665 0.2204 0.169 THBS4/PIN1/KLHL21/VEGFC/BCL2L1/CIB1/PIK3C3/PDGFA/TGFB2/ITGB1BP1/HTR2B/CAT 12 BP GO:0070661 leukocyte proliferation 19/819 298/18670 0.06669 0.2206 0.1692 GREM1/CD55/CD151/BMP4/GJA1/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/TCIRG1/PAWR/SDC4/PKN1/CTPS1/NCK1/HLA-DPB1 19 BP GO:0045137 development of primary sexual characteristics 15/819 223/18670 0.06696 0.2206 0.1692 GJA1/TGFBR1/FOXC1/NUPR1/HSPA5/ADAM15/BCL2L1/INHBB/TGFB2/ARRB2/BCL2/PTX3/FOXO3/EIF2S2/TMF1 15 BP GO:0086009 membrane repolarization 5/819 50/18670 0.06714 0.2206 0.1692 GJA1/KCND3/SNTA1/CAV3/ATP1B1 5 BP GO:0071333 cellular response to glucose stimulus 10/819 133/18670 0.06782 0.2206 0.1692 NADK/OXCT1/ADCY8/HIF1A/GCLM/GAS6/UNC13B/BAD/FOXO3/SOX4 10 BP GO:0046209 nitric oxide metabolic process 7/819 82/18670 0.06816 0.2206 0.1692 CYP1B1/DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 7 BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 7/819 82/18670 0.06816 0.2206 0.1692 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/THY1/CACNA1C 7 BP GO:0097581 lamellipodium organization 7/819 82/18670 0.06816 0.2206 0.1692 TWF2/FSCN1/ABLIM1/MTOR/ENPP2/NCK1/ITGB1 7 BP GO:0051091 positive regulation of DNA-binding transcription factor activity 17/819 261/18670 0.06823 0.2206 0.1692 IL18R1/ADCY8/IL1RAP/PRKD1/ITGB2/TRIM25/CIB1/FZD2/LRRFIP1/ANXA3/DDR2/STAT3/JAK2/PRKCB/PPRC1/FZD1/CAT 17 BP GO:0070646 protein modification by small protein removal 19/819 299/18670 0.06844 0.2206 0.1692 STAM/SIAH2/USP5/PSMD8/PSMB7/RAD23A/TGFBR1/PSMD1/KAT2B/HIF1A/PSMB6/USPL1/ARRB2/USP10/COPS8/NEDD8/PSMD3/PSMD2/PSMB8 19 BP GO:0001768 establishment of T cell polarity 2/819 10/18670 0.06847 0.2206 0.1692 MYH9/GSN 2 BP GO:0002934 desmosome organization 2/819 10/18670 0.06847 0.2206 0.1692 PRKCA/SNAI2 2 BP GO:0006171 cAMP biosynthetic process 2/819 10/18670 0.06847 0.2206 0.1692 ADCY8/ADCY7 2 BP GO:0006570 tyrosine metabolic process 2/819 10/18670 0.06847 0.2206 0.1692 TYR/FAH 2 BP GO:0006971 hypotonic response 2/819 10/18670 0.06847 0.2206 0.1692 MYLK/ITGA2 2 BP GO:0007016 cytoskeletal anchoring at plasma membrane 2/819 10/18670 0.06847 0.2206 0.1692 FLNB/EZR 2 BP GO:0009396 folic acid-containing compound biosynthetic process 2/819 10/18670 0.06847 0.2206 0.1692 GART/MTHFD1 2 BP GO:0010918 positive regulation of mitochondrial membrane potential 2/819 10/18670 0.06847 0.2206 0.1692 CTNS/BAD 2 BP GO:0010944 negative regulation of transcription by competitive promoter binding 2/819 10/18670 0.06847 0.2206 0.1692 TFAP2A/PHB 2 BP GO:0014041 regulation of neuron maturation 2/819 10/18670 0.06847 0.2206 0.1692 MTOR/BCL2 2 BP GO:0021548 pons development 2/819 10/18670 0.06847 0.2206 0.1692 UQCRQ/BCL2 2 BP GO:0021562 vestibulocochlear nerve development 2/819 10/18670 0.06847 0.2206 0.1692 NRP1/NRP2 2 BP GO:0032525 somite rostral/caudal axis specification 2/819 10/18670 0.06847 0.2206 0.1692 KDM6A/TMED2 2 BP GO:0034058 endosomal vesicle fusion 2/819 10/18670 0.06847 0.2206 0.1692 VPS41/VPS11 2 BP GO:0034350 regulation of glial cell apoptotic process 2/819 10/18670 0.06847 0.2206 0.1692 PRKCA/GAS6 2 BP GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 2/819 10/18670 0.06847 0.2206 0.1692 EXOSC7/EXOSC2 2 BP GO:0035878 nail development 2/819 10/18670 0.06847 0.2206 0.1692 FZD6/ITGA6 2 BP GO:0035999 tetrahydrofolate interconversion 2/819 10/18670 0.06847 0.2206 0.1692 MTHFD2/MTHFD1 2 BP GO:0036500 ATF6-mediated unfolded protein response 2/819 10/18670 0.06847 0.2206 0.1692 HSPA5/MBTPS1 2 BP GO:0042989 sequestering of actin monomers 2/819 10/18670 0.06847 0.2206 0.1692 GSN/TWF2 2 BP GO:0045792 negative regulation of cell size 2/819 10/18670 0.06847 0.2206 0.1692 CAV3/MTOR 2 BP GO:0048340 paraxial mesoderm morphogenesis 2/819 10/18670 0.06847 0.2206 0.1692 FOXC1/WNT11 2 BP GO:0048570 notochord morphogenesis 2/819 10/18670 0.06847 0.2206 0.1692 WNT11/KDM6A 2 BP GO:0051593 response to folic acid 2/819 10/18670 0.06847 0.2206 0.1692 FOLR2/GSN 2 BP GO:0060513 prostatic bud formation 2/819 10/18670 0.06847 0.2206 0.1692 BMP4/SULF1 2 BP GO:0060600 dichotomous subdivision of an epithelial terminal unit 2/819 10/18670 0.06847 0.2206 0.1692 PLXND1/NRP1 2 BP GO:0071233 cellular response to leucine 2/819 10/18670 0.06847 0.2206 0.1692 RRAGD/MTOR 2 BP GO:0097048 dendritic cell apoptotic process 2/819 10/18670 0.06847 0.2206 0.1692 CXCL12/GAS6 2 BP GO:0098722 asymmetric stem cell division 2/819 10/18670 0.06847 0.2206 0.1692 SOX5/TEAD3 2 BP GO:1900426 positive regulation of defense response to bacterium 2/819 10/18670 0.06847 0.2206 0.1692 GRN/UNC13B 2 BP GO:1901033 positive regulation of response to reactive oxygen species 2/819 10/18670 0.06847 0.2206 0.1692 PAWR/FOXO3 2 BP GO:1903332 regulation of protein folding 2/819 10/18670 0.06847 0.2206 0.1692 GRN/HSPA5 2 BP GO:1903789 regulation of amino acid transmembrane transport 2/819 10/18670 0.06847 0.2206 0.1692 RGS2/PER2 2 BP GO:1903897 regulation of PERK-mediated unfolded protein response 2/819 10/18670 0.06847 0.2206 0.1692 HSPA5/NCK1 2 BP GO:1990253 cellular response to leucine starvation 2/819 10/18670 0.06847 0.2206 0.1692 RRAGD/MTOR 2 BP GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 2/819 10/18670 0.06847 0.2206 0.1692 SH3GL2/NTRK2 2 BP GO:2000109 regulation of macrophage apoptotic process 2/819 10/18670 0.06847 0.2206 0.1692 IRF7/CDKN2A 2 BP GO:2000668 regulation of dendritic cell apoptotic process 2/819 10/18670 0.06847 0.2206 0.1692 CXCL12/GAS6 2 BP GO:0030307 positive regulation of cell growth 12/819 169/18670 0.06888 0.2211 0.1695 PIN1/CXCL12/TGFBR1/IGFBP1/CIB1/ADNP2/NRP1/TWF2/TGFB2/EXOSC2/MTOR/BCL2 12 BP GO:0038095 Fc-epsilon receptor signaling pathway 12/819 169/18670 0.06888 0.2211 0.1695 MAPK3/PSMD8/PSMB7/PIK3R1/PSMD1/PSMB6/PIK3R2/PIK3CB/MAP2K4/PSMD3/PSMD2/PSMB8 12 BP GO:0021782 glial cell development 9/819 116/18670 0.06893 0.2211 0.1695 MYOC/GRN/NTRK2/PLP1/GSN/TSPAN2/LPAR1/ROR2/SOX4 9 BP GO:0006687 glycosphingolipid metabolic process 6/819 66/18670 0.06894 0.2211 0.1695 ST3GAL5/CTSA/CLN3/ESYT1/GM2A/ASAH1 6 BP GO:0040014 regulation of multicellular organism growth 6/819 66/18670 0.06894 0.2211 0.1695 STC2/GHR/PPIB/STAT3/BCL2/EZR 6 BP GO:0045428 regulation of nitric oxide biosynthetic process 6/819 66/18670 0.06894 0.2211 0.1695 DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 6 BP GO:0051926 negative regulation of calcium ion transport 6/819 66/18670 0.06894 0.2211 0.1695 GSTO1/CLIC2/GNB5/CAV3/BCL2/BIN1 6 BP GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 6/819 66/18670 0.06894 0.2211 0.1695 GPC4/ITGB3/EPS8/RAB8A/AP2B1/FRRS1L 6 BP GO:0022412 cellular process involved in reproduction in multicellular organism 22/819 357/18670 0.06907 0.2213 0.1697 BMP4/FOLR3/FOLR2/TGFBR1/FOXC1/BCL2L1/CIB1/HSPA2/INHBB/ETV6/DEFB1/MAST2/UBE2J1/ARRB2/MTOR/BCL2/PPP2R1A/PTX3/FOXO3/AGFG1/TMF1/ITGB1 22 BP GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3/819 22/18670 0.06969 0.2215 0.1699 EXOSC7/RRS1/EXOSC2 3 BP GO:0006925 inflammatory cell apoptotic process 3/819 22/18670 0.06969 0.2215 0.1699 PIK3CB/IRF7/CDKN2A 3 BP GO:0021854 hypothalamus development 3/819 22/18670 0.06969 0.2215 0.1699 NRP1/UQCRQ/NRP2 3 BP GO:0032469 endoplasmic reticulum calcium ion homeostasis 3/819 22/18670 0.06969 0.2215 0.1699 ATP2A2/TGM2/BCL2 3 BP GO:0033622 integrin activation 3/819 22/18670 0.06969 0.2215 0.1699 COL16A1/CXCL12/ITGB1BP1 3 BP GO:0034311 diol metabolic process 3/819 22/18670 0.06969 0.2215 0.1699 PCBD1/QDPR/ASAH1 3 BP GO:0042094 interleukin-2 biosynthetic process 3/819 22/18670 0.06969 0.2215 0.1699 IL1RAP/ZFP36/PAWR 3 BP GO:0043496 regulation of protein homodimerization activity 3/819 22/18670 0.06969 0.2215 0.1699 PCBD1/HSPA5/BCL2 3 BP GO:0045624 positive regulation of T-helper cell differentiation 3/819 22/18670 0.06969 0.2215 0.1699 SOCS5/IL4R/HLX 3 BP GO:0045723 positive regulation of fatty acid biosynthetic process 3/819 22/18670 0.06969 0.2215 0.1699 LPGAT1/NR1H2/NR1H3 3 BP GO:0046058 cAMP metabolic process 3/819 22/18670 0.06969 0.2215 0.1699 ADCY8/ADCY7/PDE4B 3 BP GO:0051000 positive regulation of nitric-oxide synthase activity 3/819 22/18670 0.06969 0.2215 0.1699 HIF1A/TERF2/HTR2B 3 BP GO:0051457 maintenance of protein location in nucleus 3/819 22/18670 0.06969 0.2215 0.1699 RANGAP1/TXN/ARL2 3 BP GO:0071404 cellular response to low-density lipoprotein particle stimulus 3/819 22/18670 0.06969 0.2215 0.1699 ITGB2/SOCS5/ITGB1 3 BP GO:0048565 digestive tract development 10/819 134/18670 0.07056 0.2241 0.1719 COL3A1/PCSK5/RARRES2/BMP4/HIF1A/TGFB2/ITGA6/WNT11/BCL2/HLX 10 BP GO:0031345 negative regulation of cell projection organization 13/819 188/18670 0.07087 0.2248 0.1724 TRAK2/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/ITGA3/THY1/PMP22/GRIN2B/LPAR1/RAB29/TRPC6 13 BP GO:0030902 hindbrain development 11/819 152/18670 0.07127 0.2248 0.1724 NAGLU/FOXC1/B4GALT2/HSPA5/CKB/GART/UQCRQ/LPAR1/BCL2/PTPN11/ITGB1 11 BP GO:0007051 spindle organization 12/819 170/18670 0.07132 0.2248 0.1724 ESPL1/HAUS7/TBCE/TACC2/MYH9/MAPRE3/NEK7/CHMP2A/PPP2R1A/CKAP5/EML1/EZR 12 BP GO:0003417 growth plate cartilage development 4/819 36/18670 0.07143 0.2248 0.1724 COMP/COL14A1/COL6A3/COL7A1 4 BP GO:0010573 vascular endothelial growth factor production 4/819 36/18670 0.07143 0.2248 0.1724 CYP1B1/HIF1A/SULF1/IL6ST 4 BP GO:0010742 macrophage derived foam cell differentiation 4/819 36/18670 0.07143 0.2248 0.1724 ABCG1/NR1H2/NR1H3/ITGB3 4 BP GO:0034390 smooth muscle cell apoptotic process 4/819 36/18670 0.07143 0.2248 0.1724 IL12A/ARRB2/MAP2K4/CDKN2A 4 BP GO:0034391 regulation of smooth muscle cell apoptotic process 4/819 36/18670 0.07143 0.2248 0.1724 IL12A/ARRB2/MAP2K4/CDKN2A 4 BP GO:0050931 pigment cell differentiation 4/819 36/18670 0.07143 0.2248 0.1724 ENPP1/RAB32/MYO5A/BCL2 4 BP GO:0051031 tRNA transport 4/819 36/18670 0.07143 0.2248 0.1724 NUP205/NUP93/NUP153/SEC13 4 BP GO:0090077 foam cell differentiation 4/819 36/18670 0.07143 0.2248 0.1724 ABCG1/NR1H2/NR1H3/ITGB3 4 BP GO:0090313 regulation of protein targeting to membrane 4/819 36/18670 0.07143 0.2248 0.1724 CEMIP/ITGB2/CIB1/ITGB1BP1 4 BP GO:1901099 negative regulation of signal transduction in absence of ligand 4/819 36/18670 0.07143 0.2248 0.1724 UNC5B/BCL2L1/SNAI2/BCL2 4 BP GO:2000310 regulation of NMDA receptor activity 4/819 36/18670 0.07143 0.2248 0.1724 EPHB2/ANXA3/GRIN2B/GRIN2A 4 BP GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 4/819 36/18670 0.07143 0.2248 0.1724 CD55/SOCS5/IL4R/HLX 4 BP GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 4/819 36/18670 0.07143 0.2248 0.1724 UNC5B/BCL2L1/SNAI2/BCL2 4 BP GO:2000106 regulation of leukocyte apoptotic process 7/819 83/18670 0.07177 0.2257 0.1731 CXCL12/BMP4/HIF1A/PIK3CB/GAS6/IRF7/CDKN2A 7 BP GO:0006213 pyrimidine nucleoside metabolic process 5/819 51/18670 0.07188 0.2257 0.1731 NME3/APOBEC3B/TK2/APOBEC3C/CTPS1 5 BP GO:0048260 positive regulation of receptor-mediated endocytosis 5/819 51/18670 0.07188 0.2257 0.1731 SFRP4/GREM1/HIP1R/ANGPT1/ARRB2 5 BP GO:0050999 regulation of nitric-oxide synthase activity 5/819 51/18670 0.07188 0.2257 0.1731 DDAH2/HIF1A/CAV3/TERF2/HTR2B 5 BP GO:0043666 regulation of phosphoprotein phosphatase activity 9/819 117/18670 0.07193 0.2257 0.1731 PPP1R7/ITGA1/ANKLE2/JAK2/MTOR/ENSA/PPP2R1A/PPP2R5D/PHACTR4 9 BP GO:0090174 organelle membrane fusion 8/819 100/18670 0.07249 0.2273 0.1744 VPS41/TBC1D4/VPS11/GOSR2/SPG11/RAB8A/TAP1/VAMP3 8 BP GO:0071331 cellular response to hexose stimulus 10/819 135/18670 0.07337 0.23 0.1764 NADK/OXCT1/ADCY8/HIF1A/GCLM/GAS6/UNC13B/BAD/FOXO3/SOX4 10 BP GO:0006937 regulation of muscle contraction 12/819 171/18670 0.0738 0.2312 0.1773 GSTO1/CLIC2/ATP2A2/TPM1/PDE4B/CAV3/ATP1B1/RGS2/CACNA1C/CNN1/ITGA2/BIN1 12 BP GO:0042133 neurotransmitter metabolic process 11/819 153/18670 0.07391 0.2314 0.1775 CYP1B1/CLN3/DDAH2/ITGB2/GART/KLF4/JAK2/MTOR/PTX3/ALDH7A1/GRIN2A 11 BP GO:0050670 regulation of lymphocyte proliferation 14/819 208/18670 0.07455 0.2332 0.1789 CD55/BMP4/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/PAWR/SDC4/PKN1/NCK1/HLA-DPB1 14 BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 7/819 84/18670 0.07549 0.2359 0.1809 CRYAB/SIAH2/THBS1/LAMTOR5/ARRB2/KLF4/GAS6 7 BP GO:0045445 myoblast differentiation 7/819 84/18670 0.07549 0.2359 0.1809 GREM1/TCF7L2/BMP4/MAML1/MAP3K5/EPAS1/PLCB1 7 BP GO:0031331 positive regulation of cellular catabolic process 22/819 361/18670 0.07576 0.2366 0.1815 MAPK3/CTSC/USP5/RAD23A/ABHD5/PRKD1/NUPR1/RNF144A/VPS11/TNRC6B/HIF1A/CLEC16A/PIK3CB/CAV3/PNPLA2/PTTG1IP/ZFP36/SOCS5/BAD/FOXO3/RCHY1/EZR 22 BP GO:0046632 alpha-beta T cell differentiation 8/819 101/18670 0.07587 0.2368 0.1816 IL18R1/STAT3/RSAD2/SOCS5/IL4R/MTOR/BCL2/HLX 8 BP GO:0071326 cellular response to monosaccharide stimulus 10/819 136/18670 0.07626 0.2379 0.1825 NADK/OXCT1/ADCY8/HIF1A/GCLM/GAS6/UNC13B/BAD/FOXO3/SOX4 10 BP GO:2000772 regulation of cellular senescence 5/819 52/18670 0.07681 0.2388 0.1831 ARNTL/TERF2/PAWR/HMGA1/CDKN2A 5 BP GO:0032944 regulation of mononuclear cell proliferation 14/819 209/18670 0.07685 0.2388 0.1831 CD55/BMP4/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/PAWR/SDC4/PKN1/NCK1/HLA-DPB1 14 BP GO:0035303 regulation of dephosphorylation 14/819 209/18670 0.07685 0.2388 0.1831 PPP1R7/PIN1/ITGA1/IQGAP1/ANKLE2/TGFB2/JAK2/MTOR/ENSA/PPP2R1A/CSRNP2/ITGA2/PPP2R5D/PHACTR4 14 BP GO:0002292 T cell differentiation involved in immune response 6/819 68/18670 0.07732 0.2388 0.1831 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:0030201 heparan sulfate proteoglycan metabolic process 4/819 37/18670 0.07744 0.2388 0.1831 NDST1/TCF7L2/SULF1/EXT1 4 BP GO:0032941 secretion by tissue 4/819 37/18670 0.07744 0.2388 0.1831 GJA1/NR1H3/KCNN4/P2RY2 4 BP GO:0051084 'de novo' posttranslational protein folding 4/819 37/18670 0.07744 0.2388 0.1831 HSPA5/HSPA2/DNAJB5/BAG1 4 BP GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 4/819 37/18670 0.07744 0.2388 0.1831 MYOC/CIB1/NRP1/HAS2 4 BP GO:1903432 regulation of TORC1 signaling 4/819 37/18670 0.07744 0.2388 0.1831 RRAGD/LAMTOR5/CLEC16A/SEC13 4 BP GO:1904358 positive regulation of telomere maintenance via telomere lengthening 4/819 37/18670 0.07744 0.2388 0.1831 MAPK3/MAP3K4/NEK7/CCT7 4 BP GO:2000249 regulation of actin cytoskeleton reorganization 4/819 37/18670 0.07744 0.2388 0.1831 NRP1/HAX1/CD2AP/GMFG 4 BP GO:0006297 nucleotide-excision repair, DNA gap filling 3/819 23/18670 0.07764 0.2388 0.1831 RFC3/RPA3/POLD2 3 BP GO:0009068 aspartate family amino acid catabolic process 3/819 23/18670 0.07764 0.2388 0.1831 OGDH/ALDH7A1/CRYM 3 BP GO:0032799 low-density lipoprotein receptor particle metabolic process 3/819 23/18670 0.07764 0.2388 0.1831 ITGB3/AP2B1/VLDLR 3 BP GO:0051589 negative regulation of neurotransmitter transport 3/819 23/18670 0.07764 0.2388 0.1831 GPM6B/RGS2/ASIC1 3 BP GO:0051882 mitochondrial depolarization 3/819 23/18670 0.07764 0.2388 0.1831 MYOC/GCLM/BCL2 3 BP GO:0060055 angiogenesis involved in wound healing 3/819 23/18670 0.07764 0.2388 0.1831 PRCP/ITGB3/PIK3CB 3 BP GO:0071305 cellular response to vitamin D 3/819 23/18670 0.07764 0.2388 0.1831 VDR/SNAI2/TNC 3 BP GO:0072215 regulation of metanephros development 3/819 23/18670 0.07764 0.2388 0.1831 BMP4/WWTR1/PDGFA 3 BP GO:0072337 modified amino acid transport 3/819 23/18670 0.07764 0.2388 0.1831 CTNS/FOLR3/FOLR2 3 BP GO:0089718 amino acid import across plasma membrane 3/819 23/18670 0.07764 0.2388 0.1831 SLC1A5/RGS2/PER2 3 BP GO:0090343 positive regulation of cell aging 3/819 23/18670 0.07764 0.2388 0.1831 PAWR/HMGA1/CDKN2A 3 BP GO:1903429 regulation of cell maturation 3/819 23/18670 0.07764 0.2388 0.1831 MTOR/BCL2/PPP2R1A 3 BP GO:2000637 positive regulation of gene silencing by miRNA 3/819 23/18670 0.07764 0.2388 0.1831 BMP4/STAT3/ZFP36 3 BP GO:2000726 negative regulation of cardiac muscle cell differentiation 3/819 23/18670 0.07764 0.2388 0.1831 FZD7/CAV3/RGS2 3 BP GO:1903362 regulation of cellular protein catabolic process 16/819 247/18670 0.07803 0.2398 0.1839 CTSC/USP5/RAD23A/NUPR1/RNF144A/VPS11/CLEC16A/UBE2J1/CAV3/PTTG1IP/SOCS5/MAP1A/RYBP/RCHY1/EZR/TMF1 16 BP GO:0071478 cellular response to radiation 13/819 191/18670 0.07806 0.2398 0.1839 ADIRF/CRYAB/PIK3R1/HSPA5/BCL2L1/POLE3/SNAI2/XRCC6/PTPRK/NMT1/CASP9/XPC/CREBBP 13 BP GO:0010469 regulation of signaling receptor activity 12/819 173/18670 0.07895 0.2424 0.1859 GREM1/EPHB2/NPTX2/NRP1/ANXA3/CAV3/NPTX1/GRIN2B/SOCS5/TSG101/GRIN2A/ITGB1 12 BP GO:0045862 positive regulation of proteolysis 22/819 363/18670 0.07926 0.2428 0.1862 MAPK3/CTSC/HIP1R/USP5/RAD23A/GRN/NUPR1/MYH9/RNF144A/MAP3K5/GSN/CAV3/STAT3/JAK2/GRIN2B/SOCS5/SPON1/BAD/PHB/CASP9/RCHY1/GRIN2A 22 BP GO:2001057 reactive nitrogen species metabolic process 7/819 85/18670 0.07932 0.2428 0.1862 CYP1B1/DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 7 BP GO:0001823 mesonephros development 8/819 102/18670 0.07933 0.2428 0.1862 CRLF1/MAGED1/BMP4/FOXC1/WNT11/BCL2/CAT/SDC4 8 BP GO:0010522 regulation of calcium ion transport into cytosol 8/819 102/18670 0.07933 0.2428 0.1862 GSTO1/CLIC2/CEMIP/MYO5A/DIAPH1/THY1/BCL2/CACNA1C 8 BP GO:2000379 positive regulation of reactive oxygen species metabolic process 8/819 102/18670 0.07933 0.2428 0.1862 THBS1/DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3/FOXO3 8 BP GO:0010977 negative regulation of neuron projection development 11/819 155/18670 0.07939 0.2428 0.1862 TRAK2/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/THY1/PMP22/LPAR1/RAB29/TRPC6 11 BP GO:1902652 secondary alcohol metabolic process 11/819 155/18670 0.07939 0.2428 0.1862 TM7SF2/ABCG1/FDXR/LBR/CYP3A4/CYP27A1/SULT2B1/MBTPS1/CAT/VLDLR/NFYB 11 BP GO:0010721 negative regulation of cell development 21/819 344/18670 0.08014 0.244 0.1872 COL3A1/IDH2/TRAK2/POSTN/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/CAV3/THY1/STAT3/NOTCH3/PMP22/ITGB1BP1/RGS2/LPAR1/RAB29/BCL2/TRPC6/FOXO3 21 BP GO:1901988 negative regulation of cell cycle phase transition 17/819 267/18670 0.08023 0.244 0.1872 NACC2/PSMD8/PSMB7/PSMD1/PSMB6/PRMT1/KLF4/SYF2/BCL2/ANAPC15/PSMD3/SOX4/IK/CTDSP2/PSMD2/PSMB8/CDKN2A 17 BP GO:0001778 plasma membrane repair 2/819 11/18670 0.08131 0.244 0.1872 MYH9/CAV3 2 BP GO:0002638 negative regulation of immunoglobulin production 2/819 11/18670 0.08131 0.244 0.1872 THOC1/IL13RA2 2 BP GO:0002887 negative regulation of myeloid leukocyte mediated immunity 2/819 11/18670 0.08131 0.244 0.1872 ABR/IL13RA2 2 BP GO:0003093 regulation of glomerular filtration 2/819 11/18670 0.08131 0.244 0.1872 GJA1/GAS6 2 BP GO:0006048 UDP-N-acetylglucosamine biosynthetic process 2/819 11/18670 0.08131 0.244 0.1872 RENBP/GNPDA1 2 BP GO:0009113 purine nucleobase biosynthetic process 2/819 11/18670 0.08131 0.244 0.1872 GART/MTHFD1 2 BP GO:0014820 tonic smooth muscle contraction 2/819 11/18670 0.08131 0.244 0.1872 MYLK/EDNRA 2 BP GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 2/819 11/18670 0.08131 0.244 0.1872 NDST1/EXT1 2 BP GO:0016264 gap junction assembly 2/819 11/18670 0.08131 0.244 0.1872 GJA1/GJC1 2 BP GO:0021604 cranial nerve structural organization 2/819 11/18670 0.08131 0.244 0.1872 NRP1/NRP2 2 BP GO:0031915 positive regulation of synaptic plasticity 2/819 11/18670 0.08131 0.244 0.1872 ADCY8/EPHB2 2 BP GO:0032908 regulation of transforming growth factor beta1 production 2/819 11/18670 0.08131 0.244 0.1872 THBS1/CD2AP 2 BP GO:0035542 regulation of SNARE complex assembly 2/819 11/18670 0.08131 0.244 0.1872 VPS41/VPS11 2 BP GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 2/819 11/18670 0.08131 0.244 0.1872 HIF1A/EPAS1 2 BP GO:0045176 apical protein localization 2/819 11/18670 0.08131 0.244 0.1872 ARF4/NAPA 2 BP GO:0046348 amino sugar catabolic process 2/819 11/18670 0.08131 0.244 0.1872 RENBP/GNPDA1 2 BP GO:0046950 cellular ketone body metabolic process 2/819 11/18670 0.08131 0.244 0.1872 OXCT1/HMGCL 2 BP GO:0048548 regulation of pinocytosis 2/819 11/18670 0.08131 0.244 0.1872 NR1H2/NR1H3 2 BP GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 2/819 11/18670 0.08131 0.244 0.1872 GSTO1/CLIC2 2 BP GO:0060439 trachea morphogenesis 2/819 11/18670 0.08131 0.244 0.1872 MAPK3/BMP4 2 BP GO:0061307 cardiac neural crest cell differentiation involved in heart development 2/819 11/18670 0.08131 0.244 0.1872 MAPK3/BMP4 2 BP GO:0061308 cardiac neural crest cell development involved in heart development 2/819 11/18670 0.08131 0.244 0.1872 MAPK3/BMP4 2 BP GO:0072584 caveolin-mediated endocytosis 2/819 11/18670 0.08131 0.244 0.1872 MAPK3/CAV3 2 BP GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 2/819 11/18670 0.08131 0.244 0.1872 HSPA5/NCK1 2 BP GO:1900115 extracellular regulation of signal transduction 2/819 11/18670 0.08131 0.244 0.1872 LTBP1/FBN2 2 BP GO:1900116 extracellular negative regulation of signal transduction 2/819 11/18670 0.08131 0.244 0.1872 LTBP1/FBN2 2 BP GO:1901201 regulation of extracellular matrix assembly 2/819 11/18670 0.08131 0.244 0.1872 EMILIN1/HAS2 2 BP GO:1902946 protein localization to early endosome 2/819 11/18670 0.08131 0.244 0.1872 NRP1/EZR 2 BP GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 2/819 11/18670 0.08131 0.244 0.1872 CXCL12/KLF4 2 BP GO:1905245 regulation of aspartic-type peptidase activity 2/819 11/18670 0.08131 0.244 0.1872 GRN/BIN1 2 BP GO:2000767 positive regulation of cytoplasmic translation 2/819 11/18670 0.08131 0.244 0.1872 MTOR/NCK1 2 BP GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/819 11/18670 0.08131 0.244 0.1872 GSN/JAK2 2 BP GO:0008088 axo-dendritic transport 6/819 69/18670 0.08171 0.2449 0.1879 TRAK2/RAB27B/HIF1A/SPG11/TERF2/MAP1A 6 BP GO:0042698 ovulation cycle 6/819 69/18670 0.08171 0.2449 0.1879 HSPA5/HAS2/TGFB2/ARRB2/PTX3/FOXO3 6 BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 5/819 53/18670 0.0819 0.245 0.1879 MET/PALM/ARRB2/RGS2/HTR2B 5 BP GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 5/819 53/18670 0.0819 0.245 0.1879 THY1/SOCS5/SOCS3/TSG101/PPP2R1A 5 BP GO:1901185 negative regulation of ERBB signaling pathway 5/819 53/18670 0.0819 0.245 0.1879 STAM/SH3GL2/ITGA1/SOCS5/TSG101 5 BP GO:1905517 macrophage migration 5/819 53/18670 0.0819 0.245 0.1879 MAPK3/RARRES2/THBS1/EMILIN1/ROR2 5 BP GO:0042129 regulation of T cell proliferation 11/819 156/18670 0.08221 0.2455 0.1883 CD55/BMP4/CD70/IL12A/TNFRSF14/CD24/IL6ST/PAWR/SDC4/NCK1/HLA-DPB1 11 BP GO:0043535 regulation of blood vessel endothelial cell migration 11/819 156/18670 0.08221 0.2455 0.1883 PRCP/THBS1/PRKCA/ANGPT1/VEGFC/PRKD1/CIB1/NRP1/HIF1A/KLF4/ITGB1BP1 11 BP GO:0045216 cell-cell junction organization 11/819 156/18670 0.08221 0.2455 0.1883 CDH11/PRKCA/RAMP2/GJA1/TGFBR1/GJC1/SNAI2/FSCN1/ARL2/TGFB2/WNT11 11 BP GO:0022898 regulation of transmembrane transporter activity 17/819 268/18670 0.08235 0.2458 0.1885 GSTO1/CLIC2/EPHB2/GJA1/HSPA2/MYO5A/PDE4B/GNB5/ANXA3/CAV3/ATP1B1/STAC/GRIN2B/GPD1L/BCL2/TRPC6/GRIN2A 17 BP GO:0044264 cellular polysaccharide metabolic process 8/819 103/18670 0.08289 0.2473 0.1896 ENPP1/NDST1/HAS2/EXT1/IL6ST/MTOR/PGM1/PER2 8 BP GO:1901990 regulation of mitotic cell cycle phase transition 26/819 444/18670 0.08306 0.2475 0.1898 ESPL1/NACC2/PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/CCND2/PSMB6/PRMT1/KLF4/SYF2/BCL2/UBE2E1/PLCB1/PPP2R1A/ANAPC15/PSMD3/CKAP5/SOX4/IK/CTDSP2/PSMD2/PSMB8/CDKN2A/XPC 26 BP GO:0050657 nucleic acid transport 13/819 193/18670 0.0831 0.2475 0.1898 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/TERF2/ZFP36/SEC13/CKAP5/SRSF7/AGFG1/MX2 13 BP GO:0050658 RNA transport 13/819 193/18670 0.0831 0.2475 0.1898 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/TERF2/ZFP36/SEC13/CKAP5/SRSF7/AGFG1/MX2 13 BP GO:0001776 leukocyte homeostasis 7/819 86/18670 0.08326 0.2475 0.1898 PDE4B/HIF1A/PIK3CB/TNFRSF17/BCL2/TCIRG1/PKN1 7 BP GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 7/819 86/18670 0.08326 0.2475 0.1898 KDELR3/ARF4/NAPA/ARFGAP2/KIF2C/COG4/TMED2 7 BP GO:0042058 regulation of epidermal growth factor receptor signaling pathway 7/819 86/18670 0.08326 0.2475 0.1898 STAM/HIP1R/DOK1/SH3GL2/ITGA1/SOCS5/TSG101 7 BP GO:0015804 neutral amino acid transport 4/819 38/18670 0.0837 0.2476 0.1899 CTNS/SLC7A8/SLC1A5/RGS2 4 BP GO:0032350 regulation of hormone metabolic process 4/819 38/18670 0.0837 0.2476 0.1899 VDR/STC2/TCF7L2/HIF1A 4 BP GO:0045022 early endosome to late endosome transport 4/819 38/18670 0.0837 0.2476 0.1899 MAPK3/PIK3C3/VPS11/EZR 4 BP GO:0046636 negative regulation of alpha-beta T cell activation 4/819 38/18670 0.0837 0.2476 0.1899 TNFRSF14/SOCS5/IL4R/HLX 4 BP GO:0060416 response to growth hormone 4/819 38/18670 0.0837 0.2476 0.1899 PIK3R1/GHR/STAT3/JAK2 4 BP GO:0097064 ncRNA export from nucleus 4/819 38/18670 0.0837 0.2476 0.1899 NUP205/NUP93/NUP153/SEC13 4 BP GO:0097352 autophagosome maturation 4/819 38/18670 0.0837 0.2476 0.1899 CLN3/CLEC16A/TSG101/MAP1LC3B 4 BP GO:1901021 positive regulation of calcium ion transmembrane transporter activity 4/819 38/18670 0.0837 0.2476 0.1899 GSTO1/HSPA2/ATP1B1/STAC 4 BP GO:1902742 apoptotic process involved in development 4/819 38/18670 0.0837 0.2476 0.1899 VDR/CRYAB/FOXC1/TGFB2 4 BP GO:0098656 anion transmembrane transport 18/819 288/18670 0.08414 0.2488 0.1908 SLC35D2/SLC7A8/CLIC2/SLC4A4/THBS1/SLC20A1/CLIC1/FOLR2/CLDN4/SLC1A5/SLC4A3/CLCN7/RGS2/GLRB/MTOR/CLCN6/PER2/CLIC5 18 BP GO:0010921 regulation of phosphatase activity 12/819 175/18670 0.08431 0.249 0.191 PPP1R7/ITGA1/ANKLE2/TGFB2/JAK2/MTOR/ENSA/PPP2R1A/CSRNP2/ITGA2/PPP2R5D/PHACTR4 12 BP GO:0046165 alcohol biosynthetic process 12/819 175/18670 0.08431 0.249 0.191 VDR/TM7SF2/PCBD1/ABCG1/LBR/QDPR/CYP3A4/CYP27A1/ASAH1/PLCB1/MBTPS1/NFYB 12 BP GO:0002700 regulation of production of molecular mediator of immune response 10/819 139/18670 0.08532 0.2513 0.1927 MAPK3/THOC1/IL18R1/ANGPT1/TNFRSF14/IL13RA2/TGFB2/RSAD2/IL4R/PKN1 10 BP GO:0031333 negative regulation of protein complex assembly 10/819 139/18670 0.08532 0.2513 0.1927 HIP1R/CRYAB/TMOD1/CAPZA2/FKBP4/GSN/TWF2/EPS8/SPTBN1/LMOD1 10 BP GO:0035304 regulation of protein dephosphorylation 10/819 139/18670 0.08532 0.2513 0.1927 PPP1R7/PIN1/ITGA1/ANKLE2/JAK2/MTOR/ENSA/PPP2R1A/PPP2R5D/PHACTR4 10 BP GO:0051588 regulation of neurotransmitter transport 10/819 139/18670 0.08532 0.2513 0.1927 ATP2A2/SV2A/ITGB3/NAPA/GPM6B/RGS2/PRKCB/UNC13B/ASIC1/PER2 10 BP GO:0002407 dendritic cell chemotaxis 3/819 24/18670 0.08596 0.2513 0.1927 IL12A/CCR1/GAS6 3 BP GO:0003272 endocardial cushion formation 3/819 24/18670 0.08596 0.2513 0.1927 TGFBR1/SNAI2/TGFB2 3 BP GO:0003418 growth plate cartilage chondrocyte differentiation 3/819 24/18670 0.08596 0.2513 0.1927 COL14A1/COL6A3/COL7A1 3 BP GO:0010288 response to lead ion 3/819 24/18670 0.08596 0.2513 0.1927 SPARC/QDPR/CAT 3 BP GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 3/819 24/18670 0.08596 0.2513 0.1927 GSTO1/CLIC2/CACNA1C 3 BP GO:0014850 response to muscle activity 3/819 24/18670 0.08596 0.2513 0.1927 POSTN/HIF1A/ITGA2 3 BP GO:0034505 tooth mineralization 3/819 24/18670 0.08596 0.2513 0.1927 COL1A1/TFAP2A/TCIRG1 3 BP GO:0042832 defense response to protozoan 3/819 24/18670 0.08596 0.2513 0.1927 IL12A/LYST/IL4R 3 BP GO:0046475 glycerophospholipid catabolic process 3/819 24/18670 0.08596 0.2513 0.1927 PLA2G15/PLA2G4C/ENPP2 3 BP GO:0046639 negative regulation of alpha-beta T cell differentiation 3/819 24/18670 0.08596 0.2513 0.1927 SOCS5/IL4R/HLX 3 BP GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 3/819 24/18670 0.08596 0.2513 0.1927 ENPP1/SULT1C2/SULT2B1 3 BP GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 3/819 24/18670 0.08596 0.2513 0.1927 KCNN4/PRKCB/RAB29 3 BP GO:0060148 positive regulation of posttranscriptional gene silencing 3/819 24/18670 0.08596 0.2513 0.1927 BMP4/STAT3/ZFP36 3 BP GO:1903020 positive regulation of glycoprotein metabolic process 3/819 24/18670 0.08596 0.2513 0.1927 TCF7L2/PLCB1/PAWR 3 BP GO:2001026 regulation of endothelial cell chemotaxis 3/819 24/18670 0.08596 0.2513 0.1927 THBS1/PRKD1/MET 3 BP GO:0007004 telomere maintenance via telomerase 6/819 70/18670 0.08624 0.2519 0.1932 MAPK3/MAP3K4/NEK7/TERF2/NHP2/CCT7 6 BP GO:0010517 regulation of phospholipase activity 6/819 70/18670 0.08624 0.2519 0.1932 NTRK2/ARF4/RGS2/LPAR1/HTR2B/EDNRA 6 BP GO:0045927 positive regulation of growth 17/819 270/18670 0.08672 0.2531 0.1941 PIN1/CXCL12/TGFBR1/IGFBP1/CIB1/ADNP2/GHR/NRP1/TWF2/PPIB/TGFB2/EXOSC2/MTOR/BCL2/PLCB1/EZR/HLX 17 BP GO:0032210 regulation of telomere maintenance via telomerase 5/819 54/18670 0.08718 0.2543 0.195 MAPK3/MAP3K4/NEK7/TERF2/CCT7 5 BP GO:0051781 positive regulation of cell division 7/819 87/18670 0.08731 0.2546 0.1952 THBS4/VEGFC/PDGFA/TGFB2/ITGB1BP1/HTR2B/CAT 7 BP GO:1903578 regulation of ATP metabolic process 9/819 122/18670 0.0881 0.2567 0.1969 NUPR1/FBP1/HIF1A/NUP205/NUP93/NUP153/STAT3/SEC13/COX7A2 9 BP GO:0010661 positive regulation of muscle cell apoptotic process 4/819 39/18670 0.09019 0.2619 0.2008 IL12A/MAP3K5/MAP2K4/CDKN2A 4 BP GO:0010874 regulation of cholesterol efflux 4/819 39/18670 0.09019 0.2619 0.2008 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0042769 DNA damage response, detection of DNA damage 4/819 39/18670 0.09019 0.2619 0.2008 RFC3/RPA3/SOX4/POLD2 4 BP GO:0060969 negative regulation of gene silencing 4/819 39/18670 0.09019 0.2619 0.2008 PHF2/ADAR/ASF1A/HMGA1 4 BP GO:1902116 negative regulation of organelle assembly 4/819 39/18670 0.09019 0.2619 0.2008 NUPR1/KAT2B/CAV3/CHMP2A 4 BP GO:1905521 regulation of macrophage migration 4/819 39/18670 0.09019 0.2619 0.2008 MAPK3/RARRES2/THBS1/EMILIN1 4 BP GO:2000826 regulation of heart morphogenesis 4/819 39/18670 0.09019 0.2619 0.2008 BMP4/TGFBR1/FOXC1/TGFB2 4 BP GO:0006641 triglyceride metabolic process 8/819 105/18670 0.09029 0.2619 0.2008 SEL1L/ABHD5/NR1H2/NR1H3/CAV3/PNPLA2/CAT/PTPN11 8 BP GO:1902750 negative regulation of cell cycle G2/M phase transition 8/819 105/18670 0.09029 0.2619 0.2008 PSMD8/PSMB7/PSMD1/PSMB6/SYF2/PSMD3/PSMD2/PSMB8 8 BP GO:0071479 cellular response to ionizing radiation 6/819 71/18670 0.0909 0.2633 0.202 CRYAB/HSPA5/BCL2L1/POLE3/SNAI2/XRCC6 6 BP GO:1904427 positive regulation of calcium ion transmembrane transport 6/819 71/18670 0.0909 0.2633 0.202 GSTO1/CEMIP/HSPA2/THY1/ATP1B1/STAC 6 BP GO:0051236 establishment of RNA localization 13/819 196/18670 0.09103 0.2636 0.2022 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/TERF2/ZFP36/SEC13/CKAP5/SRSF7/AGFG1/MX2 13 BP GO:0046651 lymphocyte proliferation 17/819 272/18670 0.09122 0.2638 0.2023 CD55/CD151/BMP4/GJA1/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/PAWR/SDC4/PKN1/CTPS1/NCK1/HLA-DPB1 17 BP GO:0070098 chemokine-mediated signaling pathway 7/819 88/18670 0.09147 0.2638 0.2023 CXCL12/CCRL2/FOXC1/CIB1/CCR3/HIF1A/CCR1 7 BP GO:1902476 chloride transmembrane transport 7/819 88/18670 0.09147 0.2638 0.2023 CLIC2/CLIC1/CLDN4/CLCN7/GLRB/CLCN6/CLIC5 7 BP GO:0097530 granulocyte migration 10/819 141/18670 0.09171 0.2638 0.2023 MAPK3/RARRES2/THBS4/THBS1/ITGA1/SCG2/ITGB2/PDE4B/BST1/TGFB2 10 BP GO:0048588 developmental cell growth 15/819 234/18670 0.09181 0.2638 0.2023 SH3GL2/PIN1/CXCL12/POSTN/IQGAP1/NRP1/SPG11/TWF2/CAV3/RGS2/MTOR/MAP2K4/NRP2/ITGB1/SORBS2 15 BP GO:0002886 regulation of myeloid leukocyte mediated immunity 5/819 55/18670 0.09262 0.2638 0.2023 ITGB2/ABR/IL13RA2/IL4R/DNASE1L3 5 BP GO:0003229 ventricular cardiac muscle tissue development 5/819 55/18670 0.09262 0.2638 0.2023 COL11A1/TGFBR1/FOXC1/TPM1/TGFB2 5 BP GO:0010823 negative regulation of mitochondrion organization 5/819 55/18670 0.09262 0.2638 0.2023 BCL2L1/CLEC16A/VAT1/ARRB2/LMAN1 5 BP GO:0043030 regulation of macrophage activation 5/819 55/18670 0.09262 0.2638 0.2023 CTSC/THBS1/GRN/NR1H3/IL4R 5 BP GO:0043113 receptor clustering 5/819 55/18670 0.09262 0.2638 0.2023 ITGB2/GSN/THY1/ITGB1BP1/GLRB 5 BP GO:0044380 protein localization to cytoskeleton 5/819 55/18670 0.09262 0.2638 0.2023 KLHL21/NSFL1C/DIAPH1/MAPRE3/MAP1A 5 BP GO:0070830 bicellular tight junction assembly 5/819 55/18670 0.09262 0.2638 0.2023 RAMP2/GJA1/SNAI2/ARL2/WNT11 5 BP GO:0050821 protein stabilization 12/819 178/18670 0.09277 0.2638 0.2023 HIP1R/CRYAB/PIN1/SEL1L/GRN/PIK3R1/RASSF2/PPIB/ATP1B1/CCT7/PHB/SOX4 12 BP GO:0051260 protein homooligomerization 21/819 351/18670 0.09375 0.2638 0.2023 NACC2/CRYAB/ACOT13/PCBD1/ADCY8/EMILIN1/HRK/TGM2/SLC1A5/KCND3/DPYSL3/FBP1/ITPR3/PRMT1/GPX3/CHMP2A/SIGMAR1/ALDH1A3/CAT/ASIC1/HSF4 21 BP GO:0001562 response to protozoan 3/819 25/18670 0.09464 0.2638 0.2023 IL12A/LYST/IL4R 3 BP GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 3/819 25/18670 0.09464 0.2638 0.2023 PCSK5/GJA1/GAS6 3 BP GO:0009299 mRNA transcription 3/819 25/18670 0.09464 0.2638 0.2023 LMO2/HIF1A/STAT3 3 BP GO:0009404 toxin metabolic process 3/819 25/18670 0.09464 0.2638 0.2023 CYP1B1/FMO1/FMO2 3 BP GO:0014829 vascular smooth muscle contraction 3/819 25/18670 0.09464 0.2638 0.2023 COMP/EDNRA/ACTA2 3 BP GO:0019054 modulation by virus of host process 3/819 25/18670 0.09464 0.2638 0.2023 BCL2L1/BAD/KPNA3 3 BP GO:0021952 central nervous system projection neuron axonogenesis 3/819 25/18670 0.09464 0.2638 0.2023 CDH11/EPHB2/ADARB1 3 BP GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 3/819 25/18670 0.09464 0.2638 0.2023 CD55/PRKCA/SASH1 3 BP GO:0032438 melanosome organization 3/819 25/18670 0.09464 0.2638 0.2023 HPS1/RAB32/LYST 3 BP GO:0034035 purine ribonucleoside bisphosphate metabolic process 3/819 25/18670 0.09464 0.2638 0.2023 ENPP1/SULT1C2/SULT2B1 3 BP GO:0035235 ionotropic glutamate receptor signaling pathway 3/819 25/18670 0.09464 0.2638 0.2023 CLN3/GRIN2B/GRIN2A 3 BP GO:0035459 cargo loading into vesicle 3/819 25/18670 0.09464 0.2638 0.2023 SEC13/SEC23B/TMED2 3 BP GO:0045332 phospholipid translocation 3/819 25/18670 0.09464 0.2638 0.2023 ATP8A1/ATP11B/KCNN4 3 BP GO:0060444 branching involved in mammary gland duct morphogenesis 3/819 25/18670 0.09464 0.2638 0.2023 VDR/KDM5B/CAV3 3 BP GO:0060571 morphogenesis of an epithelial fold 3/819 25/18670 0.09464 0.2638 0.2023 BMP4/HIF1A/SULF1 3 BP GO:0090025 regulation of monocyte chemotaxis 3/819 25/18670 0.09464 0.2638 0.2023 GREM1/CXCL12/CCR1 3 BP GO:1900101 regulation of endoplasmic reticulum unfolded protein response 3/819 25/18670 0.09464 0.2638 0.2023 PIK3R1/HSPA5/NCK1 3 BP GO:0003334 keratinocyte development 2/819 12/18670 0.09483 0.2638 0.2023 PALLD/FLNB 2 BP GO:0006216 cytidine catabolic process 2/819 12/18670 0.09483 0.2638 0.2023 APOBEC3B/APOBEC3C 2 BP GO:0006465 signal peptide processing 2/819 12/18670 0.09483 0.2638 0.2023 PCSK5/SPCS2 2 BP GO:0006527 arginine catabolic process 2/819 12/18670 0.09483 0.2638 0.2023 DDAH2/FAH 2 BP GO:0006662 glycerol ether metabolic process 2/819 12/18670 0.09483 0.2638 0.2023 TXN/PEX7 2 BP GO:0007077 mitotic nuclear envelope disassembly 2/819 12/18670 0.09483 0.2638 0.2023 PRKCA/PRKCB 2 BP GO:0009886 post-embryonic animal morphogenesis 2/819 12/18670 0.09483 0.2638 0.2023 EFEMP1/HMGN1 2 BP GO:0009972 cytidine deamination 2/819 12/18670 0.09483 0.2638 0.2023 APOBEC3B/APOBEC3C 2 BP GO:0010623 programmed cell death involved in cell development 2/819 12/18670 0.09483 0.2638 0.2023 DNASE1L3/BCL2 2 BP GO:0010826 negative regulation of centrosome duplication 2/819 12/18670 0.09483 0.2638 0.2023 KAT2B/CHMP2A 2 BP GO:0010889 regulation of sequestering of triglyceride 2/819 12/18670 0.09483 0.2638 0.2023 ABHD5/PNPLA2 2 BP GO:0010896 regulation of triglyceride catabolic process 2/819 12/18670 0.09483 0.2638 0.2023 ABHD5/PNPLA2 2 BP GO:0014831 gastro-intestinal system smooth muscle contraction 2/819 12/18670 0.09483 0.2638 0.2023 SULF1/HTR2B 2 BP GO:0016554 cytidine to uridine editing 2/819 12/18670 0.09483 0.2638 0.2023 APOBEC3B/APOBEC3C 2 BP GO:0021559 trigeminal nerve development 2/819 12/18670 0.09483 0.2638 0.2023 NRP1/TFAP2A 2 BP GO:0030002 cellular anion homeostasis 2/819 12/18670 0.09483 0.2638 0.2023 ENPP1/CKB 2 BP GO:0030320 cellular monovalent inorganic anion homeostasis 2/819 12/18670 0.09483 0.2638 0.2023 ENPP1/CKB 2 BP GO:0031581 hemidesmosome assembly 2/819 12/18670 0.09483 0.2638 0.2023 CD151/ITGA6 2 BP GO:0032905 transforming growth factor beta1 production 2/819 12/18670 0.09483 0.2638 0.2023 THBS1/CD2AP 2 BP GO:0033197 response to vitamin E 2/819 12/18670 0.09483 0.2638 0.2023 COL1A1/CAT 2 BP GO:0035437 maintenance of protein localization in endoplasmic reticulum 2/819 12/18670 0.09483 0.2638 0.2023 KDELR3/HSPA5 2 BP GO:0035751 regulation of lysosomal lumen pH 2/819 12/18670 0.09483 0.2638 0.2023 CLN3/GRN 2 BP GO:0038003 opioid receptor signaling pathway 2/819 12/18670 0.09483 0.2638 0.2023 ADCY8/SIGMAR1 2 BP GO:0042308 negative regulation of protein import into nucleus 2/819 12/18670 0.09483 0.2638 0.2023 ANGPT1/MDFIC 2 BP GO:0042340 keratan sulfate catabolic process 2/819 12/18670 0.09483 0.2638 0.2023 FMOD/ACAN 2 BP GO:0044650 adhesion of symbiont to host cell 2/819 12/18670 0.09483 0.2638 0.2023 INHBB/GAS6 2 BP GO:0046087 cytidine metabolic process 2/819 12/18670 0.09483 0.2638 0.2023 APOBEC3B/APOBEC3C 2 BP GO:0051549 positive regulation of keratinocyte migration 2/819 12/18670 0.09483 0.2638 0.2023 HAS2/MTOR 2 BP GO:0055062 phosphate ion homeostasis 2/819 12/18670 0.09483 0.2638 0.2023 ENPP1/SFRP4 2 BP GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/819 12/18670 0.09483 0.2638 0.2023 TNRC6B/ZFP36 2 BP GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2/819 12/18670 0.09483 0.2638 0.2023 GREM1/EMILIN1 2 BP GO:0070243 regulation of thymocyte apoptotic process 2/819 12/18670 0.09483 0.2638 0.2023 BMP4/HIF1A 2 BP GO:0071107 response to parathyroid hormone 2/819 12/18670 0.09483 0.2638 0.2023 GJA1/ITGA2 2 BP GO:0071679 commissural neuron axon guidance 2/819 12/18670 0.09483 0.2638 0.2023 EPHB2/NRP1 2 BP GO:0071888 macrophage apoptotic process 2/819 12/18670 0.09483 0.2638 0.2023 IRF7/CDKN2A 2 BP GO:0072505 divalent inorganic anion homeostasis 2/819 12/18670 0.09483 0.2638 0.2023 ENPP1/SFRP4 2 BP GO:0072506 trivalent inorganic anion homeostasis 2/819 12/18670 0.09483 0.2638 0.2023 ENPP1/SFRP4 2 BP GO:0086067 AV node cell to bundle of His cell communication 2/819 12/18670 0.09483 0.2638 0.2023 GJC1/CACNA1C 2 BP GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 2/819 12/18670 0.09483 0.2638 0.2023 NPTX2/NPTX1 2 BP GO:0099150 regulation of postsynaptic specialization assembly 2/819 12/18670 0.09483 0.2638 0.2023 IL1RAP/GAP43 2 BP GO:0099550 trans-synaptic signaling, modulating synaptic transmission 2/819 12/18670 0.09483 0.2638 0.2023 EPHB2/NTRK2 2 BP GO:0150052 regulation of postsynapse assembly 2/819 12/18670 0.09483 0.2638 0.2023 IL1RAP/GAP43 2 BP GO:1902224 ketone body metabolic process 2/819 12/18670 0.09483 0.2638 0.2023 OXCT1/HMGCL 2 BP GO:1904590 negative regulation of protein import 2/819 12/18670 0.09483 0.2638 0.2023 ANGPT1/MDFIC 2 BP GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production 2/819 12/18670 0.09483 0.2638 0.2023 POSTN/KLF4 2 BP GO:2001223 negative regulation of neuron migration 2/819 12/18670 0.09483 0.2638 0.2023 COL3A1/STAT3 2 BP GO:0007030 Golgi organization 10/819 142/18670 0.09501 0.2641 0.2026 MAPK3/PI4K2A/NSFL1C/PRKD1/RAB29/PLEKHM2/CAMSAP2/COG4/LMAN1/TMED2 10 BP GO:0007043 cell-cell junction assembly 9/819 124/18670 0.09512 0.2642 0.2026 CDH11/PRKCA/RAMP2/GJA1/GJC1/SNAI2/FSCN1/ARL2/WNT11 9 BP GO:0048284 organelle fusion 9/819 124/18670 0.09512 0.2642 0.2026 VPS41/TBC1D4/VPS11/GOSR2/SPG11/VAT1/RAB8A/TAP1/VAMP3 9 BP GO:0006635 fatty acid beta-oxidation 6/819 72/18670 0.0957 0.2652 0.2034 ECI1/AUH/HADH/PEX7/MTOR/ETFB 6 BP GO:0009301 snRNA transcription 6/819 72/18670 0.0957 0.2652 0.2034 POLR2L/POLR2E/USPL1/SNAPC4/ELL2/SNAPC5 6 BP GO:1903747 regulation of establishment of protein localization to mitochondrion 6/819 72/18670 0.0957 0.2652 0.2034 VPS11/HAX1/NMT1/BAD/BCL2/LMAN1 6 BP GO:0006094 gluconeogenesis 7/819 89/18670 0.09574 0.2652 0.2034 KAT2B/FBP1/PDK2/PGM1/PER2/TPI1/MDH2 7 BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 7/819 89/18670 0.09574 0.2652 0.2034 ADCY8/ADCY7/PALM/RGS2/GABBR1/LPAR1/EDNRA 7 BP GO:0032943 mononuclear cell proliferation 17/819 274/18670 0.09588 0.2655 0.2036 CD55/CD151/BMP4/GJA1/CD70/IL12A/TNFRSF14/CD24/BST1/IL6ST/BCL2/PAWR/SDC4/PKN1/CTPS1/NCK1/HLA-DPB1 17 BP GO:0002369 T cell cytokine production 4/819 40/18670 0.09692 0.2673 0.205 CD55/IL18R1/IL12A/RSAD2 4 BP GO:0042036 negative regulation of cytokine biosynthetic process 4/819 40/18670 0.09692 0.2673 0.205 ASB1/INHBB/KLF4/ZFP36 4 BP GO:0045124 regulation of bone resorption 4/819 40/18670 0.09692 0.2673 0.205 PLEKHM1/PRKCA/ITGB3/TNFRSF11B 4 BP GO:0045823 positive regulation of heart contraction 4/819 40/18670 0.09692 0.2673 0.205 ATP2A2/TPM1/TGFB2/RGS2 4 BP GO:0071470 cellular response to osmotic stress 4/819 40/18670 0.09692 0.2673 0.205 MYLK/XRCC6/SERPINB6/BAD 4 BP GO:0090184 positive regulation of kidney development 4/819 40/18670 0.09692 0.2673 0.205 MAGED1/BMP4/PDGFA/CD24 4 BP GO:0090207 regulation of triglyceride metabolic process 4/819 40/18670 0.09692 0.2673 0.205 ABHD5/NR1H2/NR1H3/PNPLA2 4 BP GO:0017157 regulation of exocytosis 14/819 217/18670 0.09693 0.2673 0.205 STAM/ATP2A2/ITGB2/RAB27B/ABR/NAPA/IL13RA2/PRKCB/RAB8A/IL4R/CHMP2A/TSG101/UNC13B/SDC4 14 BP GO:0050905 neuromuscular process 8/819 107/18670 0.09806 0.2703 0.2073 CLN3/COMP/ADARB1/GM2A/ABR/GLRB/ALDH1A3/GRIN2A 8 BP GO:0098586 cellular response to virus 5/819 56/18670 0.09824 0.2705 0.2074 ADAR/IL12A/BCL2L1/IRF7/BAD 5 BP GO:0120192 tight junction assembly 5/819 56/18670 0.09824 0.2705 0.2074 RAMP2/GJA1/SNAI2/ARL2/WNT11 5 BP GO:0001701 in utero embryonic development 22/819 373/18670 0.09841 0.2708 0.2077 TANC2/ANGPT1/GJA1/TGFBR1/FOXC1/BCL2L1/SSR2/TPM1/MYH9/HIF1A/EPAS1/PRMT1/NMT1/SYF2/SOCS3/KDM6A/EDNRA/SH3PXD2A/BYSL/EIF2S2/TMED2/ITGB1 22 BP GO:0050863 regulation of T cell activation 19/819 314/18670 0.09848 0.2709 0.2078 CD55/BMP4/PIK3R1/CD70/IL12A/TNFRSF14/GSN/CD24/THY1/SOCS5/IL6ST/IL4R/BAD/PTPN11/PAWR/SDC4/NCK1/HLX/HLA-DPB1 19 BP GO:0030326 embryonic limb morphogenesis 9/819 125/18670 0.09875 0.2712 0.208 BMP4/GJA1/FBN2/TFAP2A/FZD6/TGFB2/ROR2/CACNA1C/CREBBP 9 BP GO:0031929 TOR signaling 9/819 125/18670 0.09875 0.2712 0.208 ARNTL/RRAGD/LAMTOR5/HIF1A/CLEC16A/GAS6/SEC13/MTOR/RPS6KB2 9 BP GO:0035113 embryonic appendage morphogenesis 9/819 125/18670 0.09875 0.2712 0.208 BMP4/GJA1/FBN2/TFAP2A/FZD6/TGFB2/ROR2/CACNA1C/CREBBP 9 BP GO:0048511 rhythmic process 18/819 295/18670 0.09966 0.2736 0.2098 ARNTL/SIAH2/KDM5B/NAGLU/MAGED1/NTRK2/CLDN4/HSPA5/KAT2B/NR1H3/HAS2/TGFB2/ARRB2/MTOR/PTX3/PER2/FOXO3/CREBBP 18 BP GO:0030901 midbrain development 7/819 90/18670 0.1001 0.2746 0.2106 HSPA5/PLP1/CKB/FZD6/NDUFS3/UQCRQ/FZD1 7 BP GO:0071674 mononuclear cell migration 7/819 90/18670 0.1001 0.2746 0.2106 MAPK3/GREM1/RARRES2/THBS1/CXCL12/CCR1/PLCB1 7 BP GO:0031960 response to corticosteroid 11/819 162/18670 0.1005 0.2754 0.2112 IGFBP7/ABCA3/SPARC/COL1A1/ANXA3/CNGA3/ZFP36/BAD/BCL2/CASP9/FOXO3 11 BP GO:0030239 myofibril assembly 6/819 73/18670 0.1006 0.2755 0.2113 TPM1/CSRP2/TMOD1/CAV3/LMOD1/ITGB1 6 BP GO:1901983 regulation of protein acetylation 6/819 73/18670 0.1006 0.2755 0.2113 MAPK3/ARNTL/SNAI2/WBP2/SOX4/CAMK1 6 BP GO:0031098 stress-activated protein kinase signaling cascade 19/819 315/18670 0.1007 0.2755 0.2113 MAPK3/MAP3K4/CRYAB/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/PRMT1/MAP4K2/RAPGEF1/CAV3/TGFB2/ZFP36/ROR2/MAP2K4/PLCB1/EZR/PKN1 19 BP GO:0051961 negative regulation of nervous system development 19/819 315/18670 0.1007 0.2755 0.2113 COL3A1/IDH2/CTSC/TRAK2/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/FIG4/THY1/ARHGEF15/STAT3/NOTCH3/PMP22/LPAR1/RAB29/TRPC6/FOXO3 19 BP GO:0050867 positive regulation of cell activation 23/819 394/18670 0.1008 0.2755 0.2113 CD55/CTSC/THBS1/PIK3R1/CD70/IL12A/ITGB2/TNFRSF14/CD24/THY1/BST1/JAK2/GAS6/SOCS5/IL6ST/IL4R/IGLL1/BAD/BCL2/PTPN11/NCK1/HLX/HLA-DPB1 23 BP GO:0022408 negative regulation of cell-cell adhesion 12/819 181/18670 0.1017 0.2779 0.2131 CXCL12/BMP4/TNFRSF14/SNAI2/PODXL/KLF4/JAK2/SOCS5/IL4R/PAWR/SDC4/HLX 12 BP GO:0051147 regulation of muscle cell differentiation 12/819 181/18670 0.1017 0.2779 0.2131 GREM1/PIN1/FZD7/BMP4/MAML1/CAV3/ARRB2/RGS2/IL4R/MTOR/BCL2/CAMK1 12 BP GO:1902107 positive regulation of leukocyte differentiation 10/819 144/18670 0.1018 0.278 0.2132 PRKCA/IL12A/HAX1/CCR1/GAS6/SOCS5/IL4R/BAD/ROR2/HLX 10 BP GO:0009062 fatty acid catabolic process 8/819 108/18670 0.1021 0.2785 0.2136 PLA2G15/ECI1/PCCB/AUH/HADH/PEX7/MTOR/ETFB 8 BP GO:0002360 T cell lineage commitment 3/819 26/18670 0.1037 0.2804 0.2151 STAT3/MTOR/BCL2 3 BP GO:0010758 regulation of macrophage chemotaxis 3/819 26/18670 0.1037 0.2804 0.2151 MAPK3/RARRES2/THBS1 3 BP GO:0030318 melanocyte differentiation 3/819 26/18670 0.1037 0.2804 0.2151 ENPP1/MYO5A/BCL2 3 BP GO:0032967 positive regulation of collagen biosynthetic process 3/819 26/18670 0.1037 0.2804 0.2151 BMP4/ARRB2/ITGA2 3 BP GO:0034204 lipid translocation 3/819 26/18670 0.1037 0.2804 0.2151 ATP8A1/ATP11B/KCNN4 3 BP GO:0042481 regulation of odontogenesis 3/819 26/18670 0.1037 0.2804 0.2151 BMP4/TFAP2A/TNFRSF11B 3 BP GO:0043090 amino acid import 3/819 26/18670 0.1037 0.2804 0.2151 SLC1A5/RGS2/PER2 3 BP GO:0048596 embryonic camera-type eye morphogenesis 3/819 26/18670 0.1037 0.2804 0.2151 TFAP2A/ALDH1A3/PHACTR4 3 BP GO:0051125 regulation of actin nucleation 3/819 26/18670 0.1037 0.2804 0.2151 HIP1R/GSN/GMFG 3 BP GO:0055083 monovalent inorganic anion homeostasis 3/819 26/18670 0.1037 0.2804 0.2151 ENPP1/SFRP4/CKB 3 BP GO:0060037 pharyngeal system development 3/819 26/18670 0.1037 0.2804 0.2151 BMP4/TGFBR1/TGFB2 3 BP GO:0060740 prostate gland epithelium morphogenesis 3/819 26/18670 0.1037 0.2804 0.2151 BMP4/SULF1/TNC 3 BP GO:0099560 synaptic membrane adhesion 3/819 26/18670 0.1037 0.2804 0.2151 IL1RAP/SPARCL1/GPC4 3 BP GO:1900120 regulation of receptor binding 3/819 26/18670 0.1037 0.2804 0.2151 ADAM15/NRP1/LOX 3 BP GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/819 26/18670 0.1037 0.2804 0.2151 NMT1/BAD/BCL2 3 BP GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/819 26/18670 0.1037 0.2804 0.2151 NMT1/BAD/BCL2 3 BP GO:1903579 negative regulation of ATP metabolic process 3/819 26/18670 0.1037 0.2804 0.2151 NUPR1/FBP1/STAT3 3 BP GO:0097178 ruffle assembly 4/819 41/18670 0.1039 0.2805 0.2151 PLEKHM1/EPS8/SH3YL1/PIP5K1A 4 BP GO:0098927 vesicle-mediated transport between endosomal compartments 4/819 41/18670 0.1039 0.2805 0.2151 MAPK3/PIK3C3/VPS11/EZR 4 BP GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 4/819 41/18670 0.1039 0.2805 0.2151 BMP4/HIF1A/STAT3/TGFB2 4 BP GO:1903170 negative regulation of calcium ion transmembrane transport 4/819 41/18670 0.1039 0.2805 0.2151 GSTO1/CLIC2/GNB5/BIN1 4 BP GO:0002066 columnar/cuboidal epithelial cell development 5/819 57/18670 0.104 0.2805 0.2151 ARNTL/RFX3/BMP4/HIF1A/BAD 5 BP GO:0042743 hydrogen peroxide metabolic process 5/819 57/18670 0.104 0.2805 0.2151 CTNS/PXDN/STAT3/GPX3/CAT 5 BP GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 5/819 57/18670 0.104 0.2805 0.2151 NADK/OXCT1/ADCY8/HIF1A/BAD 5 BP GO:0030510 regulation of BMP signaling pathway 7/819 91/18670 0.1046 0.2816 0.216 SFRP4/GREM1/BMP4/ITGA3/SULF1/FZD1/ZNF423 7 BP GO:0051899 membrane depolarization 7/819 91/18670 0.1046 0.2816 0.216 MYOC/GJA1/GCLM/CAV3/GPD1L/BCL2/CACNA1C 7 BP GO:1904063 negative regulation of cation transmembrane transport 7/819 91/18670 0.1046 0.2816 0.216 GSTO1/CLIC2/EPHB2/GNB5/CAV3/RGS2/BIN1 7 BP GO:0050804 modulation of chemical synaptic transmission 25/819 436/18670 0.1048 0.2818 0.2161 CDH11/PTPRA/ADCY8/ATP2A2/EPHB2/NTRK2/NPTX2/ABR/ITPR3/NAPA/STAT3/ARRB2/NPTX1/JAK2/GRIN2B/PRKCB/RAB8A/MTOR/UNC13B/ROR2/PLCB1/MAP1A/ASIC1/GRIN2A/ITGB1 25 BP GO:2000116 regulation of cysteine-type endopeptidase activity 15/819 239/18670 0.1048 0.2818 0.2161 HIP1R/CRYAB/SIAH2/THBS1/LAMTOR5/MAP3K5/GSN/ARRB2/KLF4/JAK2/GAS6/GRIN2B/BAD/CASP9/GRIN2A 15 BP GO:0008217 regulation of blood pressure 12/819 182/18670 0.1048 0.2818 0.2161 RENBP/PCSK5/PRCP/COL1A2/POSTN/RAMP2/GJA1/VEGFC/TPM1/GAS6/EDNRA/ACTA2 12 BP GO:0006865 amino acid transport 10/819 145/18670 0.1053 0.283 0.217 CTNS/SLC7A8/CLN3/PPFIA4/NTRK2/SV2A/SLC1A5/RGS2/UNC13B/PER2 10 BP GO:0006081 cellular aldehyde metabolic process 6/819 74/18670 0.1057 0.2835 0.2174 IDH2/CYP1B1/HAGH/ALDH1A3/TPI1/ALDH7A1 6 BP GO:0032418 lysosome localization 6/819 74/18670 0.1057 0.2835 0.2174 PLEKHM1/MYH9/S100A13/IL13RA2/IL4R/PLEKHM2 6 BP GO:0099601 regulation of neurotransmitter receptor activity 6/819 74/18670 0.1057 0.2835 0.2174 EPHB2/NPTX2/ANXA3/NPTX1/GRIN2B/GRIN2A 6 BP GO:0001676 long-chain fatty acid metabolic process 8/819 109/18670 0.1062 0.2846 0.2183 MAPK3/CYP1B1/PLA2G4C/ELOVL2/PLP1/CYP3A4/MYO5A/GPX4 8 BP GO:0045727 positive regulation of translation 9/819 127/18670 0.1062 0.2846 0.2183 MAPK3/THBS1/HABP4/SAMD4A/MTOR/RPS6KB2/ITGA2/SOX4/NCK1 9 BP GO:0071426 ribonucleoprotein complex export from nucleus 9/819 127/18670 0.1062 0.2846 0.2183 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/SEC13/SRSF7/AGFG1 9 BP GO:0099177 regulation of trans-synaptic signaling 25/819 437/18670 0.1068 0.2859 0.2193 CDH11/PTPRA/ADCY8/ATP2A2/EPHB2/NTRK2/NPTX2/ABR/ITPR3/NAPA/STAT3/ARRB2/NPTX1/JAK2/GRIN2B/PRKCB/RAB8A/MTOR/UNC13B/ROR2/PLCB1/MAP1A/ASIC1/GRIN2A/ITGB1 25 BP GO:0051604 protein maturation 23/819 397/18670 0.107 0.2862 0.2195 CD55/PCSK5/THBS1/CLN3/SERPINH1/COMP/SPCS2/KAT2B/NDUFAB1/C1S/MYH9/PIK3C3/ISCA1/GSN/CIAO1/C1R/SPON1/BAD/PHB/SOX4/CPM/GRIN2A/CREBBP 23 BP GO:0038061 NIK/NF-kappaB signaling 12/819 183/18670 0.108 0.2863 0.2196 IL18R1/PSMD8/PSMB7/PSMD1/SASH1/RASSF2/PSMB6/COPS8/CHI3L1/PSMD3/PSMD2/PSMB8 12 BP GO:0000722 telomere maintenance via recombination 2/819 13/18670 0.1089 0.2863 0.2196 SMC5/TERF2 2 BP GO:0002829 negative regulation of type 2 immune response 2/819 13/18670 0.1089 0.2863 0.2196 SOCS5/HLX 2 BP GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity 2/819 13/18670 0.1089 0.2863 0.2196 GREM1/ANGPT1 2 BP GO:0008298 intracellular mRNA localization 2/819 13/18670 0.1089 0.2863 0.2196 ZFP36/EXOSC2 2 BP GO:0009162 deoxyribonucleoside monophosphate metabolic process 2/819 13/18670 0.1089 0.2863 0.2196 TK2/GUK1 2 BP GO:0010763 positive regulation of fibroblast migration 2/819 13/18670 0.1089 0.2863 0.2196 THBS1/DDR2 2 BP GO:0014745 negative regulation of muscle adaptation 2/819 13/18670 0.1089 0.2863 0.2196 KLF4/MTOR 2 BP GO:0019896 axonal transport of mitochondrion 2/819 13/18670 0.1089 0.2863 0.2196 TRAK2/HIF1A 2 BP GO:0030497 fatty acid elongation 2/819 13/18670 0.1089 0.2863 0.2196 ELOVL2/TECR 2 BP GO:0030656 regulation of vitamin metabolic process 2/819 13/18670 0.1089 0.2863 0.2196 VDR/SNAI2 2 BP GO:0032536 regulation of cell projection size 2/819 13/18670 0.1089 0.2863 0.2196 TWF2/EZR 2 BP GO:0035723 interleukin-15-mediated signaling pathway 2/819 13/18670 0.1089 0.2863 0.2196 STAT3/PLCB1 2 BP GO:0038007 netrin-activated signaling pathway 2/819 13/18670 0.1089 0.2863 0.2196 SIAH2/UNC5B 2 BP GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/819 13/18670 0.1089 0.2863 0.2196 SOCS3/PPP2R1A 2 BP GO:0042761 very long-chain fatty acid biosynthetic process 2/819 13/18670 0.1089 0.2863 0.2196 ELOVL2/TECR 2 BP GO:0043116 negative regulation of vascular permeability 2/819 13/18670 0.1089 0.2863 0.2196 RAMP2/ANGPT1 2 BP GO:0043301 negative regulation of leukocyte degranulation 2/819 13/18670 0.1089 0.2863 0.2196 ABR/IL13RA2 2 BP GO:0045759 negative regulation of action potential 2/819 13/18670 0.1089 0.2863 0.2196 CAV3/BIN1 2 BP GO:0046349 amino sugar biosynthetic process 2/819 13/18670 0.1089 0.2863 0.2196 RENBP/GNPDA1 2 BP GO:0048711 positive regulation of astrocyte differentiation 2/819 13/18670 0.1089 0.2863 0.2196 IL6ST/BIN1 2 BP GO:0050872 white fat cell differentiation 2/819 13/18670 0.1089 0.2863 0.2196 SNAI2/PER2 2 BP GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 2/819 13/18670 0.1089 0.2863 0.2196 CXCL12/ITGA2 2 BP GO:0051451 myoblast migration 2/819 13/18670 0.1089 0.2863 0.2196 THBS4/ITGB1BP1 2 BP GO:0060601 lateral sprouting from an epithelium 2/819 13/18670 0.1089 0.2863 0.2196 BMP4/SULF1 2 BP GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development 2/819 13/18670 0.1089 0.2863 0.2196 CAV3/RGS2 2 BP GO:0070208 protein heterotrimerization 2/819 13/18670 0.1089 0.2863 0.2196 COL1A2/COL1A1 2 BP GO:0071027 nuclear RNA surveillance 2/819 13/18670 0.1089 0.2863 0.2196 EXOSC7/EXOSC2 2 BP GO:0071028 nuclear mRNA surveillance 2/819 13/18670 0.1089 0.2863 0.2196 EXOSC7/EXOSC2 2 BP GO:0071350 cellular response to interleukin-15 2/819 13/18670 0.1089 0.2863 0.2196 STAT3/PLCB1 2 BP GO:0072182 regulation of nephron tubule epithelial cell differentiation 2/819 13/18670 0.1089 0.2863 0.2196 WWTR1/CD24 2 BP GO:0090594 inflammatory response to wounding 2/819 13/18670 0.1089 0.2863 0.2196 GRN/HIF1A 2 BP GO:0097152 mesenchymal cell apoptotic process 2/819 13/18670 0.1089 0.2863 0.2196 ETV6/HIF1A 2 BP GO:1900025 negative regulation of substrate adhesion-dependent cell spreading 2/819 13/18670 0.1089 0.2863 0.2196 POSTN/ITGB1BP1 2 BP GO:1903651 positive regulation of cytoplasmic transport 2/819 13/18670 0.1089 0.2863 0.2196 VPS11/EZR 2 BP GO:1903726 negative regulation of phospholipid metabolic process 2/819 13/18670 0.1089 0.2863 0.2196 PIK3IP1/PDGFA 2 BP GO:2000009 negative regulation of protein localization to cell surface 2/819 13/18670 0.1089 0.2863 0.2196 GPM6B/CAV3 2 BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 7/819 92/18670 0.1092 0.2869 0.22 CRYAB/SIAH2/THBS1/LAMTOR5/ARRB2/KLF4/GAS6 7 BP GO:0098930 axonal transport 5/819 58/18670 0.11 0.2888 0.2215 TRAK2/RAB27B/HIF1A/TERF2/MAP1A 5 BP GO:0051291 protein heterooligomerization 9/819 128/18670 0.1101 0.2889 0.2215 COL1A2/PCBD1/COL1A1/XRCC6/ITPR3/GLRB/GRIN2B/CHMP2A/RRM2 9 BP GO:0071166 ribonucleoprotein complex localization 9/819 128/18670 0.1101 0.2889 0.2215 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/SEC13/SRSF7/AGFG1 9 BP GO:0006664 glycolipid metabolic process 8/819 110/18670 0.1104 0.2894 0.222 ST3GAL5/CTSA/CLN3/ESYT1/GM2A/PIGH/ASAH1/DPM2 8 BP GO:0071695 anatomical structure maturation 11/819 165/18670 0.1105 0.2895 0.222 GREM1/MYOC/RFX3/GJA1/MYO5A/HIF1A/TGFB2/MTOR/BCL2/PPP2R1A/FOXO3 11 BP GO:0010611 regulation of cardiac muscle hypertrophy 6/819 75/18670 0.1109 0.29 0.2224 PIN1/PRKCA/CAV3/RGS2/IL6ST/MTOR 6 BP GO:0032482 Rab protein signal transduction 6/819 75/18670 0.1109 0.29 0.2224 RAB32/RAB33A/RAB27B/RAB8A/RAB29/RAB28 6 BP GO:0046173 polyol biosynthetic process 6/819 75/18670 0.1109 0.29 0.2224 PCBD1/QDPR/CYP3A4/CYP27A1/ASAH1/PLCB1 6 BP GO:0150076 neuroinflammatory response 6/819 75/18670 0.1109 0.29 0.2224 CTSC/ADCY8/GRN/NUPR1/ITGB2/JAK2 6 BP GO:0010470 regulation of gastrulation 4/819 42/18670 0.111 0.29 0.2224 COL5A2/FZD7/TGIF2/KLF4 4 BP GO:0010613 positive regulation of cardiac muscle hypertrophy 4/819 42/18670 0.111 0.29 0.2224 PIN1/PRKCA/IL6ST/MTOR 4 BP GO:0010677 negative regulation of cellular carbohydrate metabolic process 4/819 42/18670 0.111 0.29 0.2224 ENPP1/NUPR1/FBP1/STAT3 4 BP GO:0000460 maturation of 5.8S rRNA 3/819 27/18670 0.113 0.2943 0.2257 EXOSC7/RRS1/EXOSC2 3 BP GO:0010714 positive regulation of collagen metabolic process 3/819 27/18670 0.113 0.2943 0.2257 BMP4/ARRB2/ITGA2 3 BP GO:0043032 positive regulation of macrophage activation 3/819 27/18670 0.113 0.2943 0.2257 CTSC/THBS1/IL4R 3 BP GO:0046885 regulation of hormone biosynthetic process 3/819 27/18670 0.113 0.2943 0.2257 VDR/STC2/HIF1A 3 BP GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 3/819 27/18670 0.113 0.2943 0.2257 GJA1/SNTA1/CAV3 3 BP GO:1905208 negative regulation of cardiocyte differentiation 3/819 27/18670 0.113 0.2943 0.2257 FZD7/CAV3/RGS2 3 BP GO:0002696 positive regulation of leukocyte activation 22/819 380/18670 0.1134 0.2953 0.2265 CD55/CTSC/THBS1/PIK3R1/CD70/IL12A/ITGB2/TNFRSF14/CD24/THY1/BST1/GAS6/SOCS5/IL6ST/IL4R/IGLL1/BAD/BCL2/PTPN11/NCK1/HLX/HLA-DPB1 22 BP GO:0007589 body fluid secretion 7/819 93/18670 0.1139 0.2961 0.2271 VDR/OAS2/GJA1/NR1H3/HIF1A/KCNN4/P2RY2 7 BP GO:0072080 nephron tubule development 7/819 93/18670 0.1139 0.2961 0.2271 MTSS1/MAGED1/BMP4/WWTR1/CD24/WNT11/BCL2 7 BP GO:1901184 regulation of ERBB signaling pathway 7/819 93/18670 0.1139 0.2961 0.2271 STAM/HIP1R/DOK1/SH3GL2/ITGA1/SOCS5/TSG101 7 BP GO:0009799 specification of symmetry 9/819 129/18670 0.1141 0.2962 0.2272 GREM1/PCSK5/MICAL2/RFX3/BMP4/GJA1/BICC1/HIF1A/TMED2 9 BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 9/819 129/18670 0.1141 0.2962 0.2272 CXCL12/BMP4/TNFRSF14/KLF4/SOCS5/IL4R/PAWR/SDC4/HLX 9 BP GO:0031396 regulation of protein ubiquitination 13/819 204/18670 0.1144 0.2969 0.2277 SIAH2/PIN1/ISG15/ANGPT1/TGFBR1/HSPA5/SASH1/ARRB2/PTTG1IP/MTOR/PER2/SOX4/RCHY1 13 BP GO:0046328 regulation of JNK cascade 12/819 185/18670 0.1145 0.2969 0.2277 MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/MAP4K2/RAPGEF1/ROR2/MAP2K4/PLCB1/PKN1 12 BP GO:0006406 mRNA export from nucleus 8/819 111/18670 0.1147 0.2971 0.2279 THOC1/DDX39A/NUP205/NUP93/NUP153/SEC13/SRSF7/AGFG1 8 BP GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 8/819 111/18670 0.1147 0.2971 0.2279 THOC1/DDX39A/NUP205/NUP93/NUP153/SEC13/SRSF7/AGFG1 8 BP GO:1903509 liposaccharide metabolic process 8/819 111/18670 0.1147 0.2971 0.2279 ST3GAL5/CTSA/CLN3/ESYT1/GM2A/PIGH/ASAH1/DPM2 8 BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 21/819 361/18670 0.1157 0.2995 0.2297 CD55/THOC1/IL18R1/CTSC/MICB/CD70/IL12A/C1S/IL13RA2/STAT3/C1R/RSAD2/SOCS5/IL4R/MTOR/IGLL1/HLA-DQB1/IRF7/TCIRG1/PKN1/HLX 21 BP GO:0010518 positive regulation of phospholipase activity 5/819 59/18670 0.1161 0.2999 0.23 NTRK2/ARF4/LPAR1/HTR2B/EDNRA 5 BP GO:0043388 positive regulation of DNA binding 5/819 59/18670 0.1161 0.2999 0.23 TXN/FOXC1/KLF4/JAK2/ITGA2 5 BP GO:0045824 negative regulation of innate immune response 5/819 59/18670 0.1161 0.2999 0.23 GRN/ADAR/NR1H2/NR1H3/ARRB2 5 BP GO:0045843 negative regulation of striated muscle tissue development 5/819 59/18670 0.1161 0.2999 0.23 FZD7/BMP4/GJA1/CAV3/RGS2 5 BP GO:0001937 negative regulation of endothelial cell proliferation 6/819 76/18670 0.1162 0.2999 0.23 THBS1/SPARC/GJA1/SCG2/TGFBR1/SULF1 6 BP GO:0019674 NAD metabolic process 6/819 76/18670 0.1162 0.2999 0.23 NADK/LDHA/BST1/GPD1L/TPI1/MDH2 6 BP GO:0042310 vasoconstriction 6/819 76/18670 0.1162 0.2999 0.23 COMP/GJA1/HTR2B/EDNRA/ACTA2/PER2 6 BP GO:0070507 regulation of microtubule cytoskeleton organization 12/819 186/18670 0.1178 0.3038 0.233 NSFL1C/KAT2B/CIB1/FKBP4/MET/ARL2/MAPRE3/CAV3/CHMP2A/CLIP1/CAMSAP2/MAP1A 12 BP GO:0050671 positive regulation of lymphocyte proliferation 9/819 130/18670 0.1181 0.3042 0.2333 CD55/CD70/IL12A/CD24/BST1/IL6ST/BCL2/NCK1/HLA-DPB1 9 BP GO:0003009 skeletal muscle contraction 4/819 43/18670 0.1184 0.3042 0.2333 GSTO1/ATP2A2/CAV3/STAC 4 BP GO:0009163 nucleoside biosynthetic process 4/819 43/18670 0.1184 0.3042 0.2333 NME3/TK2/GUK1/CTPS1 4 BP GO:0010863 positive regulation of phospholipase C activity 4/819 43/18670 0.1184 0.3042 0.2333 NTRK2/LPAR1/HTR2B/EDNRA 4 BP GO:0014742 positive regulation of muscle hypertrophy 4/819 43/18670 0.1184 0.3042 0.2333 PIN1/PRKCA/IL6ST/MTOR 4 BP GO:0021762 substantia nigra development 4/819 43/18670 0.1184 0.3042 0.2333 HSPA5/PLP1/CKB/NDUFS3 4 BP GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 4/819 43/18670 0.1184 0.3042 0.2333 PTK7/ARF4/LAMA1/WNT11 4 BP GO:0055026 negative regulation of cardiac muscle tissue development 4/819 43/18670 0.1184 0.3042 0.2333 FZD7/GJA1/CAV3/RGS2 4 BP GO:0070296 sarcoplasmic reticulum calcium ion transport 4/819 43/18670 0.1184 0.3042 0.2333 GSTO1/CLIC2/ATP2A2/CACNA1C 4 BP GO:0016579 protein deubiquitination 17/819 283/18670 0.1187 0.3045 0.2335 STAM/SIAH2/USP5/PSMD8/PSMB7/RAD23A/TGFBR1/PSMD1/KAT2B/HIF1A/PSMB6/ARRB2/USP10/NEDD8/PSMD3/PSMD2/PSMB8 17 BP GO:0032409 regulation of transporter activity 17/819 283/18670 0.1187 0.3045 0.2335 GSTO1/CLIC2/EPHB2/GJA1/HSPA2/MYO5A/PDE4B/GNB5/ANXA3/CAV3/ATP1B1/STAC/GRIN2B/GPD1L/BCL2/TRPC6/GRIN2A 17 BP GO:0060993 kidney morphogenesis 7/819 94/18670 0.1187 0.3045 0.2335 MAGED1/BMP4/WWTR1/WNT11/BCL2/SOX4/PRKX 7 BP GO:0014902 myotube differentiation 8/819 112/18670 0.1191 0.3051 0.234 ADAM12/MAML1/MYH9/CAV3/IL4R/MTOR/BCL2/DYRK1B 8 BP GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 8/819 112/18670 0.1191 0.3051 0.234 BCL2L1/PPIB/CHD1/IFI27/BAD/FBXL2/PTX3/KPNA3 8 BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 10/819 149/18670 0.12 0.3075 0.2358 IL18R1/IL1RAP/PRKD1/ITGB2/TRIM25/CIB1/LRRFIP1/STAT3/PRKCB/CAT 10 BP GO:0002237 response to molecule of bacterial origin 20/819 343/18670 0.1203 0.308 0.2362 MAPK3/CD55/MAPKAPK3/SPARC/PRKCA/ATP2A2/GJA1/IL12A/HNRNPA0/NR1H2/SASH1/NR1H3/FMO1/ABR/PDE4B/CD24/GNG12/JAK2/ZFP36/CASP9 20 BP GO:1901343 negative regulation of vasculature development 12/819 187/18670 0.1211 0.3081 0.2363 THBS4/THBS1/SPARC/EMILIN1/BMP4/FOXC1/HSPG2/TGFB2/KLF4/ITGB1BP1/SULF1/COL4A2 12 BP GO:0021700 developmental maturation 17/819 284/18670 0.1214 0.3081 0.2363 GREM1/MYOC/RAB32/RFX3/GJA1/MYO5A/DEFB1/HIF1A/EPAS1/PALM/ARHGEF15/TGFB2/MTOR/UNC13B/BCL2/PPP2R1A/FOXO3 17 BP GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 6/819 77/18670 0.1216 0.3081 0.2363 EXOSC7/SAMD4A/TNRC6B/ZFP36/EXOSC2/LSM4 6 BP GO:0006278 RNA-dependent DNA biosynthetic process 6/819 77/18670 0.1216 0.3081 0.2363 MAPK3/MAP3K4/NEK7/TERF2/NHP2/CCT7 6 BP GO:0032946 positive regulation of mononuclear cell proliferation 9/819 131/18670 0.1222 0.3081 0.2363 CD55/CD70/IL12A/CD24/BST1/IL6ST/BCL2/NCK1/HLA-DPB1 9 BP GO:0098754 detoxification 9/819 131/18670 0.1222 0.3081 0.2363 GSTO1/CLIC2/PXDN/TXN/SOD3/GPX4/GPX3/FBLN5/CAT 9 BP GO:0048635 negative regulation of muscle organ development 5/819 60/18670 0.1223 0.3081 0.2363 FZD7/BMP4/GJA1/CAV3/RGS2 5 BP GO:0090342 regulation of cell aging 5/819 60/18670 0.1223 0.3081 0.2363 ARNTL/TERF2/PAWR/HMGA1/CDKN2A 5 BP GO:0009074 aromatic amino acid family catabolic process 3/819 28/18670 0.1227 0.3081 0.2363 PCBD1/QDPR/FAH 3 BP GO:0032770 positive regulation of monooxygenase activity 3/819 28/18670 0.1227 0.3081 0.2363 HIF1A/TERF2/HTR2B 3 BP GO:0033137 negative regulation of peptidyl-serine phosphorylation 3/819 28/18670 0.1227 0.3081 0.2363 RASSF2/GPD1L/NCK1 3 BP GO:0036296 response to increased oxygen levels 3/819 28/18670 0.1227 0.3081 0.2363 COL1A1/ATP6V0D1/CAT 3 BP GO:0043501 skeletal muscle adaptation 3/819 28/18670 0.1227 0.3081 0.2363 MYOC/ATP2A2/MTOR 3 BP GO:0050858 negative regulation of antigen receptor-mediated signaling pathway 3/819 28/18670 0.1227 0.3081 0.2363 THY1/PAWR/EZR 3 BP GO:0060512 prostate gland morphogenesis 3/819 28/18670 0.1227 0.3081 0.2363 BMP4/SULF1/TNC 3 BP GO:1900543 negative regulation of purine nucleotide metabolic process 3/819 28/18670 0.1227 0.3081 0.2363 NUPR1/FBP1/STAT3 3 BP GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 3/819 28/18670 0.1227 0.3081 0.2363 CXCL12/ITGB2/KLF4 3 BP GO:2001025 positive regulation of response to drug 3/819 28/18670 0.1227 0.3081 0.2363 CXCL12/PAWR/FOXO3 3 BP GO:0006241 CTP biosynthetic process 2/819 14/18670 0.1235 0.3081 0.2363 NME3/CTPS1 2 BP GO:0006878 cellular copper ion homeostasis 2/819 14/18670 0.1235 0.3081 0.2363 SLC31A2/ATOX1 2 BP GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 2/819 14/18670 0.1235 0.3081 0.2363 SOCS5/TSG101 2 BP GO:0010752 regulation of cGMP-mediated signaling 2/819 14/18670 0.1235 0.3081 0.2363 THBS1/RUNDC3A 2 BP GO:0010867 positive regulation of triglyceride biosynthetic process 2/819 14/18670 0.1235 0.3081 0.2363 NR1H2/NR1H3 2 BP GO:0014819 regulation of skeletal muscle contraction 2/819 14/18670 0.1235 0.3081 0.2363 GSTO1/CAV3 2 BP GO:0014854 response to inactivity 2/819 14/18670 0.1235 0.3081 0.2363 SGCA/CAT 2 BP GO:0030213 hyaluronan biosynthetic process 2/819 14/18670 0.1235 0.3081 0.2363 CEMIP/HAS2 2 BP GO:0032802 low-density lipoprotein particle receptor catabolic process 2/819 14/18670 0.1235 0.3081 0.2363 AP2B1/VLDLR 2 BP GO:0033169 histone H3-K9 demethylation 2/819 14/18670 0.1235 0.3081 0.2363 PHF2/HSF4 2 BP GO:0042487 regulation of odontogenesis of dentin-containing tooth 2/819 14/18670 0.1235 0.3081 0.2363 BMP4/TNFRSF11B 2 BP GO:0042574 retinal metabolic process 2/819 14/18670 0.1235 0.3081 0.2363 CYP1B1/ALDH1A3 2 BP GO:0045198 establishment of epithelial cell apical/basal polarity 2/819 14/18670 0.1235 0.3081 0.2363 PTK7/LAMA1 2 BP GO:0045651 positive regulation of macrophage differentiation 2/819 14/18670 0.1235 0.3081 0.2363 PRKCA/ROR2 2 BP GO:0046036 CTP metabolic process 2/819 14/18670 0.1235 0.3081 0.2363 NME3/CTPS1 2 BP GO:0046133 pyrimidine ribonucleoside catabolic process 2/819 14/18670 0.1235 0.3081 0.2363 APOBEC3B/APOBEC3C 2 BP GO:0046606 negative regulation of centrosome cycle 2/819 14/18670 0.1235 0.3081 0.2363 KAT2B/CHMP2A 2 BP GO:0046855 inositol phosphate dephosphorylation 2/819 14/18670 0.1235 0.3081 0.2363 SYNJ2/INPP5E 2 BP GO:0048266 behavioral response to pain 2/819 14/18670 0.1235 0.3081 0.2363 THBS4/THBS1 2 BP GO:0050862 positive regulation of T cell receptor signaling pathway 2/819 14/18670 0.1235 0.3081 0.2363 KCNN4/RAB29 2 BP GO:0051547 regulation of keratinocyte migration 2/819 14/18670 0.1235 0.3081 0.2363 HAS2/MTOR 2 BP GO:0051917 regulation of fibrinolysis 2/819 14/18670 0.1235 0.3081 0.2363 THBS1/FAP 2 BP GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 2/819 14/18670 0.1235 0.3081 0.2363 TNRC6B/ZFP36 2 BP GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development 2/819 14/18670 0.1235 0.3081 0.2363 PIN1/MTOR 2 BP GO:0070672 response to interleukin-15 2/819 14/18670 0.1235 0.3081 0.2363 STAT3/PLCB1 2 BP GO:0071361 cellular response to ethanol 2/819 14/18670 0.1235 0.3081 0.2363 ADCY7/KCNMB1 2 BP GO:0072498 embryonic skeletal joint development 2/819 14/18670 0.1235 0.3081 0.2363 BMP4/EXT1 2 BP GO:0072567 chemokine (C-X-C motif) ligand 2 production 2/819 14/18670 0.1235 0.3081 0.2363 POSTN/KLF4 2 BP GO:0090110 cargo loading into COPII-coated vesicle 2/819 14/18670 0.1235 0.3081 0.2363 SEC13/SEC23B 2 BP GO:0097202 activation of cysteine-type endopeptidase activity 2/819 14/18670 0.1235 0.3081 0.2363 BAD/GRIN2A 2 BP GO:1901070 guanosine-containing compound biosynthetic process 2/819 14/18670 0.1235 0.3081 0.2363 NME3/GUK1 2 BP GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 2/819 14/18670 0.1235 0.3081 0.2363 GREM1/BMP4 2 BP GO:1902570 protein localization to nucleolus 2/819 14/18670 0.1235 0.3081 0.2363 RRS1/BYSL 2 BP GO:1903054 negative regulation of extracellular matrix organization 2/819 14/18670 0.1235 0.3081 0.2363 EMILIN1/FAP 2 BP GO:1905050 positive regulation of metallopeptidase activity 2/819 14/18670 0.1235 0.3081 0.2363 MAPK3/STAT3 2 BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 8/819 113/18670 0.1235 0.3081 0.2363 PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8/CREBBP 8 BP GO:0046620 regulation of organ growth 8/819 113/18670 0.1235 0.3081 0.2363 PIN1/GJA1/TGFBR1/FOXC1/CAV3/RGS2/MTOR/HLX 8 BP GO:0042102 positive regulation of T cell proliferation 7/819 95/18670 0.1236 0.3081 0.2363 CD55/CD70/IL12A/CD24/IL6ST/NCK1/HLA-DPB1 7 BP GO:0042116 macrophage activation 7/819 95/18670 0.1236 0.3081 0.2363 CTSC/THBS1/GRN/ITGB2/NR1H3/JAK2/IL4R 7 BP GO:0044070 regulation of anion transport 7/819 95/18670 0.1236 0.3081 0.2363 SFRP4/ATP8A1/THBS1/SV2A/RGS2/MTOR/PER2 7 BP GO:0007338 single fertilization 10/819 150/18670 0.1239 0.3085 0.2366 KDM5B/FOLR3/FOLR2/SPA17/GLRB/GNPDA1/UNC13B/CCT7/PLCB1/TRPC6 10 BP GO:0008203 cholesterol metabolic process 10/819 150/18670 0.1239 0.3085 0.2366 TM7SF2/ABCG1/FDXR/LBR/CYP27A1/SULT2B1/MBTPS1/CAT/VLDLR/NFYB 10 BP GO:0006367 transcription initiation from RNA polymerase II promoter 12/819 188/18670 0.1246 0.31 0.2378 VDR/POLR2L/POLR2E/MAML1/KAT2B/NR1H2/WWTR1/NR1H3/TEAD3/NOTCH3/CREBBP/TEAD4 12 BP GO:0043547 positive regulation of GTPase activity 23/819 405/18670 0.1246 0.3101 0.2378 RANGAP1/PIN1/TBC1D4/ABR/IQGAP1/NRP1/GNB5/CHN1/RAPGEF1/THY1/ARHGEF15/RASA1/RGS2/ITGA6/ARFGAP2/WNT11/PLCB1/HTR2B/RABGAP1L/SEC23B/PIP5K1A/AGFG1/ITGB1 23 BP GO:0006869 lipid transport 21/819 365/18670 0.1252 0.3114 0.2388 ATP8A1/ABCA3/THBS1/KDM5B/GRAMD1B/ESYT1/ABCG1/NR1H2/GM2A/NR1H3/ATP11B/ABCC4/GULP1/PLTP/ITGB3/KCNN4/SIGMAR1/STOML1/PTPN11/TMF1/VLDLR 21 BP GO:0003197 endocardial cushion development 4/819 44/18670 0.126 0.3119 0.2392 BMP4/TGFBR1/SNAI2/TGFB2 4 BP GO:0014002 astrocyte development 4/819 44/18670 0.126 0.3119 0.2392 GRN/PLP1/TSPAN2/ROR2 4 BP GO:0030225 macrophage differentiation 4/819 44/18670 0.126 0.3119 0.2392 PRKCA/BMP4/TSPAN2/ROR2 4 BP GO:0032965 regulation of collagen biosynthetic process 4/819 44/18670 0.126 0.3119 0.2392 EMILIN1/BMP4/ARRB2/ITGA2 4 BP GO:0046189 phenol-containing compound biosynthetic process 4/819 44/18670 0.126 0.3119 0.2392 CTNS/MYO5A/TYR/TGFB2 4 BP GO:0046688 response to copper ion 4/819 44/18670 0.126 0.3119 0.2392 SORD/SOD3/S100A13/LOXL2 4 BP GO:0050982 detection of mechanical stimulus 4/819 44/18670 0.126 0.3119 0.2392 COL11A1/CXCL12/CAV3/ITGA2 4 BP GO:0061756 leukocyte adhesion to vascular endothelial cell 4/819 44/18670 0.126 0.3119 0.2392 CXCL12/ITGB2/KLF4/ITGB1 4 BP GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4/819 44/18670 0.126 0.3119 0.2392 HIP1R/NMT1/BAD/BCL2 4 BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 4/819 44/18670 0.126 0.3119 0.2392 HSPA5/BCL2L1/UBE2J1/NCK1 4 BP GO:0010827 regulation of glucose transmembrane transport 6/819 78/18670 0.1272 0.314 0.2408 ENPP1/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11 6 BP GO:0014743 regulation of muscle hypertrophy 6/819 78/18670 0.1272 0.314 0.2408 PIN1/PRKCA/CAV3/RGS2/IL6ST/MTOR 6 BP GO:0055021 regulation of cardiac muscle tissue growth 6/819 78/18670 0.1272 0.314 0.2408 PIN1/GJA1/TGFBR1/CAV3/RGS2/MTOR 6 BP GO:0061333 renal tubule morphogenesis 6/819 78/18670 0.1272 0.314 0.2408 MTSS1/MAGED1/BMP4/COL4A1/WNT11/BCL2 6 BP GO:0070664 negative regulation of leukocyte proliferation 6/819 78/18670 0.1272 0.314 0.2408 GREM1/BMP4/TNFRSF14/PAWR/SDC4/PKN1 6 BP GO:0090398 cellular senescence 6/819 78/18670 0.1272 0.314 0.2408 ARNTL/SMC5/TERF2/PAWR/HMGA1/CDKN2A 6 BP GO:0010660 regulation of muscle cell apoptotic process 7/819 96/18670 0.1286 0.317 0.2431 NUPR1/IL12A/MAP3K5/ARRB2/JAK2/MAP2K4/CDKN2A 7 BP GO:0030219 megakaryocyte differentiation 7/819 96/18670 0.1286 0.317 0.2431 THBS1/KAT2B/CIB1/LOX/TNRC6B/PRMT1/PTPN11 7 BP GO:0007405 neuroblast proliferation 5/819 61/18670 0.1288 0.317 0.2431 VEGFC/SOX5/HIF1A/TEAD3/EML1 5 BP GO:0034113 heterotypic cell-cell adhesion 5/819 61/18670 0.1288 0.317 0.2431 ITGB2/ITGB3/THY1/KLF4/ITGB1 5 BP GO:0042490 mechanoreceptor differentiation 5/819 61/18670 0.1288 0.317 0.2431 NAGLU/BMP4/NTRK2/FZD2/SDC4 5 BP GO:0042733 embryonic digit morphogenesis 5/819 61/18670 0.1288 0.317 0.2431 BMP4/GJA1/FZD6/ROR2/CREBBP 5 BP GO:0006006 glucose metabolic process 13/819 209/18670 0.1307 0.3215 0.2466 ENPP1/SORD/OAS1/KAT2B/FBP1/PDK1/MTOR/BAD/PDK2/PGM1/PER2/TPI1/MDH2 13 BP GO:0001890 placenta development 10/819 152/18670 0.1318 0.3233 0.248 MAPK3/VDR/MAP3K4/STC2/GJA1/HIF1A/EPAS1/ADAM19/SOCS3/TMED2 10 BP GO:0051028 mRNA transport 10/819 152/18670 0.1318 0.3233 0.248 THOC1/DDX39A/NUP205/NUP93/NUP153/ZFP36/SEC13/SRSF7/AGFG1/MX2 10 BP GO:0007263 nitric oxide mediated signal transduction 3/819 29/18670 0.1326 0.3233 0.248 FPR1/THBS1/DDAH2 3 BP GO:0007628 adult walking behavior 3/819 29/18670 0.1326 0.3233 0.248 CTNS/ARRB2/GLRB 3 BP GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3/819 29/18670 0.1326 0.3233 0.248 CEMIP/CHI3L1/TRPC6 3 BP GO:0021884 forebrain neuron development 3/819 29/18670 0.1326 0.3233 0.248 NRP1/UQCRQ/NRP2 3 BP GO:0031114 regulation of microtubule depolymerization 3/819 29/18670 0.1326 0.3233 0.248 CIB1/CAMSAP2/MAP1A 3 BP GO:0044068 modulation by symbiont of host cellular process 3/819 29/18670 0.1326 0.3233 0.248 BCL2L1/BAD/KPNA3 3 BP GO:0044550 secondary metabolite biosynthetic process 3/819 29/18670 0.1326 0.3233 0.248 CTNS/MYO5A/TYR 3 BP GO:0045822 negative regulation of heart contraction 3/819 29/18670 0.1326 0.3233 0.248 ATP2A2/JAK2/BIN1 3 BP GO:0045980 negative regulation of nucleotide metabolic process 3/819 29/18670 0.1326 0.3233 0.248 NUPR1/FBP1/STAT3 3 BP GO:0046134 pyrimidine nucleoside biosynthetic process 3/819 29/18670 0.1326 0.3233 0.248 NME3/TK2/CTPS1 3 BP GO:0048730 epidermis morphogenesis 3/819 29/18670 0.1326 0.3233 0.248 TGFB2/KLF4/BCL2 3 BP GO:0050974 detection of mechanical stimulus involved in sensory perception 3/819 29/18670 0.1326 0.3233 0.248 COL11A1/CXCL12/ITGA2 3 BP GO:0060441 epithelial tube branching involved in lung morphogenesis 3/819 29/18670 0.1326 0.3233 0.248 BMP4/LAMA1/TNC 3 BP GO:0061099 negative regulation of protein tyrosine kinase activity 3/819 29/18670 0.1326 0.3233 0.248 THY1/SOCS5/TSG101 3 BP GO:0070528 protein kinase C signaling 3/819 29/18670 0.1326 0.3233 0.248 GPD1L/WNT11/HTR2B 3 BP GO:0090162 establishment of epithelial cell polarity 3/819 29/18670 0.1326 0.3233 0.248 PTK7/LAMA1/CYTH1 3 BP GO:1900027 regulation of ruffle assembly 3/819 29/18670 0.1326 0.3233 0.248 PLEKHM1/EPS8/SH3YL1 3 BP GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3/819 29/18670 0.1326 0.3233 0.248 SOCS5/IL4R/HLX 3 BP GO:0007032 endosome organization 6/819 79/18670 0.1329 0.3238 0.2483 PI4K2A/STAM/PIK3C3/VPS11/CHMP2A/TSG101 6 BP GO:0045652 regulation of megakaryocyte differentiation 6/819 79/18670 0.1329 0.3238 0.2483 THBS1/KAT2B/CIB1/LOX/TNRC6B/PRMT1 6 BP GO:0010771 negative regulation of cell morphogenesis involved in differentiation 7/819 97/18670 0.1337 0.3252 0.2494 TRAK2/POSTN/EPHB2/NRP1/THY1/ITGB1BP1/TRPC6 7 BP GO:0045581 negative regulation of T cell differentiation 4/819 45/18670 0.1338 0.3252 0.2494 BMP4/SOCS5/IL4R/HLX 4 BP GO:0048538 thymus development 4/819 45/18670 0.1338 0.3252 0.2494 MAPK3/TGFBR1/TYR/BCL2 4 BP GO:0048701 embryonic cranial skeleton morphogenesis 4/819 45/18670 0.1338 0.3252 0.2494 BMP4/TGFBR1/TFAP2A/MTHFD1 4 BP GO:1900274 regulation of phospholipase C activity 4/819 45/18670 0.1338 0.3252 0.2494 NTRK2/LPAR1/HTR2B/EDNRA 4 BP GO:1902743 regulation of lamellipodium organization 4/819 45/18670 0.1338 0.3252 0.2494 TWF2/FSCN1/MTOR/ENPP2 4 BP GO:0006352 DNA-templated transcription, initiation 15/819 249/18670 0.134 0.3254 0.2496 MAPK3/VDR/POLR2L/POLR2E/MAML1/KAT2B/NR1H2/WWTR1/NR1H3/TEAD3/NOTCH3/SNAPC5/POLRMT/CREBBP/TEAD4 15 BP GO:0002260 lymphocyte homeostasis 5/819 62/18670 0.1353 0.3274 0.2511 HIF1A/TNFRSF17/BCL2/TCIRG1/PKN1 5 BP GO:0009880 embryonic pattern specification 5/819 62/18670 0.1353 0.3274 0.2511 SATB2/NRP1/KDM6A/NRP2/TMED2 5 BP GO:0010830 regulation of myotube differentiation 5/819 62/18670 0.1353 0.3274 0.2511 MAML1/CAV3/IL4R/MTOR/BCL2 5 BP GO:0045453 bone resorption 5/819 62/18670 0.1353 0.3274 0.2511 PLEKHM1/PRKCA/ITGB3/TNFRSF11B/TCIRG1 5 BP GO:0046635 positive regulation of alpha-beta T cell activation 5/819 62/18670 0.1353 0.3274 0.2511 CD55/IL12A/SOCS5/IL4R/HLX 5 BP GO:0046824 positive regulation of nucleocytoplasmic transport 5/819 62/18670 0.1353 0.3274 0.2511 TCF7L2/PIK3R1/PIK3R2/GAS6/CAMK1 5 BP GO:0055025 positive regulation of cardiac muscle tissue development 5/819 62/18670 0.1353 0.3274 0.2511 GREM1/PIN1/BMP4/ARRB2/MTOR 5 BP GO:1901862 negative regulation of muscle tissue development 5/819 62/18670 0.1353 0.3274 0.2511 FZD7/BMP4/GJA1/CAV3/RGS2 5 BP GO:1904356 regulation of telomere maintenance via telomere lengthening 5/819 62/18670 0.1353 0.3274 0.2511 MAPK3/MAP3K4/NEK7/TERF2/CCT7 5 BP GO:0034250 positive regulation of cellular amide metabolic process 10/819 153/18670 0.1358 0.3284 0.2519 MAPK3/THBS1/ABCG1/HABP4/SAMD4A/MTOR/RPS6KB2/ITGA2/SOX4/NCK1 10 BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 8/819 116/18670 0.1374 0.329 0.2524 PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8/CREBBP 8 BP GO:0007569 cell aging 8/819 116/18670 0.1374 0.329 0.2524 ARNTL/SMC5/TERF2/MTOR/BCL2/PAWR/HMGA1/CDKN2A 8 BP GO:1903531 negative regulation of secretion by cell 13/819 211/18670 0.1375 0.329 0.2524 IDH2/ANGPT1/NR1H3/ABR/INHBB/HADH/IL13RA2/GAS6/RSAD2/PTPN11/ASIC1/EZR/VAMP3 13 BP GO:0032496 response to lipopolysaccharide 19/819 330/18670 0.1385 0.329 0.2524 MAPK3/CD55/MAPKAPK3/SPARC/PRKCA/ATP2A2/GJA1/IL12A/HNRNPA0/NR1H2/SASH1/NR1H3/FMO1/ABR/PDE4B/GNG12/JAK2/ZFP36/CASP9 19 BP GO:0001921 positive regulation of receptor recycling 2/819 15/18670 0.1386 0.329 0.2524 RAB29/VAMP3 2 BP GO:0006000 fructose metabolic process 2/819 15/18670 0.1386 0.329 0.2524 SORD/FBP1 2 BP GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 2/819 15/18670 0.1386 0.329 0.2524 UQCRQ/UQCRC1 2 BP GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process 2/819 15/18670 0.1386 0.329 0.2524 NME3/CTPS1 2 BP GO:0009263 deoxyribonucleotide biosynthetic process 2/819 15/18670 0.1386 0.329 0.2524 GUK1/RRM2 2 BP GO:0018158 protein oxidation 2/819 15/18670 0.1386 0.329 0.2524 LOX/LOXL2 2 BP GO:0032274 gonadotropin secretion 2/819 15/18670 0.1386 0.329 0.2524 INHBB/TMF1 2 BP GO:0033689 negative regulation of osteoblast proliferation 2/819 15/18670 0.1386 0.329 0.2524 GREM1/BCL2 2 BP GO:0036445 neuronal stem cell division 2/819 15/18670 0.1386 0.329 0.2524 SOX5/TEAD3 2 BP GO:0042762 regulation of sulfur metabolic process 2/819 15/18670 0.1386 0.329 0.2524 PDK1/PDK2 2 BP GO:0042921 glucocorticoid receptor signaling pathway 2/819 15/18670 0.1386 0.329 0.2524 ARNTL/PHB 2 BP GO:0042976 activation of Janus kinase activity 2/819 15/18670 0.1386 0.329 0.2524 GHR/JAK2 2 BP GO:0042983 amyloid precursor protein biosynthetic process 2/819 15/18670 0.1386 0.329 0.2524 ITM2B/PAWR 2 BP GO:0042984 regulation of amyloid precursor protein biosynthetic process 2/819 15/18670 0.1386 0.329 0.2524 ITM2B/PAWR 2 BP GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 2/819 15/18670 0.1386 0.329 0.2524 SNAI2/PTTG1IP 2 BP GO:0043652 engulfment of apoptotic cell 2/819 15/18670 0.1386 0.329 0.2524 THBS1/RHOBTB2 2 BP GO:0044406 adhesion of symbiont to host 2/819 15/18670 0.1386 0.329 0.2524 INHBB/GAS6 2 BP GO:0045475 locomotor rhythm 2/819 15/18670 0.1386 0.329 0.2524 NAGLU/MTOR 2 BP GO:0045838 positive regulation of membrane potential 2/819 15/18670 0.1386 0.329 0.2524 CTNS/BAD 2 BP GO:0046838 phosphorylated carbohydrate dephosphorylation 2/819 15/18670 0.1386 0.329 0.2524 SYNJ2/INPP5E 2 BP GO:0046851 negative regulation of bone remodeling 2/819 15/18670 0.1386 0.329 0.2524 GREM1/TNFRSF11B 2 BP GO:0050961 detection of temperature stimulus involved in sensory perception 2/819 15/18670 0.1386 0.329 0.2524 CXCL12/ARRB2 2 BP GO:0050965 detection of temperature stimulus involved in sensory perception of pain 2/819 15/18670 0.1386 0.329 0.2524 CXCL12/ARRB2 2 BP GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 2/819 15/18670 0.1386 0.329 0.2524 GSTO1/CLIC2 2 BP GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 2/819 15/18670 0.1386 0.329 0.2524 JAK2/MAP2K4 2 BP GO:0055057 neuroblast division 2/819 15/18670 0.1386 0.329 0.2524 SOX5/TEAD3 2 BP GO:0060026 convergent extension 2/819 15/18670 0.1386 0.329 0.2524 PTK7/WNT11 2 BP GO:0071025 RNA surveillance 2/819 15/18670 0.1386 0.329 0.2524 EXOSC7/EXOSC2 2 BP GO:0071801 regulation of podosome assembly 2/819 15/18670 0.1386 0.329 0.2524 GSN/FSCN1 2 BP GO:0090136 epithelial cell-cell adhesion 2/819 15/18670 0.1386 0.329 0.2524 THBS4/CYP1B1 2 BP GO:0090197 positive regulation of chemokine secretion 2/819 15/18670 0.1386 0.329 0.2524 POSTN/IL4R 2 BP GO:0097428 protein maturation by iron-sulfur cluster transfer 2/819 15/18670 0.1386 0.329 0.2524 ISCA1/CIAO1 2 BP GO:1900029 positive regulation of ruffle assembly 2/819 15/18670 0.1386 0.329 0.2524 PLEKHM1/EPS8 2 BP GO:1902188 positive regulation of viral release from host cell 2/819 15/18670 0.1386 0.329 0.2524 CHMP2A/TSG101 2 BP GO:1903358 regulation of Golgi organization 2/819 15/18670 0.1386 0.329 0.2524 MAPK3/CAMSAP2 2 BP GO:1904874 positive regulation of telomerase RNA localization to Cajal body 2/819 15/18670 0.1386 0.329 0.2524 NHP2/CCT7 2 BP GO:2001028 positive regulation of endothelial cell chemotaxis 2/819 15/18670 0.1386 0.329 0.2524 PRKD1/MET 2 BP GO:0022617 extracellular matrix disassembly 6/819 80/18670 0.1387 0.3292 0.2525 BMP1/ADAM15/FAP/FSCN1/DDR2/CAPNS1 6 BP GO:0050848 regulation of calcium-mediated signaling 7/819 98/18670 0.1389 0.3297 0.2528 GSTO1/CLIC2/CIB1/MYO5A/BST1/MTOR/PDK2 7 BP GO:1903320 regulation of protein modification by small protein conjugation or removal 14/819 231/18670 0.1392 0.3301 0.2531 SIAH2/PIN1/ISG15/ANGPT1/TGFBR1/HSPA5/SASH1/ARRB2/PTTG1IP/UBE2I/MTOR/PER2/SOX4/RCHY1 14 BP GO:0006405 RNA export from nucleus 9/819 135/18670 0.1393 0.3301 0.2532 THOC1/DDX39A/NUP205/NUP93/NUP153/RRS1/SEC13/SRSF7/AGFG1 9 BP GO:0010324 membrane invagination 9/819 135/18670 0.1393 0.3301 0.2532 THBS1/ITGB2/MYH9/GULP1/GSN/CHMP2A/IGLL1/ITGA2/RHOBTB2 9 BP GO:0052547 regulation of peptidase activity 25/819 452/18670 0.1395 0.3304 0.2534 RENBP/MAPK3/HIP1R/CRYAB/SIAH2/THBS1/SERPINH1/GRN/LAMTOR5/MAP3K5/COL6A3/GSN/COL7A1/SERPINB6/STAT3/ARRB2/KLF4/JAK2/GAS6/GRIN2B/BAD/BIN1/CASP9/PSMB8/GRIN2A 25 BP GO:0016525 negative regulation of angiogenesis 11/819 173/18670 0.1397 0.3307 0.2536 THBS4/THBS1/SPARC/EMILIN1/FOXC1/HSPG2/TGFB2/KLF4/ITGB1BP1/SULF1/COL4A2 11 BP GO:0002067 glandular epithelial cell differentiation 4/819 46/18670 0.1418 0.3347 0.2567 ARNTL/RFX3/BMP4/BAD 4 BP GO:0005978 glycogen biosynthetic process 4/819 46/18670 0.1418 0.3347 0.2567 ENPP1/MTOR/PGM1/PER2 4 BP GO:0009250 glucan biosynthetic process 4/819 46/18670 0.1418 0.3347 0.2567 ENPP1/MTOR/PGM1/PER2 4 BP GO:0032527 protein exit from endoplasmic reticulum 4/819 46/18670 0.1418 0.3347 0.2567 SEL1L/TM9SF4/UBE2J1/SEC13 4 BP GO:0043300 regulation of leukocyte degranulation 4/819 46/18670 0.1418 0.3347 0.2567 ITGB2/ABR/IL13RA2/IL4R 4 BP GO:0048599 oocyte development 4/819 46/18670 0.1418 0.3347 0.2567 INHBB/BCL2/PPP2R1A/FOXO3 4 BP GO:0060443 mammary gland morphogenesis 4/819 46/18670 0.1418 0.3347 0.2567 VDR/KDM5B/BMP4/CAV3 4 BP GO:0046530 photoreceptor cell differentiation 5/819 63/18670 0.1421 0.335 0.2569 NAGLU/NTRK2/TUG1/THY1/STAT3 5 BP GO:0046686 response to cadmium ion 5/819 63/18670 0.1421 0.335 0.2569 MAPK3/SPARC/SORD/GSN/CAT 5 BP GO:0002761 regulation of myeloid leukocyte differentiation 8/819 117/18670 0.1423 0.335 0.2569 PRKCA/PIK3R1/RASSF2/HAX1/CCR1/MTOR/IRF7/ROR2 8 BP GO:0001782 B cell homeostasis 3/819 30/18670 0.1428 0.335 0.2569 HIF1A/BCL2/PKN1 3 BP GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3/819 30/18670 0.1428 0.335 0.2569 NMT1/BAD/BCL2 3 BP GO:0035066 positive regulation of histone acetylation 3/819 30/18670 0.1428 0.335 0.2569 MAPK3/SNAI2/WBP2 3 BP GO:0036258 multivesicular body assembly 3/819 30/18670 0.1428 0.335 0.2569 STAM/CHMP2A/TSG101 3 BP GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 3/819 30/18670 0.1428 0.335 0.2569 SOCS5/IL4R/HLX 3 BP GO:0046596 regulation of viral entry into host cell 3/819 30/18670 0.1428 0.335 0.2569 TRIM25/GSN/PTX3 3 BP GO:0048873 homeostasis of number of cells within a tissue 3/819 30/18670 0.1428 0.335 0.2569 LIPA/BCL2/PTPN11 3 BP GO:0050869 negative regulation of B cell activation 3/819 30/18670 0.1428 0.335 0.2569 THOC1/PAWR/PKN1 3 BP GO:0099068 postsynapse assembly 3/819 30/18670 0.1428 0.335 0.2569 EPHB2/IL1RAP/GAP43 3 BP GO:1904837 beta-catenin-TCF complex assembly 3/819 30/18670 0.1428 0.335 0.2569 TCF7L2/TLE4/CREBBP 3 BP GO:1905606 regulation of presynapse assembly 3/819 30/18670 0.1428 0.335 0.2569 IL1RAP/GPC4/FZD1 3 BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 6/819 81/18670 0.1446 0.3388 0.2599 LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2 6 BP GO:0060761 negative regulation of response to cytokine stimulus 6/819 81/18670 0.1446 0.3388 0.2599 PXDN/ADAR/NR1H2/NR1H3/KLF4/GAS6 6 BP GO:0110110 positive regulation of animal organ morphogenesis 6/819 81/18670 0.1446 0.3388 0.2599 VDR/MAGED1/BMP4/TGFBR1/TFAP2A/TGFB2 6 BP GO:0006911 phagocytosis, engulfment 8/819 118/18670 0.1472 0.3446 0.2643 THBS1/ITGB2/MYH9/GULP1/GSN/IGLL1/ITGA2/RHOBTB2 8 BP GO:2000181 negative regulation of blood vessel morphogenesis 11/819 175/18670 0.1476 0.3455 0.265 THBS4/THBS1/SPARC/EMILIN1/FOXC1/HSPG2/TGFB2/KLF4/ITGB1BP1/SULF1/COL4A2 11 BP GO:0016051 carbohydrate biosynthetic process 13/819 214/18670 0.1481 0.3465 0.2657 ENPP1/NDST1/SORD/KAT2B/FBP1/HAS2/EXT1/MTOR/PDK2/PGM1/PER2/TPI1/MDH2 13 BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 13/819 214/18670 0.1481 0.3465 0.2657 CTSC/USP5/RAD23A/NUPR1/RNF144A/CLEC16A/UBE2J1/CAV3/SOCS5/MAP1A/RYBP/RCHY1/TMF1 13 BP GO:0046425 regulation of JAK-STAT cascade 9/819 137/18670 0.1483 0.3467 0.2659 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3/PPP2R1A 9 BP GO:0007259 JAK-STAT cascade 10/819 156/18670 0.1484 0.3467 0.2659 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/SOCS5/IL6ST/SOCS3/PPP2R1A 10 BP GO:0006360 transcription by RNA polymerase I 5/819 64/18670 0.1489 0.3468 0.266 MAPK3/POLR2L/POLR2E/WDR43/MTOR 5 BP GO:0035773 insulin secretion involved in cellular response to glucose stimulus 5/819 64/18670 0.1489 0.3468 0.266 NADK/OXCT1/ADCY8/HIF1A/BAD 5 BP GO:0035794 positive regulation of mitochondrial membrane permeability 5/819 64/18670 0.1489 0.3468 0.266 HIP1R/NMT1/BAD/BCL2/HEBP2 5 BP GO:0036498 IRE1-mediated unfolded protein response 5/819 64/18670 0.1489 0.3468 0.266 KDELR3/ATP6V0D1/HSPA5/GOSR2/CTDSP2 5 BP GO:0043297 apical junction assembly 5/819 64/18670 0.1489 0.3468 0.266 RAMP2/GJA1/SNAI2/ARL2/WNT11 5 BP GO:0046503 glycerolipid catabolic process 5/819 64/18670 0.1489 0.3468 0.266 PLA2G15/ABHD5/PLA2G4C/PNPLA2/ENPP2 5 BP GO:0048278 vesicle docking 5/819 64/18670 0.1489 0.3468 0.266 VPS11/RAB8A/UNC13B/VPS45/VAMP3 5 BP GO:1900449 regulation of glutamate receptor signaling pathway 5/819 64/18670 0.1489 0.3468 0.266 EPHB2/ANXA3/GRIN2B/FRRS1L/GRIN2A 5 BP GO:0007215 glutamate receptor signaling pathway 7/819 100/18670 0.1497 0.3479 0.2668 CLN3/EPHB2/ANXA3/GRIN2B/PLCB1/FRRS1L/GRIN2A 7 BP GO:0010657 muscle cell apoptotic process 7/819 100/18670 0.1497 0.3479 0.2668 NUPR1/IL12A/MAP3K5/ARRB2/JAK2/MAP2K4/CDKN2A 7 BP GO:0035282 segmentation 7/819 100/18670 0.1497 0.3479 0.2668 BMP4/FOXC1/NRP1/ROR2/KDM6A/NRP2/TMED2 7 BP GO:0051251 positive regulation of lymphocyte activation 19/819 334/18670 0.1498 0.3479 0.2668 CD55/PIK3R1/CD70/IL12A/TNFRSF14/CD24/THY1/BST1/GAS6/SOCS5/IL6ST/IL4R/IGLL1/BAD/BCL2/PTPN11/NCK1/HLX/HLA-DPB1 19 BP GO:0010799 regulation of peptidyl-threonine phosphorylation 4/819 47/18670 0.15 0.3479 0.2668 CEMIP/PPP2R5D/CHI3L1/TRPC6 4 BP GO:0035722 interleukin-12-mediated signaling pathway 4/819 47/18670 0.15 0.3479 0.2668 GSTO1/IL12A/JAK2/PLCB1 4 BP GO:0042461 photoreceptor cell development 4/819 47/18670 0.15 0.3479 0.2668 NAGLU/NTRK2/TUG1/THY1 4 BP GO:0050435 amyloid-beta metabolic process 4/819 47/18670 0.15 0.3479 0.2668 PIN1/ABCG1/SPON1/BIN1 4 BP GO:1901659 glycosyl compound biosynthetic process 4/819 47/18670 0.15 0.3479 0.2668 NME3/TK2/GUK1/CTPS1 4 BP GO:0010833 telomere maintenance via telomere lengthening 6/819 82/18670 0.1507 0.3479 0.2668 MAPK3/MAP3K4/NEK7/TERF2/NHP2/CCT7 6 BP GO:0030279 negative regulation of ossification 6/819 82/18670 0.1507 0.3479 0.2668 ENPP1/GREM1/CHSY1/HIF1A/CCR1/BCL2 6 BP GO:0032642 regulation of chemokine production 6/819 82/18670 0.1507 0.3479 0.2668 POSTN/SNAI2/HIF1A/KLF4/SOCS5/IL4R 6 BP GO:1905954 positive regulation of lipid localization 6/819 82/18670 0.1507 0.3479 0.2668 ATP8A1/ABCG1/NR1H2/NR1H3/PLTP/TMF1 6 BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 13/819 215/18670 0.1518 0.3479 0.2668 HIP1R/CRYAB/SIAH2/THBS1/LAMTOR5/MAP3K5/GSN/ARRB2/KLF4/JAK2/GAS6/BAD/CASP9 13 BP GO:0016311 dephosphorylation 26/819 478/18670 0.1526 0.3479 0.2668 SYNJ2/PPP1R7/PTPRA/PIN1/ITGA1/IQGAP1/FBP1/PTPRK/FIG4/ANKLE2/TGFB2/JAK2/DUSP7/MTOR/BCL2/INPP5E/ENSA/PPP2R1A/CSRNP2/ITGA2/PPP2R5D/PTPN11/CTDSP2/PHACTR4/PTPRB/NCK1 26 BP GO:0030509 BMP signaling pathway 10/819 157/18670 0.1527 0.3479 0.2668 MAPK3/SFRP4/GREM1/COMP/BMP4/ITGA3/SULF1/ROR2/FZD1/ZNF423 10 BP GO:0060560 developmental growth involved in morphogenesis 14/819 235/18670 0.1529 0.3479 0.2668 KDM5B/SH3GL2/CXCL12/POSTN/BMP4/PTK7/IQGAP1/NRP1/SPG11/TWF2/WNT11/TNC/NRP2/ITGB1 14 BP GO:0008584 male gonad development 9/819 138/18670 0.1529 0.3479 0.2668 GJA1/TGFBR1/NUPR1/ADAM15/BCL2L1/TGFB2/BCL2/EIF2S2/TMF1 9 BP GO:0031338 regulation of vesicle fusion 3/819 31/18670 0.1533 0.3479 0.2668 VPS41/TBC1D4/VPS11 3 BP GO:0032786 positive regulation of DNA-templated transcription, elongation 3/819 31/18670 0.1533 0.3479 0.2668 THOC1/HMGN1/SUPT4H1 3 BP GO:0036257 multivesicular body organization 3/819 31/18670 0.1533 0.3479 0.2668 STAM/CHMP2A/TSG101 3 BP GO:0050849 negative regulation of calcium-mediated signaling 3/819 31/18670 0.1533 0.3479 0.2668 GSTO1/CLIC2/MTOR 3 BP GO:0070306 lens fiber cell differentiation 3/819 31/18670 0.1533 0.3479 0.2668 KDM5B/TDRD7/TMOD1 3 BP GO:0099174 regulation of presynapse organization 3/819 31/18670 0.1533 0.3479 0.2668 IL1RAP/GPC4/FZD1 3 BP GO:1902186 regulation of viral release from host cell 3/819 31/18670 0.1533 0.3479 0.2668 TRIM25/CHMP2A/TSG101 3 BP GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 3/819 31/18670 0.1533 0.3479 0.2668 HIF1A/STAT3/TGFB2 3 BP GO:0006694 steroid biosynthetic process 12/819 196/18670 0.1539 0.3479 0.2668 VDR/TM7SF2/IGFBP7/ABCG1/FDXR/LBR/SNAI2/CYP3A4/CYP27A1/ASAH1/MBTPS1/NFYB 12 BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 12/819 196/18670 0.1539 0.3479 0.2668 PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/PSMB6/SYF2/PPP2R1A/PSMD3/CKAP5/PSMD2/PSMB8 12 BP GO:0001732 formation of cytoplasmic translation initiation complex 2/819 16/18670 0.154 0.3479 0.2668 EIF3I/EIF2S2 2 BP GO:0001780 neutrophil homeostasis 2/819 16/18670 0.154 0.3479 0.2668 PDE4B/PIK3CB 2 BP GO:0001946 lymphangiogenesis 2/819 16/18670 0.154 0.3479 0.2668 FOXC1/VEGFC 2 BP GO:0001977 renal system process involved in regulation of blood volume 2/819 16/18670 0.154 0.3479 0.2668 GJA1/GAS6 2 BP GO:0002295 T-helper cell lineage commitment 2/819 16/18670 0.154 0.3479 0.2668 STAT3/MTOR 2 BP GO:0002830 positive regulation of type 2 immune response 2/819 16/18670 0.154 0.3479 0.2668 RSAD2/IL4R 2 BP GO:0003222 ventricular trabecula myocardium morphogenesis 2/819 16/18670 0.154 0.3479 0.2668 TGFBR1/TGFB2 2 BP GO:0006047 UDP-N-acetylglucosamine metabolic process 2/819 16/18670 0.154 0.3479 0.2668 RENBP/GNPDA1 2 BP GO:0006086 acetyl-CoA biosynthetic process from pyruvate 2/819 16/18670 0.154 0.3479 0.2668 PDK1/PDK2 2 BP GO:0006103 2-oxoglutarate metabolic process 2/819 16/18670 0.154 0.3479 0.2668 IDH2/OGDH 2 BP GO:0006206 pyrimidine nucleobase metabolic process 2/819 16/18670 0.154 0.3479 0.2668 MTOR/CTPS1 2 BP GO:0006837 serotonin transport 2/819 16/18670 0.154 0.3479 0.2668 ITGB3/GPM6B 2 BP GO:0007567 parturition 2/819 16/18670 0.154 0.3479 0.2668 ARNTL/PLA2G4C 2 BP GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process 2/819 16/18670 0.154 0.3479 0.2668 NME3/CTPS1 2 BP GO:0010225 response to UV-C 2/819 16/18670 0.154 0.3479 0.2668 MAP3K4/HMGN1 2 BP GO:0010934 macrophage cytokine production 2/819 16/18670 0.154 0.3479 0.2668 TGFB2/GAS6 2 BP GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 2/819 16/18670 0.154 0.3479 0.2668 PIK3IP1/KLF4 2 BP GO:0014744 positive regulation of muscle adaptation 2/819 16/18670 0.154 0.3479 0.2668 MTOR/FOXO3 2 BP GO:0022038 corpus callosum development 2/819 16/18670 0.154 0.3479 0.2668 EPHB2/LPAR1 2 BP GO:0030397 membrane disassembly 2/819 16/18670 0.154 0.3479 0.2668 PRKCA/PRKCB 2 BP GO:0030575 nuclear body organization 2/819 16/18670 0.154 0.3479 0.2668 HABP4/USPL1 2 BP GO:0030889 negative regulation of B cell proliferation 2/819 16/18670 0.154 0.3479 0.2668 PAWR/PKN1 2 BP GO:0030952 establishment or maintenance of cytoskeleton polarity 2/819 16/18670 0.154 0.3479 0.2668 KIF2C/CKAP5 2 BP GO:0032695 negative regulation of interleukin-12 production 2/819 16/18670 0.154 0.3479 0.2668 THBS1/ARRB2 2 BP GO:0033033 negative regulation of myeloid cell apoptotic process 2/819 16/18670 0.154 0.3479 0.2668 IRF7/BCL2 2 BP GO:0033631 cell-cell adhesion mediated by integrin 2/819 16/18670 0.154 0.3479 0.2668 PODXL/ITGB1 2 BP GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 2/819 16/18670 0.154 0.3479 0.2668 HIP1R/GMFG 2 BP GO:0043031 negative regulation of macrophage activation 2/819 16/18670 0.154 0.3479 0.2668 GRN/NR1H3 2 BP GO:0045618 positive regulation of keratinocyte differentiation 2/819 16/18670 0.154 0.3479 0.2668 VDR/FOXC1 2 BP GO:0045989 positive regulation of striated muscle contraction 2/819 16/18670 0.154 0.3479 0.2668 GSTO1/RGS2 2 BP GO:0046325 negative regulation of glucose import 2/819 16/18670 0.154 0.3479 0.2668 ENPP1/GRB10 2 BP GO:0048012 hepatocyte growth factor receptor signaling pathway 2/819 16/18670 0.154 0.3479 0.2668 NRP1/MET 2 BP GO:0048820 hair follicle maturation 2/819 16/18670 0.154 0.3479 0.2668 MYO5A/TGFB2 2 BP GO:0051081 nuclear envelope disassembly 2/819 16/18670 0.154 0.3479 0.2668 PRKCA/PRKCB 2 BP GO:0051923 sulfation 2/819 16/18670 0.154 0.3479 0.2668 CHSY1/SULT1C2 2 BP GO:0060413 atrial septum morphogenesis 2/819 16/18670 0.154 0.3479 0.2668 TGFB2/SOX4 2 BP GO:0060572 morphogenesis of an epithelial bud 2/819 16/18670 0.154 0.3479 0.2668 BMP4/SULF1 2 BP GO:0061548 ganglion development 2/819 16/18670 0.154 0.3479 0.2668 NRP1/NRP2 2 BP GO:0071545 inositol phosphate catabolic process 2/819 16/18670 0.154 0.3479 0.2668 SYNJ2/INPP5E 2 BP GO:0072109 glomerular mesangium development 2/819 16/18670 0.154 0.3479 0.2668 BMP4/ACTA2 2 BP GO:0072176 nephric duct development 2/819 16/18670 0.154 0.3479 0.2668 BMP4/WNT11 2 BP GO:0090036 regulation of protein kinase C signaling 2/819 16/18670 0.154 0.3479 0.2668 GPD1L/WNT11 2 BP GO:0097067 cellular response to thyroid hormone stimulus 2/819 16/18670 0.154 0.3479 0.2668 LMO2/GCLM 2 BP GO:1990000 amyloid fibril formation 2/819 16/18670 0.154 0.3479 0.2668 CRYAB/GSN 2 BP GO:0002697 regulation of immune effector process 25/819 458/18670 0.1541 0.348 0.2669 MAPK3/CD55/THOC1/IL18R1/MICB/GRN/ANGPT1/IL12A/ITGB2/C1S/ABR/TNFRSF14/IFIT1/IL13RA2/RAPGEF1/TGFB2/ARRB2/C1R/RSAD2/SOCS5/IL4R/DNASE1L3/PHB/PKN1/HLX 25 BP GO:0002699 positive regulation of immune effector process 13/819 216/18670 0.1554 0.3509 0.2691 MAPK3/IL18R1/MICB/IL12A/ITGB2/TNFRSF14/IL13RA2/RAPGEF1/RSAD2/SOCS5/IL4R/PHB/HLX 13 BP GO:0051187 cofactor catabolic process 5/819 65/18670 0.1559 0.3518 0.2698 GGT5/PXDN/BLVRB/GPX3/CAT 5 BP GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 6/819 83/18670 0.1568 0.3537 0.2712 LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2 6 BP GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 8/819 120/18670 0.1572 0.3544 0.2718 CTSC/USP5/RAD23A/NUPR1/RNF144A/CAV3/SOCS5/RCHY1 8 BP GO:1901987 regulation of cell cycle phase transition 26/819 480/18670 0.1575 0.3544 0.2718 ESPL1/NACC2/PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/CCND2/PSMB6/PRMT1/KLF4/SYF2/BCL2/UBE2E1/PLCB1/PPP2R1A/ANAPC15/PSMD3/CKAP5/SOX4/IK/CTDSP2/PSMD2/PSMB8/CDKN2A/XPC 26 BP GO:0002831 regulation of response to biotic stimulus 9/819 139/18670 0.1576 0.3544 0.2718 MAPK3/CD55/PRKCA/MICB/GRN/IL12A/SASH1/IFIT1/UNC13B 9 BP GO:0046546 development of primary male sexual characteristics 9/819 139/18670 0.1576 0.3544 0.2718 GJA1/TGFBR1/NUPR1/ADAM15/BCL2L1/TGFB2/BCL2/EIF2S2/TMF1 9 BP GO:0070665 positive regulation of leukocyte proliferation 9/819 139/18670 0.1576 0.3544 0.2718 CD55/CD70/IL12A/CD24/BST1/IL6ST/BCL2/NCK1/HLA-DPB1 9 BP GO:0001774 microglial cell activation 4/819 48/18670 0.1583 0.3544 0.2718 CTSC/GRN/ITGB2/JAK2 4 BP GO:0002269 leukocyte activation involved in inflammatory response 4/819 48/18670 0.1583 0.3544 0.2718 CTSC/GRN/ITGB2/JAK2 4 BP GO:0007528 neuromuscular junction development 4/819 48/18670 0.1583 0.3544 0.2718 COL4A1/PDZRN3/UNC13B/TNC 4 BP GO:0007595 lactation 4/819 48/18670 0.1583 0.3544 0.2718 VDR/OAS2/GJA1/HIF1A 4 BP GO:0008038 neuron recognition 4/819 48/18670 0.1583 0.3544 0.2718 EPHB2/GAP43/PALLD/NRP1 4 BP GO:0008089 anterograde axonal transport 4/819 48/18670 0.1583 0.3544 0.2718 TRAK2/RAB27B/TERF2/MAP1A 4 BP GO:0009069 serine family amino acid metabolic process 4/819 48/18670 0.1583 0.3544 0.2718 SERINC5/GCLM/GART/MTHFD1 4 BP GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 4/819 48/18670 0.1583 0.3544 0.2718 BMP4/TGFBR1/INHBB/TGFB2 4 BP GO:0030850 prostate gland development 4/819 48/18670 0.1583 0.3544 0.2718 BMP4/FKBP4/SULF1/TNC 4 BP GO:0032648 regulation of interferon-beta production 4/819 48/18670 0.1583 0.3544 0.2718 POLR3D/POLR3G/IRF7/PTPN11 4 BP GO:0045912 negative regulation of carbohydrate metabolic process 4/819 48/18670 0.1583 0.3544 0.2718 ENPP1/NUPR1/FBP1/STAT3 4 BP GO:0060324 face development 4/819 48/18670 0.1583 0.3544 0.2718 MAPK3/COL1A1/ALDH1A3/PTPN11 4 BP GO:0090199 regulation of release of cytochrome c from mitochondria 4/819 48/18670 0.1583 0.3544 0.2718 HRK/BCL2L1/ARRB2/BAD 4 BP GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 7/819 102/18670 0.1607 0.3597 0.2759 DIRAS3/KAT2B/CNPPD1/CCND2/MAPRE3/HEXIM1/CDKN2A 7 BP GO:0032886 regulation of microtubule-based process 13/819 218/18670 0.1629 0.3627 0.2782 NSFL1C/KAT2B/CIB1/FKBP4/DIAPH1/MET/ARL2/MAPRE3/CAV3/CHMP2A/CLIP1/CAMSAP2/MAP1A 13 BP GO:0050807 regulation of synapse organization 13/819 218/18670 0.1629 0.3627 0.2782 TPBG/SPARC/EPHB2/IL1RAP/GAP43/NTRK2/ARF4/GPC4/ARHGEF15/GRIN2B/NRP2/FZD1/CAMK1 13 BP GO:0006513 protein monoubiquitination 5/819 66/18670 0.163 0.3627 0.2782 TRIM25/TSG101/UBE2E1/FBXL2/RYBP 5 BP GO:1904888 cranial skeletal system development 5/819 66/18670 0.163 0.3627 0.2782 BMP4/TGFBR1/TFAP2A/TGFB2/MTHFD1 5 BP GO:1905710 positive regulation of membrane permeability 5/819 66/18670 0.163 0.3627 0.2782 HIP1R/NMT1/BAD/BCL2/HEBP2 5 BP GO:0002718 regulation of cytokine production involved in immune response 6/819 84/18670 0.1631 0.3627 0.2782 MAPK3/IL18R1/ANGPT1/TNFRSF14/TGFB2/RSAD2 6 BP GO:0046889 positive regulation of lipid biosynthetic process 6/819 84/18670 0.1631 0.3627 0.2782 LPGAT1/ABCG1/NR1H2/NR1H3/MTOR/HTR2B 6 BP GO:0060420 regulation of heart growth 6/819 84/18670 0.1631 0.3627 0.2782 PIN1/GJA1/TGFBR1/CAV3/RGS2/MTOR 6 BP GO:0097756 negative regulation of blood vessel diameter 6/819 84/18670 0.1631 0.3627 0.2782 COMP/GJA1/HTR2B/EDNRA/ACTA2/PER2 6 BP GO:1905897 regulation of response to endoplasmic reticulum stress 6/819 84/18670 0.1631 0.3627 0.2782 PIK3R1/NUPR1/HSPA5/BCL2L1/UBE2J1/NCK1 6 BP GO:0001975 response to amphetamine 3/819 32/18670 0.1639 0.3627 0.2782 RGS2/ASIC1/GRIN2A 3 BP GO:0006356 regulation of transcription by RNA polymerase I 3/819 32/18670 0.1639 0.3627 0.2782 POLR2L/WDR43/MTOR 3 BP GO:0007616 long-term memory 3/819 32/18670 0.1639 0.3627 0.2782 CTNS/ADCY8/MTOR 3 BP GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/819 32/18670 0.1639 0.3627 0.2782 GSTO1/CLIC2/CACNA1C 3 BP GO:0015012 heparan sulfate proteoglycan biosynthetic process 3/819 32/18670 0.1639 0.3627 0.2782 NDST1/TCF7L2/EXT1 3 BP GO:0038128 ERBB2 signaling pathway 3/819 32/18670 0.1639 0.3627 0.2782 MYOC/PRKCA/PIK3R1 3 BP GO:0039694 viral RNA genome replication 3/819 32/18670 0.1639 0.3627 0.2782 APOBEC3C/RAB29/FBXL2 3 BP GO:0042744 hydrogen peroxide catabolic process 3/819 32/18670 0.1639 0.3627 0.2782 PXDN/GPX3/CAT 3 BP GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 3/819 32/18670 0.1639 0.3627 0.2782 PRKCA/FZD2/PHB 3 BP GO:0046685 response to arsenic-containing substance 3/819 32/18670 0.1639 0.3627 0.2782 GSTO1/UROS/TNFRSF11B 3 BP GO:0055022 negative regulation of cardiac muscle tissue growth 3/819 32/18670 0.1639 0.3627 0.2782 GJA1/CAV3/RGS2 3 BP GO:0055094 response to lipoprotein particle 3/819 32/18670 0.1639 0.3627 0.2782 ITGB2/SOCS5/ITGB1 3 BP GO:0061117 negative regulation of heart growth 3/819 32/18670 0.1639 0.3627 0.2782 GJA1/CAV3/RGS2 3 BP GO:0061384 heart trabecula morphogenesis 3/819 32/18670 0.1639 0.3627 0.2782 TGFBR1/CAV3/TGFB2 3 BP GO:0065005 protein-lipid complex assembly 3/819 32/18670 0.1639 0.3627 0.2782 BMP1/SH3GL2/BIN1 3 BP GO:0070570 regulation of neuron projection regeneration 3/819 32/18670 0.1639 0.3627 0.2782 GRN/THY1/KLF4 3 BP GO:0086019 cell-cell signaling involved in cardiac conduction 3/819 32/18670 0.1639 0.3627 0.2782 GJA1/GJC1/CACNA1C 3 BP GO:0099623 regulation of cardiac muscle cell membrane repolarization 3/819 32/18670 0.1639 0.3627 0.2782 GJA1/SNTA1/CAV3 3 BP GO:0002704 negative regulation of leukocyte mediated immunity 4/819 49/18670 0.1668 0.3686 0.2827 THOC1/ABR/IL13RA2/ARRB2 4 BP GO:0034260 negative regulation of GTPase activity 4/819 49/18670 0.1668 0.3686 0.2827 IQGAP1/ARL2/ARRB2/TMED2 4 BP GO:0071349 cellular response to interleukin-12 4/819 49/18670 0.1668 0.3686 0.2827 GSTO1/IL12A/JAK2/PLCB1 4 BP GO:0050709 negative regulation of protein secretion 9/819 141/18670 0.1672 0.3693 0.2832 IDH2/ANGPT1/NR1H3/INHBB/HADH/GAS6/RSAD2/PTPN11/EZR 9 BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 8/819 122/18670 0.1675 0.3698 0.2836 USP5/RAD23A/RNF144A/CLEC16A/SOCS5/MAP1A/RYBP/RCHY1 8 BP GO:0030900 forebrain development 21/819 381/18670 0.1681 0.3704 0.2841 COL3A1/SATB2/CXCL12/EPHB2/BMP4/LAMB1/NTRK2/TACC2/NRP1/HIF1A/ANXA3/GNG12/GART/UQCRQ/NOTCH3/EXT1/LPAR1/BAD/PLCB1/NRP2/ALDH1A3 21 BP GO:0045089 positive regulation of innate immune response 21/819 381/18670 0.1681 0.3704 0.2841 MAPKAPK3/PSMD8/PSMB7/MICB/PSMD1/IL12A/ITGB2/NR1H3/PIK3C3/POLR3D/XRCC6/PSMB6/POLR3G/ARRB2/RSAD2/HEXIM1/IRF7/PSMD3/PSMD2/PSMB8/CREBBP 21 BP GO:0050772 positive regulation of axonogenesis 6/819 85/18670 0.1694 0.3704 0.2841 CXCL12/NTRK2/PLXND1/NRP1/TWF2/PLXNC1 6 BP GO:0001675 acrosome assembly 2/819 17/18670 0.1697 0.3704 0.2841 AGFG1/TMF1 2 BP GO:0002031 G protein-coupled receptor internalization 2/819 17/18670 0.1697 0.3704 0.2841 ARRB2/HTR2B 2 BP GO:0002418 immune response to tumor cell 2/819 17/18670 0.1697 0.3704 0.2841 IL12A/ADAM15 2 BP GO:0003184 pulmonary valve morphogenesis 2/819 17/18670 0.1697 0.3704 0.2841 BMP4/TGFB2 2 BP GO:0006744 ubiquinone biosynthetic process 2/819 17/18670 0.1697 0.3704 0.2841 FDXR/COQ9 2 BP GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization 2/819 17/18670 0.1697 0.3704 0.2841 FOLR3/FOLR2 2 BP GO:0009070 serine family amino acid biosynthetic process 2/819 17/18670 0.1697 0.3704 0.2841 SERINC5/MTHFD1 2 BP GO:0014733 regulation of skeletal muscle adaptation 2/819 17/18670 0.1697 0.3704 0.2841 ATP2A2/MTOR 2 BP GO:0016254 preassembly of GPI anchor in ER membrane 2/819 17/18670 0.1697 0.3704 0.2841 PIGH/DPM2 2 BP GO:0018904 ether metabolic process 2/819 17/18670 0.1697 0.3704 0.2841 TXN/PEX7 2 BP GO:0035729 cellular response to hepatocyte growth factor stimulus 2/819 17/18670 0.1697 0.3704 0.2841 NRP1/GCLM 2 BP GO:0035988 chondrocyte proliferation 2/819 17/18670 0.1697 0.3704 0.2841 COMP/DDR2 2 BP GO:0043373 CD4-positive, alpha-beta T cell lineage commitment 2/819 17/18670 0.1697 0.3704 0.2841 STAT3/MTOR 2 BP GO:0050665 hydrogen peroxide biosynthetic process 2/819 17/18670 0.1697 0.3704 0.2841 CTNS/STAT3 2 BP GO:0051284 positive regulation of sequestering of calcium ion 2/819 17/18670 0.1697 0.3704 0.2841 GSTO1/CLIC2 2 BP GO:0055070 copper ion homeostasis 2/819 17/18670 0.1697 0.3704 0.2841 SLC31A2/ATOX1 2 BP GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 2/819 17/18670 0.1697 0.3704 0.2841 CACNA1C/BIN1 2 BP GO:0062033 positive regulation of mitotic sister chromatid segregation 2/819 17/18670 0.1697 0.3704 0.2841 ESPL1/SMC5 2 BP GO:0070242 thymocyte apoptotic process 2/819 17/18670 0.1697 0.3704 0.2841 BMP4/HIF1A 2 BP GO:0098884 postsynaptic neurotransmitter receptor internalization 2/819 17/18670 0.1697 0.3704 0.2841 ITGB3/AP2B1 2 BP GO:0140239 postsynaptic endocytosis 2/819 17/18670 0.1697 0.3704 0.2841 ITGB3/AP2B1 2 BP GO:1901663 quinone biosynthetic process 2/819 17/18670 0.1697 0.3704 0.2841 FDXR/COQ9 2 BP GO:1903209 positive regulation of oxidative stress-induced cell death 2/819 17/18670 0.1697 0.3704 0.2841 PAWR/FOXO3 2 BP GO:1905331 negative regulation of morphogenesis of an epithelium 2/819 17/18670 0.1697 0.3704 0.2841 BMP4/SULF1 2 BP GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2/819 17/18670 0.1697 0.3704 0.2841 GSN/JAK2 2 BP GO:0015807 L-amino acid transport 5/819 67/18670 0.1703 0.3716 0.285 CTNS/SLC7A8/SLC1A5/RGS2/PER2 5 BP GO:0009896 positive regulation of catabolic process 23/819 423/18670 0.1705 0.3719 0.2852 MAPK3/CTSC/USP5/RAD23A/ABHD5/GJA1/PRKD1/NUPR1/RNF144A/VPS11/TNRC6B/HIF1A/CLEC16A/PIK3CB/CAV3/PNPLA2/PTTG1IP/ZFP36/SOCS5/BAD/FOXO3/RCHY1/EZR 23 BP GO:0032412 regulation of ion transmembrane transporter activity 15/819 260/18670 0.1708 0.3724 0.2856 GSTO1/CLIC2/EPHB2/HSPA2/MYO5A/PDE4B/GNB5/ANXA3/CAV3/ATP1B1/STAC/GRIN2B/GPD1L/TRPC6/GRIN2A 15 BP GO:0030217 T cell differentiation 14/819 240/18670 0.1709 0.3724 0.2856 IL18R1/FZD7/BMP4/IL12A/STAT3/RSAD2/SOCS5/IL4R/MTOR/BAD/BCL2/TCIRG1/SOX4/HLX 14 BP GO:0050663 cytokine secretion 14/819 240/18670 0.1709 0.3724 0.2856 MAPK3/POSTN/IL1RAP/ISG15/ANGPT1/TNFRSF14/S100A13/GAS6/IL4R/TCIRG1/HTR2B/CHI3L1/SPTBN1/EZR 14 BP GO:0006470 protein dephosphorylation 18/819 321/18670 0.172 0.3746 0.2873 PPP1R7/PTPRA/PIN1/ITGA1/PTPRK/ANKLE2/JAK2/DUSP7/MTOR/BCL2/ENSA/PPP2R1A/PPP2R5D/PTPN11/CTDSP2/PHACTR4/PTPRB/NCK1 18 BP GO:0010675 regulation of cellular carbohydrate metabolic process 9/819 142/18670 0.1721 0.3746 0.2873 ENPP1/NUPR1/KAT2B/FBP1/STAT3/PDK1/MTOR/BAD/PDK2 9 BP GO:0006892 post-Golgi vesicle-mediated transport 7/819 104/18670 0.1722 0.3747 0.2873 SCAMP3/ARF4/GOSR2/MYO5A/KRT18/SPTBN1/VAMP3 7 BP GO:0006370 7-methylguanosine mRNA capping 3/819 33/18670 0.1749 0.3782 0.2901 POLR2L/POLR2E/CMTR1 3 BP GO:0010039 response to iron ion 3/819 33/18670 0.1749 0.3782 0.2901 TFAP2A/HIF1A/BCL2 3 BP GO:0010464 regulation of mesenchymal cell proliferation 3/819 33/18670 0.1749 0.3782 0.2901 BMP4/PDGFA/WNT11 3 BP GO:0010591 regulation of lamellipodium assembly 3/819 33/18670 0.1749 0.3782 0.2901 TWF2/FSCN1/MTOR 3 BP GO:0016242 negative regulation of macroautophagy 3/819 33/18670 0.1749 0.3782 0.2901 NUPR1/CLEC16A/MTOR 3 BP GO:0019934 cGMP-mediated signaling 3/819 33/18670 0.1749 0.3782 0.2901 THBS1/RUNDC3A/HTR2B 3 BP GO:0030513 positive regulation of BMP signaling pathway 3/819 33/18670 0.1749 0.3782 0.2901 BMP4/SULF1/ZNF423 3 BP GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 3/819 33/18670 0.1749 0.3782 0.2901 HSPA5/HIF1A/HSF4 3 BP GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3/819 33/18670 0.1749 0.3782 0.2901 EXOSC7/EXOSC2/LSM4 3 BP GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 3/819 33/18670 0.1749 0.3782 0.2901 KAT2B/HEXIM1/CDKN2A 3 BP GO:0051204 protein insertion into mitochondrial membrane 3/819 33/18670 0.1749 0.3782 0.2901 NMT1/BAD/BCL2 3 BP GO:0051955 regulation of amino acid transport 3/819 33/18670 0.1749 0.3782 0.2901 SV2A/RGS2/PER2 3 BP GO:0060603 mammary gland duct morphogenesis 3/819 33/18670 0.1749 0.3782 0.2901 VDR/KDM5B/CAV3 3 BP GO:0071985 multivesicular body sorting pathway 3/819 33/18670 0.1749 0.3782 0.2901 RAB27B/LYST/CHMP2A 3 BP GO:1901797 negative regulation of signal transduction by p53 class mediator 3/819 33/18670 0.1749 0.3782 0.2901 SNAI2/PTTG1IP/BCL2 3 BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 4/819 50/18670 0.1755 0.3784 0.2902 HIF1A/GAS6/IRF7/AGPAT1 4 BP GO:0032608 interferon-beta production 4/819 50/18670 0.1755 0.3784 0.2902 POLR3D/POLR3G/IRF7/PTPN11 4 BP GO:0032784 regulation of DNA-templated transcription, elongation 4/819 50/18670 0.1755 0.3784 0.2902 THOC1/HMGN1/SUPT4H1/HTATSF1 4 BP GO:0045540 regulation of cholesterol biosynthetic process 4/819 50/18670 0.1755 0.3784 0.2902 TM7SF2/ABCG1/MBTPS1/NFYB 4 BP GO:0060425 lung morphogenesis 4/819 50/18670 0.1755 0.3784 0.2902 MAPK3/BMP4/LAMA1/TNC 4 BP GO:0070671 response to interleukin-12 4/819 50/18670 0.1755 0.3784 0.2902 GSTO1/IL12A/JAK2/PLCB1 4 BP GO:0072698 protein localization to microtubule cytoskeleton 4/819 50/18670 0.1755 0.3784 0.2902 NSFL1C/DIAPH1/MAPRE3/MAP1A 4 BP GO:0106118 regulation of sterol biosynthetic process 4/819 50/18670 0.1755 0.3784 0.2902 TM7SF2/ABCG1/MBTPS1/NFYB 4 BP GO:0030101 natural killer cell activation 6/819 86/18670 0.1759 0.3788 0.2905 IL18R1/MICB/IL12A/ITGB2/SNX27/GAS6 6 BP GO:0042446 hormone biosynthetic process 6/819 86/18670 0.1759 0.3788 0.2905 VDR/STC2/FDXR/CYP3A4/CYP27A1/HIF1A 6 BP GO:0060291 long-term synaptic potentiation 6/819 86/18670 0.1759 0.3788 0.2905 ADCY8/EPHB2/NTRK2/ITPR3/GRIN2B/GRIN2A 6 BP GO:0052548 regulation of endopeptidase activity 23/819 425/18670 0.1761 0.3791 0.2907 RENBP/HIP1R/CRYAB/SIAH2/THBS1/SERPINH1/LAMTOR5/MAP3K5/COL6A3/GSN/COL7A1/SERPINB6/STAT3/ARRB2/KLF4/JAK2/GAS6/GRIN2B/BAD/BIN1/CASP9/PSMB8/GRIN2A 23 BP GO:0009566 fertilization 11/819 182/18670 0.177 0.3808 0.292 KDM5B/FOLR3/FOLR2/BCL2L1/SPA17/GLRB/GNPDA1/UNC13B/CCT7/PLCB1/TRPC6 11 BP GO:0030879 mammary gland development 9/819 143/18670 0.177 0.3808 0.292 VDR/KDM5B/BMP4/OAS2/GJA1/HIF1A/CAV3/JAK2/ITGA2 9 BP GO:0033866 nucleoside bisphosphate biosynthetic process 5/819 68/18670 0.1777 0.3816 0.2927 ELOVL2/PDK1/TECR/COASY/PDK2 5 BP GO:0034030 ribonucleoside bisphosphate biosynthetic process 5/819 68/18670 0.1777 0.3816 0.2927 ELOVL2/PDK1/TECR/COASY/PDK2 5 BP GO:0034033 purine nucleoside bisphosphate biosynthetic process 5/819 68/18670 0.1777 0.3816 0.2927 ELOVL2/PDK1/TECR/COASY/PDK2 5 BP GO:0050891 multicellular organismal water homeostasis 5/819 68/18670 0.1777 0.3816 0.2927 ADCY8/CLDN4/ADCY7/MET/HAS2 5 BP GO:0006637 acyl-CoA metabolic process 7/819 105/18670 0.178 0.3819 0.2929 ACOT13/HMGCL/OGDH/ELOVL2/PDK1/TECR/PDK2 7 BP GO:0032006 regulation of TOR signaling 7/819 105/18670 0.178 0.3819 0.2929 ARNTL/RRAGD/LAMTOR5/HIF1A/CLEC16A/GAS6/SEC13 7 BP GO:0035383 thioester metabolic process 7/819 105/18670 0.178 0.3819 0.2929 ACOT13/HMGCL/OGDH/ELOVL2/PDK1/TECR/PDK2 7 BP GO:0019218 regulation of steroid metabolic process 8/819 124/18670 0.1782 0.382 0.293 VDR/TM7SF2/IGFBP7/ABCG1/SNAI2/ASAH1/MBTPS1/NFYB 8 BP GO:0099173 postsynapse organization 10/819 163/18670 0.1798 0.3853 0.2955 ACTN1/EPHB2/IL1RAP/GAP43/ARF4/NRP1/ITGA3/GLRB/GRIN2B/NRP2 10 BP GO:0061136 regulation of proteasomal protein catabolic process 11/819 183/18670 0.1814 0.3887 0.2981 USP5/RAD23A/NUPR1/RNF144A/CLEC16A/UBE2J1/SOCS5/MAP1A/RYBP/RCHY1/TMF1 11 BP GO:0002456 T cell mediated immunity 7/819 106/18670 0.184 0.3925 0.3011 CD55/IL18R1/CTSC/MICB/CD70/IL12A/RSAD2 7 BP GO:0042136 neurotransmitter biosynthetic process 7/819 106/18670 0.184 0.3925 0.3011 CYP1B1/DDAH2/ITGB2/KLF4/JAK2/MTOR/PTX3 7 BP GO:0051963 regulation of synapse assembly 7/819 106/18670 0.184 0.3925 0.3011 TPBG/EPHB2/IL1RAP/GAP43/NTRK2/GPC4/FZD1 7 BP GO:1904029 regulation of cyclin-dependent protein kinase activity 7/819 106/18670 0.184 0.3925 0.3011 DIRAS3/KAT2B/CNPPD1/CCND2/MAPRE3/HEXIM1/CDKN2A 7 BP GO:0007566 embryo implantation 4/819 51/18670 0.1843 0.3925 0.3011 PCSK5/IGFBP7/STC2/FKBP4 4 BP GO:0009994 oocyte differentiation 4/819 51/18670 0.1843 0.3925 0.3011 INHBB/BCL2/PPP2R1A/FOXO3 4 BP GO:0032206 positive regulation of telomere maintenance 4/819 51/18670 0.1843 0.3925 0.3011 MAPK3/MAP3K4/NEK7/CCT7 4 BP GO:2001258 negative regulation of cation channel activity 4/819 51/18670 0.1843 0.3925 0.3011 GSTO1/CLIC2/EPHB2/GNB5 4 BP GO:0006633 fatty acid biosynthetic process 10/819 164/18670 0.1845 0.3925 0.3011 LPGAT1/ELOVL2/NR1H2/NDUFAB1/NR1H3/PLP1/CYP3A4/MYO5A/GPX4/TECR 10 BP GO:0055008 cardiac muscle tissue morphogenesis 5/819 69/18670 0.1852 0.3925 0.3011 COL11A1/TGFBR1/FOXC1/TPM1/TGFB2 5 BP GO:0006743 ubiquinone metabolic process 2/819 18/18670 0.1856 0.3925 0.3011 FDXR/COQ9 2 BP GO:0007250 activation of NF-kappaB-inducing kinase activity 2/819 18/18670 0.1856 0.3925 0.3011 COPS8/CHI3L1 2 BP GO:0034199 activation of protein kinase A activity 2/819 18/18670 0.1856 0.3925 0.3011 ADCY8/ADCY7 2 BP GO:0034375 high-density lipoprotein particle remodeling 2/819 18/18670 0.1856 0.3925 0.3011 ABCG1/PLTP 2 BP GO:0044320 cellular response to leptin stimulus 2/819 18/18670 0.1856 0.3925 0.3011 INHBB/STAT3 2 BP GO:0045653 negative regulation of megakaryocyte differentiation 2/819 18/18670 0.1856 0.3925 0.3011 CIB1/PRMT1 2 BP GO:0045780 positive regulation of bone resorption 2/819 18/18670 0.1856 0.3925 0.3011 PLEKHM1/PRKCA 2 BP GO:0046852 positive regulation of bone remodeling 2/819 18/18670 0.1856 0.3925 0.3011 PLEKHM1/PRKCA 2 BP GO:0048339 paraxial mesoderm development 2/819 18/18670 0.1856 0.3925 0.3011 FOXC1/WNT11 2 BP GO:0051895 negative regulation of focal adhesion assembly 2/819 18/18670 0.1856 0.3925 0.3011 THBS1/ITGB1BP1 2 BP GO:0060977 coronary vasculature morphogenesis 2/819 18/18670 0.1856 0.3925 0.3011 TGFBR1/NRP1 2 BP GO:0070233 negative regulation of T cell apoptotic process 2/819 18/18670 0.1856 0.3925 0.3011 BMP4/HIF1A 2 BP GO:0090026 positive regulation of monocyte chemotaxis 2/819 18/18670 0.1856 0.3925 0.3011 CXCL12/CCR1 2 BP GO:0090196 regulation of chemokine secretion 2/819 18/18670 0.1856 0.3925 0.3011 POSTN/IL4R 2 BP GO:0150078 positive regulation of neuroinflammatory response 2/819 18/18670 0.1856 0.3925 0.3011 CTSC/NUPR1 2 BP GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/819 18/18670 0.1856 0.3925 0.3011 TNRC6B/ZFP36 2 BP GO:1903019 negative regulation of glycoprotein metabolic process 2/819 18/18670 0.1856 0.3925 0.3011 ITM2B/PTX3 2 BP GO:1904872 regulation of telomerase RNA localization to Cajal body 2/819 18/18670 0.1856 0.3925 0.3011 NHP2/CCT7 2 BP GO:0043401 steroid hormone mediated signaling pathway 11/819 184/18670 0.1859 0.3925 0.3011 VDR/ARNTL/BMP4/NR1H2/NR1H3/FKBP4/WBP2/ARRB2/JAK2/STRN3/PHB 11 BP GO:0048639 positive regulation of developmental growth 11/819 184/18670 0.1859 0.3925 0.3011 PIN1/CXCL12/GHR/NRP1/TWF2/PPIB/MTOR/BCL2/PLCB1/EZR/HLX 11 BP GO:0003382 epithelial cell morphogenesis 3/819 34/18670 0.1859 0.3925 0.3011 PALLD/MET/FLNB 3 BP GO:0009452 7-methylguanosine RNA capping 3/819 34/18670 0.1859 0.3925 0.3011 POLR2L/POLR2E/CMTR1 3 BP GO:0036260 RNA capping 3/819 34/18670 0.1859 0.3925 0.3011 POLR2L/POLR2E/CMTR1 3 BP GO:0042533 tumor necrosis factor biosynthetic process 3/819 34/18670 0.1859 0.3925 0.3011 THBS1/UBE2J1/JAK2 3 BP GO:0042534 regulation of tumor necrosis factor biosynthetic process 3/819 34/18670 0.1859 0.3925 0.3011 THBS1/UBE2J1/JAK2 3 BP GO:0043368 positive T cell selection 3/819 34/18670 0.1859 0.3925 0.3011 STAT3/MTOR/BCL2 3 BP GO:0060795 cell fate commitment involved in formation of primary germ layer 3/819 34/18670 0.1859 0.3925 0.3011 FZD7/BMP4/KLF4 3 BP GO:1904030 negative regulation of cyclin-dependent protein kinase activity 3/819 34/18670 0.1859 0.3925 0.3011 KAT2B/HEXIM1/CDKN2A 3 BP GO:0006473 protein acetylation 12/819 204/18670 0.1865 0.3935 0.3018 MAPK3/ARNTL/NUPR1/KAT2B/POLE3/SNAI2/WBP2/JADE2/SOX4/MDH2/CREBBP/CAMK1 12 BP GO:0071901 negative regulation of protein serine/threonine kinase activity 9/819 145/18670 0.1871 0.3947 0.3027 BMP4/KAT2B/CIB1/CAV3/RGS2/DUSP7/HEXIM1/PPP2R1A/CDKN2A 9 BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8/819 126/18670 0.1891 0.3983 0.3054 GREM1/LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2/FZD1 8 BP GO:0022404 molting cycle process 6/819 88/18670 0.1891 0.3983 0.3054 LRIG1/MYO5A/FZD6/PDGFA/TGFB2/BCL2 6 BP GO:0022405 hair cycle process 6/819 88/18670 0.1891 0.3983 0.3054 LRIG1/MYO5A/FZD6/PDGFA/TGFB2/BCL2 6 BP GO:0061097 regulation of protein tyrosine kinase activity 6/819 88/18670 0.1891 0.3983 0.3054 NTRK2/CD24/THY1/GAS6/SOCS5/TSG101 6 BP GO:0048638 regulation of developmental growth 19/819 347/18670 0.1899 0.3998 0.3066 STC2/PIN1/CXCL12/BMP4/GJA1/TGFBR1/FOXC1/GHR/NRP1/TWF2/PPIB/CAV3/STAT3/RGS2/MTOR/BCL2/PLCB1/EZR/HLX 19 BP GO:0098781 ncRNA transcription 7/819 107/18670 0.19 0.3998 0.3066 POLR2L/POLR2E/USPL1/SNAPC4/ELL2/MTOR/SNAPC5 7 BP GO:0045665 negative regulation of neuron differentiation 13/819 225/18670 0.1906 0.401 0.3075 TRAK2/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/THY1/NOTCH3/PMP22/LPAR1/RAB29/TRPC6/FOXO3 13 BP GO:0045834 positive regulation of lipid metabolic process 9/819 146/18670 0.1923 0.4038 0.3097 LPGAT1/ABCG1/ABHD5/PRKD1/NR1H2/NR1H3/PNPLA2/MTOR/HTR2B 9 BP GO:0051250 negative regulation of lymphocyte activation 9/819 146/18670 0.1923 0.4038 0.3097 THOC1/BMP4/TNFRSF14/SOCS5/IL4R/PAWR/SDC4/PKN1/HLX 9 BP GO:0051384 response to glucocorticoid 9/819 146/18670 0.1923 0.4038 0.3097 IGFBP7/ABCA3/SPARC/ANXA3/ZFP36/BAD/BCL2/CASP9/FOXO3 9 BP GO:1904892 regulation of STAT cascade 9/819 146/18670 0.1923 0.4038 0.3097 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/IL6ST/SOCS3/PPP2R1A 9 BP GO:0050766 positive regulation of phagocytosis 5/819 70/18670 0.1928 0.4048 0.3104 ABR/RAPGEF1/GAS6/ITGA2/PTX3 5 BP GO:0050885 neuromuscular process controlling balance 4/819 52/18670 0.1933 0.4055 0.311 CLN3/GM2A/ABR/ALDH1A3 4 BP GO:0099518 vesicle cytoskeletal trafficking 4/819 52/18670 0.1933 0.4055 0.311 TRAK2/CLN3/MYO5A/DYNC1I1 4 BP GO:0090288 negative regulation of cellular response to growth factor stimulus 10/819 166/18670 0.1941 0.4069 0.312 GREM1/THBS1/LTBP1/PIN1/EMILIN1/TGFBR1/HSPA5/FBN2/SULF1/FZD1 10 BP GO:0097696 STAT cascade 10/819 166/18670 0.1941 0.4069 0.312 CRLF1/CYP1B1/IL12A/GHR/STAT3/JAK2/SOCS5/IL6ST/SOCS3/PPP2R1A 10 BP GO:0035270 endocrine system development 8/819 127/18670 0.1947 0.4077 0.3127 MAPK3/ARNTL/RFX3/BMP4/TGFBR1/WNT11/BAD/SOX4 8 BP GO:0099024 plasma membrane invagination 8/819 127/18670 0.1947 0.4077 0.3127 THBS1/ITGB2/MYH9/GULP1/GSN/IGLL1/ITGA2/RHOBTB2 8 BP GO:0032602 chemokine production 6/819 89/18670 0.1958 0.4094 0.3139 POSTN/SNAI2/HIF1A/KLF4/SOCS5/IL4R 6 BP GO:0061053 somite development 6/819 89/18670 0.1958 0.4094 0.3139 FOXC1/WNT11/MTHFD1/ROR2/KDM6A/TMED2 6 BP GO:0006821 chloride transport 7/819 108/18670 0.1961 0.4094 0.3139 CLIC2/CLIC1/CLDN4/CLCN7/GLRB/CLCN6/CLIC5 7 BP GO:0009895 negative regulation of catabolic process 17/819 308/18670 0.1971 0.4094 0.3139 CTSA/PIN1/NUPR1/HNRNPA0/FBP1/MET/CLEC16A/UBE2J1/STAT3/ZFP36/MTOR/BCL2/HTR2B/MAP1A/PHB/RYBP/GRIN2A 17 BP GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 3/819 35/18670 0.1972 0.4094 0.3139 EXOSC7/EXOSC2/LSM4 3 BP GO:0003203 endocardial cushion morphogenesis 3/819 35/18670 0.1972 0.4094 0.3139 TGFBR1/SNAI2/TGFB2 3 BP GO:0009262 deoxyribonucleotide metabolic process 3/819 35/18670 0.1972 0.4094 0.3139 MBD4/GUK1/RRM2 3 BP GO:0010259 multicellular organism aging 3/819 35/18670 0.1972 0.4094 0.3139 CRYAB/COMP/NDUFS6 3 BP GO:0019076 viral release from host cell 3/819 35/18670 0.1972 0.4094 0.3139 TRIM25/CHMP2A/TSG101 3 BP GO:0021955 central nervous system neuron axonogenesis 3/819 35/18670 0.1972 0.4094 0.3139 CDH11/EPHB2/ADARB1 3 BP GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 3/819 35/18670 0.1972 0.4094 0.3139 CLEC16A/MAP1A/RYBP 3 BP GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway 3/819 35/18670 0.1972 0.4094 0.3139 ARNTL/STRN3/PHB 3 BP GO:0033363 secretory granule organization 3/819 35/18670 0.1972 0.4094 0.3139 LYST/AGFG1/TMF1 3 BP GO:0035890 exit from host 3/819 35/18670 0.1972 0.4094 0.3139 TRIM25/CHMP2A/TSG101 3 BP GO:0035891 exit from host cell 3/819 35/18670 0.1972 0.4094 0.3139 TRIM25/CHMP2A/TSG101 3 BP GO:0042455 ribonucleoside biosynthetic process 3/819 35/18670 0.1972 0.4094 0.3139 NME3/GUK1/CTPS1 3 BP GO:0045622 regulation of T-helper cell differentiation 3/819 35/18670 0.1972 0.4094 0.3139 SOCS5/IL4R/HLX 3 BP GO:0046466 membrane lipid catabolic process 3/819 35/18670 0.1972 0.4094 0.3139 CYP1B1/GM2A/ASAH1 3 BP GO:0052126 movement in host environment 3/819 35/18670 0.1972 0.4094 0.3139 TRIM25/CHMP2A/TSG101 3 BP GO:0052192 movement in environment of other organism involved in symbiotic interaction 3/819 35/18670 0.1972 0.4094 0.3139 TRIM25/CHMP2A/TSG101 3 BP GO:0060338 regulation of type I interferon-mediated signaling pathway 3/819 35/18670 0.1972 0.4094 0.3139 ADAR/IRF7/PTPN11 3 BP GO:1901385 regulation of voltage-gated calcium channel activity 3/819 35/18670 0.1972 0.4094 0.3139 PDE4B/GNB5/STAC 3 BP GO:1903539 protein localization to postsynaptic membrane 3/819 35/18670 0.1972 0.4094 0.3139 GPC4/RAB8A/GRIN2A 3 BP GO:1905332 positive regulation of morphogenesis of an epithelium 3/819 35/18670 0.1972 0.4094 0.3139 MAGED1/BMP4/MTOR 3 BP GO:0000086 G2/M transition of mitotic cell cycle 14/819 247/18670 0.1979 0.4107 0.315 PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/PSMB6/SYF2/ENSA/PLCB1/PPP2R1A/PSMD3/CKAP5/PSMD2/PSMB8 14 BP GO:0050803 regulation of synapse structure or activity 13/819 227/18670 0.1989 0.4125 0.3164 TPBG/SPARC/EPHB2/IL1RAP/GAP43/NTRK2/ARF4/GPC4/ARHGEF15/GRIN2B/NRP2/FZD1/CAMK1 13 BP GO:0099003 vesicle-mediated transport in synapse 12/819 207/18670 0.1995 0.4132 0.3169 SH3GL2/ATP2A2/SV2A/RAB27B/KIAA1107/ITGB3/NAPA/SPG11/PRKCB/RAB8A/UNC13B/AP2B1 12 BP GO:0009855 determination of bilateral symmetry 8/819 128/18670 0.2003 0.4132 0.3169 GREM1/PCSK5/MICAL2/RFX3/GJA1/BICC1/HIF1A/TMED2 8 BP GO:0042795 snRNA transcription by RNA polymerase II 5/819 71/18670 0.2005 0.4132 0.3169 POLR2L/POLR2E/SNAPC4/ELL2/SNAPC5 5 BP GO:0001573 ganglioside metabolic process 2/819 19/18670 0.2018 0.4132 0.3169 ST3GAL5/GM2A 2 BP GO:0001710 mesodermal cell fate commitment 2/819 19/18670 0.2018 0.4132 0.3169 BMP4/KLF4 2 BP GO:0002544 chronic inflammatory response 2/819 19/18670 0.2018 0.4132 0.3169 THBS1/GJA1 2 BP GO:0002726 positive regulation of T cell cytokine production 2/819 19/18670 0.2018 0.4132 0.3169 IL18R1/RSAD2 2 BP GO:0006337 nucleosome disassembly 2/819 19/18670 0.2018 0.4132 0.3169 SMARCE1/HMGA1 2 BP GO:0007350 blastoderm segmentation 2/819 19/18670 0.2018 0.4132 0.3169 NRP1/NRP2 2 BP GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process 2/819 19/18670 0.2018 0.4132 0.3169 NME3/CTPS1 2 BP GO:0016048 detection of temperature stimulus 2/819 19/18670 0.2018 0.4132 0.3169 CXCL12/ARRB2 2 BP GO:0016074 snoRNA metabolic process 2/819 19/18670 0.2018 0.4132 0.3169 NOLC1/EXOSC2 2 BP GO:0016075 rRNA catabolic process 2/819 19/18670 0.2018 0.4132 0.3169 EXOSC7/EXOSC2 2 BP GO:0030859 polarized epithelial cell differentiation 2/819 19/18670 0.2018 0.4132 0.3169 PTK7/LAMA1 2 BP GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 2/819 19/18670 0.2018 0.4132 0.3169 ELOVL2/TECR 2 BP GO:0035728 response to hepatocyte growth factor 2/819 19/18670 0.2018 0.4132 0.3169 NRP1/GCLM 2 BP GO:0036303 lymph vessel morphogenesis 2/819 19/18670 0.2018 0.4132 0.3169 FOXC1/VEGFC 2 BP GO:0048025 negative regulation of mRNA splicing, via spliceosome 2/819 19/18670 0.2018 0.4132 0.3169 SAP18/SRSF7 2 BP GO:0051546 keratinocyte migration 2/819 19/18670 0.2018 0.4132 0.3169 HAS2/MTOR 2 BP GO:0060231 mesenchymal to epithelial transition 2/819 19/18670 0.2018 0.4132 0.3169 FZD7/BMP4 2 BP GO:0060438 trachea development 2/819 19/18670 0.2018 0.4132 0.3169 MAPK3/BMP4 2 BP GO:0060973 cell migration involved in heart development 2/819 19/18670 0.2018 0.4132 0.3169 BMP4/SNAI2 2 BP GO:0071071 regulation of phospholipid biosynthetic process 2/819 19/18670 0.2018 0.4132 0.3169 PDGFA/HTR2B 2 BP GO:0071243 cellular response to arsenic-containing substance 2/819 19/18670 0.2018 0.4132 0.3169 GSTO1/UROS 2 BP GO:0071800 podosome assembly 2/819 19/18670 0.2018 0.4132 0.3169 GSN/FSCN1 2 BP GO:0090201 negative regulation of release of cytochrome c from mitochondria 2/819 19/18670 0.2018 0.4132 0.3169 BCL2L1/ARRB2 2 BP GO:0090670 RNA localization to Cajal body 2/819 19/18670 0.2018 0.4132 0.3169 NHP2/CCT7 2 BP GO:0090671 telomerase RNA localization to Cajal body 2/819 19/18670 0.2018 0.4132 0.3169 NHP2/CCT7 2 BP GO:0090672 telomerase RNA localization 2/819 19/18670 0.2018 0.4132 0.3169 NHP2/CCT7 2 BP GO:0090685 RNA localization to nucleus 2/819 19/18670 0.2018 0.4132 0.3169 NHP2/CCT7 2 BP GO:0098911 regulation of ventricular cardiac muscle cell action potential 2/819 19/18670 0.2018 0.4132 0.3169 CACNA1C/BIN1 2 BP GO:1900409 positive regulation of cellular response to oxidative stress 2/819 19/18670 0.2018 0.4132 0.3169 PAWR/FOXO3 2 BP GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/819 19/18670 0.2018 0.4132 0.3169 HIF1A/TRAP1 2 BP GO:2000251 positive regulation of actin cytoskeleton reorganization 2/819 19/18670 0.2018 0.4132 0.3169 NRP1/HAX1 2 BP GO:0043543 protein acylation 14/819 248/18670 0.202 0.4132 0.3169 MAPK3/ARNTL/OGDH/NUPR1/KAT2B/POLE3/SNAI2/WBP2/NMT1/JADE2/SOX4/MDH2/CREBBP/CAMK1 14 BP GO:0021879 forebrain neuron differentiation 4/819 53/18670 0.2024 0.4132 0.3169 SATB2/NRP1/UQCRQ/NRP2 4 BP GO:0031122 cytoplasmic microtubule organization 4/819 53/18670 0.2024 0.4132 0.3169 CIB1/CAV3/CAMSAP2/EZR 4 BP GO:0031638 zymogen activation 4/819 53/18670 0.2024 0.4132 0.3169 THBS1/C1R/BAD/GRIN2A 4 BP GO:0035036 sperm-egg recognition 4/819 53/18670 0.2024 0.4132 0.3169 FOLR3/FOLR2/SPA17/CCT7 4 BP GO:0045214 sarcomere organization 4/819 53/18670 0.2024 0.4132 0.3169 TPM1/CSRP2/CAV3/ITGB1 4 BP GO:1902475 L-alpha-amino acid transmembrane transport 4/819 53/18670 0.2024 0.4132 0.3169 SLC7A8/SLC1A5/RGS2/PER2 4 BP GO:0042475 odontogenesis of dentin-containing tooth 6/819 90/18670 0.2027 0.4136 0.3172 BMP4/FOXC1/ITGA6/TNFRSF11B/TNC/TCIRG1 6 BP GO:0002792 negative regulation of peptide secretion 9/819 148/18670 0.2027 0.4136 0.3172 IDH2/ANGPT1/NR1H3/INHBB/HADH/GAS6/RSAD2/PTPN11/EZR 9 BP GO:0006639 acylglycerol metabolic process 8/819 129/18670 0.206 0.4202 0.3222 SEL1L/ABHD5/NR1H2/NR1H3/CAV3/PNPLA2/CAT/PTPN11 8 BP GO:0014074 response to purine-containing compound 9/819 149/18670 0.208 0.4234 0.3247 SPARC/COL1A1/HSPA5/LDHA/TYR/RAPGEF1/CNGA3/P2RY2/EZR 9 BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 9/819 149/18670 0.208 0.4234 0.3247 USP5/RAD23A/RNF144A/CLEC16A/CAV3/SOCS5/MAP1A/RYBP/RCHY1 9 BP GO:0035019 somatic stem cell population maintenance 5/819 72/18670 0.2083 0.4234 0.3247 POLR2L/POLR2E/STAT3/KLF4/SOX4 5 BP GO:0061180 mammary gland epithelium development 5/819 72/18670 0.2083 0.4234 0.3247 VDR/KDM5B/HIF1A/CAV3/JAK2 5 BP GO:0003091 renal water homeostasis 3/819 36/18670 0.2087 0.4234 0.3247 ADCY8/ADCY7/HAS2 3 BP GO:0006361 transcription initiation from RNA polymerase I promoter 3/819 36/18670 0.2087 0.4234 0.3247 MAPK3/POLR2L/POLR2E 3 BP GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 3/819 36/18670 0.2087 0.4234 0.3247 GSTO1/CLIC2/CACNA1C 3 BP GO:0030224 monocyte differentiation 3/819 36/18670 0.2087 0.4234 0.3247 BMP4/MYH9/IRF7 3 BP GO:0033762 response to glucagon 3/819 36/18670 0.2087 0.4234 0.3247 ADCY8/ADCY7/QDPR 3 BP GO:0034314 Arp2/3 complex-mediated actin nucleation 3/819 36/18670 0.2087 0.4234 0.3247 HIP1R/ARPC1B/GMFG 3 BP GO:0071709 membrane assembly 3/819 36/18670 0.2087 0.4234 0.3247 EPHB2/CAV3/SPTBN1 3 BP GO:0090322 regulation of superoxide metabolic process 3/819 36/18670 0.2087 0.4234 0.3247 ITGB2/BST1/FBLN5 3 BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 3/819 36/18670 0.2087 0.4234 0.3247 GSTO1/CLIC2/GNB5 3 BP GO:1903131 mononuclear cell differentiation 3/819 36/18670 0.2087 0.4234 0.3247 BMP4/MYH9/IRF7 3 BP GO:0071383 cellular response to steroid hormone stimulus 14/819 250/18670 0.2101 0.4261 0.3268 VDR/ARNTL/BMP4/NR1H2/NR1H3/FKBP4/WBP2/ARRB2/JAK2/ZFP36/STRN3/PHB/CASP9/FOXO3 14 BP GO:0002720 positive regulation of cytokine production involved in immune response 4/819 54/18670 0.2116 0.4269 0.3274 MAPK3/IL18R1/TNFRSF14/RSAD2 4 BP GO:0002763 positive regulation of myeloid leukocyte differentiation 4/819 54/18670 0.2116 0.4269 0.3274 PRKCA/HAX1/CCR1/ROR2 4 BP GO:0006584 catecholamine metabolic process 4/819 54/18670 0.2116 0.4269 0.3274 ITGB2/EPAS1/TGFB2/GRIN2A 4 BP GO:0009066 aspartate family amino acid metabolic process 4/819 54/18670 0.2116 0.4269 0.3274 OGDH/MTHFD1/ALDH7A1/CRYM 4 BP GO:0009712 catechol-containing compound metabolic process 4/819 54/18670 0.2116 0.4269 0.3274 ITGB2/EPAS1/TGFB2/GRIN2A 4 BP GO:0032655 regulation of interleukin-12 production 4/819 54/18670 0.2116 0.4269 0.3274 THBS1/MAST2/ARRB2/PLCB1 4 BP GO:0032663 regulation of interleukin-2 production 4/819 54/18670 0.2116 0.4269 0.3274 PDE4B/ZFP36/SPTBN1/EZR 4 BP GO:0035384 thioester biosynthetic process 4/819 54/18670 0.2116 0.4269 0.3274 ELOVL2/PDK1/TECR/PDK2 4 BP GO:0050994 regulation of lipid catabolic process 4/819 54/18670 0.2116 0.4269 0.3274 RARRES2/ABHD5/PNPLA2/MTOR 4 BP GO:0051353 positive regulation of oxidoreductase activity 4/819 54/18670 0.2116 0.4269 0.3274 VDR/HIF1A/TERF2/HTR2B 4 BP GO:0061512 protein localization to cilium 4/819 54/18670 0.2116 0.4269 0.3274 ARF4/RAB29/INPP5E/ATP6V1D 4 BP GO:0071616 acyl-CoA biosynthetic process 4/819 54/18670 0.2116 0.4269 0.3274 ELOVL2/PDK1/TECR/PDK2 4 BP GO:0097345 mitochondrial outer membrane permeabilization 4/819 54/18670 0.2116 0.4269 0.3274 HIP1R/NMT1/BAD/BCL2 4 BP GO:1900047 negative regulation of hemostasis 4/819 54/18670 0.2116 0.4269 0.3274 THBS1/COMP/FAP/PDGFA 4 BP GO:0006638 neutral lipid metabolic process 8/819 130/18670 0.2118 0.4271 0.3276 SEL1L/ABHD5/NR1H2/NR1H3/CAV3/PNPLA2/CAT/PTPN11 8 BP GO:0007163 establishment or maintenance of cell polarity 12/819 210/18670 0.2129 0.4292 0.3292 PTK7/NSFL1C/ARF4/MYH9/GSN/FSCN1/SNX27/LAMA1/WNT11/CYTH1/KIF2C/CKAP5 12 BP GO:0043433 negative regulation of DNA-binding transcription factor activity 10/819 170/18670 0.2139 0.4309 0.3304 SFRP4/CYP1B1/TCF7L2/NUPR1/FZD6/ARRB2/KLF4/GAS6/CAT/CDKN2A 10 BP GO:0071772 response to BMP 10/819 170/18670 0.2139 0.4309 0.3304 MAPK3/SFRP4/GREM1/COMP/BMP4/ITGA3/SULF1/ROR2/FZD1/ZNF423 10 BP GO:0071773 cellular response to BMP stimulus 10/819 170/18670 0.2139 0.4309 0.3304 MAPK3/SFRP4/GREM1/COMP/BMP4/ITGA3/SULF1/ROR2/FZD1/ZNF423 10 BP GO:1902105 regulation of leukocyte differentiation 15/819 272/18670 0.2162 0.4343 0.3331 PRKCA/BMP4/PIK3R1/IL12A/RASSF2/HAX1/CCR1/GAS6/SOCS5/IL4R/MTOR/IRF7/BAD/ROR2/HLX 15 BP GO:0006801 superoxide metabolic process 5/819 73/18670 0.2162 0.4343 0.3331 SOD3/ITGB2/BST1/FBLN5/SH3PXD2A 5 BP GO:0032945 negative regulation of mononuclear cell proliferation 5/819 73/18670 0.2162 0.4343 0.3331 BMP4/TNFRSF14/PAWR/SDC4/PKN1 5 BP GO:0033555 multicellular organismal response to stress 5/819 73/18670 0.2162 0.4343 0.3331 THBS4/THBS1/GJA1/BCL2/ASIC1 5 BP GO:0050672 negative regulation of lymphocyte proliferation 5/819 73/18670 0.2162 0.4343 0.3331 BMP4/TNFRSF14/PAWR/SDC4/PKN1 5 BP GO:1903524 positive regulation of blood circulation 5/819 73/18670 0.2162 0.4343 0.3331 ATP2A2/GJA1/TPM1/TGFB2/RGS2 5 BP GO:0006672 ceramide metabolic process 6/819 92/18670 0.2166 0.4343 0.3331 PLA2G15/ST3GAL5/CLN3/GM2A/ASAH1/PPP2R1A 6 BP GO:0003215 cardiac right ventricle morphogenesis 2/819 20/18670 0.2181 0.4343 0.3331 TGFB2/SOX4 2 BP GO:0006271 DNA strand elongation involved in DNA replication 2/819 20/18670 0.2181 0.4343 0.3331 RFC3/POLD2 2 BP GO:0006525 arginine metabolic process 2/819 20/18670 0.2181 0.4343 0.3331 DDAH2/FAH 2 BP GO:0008356 asymmetric cell division 2/819 20/18670 0.2181 0.4343 0.3331 SOX5/TEAD3 2 BP GO:0010002 cardioblast differentiation 2/819 20/18670 0.2181 0.4343 0.3331 GREM1/TGFB2 2 BP GO:0032462 regulation of protein homooligomerization 2/819 20/18670 0.2181 0.4343 0.3331 CRYAB/HRK 2 BP GO:0032793 positive regulation of CREB transcription factor activity 2/819 20/18670 0.2181 0.4343 0.3331 ADCY8/PRKD1 2 BP GO:0032816 positive regulation of natural killer cell activation 2/819 20/18670 0.2181 0.4343 0.3331 IL12A/GAS6 2 BP GO:0042276 error-prone translesion synthesis 2/819 20/18670 0.2181 0.4343 0.3331 RFC3/RPA3 2 BP GO:0042535 positive regulation of tumor necrosis factor biosynthetic process 2/819 20/18670 0.2181 0.4343 0.3331 THBS1/JAK2 2 BP GO:0046514 ceramide catabolic process 2/819 20/18670 0.2181 0.4343 0.3331 GM2A/ASAH1 2 BP GO:0051767 nitric-oxide synthase biosynthetic process 2/819 20/18670 0.2181 0.4343 0.3331 JAK2/MAP2K4 2 BP GO:0051769 regulation of nitric-oxide synthase biosynthetic process 2/819 20/18670 0.2181 0.4343 0.3331 JAK2/MAP2K4 2 BP GO:0060602 branch elongation of an epithelium 2/819 20/18670 0.2181 0.4343 0.3331 BMP4/TNC 2 BP GO:0070262 peptidyl-serine dephosphorylation 2/819 20/18670 0.2181 0.4343 0.3331 PPP2R1A/NCK1 2 BP GO:0071636 positive regulation of transforming growth factor beta production 2/819 20/18670 0.2181 0.4343 0.3331 THBS1/WNT11 2 BP GO:0090195 chemokine secretion 2/819 20/18670 0.2181 0.4343 0.3331 POSTN/IL4R 2 BP GO:0097062 dendritic spine maintenance 2/819 20/18670 0.2181 0.4343 0.3331 ITGA3/GRIN2B 2 BP GO:0098698 postsynaptic specialization assembly 2/819 20/18670 0.2181 0.4343 0.3331 IL1RAP/GAP43 2 BP GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2/819 20/18670 0.2181 0.4343 0.3331 TNRC6B/ZFP36 2 BP GO:1900424 regulation of defense response to bacterium 2/819 20/18670 0.2181 0.4343 0.3331 GRN/UNC13B 2 BP GO:1902993 positive regulation of amyloid precursor protein catabolic process 2/819 20/18670 0.2181 0.4343 0.3331 ABCG1/SPON1 2 BP GO:1903204 negative regulation of oxidative stress-induced neuron death 2/819 20/18670 0.2181 0.4343 0.3331 HIF1A/FZD1 2 BP GO:1903978 regulation of microglial cell activation 2/819 20/18670 0.2181 0.4343 0.3331 CTSC/GRN 2 BP GO:0000070 mitotic sister chromatid segregation 9/819 151/18670 0.2188 0.4355 0.334 ESPL1/POGZ/SMC5/RRS1/CHMP2A/PPP2R1A/ANAPC15/KIF2C/IK 9 BP GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 3/819 37/18670 0.2202 0.4355 0.334 SAMD4A/TNRC6B/ZFP36 3 BP GO:0001662 behavioral fear response 3/819 37/18670 0.2202 0.4355 0.334 GJA1/BCL2/ASIC1 3 BP GO:0006270 DNA replication initiation 3/819 37/18670 0.2202 0.4355 0.334 PRIM2/POLE3/PRIM1 3 BP GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 3/819 37/18670 0.2202 0.4355 0.334 RFC3/RPA3/POLD2 3 BP GO:0014037 Schwann cell differentiation 3/819 37/18670 0.2202 0.4355 0.334 MYOC/NTRK2/NAB1 3 BP GO:0031076 embryonic camera-type eye development 3/819 37/18670 0.2202 0.4355 0.334 TFAP2A/ALDH1A3/PHACTR4 3 BP GO:0031111 negative regulation of microtubule polymerization or depolymerization 3/819 37/18670 0.2202 0.4355 0.334 CIB1/FKBP4/CAMSAP2 3 BP GO:0031935 regulation of chromatin silencing 3/819 37/18670 0.2202 0.4355 0.334 PHF2/ASF1A/HMGA1 3 BP GO:0032885 regulation of polysaccharide biosynthetic process 3/819 37/18670 0.2202 0.4355 0.334 ENPP1/HAS2/MTOR 3 BP GO:0038083 peptidyl-tyrosine autophosphorylation 3/819 37/18670 0.2202 0.4355 0.334 MAPK3/GREM1/IQGAP1 3 BP GO:0043114 regulation of vascular permeability 3/819 37/18670 0.2202 0.4355 0.334 RAMP2/ANGPT1/ABR 3 BP GO:0045730 respiratory burst 3/819 37/18670 0.2202 0.4355 0.334 CD55/GRN/CD24 3 BP GO:0045923 positive regulation of fatty acid metabolic process 3/819 37/18670 0.2202 0.4355 0.334 LPGAT1/NR1H2/NR1H3 3 BP GO:0048846 axon extension involved in axon guidance 3/819 37/18670 0.2202 0.4355 0.334 CXCL12/NRP1/NRP2 3 BP GO:1902284 neuron projection extension involved in neuron projection guidance 3/819 37/18670 0.2202 0.4355 0.334 CXCL12/NRP1/NRP2 3 BP GO:1903427 negative regulation of reactive oxygen species biosynthetic process 3/819 37/18670 0.2202 0.4355 0.334 CTNS/TRAP1/STAT3 3 BP GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 3/819 37/18670 0.2202 0.4355 0.334 GSTO1/CLIC2/CACNA1C 3 BP GO:2000273 positive regulation of signaling receptor activity 3/819 37/18670 0.2202 0.4355 0.334 GREM1/EPHB2/ITGB1 3 BP GO:0002011 morphogenesis of an epithelial sheet 4/819 55/18670 0.2209 0.4358 0.3342 CD151/LAMA1/MTOR/PHACTR4 4 BP GO:0016233 telomere capping 4/819 55/18670 0.2209 0.4358 0.3342 MAPK3/MAP3K4/NEK7/TERF2 4 BP GO:0032781 positive regulation of ATPase activity 4/819 55/18670 0.2209 0.4358 0.3342 HSPA2/TPM1/NAPA/ATP1B1 4 BP GO:0045620 negative regulation of lymphocyte differentiation 4/819 55/18670 0.2209 0.4358 0.3342 BMP4/SOCS5/IL4R/HLX 4 BP GO:0098900 regulation of action potential 4/819 55/18670 0.2209 0.4358 0.3342 ATP2A2/CAV3/CACNA1C/BIN1 4 BP GO:0002065 columnar/cuboidal epithelial cell differentiation 7/819 112/18670 0.2212 0.4358 0.3342 ARNTL/RFX3/BMP4/HIF1A/WNT11/BAD/SOX4 7 BP GO:0006354 DNA-templated transcription, elongation 7/819 112/18670 0.2212 0.4358 0.3342 THOC1/POLR2L/POLR2E/ELL2/HMGN1/SUPT4H1/HTATSF1 7 BP GO:0042303 molting cycle 7/819 112/18670 0.2212 0.4358 0.3342 ARNTL/LRIG1/MYO5A/FZD6/PDGFA/TGFB2/BCL2 7 BP GO:0042633 hair cycle 7/819 112/18670 0.2212 0.4358 0.3342 ARNTL/LRIG1/MYO5A/FZD6/PDGFA/TGFB2/BCL2 7 BP GO:0050868 negative regulation of T cell activation 7/819 112/18670 0.2212 0.4358 0.3342 BMP4/TNFRSF14/SOCS5/IL4R/PAWR/SDC4/HLX 7 BP GO:0042177 negative regulation of protein catabolic process 8/819 132/18670 0.2235 0.4396 0.3372 CTSA/PIN1/CLEC16A/UBE2J1/MAP1A/PHB/RYBP/GRIN2A 8 BP GO:0045598 regulation of fat cell differentiation 8/819 132/18670 0.2235 0.4396 0.3372 ENPP1/ADIRF/ARNTL/RARRES2/WWTR1/SNAI2/ZFP36/MTOR 8 BP GO:0034248 regulation of cellular amide metabolic process 25/819 483/18670 0.2235 0.4396 0.3372 MAPK3/THBS1/CTSA/PIN1/ABCG1/HABP4/SAMD4A/ENC1/TNRC6B/NOLC1/TRAP1/STAT3/PDK1/RGS2/ZFP36/MTOR/SPON1/RPS6KB2/ITGA2/BIN1/PDK2/PER2/FOXO3/SOX4/NCK1 25 BP GO:0003073 regulation of systemic arterial blood pressure 6/819 93/18670 0.2237 0.4396 0.3372 PCSK5/PRCP/POSTN/GJA1/TPM1/GAS6 6 BP GO:0046634 regulation of alpha-beta T cell activation 6/819 93/18670 0.2237 0.4396 0.3372 CD55/IL12A/TNFRSF14/SOCS5/IL4R/HLX 6 BP GO:0048704 embryonic skeletal system morphogenesis 6/819 93/18670 0.2237 0.4396 0.3372 SATB2/COL11A1/BMP4/TGFBR1/TFAP2A/MTHFD1 6 BP GO:1901655 cellular response to ketone 6/819 93/18670 0.2237 0.4396 0.3372 ADCY8/ADAM15/KLF4/TNC/CASP9/FOXO3 6 BP GO:0051262 protein tetramerization 10/819 172/18670 0.2241 0.4399 0.3374 ACOT13/PCBD1/HMGCL/FBP1/XRCC6/GPX3/GRIN2B/RRM2/ALDH1A3/CAT 10 BP GO:0005977 glycogen metabolic process 5/819 74/18670 0.2243 0.4399 0.3374 ENPP1/IL6ST/MTOR/PGM1/PER2 5 BP GO:0009064 glutamine family amino acid metabolic process 5/819 74/18670 0.2243 0.4399 0.3374 PYCR1/DDAH2/FAH/GCLM/CTPS1 5 BP GO:0030104 water homeostasis 5/819 74/18670 0.2243 0.4399 0.3374 ADCY8/CLDN4/ADCY7/MET/HAS2 5 BP GO:1900006 positive regulation of dendrite development 5/819 74/18670 0.2243 0.4399 0.3374 IQGAP1/LPAR1/MTOR/VLDLR/CAMK1 5 BP GO:0016358 dendrite development 13/819 233/18670 0.2247 0.4407 0.3379 TRAK2/EPHB2/ARF4/IQGAP1/NRP1/LPAR1/MTOR/CAMSAP2/MAP1A/TRPC6/VLDLR/ITGB1/CAMK1 13 BP GO:0050768 negative regulation of neurogenesis 16/819 295/18670 0.2256 0.4422 0.3392 COL3A1/IDH2/TRAK2/EPHB2/CIB1/DPYSL3/NRP1/FKBP4/THY1/STAT3/NOTCH3/PMP22/LPAR1/RAB29/TRPC6/FOXO3 16 BP GO:1902749 regulation of cell cycle G2/M phase transition 12/819 213/18670 0.2266 0.4441 0.3406 PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/PSMB6/SYF2/PPP2R1A/PSMD3/CKAP5/PSMD2/PSMB8 12 BP GO:0032609 interferon-gamma production 7/819 113/18670 0.2276 0.4459 0.342 IL18R1/ISG15/IL12A/PDE4B/GAS6/TCIRG1/HLA-DPB1 7 BP GO:0043270 positive regulation of ion transport 15/819 275/18670 0.2284 0.4472 0.343 GSTO1/ATP8A1/CEMIP/CXCL12/EPHB2/HSPA2/MYLK/CCR1/THY1/ATP1B1/ARRB2/STAC/GPD1L/KCNMB1/TRPC6 15 BP GO:0051249 regulation of lymphocyte activation 25/819 485/18670 0.2296 0.4495 0.3447 CD55/THOC1/BMP4/PIK3R1/CD70/IL12A/TNFRSF14/GSN/CD24/THY1/BST1/GAS6/SOCS5/IL6ST/IL4R/IGLL1/BAD/BCL2/PTPN11/PAWR/SDC4/PKN1/NCK1/HLX/HLA-DPB1 25 BP GO:0006261 DNA-dependent DNA replication 9/819 153/18670 0.2298 0.4496 0.3448 THOC1/PRIM2/RFC3/POLE3/RPA3/TERF2/PRIM1/POLD2/HMGA1 9 BP GO:0062013 positive regulation of small molecule metabolic process 9/819 153/18670 0.2298 0.4496 0.3448 LPGAT1/ABCG1/NUPR1/KAT2B/NR1H2/NR1H3/HIF1A/HAS2/STAT3 9 BP GO:0022029 telencephalon cell migration 4/819 56/18670 0.2303 0.4498 0.3449 CXCL12/LAMB1/NRP1/NRP2 4 BP GO:0031295 T cell costimulation 4/819 56/18670 0.2303 0.4498 0.3449 PIK3R1/TNFRSF14/CD24/PTPN11 4 BP GO:0032615 interleukin-12 production 4/819 56/18670 0.2303 0.4498 0.3449 THBS1/MAST2/ARRB2/PLCB1 4 BP GO:0060113 inner ear receptor cell differentiation 4/819 56/18670 0.2303 0.4498 0.3449 NAGLU/BMP4/FZD2/SDC4 4 BP GO:0086065 cell communication involved in cardiac conduction 4/819 56/18670 0.2303 0.4498 0.3449 GJA1/GJC1/ATP1B1/CACNA1C 4 BP GO:0045621 positive regulation of lymphocyte differentiation 6/819 94/18670 0.2309 0.4504 0.3455 IL12A/GAS6/SOCS5/IL4R/BAD/HLX 6 BP GO:0051289 protein homotetramerization 6/819 94/18670 0.2309 0.4504 0.3455 ACOT13/PCBD1/FBP1/GPX3/ALDH1A3/CAT 6 BP GO:0007254 JNK cascade 12/819 214/18670 0.2313 0.4505 0.3455 MAP3K4/FZD7/SASH1/MDFIC/RASSF2/MAP3K5/MAP4K2/RAPGEF1/ROR2/MAP2K4/PLCB1/PKN1 12 BP GO:0045732 positive regulation of protein catabolic process 12/819 214/18670 0.2313 0.4505 0.3455 CTSC/USP5/RAD23A/GJA1/NUPR1/RNF144A/VPS11/CAV3/PTTG1IP/SOCS5/RCHY1/EZR 12 BP GO:0002209 behavioral defense response 3/819 38/18670 0.2319 0.4505 0.3455 GJA1/BCL2/ASIC1 3 BP GO:0006298 mismatch repair 3/819 38/18670 0.2319 0.4505 0.3455 RPA3/POLD2/XPC 3 BP GO:0007190 activation of adenylate cyclase activity 3/819 38/18670 0.2319 0.4505 0.3455 ADCY8/ADCY7/EDNRA 3 BP GO:0007340 acrosome reaction 3/819 38/18670 0.2319 0.4505 0.3455 GLRB/UNC13B/PLCB1 3 BP GO:0009225 nucleotide-sugar metabolic process 3/819 38/18670 0.2319 0.4505 0.3455 RENBP/GUK1/GNPDA1 3 BP GO:0035329 hippo signaling 3/819 38/18670 0.2319 0.4505 0.3455 WWTR1/TEAD3/TEAD4 3 BP GO:0046676 negative regulation of insulin secretion 3/819 38/18670 0.2319 0.4505 0.3455 INHBB/HADH/PTPN11 3 BP GO:0048246 macrophage chemotaxis 3/819 38/18670 0.2319 0.4505 0.3455 MAPK3/RARRES2/THBS1 3 BP GO:0086091 regulation of heart rate by cardiac conduction 3/819 38/18670 0.2319 0.4505 0.3455 KCND3/CACNA1C/BIN1 3 BP GO:1903523 negative regulation of blood circulation 3/819 38/18670 0.2319 0.4505 0.3455 ATP2A2/JAK2/BIN1 3 BP GO:2000279 negative regulation of DNA biosynthetic process 3/819 38/18670 0.2319 0.4505 0.3455 GJA1/DNAJC2/TERF2 3 BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 5/819 75/18670 0.2324 0.4505 0.3455 PXDN/ADAR/NR1H2/NR1H3/GAS6 5 BP GO:0006073 cellular glucan metabolic process 5/819 75/18670 0.2324 0.4505 0.3455 ENPP1/IL6ST/MTOR/PGM1/PER2 5 BP GO:0006695 cholesterol biosynthetic process 5/819 75/18670 0.2324 0.4505 0.3455 TM7SF2/ABCG1/LBR/MBTPS1/NFYB 5 BP GO:0015914 phospholipid transport 5/819 75/18670 0.2324 0.4505 0.3455 ATP8A1/ABCG1/ATP11B/PLTP/KCNN4 5 BP GO:0044042 glucan metabolic process 5/819 75/18670 0.2324 0.4505 0.3455 ENPP1/IL6ST/MTOR/PGM1/PER2 5 BP GO:0009755 hormone-mediated signaling pathway 13/819 235/18670 0.2336 0.4505 0.3455 VDR/ARNTL/PRCP/BMP4/NR1H2/NR1H3/FKBP4/WBP2/ARRB2/JAK2/STRN3/PTPN11/PHB 13 BP GO:0008543 fibroblast growth factor receptor signaling pathway 7/819 114/18670 0.2341 0.4505 0.3455 MAPK3/POLR2L/THBS1/POLR2E/IQGAP1/SULF1/PTPN11 7 BP GO:0002029 desensitization of G protein-coupled receptor signaling pathway 2/819 21/18670 0.2345 0.4505 0.3455 ARRB2/HTR2B 2 BP GO:0003177 pulmonary valve development 2/819 21/18670 0.2345 0.4505 0.3455 BMP4/TGFB2 2 BP GO:0003283 atrial septum development 2/819 21/18670 0.2345 0.4505 0.3455 TGFB2/SOX4 2 BP GO:0010310 regulation of hydrogen peroxide metabolic process 2/819 21/18670 0.2345 0.4505 0.3455 CTNS/STAT3 2 BP GO:0017000 antibiotic biosynthetic process 2/819 21/18670 0.2345 0.4505 0.3455 CTNS/STAT3 2 BP GO:0022401 negative adaptation of signaling pathway 2/819 21/18670 0.2345 0.4505 0.3455 ARRB2/HTR2B 2 BP GO:0031290 retinal ganglion cell axon guidance 2/819 21/18670 0.2345 0.4505 0.3455 EPHB2/NRP1 2 BP GO:0031498 chromatin disassembly 2/819 21/18670 0.2345 0.4505 0.3455 SMARCE1/HMGA1 2 BP GO:0032332 positive regulation of chondrocyte differentiation 2/819 21/18670 0.2345 0.4505 0.3455 SOX5/LOXL2 2 BP GO:0032682 negative regulation of chemokine production 2/819 21/18670 0.2345 0.4505 0.3455 KLF4/SOCS5 2 BP GO:0032891 negative regulation of organic acid transport 2/819 21/18670 0.2345 0.4505 0.3455 THBS1/RGS2 2 BP GO:0032986 protein-DNA complex disassembly 2/819 21/18670 0.2345 0.4505 0.3455 SMARCE1/HMGA1 2 BP GO:0036120 cellular response to platelet-derived growth factor stimulus 2/819 21/18670 0.2345 0.4505 0.3455 IQGAP1/HAS2 2 BP GO:0039702 viral budding via host ESCRT complex 2/819 21/18670 0.2345 0.4505 0.3455 CHMP2A/TSG101 2 BP GO:0045026 plasma membrane fusion 2/819 21/18670 0.2345 0.4505 0.3455 FOLR3/FOLR2 2 BP GO:0046132 pyrimidine ribonucleoside biosynthetic process 2/819 21/18670 0.2345 0.4505 0.3455 NME3/CTPS1 2 BP GO:0050951 sensory perception of temperature stimulus 2/819 21/18670 0.2345 0.4505 0.3455 CXCL12/ARRB2 2 BP GO:0055093 response to hyperoxia 2/819 21/18670 0.2345 0.4505 0.3455 COL1A1/CAT 2 BP GO:0070584 mitochondrion morphogenesis 2/819 21/18670 0.2345 0.4505 0.3455 BCL2L1/NDUFS6 2 BP GO:1900273 positive regulation of long-term synaptic potentiation 2/819 21/18670 0.2345 0.4505 0.3455 ADCY8/EPHB2 2 BP GO:1902884 positive regulation of response to oxidative stress 2/819 21/18670 0.2345 0.4505 0.3455 PAWR/FOXO3 2 BP GO:1903392 negative regulation of adherens junction organization 2/819 21/18670 0.2345 0.4505 0.3455 THBS1/ITGB1BP1 2 BP GO:1904886 beta-catenin destruction complex disassembly 2/819 21/18670 0.2345 0.4505 0.3455 FZD2/FZD1 2 BP GO:2000810 regulation of bicellular tight junction assembly 2/819 21/18670 0.2345 0.4505 0.3455 GJA1/SNAI2 2 BP GO:0006839 mitochondrial transport 14/819 256/18670 0.2353 0.4517 0.3464 HIP1R/TOMM34/BCL2L1/VPS11/SLC25A16/HAX1/NMT1/COX5B/STAT3/UCP2/BAD/BCL2/HEBP2/LMAN1 14 BP GO:0007006 mitochondrial membrane organization 8/819 134/18670 0.2354 0.4517 0.3464 HIP1R/BCL2L1/DNAJC11/NMT1/STAT3/BAD/BCL2/HEBP2 8 BP GO:0010770 positive regulation of cell morphogenesis involved in differentiation 9/819 154/18670 0.2354 0.4517 0.3464 MYOC/CXCL12/NTRK2/PLXND1/CIB1/NRP1/HAS2/TWF2/PLXNC1 9 BP GO:0002218 activation of innate immune response 17/819 319/18670 0.238 0.4564 0.35 MAPKAPK3/PSMD8/PSMB7/PSMD1/ITGB2/NR1H3/PIK3C3/XRCC6/PSMB6/ARRB2/RSAD2/HEXIM1/IRF7/PSMD3/PSMD2/PSMB8/CREBBP 17 BP GO:0042100 B cell proliferation 6/819 95/18670 0.2381 0.4564 0.35 CD70/BST1/BCL2/PAWR/PKN1/CTPS1 6 BP GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 6/819 95/18670 0.2381 0.4564 0.35 USP5/RAD23A/RNF144A/CAV3/SOCS5/RCHY1 6 BP GO:0014888 striated muscle adaptation 4/819 57/18670 0.2399 0.4588 0.3519 MYOC/ATP2A2/GSN/MTOR 4 BP GO:0018208 peptidyl-proline modification 4/819 57/18670 0.2399 0.4588 0.3519 PIN1/P4HA1/FKBP4/PPIB 4 BP GO:0031294 lymphocyte costimulation 4/819 57/18670 0.2399 0.4588 0.3519 PIK3R1/TNFRSF14/CD24/PTPN11 4 BP GO:0033344 cholesterol efflux 4/819 57/18670 0.2399 0.4588 0.3519 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0060760 positive regulation of response to cytokine stimulus 4/819 57/18670 0.2399 0.4588 0.3519 HIF1A/GAS6/IRF7/AGPAT1 4 BP GO:1901799 negative regulation of proteasomal protein catabolic process 4/819 57/18670 0.2399 0.4588 0.3519 CLEC16A/UBE2J1/MAP1A/RYBP 4 BP GO:0000422 autophagy of mitochondrion 5/819 76/18670 0.2405 0.4596 0.3525 ATG2A/HAX1/HIF1A/CLEC16A/MAP1LC3B 5 BP GO:0061726 mitochondrion disassembly 5/819 76/18670 0.2405 0.4596 0.3525 ATG2A/HAX1/HIF1A/CLEC16A/MAP1LC3B 5 BP GO:1902653 secondary alcohol biosynthetic process 5/819 76/18670 0.2405 0.4596 0.3525 TM7SF2/ABCG1/LBR/MBTPS1/NFYB 5 BP GO:0030010 establishment of cell polarity 8/819 135/18670 0.2415 0.4612 0.3537 PTK7/NSFL1C/MYH9/GSN/FSCN1/SNX27/LAMA1/CYTH1 8 BP GO:0019048 modulation by virus of host morphology or physiology 3/819 39/18670 0.2438 0.4641 0.3559 BCL2L1/BAD/KPNA3 3 BP GO:0030049 muscle filament sliding 3/819 39/18670 0.2438 0.4641 0.3559 TPM2/TPM1/TMOD1 3 BP GO:0033275 actin-myosin filament sliding 3/819 39/18670 0.2438 0.4641 0.3559 TPM2/TPM1/TMOD1 3 BP GO:0033683 nucleotide-excision repair, DNA incision 3/819 39/18670 0.2438 0.4641 0.3559 RFC3/RPA3/POLD2 3 BP GO:0038179 neurotrophin signaling pathway 3/819 39/18670 0.2438 0.4641 0.3559 NTRK2/RAPGEF1/PTPN11 3 BP GO:0042417 dopamine metabolic process 3/819 39/18670 0.2438 0.4641 0.3559 ITGB2/TGFB2/GRIN2A 3 BP GO:0043001 Golgi to plasma membrane protein transport 3/819 39/18670 0.2438 0.4641 0.3559 KRT18/SPTBN1/VAMP3 3 BP GO:0060306 regulation of membrane repolarization 3/819 39/18670 0.2438 0.4641 0.3559 GJA1/SNTA1/CAV3 3 BP GO:0072529 pyrimidine-containing compound catabolic process 3/819 39/18670 0.2438 0.4641 0.3559 APOBEC3B/MBD4/APOBEC3C 3 BP GO:0000082 G1/S transition of mitotic cell cycle 15/819 279/18670 0.245 0.4662 0.3576 NACC2/PRIM2/CCND2/POLE3/RPA3/PRMT1/KLF4/PRIM1/RRM2/BCL2/PLCB1/SOX4/CTDSP2/CDKN2A/ITGB1 15 BP GO:0006835 dicarboxylic acid transport 6/819 96/18670 0.2454 0.4664 0.3577 FOLR3/PPFIA4/FOLR2/NTRK2/UNC13B/PER2 6 BP GO:0019217 regulation of fatty acid metabolic process 6/819 96/18670 0.2454 0.4664 0.3577 LPGAT1/NR1H2/NR1H3/PDK1/MTOR/PDK2 6 BP GO:0042632 cholesterol homeostasis 6/819 96/18670 0.2454 0.4664 0.3577 GRAMD1B/ABCG1/NR1H2/NR1H3/CD24/CAV3 6 BP GO:0098876 vesicle-mediated transport to the plasma membrane 6/819 96/18670 0.2454 0.4664 0.3577 ARF4/SNX27/RAB8A/KRT18/SPTBN1/VAMP3 6 BP GO:0045861 negative regulation of proteolysis 19/819 363/18670 0.2457 0.4669 0.3581 RENBP/CD55/CRYAB/SIAH2/THBS1/CLN3/SERPINH1/LAMTOR5/COL6A3/CLEC16A/COL7A1/UBE2J1/SERPINB6/ARRB2/KLF4/GAS6/BIN1/MAP1A/RYBP 19 BP GO:0034767 positive regulation of ion transmembrane transport 9/819 156/18670 0.2467 0.4686 0.3594 GSTO1/CEMIP/EPHB2/HSPA2/THY1/ATP1B1/STAC/KCNMB1/TRPC6 9 BP GO:0051048 negative regulation of secretion 13/819 238/18670 0.2472 0.4694 0.36 IDH2/ANGPT1/NR1H3/ABR/INHBB/HADH/IL13RA2/GAS6/RSAD2/PTPN11/ASIC1/EZR/VAMP3 13 BP GO:0007292 female gamete generation 8/819 136/18670 0.2476 0.4694 0.36 INHBB/ETV6/RGS2/IL4R/BCL2/PPP2R1A/PTX3/FOXO3 8 BP GO:0010952 positive regulation of peptidase activity 11/819 197/18670 0.2481 0.4694 0.36 MAPK3/HIP1R/GRN/MAP3K5/GSN/STAT3/JAK2/GRIN2B/BAD/CASP9/GRIN2A 11 BP GO:0031397 negative regulation of protein ubiquitination 5/819 77/18670 0.2488 0.4694 0.36 ISG15/ARRB2/MTOR/PER2/SOX4 5 BP GO:0035050 embryonic heart tube development 5/819 77/18670 0.2488 0.4694 0.36 MICAL2/GJA1/FOXC1/HIF1A/TMED2 5 BP GO:0051851 modification by host of symbiont morphology or physiology 5/819 77/18670 0.2488 0.4694 0.36 PPIB/CHD1/IFI27/FBXL2/PTX3 5 BP GO:0031663 lipopolysaccharide-mediated signaling pathway 4/819 58/18670 0.2495 0.4694 0.36 MAPK3/CD55/PRKCA/SASH1 4 BP GO:0055081 anion homeostasis 4/819 58/18670 0.2495 0.4694 0.36 ENPP1/SFRP4/ABCG1/CKB 4 BP GO:0061900 glial cell activation 4/819 58/18670 0.2495 0.4694 0.36 CTSC/GRN/ITGB2/JAK2 4 BP GO:0061951 establishment of protein localization to plasma membrane 4/819 58/18670 0.2495 0.4694 0.36 RAB8A/KRT18/SPTBN1/VAMP3 4 BP GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/819 58/18670 0.2495 0.4694 0.36 VPS11/NMT1/BAD/BCL2 4 BP GO:0010769 regulation of cell morphogenesis involved in differentiation 16/819 301/18670 0.2496 0.4694 0.36 MYOC/TRAK2/CXCL12/POSTN/EPHB2/NTRK2/PLXND1/CIB1/NRP1/HAS2/CHN1/TWF2/THY1/ITGB1BP1/PLXNC1/TRPC6 16 BP GO:0019083 viral transcription 10/819 177/18670 0.2505 0.4694 0.36 POLR2L/POLR2E/MDFIC/NUP205/NUP93/NUP153/SUPT4H1/ZFP36/SEC13/CHD1 10 BP GO:0048469 cell maturation 10/819 177/18670 0.2505 0.4694 0.36 MYOC/RFX3/GJA1/DEFB1/HIF1A/EPAS1/MTOR/BCL2/PPP2R1A/FOXO3 10 BP GO:0002052 positive regulation of neuroblast proliferation 2/819 22/18670 0.251 0.4694 0.36 VEGFC/HIF1A 2 BP GO:0002089 lens morphogenesis in camera-type eye 2/819 22/18670 0.251 0.4694 0.36 BMP4/TDRD7 2 BP GO:0006085 acetyl-CoA biosynthetic process 2/819 22/18670 0.251 0.4694 0.36 PDK1/PDK2 2 BP GO:0006312 mitotic recombination 2/819 22/18670 0.251 0.4694 0.36 SMC5/TERF2 2 BP GO:0007063 regulation of sister chromatid cohesion 2/819 22/18670 0.251 0.4694 0.36 ESPL1/SMC5 2 BP GO:0007289 spermatid nucleus differentiation 2/819 22/18670 0.251 0.4694 0.36 AGFG1/TMF1 2 BP GO:0007398 ectoderm development 2/819 22/18670 0.251 0.4694 0.36 FZD7/ITGA6 2 BP GO:0009190 cyclic nucleotide biosynthetic process 2/819 22/18670 0.251 0.4694 0.36 ADCY8/ADCY7 2 BP GO:0009220 pyrimidine ribonucleotide biosynthetic process 2/819 22/18670 0.251 0.4694 0.36 NME3/CTPS1 2 BP GO:0010866 regulation of triglyceride biosynthetic process 2/819 22/18670 0.251 0.4694 0.36 NR1H2/NR1H3 2 BP GO:0016226 iron-sulfur cluster assembly 2/819 22/18670 0.251 0.4694 0.36 ISCA1/CIAO1 2 BP GO:0023058 adaptation of signaling pathway 2/819 22/18670 0.251 0.4694 0.36 ARRB2/HTR2B 2 BP GO:0031163 metallo-sulfur cluster assembly 2/819 22/18670 0.251 0.4694 0.36 ISCA1/CIAO1 2 BP GO:0031281 positive regulation of cyclase activity 2/819 22/18670 0.251 0.4694 0.36 MAPK3/CACNA1C 2 BP GO:0032402 melanosome transport 2/819 22/18670 0.251 0.4694 0.36 RAB27B/MYO5A 2 BP GO:0034643 establishment of mitochondrion localization, microtubule-mediated 2/819 22/18670 0.251 0.4694 0.36 TRAK2/HIF1A 2 BP GO:0036119 response to platelet-derived growth factor 2/819 22/18670 0.251 0.4694 0.36 IQGAP1/HAS2 2 BP GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 2/819 22/18670 0.251 0.4694 0.36 THBS1/SULF1 2 BP GO:0044321 response to leptin 2/819 22/18670 0.251 0.4694 0.36 INHBB/STAT3 2 BP GO:0044342 type B pancreatic cell proliferation 2/819 22/18670 0.251 0.4694 0.36 NUPR1/BAD 2 BP GO:0045649 regulation of macrophage differentiation 2/819 22/18670 0.251 0.4694 0.36 PRKCA/ROR2 2 BP GO:0045663 positive regulation of myoblast differentiation 2/819 22/18670 0.251 0.4694 0.36 MAP3K5/PLCB1 2 BP GO:0045943 positive regulation of transcription by RNA polymerase I 2/819 22/18670 0.251 0.4694 0.36 WDR43/MTOR 2 BP GO:0046599 regulation of centriole replication 2/819 22/18670 0.251 0.4694 0.36 KAT2B/CHMP2A 2 BP GO:0047497 mitochondrion transport along microtubule 2/819 22/18670 0.251 0.4694 0.36 TRAK2/HIF1A 2 BP GO:0052652 cyclic purine nucleotide metabolic process 2/819 22/18670 0.251 0.4694 0.36 ADCY8/ADCY7 2 BP GO:0060065 uterus development 2/819 22/18670 0.251 0.4694 0.36 KDM5B/TGFB2 2 BP GO:0070935 3'-UTR-mediated mRNA stabilization 2/819 22/18670 0.251 0.4694 0.36 HNRNPA0/ZFP36 2 BP GO:0072643 interferon-gamma secretion 2/819 22/18670 0.251 0.4694 0.36 ISG15/TCIRG1 2 BP GO:0090189 regulation of branching involved in ureteric bud morphogenesis 2/819 22/18670 0.251 0.4694 0.36 MAGED1/BMP4 2 BP GO:0097320 plasma membrane tubulation 2/819 22/18670 0.251 0.4694 0.36 SH3GL2/PLEKHM2 2 BP GO:0030316 osteoclast differentiation 6/819 97/18670 0.2527 0.4718 0.3618 PIK3R1/RASSF2/CCR1/MTOR/TCIRG1/SH3PXD2A 6 BP GO:0043255 regulation of carbohydrate biosynthetic process 6/819 97/18670 0.2527 0.4718 0.3618 ENPP1/KAT2B/FBP1/HAS2/MTOR/PDK2 6 BP GO:0048709 oligodendrocyte differentiation 6/819 97/18670 0.2527 0.4718 0.3618 NTRK2/PLP1/GSN/TSPAN2/LPAR1/MTOR 6 BP GO:0055092 sterol homeostasis 6/819 97/18670 0.2527 0.4718 0.3618 GRAMD1B/ABCG1/NR1H2/NR1H3/CD24/CAV3 6 BP GO:0090630 activation of GTPase activity 6/819 97/18670 0.2527 0.4718 0.3618 RANGAP1/TBC1D4/ABR/RAPGEF1/RABGAP1L/PIP5K1A 6 BP GO:0010508 positive regulation of autophagy 7/819 117/18670 0.254 0.4737 0.3633 MAPK3/PRKD1/HIF1A/CLEC16A/PIK3CB/BAD/FOXO3 7 BP GO:0010822 positive regulation of mitochondrion organization 7/819 117/18670 0.254 0.4737 0.3633 HIP1R/HRK/VPS11/HIF1A/NMT1/BAD/BCL2 7 BP GO:0010906 regulation of glucose metabolic process 7/819 117/18670 0.254 0.4737 0.3633 ENPP1/KAT2B/FBP1/PDK1/MTOR/BAD/PDK2 7 BP GO:0009187 cyclic nucleotide metabolic process 3/819 40/18670 0.2557 0.4756 0.3648 ADCY8/ADCY7/PDE4B 3 BP GO:0009268 response to pH 3/819 40/18670 0.2557 0.4756 0.3648 GJA1/CLCN7/ASIC1 3 BP GO:0009395 phospholipid catabolic process 3/819 40/18670 0.2557 0.4756 0.3648 PLA2G15/PLA2G4C/ENPP2 3 BP GO:0042026 protein refolding 3/819 40/18670 0.2557 0.4756 0.3648 HSPA5/HSPA2/PPIB 3 BP GO:0042596 fear response 3/819 40/18670 0.2557 0.4756 0.3648 GJA1/BCL2/ASIC1 3 BP GO:0046621 negative regulation of organ growth 3/819 40/18670 0.2557 0.4756 0.3648 GJA1/CAV3/RGS2 3 BP GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 3/819 40/18670 0.2557 0.4756 0.3648 GSTO1/CEMIP/THY1 3 BP GO:0022406 membrane docking 10/819 178/18670 0.2559 0.4757 0.3648 HAUS7/ESYT1/VPS11/RAB8A/UNC13B/PPP2R1A/VPS45/CKAP5/EZR/VAMP3 10 BP GO:2001257 regulation of cation channel activity 10/819 178/18670 0.2559 0.4757 0.3648 GSTO1/CLIC2/EPHB2/MYO5A/PDE4B/GNB5/ANXA3/STAC/GRIN2B/GRIN2A 10 BP GO:0006487 protein N-linked glycosylation 5/819 78/18670 0.2571 0.4774 0.3661 ST6GAL1/UBE2J1/DPM2/LMAN1/STT3A 5 BP GO:0032413 negative regulation of ion transmembrane transporter activity 5/819 78/18670 0.2571 0.4774 0.3661 GSTO1/CLIC2/EPHB2/GNB5/CAV3 5 BP GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 5/819 78/18670 0.2571 0.4774 0.3661 ARNTL/WBP2/ARRB2/STRN3/PHB 5 BP GO:0043407 negative regulation of MAP kinase activity 5/819 78/18670 0.2571 0.4774 0.3661 BMP4/CAV3/RGS2/DUSP7/PPP2R1A 5 BP GO:1903311 regulation of mRNA metabolic process 17/819 324/18670 0.2577 0.4783 0.3668 PSMD8/PSMB7/PRKCA/EXOSC7/PSMD1/HNRNPA0/SAMD4A/TNRC6B/PSMB6/ZFP36/EXOSC2/MTOR/SAP18/PSMD3/SRSF7/PSMD2/PSMB8 17 BP GO:0021885 forebrain cell migration 4/819 59/18670 0.2592 0.4802 0.3683 CXCL12/LAMB1/NRP1/NRP2 4 BP GO:0032890 regulation of organic acid transport 4/819 59/18670 0.2592 0.4802 0.3683 THBS1/SV2A/RGS2/PER2 4 BP GO:0042130 negative regulation of T cell proliferation 4/819 59/18670 0.2592 0.4802 0.3683 BMP4/TNFRSF14/PAWR/SDC4 4 BP GO:0097755 positive regulation of blood vessel diameter 4/819 59/18670 0.2592 0.4802 0.3683 ITGA1/GJA1/RGS2/KCNMB1 4 BP GO:2000756 regulation of peptidyl-lysine acetylation 4/819 59/18670 0.2592 0.4802 0.3683 MAPK3/SNAI2/WBP2/SOX4 4 BP GO:0031341 regulation of cell killing 6/819 98/18670 0.2602 0.4819 0.3696 CD55/MICB/IL12A/ARRB2/DNASE1L3/BAD 6 BP GO:1903034 regulation of response to wounding 10/819 179/18670 0.2613 0.4838 0.3711 THBS1/PRKCA/GRN/GJA1/MYH9/MYLK/FAP/PDGFA/KLF4/MTOR 10 BP GO:0007281 germ cell development 14/819 262/18670 0.2617 0.4844 0.3715 BMP4/BCL2L1/CIB1/HSPA2/INHBB/DEFB1/UBE2J1/MTOR/BCL2/PPP2R1A/PTX3/FOXO3/AGFG1/TMF1 14 BP GO:0016569 covalent chromatin modification 24/819 474/18670 0.2626 0.4859 0.3726 MAPK3/NACC2/KDM5B/PRKCA/PHF2/PRKD1/KAT2B/POLE3/SETD1B/SNAI2/WBP2/PRMT1/JAK2/PRKCB/JADE2/CHD1/UBE2E1/KDM6A/PHB/PER2/HSF4/RYBP/PKN1/CREBBP 24 BP GO:0001570 vasculogenesis 5/819 79/18670 0.2655 0.4884 0.3746 RAMP2/NTRK2/GJC1/HAS2/RASA1 5 BP GO:1903312 negative regulation of mRNA metabolic process 5/819 79/18670 0.2655 0.4884 0.3746 HNRNPA0/ZFP36/MTOR/SAP18/SRSF7 5 BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 8/819 139/18670 0.2662 0.4884 0.3746 MAPK3/PIK3R1/MYO10/ARPC1B/PIK3R2/PIK3CB/RAPGEF1/NCK1 8 BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 8/819 139/18670 0.2662 0.4884 0.3746 MAPK3/PIK3R1/MYO10/ARPC1B/PIK3R2/PIK3CB/RAPGEF1/NCK1 8 BP GO:0030705 cytoskeleton-dependent intracellular transport 10/819 180/18670 0.2668 0.4884 0.3746 TRAK2/CLN3/RAB27B/MYO10/MYO5A/HIF1A/SPG11/DYNC1I1/TERF2/MAP1A 10 BP GO:0016570 histone modification 23/819 454/18670 0.2673 0.4884 0.3746 MAPK3/NACC2/KDM5B/PRKCA/PHF2/PRKD1/KAT2B/POLE3/SETD1B/SNAI2/WBP2/PRMT1/JAK2/PRKCB/JADE2/UBE2E1/KDM6A/PHB/PER2/HSF4/RYBP/PKN1/CREBBP 23 BP GO:0000715 nucleotide-excision repair, DNA damage recognition 2/819 23/18670 0.2675 0.4884 0.3746 COPS8/XPC 2 BP GO:0002347 response to tumor cell 2/819 23/18670 0.2675 0.4884 0.3746 IL12A/ADAM15 2 BP GO:0006359 regulation of transcription by RNA polymerase III 2/819 23/18670 0.2675 0.4884 0.3746 POLR3G/MTOR 2 BP GO:0007064 mitotic sister chromatid cohesion 2/819 23/18670 0.2675 0.4884 0.3746 POGZ/SMC5 2 BP GO:0007413 axonal fasciculation 2/819 23/18670 0.2675 0.4884 0.3746 EPHB2/NRP1 2 BP GO:0009147 pyrimidine nucleoside triphosphate metabolic process 2/819 23/18670 0.2675 0.4884 0.3746 NME3/CTPS1 2 BP GO:0009226 nucleotide-sugar biosynthetic process 2/819 23/18670 0.2675 0.4884 0.3746 RENBP/GNPDA1 2 BP GO:0010528 regulation of transposition 2/819 23/18670 0.2675 0.4884 0.3746 APOBEC3B/APOBEC3C 2 BP GO:0010529 negative regulation of transposition 2/819 23/18670 0.2675 0.4884 0.3746 APOBEC3B/APOBEC3C 2 BP GO:0019400 alditol metabolic process 2/819 23/18670 0.2675 0.4884 0.3746 SORD/TPI1 2 BP GO:0030539 male genitalia development 2/819 23/18670 0.2675 0.4884 0.3746 ASB1/ROR2 2 BP GO:0032401 establishment of melanosome localization 2/819 23/18670 0.2675 0.4884 0.3746 RAB27B/MYO5A 2 BP GO:0032703 negative regulation of interleukin-2 production 2/819 23/18670 0.2675 0.4884 0.3746 ZFP36/EZR 2 BP GO:0034123 positive regulation of toll-like receptor signaling pathway 2/819 23/18670 0.2675 0.4884 0.3746 NR1H3/RSAD2 2 BP GO:0042451 purine nucleoside biosynthetic process 2/819 23/18670 0.2675 0.4884 0.3746 NME3/GUK1 2 BP GO:0042454 ribonucleoside catabolic process 2/819 23/18670 0.2675 0.4884 0.3746 APOBEC3B/APOBEC3C 2 BP GO:0046129 purine ribonucleoside biosynthetic process 2/819 23/18670 0.2675 0.4884 0.3746 NME3/GUK1 2 BP GO:0046337 phosphatidylethanolamine metabolic process 2/819 23/18670 0.2675 0.4884 0.3746 PLA2G15/PCYT2 2 BP GO:0051904 pigment granule transport 2/819 23/18670 0.2675 0.4884 0.3746 RAB27B/MYO5A 2 BP GO:0061436 establishment of skin barrier 2/819 23/18670 0.2675 0.4884 0.3746 CLDN4/MET 2 BP GO:0071467 cellular response to pH 2/819 23/18670 0.2675 0.4884 0.3746 GJA1/ASIC1 2 BP GO:0086012 membrane depolarization during cardiac muscle cell action potential 2/819 23/18670 0.2675 0.4884 0.3746 CAV3/CACNA1C 2 BP GO:0106030 neuron projection fasciculation 2/819 23/18670 0.2675 0.4884 0.3746 EPHB2/NRP1 2 BP GO:1901889 negative regulation of cell junction assembly 2/819 23/18670 0.2675 0.4884 0.3746 THBS1/ITGB1BP1 2 BP GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/819 23/18670 0.2675 0.4884 0.3746 PTTG1IP/BCL2 2 BP GO:0007368 determination of left/right symmetry 7/819 119/18670 0.2675 0.4884 0.3746 PCSK5/MICAL2/RFX3/GJA1/BICC1/HIF1A/TMED2 7 BP GO:0032392 DNA geometric change 7/819 119/18670 0.2675 0.4884 0.3746 SMARCA1/RFC3/XRCC6/CHD1/MTERF1/HMGA1/XPC 7 BP GO:0019395 fatty acid oxidation 6/819 99/18670 0.2676 0.4884 0.3746 ECI1/AUH/HADH/PEX7/MTOR/ETFB 6 BP GO:0043403 skeletal muscle tissue regeneration 3/819 41/18670 0.2676 0.4884 0.3746 FZD7/GJA1/SGCA 3 BP GO:0044091 membrane biogenesis 3/819 41/18670 0.2676 0.4884 0.3746 EPHB2/CAV3/SPTBN1 3 BP GO:0045616 regulation of keratinocyte differentiation 3/819 41/18670 0.2676 0.4884 0.3746 VDR/FOXC1/ZFP36 3 BP GO:0050873 brown fat cell differentiation 3/819 41/18670 0.2676 0.4884 0.3746 RGS2/ITGA6/MTOR 3 BP GO:0060119 inner ear receptor cell development 3/819 41/18670 0.2676 0.4884 0.3746 NAGLU/FZD2/SDC4 3 BP GO:0070317 negative regulation of G0 to G1 transition 3/819 41/18670 0.2676 0.4884 0.3746 YAF2/RRM2/RYBP 3 BP GO:0150077 regulation of neuroinflammatory response 3/819 41/18670 0.2676 0.4884 0.3746 CTSC/GRN/NUPR1 3 BP GO:0002703 regulation of leukocyte mediated immunity 11/819 201/18670 0.2687 0.4898 0.3757 THOC1/IL18R1/MICB/IL12A/ITGB2/ABR/IL13RA2/ARRB2/RSAD2/IL4R/DNASE1L3 11 BP GO:0042267 natural killer cell mediated cytotoxicity 4/819 60/18670 0.269 0.4898 0.3757 MICB/IL12A/LYST/ARRB2 4 BP GO:0043966 histone H3 acetylation 4/819 60/18670 0.269 0.4898 0.3757 KAT2B/POLE3/WBP2/JADE2 4 BP GO:0046324 regulation of glucose import 4/819 60/18670 0.269 0.4898 0.3757 ENPP1/PIK3R1/GRB10/PTPN11 4 BP GO:0051306 mitotic sister chromatid separation 4/819 60/18670 0.269 0.4898 0.3757 ESPL1/PPP2R1A/ANAPC15/IK 4 BP GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 4/819 60/18670 0.269 0.4898 0.3757 HIP1R/NMT1/BAD/BCL2 4 BP GO:0032680 regulation of tumor necrosis factor production 9/819 160/18670 0.2698 0.4913 0.3768 THBS1/ANGPT1/PIK3R1/UBE2J1/ARRB2/JAK2/GAS6/ZFP36/PTPN11 9 BP GO:0031330 negative regulation of cellular catabolic process 14/819 264/18670 0.2708 0.4928 0.3779 CTSA/NUPR1/HNRNPA0/FBP1/MET/CLEC16A/UBE2J1/STAT3/ZFP36/MTOR/BCL2/HTR2B/MAP1A/RYBP 14 BP GO:0043462 regulation of ATPase activity 5/819 80/18670 0.274 0.4983 0.3821 TPM2/HSPA2/TPM1/NAPA/ATP1B1 5 BP GO:1900046 regulation of hemostasis 5/819 80/18670 0.274 0.4983 0.3821 THBS1/PRKCA/COMP/FAP/PDGFA 5 BP GO:0072089 stem cell proliferation 7/819 120/18670 0.2744 0.4989 0.3826 VEGFC/SOX5/SNAI2/ETV6/HIF1A/TEAD3/EML1 7 BP GO:0002440 production of molecular mediator of immune response 15/819 286/18670 0.2751 0.4999 0.3834 MAPK3/CD55/THOC1/IL18R1/ANGPT1/IL12A/TNFRSF14/IL13RA2/TGFB2/GAS6/RSAD2/IL4R/HLA-DQB1/TCIRG1/PKN1 15 BP GO:0001947 heart looping 4/819 61/18670 0.2788 0.5062 0.3882 MICAL2/GJA1/HIF1A/TMED2 4 BP GO:0030888 regulation of B cell proliferation 4/819 61/18670 0.2788 0.5062 0.3882 BST1/BCL2/PAWR/PKN1 4 BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 4/819 61/18670 0.2788 0.5062 0.3882 CD55/SOCS5/IL4R/HLX 4 BP GO:0006284 base-excision repair 3/819 42/18670 0.2797 0.5065 0.3884 MBD4/RPA3/HMGA1 3 BP GO:0006654 phosphatidic acid biosynthetic process 3/819 42/18670 0.2797 0.5065 0.3884 ABHD5/GPD1L/AGPAT1 3 BP GO:0031641 regulation of myelination 3/819 42/18670 0.2797 0.5065 0.3884 CTSC/FIG4/MTOR 3 BP GO:0042149 cellular response to glucose starvation 3/819 42/18670 0.2797 0.5065 0.3884 HSPA5/PIK3C3/BCL2 3 BP GO:0042181 ketone biosynthetic process 3/819 42/18670 0.2797 0.5065 0.3884 FDXR/COQ9/TPI1 3 BP GO:0044088 regulation of vacuole organization 3/819 42/18670 0.2797 0.5065 0.3884 GRN/NUPR1/PIKFYVE 3 BP GO:0051154 negative regulation of striated muscle cell differentiation 3/819 42/18670 0.2797 0.5065 0.3884 FZD7/CAV3/RGS2 3 BP GO:1903146 regulation of autophagy of mitochondrion 3/819 42/18670 0.2797 0.5065 0.3884 HAX1/HIF1A/CLEC16A 3 BP GO:0044839 cell cycle G2/M phase transition 14/819 266/18670 0.2799 0.5067 0.3886 PSMD8/HAUS7/PSMB7/PSMD1/HSPA2/PSMB6/SYF2/ENSA/PLCB1/PPP2R1A/PSMD3/CKAP5/PSMD2/PSMB8 14 BP GO:0016126 sterol biosynthetic process 5/819 81/18670 0.2825 0.5094 0.3907 TM7SF2/ABCG1/LBR/MBTPS1/NFYB 5 BP GO:0032204 regulation of telomere maintenance 5/819 81/18670 0.2825 0.5094 0.3907 MAPK3/MAP3K4/NEK7/TERF2/CCT7 5 BP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 5/819 81/18670 0.2825 0.5094 0.3907 USP5/RAD23A/RNF144A/SOCS5/RCHY1 5 BP GO:1902930 regulation of alcohol biosynthetic process 5/819 81/18670 0.2825 0.5094 0.3907 VDR/TM7SF2/ABCG1/MBTPS1/NFYB 5 BP GO:0032649 regulation of interferon-gamma production 6/819 101/18670 0.2828 0.5094 0.3907 IL18R1/ISG15/IL12A/PDE4B/GAS6/HLA-DPB1 6 BP GO:0034440 lipid oxidation 6/819 101/18670 0.2828 0.5094 0.3907 ECI1/AUH/HADH/PEX7/MTOR/ETFB 6 BP GO:0097006 regulation of plasma lipoprotein particle levels 6/819 101/18670 0.2828 0.5094 0.3907 BMP1/ABCG1/PLTP/LIPA/AP2B1/VLDLR 6 BP GO:0021953 central nervous system neuron differentiation 10/819 183/18670 0.2834 0.5094 0.3907 CDH11/SATB2/EPHB2/ADARB1/NTRK2/NRP1/UQCRQ/NRP2/FZD1/SOX4 10 BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 10/819 183/18670 0.2834 0.5094 0.3907 SLC20A1/GJA1/PRKD1/TGM2/TRIM25/S100A13/PRKCB/UBE2I/LPAR1/HTR2B 10 BP GO:0050770 regulation of axonogenesis 10/819 183/18670 0.2834 0.5094 0.3907 TRAK2/CXCL12/EPHB2/NTRK2/PLXND1/NRP1/CHN1/TWF2/THY1/PLXNC1 10 BP GO:0001919 regulation of receptor recycling 2/819 24/18670 0.284 0.5094 0.3907 RAB29/VAMP3 2 BP GO:0003181 atrioventricular valve morphogenesis 2/819 24/18670 0.284 0.5094 0.3907 TGFB2/SOX4 2 BP GO:0003351 epithelial cilium movement 2/819 24/18670 0.284 0.5094 0.3907 RFX3/SPA17 2 BP GO:0009218 pyrimidine ribonucleotide metabolic process 2/819 24/18670 0.284 0.5094 0.3907 NME3/CTPS1 2 BP GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway 2/819 24/18670 0.284 0.5094 0.3907 HIP1R/LOX 2 BP GO:0031579 membrane raft organization 2/819 24/18670 0.284 0.5094 0.3907 GSN/CAV3 2 BP GO:0033119 negative regulation of RNA splicing 2/819 24/18670 0.284 0.5094 0.3907 SAP18/SRSF7 2 BP GO:0034162 toll-like receptor 9 signaling pathway 2/819 24/18670 0.284 0.5094 0.3907 PIK3C3/RSAD2 2 BP GO:0036010 protein localization to endosome 2/819 24/18670 0.284 0.5094 0.3907 NRP1/EZR 2 BP GO:0043302 positive regulation of leukocyte degranulation 2/819 24/18670 0.284 0.5094 0.3907 ITGB2/IL4R 2 BP GO:0046135 pyrimidine nucleoside catabolic process 2/819 24/18670 0.284 0.5094 0.3907 APOBEC3B/APOBEC3C 2 BP GO:0046426 negative regulation of JAK-STAT cascade 2/819 24/18670 0.284 0.5094 0.3907 SOCS3/PPP2R1A 2 BP GO:0050996 positive regulation of lipid catabolic process 2/819 24/18670 0.284 0.5094 0.3907 ABHD5/PNPLA2 2 BP GO:0051905 establishment of pigment granule localization 2/819 24/18670 0.284 0.5094 0.3907 RAB27B/MYO5A 2 BP GO:0071677 positive regulation of mononuclear cell migration 2/819 24/18670 0.284 0.5094 0.3907 CXCL12/CCR1 2 BP GO:0090103 cochlea morphogenesis 2/819 24/18670 0.284 0.5094 0.3907 PTK7/FZD2 2 BP GO:0099590 neurotransmitter receptor internalization 2/819 24/18670 0.284 0.5094 0.3907 ITGB3/AP2B1 2 BP GO:1903010 regulation of bone development 2/819 24/18670 0.284 0.5094 0.3907 GREM1/LOX 2 BP GO:0034764 positive regulation of transmembrane transport 11/819 204/18670 0.2844 0.5099 0.3911 GSTO1/CEMIP/EPHB2/PIK3R1/HSPA2/THY1/ATP1B1/STAC/KCNMB1/PTPN11/TRPC6 11 BP GO:0072331 signal transduction by p53 class mediator 14/819 267/18670 0.2845 0.5099 0.3911 PIN1/NUPR1/RFC3/SNAI2/RPA3/PRMT1/RRS1/PTTG1IP/USP10/HEXIM1/BCL2/PDK2/FOXO3/SOX4 14 BP GO:0002449 lymphocyte mediated immunity 18/819 352/18670 0.285 0.5107 0.3916 CD55/THOC1/IL18R1/CTSC/MICB/CD70/IL12A/C1S/LYST/IL13RA2/ARRB2/C1R/RSAD2/IL4R/IGLL1/HLA-DQB1/IRF7/TCIRG1 18 BP GO:0038094 Fc-gamma receptor signaling pathway 8/819 142/18670 0.2852 0.5108 0.3917 MAPK3/PIK3R1/MYO10/ARPC1B/PIK3R2/PIK3CB/RAPGEF1/NCK1 8 BP GO:0008202 steroid metabolic process 17/819 331/18670 0.2862 0.5125 0.3931 VDR/TM7SF2/IGFBP7/CYP1B1/ABCG1/FDXR/LBR/SNAI2/CYP3A4/CYP27A1/LIPA/ASAH1/SULT2B1/MBTPS1/CAT/VLDLR/NFYB 17 BP GO:0000209 protein polyubiquitination 16/819 310/18670 0.2874 0.5144 0.3945 SIAH2/PSMD8/PSMB7/PSMD1/UBOX5/SASH1/UBE2G1/RNF144A/PSMB6/RMND5A/IFI27/BCL2/UBE2E1/PSMD3/PSMD2/PSMB8 16 BP GO:0032640 tumor necrosis factor production 9/819 163/18670 0.2876 0.5145 0.3945 THBS1/ANGPT1/PIK3R1/UBE2J1/ARRB2/JAK2/GAS6/ZFP36/PTPN11 9 BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 9/819 163/18670 0.2876 0.5145 0.3945 THBS1/ANGPT1/PIK3R1/UBE2J1/ARRB2/JAK2/GAS6/ZFP36/PTPN11 9 BP GO:0007585 respiratory gaseous exchange 4/819 62/18670 0.2887 0.5156 0.3954 ELN/COX5B/KDM6A/EDNRA 4 BP GO:0051898 negative regulation of protein kinase B signaling 4/819 62/18670 0.2887 0.5156 0.3954 CIB1/RAPGEF1/ARRB2/KLF4 4 BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 4/819 62/18670 0.2887 0.5156 0.3954 BCL2L1/MAP3K5/BCL2/NCK1 4 BP GO:1902305 regulation of sodium ion transmembrane transport 4/819 62/18670 0.2887 0.5156 0.3954 SNTA1/CAV3/ATP1B1/GPD1L 4 BP GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 4/819 62/18670 0.2887 0.5156 0.3954 HIP1R/NMT1/BAD/BCL2 4 BP GO:0030098 lymphocyte differentiation 18/819 353/18670 0.289 0.516 0.3957 IL18R1/KLF6/FZD7/BMP4/PIK3R1/IL12A/STAT3/GAS6/RSAD2/SOCS5/IL4R/MTOR/BAD/BCL2/TCIRG1/SOX4/ITGB1/HLX 18 BP GO:0015711 organic anion transport 24/819 482/18670 0.2897 0.5171 0.3966 SLC35D2/CTNS/ATP8A1/SLC7A8/SLC4A4/THBS1/CLN3/ABCG1/FOLR3/PPFIA4/FOLR2/GJA1/NTRK2/SV2A/SLC1A5/SLC4A3/ATP11B/ABCC4/PLTP/KCNN4/RGS2/UNC13B/MFSD10/PER2 24 BP GO:0090150 establishment of protein localization to membrane 17/819 332/18670 0.2904 0.518 0.3973 CEMIP/HSPA5/ITGB2/SSR2/CIB1/ICMT/CD24/NMT1/ATP1B1/ITGB1BP1/RAB8A/CLIP1/BAD/BCL2/KRT18/SPTBN1/VAMP3 17 BP GO:0016925 protein sumoylation 5/819 82/18670 0.291 0.518 0.3973 RANGAP1/NUP205/NUP93/NUP153/UBE2I 5 BP GO:0034644 cellular response to UV 5/819 82/18670 0.291 0.518 0.3973 PIK3R1/PTPRK/CASP9/XPC/CREBBP 5 BP GO:0051702 interaction with symbiont 5/819 82/18670 0.291 0.518 0.3973 PPIB/CHD1/IFI27/FBXL2/PTX3 5 BP GO:0090049 regulation of cell migration involved in sprouting angiogenesis 5/819 82/18670 0.291 0.518 0.3973 THBS1/CIB1/NRP1/KLF4/ITGB1BP1 5 BP GO:0000413 protein peptidyl-prolyl isomerization 3/819 43/18670 0.2918 0.518 0.3973 PIN1/FKBP4/PPIB 3 BP GO:0000959 mitochondrial RNA metabolic process 3/819 43/18670 0.2918 0.518 0.3973 MTERF1/FOXO3/POLRMT 3 BP GO:0021795 cerebral cortex cell migration 3/819 43/18670 0.2918 0.518 0.3973 LAMB1/NRP1/NRP2 3 BP GO:0031279 regulation of cyclase activity 3/819 43/18670 0.2918 0.518 0.3973 MAPK3/PALM/CACNA1C 3 BP GO:0032881 regulation of polysaccharide metabolic process 3/819 43/18670 0.2918 0.518 0.3973 ENPP1/HAS2/MTOR 3 BP GO:0032924 activin receptor signaling pathway 3/819 43/18670 0.2918 0.518 0.3973 TGIF2/TGFBR1/INHBB 3 BP GO:0045687 positive regulation of glial cell differentiation 3/819 43/18670 0.2918 0.518 0.3973 IL6ST/MTOR/BIN1 3 BP GO:0045773 positive regulation of axon extension 3/819 43/18670 0.2918 0.518 0.3973 CXCL12/NRP1/TWF2 3 BP GO:0046473 phosphatidic acid metabolic process 3/819 43/18670 0.2918 0.518 0.3973 ABHD5/GPD1L/AGPAT1 3 BP GO:0051293 establishment of spindle localization 3/819 43/18670 0.2918 0.518 0.3973 ESPL1/NSFL1C/MYH9 3 BP GO:0099054 presynapse assembly 3/819 43/18670 0.2918 0.518 0.3973 IL1RAP/GPC4/FZD1 3 BP GO:0018205 peptidyl-lysine modification 20/819 397/18670 0.2937 0.5212 0.3997 MAPK3/RANGAP1/KAT2B/TGM2/NDUFAB1/POLE3/SETD1B/SNAI2/LOX/WBP2/NUP205/USPL1/NUP93/NUP153/LOXL2/JADE2/UBE2I/KDM6A/SOX4/CREBBP 20 BP GO:0009116 nucleoside metabolic process 7/819 123/18670 0.2952 0.5237 0.4016 NME3/APOBEC3B/PRPSAP2/TK2/GUK1/APOBEC3C/CTPS1 7 BP GO:1904064 positive regulation of cation transmembrane transport 8/819 144/18670 0.298 0.5277 0.4047 GSTO1/CEMIP/EPHB2/HSPA2/THY1/ATP1B1/STAC/KCNMB1 8 BP GO:0002637 regulation of immunoglobulin production 4/819 63/18670 0.2986 0.5277 0.4047 THOC1/IL13RA2/IL4R/PKN1 4 BP GO:0006893 Golgi to plasma membrane transport 4/819 63/18670 0.2986 0.5277 0.4047 ARF4/KRT18/SPTBN1/VAMP3 4 BP GO:0007062 sister chromatid cohesion 4/819 63/18670 0.2986 0.5277 0.4047 ESPL1/POGZ/SMC5/PPP2R1A 4 BP GO:0032371 regulation of sterol transport 4/819 63/18670 0.2986 0.5277 0.4047 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0032374 regulation of cholesterol transport 4/819 63/18670 0.2986 0.5277 0.4047 ABCG1/NR1H2/NR1H3/PLTP 4 BP GO:0090181 regulation of cholesterol metabolic process 4/819 63/18670 0.2986 0.5277 0.4047 TM7SF2/ABCG1/MBTPS1/NFYB 4 BP GO:0019318 hexose metabolic process 13/819 249/18670 0.2994 0.5277 0.4047 ENPP1/SORD/OAS1/KAT2B/FBP1/PDK1/MTOR/BAD/PDK2/PGM1/PER2/TPI1/MDH2 13 BP GO:0045582 positive regulation of T cell differentiation 5/819 83/18670 0.2996 0.5277 0.4047 IL12A/SOCS5/IL4R/BAD/HLX 5 BP GO:0048145 regulation of fibroblast proliferation 5/819 83/18670 0.2996 0.5277 0.4047 NUPR1/PDGFA/DDR2/GAS6/PAWR 5 BP GO:0001945 lymph vessel development 2/819 25/18670 0.3005 0.5277 0.4047 FOXC1/VEGFC 2 BP GO:0002719 negative regulation of cytokine production involved in immune response 2/819 25/18670 0.3005 0.5277 0.4047 ANGPT1/TGFB2 2 BP GO:0007026 negative regulation of microtubule depolymerization 2/819 25/18670 0.3005 0.5277 0.4047 CIB1/CAMSAP2 2 BP GO:0019430 removal of superoxide radicals 2/819 25/18670 0.3005 0.5277 0.4047 SOD3/FBLN5 2 BP GO:0031069 hair follicle morphogenesis 2/819 25/18670 0.3005 0.5277 0.4047 TGFB2/BCL2 2 BP GO:0032104 regulation of response to extracellular stimulus 2/819 25/18670 0.3005 0.5277 0.4047 SNAI2/MTOR 2 BP GO:0032107 regulation of response to nutrient levels 2/819 25/18670 0.3005 0.5277 0.4047 SNAI2/MTOR 2 BP GO:0032400 melanosome localization 2/819 25/18670 0.3005 0.5277 0.4047 RAB27B/MYO5A 2 BP GO:0032509 endosome transport via multivesicular body sorting pathway 2/819 25/18670 0.3005 0.5277 0.4047 LYST/CHMP2A 2 BP GO:0035336 long-chain fatty-acyl-CoA metabolic process 2/819 25/18670 0.3005 0.5277 0.4047 ELOVL2/TECR 2 BP GO:0043951 negative regulation of cAMP-mediated signaling 2/819 25/18670 0.3005 0.5277 0.4047 RGS2/LPAR1 2 BP GO:0046755 viral budding 2/819 25/18670 0.3005 0.5277 0.4047 CHMP2A/TSG101 2 BP GO:0046856 phosphatidylinositol dephosphorylation 2/819 25/18670 0.3005 0.5277 0.4047 SYNJ2/INPP5E 2 BP GO:0050901 leukocyte tethering or rolling 2/819 25/18670 0.3005 0.5277 0.4047 CXCL12/ITGB1 2 BP GO:0051654 establishment of mitochondrion localization 2/819 25/18670 0.3005 0.5277 0.4047 TRAK2/HIF1A 2 BP GO:0061217 regulation of mesonephros development 2/819 25/18670 0.3005 0.5277 0.4047 MAGED1/BMP4 2 BP GO:0072202 cell differentiation involved in metanephros development 2/819 25/18670 0.3005 0.5277 0.4047 BMP4/WWTR1 2 BP GO:0097186 amelogenesis 2/819 25/18670 0.3005 0.5277 0.4047 ITGA6/TCIRG1 2 BP GO:1903306 negative regulation of regulated secretory pathway 2/819 25/18670 0.3005 0.5277 0.4047 ABR/IL13RA2 2 BP GO:1905809 negative regulation of synapse organization 2/819 25/18670 0.3005 0.5277 0.4047 ARHGEF15/GRIN2B 2 BP GO:2000353 positive regulation of endothelial cell apoptotic process 2/819 25/18670 0.3005 0.5277 0.4047 THBS1/FOXO3 2 BP GO:2000679 positive regulation of transcription regulatory region DNA binding 2/819 25/18670 0.3005 0.5277 0.4047 FOXC1/KLF4 2 BP GO:0009410 response to xenobiotic stimulus 15/819 292/18670 0.3018 0.5298 0.4063 GSTO1/CYP1B1/ADCY8/HSPA5/FMO1/GHR/FMO3/CYP3A4/RGS2/MTOR/FMO2/ASIC1/CASP9/FOXO3/GRIN2A 15 BP GO:0046717 acid secretion 7/819 124/18670 0.3022 0.53 0.4065 HIP1R/PPFIA4/NTRK2/SV2A/SLC1A5/ABCC4/UNC13B 7 BP GO:0051101 regulation of DNA binding 7/819 124/18670 0.3022 0.53 0.4065 TXN/FOXC1/HABP4/KLF4/JAK2/ITGA2/PER2 7 BP GO:0008544 epidermis development 23/819 464/18670 0.3024 0.5303 0.4067 SFRP4/VDR/ATP2A2/BMP4/FOXC1/PALLD/MYO5A/FZD6/COL7A1/PDGFA/FLNB/TGFB2/KLF4/CAPNS1/ZFP36/ASAH1/TSG101/SPRR2D/BCL2/SULT2B1/KRT18/PIP5K1A/NAB1 23 BP GO:0007080 mitotic metaphase plate congression 3/819 44/18670 0.3039 0.5311 0.4073 RRS1/CHMP2A/KIF2C 3 BP GO:0007212 dopamine receptor signaling pathway 3/819 44/18670 0.3039 0.5311 0.4073 GNB5/PALM/ARRB2 3 BP GO:0010463 mesenchymal cell proliferation 3/819 44/18670 0.3039 0.5311 0.4073 BMP4/PDGFA/WNT11 3 BP GO:0014003 oligodendrocyte development 3/819 44/18670 0.3039 0.5311 0.4073 PLP1/GSN/LPAR1 3 BP GO:0014047 glutamate secretion 3/819 44/18670 0.3039 0.5311 0.4073 PPFIA4/NTRK2/UNC13B 3 BP GO:0033046 negative regulation of sister chromatid segregation 3/819 44/18670 0.3039 0.5311 0.4073 ESPL1/ANAPC15/IK 3 BP GO:0034105 positive regulation of tissue remodeling 3/819 44/18670 0.3039 0.5311 0.4073 VDR/PLEKHM1/PRKCA 3 BP GO:0042269 regulation of natural killer cell mediated cytotoxicity 3/819 44/18670 0.3039 0.5311 0.4073 MICB/IL12A/ARRB2 3 BP GO:0060999 positive regulation of dendritic spine development 3/819 44/18670 0.3039 0.5311 0.4073 LPAR1/MTOR/CAMK1 3 BP GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 3/819 44/18670 0.3039 0.5311 0.4073 THBS1/KLF4/ITGB1BP1 3 BP GO:1903214 regulation of protein targeting to mitochondrion 3/819 44/18670 0.3039 0.5311 0.4073 VPS11/HAX1/LMAN1 3 BP GO:0010951 negative regulation of endopeptidase activity 13/819 250/18670 0.3043 0.5316 0.4077 RENBP/CRYAB/SIAH2/THBS1/SERPINH1/LAMTOR5/COL6A3/COL7A1/SERPINB6/ARRB2/KLF4/GAS6/BIN1 13 BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 8/819 145/18670 0.3045 0.5316 0.4077 MAPK3/PIK3R1/MYO10/ARPC1B/PIK3R2/PIK3CB/RAPGEF1/NCK1 8 BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 8/819 145/18670 0.3045 0.5316 0.4077 THOC1/IL18R1/IL12A/RSAD2/SOCS5/IL4R/PKN1/HLX 8 BP GO:0019233 sensory perception of pain 6/819 104/18670 0.3058 0.5331 0.4088 MAPK3/CXCL12/ARRB2/MTOR/ITGA2/GRIN2A 6 BP GO:0030593 neutrophil chemotaxis 6/819 104/18670 0.3058 0.5331 0.4088 THBS4/ITGA1/ITGB2/PDE4B/BST1/TGFB2 6 BP GO:0032414 positive regulation of ion transmembrane transporter activity 6/819 104/18670 0.3058 0.5331 0.4088 GSTO1/EPHB2/HSPA2/ATP1B1/STAC/TRPC6 6 BP GO:1901800 positive regulation of proteasomal protein catabolic process 6/819 104/18670 0.3058 0.5331 0.4088 USP5/RAD23A/NUPR1/RNF144A/SOCS5/RCHY1 6 BP GO:0048144 fibroblast proliferation 5/819 84/18670 0.3083 0.5372 0.412 NUPR1/PDGFA/DDR2/GAS6/PAWR 5 BP GO:0002228 natural killer cell mediated immunity 4/819 64/18670 0.3086 0.5372 0.412 MICB/IL12A/LYST/ARRB2 4 BP GO:0045600 positive regulation of fat cell differentiation 4/819 64/18670 0.3086 0.5372 0.412 ADIRF/RARRES2/SNAI2/ZFP36 4 BP GO:0045670 regulation of osteoclast differentiation 4/819 64/18670 0.3086 0.5372 0.412 PIK3R1/RASSF2/CCR1/MTOR 4 BP GO:0046579 positive regulation of Ras protein signal transduction 4/819 64/18670 0.3086 0.5372 0.412 COL3A1/RAPGEF1/JAK2/LPAR1 4 BP GO:0006805 xenobiotic metabolic process 7/819 125/18670 0.3092 0.5379 0.4125 GSTO1/CYP1B1/FMO1/GHR/FMO3/CYP3A4/FMO2 7 BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7/819 125/18670 0.3092 0.5379 0.4125 NACC2/PRMT1/KLF4/BCL2/SOX4/CTDSP2/CDKN2A 7 BP GO:0051346 negative regulation of hydrolase activity 23/819 466/18670 0.3096 0.5384 0.4129 RENBP/CRYAB/SIAH2/THBS1/SERPINH1/IQGAP1/LAMTOR5/IFIT1/COL6A3/COL7A1/ARL2/SERPINB6/TGFB2/ARRB2/KLF4/RGS2/TERF2/GAS6/ENSA/CSRNP2/BIN1/PTX3/TMED2 23 BP GO:0061337 cardiac conduction 8/819 146/18670 0.311 0.5407 0.4146 ATP2A2/GJA1/GJC1/KCND3/ITPR3/ATP1B1/CACNA1C/BIN1 8 BP GO:1901568 fatty acid derivative metabolic process 9/819 167/18670 0.3117 0.5418 0.4155 MAPK3/GGT5/OXCT1/CYP1B1/HMGCL/PLA2G4C/ELOVL2/GPX4/TECR 9 BP GO:0002821 positive regulation of adaptive immune response 6/819 105/18670 0.3135 0.5445 0.4176 IL18R1/IL12A/RSAD2/SOCS5/IL6ST/HLX 6 BP GO:0015748 organophosphate ester transport 6/819 105/18670 0.3135 0.5445 0.4176 ATP8A1/ABCG1/GJA1/ATP11B/PLTP/KCNN4 6 BP GO:0002820 negative regulation of adaptive immune response 3/819 45/18670 0.3161 0.5456 0.4184 THOC1/TNFRSF14/IL4R 3 BP GO:0044275 cellular carbohydrate catabolic process 3/819 45/18670 0.3161 0.5456 0.4184 SORD/PGM1/TPI1 3 BP GO:0048255 mRNA stabilization 3/819 45/18670 0.3161 0.5456 0.4184 HNRNPA0/ZFP36/MTOR 3 BP GO:0051985 negative regulation of chromosome segregation 3/819 45/18670 0.3161 0.5456 0.4184 ESPL1/ANAPC15/IK 3 BP GO:0070316 regulation of G0 to G1 transition 3/819 45/18670 0.3161 0.5456 0.4184 YAF2/RRM2/RYBP 3 BP GO:0071827 plasma lipoprotein particle organization 3/819 45/18670 0.3161 0.5456 0.4184 BMP1/ABCG1/PLTP 3 BP GO:0090278 negative regulation of peptide hormone secretion 3/819 45/18670 0.3161 0.5456 0.4184 INHBB/HADH/PTPN11 3 BP GO:0001556 oocyte maturation 2/819 26/18670 0.3169 0.5456 0.4184 PPP2R1A/FOXO3 2 BP GO:0003171 atrioventricular valve development 2/819 26/18670 0.3169 0.5456 0.4184 TGFB2/SOX4 2 BP GO:0006817 phosphate ion transport 2/819 26/18670 0.3169 0.5456 0.4184 SFRP4/SLC20A1 2 BP GO:0010460 positive regulation of heart rate 2/819 26/18670 0.3169 0.5456 0.4184 ATP2A2/TPM1 2 BP GO:0022011 myelination in peripheral nervous system 2/819 26/18670 0.3169 0.5456 0.4184 MYOC/NTRK2 2 BP GO:0031645 negative regulation of neurological system process 2/819 26/18670 0.3169 0.5456 0.4184 CTSC/FIG4 2 BP GO:0032292 peripheral nervous system axon ensheathment 2/819 26/18670 0.3169 0.5456 0.4184 MYOC/NTRK2 2 BP GO:0033561 regulation of water loss via skin 2/819 26/18670 0.3169 0.5456 0.4184 CLDN4/MET 2 BP GO:0034114 regulation of heterotypic cell-cell adhesion 2/819 26/18670 0.3169 0.5456 0.4184 THY1/KLF4 2 BP GO:0035640 exploration behavior 2/819 26/18670 0.3169 0.5456 0.4184 CHL1/ITGA3 2 BP GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 2/819 26/18670 0.3169 0.5456 0.4184 IGFBP1/IGFBP6 2 BP GO:0048169 regulation of long-term neuronal synaptic plasticity 2/819 26/18670 0.3169 0.5456 0.4184 EPHB2/RAB8A 2 BP GO:0051497 negative regulation of stress fiber assembly 2/819 26/18670 0.3169 0.5456 0.4184 MYOC/MET 2 BP GO:0051875 pigment granule localization 2/819 26/18670 0.3169 0.5456 0.4184 RAB27B/MYO5A 2 BP GO:0060074 synapse maturation 2/819 26/18670 0.3169 0.5456 0.4184 PALM/ARHGEF15 2 BP GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 2/819 26/18670 0.3169 0.5456 0.4184 GSTO1/CLIC2 2 BP GO:0071377 cellular response to glucagon stimulus 2/819 26/18670 0.3169 0.5456 0.4184 ADCY8/ADCY7 2 BP GO:0080111 DNA demethylation 2/819 26/18670 0.3169 0.5456 0.4184 APOBEC3B/APOBEC3C 2 BP GO:0097066 response to thyroid hormone 2/819 26/18670 0.3169 0.5456 0.4184 LMO2/GCLM 2 BP GO:1903203 regulation of oxidative stress-induced neuron death 2/819 26/18670 0.3169 0.5456 0.4184 HIF1A/FZD1 2 BP GO:1905048 regulation of metallopeptidase activity 2/819 26/18670 0.3169 0.5456 0.4184 MAPK3/STAT3 2 BP GO:0061351 neural precursor cell proliferation 8/819 147/18670 0.3175 0.5464 0.4191 VEGFC/SOX5/HIF1A/FZD6/TEAD3/RAPGEF1/FOXO3/EML1 8 BP GO:0050806 positive regulation of synaptic transmission 9/819 168/18670 0.3178 0.5464 0.4191 ADCY8/EPHB2/NTRK2/ITPR3/ARRB2/GRIN2B/UNC13B/ROR2/GRIN2A 9 BP GO:0071706 tumor necrosis factor superfamily cytokine production 9/819 168/18670 0.3178 0.5464 0.4191 THBS1/ANGPT1/PIK3R1/UBE2J1/ARRB2/JAK2/GAS6/ZFP36/PTPN11 9 BP GO:1990138 neuron projection extension 9/819 168/18670 0.3178 0.5464 0.4191 SH3GL2/CXCL12/POSTN/IQGAP1/NRP1/SPG11/TWF2/NRP2/ITGB1 9 BP GO:0032729 positive regulation of interferon-gamma production 4/819 65/18670 0.3186 0.5473 0.4197 IL18R1/IL12A/PDE4B/HLA-DPB1 4 BP GO:0048663 neuron fate commitment 4/819 65/18670 0.3186 0.5473 0.4197 SATB2/BMP4/TGFBR1/NOTCH3 4 BP GO:0060675 ureteric bud morphogenesis 4/819 65/18670 0.3186 0.5473 0.4197 MAGED1/BMP4/WNT11/BCL2 4 BP GO:0002286 T cell activation involved in immune response 6/819 106/18670 0.3213 0.5516 0.4231 IL18R1/STAT3/SOCS5/IL4R/MTOR/HLX 6 BP GO:0140056 organelle localization by membrane tethering 9/819 169/18670 0.324 0.5558 0.4262 HAUS7/ESYT1/VPS11/RAB8A/UNC13B/PPP2R1A/VPS45/CKAP5/VAMP3 9 BP GO:0008643 carbohydrate transport 8/819 148/18670 0.3241 0.5558 0.4262 ENPP1/SLC35D2/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11/EZR 8 BP GO:0051592 response to calcium ion 8/819 148/18670 0.3241 0.5558 0.4262 THBS1/SPARC/ADCY8/HSPA5/IQGAP1/ITPR3/BAD/KCNMB1 8 BP GO:0061041 regulation of wound healing 8/819 148/18670 0.3241 0.5558 0.4262 THBS1/PRKCA/GJA1/MYH9/MYLK/FAP/PDGFA/MTOR 8 BP GO:0001942 hair follicle development 5/819 86/18670 0.3257 0.5581 0.4281 MYO5A/FZD6/PDGFA/TGFB2/BCL2 5 BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 5/819 86/18670 0.3257 0.5581 0.4281 THBS1/PIK3R1/BCL2L1/BAD/BCL2 5 BP GO:0002715 regulation of natural killer cell mediated immunity 3/819 46/18670 0.3282 0.5611 0.4303 MICB/IL12A/ARRB2 3 BP GO:0031648 protein destabilization 3/819 46/18670 0.3282 0.5611 0.4303 RAD23A/GSN/CREBBP 3 BP GO:0032480 negative regulation of type I interferon production 3/819 46/18670 0.3282 0.5611 0.4303 PIN1/ISG15/TRIM25 3 BP GO:0044003 modification by symbiont of host morphology or physiology 3/819 46/18670 0.3282 0.5611 0.4303 BCL2L1/BAD/KPNA3 3 BP GO:0050919 negative chemotaxis 3/819 46/18670 0.3282 0.5611 0.4303 ITGB3/PDGFA/NRP2 3 BP GO:0099172 presynapse organization 3/819 46/18670 0.3282 0.5611 0.4303 IL1RAP/GPC4/FZD1 3 BP GO:0015800 acidic amino acid transport 4/819 66/18670 0.3287 0.5611 0.4303 PPFIA4/NTRK2/UNC13B/PER2 4 BP GO:0021872 forebrain generation of neurons 4/819 66/18670 0.3287 0.5611 0.4303 SATB2/NRP1/UQCRQ/NRP2 4 BP GO:0051785 positive regulation of nuclear division 4/819 66/18670 0.3287 0.5611 0.4303 ESPL1/NSFL1C/SMC5/PLCB1 4 BP GO:0072171 mesonephric tubule morphogenesis 4/819 66/18670 0.3287 0.5611 0.4303 MAGED1/BMP4/WNT11/BCL2 4 BP GO:1901607 alpha-amino acid biosynthetic process 4/819 66/18670 0.3287 0.5611 0.4303 PYCR1/SERINC5/MTHFD1/BCAT2 4 BP GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 4/819 66/18670 0.3287 0.5611 0.4303 HIP1R/NMT1/BAD/BCL2 4 BP GO:0019080 viral gene expression 10/819 191/18670 0.329 0.5611 0.4303 POLR2L/POLR2E/MDFIC/NUP205/NUP93/NUP153/SUPT4H1/ZFP36/SEC13/CHD1 10 BP GO:0001909 leukocyte mediated cytotoxicity 6/819 107/18670 0.3291 0.5611 0.4303 CTSC/MICB/IL12A/LYST/ARRB2/DNASE1L3 6 BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 6/819 107/18670 0.3291 0.5611 0.4303 SNAI2/PRMT1/PTTG1IP/USP10/FOXO3/SOX4 6 BP GO:0051341 regulation of oxidoreductase activity 6/819 107/18670 0.3291 0.5611 0.4303 VDR/DDAH2/HIF1A/CAV3/TERF2/HTR2B 6 BP GO:0002758 innate immune response-activating signal transduction 15/819 298/18670 0.3293 0.5612 0.4304 MAPKAPK3/PSMD8/PSMB7/PSMD1/ITGB2/NR1H3/PIK3C3/PSMB6/ARRB2/RSAD2/IRF7/PSMD3/PSMD2/PSMB8/CREBBP 15 BP GO:0044843 cell cycle G1/S phase transition 15/819 298/18670 0.3293 0.5612 0.4304 NACC2/PRIM2/CCND2/POLE3/RPA3/PRMT1/KLF4/PRIM1/RRM2/BCL2/PLCB1/SOX4/CTDSP2/CDKN2A/ITGB1 15 BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 8/819 149/18670 0.3307 0.5633 0.432 HIP1R/MAP3K5/GSN/JAK2/GRIN2B/BAD/CASP9/GRIN2A 8 BP GO:0000188 inactivation of MAPK activity 2/819 27/18670 0.3332 0.5651 0.4334 DUSP7/PPP2R1A 2 BP GO:0001964 startle response 2/819 27/18670 0.3332 0.5651 0.4334 GLRB/GRIN2A 2 BP GO:0006706 steroid catabolic process 2/819 27/18670 0.3332 0.5651 0.4334 CYP3A4/CYP27A1 2 BP GO:0006730 one-carbon metabolic process 2/819 27/18670 0.3332 0.5651 0.4334 MTHFD2/MTHFD1 2 BP GO:0006884 cell volume homeostasis 2/819 27/18670 0.3332 0.5651 0.4334 KCNN4/CLCN6 2 BP GO:0007176 regulation of epidermal growth factor-activated receptor activity 2/819 27/18670 0.3332 0.5651 0.4334 SOCS5/TSG101 2 BP GO:0022616 DNA strand elongation 2/819 27/18670 0.3332 0.5651 0.4334 RFC3/POLD2 2 BP GO:0036475 neuron death in response to oxidative stress 2/819 27/18670 0.3332 0.5651 0.4334 HIF1A/FZD1 2 BP GO:0045932 negative regulation of muscle contraction 2/819 27/18670 0.3332 0.5651 0.4334 RGS2/BIN1 2 BP GO:0048643 positive regulation of skeletal muscle tissue development 2/819 27/18670 0.3332 0.5651 0.4334 ARNTL/BCL2 2 BP GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 2/819 27/18670 0.3332 0.5651 0.4334 IL4R/CAMK1 2 BP GO:0060259 regulation of feeding behavior 2/819 27/18670 0.3332 0.5651 0.4334 STAT3/MTOR 2 BP GO:0071450 cellular response to oxygen radical 2/819 27/18670 0.3332 0.5651 0.4334 SOD3/FBLN5 2 BP GO:0071451 cellular response to superoxide 2/819 27/18670 0.3332 0.5651 0.4334 SOD3/FBLN5 2 BP GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2/819 27/18670 0.3332 0.5651 0.4334 HIF1A/TRAP1 2 BP GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 13/819 256/18670 0.3341 0.5664 0.4344 FPR1/PRKCA/ADCY8/RAMP2/ADCY7/CCR3/CCR1/PALM/RGS2/GABBR1/LPAR1/HTR2B/EDNRA 13 BP GO:0006112 energy reserve metabolic process 5/819 87/18670 0.3344 0.5664 0.4344 ENPP1/IL6ST/MTOR/PGM1/PER2 5 BP GO:0048477 oogenesis 5/819 87/18670 0.3344 0.5664 0.4344 INHBB/BCL2/PPP2R1A/PTX3/FOXO3 5 BP GO:0006402 mRNA catabolic process 18/819 364/18670 0.3344 0.5664 0.4344 PSMD8/PSMB7/PRKCA/EXOSC7/PSMD1/HNRNPA0/SAMD4A/TNRC6B/PSMB6/RNH1/ZFP36/EXOSC2/MTOR/PPP2R1A/PSMD3/LSM4/PSMD2/PSMB8 18 BP GO:0000910 cytokinesis 9/819 171/18670 0.3363 0.5693 0.4366 ESPL1/PIN1/KLHL21/BCL2L1/MYH9/PIK3C3/RASA1/CHMP2A/SPTBN1 9 BP GO:1904659 glucose transmembrane transport 6/819 108/18670 0.3369 0.5702 0.4373 ENPP1/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11 6 BP GO:0034754 cellular hormone metabolic process 7/819 129/18670 0.3376 0.5712 0.4381 CYP1B1/FDXR/ADH1C/CYP3A4/ADH1A/ADH1B/ALDH1A3 7 BP GO:0003143 embryonic heart tube morphogenesis 4/819 67/18670 0.3387 0.5721 0.4387 MICAL2/GJA1/HIF1A/TMED2 4 BP GO:0046365 monosaccharide catabolic process 4/819 67/18670 0.3387 0.5721 0.4387 SORD/BAD/PGM1/TPI1 4 BP GO:0048662 negative regulation of smooth muscle cell proliferation 4/819 67/18670 0.3387 0.5721 0.4387 IL12A/TPM1/KLF4/CNN1 4 BP GO:0048747 muscle fiber development 4/819 67/18670 0.3387 0.5721 0.4387 COMP/BMP4/LOX/BCL2 4 BP GO:0060038 cardiac muscle cell proliferation 4/819 67/18670 0.3387 0.5721 0.4387 GJA1/TGFBR1/FOXC1/TGFB2 4 BP GO:0061371 determination of heart left/right asymmetry 4/819 67/18670 0.3387 0.5721 0.4387 MICAL2/GJA1/HIF1A/TMED2 4 BP GO:0042551 neuron maturation 3/819 47/18670 0.3404 0.5731 0.4395 MYOC/MTOR/BCL2 3 BP GO:0043303 mast cell degranulation 3/819 47/18670 0.3404 0.5731 0.4395 S100A13/IL13RA2/IL4R 3 BP GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 3/819 47/18670 0.3404 0.5731 0.4395 SOCS5/IL4R/HLX 3 BP GO:0045023 G0 to G1 transition 3/819 47/18670 0.3404 0.5731 0.4395 YAF2/RRM2/RYBP 3 BP GO:0045058 T cell selection 3/819 47/18670 0.3404 0.5731 0.4395 STAT3/MTOR/BCL2 3 BP GO:0046638 positive regulation of alpha-beta T cell differentiation 3/819 47/18670 0.3404 0.5731 0.4395 SOCS5/IL4R/HLX 3 BP GO:0047496 vesicle transport along microtubule 3/819 47/18670 0.3404 0.5731 0.4395 TRAK2/CLN3/DYNC1I1 3 BP GO:0048806 genitalia development 3/819 47/18670 0.3404 0.5731 0.4395 ASB1/ROR2/PTPN11 3 BP GO:0060986 endocrine hormone secretion 3/819 47/18670 0.3404 0.5731 0.4395 INHBB/PTPN11/TMF1 3 BP GO:1903580 positive regulation of ATP metabolic process 3/819 47/18670 0.3404 0.5731 0.4395 NUPR1/HIF1A/STAT3 3 BP GO:0032088 negative regulation of NF-kappaB transcription factor activity 5/819 88/18670 0.3432 0.577 0.4425 CYP1B1/ARRB2/KLF4/CAT/CDKN2A 5 BP GO:0043044 ATP-dependent chromatin remodeling 5/819 88/18670 0.3432 0.577 0.4425 SMARCA1/ITGB3BP/POLE3/ANP32E/SMARCE1 5 BP GO:0098773 skin epidermis development 5/819 88/18670 0.3432 0.577 0.4425 MYO5A/FZD6/PDGFA/TGFB2/BCL2 5 BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 5/819 88/18670 0.3432 0.577 0.4425 ISG15/ARRB2/MTOR/PER2/SOX4 5 BP GO:0055088 lipid homeostasis 8/819 151/18670 0.3439 0.5781 0.4434 GRAMD1B/ABCG1/ABHD5/NR1H2/NR1H3/CD24/CAV3/PNPLA2 8 BP GO:0030522 intracellular receptor signaling pathway 14/819 280/18670 0.3462 0.5788 0.4439 VDR/ARNTL/PRCP/NR1H2/NR1H3/SNAI2/FKBP4/WBP2/STAT3/ARRB2/JAK2/IRF7/STRN3/PHB 14 BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 12/819 237/18670 0.347 0.5788 0.4439 SLC20A1/ANGPT1/GJA1/PRKD1/TGM2/TRIM25/S100A13/USP10/PRKCB/UBE2I/LPAR1/HTR2B 12 BP GO:0006625 protein targeting to peroxisome 4/819 68/18670 0.3488 0.5788 0.4439 HMGCL/MPV17/PEX7/CAT 4 BP GO:0033047 regulation of mitotic sister chromatid segregation 4/819 68/18670 0.3488 0.5788 0.4439 ESPL1/SMC5/ANAPC15/IK 4 BP GO:0046323 glucose import 4/819 68/18670 0.3488 0.5788 0.4439 ENPP1/PIK3R1/GRB10/PTPN11 4 BP GO:0051965 positive regulation of synapse assembly 4/819 68/18670 0.3488 0.5788 0.4439 TPBG/EPHB2/IL1RAP/NTRK2 4 BP GO:0071242 cellular response to ammonium ion 4/819 68/18670 0.3488 0.5788 0.4439 MAPK3/ADCY8/DIAPH1/PLCB1 4 BP GO:0072662 protein localization to peroxisome 4/819 68/18670 0.3488 0.5788 0.4439 HMGCL/MPV17/PEX7/CAT 4 BP GO:0072663 establishment of protein localization to peroxisome 4/819 68/18670 0.3488 0.5788 0.4439 HMGCL/MPV17/PEX7/CAT 4 BP GO:0006972 hyperosmotic response 2/819 28/18670 0.3494 0.5788 0.4439 XRCC6/PKN1 2 BP GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway 2/819 28/18670 0.3494 0.5788 0.4439 GAP43/HTR2B 2 BP GO:0008045 motor neuron axon guidance 2/819 28/18670 0.3494 0.5788 0.4439 NRP1/CHN1 2 BP GO:0009065 glutamine family amino acid catabolic process 2/819 28/18670 0.3494 0.5788 0.4439 DDAH2/FAH 2 BP GO:0032196 transposition 2/819 28/18670 0.3494 0.5788 0.4439 APOBEC3B/APOBEC3C 2 BP GO:0033688 regulation of osteoblast proliferation 2/819 28/18670 0.3494 0.5788 0.4439 GREM1/BCL2 2 BP GO:0034368 protein-lipid complex remodeling 2/819 28/18670 0.3494 0.5788 0.4439 ABCG1/PLTP 2 BP GO:0034369 plasma lipoprotein particle remodeling 2/819 28/18670 0.3494 0.5788 0.4439 ABCG1/PLTP 2 BP GO:0034698 response to gonadotropin 2/819 28/18670 0.3494 0.5788 0.4439 ITGA3/GCLM 2 BP GO:0042634 regulation of hair cycle 2/819 28/18670 0.3494 0.5788 0.4439 ARNTL/TGFB2 2 BP GO:0042730 fibrinolysis 2/819 28/18670 0.3494 0.5788 0.4439 THBS1/FAP 2 BP GO:0045761 regulation of adenylate cyclase activity 2/819 28/18670 0.3494 0.5788 0.4439 PALM/CACNA1C 2 BP GO:0048520 positive regulation of behavior 2/819 28/18670 0.3494 0.5788 0.4439 GJA1/MTOR 2 BP GO:0048679 regulation of axon regeneration 2/819 28/18670 0.3494 0.5788 0.4439 GRN/KLF4 2 BP GO:0050686 negative regulation of mRNA processing 2/819 28/18670 0.3494 0.5788 0.4439 SAP18/SRSF7 2 BP GO:0051647 nucleus localization 2/819 28/18670 0.3494 0.5788 0.4439 CAV3/BIN1 2 BP GO:0051984 positive regulation of chromosome segregation 2/819 28/18670 0.3494 0.5788 0.4439 ESPL1/SMC5 2 BP GO:0070198 protein localization to chromosome, telomeric region 2/819 28/18670 0.3494 0.5788 0.4439 TERF2/CCT7 2 BP GO:0070861 regulation of protein exit from endoplasmic reticulum 2/819 28/18670 0.3494 0.5788 0.4439 TM9SF4/UBE2J1 2 BP GO:0086013 membrane repolarization during cardiac muscle cell action potential 2/819 28/18670 0.3494 0.5788 0.4439 KCND3/ATP1B1 2 BP GO:2000108 positive regulation of leukocyte apoptotic process 2/819 28/18670 0.3494 0.5788 0.4439 PIK3CB/CDKN2A 2 BP GO:0032410 negative regulation of transporter activity 5/819 89/18670 0.3519 0.5788 0.4439 GSTO1/CLIC2/EPHB2/GNB5/CAV3 5 BP GO:1902807 negative regulation of cell cycle G1/S phase transition 7/819 131/18670 0.352 0.5788 0.4439 NACC2/PRMT1/KLF4/BCL2/SOX4/CTDSP2/CDKN2A 7 BP GO:0002279 mast cell activation involved in immune response 3/819 48/18670 0.3525 0.5788 0.4439 S100A13/IL13RA2/IL4R 3 BP GO:0002711 positive regulation of T cell mediated immunity 3/819 48/18670 0.3525 0.5788 0.4439 IL18R1/IL12A/RSAD2 3 BP GO:0006111 regulation of gluconeogenesis 3/819 48/18670 0.3525 0.5788 0.4439 KAT2B/FBP1/PDK2 3 BP GO:0045933 positive regulation of muscle contraction 3/819 48/18670 0.3525 0.5788 0.4439 GSTO1/RGS2/ITGA2 3 BP GO:0051653 spindle localization 3/819 48/18670 0.3525 0.5788 0.4439 ESPL1/NSFL1C/MYH9 3 BP GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 3/819 48/18670 0.3525 0.5788 0.4439 CLEC16A/MAP1A/RYBP 3 BP GO:0098739 import across plasma membrane 6/819 110/18670 0.3526 0.5788 0.4439 FOLR2/SLC1A5/ATP1B1/CNGA3/RGS2/PER2 6 BP GO:2001252 positive regulation of chromosome organization 9/819 174/18670 0.3549 0.5788 0.4439 MAPK3/MAP3K4/ESPL1/PRKD1/SNAI2/WBP2/SMC5/NEK7/CCT7 9 BP GO:0050729 positive regulation of inflammatory response 8/819 153/18670 0.3572 0.5788 0.4439 CTSC/GRN/NUPR1/TGM2/OSMR/JAK2/IL6ST/ITGA2 8 BP GO:0043574 peroxisomal transport 4/819 69/18670 0.3589 0.5788 0.4439 HMGCL/MPV17/PEX7/CAT 4 BP GO:0050771 negative regulation of axonogenesis 4/819 69/18670 0.3589 0.5788 0.4439 TRAK2/EPHB2/NRP1/THY1 4 BP GO:0030518 intracellular steroid hormone receptor signaling pathway 7/819 132/18670 0.3591 0.5788 0.4439 ARNTL/FKBP4/WBP2/ARRB2/JAK2/STRN3/PHB 7 BP GO:0000012 single strand break repair 1/819 10/18670 0.3615 0.5788 0.4439 TERF2 1 BP GO:0000338 protein deneddylation 1/819 10/18670 0.3615 0.5788 0.4439 COPS8 1 BP GO:0002713 negative regulation of B cell mediated immunity 1/819 10/18670 0.3615 0.5788 0.4439 THOC1 1 BP GO:0002890 negative regulation of immunoglobulin mediated immune response 1/819 10/18670 0.3615 0.5788 0.4439 THOC1 1 BP GO:0003183 mitral valve morphogenesis 1/819 10/18670 0.3615 0.5788 0.4439 SOX4 1 BP GO:0003211 cardiac ventricle formation 1/819 10/18670 0.3615 0.5788 0.4439 SOX4 1 BP GO:0003376 sphingosine-1-phosphate receptor signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 EZR 1 BP GO:0006002 fructose 6-phosphate metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 FBP1 1 BP GO:0006188 IMP biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 GART 1 BP GO:0006228 UTP biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 NME3 1 BP GO:0006285 base-excision repair, AP site formation 1/819 10/18670 0.3615 0.5788 0.4439 MBD4 1 BP GO:0006547 histidine metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 MTHFD1 1 BP GO:0006560 proline metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 PYCR1 1 BP GO:0006751 glutathione catabolic process 1/819 10/18670 0.3615 0.5788 0.4439 GGT5 1 BP GO:0007028 cytoplasm organization 1/819 10/18670 0.3615 0.5788 0.4439 ETV6 1 BP GO:0007135 meiosis II 1/819 10/18670 0.3615 0.5788 0.4439 PPP2R1A 1 BP GO:0009157 deoxyribonucleoside monophosphate biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 TK2 1 BP GO:0010749 regulation of nitric oxide mediated signal transduction 1/819 10/18670 0.3615 0.5788 0.4439 THBS1 1 BP GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 1/819 10/18670 0.3615 0.5788 0.4439 NCK1 1 BP GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation 1/819 10/18670 0.3615 0.5788 0.4439 SGCA 1 BP GO:0014894 response to denervation involved in regulation of muscle adaptation 1/819 10/18670 0.3615 0.5788 0.4439 SGCA 1 BP GO:0015809 arginine transport 1/819 10/18670 0.3615 0.5788 0.4439 CLN3 1 BP GO:0015937 coenzyme A biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 COASY 1 BP GO:0016102 diterpenoid biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 ALDH1A3 1 BP GO:0018065 protein-cofactor linkage 1/819 10/18670 0.3615 0.5788 0.4439 NDUFAB1 1 BP GO:0018342 protein prenylation 1/819 10/18670 0.3615 0.5788 0.4439 RABGGTA 1 BP GO:0019062 virion attachment to host cell 1/819 10/18670 0.3615 0.5788 0.4439 GAS6 1 BP GO:0021877 forebrain neuron fate commitment 1/819 10/18670 0.3615 0.5788 0.4439 SATB2 1 BP GO:0030388 fructose 1,6-bisphosphate metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 FBP1 1 BP GO:0031848 protection from non-homologous end joining at telomere 1/819 10/18670 0.3615 0.5788 0.4439 TERF2 1 BP GO:0032025 response to cobalt ion 1/819 10/18670 0.3615 0.5788 0.4439 CASP9 1 BP GO:0032275 luteinizing hormone secretion 1/819 10/18670 0.3615 0.5788 0.4439 TMF1 1 BP GO:0032463 negative regulation of protein homooligomerization 1/819 10/18670 0.3615 0.5788 0.4439 CRYAB 1 BP GO:0032464 positive regulation of protein homooligomerization 1/819 10/18670 0.3615 0.5788 0.4439 HRK 1 BP GO:0033131 regulation of glucokinase activity 1/819 10/18670 0.3615 0.5788 0.4439 BAD 1 BP GO:0033210 leptin-mediated signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 STAT3 1 BP GO:0033483 gas homeostasis 1/819 10/18670 0.3615 0.5788 0.4439 HIF1A 1 BP GO:0034447 very-low-density lipoprotein particle clearance 1/819 10/18670 0.3615 0.5788 0.4439 VLDLR 1 BP GO:0035090 maintenance of apical/basal cell polarity 1/819 10/18670 0.3615 0.5788 0.4439 WNT11 1 BP GO:0035247 peptidyl-arginine omega-N-methylation 1/819 10/18670 0.3615 0.5788 0.4439 PRMT1 1 BP GO:0035646 endosome to melanosome transport 1/819 10/18670 0.3615 0.5788 0.4439 RAB32 1 BP GO:0039530 MDA-5 signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 IRF7 1 BP GO:0042428 serotonin metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 GRIN2A 1 BP GO:0042756 drinking behavior 1/819 10/18670 0.3615 0.5788 0.4439 MMP17 1 BP GO:0042891 antibiotic transport 1/819 10/18670 0.3615 0.5788 0.4439 MFSD10 1 BP GO:0043485 endosome to pigment granule transport 1/819 10/18670 0.3615 0.5788 0.4439 RAB32 1 BP GO:0044351 macropinocytosis 1/819 10/18670 0.3615 0.5788 0.4439 MAPKAPK3 1 BP GO:0044359 modulation of molecular function in other organism 1/819 10/18670 0.3615 0.5788 0.4439 PTX3 1 BP GO:0044557 relaxation of smooth muscle 1/819 10/18670 0.3615 0.5788 0.4439 RGS2 1 BP GO:0044803 multi-organism membrane organization 1/819 10/18670 0.3615 0.5788 0.4439 GAS6 1 BP GO:0045199 maintenance of epithelial cell apical/basal polarity 1/819 10/18670 0.3615 0.5788 0.4439 WNT11 1 BP GO:0045348 positive regulation of MHC class II biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 JAK2 1 BP GO:0045713 low-density lipoprotein particle receptor biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 ITGB3 1 BP GO:0045876 positive regulation of sister chromatid cohesion 1/819 10/18670 0.3615 0.5788 0.4439 SMC5 1 BP GO:0045945 positive regulation of transcription by RNA polymerase III 1/819 10/18670 0.3615 0.5788 0.4439 MTOR 1 BP GO:0045988 negative regulation of striated muscle contraction 1/819 10/18670 0.3615 0.5788 0.4439 BIN1 1 BP GO:0046485 ether lipid metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 PEX7 1 BP GO:0046532 regulation of photoreceptor cell differentiation 1/819 10/18670 0.3615 0.5788 0.4439 TUG1 1 BP GO:0046642 negative regulation of alpha-beta T cell proliferation 1/819 10/18670 0.3615 0.5788 0.4439 TNFRSF14 1 BP GO:0046710 GDP metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 GUK1 1 BP GO:0048149 behavioral response to ethanol 1/819 10/18670 0.3615 0.5788 0.4439 EPS8 1 BP GO:0048262 determination of dorsal/ventral asymmetry 1/819 10/18670 0.3615 0.5788 0.4439 GREM1 1 BP GO:0048703 embryonic viscerocranium morphogenesis 1/819 10/18670 0.3615 0.5788 0.4439 MTHFD1 1 BP GO:0048757 pigment granule maturation 1/819 10/18670 0.3615 0.5788 0.4439 RAB32 1 BP GO:0050861 positive regulation of B cell receptor signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 PRKCB 1 BP GO:0051133 regulation of NK T cell activation 1/819 10/18670 0.3615 0.5788 0.4439 IL12A 1 BP GO:0051231 spindle elongation 1/819 10/18670 0.3615 0.5788 0.4439 PPP2R1A 1 BP GO:0051409 response to nitrosative stress 1/819 10/18670 0.3615 0.5788 0.4439 GCLM 1 BP GO:0051901 positive regulation of mitochondrial depolarization 1/819 10/18670 0.3615 0.5788 0.4439 MYOC 1 BP GO:0051918 negative regulation of fibrinolysis 1/819 10/18670 0.3615 0.5788 0.4439 THBS1 1 BP GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction 1/819 10/18670 0.3615 0.5788 0.4439 PTX3 1 BP GO:0052646 alditol phosphate metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 GPD1L 1 BP GO:0060281 regulation of oocyte development 1/819 10/18670 0.3615 0.5788 0.4439 PPP2R1A 1 BP GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry 1/819 10/18670 0.3615 0.5788 0.4439 RFX3 1 BP GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization 1/819 10/18670 0.3615 0.5788 0.4439 GJA1 1 BP GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress 1/819 10/18670 0.3615 0.5788 0.4439 HSF4 1 BP GO:0061983 meiosis II cell cycle process 1/819 10/18670 0.3615 0.5788 0.4439 PPP2R1A 1 BP GO:0070099 regulation of chemokine-mediated signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 HIF1A 1 BP GO:0070170 regulation of tooth mineralization 1/819 10/18670 0.3615 0.5788 0.4439 TFAP2A 1 BP GO:0070341 fat cell proliferation 1/819 10/18670 0.3615 0.5788 0.4439 PER2 1 BP GO:0070344 regulation of fat cell proliferation 1/819 10/18670 0.3615 0.5788 0.4439 PER2 1 BP GO:0070862 negative regulation of protein exit from endoplasmic reticulum 1/819 10/18670 0.3615 0.5788 0.4439 UBE2J1 1 BP GO:0070942 neutrophil mediated cytotoxicity 1/819 10/18670 0.3615 0.5788 0.4439 DNASE1L3 1 BP GO:0071104 response to interleukin-9 1/819 10/18670 0.3615 0.5788 0.4439 STAT3 1 BP GO:0071281 cellular response to iron ion 1/819 10/18670 0.3615 0.5788 0.4439 TFAP2A 1 BP GO:0071670 smooth muscle cell chemotaxis 1/819 10/18670 0.3615 0.5788 0.4439 LPAR1 1 BP GO:0072124 regulation of glomerular mesangial cell proliferation 1/819 10/18670 0.3615 0.5788 0.4439 BMP4 1 BP GO:0086070 SA node cell to atrial cardiac muscle cell communication 1/819 10/18670 0.3615 0.5788 0.4439 GJC1 1 BP GO:0090037 positive regulation of protein kinase C signaling 1/819 10/18670 0.3615 0.5788 0.4439 WNT11 1 BP GO:0090205 positive regulation of cholesterol metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 ABCG1 1 BP GO:0097050 type B pancreatic cell apoptotic process 1/819 10/18670 0.3615 0.5788 0.4439 TCF7L2 1 BP GO:0097278 complement-dependent cytotoxicity 1/819 10/18670 0.3615 0.5788 0.4439 CD55 1 BP GO:0097354 prenylation 1/819 10/18670 0.3615 0.5788 0.4439 RABGGTA 1 BP GO:0098917 retrograde trans-synaptic signaling 1/819 10/18670 0.3615 0.5788 0.4439 PLCB1 1 BP GO:0106049 regulation of cellular response to osmotic stress 1/819 10/18670 0.3615 0.5788 0.4439 BAD 1 BP GO:1900122 positive regulation of receptor binding 1/819 10/18670 0.3615 0.5788 0.4439 NRP1 1 BP GO:1901725 regulation of histone deacetylase activity 1/819 10/18670 0.3615 0.5788 0.4439 PRKD1 1 BP GO:1901748 leukotriene D4 metabolic process 1/819 10/18670 0.3615 0.5788 0.4439 GGT5 1 BP GO:1901750 leukotriene D4 biosynthetic process 1/819 10/18670 0.3615 0.5788 0.4439 GGT5 1 BP GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/819 10/18670 0.3615 0.5788 0.4439 MTOR 1 BP GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 1/819 10/18670 0.3615 0.5788 0.4439 ESPL1 1 BP GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1/819 10/18670 0.3615 0.5788 0.4439 NCK1 1 BP GO:1903405 protein localization to nuclear body 1/819 10/18670 0.3615 0.5788 0.4439 CCT7 1 BP GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 1/819 10/18670 0.3615 0.5788 0.4439 BMP4 1 BP GO:1903862 positive regulation of oxidative phosphorylation 1/819 10/18670 0.3615 0.5788 0.4439 NUPR1 1 BP GO:1904526 regulation of microtubule binding 1/819 10/18670 0.3615 0.5788 0.4439 MAPRE3 1 BP GO:1904779 regulation of protein localization to centrosome 1/819 10/18670 0.3615 0.5788 0.4439 NSFL1C 1 BP GO:1904851 positive regulation of establishment of protein localization to telomere 1/819 10/18670 0.3615 0.5788 0.4439 CCT7 1 BP GO:1904867 protein localization to Cajal body 1/819 10/18670 0.3615 0.5788 0.4439 CCT7 1 BP GO:1904896 ESCRT complex disassembly 1/819 10/18670 0.3615 0.5788 0.4439 CHMP2A 1 BP GO:1904903 ESCRT III complex disassembly 1/819 10/18670 0.3615 0.5788 0.4439 CHMP2A 1 BP GO:1905879 regulation of oogenesis 1/819 10/18670 0.3615 0.5788 0.4439 PPP2R1A 1 BP GO:1990535 neuron projection maintenance 1/819 10/18670 0.3615 0.5788 0.4439 MAP1A 1 BP GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 1/819 10/18670 0.3615 0.5788 0.4439 ADAM19 1 BP GO:2000253 positive regulation of feeding behavior 1/819 10/18670 0.3615 0.5788 0.4439 MTOR 1 BP GO:2000849 regulation of glucocorticoid secretion 1/819 10/18670 0.3615 0.5788 0.4439 PTPN11 1 BP GO:2001054 negative regulation of mesenchymal cell apoptotic process 1/819 10/18670 0.3615 0.5788 0.4439 HIF1A 1 BP GO:2001214 positive regulation of vasculogenesis 1/819 10/18670 0.3615 0.5788 0.4439 RAMP2 1 BP GO:0010466 negative regulation of peptidase activity 13/819 262/18670 0.3645 0.5808 0.4454 RENBP/CRYAB/SIAH2/THBS1/SERPINH1/LAMTOR5/COL6A3/COL7A1/SERPINB6/ARRB2/KLF4/GAS6/BIN1 13 BP GO:0001913 T cell mediated cytotoxicity 3/819 49/18670 0.3646 0.5808 0.4454 CTSC/MICB/IL12A 3 BP GO:0002448 mast cell mediated immunity 3/819 49/18670 0.3646 0.5808 0.4454 S100A13/IL13RA2/IL4R 3 BP GO:0008347 glial cell migration 3/819 49/18670 0.3646 0.5808 0.4454 IDH2/LAMB1/TGFB2 3 BP GO:0051205 protein insertion into membrane 3/819 49/18670 0.3646 0.5808 0.4454 NMT1/BAD/BCL2 3 BP GO:0000303 response to superoxide 2/819 29/18670 0.3655 0.5808 0.4454 SOD3/FBLN5 2 BP GO:0005979 regulation of glycogen biosynthetic process 2/819 29/18670 0.3655 0.5808 0.4454 ENPP1/MTOR 2 BP GO:0006294 nucleotide-excision repair, preincision complex assembly 2/819 29/18670 0.3655 0.5808 0.4454 RPA3/XPC 2 BP GO:0010390 histone monoubiquitination 2/819 29/18670 0.3655 0.5808 0.4454 UBE2E1/RYBP 2 BP GO:0010962 regulation of glucan biosynthetic process 2/819 29/18670 0.3655 0.5808 0.4454 ENPP1/MTOR 2 BP GO:0014044 Schwann cell development 2/819 29/18670 0.3655 0.5808 0.4454 MYOC/NTRK2 2 BP GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 2/819 29/18670 0.3655 0.5808 0.4454 THBS1/CREBBP 2 BP GO:0030970 retrograde protein transport, ER to cytosol 2/819 29/18670 0.3655 0.5808 0.4454 SEL1L/UBE2J1 2 BP GO:0032232 negative regulation of actin filament bundle assembly 2/819 29/18670 0.3655 0.5808 0.4454 MYOC/MET 2 BP GO:0034367 protein-containing complex remodeling 2/819 29/18670 0.3655 0.5808 0.4454 ABCG1/PLTP 2 BP GO:0035025 positive regulation of Rho protein signal transduction 2/819 29/18670 0.3655 0.5808 0.4454 COL3A1/LPAR1 2 BP GO:0060142 regulation of syncytium formation by plasma membrane fusion 2/819 29/18670 0.3655 0.5808 0.4454 IL4R/CAMK1 2 BP GO:0060765 regulation of androgen receptor signaling pathway 2/819 29/18670 0.3655 0.5808 0.4454 ARRB2/PHB 2 BP GO:0070229 negative regulation of lymphocyte apoptotic process 2/819 29/18670 0.3655 0.5808 0.4454 BMP4/HIF1A 2 BP GO:0070723 response to cholesterol 2/819 29/18670 0.3655 0.5808 0.4454 GRAMD1B/TGFBR1 2 BP GO:1900181 negative regulation of protein localization to nucleus 2/819 29/18670 0.3655 0.5808 0.4454 ANGPT1/MDFIC 2 BP GO:1903513 endoplasmic reticulum to cytosol transport 2/819 29/18670 0.3655 0.5808 0.4454 SEL1L/UBE2J1 2 BP GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 2/819 29/18670 0.3655 0.5808 0.4454 THBS1/CREBBP 2 BP GO:1990126 retrograde transport, endosome to plasma membrane 2/819 29/18670 0.3655 0.5808 0.4454 SNX27/RAB8A 2 BP GO:2000765 regulation of cytoplasmic translation 2/819 29/18670 0.3655 0.5808 0.4454 MTOR/NCK1 2 BP GO:0009581 detection of external stimulus 7/819 133/18670 0.3664 0.5818 0.4462 COL11A1/CXCL12/CDS1/NMT1/CAV3/ARRB2/ITGA2 7 BP GO:0042770 signal transduction in response to DNA damage 7/819 133/18670 0.3664 0.5818 0.4462 SNAI2/PRMT1/PTTG1IP/USP10/CASP9/FOXO3/SOX4 7 BP GO:0016485 protein processing 16/819 328/18670 0.3675 0.5835 0.4475 CD55/PCSK5/THBS1/CLN3/COMP/SPCS2/C1S/MYH9/PIK3C3/GSN/C1R/SPON1/BAD/PHB/CPM/GRIN2A 16 BP GO:0008645 hexose transmembrane transport 6/819 112/18670 0.3684 0.5845 0.4483 ENPP1/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11 6 BP GO:0032411 positive regulation of transporter activity 6/819 112/18670 0.3684 0.5845 0.4483 GSTO1/EPHB2/HSPA2/ATP1B1/STAC/TRPC6 6 BP GO:0001756 somitogenesis 4/819 70/18670 0.3689 0.5851 0.4487 FOXC1/ROR2/KDM6A/TMED2 4 BP GO:0034121 regulation of toll-like receptor signaling pathway 4/819 70/18670 0.3689 0.5851 0.4487 NR1H3/ARRB2/RSAD2/IRF7 4 BP GO:1903707 negative regulation of hemopoiesis 8/819 155/18670 0.3706 0.5875 0.4506 BMP4/PIK3R1/CIB1/PRMT1/ZFP36/SOCS5/IL4R/HLX 8 BP GO:0007416 synapse assembly 9/819 177/18670 0.3737 0.5922 0.4542 TPBG/EPHB2/IL1RAP/GAP43/NTRK2/PLXND1/GPC4/RAB29/FZD1 9 BP GO:0140014 mitotic nuclear division 13/819 264/18670 0.3747 0.5936 0.4552 ESPL1/PIN1/BMP4/NSFL1C/POGZ/SMC5/RRS1/EPS8/CHMP2A/PPP2R1A/ANAPC15/KIF2C/IK 13 BP GO:0048640 negative regulation of developmental growth 6/819 113/18670 0.3762 0.5936 0.4552 STC2/BMP4/GJA1/NRP1/CAV3/RGS2 6 BP GO:0009409 response to cold 3/819 50/18670 0.3767 0.5936 0.4552 HSPA2/UCP2/GMPR 3 BP GO:0009948 anterior/posterior axis specification 3/819 50/18670 0.3767 0.5936 0.4552 BMP4/KDM6A/TMED2 3 BP GO:0014009 glial cell proliferation 3/819 50/18670 0.3767 0.5936 0.4552 IDH2/MTOR/SOX4 3 BP GO:0043489 RNA stabilization 3/819 50/18670 0.3767 0.5936 0.4552 HNRNPA0/ZFP36/MTOR 3 BP GO:0097035 regulation of membrane lipid distribution 3/819 50/18670 0.3767 0.5936 0.4552 ATP8A1/ATP11B/KCNN4 3 BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 11/819 221/18670 0.3777 0.5936 0.4552 FPR1/PRKCA/ADCY8/RAMP2/ADCY7/CCR3/PALM/RGS2/GABBR1/LPAR1/EDNRA 11 BP GO:0019724 B cell mediated immunity 11/819 221/18670 0.3777 0.5936 0.4552 CD55/THOC1/CD70/C1S/IL13RA2/C1R/IL4R/IGLL1/HLA-DQB1/IRF7/TCIRG1 11 BP GO:0050795 regulation of behavior 4/819 71/18670 0.379 0.5936 0.4552 GJA1/STAT3/MTOR/HTR2B 4 BP GO:0051057 positive regulation of small GTPase mediated signal transduction 4/819 71/18670 0.379 0.5936 0.4552 COL3A1/RAPGEF1/JAK2/LPAR1 4 BP GO:0010950 positive regulation of endopeptidase activity 9/819 178/18670 0.3799 0.5936 0.4552 HIP1R/MAP3K5/GSN/STAT3/JAK2/GRIN2B/BAD/CASP9/GRIN2A 9 BP GO:0001889 liver development 7/819 135/18670 0.3808 0.5936 0.4552 ACO2/HMGCL/PHF2/QDPR/MET/ITGA2/HLX 7 BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 7/819 135/18670 0.3808 0.5936 0.4552 PIN1/ANGPT1/HSPA5/ARRB2/PTTG1IP/UBE2I/RCHY1 7 BP GO:1903825 organic acid transmembrane transport 7/819 135/18670 0.3808 0.5936 0.4552 SLC35D2/SLC7A8/THBS1/FOLR2/SLC1A5/RGS2/PER2 7 BP GO:1905039 carboxylic acid transmembrane transport 7/819 135/18670 0.3808 0.5936 0.4552 SLC35D2/SLC7A8/THBS1/FOLR2/SLC1A5/RGS2/PER2 7 BP GO:0006401 RNA catabolic process 19/819 397/18670 0.3813 0.5936 0.4552 PSMD8/PSMB7/PRKCA/EXOSC7/OAS2/PSMD1/HNRNPA0/SAMD4A/TNRC6B/PSMB6/RNH1/ZFP36/EXOSC2/MTOR/PPP2R1A/PSMD3/LSM4/PSMD2/PSMB8 19 BP GO:0000038 very long-chain fatty acid metabolic process 2/819 30/18670 0.3814 0.5936 0.4552 ELOVL2/TECR 2 BP GO:0000305 response to oxygen radical 2/819 30/18670 0.3814 0.5936 0.4552 SOD3/FBLN5 2 BP GO:0003209 cardiac atrium morphogenesis 2/819 30/18670 0.3814 0.5936 0.4552 TGFB2/SOX4 2 BP GO:0006362 transcription elongation from RNA polymerase I promoter 2/819 30/18670 0.3814 0.5936 0.4552 POLR2L/POLR2E 2 BP GO:0032743 positive regulation of interleukin-2 production 2/819 30/18670 0.3814 0.5936 0.4552 PDE4B/SPTBN1 2 BP GO:0034472 snRNA 3'-end processing 2/819 30/18670 0.3814 0.5936 0.4552 EXOSC7/EXOSC2 2 BP GO:0045954 positive regulation of natural killer cell mediated cytotoxicity 2/819 30/18670 0.3814 0.5936 0.4552 MICB/IL12A 2 BP GO:0046640 regulation of alpha-beta T cell proliferation 2/819 30/18670 0.3814 0.5936 0.4552 CD55/TNFRSF14 2 BP GO:0048147 negative regulation of fibroblast proliferation 2/819 30/18670 0.3814 0.5936 0.4552 NUPR1/PAWR 2 BP GO:0048265 response to pain 2/819 30/18670 0.3814 0.5936 0.4552 THBS4/THBS1 2 BP GO:0050690 regulation of defense response to virus by virus 2/819 30/18670 0.3814 0.5936 0.4552 ATP6V1H/AP2B1 2 BP GO:0061082 myeloid leukocyte cytokine production 2/819 30/18670 0.3814 0.5936 0.4552 TGFB2/GAS6 2 BP GO:0090022 regulation of neutrophil chemotaxis 2/819 30/18670 0.3814 0.5936 0.4552 THBS4/BST1 2 BP GO:0090200 positive regulation of release of cytochrome c from mitochondria 2/819 30/18670 0.3814 0.5936 0.4552 HRK/BAD 2 BP GO:1904893 negative regulation of STAT cascade 2/819 30/18670 0.3814 0.5936 0.4552 SOCS3/PPP2R1A 2 BP GO:1905476 negative regulation of protein localization to membrane 2/819 30/18670 0.3814 0.5936 0.4552 BCL2L1/ITGB1BP1 2 BP GO:0019827 stem cell population maintenance 8/819 157/18670 0.384 0.5936 0.4552 POLR2L/POLR2E/FZD7/LOXL2/STAT3/KLF4/FOXO3/SOX4 8 BP GO:0015749 monosaccharide transmembrane transport 6/819 114/18670 0.3841 0.5936 0.4552 ENPP1/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11 6 BP GO:0042752 regulation of circadian rhythm 6/819 114/18670 0.3841 0.5936 0.4552 ARNTL/SIAH2/MAGED1/NR1H3/MTOR/PER2 6 BP GO:0009582 detection of abiotic stimulus 7/819 136/18670 0.388 0.5936 0.4552 COL11A1/CXCL12/CDS1/NMT1/CAV3/ARRB2/ITGA2 7 BP GO:0019369 arachidonic acid metabolic process 3/819 51/18670 0.3887 0.5936 0.4552 MAPK3/CYP1B1/PLA2G4C 3 BP GO:0030071 regulation of mitotic metaphase/anaphase transition 3/819 51/18670 0.3887 0.5936 0.4552 ESPL1/ANAPC15/IK 3 BP GO:0043949 regulation of cAMP-mediated signaling 3/819 51/18670 0.3887 0.5936 0.4552 PRKCA/RGS2/LPAR1 3 BP GO:0045599 negative regulation of fat cell differentiation 3/819 51/18670 0.3887 0.5936 0.4552 ENPP1/ARNTL/WWTR1 3 BP GO:0048146 positive regulation of fibroblast proliferation 3/819 51/18670 0.3887 0.5936 0.4552 PDGFA/DDR2/GAS6 3 BP GO:0097366 response to bronchodilator 3/819 51/18670 0.3887 0.5936 0.4552 RGS2/ASIC1/GRIN2A 3 BP GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 4/819 72/18670 0.389 0.5936 0.4552 CLEC16A/UBE2J1/MAP1A/RYBP 4 BP GO:0000185 activation of MAPKKK activity 1/819 11/18670 0.3896 0.5936 0.4552 MAP4K2 1 BP GO:0000478 endonucleolytic cleavage involved in rRNA processing 1/819 11/18670 0.3896 0.5936 0.4552 RRS1 1 BP GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1/819 11/18670 0.3896 0.5936 0.4552 RRS1 1 BP GO:0001574 ganglioside biosynthetic process 1/819 11/18670 0.3896 0.5936 0.4552 ST3GAL5 1 BP GO:0001731 formation of translation preinitiation complex 1/819 11/18670 0.3896 0.5936 0.4552 EIF2S2 1 BP GO:0002328 pro-B cell differentiation 1/819 11/18670 0.3896 0.5936 0.4552 SOX4 1 BP GO:0002604 regulation of dendritic cell antigen processing and presentation 1/819 11/18670 0.3896 0.5936 0.4552 THBS1 1 BP GO:0002836 positive regulation of response to tumor cell 1/819 11/18670 0.3896 0.5936 0.4552 IL12A 1 BP GO:0002839 positive regulation of immune response to tumor cell 1/819 11/18670 0.3896 0.5936 0.4552 IL12A 1 BP GO:0003174 mitral valve development 1/819 11/18670 0.3896 0.5936 0.4552 SOX4 1 BP GO:0005984 disaccharide metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 FBP1 1 BP GO:0006183 GTP biosynthetic process 1/819 11/18670 0.3896 0.5936 0.4552 NME3 1 BP GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 1/819 11/18670 0.3896 0.5936 0.4552 HSPA5 1 BP GO:0006681 galactosylceramide metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 CLN3 1 BP GO:0008655 pyrimidine-containing compound salvage 1/819 11/18670 0.3896 0.5936 0.4552 TK2 1 BP GO:0009151 purine deoxyribonucleotide metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 GUK1 1 BP GO:0009629 response to gravity 1/819 11/18670 0.3896 0.5936 0.4552 SPARC 1 BP GO:0014870 response to muscle inactivity 1/819 11/18670 0.3896 0.5936 0.4552 SGCA 1 BP GO:0014883 transition between fast and slow fiber 1/819 11/18670 0.3896 0.5936 0.4552 ATP2A2 1 BP GO:0019852 L-ascorbic acid metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 GSTO1 1 BP GO:0031987 locomotion involved in locomotory behavior 1/819 11/18670 0.3896 0.5936 0.4552 MYO5A 1 BP GO:0032276 regulation of gonadotropin secretion 1/819 11/18670 0.3896 0.5936 0.4552 INHBB 1 BP GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway 1/819 11/18670 0.3896 0.5936 0.4552 WBP2 1 BP GO:0033235 positive regulation of protein sumoylation 1/819 11/18670 0.3896 0.5936 0.4552 UBE2I 1 BP GO:0033327 Leydig cell differentiation 1/819 11/18670 0.3896 0.5936 0.4552 TMF1 1 BP GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1/819 11/18670 0.3896 0.5936 0.4552 ETFB 1 BP GO:0033632 regulation of cell-cell adhesion mediated by integrin 1/819 11/18670 0.3896 0.5936 0.4552 PODXL 1 BP GO:0034115 negative regulation of heterotypic cell-cell adhesion 1/819 11/18670 0.3896 0.5936 0.4552 KLF4 1 BP GO:0034776 response to histamine 1/819 11/18670 0.3896 0.5936 0.4552 DIAPH1 1 BP GO:0035246 peptidyl-arginine N-methylation 1/819 11/18670 0.3896 0.5936 0.4552 PRMT1 1 BP GO:0035739 CD4-positive, alpha-beta T cell proliferation 1/819 11/18670 0.3896 0.5936 0.4552 CD55 1 BP GO:0035933 glucocorticoid secretion 1/819 11/18670 0.3896 0.5936 0.4552 PTPN11 1 BP GO:0040015 negative regulation of multicellular organism growth 1/819 11/18670 0.3896 0.5936 0.4552 STC2 1 BP GO:0042271 susceptibility to natural killer cell mediated cytotoxicity 1/819 11/18670 0.3896 0.5936 0.4552 MICB 1 BP GO:0042482 positive regulation of odontogenesis 1/819 11/18670 0.3896 0.5936 0.4552 TFAP2A 1 BP GO:0042670 retinal cone cell differentiation 1/819 11/18670 0.3896 0.5936 0.4552 THY1 1 BP GO:0043097 pyrimidine nucleoside salvage 1/819 11/18670 0.3896 0.5936 0.4552 TK2 1 BP GO:0043129 surfactant homeostasis 1/819 11/18670 0.3896 0.5936 0.4552 EPAS1 1 BP GO:0044793 negative regulation by host of viral process 1/819 11/18670 0.3896 0.5936 0.4552 PTX3 1 BP GO:0045351 type I interferon biosynthetic process 1/819 11/18670 0.3896 0.5936 0.4552 IRF7 1 BP GO:0046051 UTP metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 NME3 1 BP GO:0046185 aldehyde catabolic process 1/819 11/18670 0.3896 0.5936 0.4552 HAGH 1 BP GO:0046501 protoporphyrinogen IX metabolic process 1/819 11/18670 0.3896 0.5936 0.4552 UROS 1 BP GO:0046512 sphingosine biosynthetic process 1/819 11/18670 0.3896 0.5936 0.4552 ASAH1 1 BP GO:0046549 retinal cone cell development 1/819 11/18670 0.3896 0.5936 0.4552 THY1 1 BP GO:0046607 positive regulation of centrosome cycle 1/819 11/18670 0.3896 0.5936 0.4552 NSFL1C 1 BP GO:0046886 positive regulation of hormone biosynthetic process 1/819 11/18670 0.3896 0.5936 0.4552 HIF1A 1 BP GO:0048680 positive regulation of axon regeneration 1/819 11/18670 0.3896 0.5936 0.4552 GRN 1 BP GO:0048742 regulation of skeletal muscle fiber development 1/819 11/18670 0.3896 0.5936 0.4552 BCL2 1 BP GO:0051561 positive regulation of mitochondrial calcium ion concentration 1/819 11/18670 0.3896 0.5936 0.4552 TGM2 1 BP GO:0055091 phospholipid homeostasis 1/819 11/18670 0.3896 0.5936 0.4552 ABCG1 1 BP GO:0060159 regulation of dopamine receptor signaling pathway 1/819 11/18670 0.3896 0.5936 0.4552 PALM 1 BP GO:0060174 limb bud formation 1/819 11/18670 0.3896 0.5936 0.4552 SOX4 1 BP GO:0060272 embryonic skeletal joint morphogenesis 1/819 11/18670 0.3896 0.5936 0.4552 BMP4 1 BP GO:0060379 cardiac muscle cell myoblast differentiation 1/819 11/18670 0.3896 0.5936 0.4552 GREM1 1 BP GO:0060433 bronchus development 1/819 11/18670 0.3896 0.5936 0.4552 BMP4 1 BP GO:0060837 blood vessel endothelial cell differentiation 1/819 11/18670 0.3896 0.5936 0.4552 NRP1 1 BP GO:0061314 Notch signaling involved in heart development 1/819 11/18670 0.3896 0.5936 0.4552 SNAI2 1 BP GO:0070203 regulation of establishment of protein localization to telomere 1/819 11/18670 0.3896 0.5936 0.4552 CCT7 1 BP GO:0070254 mucus secretion 1/819 11/18670 0.3896 0.5936 0.4552 P2RY2 1 BP GO:0070587 regulation of cell-cell adhesion involved in gastrulation 1/819 11/18670 0.3896 0.5936 0.4552 KLF4 1 BP GO:0070673 response to interleukin-18 1/819 11/18670 0.3896 0.5936 0.4552 IL18R1 1 BP GO:0071372 cellular response to follicle-stimulating hormone stimulus 1/819 11/18670 0.3896 0.5936 0.4552 GCLM 1 BP GO:0071803 positive regulation of podosome assembly 1/819 11/18670 0.3896 0.5936 0.4552 FSCN1 1 BP GO:0072110 glomerular mesangial cell proliferation 1/819 11/18670 0.3896 0.5936 0.4552 BMP4 1 BP GO:0072537 fibroblast activation 1/819 11/18670 0.3896 0.5936 0.4552 GCLM 1 BP GO:0072608 interleukin-10 secretion 1/819 11/18670 0.3896 0.5936 0.4552 ISG15 1 BP GO:0086016 AV node cell action potential 1/819 11/18670 0.3896 0.5936 0.4552 CACNA1C 1 BP GO:0086027 AV node cell to bundle of His cell signaling 1/819 11/18670 0.3896 0.5936 0.4552 CACNA1C 1 BP GO:0090084 negative regulation of inclusion body assembly 1/819 11/18670 0.3896 0.5936 0.4552 HSPA2 1 BP GO:0090657 telomeric loop disassembly 1/819 11/18670 0.3896 0.5936 0.4552 TERF2 1 BP GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane 1/819 11/18670 0.3896 0.5936 0.4552 RAB8A 1 BP GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization 1/819 11/18670 0.3896 0.5936 0.4552 ITGB3 1 BP GO:0099151 regulation of postsynaptic density assembly 1/819 11/18670 0.3896 0.5936 0.4552 IL1RAP 1 BP GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 1/819 11/18670 0.3896 0.5936 0.4552 RAB8A 1 BP GO:1901077 regulation of relaxation of muscle 1/819 11/18670 0.3896 0.5936 0.4552 PDE4B 1 BP GO:1901096 regulation of autophagosome maturation 1/819 11/18670 0.3896 0.5936 0.4552 CLEC16A 1 BP GO:1901569 fatty acid derivative catabolic process 1/819 11/18670 0.3896 0.5936 0.4552 OXCT1 1 BP GO:1901894 regulation of calcium-transporting ATPase activity 1/819 11/18670 0.3896 0.5936 0.4552 HSPA2 1 BP GO:1902093 positive regulation of flagellated sperm motility 1/819 11/18670 0.3896 0.5936 0.4552 DEFB1 1 BP GO:1902805 positive regulation of synaptic vesicle transport 1/819 11/18670 0.3896 0.5936 0.4552 UNC13B 1 BP GO:1903011 negative regulation of bone development 1/819 11/18670 0.3896 0.5936 0.4552 GREM1 1 BP GO:1903299 regulation of hexokinase activity 1/819 11/18670 0.3896 0.5936 0.4552 BAD 1 BP GO:1903441 protein localization to ciliary membrane 1/819 11/18670 0.3896 0.5936 0.4552 RAB29 1 BP GO:1903980 positive regulation of microglial cell activation 1/819 11/18670 0.3896 0.5936 0.4552 CTSC 1 BP GO:1904321 response to forskolin 1/819 11/18670 0.3896 0.5936 0.4552 ADCY8 1 BP GO:1904322 cellular response to forskolin 1/819 11/18670 0.3896 0.5936 0.4552 ADCY8 1 BP GO:1905668 positive regulation of protein localization to endosome 1/819 11/18670 0.3896 0.5936 0.4552 EZR 1 BP GO:1905820 positive regulation of chromosome separation 1/819 11/18670 0.3896 0.5936 0.4552 ESPL1 1 BP GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1/819 11/18670 0.3896 0.5936 0.4552 HSPA5 1 BP GO:2000392 regulation of lamellipodium morphogenesis 1/819 11/18670 0.3896 0.5936 0.4552 ENPP2 1 BP GO:2000551 regulation of T-helper 2 cell cytokine production 1/819 11/18670 0.3896 0.5936 0.4552 RSAD2 1 BP GO:2000561 regulation of CD4-positive, alpha-beta T cell proliferation 1/819 11/18670 0.3896 0.5936 0.4552 CD55 1 BP GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1/819 11/18670 0.3896 0.5936 0.4552 PPP2R1A 1 BP GO:0016482 cytosolic transport 8/819 158/18670 0.3907 0.5951 0.4564 MAPK3/PIK3C3/VPS11/GOSR2/RAB29/EZR/PIKFYVE/VAMP3 8 BP GO:0071466 cellular response to xenobiotic stimulus 9/819 180/18670 0.3925 0.5977 0.4584 GSTO1/CYP1B1/ADCY8/FMO1/GHR/FMO3/CYP3A4/FMO2/CASP9 9 BP GO:0016197 endosomal transport 11/819 224/18670 0.3945 0.6001 0.4602 STAM/LYST/GOSR2/CLEC16A/SNX27/RAB8A/CHMP2A/RAB29/TSG101/PIKFYVE/VAMP3 11 BP GO:0031644 regulation of neurological system process 7/819 137/18670 0.3953 0.6001 0.4602 CTSC/NPTX2/FIG4/NPTX1/MTOR/UNC13B/ITGA2 7 BP GO:0072655 establishment of protein localization to mitochondrion 7/819 137/18670 0.3953 0.6001 0.4602 TOMM34/VPS11/HAX1/NMT1/BAD/BCL2/LMAN1 7 BP GO:0002082 regulation of oxidative phosphorylation 2/819 31/18670 0.3971 0.6001 0.4602 NUPR1/COX7A2 2 BP GO:0002675 positive regulation of acute inflammatory response 2/819 31/18670 0.3971 0.6001 0.4602 OSMR/IL6ST 2 BP GO:0002724 regulation of T cell cytokine production 2/819 31/18670 0.3971 0.6001 0.4602 IL18R1/RSAD2 2 BP GO:0002888 positive regulation of myeloid leukocyte mediated immunity 2/819 31/18670 0.3971 0.6001 0.4602 ITGB2/IL4R 2 BP GO:0006363 termination of RNA polymerase I transcription 2/819 31/18670 0.3971 0.6001 0.4602 POLR2L/POLR2E 2 BP GO:0006506 GPI anchor biosynthetic process 2/819 31/18670 0.3971 0.6001 0.4602 PIGH/DPM2 2 BP GO:0009394 2'-deoxyribonucleotide metabolic process 2/819 31/18670 0.3971 0.6001 0.4602 MBD4/GUK1 2 BP GO:0010458 exit from mitosis 2/819 31/18670 0.3971 0.6001 0.4602 EPS8/CHMP2A 2 BP GO:0010543 regulation of platelet activation 2/819 31/18670 0.3971 0.6001 0.4602 PRKCA/PDGFA 2 BP GO:0030149 sphingolipid catabolic process 2/819 31/18670 0.3971 0.6001 0.4602 GM2A/ASAH1 2 BP GO:0033687 osteoblast proliferation 2/819 31/18670 0.3971 0.6001 0.4602 GREM1/BCL2 2 BP GO:0034661 ncRNA catabolic process 2/819 31/18670 0.3971 0.6001 0.4602 EXOSC7/EXOSC2 2 BP GO:0042168 heme metabolic process 2/819 31/18670 0.3971 0.6001 0.4602 BLVRB/UROS 2 BP GO:0043304 regulation of mast cell degranulation 2/819 31/18670 0.3971 0.6001 0.4602 IL13RA2/IL4R 2 BP GO:0043457 regulation of cellular respiration 2/819 31/18670 0.3971 0.6001 0.4602 HIF1A/TRAP1 2 BP GO:0044319 wound healing, spreading of cells 2/819 31/18670 0.3971 0.6001 0.4602 CD151/MTOR 2 BP GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity 2/819 31/18670 0.3971 0.6001 0.4602 CCND2/MAPRE3 2 BP GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 2/819 31/18670 0.3971 0.6001 0.4602 HIP1R/DOK1 2 BP GO:0046471 phosphatidylglycerol metabolic process 2/819 31/18670 0.3971 0.6001 0.4602 LPGAT1/CDS2 2 BP GO:0048710 regulation of astrocyte differentiation 2/819 31/18670 0.3971 0.6001 0.4602 IL6ST/BIN1 2 BP GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 2/819 31/18670 0.3971 0.6001 0.4602 TGM2/LPAR1 2 BP GO:0086011 membrane repolarization during action potential 2/819 31/18670 0.3971 0.6001 0.4602 KCND3/ATP1B1 2 BP GO:0090505 epiboly involved in wound healing 2/819 31/18670 0.3971 0.6001 0.4602 CD151/MTOR 2 BP GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2/819 31/18670 0.3971 0.6001 0.4602 PTTG1IP/BCL2 2 BP GO:2000406 positive regulation of T cell migration 2/819 31/18670 0.3971 0.6001 0.4602 CXCL12/TNFRSF14 2 BP GO:0098727 maintenance of cell number 8/819 159/18670 0.3974 0.6003 0.4604 POLR2L/POLR2E/FZD7/LOXL2/STAT3/KLF4/FOXO3/SOX4 8 BP GO:0000281 mitotic cytokinesis 4/819 73/18670 0.399 0.6025 0.462 ESPL1/RASA1/CHMP2A/SPTBN1 4 BP GO:0009988 cell-cell recognition 4/819 73/18670 0.399 0.6025 0.462 FOLR3/FOLR2/SPA17/CCT7 4 BP GO:0034219 carbohydrate transmembrane transport 6/819 116/18670 0.3999 0.6036 0.4629 ENPP1/PIK3R1/GRB10/PRKCB/EDNRA/PTPN11 6 BP GO:0006836 neurotransmitter transport 13/819 269/18670 0.4005 0.6037 0.463 ATP2A2/PPFIA4/SV2A/SLC29A1/ITGB3/NAPA/GPM6B/RGS2/PRKCB/UNC13B/NAAA/ASIC1/PER2 13 BP GO:0045839 negative regulation of mitotic nuclear division 3/819 52/18670 0.4007 0.6037 0.463 BMP4/ANAPC15/IK 3 BP GO:0048168 regulation of neuronal synaptic plasticity 3/819 52/18670 0.4007 0.6037 0.463 EPHB2/RAB8A/UNC13B 3 BP GO:1902373 negative regulation of mRNA catabolic process 3/819 52/18670 0.4007 0.6037 0.463 HNRNPA0/ZFP36/MTOR 3 BP GO:2000649 regulation of sodium ion transmembrane transporter activity 3/819 52/18670 0.4007 0.6037 0.463 CAV3/ATP1B1/GPD1L 3 BP GO:2000677 regulation of transcription regulatory region DNA binding 3/819 52/18670 0.4007 0.6037 0.463 FOXC1/KLF4/PER2 3 BP GO:0061008 hepaticobiliary system development 7/819 138/18670 0.4025 0.6039 0.4632 ACO2/HMGCL/PHF2/QDPR/MET/ITGA2/HLX 7 BP GO:1903305 regulation of regulated secretory pathway 8/819 160/18670 0.4041 0.6039 0.4632 ATP2A2/ITGB2/ABR/NAPA/IL13RA2/PRKCB/IL4R/UNC13B 8 BP GO:0002702 positive regulation of production of molecular mediator of immune response 5/819 95/18670 0.4046 0.6039 0.4632 MAPK3/IL18R1/TNFRSF14/RSAD2/IL4R 5 BP GO:1903317 regulation of protein maturation 9/819 182/18670 0.4051 0.6039 0.4632 CD55/THBS1/C1S/MYH9/GSN/C1R/SPON1/PHB/SOX4 9 BP GO:0005996 monosaccharide metabolic process 14/819 292/18670 0.4053 0.6039 0.4632 ENPP1/GSTO1/SORD/OAS1/KAT2B/FBP1/PDK1/MTOR/BAD/PDK2/PGM1/PER2/TPI1/MDH2 14 BP GO:0035637 multicellular organismal signaling 10/819 204/18670 0.4056 0.6039 0.4632 ATP2A2/GJA1/NTRK2/GJC1/KCND3/ITPR3/ATP1B1/CACNA1C/ITGA2/BIN1 10 BP GO:0031398 positive regulation of protein ubiquitination 6/819 117/18670 0.4078 0.6039 0.4632 PIN1/ANGPT1/HSPA5/ARRB2/PTTG1IP/RCHY1 6 BP GO:0072078 nephron tubule morphogenesis 4/819 74/18670 0.409 0.6039 0.4632 MAGED1/BMP4/WNT11/BCL2 4 BP GO:1900182 positive regulation of protein localization to nucleus 4/819 74/18670 0.409 0.6039 0.4632 PIK3R1/CD2AP/PIK3R2/CCT7 4 BP GO:1903036 positive regulation of response to wounding 4/819 74/18670 0.409 0.6039 0.4632 THBS1/GRN/MYLK/MTOR 4 BP GO:0050715 positive regulation of cytokine secretion 7/819 139/18670 0.4097 0.6039 0.4632 MAPK3/POSTN/IL1RAP/TNFRSF14/IL4R/HTR2B/SPTBN1 7 BP GO:0010970 transport along microtubule 8/819 161/18670 0.4108 0.6039 0.4632 TRAK2/CLN3/RAB27B/HIF1A/SPG11/DYNC1I1/TERF2/MAP1A 8 BP GO:0099111 microtubule-based transport 8/819 161/18670 0.4108 0.6039 0.4632 TRAK2/CLN3/RAB27B/HIF1A/SPG11/DYNC1I1/TERF2/MAP1A 8 BP GO:0001894 tissue homeostasis 11/819 227/18670 0.4115 0.6039 0.4632 PLEKHM1/PRKCA/FOXC1/WWTR1/ITGB3/LIPA/EPAS1/TNFRSF11B/BCL2/TCIRG1/PTPN11 11 BP GO:0097164 ammonium ion metabolic process 10/819 205/18670 0.4116 0.6039 0.4632 PLA2G15/CLN3/PLA2G4C/ITGB2/CDS1/TGFB2/ASAH1/ENPP2/ALDH7A1/GRIN2A 10 BP GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis 3/819 53/18670 0.4126 0.6039 0.4632 THBS1/BMP4/ITGB1BP1 3 BP GO:0006968 cellular defense response 3/819 53/18670 0.4126 0.6039 0.4632 CCR3/TCIRG1/ITGB1 3 BP GO:0030195 negative regulation of blood coagulation 3/819 53/18670 0.4126 0.6039 0.4632 THBS1/FAP/PDGFA 3 BP GO:0032715 negative regulation of interleukin-6 production 3/819 53/18670 0.4126 0.6039 0.4632 ARRB2/GAS6/SOCS5 3 BP GO:0035065 regulation of histone acetylation 3/819 53/18670 0.4126 0.6039 0.4632 MAPK3/SNAI2/WBP2 3 BP GO:0045661 regulation of myoblast differentiation 3/819 53/18670 0.4126 0.6039 0.4632 BMP4/MAP3K5/PLCB1 3 BP GO:0045840 positive regulation of mitotic nuclear division 3/819 53/18670 0.4126 0.6039 0.4632 ESPL1/NSFL1C/SMC5 3 BP GO:0071320 cellular response to cAMP 3/819 53/18670 0.4126 0.6039 0.4632 HSPA5/RAPGEF1/EZR 3 BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 3/819 53/18670 0.4126 0.6039 0.4632 ESPL1/ANAPC15/IK 3 BP GO:1903307 positive regulation of regulated secretory pathway 3/819 53/18670 0.4126 0.6039 0.4632 ITGB2/IL4R/UNC13B 3 BP GO:0006505 GPI anchor metabolic process 2/819 32/18670 0.4127 0.6039 0.4632 PIGH/DPM2 2 BP GO:0008210 estrogen metabolic process 2/819 32/18670 0.4127 0.6039 0.4632 CYP1B1/CYP3A4 2 BP GO:0032814 regulation of natural killer cell activation 2/819 32/18670 0.4127 0.6039 0.4632 IL12A/GAS6 2 BP GO:0033006 regulation of mast cell activation involved in immune response 2/819 32/18670 0.4127 0.6039 0.4632 IL13RA2/IL4R 2 BP GO:0035510 DNA dealkylation 2/819 32/18670 0.4127 0.6039 0.4632 APOBEC3B/APOBEC3C 2 BP GO:0042311 vasodilation 2/819 32/18670 0.4127 0.6039 0.4632 ITGA1/RGS2 2 BP GO:0046949 fatty-acyl-CoA biosynthetic process 2/819 32/18670 0.4127 0.6039 0.4632 ELOVL2/TECR 2 BP GO:0048841 regulation of axon extension involved in axon guidance 2/819 32/18670 0.4127 0.6039 0.4632 CXCL12/NRP1 2 BP GO:0060325 face morphogenesis 2/819 32/18670 0.4127 0.6039 0.4632 COL1A1/PTPN11 2 BP GO:0060674 placenta blood vessel development 2/819 32/18670 0.4127 0.6039 0.4632 SOCS3/TMED2 2 BP GO:0061311 cell surface receptor signaling pathway involved in heart development 2/819 32/18670 0.4127 0.6039 0.4632 BMP4/SNAI2 2 BP GO:0071353 cellular response to interleukin-4 2/819 32/18670 0.4127 0.6039 0.4632 HSPA5/IL4R 2 BP GO:0090504 epiboly 2/819 32/18670 0.4127 0.6039 0.4632 CD151/MTOR 2 BP GO:1901661 quinone metabolic process 2/819 32/18670 0.4127 0.6039 0.4632 FDXR/COQ9 2 BP GO:1901976 regulation of cell cycle checkpoint 2/819 32/18670 0.4127 0.6039 0.4632 THOC1/ANAPC15 2 BP GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2/819 32/18670 0.4127 0.6039 0.4632 BCL2L1/NCK1 2 BP GO:1990266 neutrophil migration 6/819 118/18670 0.4157 0.6039 0.4632 THBS4/ITGA1/ITGB2/PDE4B/BST1/TGFB2 6 BP GO:0002468 dendritic cell antigen processing and presentation 1/819 12/18670 0.4164 0.6039 0.4632 THBS1 1 BP GO:0002551 mast cell chemotaxis 1/819 12/18670 0.4164 0.6039 0.4632 VEGFC 1 BP GO:0002921 negative regulation of humoral immune response 1/819 12/18670 0.4164 0.6039 0.4632 CD55 1 BP GO:0003161 cardiac conduction system development 1/819 12/18670 0.4164 0.6039 0.4632 MAML1 1 BP GO:0003207 cardiac chamber formation 1/819 12/18670 0.4164 0.6039 0.4632 SOX4 1 BP GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis 1/819 12/18670 0.4164 0.6039 0.4632 BMP4 1 BP GO:0006068 ethanol catabolic process 1/819 12/18670 0.4164 0.6039 0.4632 ALDH2 1 BP GO:0006563 L-serine metabolic process 1/819 12/18670 0.4164 0.6039 0.4632 SERINC5 1 BP GO:0006828 manganese ion transport 1/819 12/18670 0.4164 0.6039 0.4632 TRPC6 1 BP GO:0006983 ER overload response 1/819 12/18670 0.4164 0.6039 0.4632 HSPA5 1 BP GO:0008228 opsonization 1/819 12/18670 0.4164 0.6039 0.4632 PTX3 1 BP GO:0009086 methionine biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 MTHFD1 1 BP GO:0009265 2'-deoxyribonucleotide biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 GUK1 1 BP GO:0009642 response to light intensity 1/819 12/18670 0.4164 0.6039 0.4632 CAT 1 BP GO:0014029 neural crest formation 1/819 12/18670 0.4164 0.6039 0.4632 NOLC1 1 BP GO:0015816 glycine transport 1/819 12/18670 0.4164 0.6039 0.4632 RGS2 1 BP GO:0015867 ATP transport 1/819 12/18670 0.4164 0.6039 0.4632 GJA1 1 BP GO:0016081 synaptic vesicle docking 1/819 12/18670 0.4164 0.6039 0.4632 UNC13B 1 BP GO:0016188 synaptic vesicle maturation 1/819 12/18670 0.4164 0.6039 0.4632 UNC13B 1 BP GO:0019336 phenol-containing compound catabolic process 1/819 12/18670 0.4164 0.6039 0.4632 FAH 1 BP GO:0019374 galactolipid metabolic process 1/819 12/18670 0.4164 0.6039 0.4632 CLN3 1 BP GO:0030157 pancreatic juice secretion 1/819 12/18670 0.4164 0.6039 0.4632 NR1H3 1 BP GO:0031126 snoRNA 3'-end processing 1/819 12/18670 0.4164 0.6039 0.4632 EXOSC2 1 BP GO:0032252 secretory granule localization 1/819 12/18670 0.4164 0.6039 0.4632 MYO5A 1 BP GO:0033523 histone H2B ubiquitination 1/819 12/18670 0.4164 0.6039 0.4632 UBE2E1 1 BP GO:0033700 phospholipid efflux 1/819 12/18670 0.4164 0.6039 0.4632 ABCG1 1 BP GO:0034086 maintenance of sister chromatid cohesion 1/819 12/18670 0.4164 0.6039 0.4632 SMC5 1 BP GO:0034088 maintenance of mitotic sister chromatid cohesion 1/819 12/18670 0.4164 0.6039 0.4632 SMC5 1 BP GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter 1/819 12/18670 0.4164 0.6039 0.4632 SUPT4H1 1 BP GO:0034497 protein localization to phagophore assembly site 1/819 12/18670 0.4164 0.6039 0.4632 PIK3C3 1 BP GO:0035630 bone mineralization involved in bone maturation 1/819 12/18670 0.4164 0.6039 0.4632 GREM1 1 BP GO:0036005 response to macrophage colony-stimulating factor 1/819 12/18670 0.4164 0.6039 0.4632 DOK1 1 BP GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 1/819 12/18670 0.4164 0.6039 0.4632 DOK1 1 BP GO:0038180 nerve growth factor signaling pathway 1/819 12/18670 0.4164 0.6039 0.4632 RAPGEF1 1 BP GO:0042118 endothelial cell activation 1/819 12/18670 0.4164 0.6039 0.4632 TGFBR1 1 BP GO:0042416 dopamine biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 TGFB2 1 BP GO:0042659 regulation of cell fate specification 1/819 12/18670 0.4164 0.6039 0.4632 FZD7 1 BP GO:0043476 pigment accumulation 1/819 12/18670 0.4164 0.6039 0.4632 RAB32 1 BP GO:0043482 cellular pigment accumulation 1/819 12/18670 0.4164 0.6039 0.4632 RAB32 1 BP GO:0045161 neuronal ion channel clustering 1/819 12/18670 0.4164 0.6039 0.4632 MYOC 1 BP GO:0045579 positive regulation of B cell differentiation 1/819 12/18670 0.4164 0.6039 0.4632 BAD 1 BP GO:0046385 deoxyribose phosphate biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 GUK1 1 BP GO:0046520 sphingoid biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 ASAH1 1 BP GO:0046541 saliva secretion 1/819 12/18670 0.4164 0.6039 0.4632 KCNN4 1 BP GO:0046929 negative regulation of neurotransmitter secretion 1/819 12/18670 0.4164 0.6039 0.4632 ASIC1 1 BP GO:0048934 peripheral nervous system neuron differentiation 1/819 12/18670 0.4164 0.6039 0.4632 NTRK2 1 BP GO:0048935 peripheral nervous system neuron development 1/819 12/18670 0.4164 0.6039 0.4632 NTRK2 1 BP GO:0050910 detection of mechanical stimulus involved in sensory perception of sound 1/819 12/18670 0.4164 0.6039 0.4632 COL11A1 1 BP GO:0051095 regulation of helicase activity 1/819 12/18670 0.4164 0.6039 0.4632 IFIT1 1 BP GO:0051132 NK T cell activation 1/819 12/18670 0.4164 0.6039 0.4632 IL12A 1 BP GO:0051798 positive regulation of hair follicle development 1/819 12/18670 0.4164 0.6039 0.4632 TGFB2 1 BP GO:0051956 negative regulation of amino acid transport 1/819 12/18670 0.4164 0.6039 0.4632 RGS2 1 BP GO:0052803 imidazole-containing compound metabolic process 1/819 12/18670 0.4164 0.6039 0.4632 MTHFD1 1 BP GO:0060019 radial glial cell differentiation 1/819 12/18670 0.4164 0.6039 0.4632 STAT3 1 BP GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway 1/819 12/18670 0.4164 0.6039 0.4632 RAPGEF1 1 BP GO:0060442 branching involved in prostate gland morphogenesis 1/819 12/18670 0.4164 0.6039 0.4632 BMP4 1 BP GO:0060453 regulation of gastric acid secretion 1/819 12/18670 0.4164 0.6039 0.4632 HIP1R 1 BP GO:0060670 branching involved in labyrinthine layer morphogenesis 1/819 12/18670 0.4164 0.6039 0.4632 SOCS3 1 BP GO:0060707 trophoblast giant cell differentiation 1/819 12/18670 0.4164 0.6039 0.4632 SOCS3 1 BP GO:0070202 regulation of establishment of protein localization to chromosome 1/819 12/18670 0.4164 0.6039 0.4632 CCT7 1 BP GO:0070486 leukocyte aggregation 1/819 12/18670 0.4164 0.6039 0.4632 HAS2 1 BP GO:0070493 thrombin-activated receptor signaling pathway 1/819 12/18670 0.4164 0.6039 0.4632 MET 1 BP GO:0070572 positive regulation of neuron projection regeneration 1/819 12/18670 0.4164 0.6039 0.4632 GRN 1 BP GO:0070586 cell-cell adhesion involved in gastrulation 1/819 12/18670 0.4164 0.6039 0.4632 KLF4 1 BP GO:0070601 centromeric sister chromatid cohesion 1/819 12/18670 0.4164 0.6039 0.4632 PPP2R1A 1 BP GO:0071073 positive regulation of phospholipid biosynthetic process 1/819 12/18670 0.4164 0.6039 0.4632 HTR2B 1 BP GO:0071257 cellular response to electrical stimulus 1/819 12/18670 0.4164 0.6039 0.4632 PALM 1 BP GO:0071472 cellular response to salt stress 1/819 12/18670 0.4164 0.6039 0.4632 XRCC6 1 BP GO:0071481 cellular response to X-ray 1/819 12/18670 0.4164 0.6039 0.4632 XRCC6 1 BP GO:0072178 nephric duct morphogenesis 1/819 12/18670 0.4164 0.6039 0.4632 BMP4 1 BP GO:0072540 T-helper 17 cell lineage commitment 1/819 12/18670 0.4164 0.6039 0.4632 STAT3 1 BP GO:0072578 neurotransmitter-gated ion channel clustering 1/819 12/18670 0.4164 0.6039 0.4632 GLRB 1 BP GO:0072697 protein localization to cell cortex 1/819 12/18670 0.4164 0.6039 0.4632 EZR 1 BP GO:0090520 sphingolipid mediated signaling pathway 1/819 12/18670 0.4164 0.6039 0.4632 EZR 1 BP GO:0097104 postsynaptic membrane assembly 1/819 12/18670 0.4164 0.6039 0.4632 EPHB2 1 BP GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1/819 12/18670 0.4164 0.6039 0.4632 NCK1 1 BP GO:0097531 mast cell migration 1/819 12/18670 0.4164 0.6039 0.4632 VEGFC 1 BP GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration 1/819 12/18670 0.4164 0.6039 0.4632 MYO5A 1 BP GO:0099638 endosome to plasma membrane protein transport 1/819 12/18670 0.4164 0.6039 0.4632 RAB8A 1 BP GO:0150065 regulation of deacetylase activity 1/819 12/18670 0.4164 0.6039 0.4632 PRKD1 1 BP GO:1900044 regulation of protein K63-linked ubiquitination 1/819 12/18670 0.4164 0.6039 0.4632 SASH1 1 BP GO:1900165 negative regulation of interleukin-6 secretion 1/819 12/18670 0.4164 0.6039 0.4632 GAS6 1 BP GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter 1/819 12/18670 0.4164 0.6039 0.4632 KAT2B 1 BP GO:1901387 positive regulation of voltage-gated calcium channel activity 1/819 12/18670 0.4164 0.6039 0.4632 STAC 1 BP GO:1902950 regulation of dendritic spine maintenance 1/819 12/18670 0.4164 0.6039 0.4632 GRIN2B 1 BP GO:1903894 regulation of IRE1-mediated unfolded protein response 1/819 12/18670 0.4164 0.6039 0.4632 HSPA5 1 BP GO:1903909 regulation of receptor clustering 1/819 12/18670 0.4164 0.6039 0.4632 GSN 1 BP GO:1904181 positive regulation of membrane depolarization 1/819 12/18670 0.4164 0.6039 0.4632 MYOC 1 BP GO:1904424 regulation of GTP binding 1/819 12/18670 0.4164 0.6039 0.4632 MET 1 BP GO:1904816 positive regulation of protein localization to chromosome, telomeric region 1/819 12/18670 0.4164 0.6039 0.4632 CCT7 1 BP GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1/819 12/18670 0.4164 0.6039 0.4632 FZD1 1 BP GO:1905522 negative regulation of macrophage migration 1/819 12/18670 0.4164 0.6039 0.4632 EMILIN1 1 BP GO:1905666 regulation of protein localization to endosome 1/819 12/18670 0.4164 0.6039 0.4632 EZR 1 BP GO:1990173 protein localization to nucleoplasm 1/819 12/18670 0.4164 0.6039 0.4632 CCT7 1 BP GO:2000121 regulation of removal of superoxide radicals 1/819 12/18670 0.4164 0.6039 0.4632 FBLN5 1 BP GO:2000232 regulation of rRNA processing 1/819 12/18670 0.4164 0.6039 0.4632 WDR43 1 BP GO:2000344 positive regulation of acrosome reaction 1/819 12/18670 0.4164 0.6039 0.4632 PLCB1 1 BP GO:2001053 regulation of mesenchymal cell apoptotic process 1/819 12/18670 0.4164 0.6039 0.4632 HIF1A 1 BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 9/819 184/18670 0.4177 0.6057 0.4645 NACC2/CCND2/PRMT1/KLF4/BCL2/PLCB1/SOX4/CTDSP2/CDKN2A 9 BP GO:0007422 peripheral nervous system development 4/819 75/18670 0.419 0.6073 0.4657 MYOC/NTRK2/PMP22/NAB1 4 BP GO:0021536 diencephalon development 4/819 75/18670 0.419 0.6073 0.4657 BMP4/NRP1/UQCRQ/NRP2 4 BP GO:0060996 dendritic spine development 5/819 97/18670 0.4221 0.6116 0.469 EPHB2/ARF4/LPAR1/MTOR/CAMK1 5 BP GO:0070585 protein localization to mitochondrion 7/819 141/18670 0.4242 0.6138 0.4707 TOMM34/VPS11/HAX1/NMT1/BAD/BCL2/LMAN1 7 BP GO:0045931 positive regulation of mitotic cell cycle 8/819 163/18670 0.4242 0.6138 0.4707 ESPL1/PRKCA/NSFL1C/HSPA2/CCND2/SMC5/PLCB1/PTPN11 8 BP GO:0006336 DNA replication-independent nucleosome assembly 3/819 54/18670 0.4244 0.6138 0.4707 ITGB3BP/POLE3/ASF1A 3 BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3/819 54/18670 0.4244 0.6138 0.4707 ESPL1/ANAPC15/IK 3 BP GO:0010524 positive regulation of calcium ion transport into cytosol 3/819 54/18670 0.4244 0.6138 0.4707 GSTO1/CEMIP/THY1 3 BP GO:0043392 negative regulation of DNA binding 3/819 54/18670 0.4244 0.6138 0.4707 HABP4/JAK2/PER2 3 BP GO:0051290 protein heterotetramerization 3/819 54/18670 0.4244 0.6138 0.4707 XRCC6/GRIN2B/RRM2 3 BP GO:0006260 DNA replication 13/819 274/18670 0.4263 0.6154 0.472 THOC1/PRIM2/RFC3/POLE3/RPA3/DNAJC2/TERF2/PRIM1/RRM2/MAP2K4/PPP2R1A/POLD2/HMGA1 13 BP GO:0002717 positive regulation of natural killer cell mediated immunity 2/819 33/18670 0.428 0.6154 0.472 MICB/IL12A 2 BP GO:0006471 protein ADP-ribosylation 2/819 33/18670 0.428 0.6154 0.472 ARF4/KAT2B 2 BP GO:0006891 intra-Golgi vesicle-mediated transport 2/819 33/18670 0.428 0.6154 0.472 GOSR2/NAPA 2 BP GO:0010737 protein kinase A signaling 2/819 33/18670 0.428 0.6154 0.472 AKAP1/EZR 2 BP GO:0014072 response to isoquinoline alkaloid 2/819 33/18670 0.428 0.6154 0.472 ADCY8/MTOR 2 BP GO:0019692 deoxyribose phosphate metabolic process 2/819 33/18670 0.428 0.6154 0.472 MBD4/GUK1 2 BP GO:0030851 granulocyte differentiation 2/819 33/18670 0.428 0.6154 0.472 LBR/HAX1 2 BP GO:0035115 embryonic forelimb morphogenesis 2/819 33/18670 0.428 0.6154 0.472 TFAP2A/CACNA1C 2 BP GO:0036314 response to sterol 2/819 33/18670 0.428 0.6154 0.472 GRAMD1B/TGFBR1 2 BP GO:0040001 establishment of mitotic spindle localization 2/819 33/18670 0.428 0.6154 0.472 ESPL1/NSFL1C 2 BP GO:0042755 eating behavior 2/819 33/18670 0.428 0.6154 0.472 STAT3/MTOR 2 BP GO:0043278 response to morphine 2/819 33/18670 0.428 0.6154 0.472 ADCY8/MTOR 2 BP GO:0046633 alpha-beta T cell proliferation 2/819 33/18670 0.428 0.6154 0.472 CD55/TNFRSF14 2 BP GO:0048011 neurotrophin TRK receptor signaling pathway 2/819 33/18670 0.428 0.6154 0.472 NTRK2/PTPN11 2 BP GO:0048536 spleen development 2/819 33/18670 0.428 0.6154 0.472 BCL2/PKN1 2 BP GO:0048854 brain morphogenesis 2/819 33/18670 0.428 0.6154 0.472 FZD6/FOXO3 2 BP GO:0070232 regulation of T cell apoptotic process 2/819 33/18670 0.428 0.6154 0.472 BMP4/HIF1A 2 BP GO:0099084 postsynaptic specialization organization 2/819 33/18670 0.428 0.6154 0.472 IL1RAP/GAP43 2 BP GO:1901186 positive regulation of ERBB signaling pathway 2/819 33/18670 0.428 0.6154 0.472 HIP1R/DOK1 2 BP GO:1901380 negative regulation of potassium ion transmembrane transport 2/819 33/18670 0.428 0.6154 0.472 CAV3/BIN1 2 BP GO:1902692 regulation of neuroblast proliferation 2/819 33/18670 0.428 0.6154 0.472 VEGFC/HIF1A 2 BP GO:0061045 negative regulation of wound healing 4/819 76/18670 0.4289 0.6162 0.4726 THBS1/GJA1/FAP/PDGFA 4 BP GO:0072088 nephron epithelium morphogenesis 4/819 76/18670 0.4289 0.6162 0.4726 MAGED1/BMP4/WNT11/BCL2 4 BP GO:0009119 ribonucleoside metabolic process 5/819 98/18670 0.4308 0.6162 0.4726 NME3/APOBEC3B/GUK1/APOBEC3C/CTPS1 5 BP GO:0050764 regulation of phagocytosis 5/819 98/18670 0.4308 0.6162 0.4726 ABR/RAPGEF1/GAS6/ITGA2/PTX3 5 BP GO:0099175 regulation of postsynapse organization 5/819 98/18670 0.4308 0.6162 0.4726 IL1RAP/GAP43/ARF4/GRIN2B/NRP2 5 BP GO:0007088 regulation of mitotic nuclear division 8/819 164/18670 0.4309 0.6162 0.4726 ESPL1/PIN1/BMP4/NSFL1C/SMC5/CHMP2A/ANAPC15/IK 8 BP GO:0035821 modification of morphology or physiology of other organism 8/819 164/18670 0.4309 0.6162 0.4726 BCL2L1/PPIB/CHD1/IFI27/BAD/FBXL2/PTX3/KPNA3 8 BP GO:0034724 DNA replication-independent nucleosome organization 3/819 55/18670 0.4362 0.6162 0.4726 ITGB3BP/POLE3/ASF1A 3 BP GO:0042304 regulation of fatty acid biosynthetic process 3/819 55/18670 0.4362 0.6162 0.4726 LPGAT1/NR1H2/NR1H3 3 BP GO:0048016 inositol phosphate-mediated signaling 3/819 55/18670 0.4362 0.6162 0.4726 CIB1/ITPR3/MTOR 3 BP GO:0061098 positive regulation of protein tyrosine kinase activity 3/819 55/18670 0.4362 0.6162 0.4726 NTRK2/CD24/GAS6 3 BP GO:0048167 regulation of synaptic plasticity 9/819 187/18670 0.4365 0.6162 0.4726 ADCY8/EPHB2/NTRK2/ITPR3/GRIN2B/RAB8A/UNC13B/MAP1A/GRIN2A 9 BP GO:0016575 histone deacetylation 4/819 77/18670 0.4388 0.6162 0.4726 NACC2/PRKD1/PHB/PER2 4 BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 4/819 77/18670 0.4388 0.6162 0.4726 IL18R1/SASH1/COPS8/CHI3L1 4 BP GO:0048675 axon extension 6/819 121/18670 0.4392 0.6162 0.4726 CXCL12/NRP1/SPG11/TWF2/NRP2/ITGB1 6 BP GO:0050707 regulation of cytokine secretion 10/819 210/18670 0.4413 0.6162 0.4726 MAPK3/POSTN/IL1RAP/ANGPT1/TNFRSF14/GAS6/IL4R/HTR2B/SPTBN1/EZR 10 BP GO:0000054 ribosomal subunit export from nucleus 1/819 13/18670 0.442 0.6162 0.4726 RRS1 1 BP GO:0001765 membrane raft assembly 1/819 13/18670 0.442 0.6162 0.4726 CAV3 1 BP GO:0001845 phagolysosome assembly 1/819 13/18670 0.442 0.6162 0.4726 SPG11 1 BP GO:0001886 endothelial cell morphogenesis 1/819 13/18670 0.442 0.6162 0.4726 MET 1 BP GO:0002281 macrophage activation involved in immune response 1/819 13/18670 0.442 0.6162 0.4726 GRN 1 BP GO:0002430 complement receptor mediated signaling pathway 1/819 13/18670 0.442 0.6162 0.4726 FPR1 1 BP GO:0002679 respiratory burst involved in defense response 1/819 13/18670 0.442 0.6162 0.4726 GRN 1 BP GO:0005513 detection of calcium ion 1/819 13/18670 0.442 0.6162 0.4726 KCNMB1 1 BP GO:0006012 galactose metabolic process 1/819 13/18670 0.442 0.6162 0.4726 PGM1 1 BP GO:0006384 transcription initiation from RNA polymerase III promoter 1/819 13/18670 0.442 0.6162 0.4726 SNAPC5 1 BP GO:0006670 sphingosine metabolic process 1/819 13/18670 0.442 0.6162 0.4726 ASAH1 1 BP GO:0006707 cholesterol catabolic process 1/819 13/18670 0.442 0.6162 0.4726 CYP27A1 1 BP GO:0006995 cellular response to nitrogen starvation 1/819 13/18670 0.442 0.6162 0.4726 MAP1LC3B 1 BP GO:0009143 nucleoside triphosphate catabolic process 1/819 13/18670 0.442 0.6162 0.4726 ENPP1 1 BP GO:0009223 pyrimidine deoxyribonucleotide catabolic process 1/819 13/18670 0.442 0.6162 0.4726 MBD4 1 BP GO:0009313 oligosaccharide catabolic process 1/819 13/18670 0.442 0.6162 0.4726 GM2A 1 BP GO:0009650 UV protection 1/819 13/18670 0.442 0.6162 0.4726 CAT 1 BP GO:0010454 negative regulation of cell fate commitment 1/819 13/18670 0.442 0.6162 0.4726 FZD7 1 BP GO:0010838 positive regulation of keratinocyte proliferation 1/819 13/18670 0.442 0.6162 0.4726 HAS2 1 BP GO:0010872 regulation of cholesterol esterification 1/819 13/18670 0.442 0.6162 0.4726 ABCG1 1 BP GO:0010940 positive regulation of necrotic cell death 1/819 13/18670 0.442 0.6162 0.4726 HEBP2 1 BP GO:0015812 gamma-aminobutyric acid transport 1/819 13/18670 0.442 0.6162 0.4726 SV2A 1 BP GO:0016127 sterol catabolic process 1/819 13/18670 0.442 0.6162 0.4726 CYP27A1 1 BP GO:0016558 protein import into peroxisome matrix 1/819 13/18670 0.442 0.6162 0.4726 PEX7 1 BP GO:0019511 peptidyl-proline hydroxylation 1/819 13/18670 0.442 0.6162 0.4726 P4HA1 1 BP GO:0021794 thalamus development 1/819 13/18670 0.442 0.6162 0.4726 UQCRQ 1 BP GO:0021978 telencephalon regionalization 1/819 13/18670 0.442 0.6162 0.4726 BMP4 1 BP GO:0030007 cellular potassium ion homeostasis 1/819 13/18670 0.442 0.6162 0.4726 ATP1B1 1 BP GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1/819 13/18670 0.442 0.6162 0.4726 EMILIN1 1 BP GO:0031115 negative regulation of microtubule polymerization 1/819 13/18670 0.442 0.6162 0.4726 FKBP4 1 BP GO:0031274 positive regulation of pseudopodium assembly 1/819 13/18670 0.442 0.6162 0.4726 CDC42EP1 1 BP GO:0031953 negative regulation of protein autophosphorylation 1/819 13/18670 0.442 0.6162 0.4726 ENPP1 1 BP GO:0032488 Cdc42 protein signal transduction 1/819 13/18670 0.442 0.6162 0.4726 NRP1 1 BP GO:0032754 positive regulation of interleukin-5 production 1/819 13/18670 0.442 0.6162 0.4726 IL1RAP 1 BP GO:0032823 regulation of natural killer cell differentiation 1/819 13/18670 0.442 0.6162 0.4726 GAS6 1 BP GO:0033004 negative regulation of mast cell activation 1/819 13/18670 0.442 0.6162 0.4726 IL13RA2 1 BP GO:0033127 regulation of histone phosphorylation 1/819 13/18670 0.442 0.6162 0.4726 MAPK3 1 BP GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway 1/819 13/18670 0.442 0.6162 0.4726 STRN3 1 BP GO:0033605 positive regulation of catecholamine secretion 1/819 13/18670 0.442 0.6162 0.4726 CXCL12 1 BP GO:0033750 ribosome localization 1/819 13/18670 0.442 0.6162 0.4726 RRS1 1 BP GO:0034374 low-density lipoprotein particle remodeling 1/819 13/18670 0.442 0.6162 0.4726 ABCG1 1 BP GO:0034969 histone arginine methylation 1/819 13/18670 0.442 0.6162 0.4726 PRMT1 1 BP GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway 1/819 13/18670 0.442 0.6162 0.4726 P2RY2 1 BP GO:0035627 ceramide transport 1/819 13/18670 0.442 0.6162 0.4726 PLTP 1 BP GO:0035745 T-helper 2 cell cytokine production 1/819 13/18670 0.442 0.6162 0.4726 RSAD2 1 BP GO:0036109 alpha-linolenic acid metabolic process 1/819 13/18670 0.442 0.6162 0.4726 ELOVL2 1 BP GO:0042178 xenobiotic catabolic process 1/819 13/18670 0.442 0.6162 0.4726 GSTO1 1 BP GO:0042415 norepinephrine metabolic process 1/819 13/18670 0.442 0.6162 0.4726 EPAS1 1 BP GO:0042538 hyperosmotic salinity response 1/819 13/18670 0.442 0.6162 0.4726 XRCC6 1 BP GO:0042635 positive regulation of hair cycle 1/819 13/18670 0.442 0.6162 0.4726 TGFB2 1 BP GO:0043247 telomere maintenance in response to DNA damage 1/819 13/18670 0.442 0.6162 0.4726 TERF2 1 BP GO:0043562 cellular response to nitrogen levels 1/819 13/18670 0.442 0.6162 0.4726 MAP1LC3B 1 BP GO:0043970 histone H3-K9 acetylation 1/819 13/18670 0.442 0.6162 0.4726 KAT2B 1 BP GO:0045006 DNA deamination 1/819 13/18670 0.442 0.6162 0.4726 APOBEC3C 1 BP GO:0045779 negative regulation of bone resorption 1/819 13/18670 0.442 0.6162 0.4726 TNFRSF11B 1 BP GO:0046040 IMP metabolic process 1/819 13/18670 0.442 0.6162 0.4726 GART 1 BP GO:0046831 regulation of RNA export from nucleus 1/819 13/18670 0.442 0.6162 0.4726 NUP153 1 BP GO:0047484 regulation of response to osmotic stress 1/819 13/18670 0.442 0.6162 0.4726 BAD 1 BP GO:0048875 chemical homeostasis within a tissue 1/819 13/18670 0.442 0.6162 0.4726 EPAS1 1 BP GO:0050722 regulation of interleukin-1 beta biosynthetic process 1/819 13/18670 0.442 0.6162 0.4726 JAK2 1 BP GO:0050746 regulation of lipoprotein metabolic process 1/819 13/18670 0.442 0.6162 0.4726 ITGB3 1 BP GO:0051001 negative regulation of nitric-oxide synthase activity 1/819 13/18670 0.442 0.6162 0.4726 CAV3 1 BP GO:0051315 attachment of mitotic spindle microtubules to kinetochore 1/819 13/18670 0.442 0.6162 0.4726 KIF2C 1 BP GO:0060100 positive regulation of phagocytosis, engulfment 1/819 13/18670 0.442 0.6162 0.4726 ITGA2 1 BP GO:0060123 regulation of growth hormone secretion 1/819 13/18670 0.442 0.6162 0.4726 PTPN11 1 BP GO:0060312 regulation of blood vessel remodeling 1/819 13/18670 0.442 0.6162 0.4726 ABR 1 BP GO:0060340 positive regulation of type I interferon-mediated signaling pathway 1/819 13/18670 0.442 0.6162 0.4726 IRF7 1 BP GO:0060347 heart trabecula formation 1/819 13/18670 0.442 0.6162 0.4726 CAV3 1 BP GO:0060576 intestinal epithelial cell development 1/819 13/18670 0.442 0.6162 0.4726 HIF1A 1 BP GO:0060712 spongiotrophoblast layer development 1/819 13/18670 0.442 0.6162 0.4726 SOCS3 1 BP GO:0061029 eyelid development in camera-type eye 1/819 13/18670 0.442 0.6162 0.4726 TFAP2A 1 BP GO:0061469 regulation of type B pancreatic cell proliferation 1/819 13/18670 0.442 0.6162 0.4726 NUPR1 1 BP GO:0061478 response to platelet aggregation inhibitor 1/819 13/18670 0.442 0.6162 0.4726 ADCY8 1 BP GO:0070071 proton-transporting two-sector ATPase complex assembly 1/819 13/18670 0.442 0.6162 0.4726 TM9SF4 1 BP GO:0070914 UV-damage excision repair 1/819 13/18670 0.442 0.6162 0.4726 XPC 1 BP GO:0071285 cellular response to lithium ion 1/819 13/18670 0.442 0.6162 0.4726 ADCY7 1 BP GO:0071287 cellular response to manganese ion 1/819 13/18670 0.442 0.6162 0.4726 HSPA5 1 BP GO:0071696 ectodermal placode development 1/819 13/18670 0.442 0.6162 0.4726 NRP1 1 BP GO:0071872 cellular response to epinephrine stimulus 1/819 13/18670 0.442 0.6162 0.4726 PDE4B 1 BP GO:0072044 collecting duct development 1/819 13/18670 0.442 0.6162 0.4726 BMP4 1 BP GO:0090399 replicative senescence 1/819 13/18670 0.442 0.6162 0.4726 CDKN2A 1 BP GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 1/819 13/18670 0.442 0.6162 0.4726 SLC35D2 1 BP GO:0090713 immunological memory process 1/819 13/18670 0.442 0.6162 0.4726 TNFRSF14 1 BP GO:0098712 L-glutamate import across plasma membrane 1/819 13/18670 0.442 0.6162 0.4726 PER2 1 BP GO:0099633 protein localization to postsynaptic specialization membrane 1/819 13/18670 0.442 0.6162 0.4726 GPC4 1 BP GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 1/819 13/18670 0.442 0.6162 0.4726 GPC4 1 BP GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity 1/819 13/18670 0.442 0.6162 0.4726 LARS2 1 BP GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response 1/819 13/18670 0.442 0.6162 0.4726 PIK3R1 1 BP GO:1901160 primary amino compound metabolic process 1/819 13/18670 0.442 0.6162 0.4726 GRIN2A 1 BP GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I 1/819 13/18670 0.442 0.6162 0.4726 MTOR 1 BP GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 1/819 13/18670 0.442 0.6162 0.4726 BMP4 1 BP GO:1902902 negative regulation of autophagosome assembly 1/819 13/18670 0.442 0.6162 0.4726 NUPR1 1 BP GO:1904293 negative regulation of ERAD pathway 1/819 13/18670 0.442 0.6162 0.4726 UBE2J1 1 BP GO:1905155 positive regulation of membrane invagination 1/819 13/18670 0.442 0.6162 0.4726 ITGA2 1 BP GO:2000194 regulation of female gonad development 1/819 13/18670 0.442 0.6162 0.4726 NUPR1 1 BP GO:0051783 regulation of nuclear division 9/819 188/18670 0.4428 0.6162 0.4726 ESPL1/PIN1/BMP4/NSFL1C/SMC5/CHMP2A/PLCB1/ANAPC15/IK 9 BP GO:0007094 mitotic spindle assembly checkpoint 2/819 34/18670 0.4432 0.6162 0.4726 ANAPC15/IK 2 BP GO:0009164 nucleoside catabolic process 2/819 34/18670 0.4432 0.6162 0.4726 APOBEC3B/APOBEC3C 2 BP GO:0010765 positive regulation of sodium ion transport 2/819 34/18670 0.4432 0.6162 0.4726 ATP1B1/GPD1L 2 BP GO:0031577 spindle checkpoint 2/819 34/18670 0.4432 0.6162 0.4726 ANAPC15/IK 2 BP GO:0033120 positive regulation of RNA splicing 2/819 34/18670 0.4432 0.6162 0.4726 PIK3R1/HABP4 2 BP GO:0043094 cellular metabolic compound salvage 2/819 34/18670 0.4432 0.6162 0.4726 TK2/GMPR 2 BP GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 2/819 34/18670 0.4432 0.6162 0.4726 SNAI2/PTTG1IP 2 BP GO:0045920 negative regulation of exocytosis 2/819 34/18670 0.4432 0.6162 0.4726 ABR/IL13RA2 2 BP GO:0070670 response to interleukin-4 2/819 34/18670 0.4432 0.6162 0.4726 HSPA5/IL4R 2 BP GO:0070884 regulation of calcineurin-NFAT signaling cascade 2/819 34/18670 0.4432 0.6162 0.4726 CIB1/MTOR 2 BP GO:0071173 spindle assembly checkpoint 2/819 34/18670 0.4432 0.6162 0.4726 ANAPC15/IK 2 BP GO:0071174 mitotic spindle checkpoint 2/819 34/18670 0.4432 0.6162 0.4726 ANAPC15/IK 2 BP GO:0071868 cellular response to monoamine stimulus 2/819 34/18670 0.4432 0.6162 0.4726 MAPK3/PDE4B 2 BP GO:0071870 cellular response to catecholamine stimulus 2/819 34/18670 0.4432 0.6162 0.4726 MAPK3/PDE4B 2 BP GO:0097009 energy homeostasis 2/819 34/18670 0.4432 0.6162 0.4726 PRCP/STAT3 2 BP GO:0106056 regulation of calcineurin-mediated signaling 2/819 34/18670 0.4432 0.6162 0.4726 CIB1/MTOR 2 BP GO:0140115 export across plasma membrane 2/819 34/18670 0.4432 0.6162 0.4726 KCND3/ATP1B1 2 BP GO:0006475 internal protein amino acid acetylation 8/819 166/18670 0.4443 0.6176 0.4737 MAPK3/KAT2B/POLE3/SNAI2/WBP2/JADE2/MDH2/CREBBP 8 BP GO:0030534 adult behavior 7/819 144/18670 0.4457 0.6195 0.4751 CTNS/CXCL12/CHL1/TMOD1/EPS8/ARRB2/GLRB 7 BP GO:0034508 centromere complex assembly 3/819 56/18670 0.4478 0.6214 0.4765 ITGB3BP/POLE3/POGZ 3 BP GO:0044784 metaphase/anaphase transition of cell cycle 3/819 56/18670 0.4478 0.6214 0.4765 ESPL1/ANAPC15/IK 3 BP GO:0048488 synaptic vesicle endocytosis 3/819 56/18670 0.4478 0.6214 0.4765 SH3GL2/RAB27B/KIAA1107 3 BP GO:0070936 protein K48-linked ubiquitination 3/819 56/18670 0.4478 0.6214 0.4765 UBE2G1/IFI27/UBE2E1 3 BP GO:0140238 presynaptic endocytosis 3/819 56/18670 0.4478 0.6214 0.4765 SH3GL2/RAB27B/KIAA1107 3 BP GO:0002181 cytoplasmic translation 5/819 100/18670 0.4481 0.6214 0.4765 EIF3I/MTOR/DRG2/EIF2S2/NCK1 5 BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5/819 100/18670 0.4481 0.6214 0.4765 IL18R1/IL12A/RSAD2/SOCS5/HLX 5 BP GO:0022600 digestive system process 5/819 100/18670 0.4481 0.6214 0.4765 VDR/HIP1R/NR1H3/KCNN4/EZR 5 BP GO:0001910 regulation of leukocyte mediated cytotoxicity 4/819 78/18670 0.4486 0.6214 0.4765 MICB/IL12A/ARRB2/DNASE1L3 4 BP GO:0030433 ubiquitin-dependent ERAD pathway 4/819 78/18670 0.4486 0.6214 0.4765 SEL1L/HSPA5/TRIM25/UBE2J1 4 BP GO:0072028 nephron morphogenesis 4/819 78/18670 0.4486 0.6214 0.4765 MAGED1/BMP4/WNT11/BCL2 4 BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 4/819 78/18670 0.4486 0.6214 0.4765 NUPR1/PTTG1IP/BCL2/PDK2 4 BP GO:2000300 regulation of synaptic vesicle exocytosis 4/819 78/18670 0.4486 0.6214 0.4765 ATP2A2/NAPA/PRKCB/UNC13B 4 BP GO:0000819 sister chromatid segregation 9/819 189/18670 0.4491 0.6218 0.4769 ESPL1/POGZ/SMC5/RRS1/CHMP2A/PPP2R1A/ANAPC15/KIF2C/IK 9 BP GO:1903008 organelle disassembly 5/819 101/18670 0.4567 0.629 0.4824 ATG2A/HAX1/HIF1A/CLEC16A/MAP1LC3B 5 BP GO:0001906 cell killing 8/819 168/18670 0.4576 0.629 0.4824 CD55/CTSC/MICB/IL12A/LYST/ARRB2/DNASE1L3/BAD 8 BP GO:0000266 mitochondrial fission 2/819 35/18670 0.4581 0.629 0.4824 MX1/MX2 2 BP GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2/819 35/18670 0.4581 0.629 0.4824 RRS1/BYSL 2 BP GO:0001881 receptor recycling 2/819 35/18670 0.4581 0.629 0.4824 RAB29/VAMP3 2 BP GO:0003230 cardiac atrium development 2/819 35/18670 0.4581 0.629 0.4824 TGFB2/SOX4 2 BP GO:0019433 triglyceride catabolic process 2/819 35/18670 0.4581 0.629 0.4824 ABHD5/PNPLA2 2 BP GO:0032801 receptor catabolic process 2/819 35/18670 0.4581 0.629 0.4824 AP2B1/VLDLR 2 BP GO:0034142 toll-like receptor 4 signaling pathway 2/819 35/18670 0.4581 0.629 0.4824 ITGB2/NR1H3 2 BP GO:0060251 regulation of glial cell proliferation 2/819 35/18670 0.4581 0.629 0.4824 IDH2/MTOR 2 BP GO:0070873 regulation of glycogen metabolic process 2/819 35/18670 0.4581 0.629 0.4824 ENPP1/MTOR 2 BP GO:0071312 cellular response to alkaloid 2/819 35/18670 0.4581 0.629 0.4824 ADCY8/BCL2L1 2 BP GO:0098801 regulation of renal system process 2/819 35/18670 0.4581 0.629 0.4824 GJA1/GAS6 2 BP GO:1904031 positive regulation of cyclin-dependent protein kinase activity 2/819 35/18670 0.4581 0.629 0.4824 CCND2/MAPRE3 2 BP GO:2000785 regulation of autophagosome assembly 2/819 35/18670 0.4581 0.629 0.4824 NUPR1/PIKFYVE 2 BP GO:0006446 regulation of translational initiation 4/819 79/18670 0.4584 0.629 0.4824 HABP4/MTOR/RPS6KB2/NCK1 4 BP GO:0030193 regulation of blood coagulation 4/819 79/18670 0.4584 0.629 0.4824 THBS1/PRKCA/FAP/PDGFA 4 BP GO:0055072 iron ion homeostasis 4/819 79/18670 0.4584 0.629 0.4824 ATP6V0D1/HIF1A/EPAS1/NEDD8 4 BP GO:0010665 regulation of cardiac muscle cell apoptotic process 3/819 57/18670 0.4594 0.629 0.4824 NUPR1/MAP3K5/JAK2 3 BP GO:0010965 regulation of mitotic sister chromatid separation 3/819 57/18670 0.4594 0.629 0.4824 ESPL1/ANAPC15/IK 3 BP GO:0019320 hexose catabolic process 3/819 57/18670 0.4594 0.629 0.4824 BAD/PGM1/TPI1 3 BP GO:0045981 positive regulation of nucleotide metabolic process 3/819 57/18670 0.4594 0.629 0.4824 NUPR1/HIF1A/STAT3 3 BP GO:0050819 negative regulation of coagulation 3/819 57/18670 0.4594 0.629 0.4824 THBS1/FAP/PDGFA 3 BP GO:0051310 metaphase plate congression 3/819 57/18670 0.4594 0.629 0.4824 RRS1/CHMP2A/KIF2C 3 BP GO:1900544 positive regulation of purine nucleotide metabolic process 3/819 57/18670 0.4594 0.629 0.4824 NUPR1/HIF1A/STAT3 3 BP GO:2000272 negative regulation of signaling receptor activity 3/819 57/18670 0.4594 0.629 0.4824 EPHB2/SOCS5/TSG101 3 BP GO:0002224 toll-like receptor signaling pathway 7/819 146/18670 0.4601 0.629 0.4824 MAPKAPK3/ITGB2/NR1H3/PIK3C3/ARRB2/RSAD2/IRF7 7 BP GO:2000241 regulation of reproductive process 7/819 146/18670 0.4601 0.629 0.4824 BMP4/NUPR1/CIB1/INHBB/SULF1/PLCB1/PPP2R1A 7 BP GO:2001251 negative regulation of chromosome organization 7/819 146/18670 0.4601 0.629 0.4824 ESPL1/PHF2/TERF2/ASF1A/ANAPC15/IK/HMGA1 7 BP GO:0007098 centrosome cycle 6/819 124/18670 0.4626 0.629 0.4824 HAUS7/NSFL1C/KAT2B/ARL2/CHMP2A/CKAP5 6 BP GO:0007269 neurotransmitter secretion 8/819 169/18670 0.4643 0.629 0.4824 ATP2A2/PPFIA4/SV2A/NAPA/PRKCB/UNC13B/NAAA/ASIC1 8 BP GO:0018394 peptidyl-lysine acetylation 8/819 169/18670 0.4643 0.629 0.4824 MAPK3/KAT2B/POLE3/SNAI2/WBP2/JADE2/SOX4/CREBBP 8 BP GO:0035335 peptidyl-tyrosine dephosphorylation 5/819 102/18670 0.4653 0.629 0.4824 PTPRA/PTPRK/DUSP7/PTPN11/PTPRB 5 BP GO:0002523 leukocyte migration involved in inflammatory response 1/819 14/18670 0.4665 0.629 0.4824 ITGB2 1 BP GO:0002834 regulation of response to tumor cell 1/819 14/18670 0.4665 0.629 0.4824 IL12A 1 BP GO:0002837 regulation of immune response to tumor cell 1/819 14/18670 0.4665 0.629 0.4824 IL12A 1 BP GO:0003128 heart field specification 1/819 14/18670 0.4665 0.629 0.4824 BMP4 1 BP GO:0006244 pyrimidine nucleotide catabolic process 1/819 14/18670 0.4665 0.629 0.4824 MBD4 1 BP GO:0006268 DNA unwinding involved in DNA replication 1/819 14/18670 0.4665 0.629 0.4824 HMGA1 1 BP GO:0006684 sphingomyelin metabolic process 1/819 14/18670 0.4665 0.629 0.4824 CLN3 1 BP GO:0006896 Golgi to vacuole transport 1/819 14/18670 0.4665 0.629 0.4824 GOSR2 1 BP GO:0007100 mitotic centrosome separation 1/819 14/18670 0.4665 0.629 0.4824 NSFL1C 1 BP GO:0009214 cyclic nucleotide catabolic process 1/819 14/18670 0.4665 0.629 0.4824 PDE4B 1 BP GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 1/819 14/18670 0.4665 0.629 0.4824 ATP1B1 1 BP GO:0010755 regulation of plasminogen activation 1/819 14/18670 0.4665 0.629 0.4824 THBS1 1 BP GO:0010917 negative regulation of mitochondrial membrane potential 1/819 14/18670 0.4665 0.629 0.4824 HEBP2 1 BP GO:0010935 regulation of macrophage cytokine production 1/819 14/18670 0.4665 0.629 0.4824 TGFB2 1 BP GO:0015780 nucleotide-sugar transmembrane transport 1/819 14/18670 0.4665 0.629 0.4824 SLC35D2 1 BP GO:0018410 C-terminal protein amino acid modification 1/819 14/18670 0.4665 0.629 0.4824 ICMT 1 BP GO:0021535 cell migration in hindbrain 1/819 14/18670 0.4665 0.629 0.4824 ITGB1 1 BP GO:0031272 regulation of pseudopodium assembly 1/819 14/18670 0.4665 0.629 0.4824 CDC42EP1 1 BP GO:0032310 prostaglandin secretion 1/819 14/18670 0.4665 0.629 0.4824 ABCC4 1 BP GO:0032785 negative regulation of DNA-templated transcription, elongation 1/819 14/18670 0.4665 0.629 0.4824 SUPT4H1 1 BP GO:0034392 negative regulation of smooth muscle cell apoptotic process 1/819 14/18670 0.4665 0.629 0.4824 ARRB2 1 BP GO:0035112 genitalia morphogenesis 1/819 14/18670 0.4665 0.629 0.4824 ROR2 1 BP GO:0035435 phosphate ion transmembrane transport 1/819 14/18670 0.4665 0.629 0.4824 SLC20A1 1 BP GO:0035810 positive regulation of urine volume 1/819 14/18670 0.4665 0.629 0.4824 HAS2 1 BP GO:0036295 cellular response to increased oxygen levels 1/819 14/18670 0.4665 0.629 0.4824 ATP6V0D1 1 BP GO:0036376 sodium ion export across plasma membrane 1/819 14/18670 0.4665 0.629 0.4824 ATP1B1 1 BP GO:0040034 regulation of development, heterochronic 1/819 14/18670 0.4665 0.629 0.4824 HMGN1 1 BP GO:0043144 snoRNA processing 1/819 14/18670 0.4665 0.629 0.4824 EXOSC2 1 BP GO:0043374 CD8-positive, alpha-beta T cell differentiation 1/819 14/18670 0.4665 0.629 0.4824 BCL2 1 BP GO:0043558 regulation of translational initiation in response to stress 1/819 14/18670 0.4665 0.629 0.4824 NCK1 1 BP GO:0044090 positive regulation of vacuole organization 1/819 14/18670 0.4665 0.629 0.4824 GRN 1 BP GO:0045346 regulation of MHC class II biosynthetic process 1/819 14/18670 0.4665 0.629 0.4824 JAK2 1 BP GO:0045836 positive regulation of meiotic nuclear division 1/819 14/18670 0.4665 0.629 0.4824 PLCB1 1 BP GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 1/819 14/18670 0.4665 0.629 0.4824 APOBEC3C 1 BP GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 1/819 14/18670 0.4665 0.629 0.4824 ARRB2 1 BP GO:0046033 AMP metabolic process 1/819 14/18670 0.4665 0.629 0.4824 AK1 1 BP GO:0046037 GMP metabolic process 1/819 14/18670 0.4665 0.629 0.4824 GUK1 1 BP GO:0046479 glycosphingolipid catabolic process 1/819 14/18670 0.4665 0.629 0.4824 GM2A 1 BP GO:0046629 gamma-delta T cell activation 1/819 14/18670 0.4665 0.629 0.4824 MICB 1 BP GO:0046940 nucleoside monophosphate phosphorylation 1/819 14/18670 0.4665 0.629 0.4824 AK1 1 BP GO:0048308 organelle inheritance 1/819 14/18670 0.4665 0.629 0.4824 MAPK3 1 BP GO:0048313 Golgi inheritance 1/819 14/18670 0.4665 0.629 0.4824 MAPK3 1 BP GO:0050720 interleukin-1 beta biosynthetic process 1/819 14/18670 0.4665 0.629 0.4824 JAK2 1 BP GO:0051712 positive regulation of killing of cells of other organism 1/819 14/18670 0.4665 0.629 0.4824 BAD 1 BP GO:0051775 response to redox state 1/819 14/18670 0.4665 0.629 0.4824 ARNTL 1 BP GO:0051938 L-glutamate import 1/819 14/18670 0.4665 0.629 0.4824 PER2 1 BP GO:0055064 chloride ion homeostasis 1/819 14/18670 0.4665 0.629 0.4824 CKB 1 BP GO:0060452 positive regulation of cardiac muscle contraction 1/819 14/18670 0.4665 0.629 0.4824 RGS2 1 BP GO:0070307 lens fiber cell development 1/819 14/18670 0.4665 0.629 0.4824 TMOD1 1 BP GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 1/819 14/18670 0.4665 0.629 0.4824 MTOR 1 BP GO:0071391 cellular response to estrogen stimulus 1/819 14/18670 0.4665 0.629 0.4824 WBP2 1 BP GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus 1/819 14/18670 0.4665 0.629 0.4824 RRS1 1 BP GO:0072216 positive regulation of metanephros development 1/819 14/18670 0.4665 0.629 0.4824 PDGFA 1 BP GO:0080009 mRNA methylation 1/819 14/18670 0.4665 0.629 0.4824 CMTR1 1 BP GO:0090069 regulation of ribosome biogenesis 1/819 14/18670 0.4665 0.629 0.4824 WDR43 1 BP GO:0090128 regulation of synapse maturation 1/819 14/18670 0.4665 0.629 0.4824 ARHGEF15 1 BP GO:0090231 regulation of spindle checkpoint 1/819 14/18670 0.4665 0.629 0.4824 ANAPC15 1 BP GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 1/819 14/18670 0.4665 0.629 0.4824 ANAPC15 1 BP GO:0099171 presynaptic modulation of chemical synaptic transmission 1/819 14/18670 0.4665 0.629 0.4824 PRKCB 1 BP GO:0106057 negative regulation of calcineurin-mediated signaling 1/819 14/18670 0.4665 0.629 0.4824 MTOR 1 BP GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1/819 14/18670 0.4665 0.629 0.4824 PRKCA 1 BP GO:1900121 negative regulation of receptor binding 1/819 14/18670 0.4665 0.629 0.4824 ADAM15 1 BP GO:1900452 regulation of long-term synaptic depression 1/819 14/18670 0.4665 0.629 0.4824 ADCY8 1 BP GO:1901386 negative regulation of voltage-gated calcium channel activity 1/819 14/18670 0.4665 0.629 0.4824 GNB5 1 BP GO:1901722 regulation of cell proliferation involved in kidney development 1/819 14/18670 0.4665 0.629 0.4824 BMP4 1 BP GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 1/819 14/18670 0.4665 0.629 0.4824 THBS1 1 BP GO:1903351 cellular response to dopamine 1/819 14/18670 0.4665 0.629 0.4824 MAPK3 1 BP GO:1903504 regulation of mitotic spindle checkpoint 1/819 14/18670 0.4665 0.629 0.4824 ANAPC15 1 BP GO:1904152 regulation of retrograde protein transport, ER to cytosol 1/819 14/18670 0.4665 0.629 0.4824 UBE2J1 1 BP GO:1904814 regulation of protein localization to chromosome, telomeric region 1/819 14/18670 0.4665 0.629 0.4824 CCT7 1 BP GO:1904889 regulation of excitatory synapse assembly 1/819 14/18670 0.4665 0.629 0.4824 IL1RAP 1 BP GO:1905516 positive regulation of fertilization 1/819 14/18670 0.4665 0.629 0.4824 PLCB1 1 BP GO:2001212 regulation of vasculogenesis 1/819 14/18670 0.4665 0.629 0.4824 RAMP2 1 BP GO:0010212 response to ionizing radiation 7/819 147/18670 0.4672 0.6296 0.4829 CRYAB/HSPA5/BCL2L1/POLE3/SNAI2/XRCC6/BCL2 7 BP GO:1901657 glycosyl compound metabolic process 7/819 147/18670 0.4672 0.6296 0.4829 NME3/APOBEC3B/PRPSAP2/TK2/GUK1/APOBEC3C/CTPS1 7 BP GO:0033045 regulation of sister chromatid segregation 4/819 80/18670 0.4681 0.6305 0.4835 ESPL1/SMC5/ANAPC15/IK 4 BP GO:0070509 calcium ion import 4/819 80/18670 0.4681 0.6305 0.4835 CXCL12/ATP2A2/CAV3/CACNA1C 4 BP GO:0032722 positive regulation of chemokine production 3/819 58/18670 0.4708 0.6334 0.4858 POSTN/HIF1A/IL4R 3 BP GO:0046605 regulation of centrosome cycle 3/819 58/18670 0.4708 0.6334 0.4858 NSFL1C/KAT2B/CHMP2A 3 BP GO:0071385 cellular response to glucocorticoid stimulus 3/819 58/18670 0.4708 0.6334 0.4858 ZFP36/CASP9/FOXO3 3 BP GO:0008037 cell recognition 10/819 215/18670 0.4708 0.6334 0.4858 EPHB2/GAP43/FOLR3/FOLR2/PALLD/NRP1/SPA17/IGLL1/CCT7/VCAN 10 BP GO:0019935 cyclic-nucleotide-mediated signaling 10/819 215/18670 0.4708 0.6334 0.4858 THBS1/PRKCA/ADCY8/RAMP2/RUNDC3A/ADCY7/DEFB1/RGS2/LPAR1/HTR2B 10 BP GO:0099643 signal release from synapse 8/819 170/18670 0.4709 0.6334 0.4858 ATP2A2/PPFIA4/SV2A/NAPA/PRKCB/UNC13B/NAAA/ASIC1 8 BP GO:0000154 rRNA modification 2/819 36/18670 0.4727 0.6344 0.4866 THUMPD1/NHP2 2 BP GO:0000578 embryonic axis specification 2/819 36/18670 0.4727 0.6344 0.4866 KDM6A/TMED2 2 BP GO:0006007 glucose catabolic process 2/819 36/18670 0.4727 0.6344 0.4866 BAD/TPI1 2 BP GO:0010453 regulation of cell fate commitment 2/819 36/18670 0.4727 0.6344 0.4866 FZD7/BMP4 2 BP GO:0016180 snRNA processing 2/819 36/18670 0.4727 0.6344 0.4866 EXOSC7/EXOSC2 2 BP GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 2/819 36/18670 0.4727 0.6344 0.4866 THBS1/SULF1 2 BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 2/819 36/18670 0.4727 0.6344 0.4866 ANAPC15/IK 2 BP GO:1902622 regulation of neutrophil migration 2/819 36/18670 0.4727 0.6344 0.4866 THBS4/BST1 2 BP GO:2001171 positive regulation of ATP biosynthetic process 2/819 36/18670 0.4727 0.6344 0.4866 HIF1A/STAT3 2 BP GO:0051983 regulation of chromosome segregation 5/819 103/18670 0.4738 0.6356 0.4874 ESPL1/SMC5/ANAPC15/KIF2C/IK 5 BP GO:1902106 negative regulation of leukocyte differentiation 5/819 103/18670 0.4738 0.6356 0.4874 BMP4/PIK3R1/SOCS5/IL4R/HLX 5 BP GO:0007031 peroxisome organization 4/819 81/18670 0.4777 0.6406 0.4913 HMGCL/MPV17/PEX7/CAT 4 BP GO:0031348 negative regulation of defense response 11/819 239/18670 0.479 0.6419 0.4923 MICB/GRN/ADCY7/ADAR/NR1H2/NR1H3/ABR/ARRB2/KLF4/SOCS5/SOCS3 11 BP GO:0015850 organic hydroxy compound transport 12/819 262/18670 0.4811 0.6419 0.4923 KDM5B/GRAMD1B/CXCL12/ABCG1/NR1H2/NR1H3/PLTP/ITGB3/GPM6B/MFSD10/PTPN11/TMF1 12 BP GO:0050773 regulation of dendrite development 7/819 149/18670 0.4814 0.6419 0.4923 IQGAP1/LPAR1/MTOR/CAMSAP2/TRPC6/VLDLR/CAMK1 7 BP GO:0001658 branching involved in ureteric bud morphogenesis 3/819 59/18670 0.4821 0.6419 0.4923 MAGED1/BMP4/BCL2 3 BP GO:0001885 endothelial cell development 3/819 59/18670 0.4821 0.6419 0.4923 MET/RAPGEF1/EZR 3 BP GO:0010656 negative regulation of muscle cell apoptotic process 3/819 59/18670 0.4821 0.6419 0.4923 NUPR1/ARRB2/JAK2 3 BP GO:0010662 regulation of striated muscle cell apoptotic process 3/819 59/18670 0.4821 0.6419 0.4923 NUPR1/MAP3K5/JAK2 3 BP GO:0033619 membrane protein proteolysis 3/819 59/18670 0.4821 0.6419 0.4923 MYH9/ADAM19/MBTPS1 3 BP GO:1902369 negative regulation of RNA catabolic process 3/819 59/18670 0.4821 0.6419 0.4923 HNRNPA0/ZFP36/MTOR 3 BP GO:0046928 regulation of neurotransmitter secretion 5/819 104/18670 0.4823 0.6419 0.4923 ATP2A2/NAPA/PRKCB/UNC13B/ASIC1 5 BP GO:0003156 regulation of animal organ formation 2/819 37/18670 0.4872 0.6419 0.4923 BMP4/SULF1 2 BP GO:0007099 centriole replication 2/819 37/18670 0.4872 0.6419 0.4923 KAT2B/CHMP2A 2 BP GO:0007339 binding of sperm to zona pellucida 2/819 37/18670 0.4872 0.6419 0.4923 SPA17/CCT7 2 BP GO:0010614 negative regulation of cardiac muscle hypertrophy 2/819 37/18670 0.4872 0.6419 0.4923 CAV3/RGS2 2 BP GO:0021587 cerebellum morphogenesis 2/819 37/18670 0.4872 0.6419 0.4923 HSPA5/PTPN11 2 BP GO:0030212 hyaluronan metabolic process 2/819 37/18670 0.4872 0.6419 0.4923 CEMIP/HAS2 2 BP GO:0042307 positive regulation of protein import into nucleus 2/819 37/18670 0.4872 0.6419 0.4923 PIK3R1/PIK3R2 2 BP GO:0043029 T cell homeostasis 2/819 37/18670 0.4872 0.6419 0.4923 BCL2/TCIRG1 2 BP GO:0046839 phospholipid dephosphorylation 2/819 37/18670 0.4872 0.6419 0.4923 SYNJ2/INPP5E 2 BP GO:0060323 head morphogenesis 2/819 37/18670 0.4872 0.6419 0.4923 COL1A1/PTPN11 2 BP GO:0071276 cellular response to cadmium ion 2/819 37/18670 0.4872 0.6419 0.4923 MAPK3/GSN 2 BP GO:0071542 dopaminergic neuron differentiation 2/819 37/18670 0.4872 0.6419 0.4923 HIF1A/FZD1 2 BP GO:0086010 membrane depolarization during action potential 2/819 37/18670 0.4872 0.6419 0.4923 CAV3/CACNA1C 2 BP GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2/819 37/18670 0.4872 0.6419 0.4923 CIB1/NRP1 2 BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 2/819 37/18670 0.4872 0.6419 0.4923 ANAPC15/IK 2 BP GO:2000403 positive regulation of lymphocyte migration 2/819 37/18670 0.4872 0.6419 0.4923 CXCL12/TNFRSF14 2 BP GO:0006855 drug transmembrane transport 4/819 82/18670 0.4873 0.6419 0.4923 FOLR2/SLC1A5/RGS2/PER2 4 BP GO:0016064 immunoglobulin mediated immune response 10/819 218/18670 0.4884 0.6419 0.4923 CD55/THOC1/C1S/IL13RA2/C1R/IL4R/IGLL1/HLA-DQB1/IRF7/TCIRG1 10 BP GO:0001325 formation of extrachromosomal circular DNA 1/819 15/18670 0.4899 0.6419 0.4923 TERF2 1 BP GO:0001829 trophectodermal cell differentiation 1/819 15/18670 0.4899 0.6419 0.4923 BYSL 1 BP GO:0002467 germinal center formation 1/819 15/18670 0.4899 0.6419 0.4923 PKN1 1 BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 1/819 15/18670 0.4899 0.6419 0.4923 TAP1 1 BP GO:0002716 negative regulation of natural killer cell mediated immunity 1/819 15/18670 0.4899 0.6419 0.4923 ARRB2 1 BP GO:0006646 phosphatidylethanolamine biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 PCYT2 1 BP GO:0007039 protein catabolic process in the vacuole 1/819 15/18670 0.4899 0.6419 0.4923 TCIRG1 1 BP GO:0007512 adult heart development 1/819 15/18670 0.4899 0.6419 0.4923 GJA1 1 BP GO:0010561 negative regulation of glycoprotein biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 ITM2B 1 BP GO:0014874 response to stimulus involved in regulation of muscle adaptation 1/819 15/18670 0.4899 0.6419 0.4923 SGCA 1 BP GO:0015802 basic amino acid transport 1/819 15/18670 0.4899 0.6419 0.4923 CLN3 1 BP GO:0015936 coenzyme A metabolic process 1/819 15/18670 0.4899 0.6419 0.4923 COASY 1 BP GO:0017014 protein nitrosylation 1/819 15/18670 0.4899 0.6419 0.4923 SNTA1 1 BP GO:0018119 peptidyl-cysteine S-nitrosylation 1/819 15/18670 0.4899 0.6419 0.4923 SNTA1 1 BP GO:0018216 peptidyl-arginine methylation 1/819 15/18670 0.4899 0.6419 0.4923 PRMT1 1 BP GO:0019471 4-hydroxyproline metabolic process 1/819 15/18670 0.4899 0.6419 0.4923 P4HA1 1 BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 1/819 15/18670 0.4899 0.6419 0.4923 TAP1 1 BP GO:0030238 male sex determination 1/819 15/18670 0.4899 0.6419 0.4923 MAP3K4 1 BP GO:0030852 regulation of granulocyte differentiation 1/819 15/18670 0.4899 0.6419 0.4923 HAX1 1 BP GO:0031054 pre-miRNA processing 1/819 15/18670 0.4899 0.6419 0.4923 ADAR 1 BP GO:0031573 intra-S DNA damage checkpoint 1/819 15/18670 0.4899 0.6419 0.4923 XPC 1 BP GO:0032105 negative regulation of response to extracellular stimulus 1/819 15/18670 0.4899 0.6419 0.4923 SNAI2 1 BP GO:0032108 negative regulation of response to nutrient levels 1/819 15/18670 0.4899 0.6419 0.4923 SNAI2 1 BP GO:0032239 regulation of nucleobase-containing compound transport 1/819 15/18670 0.4899 0.6419 0.4923 NUP153 1 BP GO:0032352 positive regulation of hormone metabolic process 1/819 15/18670 0.4899 0.6419 0.4923 HIF1A 1 BP GO:0032486 Rap protein signal transduction 1/819 15/18670 0.4899 0.6419 0.4923 RAPGEF1 1 BP GO:0032736 positive regulation of interleukin-13 production 1/819 15/18670 0.4899 0.6419 0.4923 IL1RAP 1 BP GO:0033008 positive regulation of mast cell activation involved in immune response 1/819 15/18670 0.4899 0.6419 0.4923 IL4R 1 BP GO:0034310 primary alcohol catabolic process 1/819 15/18670 0.4899 0.6419 0.4923 ALDH2 1 BP GO:0034380 high-density lipoprotein particle assembly 1/819 15/18670 0.4899 0.6419 0.4923 BMP1 1 BP GO:0034616 response to laminar fluid shear stress 1/819 15/18670 0.4899 0.6419 0.4923 KLF4 1 BP GO:0035635 entry of bacterium into host cell 1/819 15/18670 0.4899 0.6419 0.4923 MET 1 BP GO:0042074 cell migration involved in gastrulation 1/819 15/18670 0.4899 0.6419 0.4923 WNT11 1 BP GO:0042754 negative regulation of circadian rhythm 1/819 15/18670 0.4899 0.6419 0.4923 PER2 1 BP GO:0043101 purine-containing compound salvage 1/819 15/18670 0.4899 0.6419 0.4923 GMPR 1 BP GO:0043306 positive regulation of mast cell degranulation 1/819 15/18670 0.4899 0.6419 0.4923 IL4R 1 BP GO:0043584 nose development 1/819 15/18670 0.4899 0.6419 0.4923 ALDH1A3 1 BP GO:0043650 dicarboxylic acid biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 MTHFD1 1 BP GO:0045342 MHC class II biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 JAK2 1 BP GO:0045360 regulation of interleukin-1 biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 JAK2 1 BP GO:0045410 positive regulation of interleukin-6 biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 STAT3 1 BP GO:0045837 negative regulation of membrane potential 1/819 15/18670 0.4899 0.6419 0.4923 HEBP2 1 BP GO:0046184 aldehyde biosynthetic process 1/819 15/18670 0.4899 0.6419 0.4923 TPI1 1 BP GO:0048070 regulation of developmental pigmentation 1/819 15/18670 0.4899 0.6419 0.4923 BCL2 1 BP GO:0048172 regulation of short-term neuronal synaptic plasticity 1/819 15/18670 0.4899 0.6419 0.4923 UNC13B 1 BP GO:0051127 positive regulation of actin nucleation 1/819 15/18670 0.4899 0.6419 0.4923 GSN 1 BP GO:0051299 centrosome separation 1/819 15/18670 0.4899 0.6419 0.4923 NSFL1C 1 BP GO:0051883 killing of cells in other organism involved in symbiotic interaction 1/819 15/18670 0.4899 0.6419 0.4923 BAD 1 BP GO:0060099 regulation of phagocytosis, engulfment 1/819 15/18670 0.4899 0.6419 0.4923 ITGA2 1 BP GO:0060253 negative regulation of glial cell proliferation 1/819 15/18670 0.4899 0.6419 0.4923 IDH2 1 BP GO:0060339 negative regulation of type I interferon-mediated signaling pathway 1/819 15/18670 0.4899 0.6419 0.4923 ADAR 1 BP GO:0060766 negative regulation of androgen receptor signaling pathway 1/819 15/18670 0.4899 0.6419 0.4923 PHB 1 BP GO:0070365 hepatocyte differentiation 1/819 15/18670 0.4899 0.6419 0.4923 ITGA2 1 BP GO:0070571 negative regulation of neuron projection regeneration 1/819 15/18670 0.4899 0.6419 0.4923 THY1 1 BP GO:0071474 cellular hyperosmotic response 1/819 15/18670 0.4899 0.6419 0.4923 XRCC6 1 BP GO:0072148 epithelial cell fate commitment 1/819 15/18670 0.4899 0.6419 0.4923 NRP1 1 BP GO:0072283 metanephric renal vesicle morphogenesis 1/819 15/18670 0.4899 0.6419 0.4923 BMP4 1 BP GO:0090192 regulation of glomerulus development 1/819 15/18670 0.4899 0.6419 0.4923 BMP4 1 BP GO:0090656 t-circle formation 1/819 15/18670 0.4899 0.6419 0.4923 TERF2 1 BP GO:0090737 telomere maintenance via telomere trimming 1/819 15/18670 0.4899 0.6419 0.4923 TERF2 1 BP GO:1900119 positive regulation of execution phase of apoptosis 1/819 15/18670 0.4899 0.6419 0.4923 FAP 1 BP GO:1901841 regulation of high voltage-gated calcium channel activity 1/819 15/18670 0.4899 0.6419 0.4923 PDE4B 1 BP GO:1902187 negative regulation of viral release from host cell 1/819 15/18670 0.4899 0.6419 0.4923 TRIM25 1 BP GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 1/819 15/18670 0.4899 0.6419 0.4923 BIN1 1 BP GO:1903350 response to dopamine 1/819 15/18670 0.4899 0.6419 0.4923 MAPK3 1 BP GO:1905874 regulation of postsynaptic density organization 1/819 15/18670 0.4899 0.6419 0.4923 IL1RAP 1 BP GO:2001256 regulation of store-operated calcium entry 1/819 15/18670 0.4899 0.6419 0.4923 STC2 1 BP GO:0010659 cardiac muscle cell apoptotic process 3/819 60/18670 0.4934 0.6458 0.4953 NUPR1/MAP3K5/JAK2 3 BP GO:0043486 histone exchange 3/819 60/18670 0.4934 0.6458 0.4953 ITGB3BP/POLE3/ANP32E 3 BP GO:0045576 mast cell activation 3/819 60/18670 0.4934 0.6458 0.4953 S100A13/IL13RA2/IL4R 3 BP GO:0051784 negative regulation of nuclear division 3/819 60/18670 0.4934 0.6458 0.4953 BMP4/ANAPC15/IK 3 BP GO:0042113 B cell activation 14/819 310/18670 0.4945 0.6471 0.4963 THOC1/KLF6/PIK3R1/CD70/BST1/PRKCB/IGLL1/BAD/BCL2/TCIRG1/PAWR/PKN1/CTPS1/ITGB1 14 BP GO:0015849 organic acid transport 15/819 333/18670 0.4957 0.6484 0.4973 SLC35D2/CTNS/SLC7A8/THBS1/CLN3/FOLR3/PPFIA4/FOLR2/NTRK2/SV2A/SLC1A5/ABCC4/RGS2/UNC13B/PER2 15 BP GO:0046942 carboxylic acid transport 15/819 333/18670 0.4957 0.6484 0.4973 SLC35D2/CTNS/SLC7A8/THBS1/CLN3/FOLR3/PPFIA4/FOLR2/NTRK2/SV2A/SLC1A5/ABCC4/RGS2/UNC13B/PER2 15 BP GO:0008652 cellular amino acid biosynthetic process 4/819 83/18670 0.4968 0.6494 0.498 PYCR1/SERINC5/MTHFD1/BCAT2 4 BP GO:0045913 positive regulation of carbohydrate metabolic process 4/819 83/18670 0.4968 0.6494 0.498 KAT2B/HIF1A/HAS2/BAD 4 BP GO:0046470 phosphatidylcholine metabolic process 4/819 83/18670 0.4968 0.6494 0.498 PLA2G15/PLA2G4C/CDS1/ENPP2 4 CC GO:0062023 collagen-containing extracellular matrix 64/839 406/19717 7.346e-20 4.636e-17 3.464e-17 PRG4/COL8A1/BGN/COL5A2/COL3A1/GREM1/EDIL3/KAZALD1/COL16A1/RARRES2/IGFBP7/COL1A2/THBS4/CTSC/NID2/NID1/THBS1/MYOC/SPARC/LTBP1/MXRA5/COL11A1/CD151/PXDN/CXCL12/EMILIN1/POSTN/COL1A1/SERPINH1/SOD3/COMP/FMOD/LAMB1/MEGF9/ELN/COL14A1/TGM2/HSPG2/LTBP2/HAPLN1/FBN2/COL6A3/SPARCL1/GPC4/EFEMP1/COL7A1/COL15A1/LOXL2/COL4A1/SERPINB6/TGFB2/SULF1/ADAM19/LAMA1/ITGA6/SPON1/FBLN5/ADAMDEC1/TNC/ACAN/TGM4/COL4A2/VCAN/LMAN1 64 CC GO:0044420 extracellular matrix component 20/839 51/19717 6.752e-15 2.13e-12 1.592e-12 COL8A1/COL5A2/COL3A1/COL1A2/LTBP1/COL11A1/EMILIN1/COL1A1/LAMB1/ELN/COL14A1/FBN2/COL7A1/COL15A1/COL4A1/LAMA1/FBLN5/TNC/ACAN/COL4A2 20 CC GO:0005925 focal adhesion 50/839 405/19717 1.333e-11 2.759e-09 2.062e-09 MAPK3/ACTN1/CD151/PDLIM1/ITGA1/PTK7/GJA1/HSPA5/PALLD/TGM2/ITGB2/CDC42EP1/UBOX5/HSPG2/FZD2/MYH9/ATP6V0C/IQGAP1/CSRP2/FAP/NRP1/ITGB3/ITGA3/FLII/ARPC1B/GSN/PPIB/MRC2/ARL2/FLNB/SORBS3/CAV3/THY1/MPZL1/DDR2/JAK2/ITGA6/TNC/CNN1/ITGA2/PIP5K1A/FZD1/CAT/PDLIM7/SLC9A3R2/SDC4/HMGA1/EZR/ITGB1/SORBS2 50 CC GO:0005924 cell-substrate adherens junction 50/839 408/19717 1.749e-11 2.759e-09 2.062e-09 MAPK3/ACTN1/CD151/PDLIM1/ITGA1/PTK7/GJA1/HSPA5/PALLD/TGM2/ITGB2/CDC42EP1/UBOX5/HSPG2/FZD2/MYH9/ATP6V0C/IQGAP1/CSRP2/FAP/NRP1/ITGB3/ITGA3/FLII/ARPC1B/GSN/PPIB/MRC2/ARL2/FLNB/SORBS3/CAV3/THY1/MPZL1/DDR2/JAK2/ITGA6/TNC/CNN1/ITGA2/PIP5K1A/FZD1/CAT/PDLIM7/SLC9A3R2/SDC4/HMGA1/EZR/ITGB1/SORBS2 50 CC GO:0030055 cell-substrate junction 50/839 412/19717 2.5e-11 3.155e-09 2.358e-09 MAPK3/ACTN1/CD151/PDLIM1/ITGA1/PTK7/GJA1/HSPA5/PALLD/TGM2/ITGB2/CDC42EP1/UBOX5/HSPG2/FZD2/MYH9/ATP6V0C/IQGAP1/CSRP2/FAP/NRP1/ITGB3/ITGA3/FLII/ARPC1B/GSN/PPIB/MRC2/ARL2/FLNB/SORBS3/CAV3/THY1/MPZL1/DDR2/JAK2/ITGA6/TNC/CNN1/ITGA2/PIP5K1A/FZD1/CAT/PDLIM7/SLC9A3R2/SDC4/HMGA1/EZR/ITGB1/SORBS2 50 CC GO:0001726 ruffle 28/839 172/19717 9.652e-10 1.015e-07 7.586e-08 ACTN1/MTSS1/HIP1R/ARF4/PALLD/MYO10/CIB1/TPM1/MYH9/IQGAP1/FAP/MYO5A/DIAPH1/CD2AP/ITGB3/PODXL/GSN/FSCN1/EPS8/RASA1/ITGB1BP1/CLIP1/INPP5E/SH3YL1/PIP5K1A/PDLIM7/EZR/ITGB1 28 CC GO:0005788 endoplasmic reticulum lumen 37/839 309/19717 1.437e-08 1.295e-06 9.68e-07 COL8A1/COL5A2/COL3A1/COL16A1/IGFBP7/COL1A2/CTSC/STC2/THBS1/LTBP1/COL11A1/COL1A1/SERPINH1/BMP4/LAMB1/SCG2/IGFBP1/COL14A1/HSPA5/IL12A/FMO1/P4HA1/COL6A3/SPARCL1/PPIB/COL7A1/PDGFA/COL15A1/COL4A1/PNPLA2/GAS6/SPON1/TNC/MBTPS1/CALU/COL4A2/VCAN 37 CC GO:0098644 complex of collagen trimers 9/839 19/19717 2.757e-08 2.174e-06 1.625e-06 COL8A1/COL5A2/COL3A1/COL1A2/COL11A1/COL1A1/COL7A1/COL4A1/COL4A2 9 CC GO:0031252 cell leading edge 43/839 403/19717 3.109e-08 2.18e-06 1.629e-06 ACTN1/MTSS1/HIP1R/PLXND1/ARF4/MCC/PALLD/MYO10/DDN/CIB1/DPYSL3/TPM1/MYH9/IQGAP1/MYLK/FAP/MYO5A/HAX1/DIAPH1/CD2AP/ITGB3/PODXL/GSN/TWF2/PTPRK/FSCN1/EPS8/ABLIM1/THY1/PALM/RASA1/ITGB1BP1/CLIP1/INPP5E/SH3YL1/PIP5K1A/SPTBN1/ACTA2/PDLIM7/PHACTR4/EZR/ITGB1/SORBS2 43 CC GO:0005604 basement membrane 18/839 95/19717 8.851e-08 5.585e-06 4.174e-06 COL8A1/THBS4/NID2/NID1/SPARC/CD151/LAMB1/MEGF9/HSPG2/COL7A1/COL15A1/LOXL2/COL4A1/LAMA1/ITGA6/TNC/ACAN/COL4A2 18 CC GO:0005774 vacuolar membrane 40/839 412/19717 1.115e-06 6.02e-05 4.499e-05 ENPP1/PI4K2A/CTNS/ATP8A1/PRCP/FPR1/PLEKHM1/VPS41/CTSA/CLN3/ATP6V0A1/MMD/GRN/ATP6V0D1/ATP6V1E1/RRAGD/PRKD1/ATP11B/CLCN7/ATP6V0C/LAMTOR5/ATP6V1H/VPS11/CLEC16A/NAPA/SPG11/HLA-DRB4/SEC13/GLIPR1/MTOR/HLA-DQB1/TCIRG1/CLCN6/AP2B1/ATP6V1D/MAP1LC3B/ABCC10/UBA1/VLDLR/HLA-DPB1 40 CC GO:1990204 oxidoreductase complex 18/839 112/19717 1.145e-06 6.02e-05 4.499e-05 NDUFB8/SDHA/OGDH/NDUFAB1/P4HA1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/PDK1/SDHB/GPD1L/UQCRC1/RRM2/NDUFA1/NDUFB7/PDK2 18 CC GO:0005765 lysosomal membrane 36/839 354/19717 1.302e-06 6.27e-05 4.686e-05 ENPP1/PI4K2A/CTNS/ATP8A1/PRCP/FPR1/PLEKHM1/VPS41/CTSA/CLN3/ATP6V0A1/MMD/GRN/ATP6V0D1/ATP6V1E1/ATP11B/CLCN7/ATP6V0C/LAMTOR5/ATP6V1H/VPS11/CLEC16A/SPG11/HLA-DRB4/SEC13/GLIPR1/MTOR/HLA-DQB1/TCIRG1/CLCN6/AP2B1/ATP6V1D/ABCC10/UBA1/VLDLR/HLA-DPB1 36 CC GO:0098852 lytic vacuole membrane 36/839 355/19717 1.391e-06 6.27e-05 4.686e-05 ENPP1/PI4K2A/CTNS/ATP8A1/PRCP/FPR1/PLEKHM1/VPS41/CTSA/CLN3/ATP6V0A1/MMD/GRN/ATP6V0D1/ATP6V1E1/ATP11B/CLCN7/ATP6V0C/LAMTOR5/ATP6V1H/VPS11/CLEC16A/SPG11/HLA-DRB4/SEC13/GLIPR1/MTOR/HLA-DQB1/TCIRG1/CLCN6/AP2B1/ATP6V1D/ABCC10/UBA1/VLDLR/HLA-DPB1 36 CC GO:0030139 endocytic vesicle 32/839 303/19717 2.244e-06 9.44e-05 7.055e-05 ATP6V0E2/MTSS1/HIP1R/SPARC/CEMIP/ATP6V0A1/SH3GL2/CLTB/RAB32/ATP6V0D1/FZD2/ATP6V0C/PIK3C3/KIAA1107/VPS11/CD2AP/GSN/ANXA3/HLA-DRB4/FLNB/RAPGEF1/ARRB2/RAB8A/LPAR1/HLA-DQB1/UNC13B/ROR2/TCIRG1/AP2B1/TAP1/VAMP3/HLA-DPB1 32 CC GO:0098978 glutamatergic synapse 35/839 349/19717 2.505e-06 9.879e-05 7.383e-05 ACTN1/CDH11/SPARC/SH3GL2/PIN1/ADCY8/EPHB2/IL1RAP/TANC2/SV2A/ARF4/NPTX2/ABR/NRP1/MYO5A/SPARCL1/GPC4/ITGB3/NAPA/EPS8/STAT3/NPTX1/JAK2/RAB8A/MTOR/UNC13B/PLCB1/ACAN/AP2B1/PPP2R1A/SPTBN1/NRP2/GRIN2A/ITGB1/CAMK1 35 CC GO:0005581 collagen trimer 15/839 87/19717 3.606e-06 0.0001338 1e-04 COL8A1/COL5A2/COL3A1/COL16A1/COL1A2/COL11A1/EMILIN1/COL1A1/COL14A1/LOX/COL6A3/COL7A1/COL15A1/COL4A1/COL4A2 15 CC GO:0005884 actin filament 17/839 111/19717 4.455e-06 0.0001562 0.0001167 ACTN1/TPM2/PDLIM1/PALLD/DPYSL3/TPM1/IQGAP1/TMOD1/MYO5A/SMTN/CD2AP/TWF2/GNG12/PDLIM7/PAWR/EZR/LMOD1 17 CC GO:0030666 endocytic vesicle membrane 21/839 167/19717 8.842e-06 0.0002936 0.0002195 ATP6V0E2/HIP1R/ATP6V0A1/SH3GL2/RAB32/ATP6V0D1/FZD2/ATP6V0C/PIK3C3/KIAA1107/ANXA3/HLA-DRB4/RAPGEF1/RAB8A/HLA-DQB1/ROR2/TCIRG1/AP2B1/TAP1/VAMP3/HLA-DPB1 21 CC GO:0043202 lysosomal lumen 15/839 95/19717 1.102e-05 0.0003351 0.0002505 BGN/CTSA/NAGLU/FMOD/HSPG2/GM2A/IDS/GPC4/LIPA/ASAH1/NAAA/ACAN/VCAN/SDC4/NCAN 15 CC GO:0005759 mitochondrial matrix 41/839 469/19717 1.115e-05 0.0003351 0.0002505 PYCR1/IDH2/ECI1/NDUFB8/LARS2/OXCT1/PCCB/MTHFD2/ACO2/HMGCL/MRPL40/FDXR/OGDH/HAGH/TDRD7/BCL2L1/NDUFAB1/AUH/TK2/HADH/CYP27A1/ISCA1/NDUFA7/NDUFS3/TRAP1/NDUFS7/MRPL28/ARL2/PDK1/ETFB/MTERF1/ALDH2/COASY/FLAD1/PDK2/FOXO3/BTD/ALDH7A1/MDH2/POLRMT/BCAT2 41 CC GO:0033179 proton-transporting V-type ATPase, V0 domain 5/839 10/19717 2.906e-05 0.0008334 0.0006229 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V0C/TCIRG1 5 CC GO:0030175 filopodium 15/839 104/19717 3.338e-05 0.000873 0.0006524 GAP43/NPTX2/MYO10/CIB1/MYO5A/ITGB3/ITGA3/PODXL/TWF2/FSCN1/PALM/ITGA6/ACTA2/EZR/ITGB1 15 CC GO:0008305 integrin complex 8/839 31/19717 3.427e-05 0.000873 0.0006524 EMILIN1/ITGA1/ITGB2/ITGB3/ITGA3/ITGA6/ITGA2/ITGB1 8 CC GO:0045121 membrane raft 30/839 315/19717 3.459e-05 0.000873 0.0006524 MAPK3/PI4K2A/SYNJ2/CD55/CLN3/ADCY8/UNC5B/ITGA1/SERPINH1/ANGPT1/GJA1/TGFBR1/ITGB2/IQGAP1/LAMTOR5/PODXL/HAS2/GPM6B/CD24/CAV3/THY1/ATP1B1/SULF1/JAK2/SGCA/STOML1/SDC4/EZR/PIKFYVE/ITGB1 30 CC GO:0098857 membrane microdomain 30/839 316/19717 3.67e-05 0.0008908 0.0006657 MAPK3/PI4K2A/SYNJ2/CD55/CLN3/ADCY8/UNC5B/ITGA1/SERPINH1/ANGPT1/GJA1/TGFBR1/ITGB2/IQGAP1/LAMTOR5/PODXL/HAS2/GPM6B/CD24/CAV3/THY1/ATP1B1/SULF1/JAK2/SGCA/STOML1/SDC4/EZR/PIKFYVE/ITGB1 30 CC GO:0005775 vacuolar lumen 20/839 172/19717 4.521e-05 0.001057 0.0007897 BGN/CTSC/CTSA/NAGLU/GRN/FMOD/PSMD1/HSPG2/GM2A/IDS/GPC4/LIPA/VAT1/ASAH1/NAAA/ACAN/VCAN/HEBP2/SDC4/NCAN 20 CC GO:0005583 fibrillar collagen trimer 5/839 11/19717 5.14e-05 0.001118 0.0008359 COL5A2/COL3A1/COL1A2/COL11A1/COL1A1 5 CC GO:0098643 banded collagen fibril 5/839 11/19717 5.14e-05 0.001118 0.0008359 COL5A2/COL3A1/COL1A2/COL11A1/COL1A1 5 CC GO:0045334 clathrin-coated endocytic vesicle 11/839 63/19717 6.298e-05 0.001325 0.00099 HIP1R/CEMIP/SH3GL2/CLTB/FZD2/KIAA1107/HLA-DRB4/HLA-DQB1/ROR2/AP2B1/HLA-DPB1 11 CC GO:0098636 protein complex involved in cell adhesion 8/839 34/19717 7.042e-05 0.001433 0.001071 EMILIN1/ITGA1/ITGB2/ITGB3/ITGA3/ITGA6/ITGA2/ITGB1 8 CC GO:0098589 membrane region 30/839 328/19717 7.3e-05 0.001439 0.001076 MAPK3/PI4K2A/SYNJ2/CD55/CLN3/ADCY8/UNC5B/ITGA1/SERPINH1/ANGPT1/GJA1/TGFBR1/ITGB2/IQGAP1/LAMTOR5/PODXL/HAS2/GPM6B/CD24/CAV3/THY1/ATP1B1/SULF1/JAK2/SGCA/STOML1/SDC4/EZR/PIKFYVE/ITGB1 30 CC GO:0030027 lamellipodium 21/839 193/19717 7.838e-05 0.001443 0.001078 PLXND1/MCC/PALLD/MYO10/CIB1/DPYSL3/MYLK/FAP/HAX1/ITGB3/PODXL/GSN/TWF2/FSCN1/ABLIM1/ITGB1BP1/PIP5K1A/ACTA2/PHACTR4/ITGB1/SORBS2 21 CC GO:0033176 proton-transporting V-type ATPase complex 7/839 26/19717 7.966e-05 0.001443 0.001078 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 7 CC GO:0030669 clathrin-coated endocytic vesicle membrane 9/839 44/19717 8.119e-05 0.001443 0.001078 HIP1R/SH3GL2/FZD2/KIAA1107/HLA-DRB4/HLA-DQB1/ROR2/AP2B1/HLA-DPB1 9 CC GO:0030670 phagocytic vesicle membrane 12/839 76/19717 8.231e-05 0.001443 0.001078 ATP6V0E2/ATP6V0A1/RAB32/ATP6V0D1/ATP6V0C/PIK3C3/ANXA3/RAPGEF1/RAB8A/TCIRG1/TAP1/VAMP3 12 CC GO:0005746 mitochondrial respiratory chain 13/839 88/19717 8.56e-05 0.00146 0.001091 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/SDHB/UQCRC1/COX7A2/NDUFA1/NDUFB7 13 CC GO:0030662 coated vesicle membrane 20/839 182/19717 0.0001003 0.001666 0.001245 HIP1R/CEMIP/KDELR3/SH3GL2/CLTB/ADCY8/FZD2/KIAA1107/GOSR2/HLA-DRB4/ARFGAP2/SEC13/HLA-DQB1/ROR2/AP2B1/SEC23B/LMAN1/VAMP3/TMED2/HLA-DPB1 20 CC GO:0042470 melanosome 14/839 106/19717 0.0001596 0.002517 0.001881 CTNS/ATP6V0A1/RAB32/HSPA5/SLC1A5/RAB27B/MYRIP/MYO5A/TYR/ITGB3/PPIB/RAB29/CALU/ITGB1 14 CC GO:0048770 pigment granule 14/839 106/19717 0.0001596 0.002517 0.001881 CTNS/ATP6V0A1/RAB32/HSPA5/SLC1A5/RAB27B/MYRIP/MYO5A/TYR/ITGB3/PPIB/RAB29/CALU/ITGB1 14 CC GO:0043292 contractile fiber 23/839 234/19717 0.0001728 0.002659 0.001987 ACTN1/CRYAB/TPM2/PDLIM1/GJA1/HABP4/PALLD/KAT2B/TPM1/CSRP2/TMOD1/PDE4B/TWF2/FLNB/CAV3/CACNA1C/BIN1/SPTBN1/ACTA2/PDLIM7/SDC4/LMOD1/SORBS2 23 CC GO:0010008 endosome membrane 38/839 479/19717 0.0001807 0.002715 0.002029 ATP6V0E2/STAM/PLEKHB2/SCAMP3/PLEKHM1/VPS41/ATP6V0A1/MMD/FZD7/ATP6V0D1/NTRK2/RAB27B/ATP11B/ATP6V0C/LAMTOR5/RNF144A/ITM2B/VPS11/GOSR2/CLEC16A/FIG4/HLA-DRB4/SNX27/RAB8A/CHMP2A/HLA-DQB1/TSG101/IRF7/PLEKHM2/TCIRG1/CLCN6/AP2B1/STOML1/VPS45/PIKFYVE/UBA1/VAMP3/HLA-DPB1 38 CC GO:0005798 Golgi-associated vesicle 19/839 178/19717 0.0002169 0.003144 0.00235 CTSC/VPS41/KDELR3/CLTB/GJA1/RAB27B/ITM2B/GOSR2/TYR/COL7A1/HLA-DRB4/ARFGAP2/SEC13/RAB8A/HLA-DQB1/SEC23B/LMAN1/TMED2/HLA-DPB1 19 CC GO:0033267 axon part 32/839 382/19717 0.0002192 0.003144 0.00235 MYOC/TRAK2/RANGAP1/ATP6V0D1/GAP43/BLVRB/NTRK2/PALLD/NPTX2/RAB27B/CIB1/DPYSL3/IQGAP1/EXOC3/NRP1/FKBP4/MYO5A/HIF1A/ITGA3/TWF2/FSCN1/EPS8/THY1/CNGA3/TERF2/PRKCB/SIGMAR1/UNC13B/ITGA2/BIN1/SPTBN1/MAP1A 32 CC GO:0098803 respiratory chain complex 12/839 85/19717 0.0002461 0.003451 0.002579 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/SDHB/UQCRC1/NDUFA1/NDUFB7 12 CC GO:0030135 coated vesicle 26/839 289/19717 0.0002797 0.003836 0.002867 CTSC/HIP1R/VPS41/CEMIP/KDELR3/SH3GL2/CLTB/ADCY8/RAB27B/FZD2/KIAA1107/VPS11/GOSR2/COL7A1/HLA-DRB4/ARFGAP2/SEC13/RAB8A/HLA-DQB1/ROR2/AP2B1/SEC23B/LMAN1/VAMP3/TMED2/HLA-DPB1 26 CC GO:0070469 respiratory chain 13/839 100/19717 0.0003174 0.004261 0.003185 NDUFB8/SDHA/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/SDHB/UQCRC1/COX7A2/NDUFA1/NDUFB7 13 CC GO:0031256 leading edge membrane 18/839 170/19717 0.0003474 0.004567 0.003413 HIP1R/PLXND1/ARF4/DDN/CIB1/TPM1/FAP/DIAPH1/ITGB3/PTPRK/EPS8/THY1/PALM/SH3YL1/PIP5K1A/SPTBN1/EZR/ITGB1 18 CC GO:0101002 ficolin-1-rich granule 19/839 185/19717 0.0003554 0.004577 0.00342 CD55/PRCP/FPR1/PLEKHO2/ATP6V0A1/PSMB7/ITGB2/ATP6V0C/XRCC6/DIAPH1/GSN/SERPINB6/ASAH1/TCIRG1/CAT/PSMD3/PGM1/PSMD2/GMFG 19 CC GO:0043025 neuronal cell body 38/839 497/19717 0.0003749 0.004731 0.003536 PI4K2A/HIP1R/CRYAB/SIAH2/TRAK2/SH3GL2/ADCY8/ITGA1/EPHB2/SV2A/NPTX2/KCND3/MYO10/DDN/CIB1/NRP1/CKB/FKBP4/MYO5A/ITPR3/ANXA3/KCNN4/PTPRK/NDUFS7/FLNB/THY1/TGFB2/CNGA3/IL6ST/RAB8A/LPAR1/MTOR/ROR2/MAP2K4/CACNA1C/STRN3/MAP1A/AGFG1 38 CC GO:0005796 Golgi lumen 13/839 102/19717 0.0003862 0.004778 0.003571 BGN/PCSK5/SOD3/FMOD/HSPG2/DEFB1/GPC4/PDGFA/GAS6/ACAN/VCAN/SDC4/NCAN 13 CC GO:0071437 invadopodium 5/839 16/19717 0.0004068 0.004936 0.003689 FAP/ITGA3/FSCN1/EZR/ITGB1 5 CC GO:0042641 actomyosin 11/839 79/19717 0.0004984 0.005853 0.004374 ACTN1/PDLIM1/KAT2B/TPM1/MYH9/MYLK/MYO5A/FSCN1/FLNB/ABLIM1/PDLIM7 11 CC GO:0045335 phagocytic vesicle 15/839 132/19717 0.0005009 0.005853 0.004374 ATP6V0E2/ATP6V0A1/RAB32/ATP6V0D1/ATP6V0C/PIK3C3/GSN/ANXA3/FLNB/RAPGEF1/RAB8A/UNC13B/TCIRG1/TAP1/VAMP3 15 CC GO:0044449 contractile fiber part 21/839 221/19717 0.0005117 0.00587 0.004387 ACTN1/CRYAB/TPM2/PDLIM1/HABP4/PALLD/KAT2B/TPM1/CSRP2/TMOD1/PDE4B/FLNB/CAV3/CACNA1C/BIN1/SPTBN1/ACTA2/PDLIM7/SDC4/LMOD1/SORBS2 21 CC GO:0030427 site of polarized growth 18/839 176/19717 0.0005286 0.005957 0.004452 PI4K2A/TRAK2/GAP43/PALLD/NPTX2/CIB1/DPYSL3/IQGAP1/EXOC3/NRP1/FKBP4/MYO5A/ITGA3/TWF2/FSCN1/EPS8/THY1/SIGMAR1 18 CC GO:0030016 myofibril 21/839 224/19717 0.000611 0.006741 0.005038 ACTN1/CRYAB/TPM2/PDLIM1/HABP4/PALLD/KAT2B/TPM1/CSRP2/TMOD1/PDE4B/TWF2/FLNB/CAV3/CACNA1C/BIN1/SPTBN1/PDLIM7/SDC4/LMOD1/SORBS2 21 CC GO:0005770 late endosome 23/839 256/19717 0.0006255 0.006741 0.005038 MAPK3/SLC31A2/CTNS/VPS41/CLN3/MMD/GRN/GJA1/IL12A/RAB27B/PIK3C3/LAMTOR5/VPS11/GOSR2/MYO5A/CLEC16A/FIG4/HLA-DRB4/CHMP2A/TSG101/TCIRG1/STOML1/PIKFYVE 23 CC GO:0032587 ruffle membrane 12/839 94/19717 0.0006303 0.006741 0.005038 HIP1R/ARF4/CIB1/TPM1/FAP/DIAPH1/ITGB3/EPS8/SH3YL1/PIP5K1A/EZR/ITGB1 12 CC GO:0030133 transport vesicle 31/839 392/19717 0.0007253 0.007628 0.005701 BGN/CD55/CLN3/KDELR3/SH3GL2/CLTB/ATP6V0D1/SV2A/BCL2L1/RAB27B/DPYSL3/KIAA1107/MYRIP/GOSR2/PDE4B/HLA-DRB4/WDR7/NPTX1/SEC13/RAB8A/HLA-DQB1/UNC13B/BIN1/SEC23B/VPS45/TMEM187/LMAN1/GRIN2A/VAMP3/TMED2/HLA-DPB1 31 CC GO:0031527 filopodium membrane 5/839 18/19717 0.0007433 0.007688 0.005746 GAP43/MYO10/ITGB3/ITGA3/PALM 5 CC GO:0005942 phosphatidylinositol 3-kinase complex 6/839 27/19717 0.0008008 0.00815 0.006091 PIK3R1/PIK3C3/PIK3R2/PIK3CB/SOCS5/SOCS3 6 CC GO:0002116 semaphorin receptor complex 4/839 11/19717 0.000845 0.008464 0.006325 PLXND1/NRP1/PLXNC1/NRP2 4 CC GO:0043209 myelin sheath 8/839 49/19717 0.0009957 0.009657 0.007217 PLP1/ITPR3/SERINC5/GSN/TSPAN2/PMP22/BCL2/ITGB1 8 CC GO:0018995 host 10/839 73/19717 0.00101 0.009657 0.007217 PI4K2A/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/LMAN1/KPNA3 10 CC GO:0043657 host cell 10/839 73/19717 0.00101 0.009657 0.007217 PI4K2A/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/LMAN1/KPNA3 10 CC GO:0030426 growth cone 17/839 171/19717 0.001026 0.009661 0.00722 TRAK2/GAP43/PALLD/NPTX2/CIB1/DPYSL3/IQGAP1/EXOC3/NRP1/FKBP4/MYO5A/ITGA3/TWF2/FSCN1/EPS8/THY1/SIGMAR1 17 CC GO:0101003 ficolin-1-rich granule membrane 9/839 61/19717 0.001042 0.009668 0.007226 CD55/PRCP/FPR1/ATP6V0A1/ITGB2/ATP6V0C/DIAPH1/SERPINB6/TCIRG1 9 CC GO:0030660 Golgi-associated vesicle membrane 13/839 114/19717 0.001122 0.01001 0.007479 KDELR3/CLTB/GJA1/ITM2B/GOSR2/HLA-DRB4/ARFGAP2/SEC13/HLA-DQB1/SEC23B/LMAN1/TMED2/HLA-DPB1 13 CC GO:0005747 mitochondrial respiratory chain complex I 8/839 50/19717 0.001142 0.01001 0.007479 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 CC GO:0030964 NADH dehydrogenase complex 8/839 50/19717 0.001142 0.01001 0.007479 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 CC GO:0045271 respiratory chain complex I 8/839 50/19717 0.001142 0.01001 0.007479 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 CC GO:0030017 sarcomere 19/839 204/19717 0.001176 0.01006 0.007515 ACTN1/CRYAB/TPM2/PDLIM1/HABP4/PALLD/KAT2B/TPM1/CSRP2/TMOD1/PDE4B/FLNB/CAV3/CACNA1C/BIN1/SPTBN1/PDLIM7/LMOD1/SORBS2 19 CC GO:0005802 trans-Golgi network 21/839 236/19717 0.001194 0.01006 0.007515 PI4K2A/ATP8A1/PCSK5/CHST7/SCAMP3/CLN3/CLTB/POSTN/RAB32/GRN/PRKD1/ATP11B/HLA-DRB4/CHST2/ARFGAP2/RAB8A/HLA-DQB1/RAB29/COG4/VAMP3/HLA-DPB1 21 CC GO:1990752 microtubule end 6/839 29/19717 0.001195 0.01006 0.007515 MYO5A/MAPRE3/CLIP1/CAMSAP2/KIF2C/CKAP5 6 CC GO:0030665 clathrin-coated vesicle membrane 13/839 115/19717 0.001217 0.01011 0.007553 HIP1R/CEMIP/SH3GL2/CLTB/ADCY8/FZD2/KIAA1107/HLA-DRB4/HLA-DQB1/ROR2/AP2B1/VAMP3/HLA-DPB1 13 CC GO:0032432 actin filament bundle 10/839 75/19717 0.001249 0.01014 0.007576 ACTN1/CRYAB/PDLIM1/TPM1/MYH9/MYLK/FSCN1/FLNB/ABLIM1/PDLIM7 10 CC GO:0035371 microtubule plus-end 5/839 20/19717 0.001253 0.01014 0.007576 MYO5A/MAPRE3/CLIP1/KIF2C/CKAP5 5 CC GO:0016469 proton-transporting two-sector ATPase complex 8/839 51/19717 0.001305 0.01042 0.007788 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 CC GO:0098858 actin-based cell projection 19/839 208/19717 0.001477 0.01164 0.0087 GAP43/ANGPT1/ATP6V1E1/NPTX2/MYO10/CIB1/MYO5A/ITGB3/ITGA3/PODXL/TWF2/PDGFA/FSCN1/EPS8/PALM/ITGA6/ACTA2/EZR/ITGB1 19 CC GO:0044215 other organism 10/839 77/19717 0.001531 0.01164 0.0087 PI4K2A/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/LMAN1/KPNA3 10 CC GO:0044216 other organism cell 10/839 77/19717 0.001531 0.01164 0.0087 PI4K2A/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/LMAN1/KPNA3 10 CC GO:0044217 other organism part 10/839 77/19717 0.001531 0.01164 0.0087 PI4K2A/IFIT1/NUP205/NUP93/NUP153/SEC13/RAB29/TSG101/LMAN1/KPNA3 10 CC GO:0001725 stress fiber 9/839 67/19717 0.002049 0.01521 0.01137 ACTN1/PDLIM1/TPM1/MYH9/MYLK/FSCN1/FLNB/ABLIM1/PDLIM7 9 CC GO:0097517 contractile actin filament bundle 9/839 67/19717 0.002049 0.01521 0.01137 ACTN1/PDLIM1/TPM1/MYH9/MYLK/FSCN1/FLNB/ABLIM1/PDLIM7 9 CC GO:0030667 secretory granule membrane 24/839 298/19717 0.002171 0.01593 0.0119 CD55/ATP8A1/PRCP/FPR1/ABCA3/SPARC/ATP6V0A1/ITGB2/RAB27B/ATP11B/ATP6V0C/IQGAP1/EXOC3/ABCC4/DIAPH1/ITPR3/ITGB3/SERPINB6/BST1/GLIPR1/TCIRG1/ATP6V1D/PTPRB/TMED2 24 CC GO:0031968 organelle outer membrane 18/839 201/19717 0.002416 0.01735 0.01296 MYOC/RAB32/GJA1/AKAP1/TOMM34/BCL2L1/DNAJC11/HAX1/ITPR3/VAT1/RSAD2/MTOR/IFI27/SIGMAR1/BAD/BCL2/COASY/FOXO3 18 CC GO:0005911 cell-cell junction 33/839 459/19717 0.002423 0.01735 0.01296 ACTN1/CDH11/PNN/PDLIM1/ATP2A2/PTK7/GJA1/TGFBR1/CLDN4/PIK3R1/SV2A/GJC1/CDC42EP1/MYH9/IQGAP1/CD2AP/PODXL/PTPRK/FSCN1/CAV3/ATP1B1/PMP22/LAMA1/ITGA6/SGCA/CYTH1/KRT18/TRPC6/PDLIM7/PIKFYVE/UBA1/NCK1/ITGB1 33 CC GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 5/839 23/19717 0.002447 0.01735 0.01296 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V0C/TCIRG1 5 CC GO:0005905 clathrin-coated pit 9/839 69/19717 0.002518 0.01766 0.01319 HIP1R/CEMIP/CLTB/ADCY8/RAMP2/KIAA1107/ARRB2/AP2B1/VLDLR 9 CC GO:0150034 distal axon 23/839 285/19717 0.002587 0.01794 0.0134 TRAK2/ATP6V0D1/GAP43/BLVRB/NTRK2/PALLD/NPTX2/CIB1/DPYSL3/IQGAP1/EXOC3/NRP1/FKBP4/MYO5A/ITGA3/TWF2/FSCN1/EPS8/THY1/PRKCB/SIGMAR1/UNC13B/ITGA2 23 CC GO:0019867 outer membrane 18/839 203/19717 0.002691 0.01845 0.01379 MYOC/RAB32/GJA1/AKAP1/TOMM34/BCL2L1/DNAJC11/HAX1/ITPR3/VAT1/RSAD2/MTOR/IFI27/SIGMAR1/BAD/BCL2/COASY/FOXO3 18 CC GO:0034774 secretory granule lumen 25/839 321/19717 0.002784 0.01889 0.01412 ACTN1/RARRES2/CTSC/THBS1/SPARC/CTSA/PSMB7/GRN/FOLR3/VEGFC/PSMD1/GM2A/XRCC6/GSN/PDGFA/VAT1/TGFB2/GAS6/CHI3L1/PTX3/CAT/HEBP2/PSMD3/PSMD2/GMFG 25 CC GO:0030136 clathrin-coated vesicle 17/839 188/19717 0.002844 0.01909 0.01427 HIP1R/VPS41/CEMIP/SH3GL2/CLTB/ADCY8/RAB27B/FZD2/KIAA1107/VPS11/HLA-DRB4/RAB8A/HLA-DQB1/ROR2/AP2B1/VAMP3/HLA-DPB1 17 CC GO:0005741 mitochondrial outer membrane 16/839 178/19717 0.00395 0.02624 0.01961 MYOC/RAB32/GJA1/AKAP1/TOMM34/BCL2L1/DNAJC11/HAX1/VAT1/RSAD2/MTOR/IFI27/BAD/BCL2/COASY/FOXO3 16 CC GO:0012507 ER to Golgi transport vesicle membrane 8/839 62/19717 0.0046 0.03024 0.0226 GOSR2/HLA-DRB4/SEC13/HLA-DQB1/SEC23B/LMAN1/TMED2/HLA-DPB1 8 CC GO:0030176 integral component of endoplasmic reticulum membrane 14/839 150/19717 0.004869 0.03167 0.02367 TM7SF2/CLN3/ESYT1/RRBP1/ELOVL2/HSPA5/HLA-DRB4/ANKLE2/EXT1/HLA-DQB1/DPM2/TECR/TAP1/HLA-DPB1 14 CC GO:0005666 RNA polymerase III complex 4/839 17/19717 0.00497 0.03168 0.02368 POLR2L/POLR2E/POLR3D/POLR3G 4 CC GO:0016471 vacuolar proton-transporting V-type ATPase complex 4/839 17/19717 0.00497 0.03168 0.02368 ATP6V0A1/ATP6V0D1/ATP6V1H/TCIRG1 4 CC GO:0098800 inner mitochondrial membrane protein complex 13/839 135/19717 0.005031 0.03172 0.02371 NDUFB8/SDHA/NDUFAB1/DNAJC11/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/SDHB/UQCRC1/NDUFA1/NDUFB7 13 CC GO:0000502 proteasome complex 8/839 63/19717 0.005077 0.03172 0.02371 PSMD8/PSMB7/RAD23A/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 8 CC GO:0042383 sarcolemma 13/839 136/19717 0.005353 0.03309 0.02473 BGN/KCND3/CIB1/SNTA1/COL6A3/CAV3/ATP1B1/STAC/SGCA/CACNA1C/BIN1/EZR/ITGB1 13 CC GO:0060205 cytoplasmic vesicle lumen 25/839 338/19717 0.005401 0.03309 0.02473 ACTN1/RARRES2/CTSC/THBS1/SPARC/CTSA/PSMB7/GRN/FOLR3/VEGFC/PSMD1/GM2A/XRCC6/GSN/PDGFA/VAT1/TGFB2/GAS6/CHI3L1/PTX3/CAT/HEBP2/PSMD3/PSMD2/GMFG 25 CC GO:0045178 basal part of cell 7/839 51/19717 0.005576 0.03336 0.02493 PRCP/ITGA1/CLDN4/FAP/MET/ITGA6/ITGA2 7 CC GO:1905369 endopeptidase complex 8/839 64/19717 0.005592 0.03336 0.02493 PSMD8/PSMB7/RAD23A/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 8 CC GO:0031983 vesicle lumen 25/839 339/19717 0.005604 0.03336 0.02493 ACTN1/RARRES2/CTSC/THBS1/SPARC/CTSA/PSMB7/GRN/FOLR3/VEGFC/PSMD1/GM2A/XRCC6/GSN/PDGFA/VAT1/TGFB2/GAS6/CHI3L1/PTX3/CAT/HEBP2/PSMD3/PSMD2/GMFG 25 CC GO:0030134 COPII-coated ER to Golgi transport vesicle 10/839 93/19717 0.00615 0.03627 0.0271 CTSC/GOSR2/COL7A1/HLA-DRB4/SEC13/HLA-DQB1/SEC23B/LMAN1/TMED2/HLA-DPB1 10 CC GO:0098793 presynapse 33/839 491/19717 0.006705 0.03918 0.02928 PI4K2A/SYNJ2/CLN3/SH3GL2/CLTB/ADCY8/EPHB2/ATP6V0D1/PPFIA4/BLVRB/NTRK2/SV2A/BCL2L1/RAB27B/KIAA1107/EXOC3/PDE4B/GNB5/SLC29A1/GPC4/NAPA/GABBR1/WDR7/PRKCB/RAB8A/UNC13B/NAAA/ITGA2/BIN1/PNISR/VPS45/GRIN2A/VAMP3 33 CC GO:0005743 mitochondrial inner membrane 32/839 473/19717 0.006848 0.03964 0.02963 NDUFB8/MYOC/SDHA/MRPL40/FDXR/NDUFAF3/BCL2L1/NDUFAB1/DNAJC11/NDUFS6/SLC25A16/CYP27A1/NDUFA7/NDUFS3/CDS2/TRAP1/MPV17/NDUFS7/MRPL28/COX5B/UQCRQ/STAT3/UCP2/SDHB/RSAD2/UQCRC1/CKMT2/COX7A2/NDUFA1/COQ9/NDUFB7/PHB 32 CC GO:0031253 cell projection membrane 25/839 345/19717 0.006957 0.03991 0.02983 HIP1R/CLTB/GAP43/PLXND1/ARF4/MYO10/DDN/CIB1/TPM1/FAP/DIAPH1/ITGB3/ITGA3/PODXL/FSCN1/EPS8/THY1/PALM/IQCE/SH3YL1/PIP5K1A/SPTBN1/MFSD10/EZR/ITGB1 25 CC GO:0097470 ribbon synapse 3/839 10/19717 0.00736 0.04184 0.03127 SH3GL2/ATP2A2/UNC13B 3 CC GO:0070382 exocytic vesicle 17/839 207/19717 0.007454 0.042 0.03139 CLN3/SH3GL2/CLTB/ATP6V0D1/SV2A/BCL2L1/RAB27B/DPYSL3/KIAA1107/PDE4B/WDR7/RAB8A/UNC13B/BIN1/VPS45/GRIN2A/VAMP3 17 CC GO:0031362 anchored component of external side of plasma membrane 4/839 19/19717 0.007566 0.04225 0.03157 FOLR3/FOLR2/CD24/THY1 4 CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 14/839 158/19717 0.007642 0.0423 0.03161 TM7SF2/CLN3/ESYT1/RRBP1/ELOVL2/HSPA5/HLA-DRB4/ANKLE2/EXT1/HLA-DQB1/DPM2/TECR/TAP1/HLA-DPB1 14 CC GO:0008021 synaptic vesicle 16/839 191/19717 0.007718 0.04235 0.03165 CLN3/SH3GL2/CLTB/ATP6V0D1/SV2A/BCL2L1/RAB27B/KIAA1107/PDE4B/WDR7/RAB8A/UNC13B/BIN1/VPS45/GRIN2A/VAMP3 16 CC GO:0031674 I band 13/839 143/19717 0.008091 0.04401 0.03289 ACTN1/CRYAB/PDLIM1/PALLD/KAT2B/CSRP2/PDE4B/FLNB/CAV3/CACNA1C/BIN1/PDLIM7/SORBS2 13 CC GO:0005769 early endosome 25/839 350/19717 0.008281 0.04466 0.03338 MAPK3/STAM/SIAH2/VPS41/TRAK2/CLN3/SH3GL2/RAB32/ATP6V0D1/GJA1/NTRK2/ATP11B/TM9SF4/NRP1/VPS11/MYO5A/FIG4/SNX27/RAPGEF1/USP10/RAB29/TSG101/RABGAP1L/PHB/PIKFYVE 25 CC GO:0030132 clathrin coat of coated pit 4/839 20/19717 0.009144 0.0489 0.03654 HIP1R/CLTB/KIAA1107/AP2B1 4 CC GO:0005903 brush border 10/839 99/19717 0.009458 0.05015 0.03748 ACTN1/CLIC1/MYH9/CAPZA2/ITPR3/FLII/EPS8/FLNB/MFSD10/EZR 10 CC GO:0017146 NMDA selective glutamate receptor complex 3/839 11/19717 0.009802 0.05112 0.0382 EPS8/GRIN2B/GRIN2A 3 CC GO:0019774 proteasome core complex, beta-subunit complex 3/839 11/19717 0.009802 0.05112 0.0382 PSMB7/PSMB6/PSMB8 3 CC GO:0009897 external side of plasma membrane 27/839 393/19717 0.01019 0.05271 0.03939 CRLF1/THBS1/CXCL12/CCRL2/ABCG1/ITGA1/MICB/FOLR3/FOLR2/ITGB2/TNFRSF14/GHR/SPA17/MAP3K5/CCR3/GPC4/OSMR/ITGA3/CCR1/IL13RA2/CD24/THY1/ITGA6/IL6ST/IGLL1/ITGA2/ITGB1 27 CC GO:0070820 tertiary granule 14/839 164/19717 0.01045 0.0536 0.04006 CD55/PRCP/FPR1/ATP6V0A1/FOLR3/ITGB2/ATP6V0C/DIAPH1/SERPINB6/ASAH1/TCIRG1/PTX3/PGM1/PTPRB 14 CC GO:0031941 filamentous actin 5/839 32/19717 0.01068 0.05401 0.04036 PDLIM1/DPYSL3/SMTN/CD2AP/PDLIM7 5 CC GO:0030018 Z disc 12/839 132/19717 0.0107 0.05401 0.04036 ACTN1/CRYAB/PDLIM1/PALLD/CSRP2/PDE4B/FLNB/CAV3/CACNA1C/BIN1/PDLIM7/SORBS2 12 CC GO:0005838 proteasome regulatory particle 4/839 21/19717 0.01092 0.0547 0.04088 PSMD8/PSMD1/PSMD3/PSMD2 4 CC GO:0030120 vesicle coat 7/839 58/19717 0.01122 0.05575 0.04167 HIP1R/CLTB/KIAA1107/ARFGAP2/SEC13/AP2B1/SEC23B 7 CC GO:0031902 late endosome membrane 12/839 134/19717 0.01197 0.059 0.0441 VPS41/MMD/RAB27B/LAMTOR5/VPS11/GOSR2/FIG4/HLA-DRB4/CHMP2A/TSG101/STOML1/PIKFYVE 12 CC GO:1905368 peptidase complex 9/839 89/19717 0.01337 0.06538 0.04886 PSMD8/PSMB7/RAD23A/SPCS2/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8 9 CC GO:0045177 apical part of cell 26/839 384/19717 0.0137 0.0665 0.0497 HIP1R/ADCY8/ATP6V0D1/ATP6V1E1/GJA1/CLDN4/CHL1/GM2A/RAB27B/CIB1/FAP/SLC29A1/ITPR3/OSMR/PODXL/FZD6/THY1/DDR2/ATP1B1/TCIRG1/SLC9A3R2/EZR/CLIC5/BYSL/VAMP3/SORBS2 26 CC GO:0061695 transferase complex, transferring phosphorus-containing groups 19/839 259/19717 0.01522 0.07206 0.05385 POLR2L/POLR2E/PRIM2/TGFBR1/PIK3R1/PRPSAP2/CCND2/PIK3C3/POLE3/POLR3D/MAP3K5/POLR3G/PIK3R2/PIK3CB/SOCS5/SOCS3/PRIM1/POLD2/POLRMT 19 CC GO:0005766 primary lysosome 13/839 155/19717 0.01523 0.07206 0.05385 ATP8A1/PRCP/CTSC/FPR1/CTSA/GRN/PSMD1/GM2A/ATP11B/ATP6V0C/VAT1/GLIPR1/HEBP2 13 CC GO:0042582 azurophil granule 13/839 155/19717 0.01523 0.07206 0.05385 ATP8A1/PRCP/CTSC/FPR1/CTSA/GRN/PSMD1/GM2A/ATP11B/ATP6V0C/VAT1/GLIPR1/HEBP2 13 CC GO:0031594 neuromuscular junction 8/839 76/19717 0.0153 0.07206 0.05385 POSTN/SV2A/MYH9/SNTA1/CAV3/PDZRN3/UNC13B/ITGB1 8 CC GO:0005635 nuclear envelope 30/839 464/19717 0.01552 0.07256 0.05423 MAPK3/TM7SF2/RANGAP1/CLIC1/PLA2G4C/LBR/BCL2L1/ATP11B/CCND2/HAX1/ITPR3/NUP205/NUP93/NUP153/BANF1/DNAJC2/GPX4/SEC13/CHMP2A/UBE2I/CLIP1/IFI27/SIGMAR1/BCL2/PLCB1/BIN1/AGFG1/MX1/MX2/KPNA3 30 CC GO:0001931 uropod 3/839 13/19717 0.01595 0.07345 0.05489 MYH9/BST1/EZR 3 CC GO:0031254 cell trailing edge 3/839 13/19717 0.01595 0.07345 0.05489 MYH9/BST1/EZR 3 CC GO:0022624 proteasome accessory complex 4/839 24/19717 0.01754 0.07848 0.05865 PSMD8/PSMD1/PSMD3/PSMD2 4 CC GO:0031233 intrinsic component of external side of plasma membrane 4/839 24/19717 0.01754 0.07848 0.05865 FOLR3/FOLR2/CD24/THY1 4 CC GO:0043601 nuclear replisome 4/839 24/19717 0.01754 0.07848 0.05865 PRIM2/RPA3/PRIM1/POLD2 4 CC GO:0099522 region of cytosol 4/839 24/19717 0.01754 0.07848 0.05865 SH3GL2/PIN1/PRKCB/MTOR 4 CC GO:0016324 apical plasma membrane 22/839 318/19717 0.01774 0.07883 0.05891 HIP1R/ADCY8/ATP6V0D1/ATP6V1E1/GJA1/CLDN4/GM2A/RAB27B/CIB1/SLC29A1/OSMR/PODXL/FZD6/THY1/DDR2/ATP1B1/TCIRG1/SLC9A3R2/EZR/CLIC5/VAMP3/SORBS2 22 CC GO:0014704 intercalated disc 6/839 50/19717 0.01883 0.08309 0.0621 ACTN1/GJA1/GJC1/CAV3/ATP1B1/ITGB1 6 CC GO:0016528 sarcoplasm 8/839 80/19717 0.02032 0.08902 0.06653 THBS4/THBS1/ATP2A2/HABP4/HAX1/ITPR3/GSN/CALU 8 CC GO:0030117 membrane coat 9/839 96/19717 0.02103 0.09088 0.06792 HIP1R/VPS41/CLTB/KIAA1107/ARFGAP2/SEC13/CHMP2A/AP2B1/SEC23B 9 CC GO:0048475 coated membrane 9/839 96/19717 0.02103 0.09088 0.06792 HIP1R/VPS41/CLTB/KIAA1107/ARFGAP2/SEC13/CHMP2A/AP2B1/SEC23B 9 CC GO:0030894 replisome 4/839 26/19717 0.02308 0.0989 0.07391 PRIM2/RPA3/PRIM1/POLD2 4 CC GO:0098685 Schaffer collateral - CA1 synapse 8/839 82/19717 0.02322 0.0989 0.07391 CDH11/PTPRA/SH3GL2/ADCY8/ABR/STAT3/GABBR1/ITGB1 8 CC GO:0031093 platelet alpha granule lumen 7/839 67/19717 0.02344 0.0989 0.07391 ACTN1/THBS1/SPARC/VEGFC/PDGFA/TGFB2/GAS6 7 CC GO:0016323 basolateral plasma membrane 16/839 217/19717 0.02351 0.0989 0.07391 ENPP1/SLC7A8/SLC4A4/ADCY8/CLDN4/GM2A/ABCC4/SLC29A1/MET/ITGA3/MAP4K2/PALM/ATP1B1/ARRB2/ITGA6/EZR 16 CC GO:0030122 AP-2 adaptor complex 3/839 15/19717 0.02382 0.09953 0.07439 HIP1R/KIAA1107/AP2B1 3 CC GO:0120111 neuron projection cytoplasm 8/839 84/19717 0.0264 0.1096 0.08189 HIP1R/TRAK2/RANGAP1/RAB27B/HIF1A/TERF2/MAP2K4/MAP1A 8 CC GO:0005913 cell-cell adherens junction 10/839 117/19717 0.0276 0.1127 0.08425 ACTN1/CDH11/PDLIM1/ATP2A2/GJA1/CDC42EP1/MYH9/ITGA6/KRT18/PDLIM7 10 CC GO:0019898 extrinsic component of membrane 20/839 295/19717 0.02774 0.1127 0.08425 CDH11/ESYT1/ATP2A2/FOLR3/PIK3R1/ATG2A/PIK3C3/IQGAP1/DEFB1/PIK3R2/GNG12/PIK3CB/NMT1/BST1/STAC/SOCS5/SOCS3/NAAA/CYTH1/EZR 20 CC GO:0030128 clathrin coat of endocytic vesicle 3/839 16/19717 0.02841 0.1127 0.08425 HIP1R/KIAA1107/AP2B1 3 CC GO:0030479 actin cortical patch 3/839 16/19717 0.02841 0.1127 0.08425 HIP1R/CAPZA2/GMFG 3 CC GO:0033643 host cell part 3/839 16/19717 0.02841 0.1127 0.08425 PI4K2A/RAB29/LMAN1 3 CC GO:0042613 MHC class II protein complex 3/839 16/19717 0.02841 0.1127 0.08425 HLA-DRB4/HLA-DQB1/HLA-DPB1 3 CC GO:0061645 endocytic patch 3/839 16/19717 0.02841 0.1127 0.08425 HIP1R/CAPZA2/GMFG 3 CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 7/839 71/19717 0.03104 0.1216 0.09091 CD55/CTSC/GOSR2/COL7A1/TAP1/LMAN1/TMED2 7 CC GO:0098982 GABA-ergic synapse 7/839 71/19717 0.03104 0.1216 0.09091 GAP43/SV2A/KCND3/GABBR1/GLRB/PLCB1/ACAN 7 CC GO:0098798 mitochondrial protein complex 18/839 262/19717 0.03171 0.1235 0.0923 NDUFB8/SDHA/MRPL40/NDUFAB1/DNAJC11/NDUFS6/NDUFA7/NDUFS3/NDUFS7/MRPL28/UQCRQ/PDK1/SDHB/UQCRC1/NDUFA1/NDUFB7/PDK2/POLRMT 18 CC GO:0030658 transport vesicle membrane 15/839 208/19717 0.03279 0.1269 0.09482 SH3GL2/CLTB/SV2A/BCL2L1/RAB27B/GOSR2/HLA-DRB4/SEC13/HLA-DQB1/UNC13B/SEC23B/LMAN1/VAMP3/TMED2/HLA-DPB1 15 CC GO:0030125 clathrin vesicle coat 4/839 29/19717 0.03319 0.1269 0.09482 HIP1R/CLTB/KIAA1107/AP2B1 4 CC GO:0016607 nuclear speck 25/839 397/19717 0.03352 0.1269 0.09482 THOC1/PNN/ATP6V0A1/PIN1/MAML1/HABP4/MBD4/LUC7L3/SETD1B/POLR3D/SMC5/HIF1A/DDX39A/EPAS1/RBM39/SYF2/WBP4/SAP18/PLCB1/PIP5K1A/PNISR/SRSF7/HSF4/IK/RCHY1 25 CC GO:0016328 lateral plasma membrane 6/839 57/19717 0.03358 0.1269 0.09482 GJA1/CLDN4/SNTA1/IQGAP1/ARL2/PPP2R1A 6 CC GO:1904115 axon cytoplasm 6/839 57/19717 0.03358 0.1269 0.09482 TRAK2/RANGAP1/RAB27B/HIF1A/TERF2/MAP1A 6 CC GO:0005643 nuclear pore 8/839 89/19717 0.03564 0.1339 0.1 RANGAP1/NUP205/NUP93/NUP153/SEC13/AGFG1/MX2/KPNA3 8 CC GO:0035577 azurophil granule membrane 6/839 58/19717 0.03616 0.135 0.1009 ATP8A1/PRCP/FPR1/ATP11B/ATP6V0C/GLIPR1 6 CC GO:0002102 podosome 4/839 30/19717 0.03705 0.1375 0.1028 PALLD/GSN/FSCN1/SH3PXD2A 4 CC GO:0055037 recycling endosome 13/839 176/19717 0.03806 0.1404 0.105 SLC31A2/PLEKHB2/SCAMP3/ABCG1/FZD7/ATP11B/MYO5A/DYNC1I1/FIG4/RAB8A/RAB29/VAMP3/ITGB1 13 CC GO:0016327 apicolateral plasma membrane 3/839 18/19717 0.03888 0.1412 0.1055 CLDN4/FZD6/PALM 3 CC GO:0032433 filopodium tip 3/839 18/19717 0.03888 0.1412 0.1055 MYO10/CIB1/MYO5A 3 CC GO:1904813 ficolin-1-rich granule lumen 10/839 124/19717 0.03892 0.1412 0.1055 PLEKHO2/PSMB7/XRCC6/GSN/ASAH1/CAT/PSMD3/PGM1/PSMD2/GMFG 10 CC GO:0031091 platelet alpha granule 8/839 91/19717 0.03989 0.1431 0.107 ACTN1/THBS1/SPARC/VEGFC/ITGB3/PDGFA/TGFB2/GAS6 8 CC GO:0005667 transcription factor complex 23/839 365/19717 0.03992 0.1431 0.107 VDR/SATB2/ARNTL/TCF7L2/LMO2/PDLIM1/RFX3/NR1H2/WWTR1/NR1H3/XRCC6/HAX1/HIF1A/EPAS1/TEAD3/STAT3/TLE4/SNAPC4/KLF4/SOX4/HMGA1/TEAD4/NFYB 23 CC GO:0005865 striated muscle thin filament 4/839 31/19717 0.04115 0.1467 0.1096 TPM2/TPM1/TMOD1/LMOD1 4 CC GO:0044853 plasma membrane raft 9/839 109/19717 0.04283 0.1518 0.1135 MAPK3/CLN3/ADCY8/ITGB2/HAS2/CAV3/ATP1B1/JAK2/EZR 9 CC GO:0016010 dystrophin-associated glycoprotein complex 3/839 19/19717 0.04475 0.1564 0.1169 SNTA1/CAV3/SGCA 3 CC GO:0090665 glycoprotein complex 3/839 19/19717 0.04475 0.1564 0.1169 SNTA1/CAV3/SGCA 3 CC GO:0030118 clathrin coat 5/839 46/19717 0.04486 0.1564 0.1169 HIP1R/VPS41/CLTB/KIAA1107/AP2B1 5 CC GO:0036379 myofilament 4/839 32/19717 0.0455 0.1578 0.1179 TPM2/TPM1/TMOD1/LMOD1 4 CC GO:0097060 synaptic membrane 26/839 432/19717 0.04855 0.1674 0.1251 PI4K2A/PTPRA/HIP1R/CRYAB/CLTB/ADCY8/EPHB2/KCND3/DDN/KIAA1107/EXOC3/NRP1/GPC4/ITGA3/NDUFS7/PALM/ARRB2/GABBR1/GLRB/GRIN2B/SIGMAR1/UNC13B/CACNA1C/NRP2/GRIN2A/ITGB1 26 CC GO:0005839 proteasome core complex 3/839 20/19717 0.05104 0.1731 0.1294 PSMB7/PSMB6/PSMB8 3 CC GO:0030663 COPI-coated vesicle membrane 3/839 20/19717 0.05104 0.1731 0.1294 KDELR3/ARFGAP2/TMED2 3 CC GO:0043194 axon initial segment 3/839 20/19717 0.05104 0.1731 0.1294 CNGA3/BIN1/MAP1A 3 CC GO:0098862 cluster of actin-based cell projections 11/839 150/19717 0.05572 0.188 0.1405 ACTN1/CLIC1/MYH9/CAPZA2/ITPR3/FLII/TWF2/EPS8/FLNB/MFSD10/EZR 11 CC GO:0043197 dendritic spine 12/839 169/19717 0.05754 0.1927 0.144 HIP1R/CRYAB/NTRK2/ARF4/DDN/PDE4B/PALM/ARRB2/RAB8A/LPAR1/GRIN2A/ITGB1 12 CC GO:0042827 platelet dense granule 3/839 21/19717 0.05772 0.1927 0.144 RARRES2/RAB27B/ABCC4 3 CC GO:0030863 cortical cytoskeleton 9/839 116/19717 0.05928 0.1969 0.1471 HIP1R/MYH9/MYRIP/TMOD1/CAPZA2/GSN/SPTBN1/EZR/GMFG 9 CC GO:0005777 peroxisome 10/839 134/19717 0.0601 0.1975 0.1476 IDH2/HMGCL/PIK3C3/MYO5A/MPV17/PEX7/HSDL2/TTC1/CAT/CRYM 10 CC GO:0042579 microbody 10/839 134/19717 0.0601 0.1975 0.1476 IDH2/HMGCL/PIK3C3/MYO5A/MPV17/PEX7/HSDL2/TTC1/CAT/CRYM 10 CC GO:0034707 chloride channel complex 5/839 50/19717 0.06051 0.1978 0.1478 CLIC2/CLIC1/CLDN4/GLRB/CLIC5 5 CC GO:0044309 neuron spine 12/839 171/19717 0.06178 0.2009 0.1502 HIP1R/CRYAB/NTRK2/ARF4/DDN/PDE4B/PALM/ARRB2/RAB8A/LPAR1/GRIN2A/ITGB1 12 CC GO:0000776 kinetochore 10/839 135/19717 0.06257 0.2017 0.1507 RANGAP1/PHF2/KAT2B/ITGB3BP/RASSF2/DYNC1I1/SEC13/CLIP1/KIF2C/CKAP5 10 CC GO:0005902 microvillus 7/839 83/19717 0.06314 0.2017 0.1507 ANGPT1/ATP6V1E1/ITGB3/PODXL/PDGFA/FSCN1/EZR 7 CC GO:0009898 cytoplasmic side of plasma membrane 11/839 154/19717 0.0648 0.2017 0.1507 ESYT1/ATP2A2/GM2A/NPTX2/IQGAP1/GNG12/PALM/RGS2/STAC/CYTH1/EZR 11 CC GO:0031258 lamellipodium membrane 3/839 22/19717 0.0648 0.2017 0.1507 PLXND1/FAP/ITGB3 3 CC GO:0001527 microfibril 2/839 10/19717 0.06488 0.2017 0.1507 LTBP1/FBN2 2 CC GO:0005916 fascia adherens 2/839 10/19717 0.06488 0.2017 0.1507 ACTN1/GJA1 2 CC GO:0033655 host cell cytoplasm part 2/839 10/19717 0.06488 0.2017 0.1507 RAB29/LMAN1 2 CC GO:0043256 laminin complex 2/839 10/19717 0.06488 0.2017 0.1507 LAMB1/LAMA1 2 CC GO:0072588 box H/ACA RNP complex 2/839 10/19717 0.06488 0.2017 0.1507 NOLC1/NHP2 2 CC GO:0008180 COP9 signalosome 4/839 36/19717 0.06537 0.2022 0.1511 HSPA5/MYH9/TMOD1/COPS8 4 CC GO:0044304 main axon 6/839 68/19717 0.06893 0.2122 0.1586 MYOC/THY1/CNGA3/BIN1/SPTBN1/MAP1A 6 CC GO:0030315 T-tubule 5/839 52/19717 0.06935 0.2124 0.1588 CAV3/STAC/CACNA1C/BIN1/EZR 5 CC GO:0031528 microvillus membrane 3/839 23/19717 0.07225 0.2194 0.164 ITGB3/PODXL/EZR 3 CC GO:0098984 neuron to neuron synapse 21/839 350/19717 0.07232 0.2194 0.164 HIP1R/CRYAB/SH3GL2/ADCY8/TANC2/GAP43/NTRK2/ABR/PDE4B/EPS8/PALM/STAT3/ARRB2/GRIN2B/RAB8A/SIGMAR1/UNC13B/CACNA1C/SPTBN1/GRIN2A/CAMK1 21 CC GO:0030430 host cell cytoplasm 2/839 11/19717 0.07712 0.2285 0.1707 RAB29/LMAN1 2 CC GO:0031094 platelet dense tubular network 2/839 11/19717 0.07712 0.2285 0.1707 ATP2A2/ITPR3 2 CC GO:0034663 endoplasmic reticulum chaperone complex 2/839 11/19717 0.07712 0.2285 0.1707 HSPA5/PPIB 2 CC GO:0042589 zymogen granule membrane 2/839 11/19717 0.07712 0.2285 0.1707 RAB27B/TMED2 2 CC GO:1990907 beta-catenin-TCF complex 2/839 11/19717 0.07712 0.2285 0.1707 TCF7L2/TLE4 2 CC GO:0044452 nucleolar part 12/839 178/19717 0.07823 0.2307 0.1724 POLR2L/KLF6/POLR2E/SAMD4A/WDR43/NOLC1/LIPA/RRS1/RSAD2/CHD1/NHP2/EZR 12 CC GO:0000178 exosome (RNase complex) 3/839 24/19717 0.08007 0.2339 0.1748 EXOSC7/ZFC3H1/EXOSC2 3 CC GO:0097386 glial cell projection 3/839 24/19717 0.08007 0.2339 0.1748 CNGA3/EZR/ITGB1 3 CC GO:0016529 sarcoplasmic reticulum 6/839 71/19717 0.08129 0.2353 0.1758 THBS4/THBS1/ATP2A2/HAX1/ITPR3/CALU 6 CC GO:0044291 cell-cell contact zone 6/839 71/19717 0.08129 0.2353 0.1758 ACTN1/GJA1/GJC1/CAV3/ATP1B1/ITGB1 6 CC GO:0031965 nuclear membrane 18/839 296/19717 0.0825 0.2377 0.1776 TM7SF2/RANGAP1/CLIC1/LBR/BCL2L1/ATP11B/CCND2/HAX1/ITPR3/NUP205/NUP93/NUP153/DNAJC2/IFI27/SIGMAR1/BCL2/PLCB1/MX1 18 CC GO:0042611 MHC protein complex 3/839 25/19717 0.08823 0.2513 0.1878 HLA-DRB4/HLA-DQB1/HLA-DPB1 3 CC GO:1905354 exoribonuclease complex 3/839 25/19717 0.08823 0.2513 0.1878 EXOSC7/ZFC3H1/EXOSC2 3 CC GO:0030864 cortical actin cytoskeleton 7/839 90/19717 0.08871 0.2513 0.1878 HIP1R/MYH9/MYRIP/CAPZA2/GSN/SPTBN1/GMFG 7 CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 9/839 126/19717 0.08902 0.2513 0.1878 CD55/CTSC/SERPINH1/HSPA5/GOSR2/COL7A1/TAP1/LMAN1/TMED2 9 CC GO:0005614 interstitial matrix 2/839 12/19717 0.09001 0.2513 0.1878 KAZALD1/TNC 2 CC GO:0008540 proteasome regulatory particle, base subcomplex 2/839 12/19717 0.09001 0.2513 0.1878 PSMD1/PSMD2 2 CC GO:0030897 HOPS complex 2/839 12/19717 0.09001 0.2513 0.1878 VPS41/VPS11 2 CC GO:0035578 azurophil granule lumen 7/839 91/19717 0.09278 0.2579 0.1927 CTSC/CTSA/GRN/PSMD1/GM2A/VAT1/HEBP2 7 CC GO:0044448 cell cortex part 12/839 184/19717 0.09435 0.2611 0.1952 HIP1R/CLTB/MYH9/EXOC3/MYRIP/TMOD1/CAPZA2/GSN/UNC13B/SPTBN1/EZR/GMFG 12 CC GO:0043596 nuclear replication fork 4/839 41/19717 0.0955 0.2631 0.1967 PRIM2/RPA3/PRIM1/POLD2 4 CC GO:0036452 ESCRT complex 3/839 26/19717 0.09673 0.2648 0.1979 STAM/CHMP2A/TSG101 3 CC GO:0032588 trans-Golgi network membrane 7/839 92/19717 0.09695 0.2648 0.1979 SCAMP3/HLA-DRB4/RAB8A/HLA-DQB1/COG4/VAMP3/HLA-DPB1 7 CC GO:0014069 postsynaptic density 19/839 324/19717 0.09932 0.2701 0.2019 HIP1R/CRYAB/ADCY8/TANC2/GAP43/NTRK2/ABR/PDE4B/EPS8/PALM/STAT3/ARRB2/GRIN2B/RAB8A/SIGMAR1/CACNA1C/SPTBN1/GRIN2A/CAMK1 19 CC GO:0005637 nuclear inner membrane 5/839 58/19717 0.09988 0.2705 0.2022 TM7SF2/LBR/ATP11B/IFI27/SIGMAR1 5 CC GO:0000782 telomere cap complex 2/839 13/19717 0.1035 0.2742 0.2049 XRCC6/TERF2 2 CC GO:0000783 nuclear telomere cap complex 2/839 13/19717 0.1035 0.2742 0.2049 XRCC6/TERF2 2 CC GO:0005736 RNA polymerase I complex 2/839 13/19717 0.1035 0.2742 0.2049 POLR2L/POLR2E 2 CC GO:0032591 dendritic spine membrane 2/839 13/19717 0.1035 0.2742 0.2049 DDN/PALM 2 CC GO:0033391 chromatoid body 2/839 13/19717 0.1035 0.2742 0.2049 ARNTL/TDRD7 2 CC GO:0005795 Golgi stack 10/839 149/19717 0.1038 0.2742 0.2049 CHSY1/CLN3/NSFL1C/B4GALT2/RAB27B/ST6GAL1/SULF1/INPP5E/MBTPS1/TMED2 10 CC GO:0046658 anchored component of plasma membrane 5/839 59/19717 0.1055 0.2763 0.2065 FOLR3/FOLR2/GPC4/CD24/THY1 5 CC GO:0030137 COPI-coated vesicle 3/839 27/19717 0.1055 0.2763 0.2065 KDELR3/ARFGAP2/TMED2 3 CC GO:0099572 postsynaptic specialization 20/839 348/19717 0.1076 0.2805 0.2096 HIP1R/CRYAB/ADCY8/TANC2/GAP43/NTRK2/KCND3/ABR/PDE4B/EPS8/PALM/STAT3/ARRB2/GRIN2B/RAB8A/SIGMAR1/CACNA1C/SPTBN1/GRIN2A/CAMK1 20 CC GO:0032279 asymmetric synapse 19/839 328/19717 0.1083 0.2813 0.2102 HIP1R/CRYAB/ADCY8/TANC2/GAP43/NTRK2/ABR/PDE4B/EPS8/PALM/STAT3/ARRB2/GRIN2B/RAB8A/SIGMAR1/CACNA1C/SPTBN1/GRIN2A/CAMK1 19 CC GO:0005938 cell cortex 18/839 308/19717 0.1089 0.2816 0.2105 HIP1R/CLTB/PLA2G4C/MYO10/MYH9/EXOC3/MYRIP/TMOD1/CAPZA2/HAX1/GSN/EPS8/FLNB/UNC13B/SPTBN1/EZR/CLIC5/GMFG 18 CC GO:0001650 fibrillar center 9/839 132/19717 0.1104 0.2845 0.2126 KLF6/SAMD4A/WDR43/NOLC1/LIPA/RRS1/RSAD2/CHD1/EZR 9 CC GO:0044455 mitochondrial membrane part 14/839 229/19717 0.1116 0.2861 0.2138 NDUFB8/SDHA/NDUFAB1/DNAJC11/NDUFS6/NDUFA7/NDUFS3/NDUFS7/UQCRQ/SDHB/UQCRC1/COX7A2/NDUFA1/NDUFB7 14 CC GO:0000177 cytoplasmic exosome (RNase complex) 2/839 14/19717 0.1174 0.2861 0.2138 EXOSC7/EXOSC2 2 CC GO:0000346 transcription export complex 2/839 14/19717 0.1174 0.2861 0.2138 THOC1/DDX39A 2 CC GO:0005750 mitochondrial respiratory chain complex III 2/839 14/19717 0.1174 0.2861 0.2138 UQCRQ/UQCRC1 2 CC GO:0030673 axolemma 2/839 14/19717 0.1174 0.2861 0.2138 THY1/SPTBN1 2 CC GO:0033162 melanosome membrane 2/839 14/19717 0.1174 0.2861 0.2138 RAB32/TYR 2 CC GO:0033646 host intracellular part 2/839 14/19717 0.1174 0.2861 0.2138 RAB29/LMAN1 2 CC GO:0036020 endolysosome membrane 2/839 14/19717 0.1174 0.2861 0.2138 CLEC16A/AP2B1 2 CC GO:0042588 zymogen granule 2/839 14/19717 0.1174 0.2861 0.2138 RAB27B/TMED2 2 CC GO:0043656 intracellular region of host 2/839 14/19717 0.1174 0.2861 0.2138 RAB29/LMAN1 2 CC GO:0045009 chitosome 2/839 14/19717 0.1174 0.2861 0.2138 RAB32/TYR 2 CC GO:0045275 respiratory chain complex III 2/839 14/19717 0.1174 0.2861 0.2138 UQCRQ/UQCRC1 2 CC GO:0090741 pigment granule membrane 2/839 14/19717 0.1174 0.2861 0.2138 RAB32/TYR 2 CC GO:0099523 presynaptic cytosol 2/839 14/19717 0.1174 0.2861 0.2138 SH3GL2/PRKCB 2 CC GO:0005758 mitochondrial intermembrane space 6/839 79/19717 0.1198 0.2907 0.2172 MYOC/HAX1/TRAP1/ARL2/CAT/NDUFB7 6 CC GO:0030496 midbody 11/839 173/19717 0.1205 0.2913 0.2177 PIN1/HSPA5/PIK3C3/IQGAP1/EXOC3/MAPRE3/PIK3CB/RAB8A/ZNF330/TSG101/PKN1 11 CC GO:0000775 chromosome, centromeric region 12/839 193/19717 0.1221 0.294 0.2197 RANGAP1/PHF2/KAT2B/ITGB3BP/RASSF2/DYNC1I1/SEC13/CLIP1/ZNF330/PPP2R1A/KIF2C/CKAP5 12 CC GO:0030119 AP-type membrane coat adaptor complex 4/839 45/19717 0.1235 0.2943 0.2199 HIP1R/VPS41/KIAA1107/AP2B1 4 CC GO:0030131 clathrin adaptor complex 3/839 29/19717 0.1241 0.2943 0.2199 HIP1R/KIAA1107/AP2B1 3 CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 3/839 29/19717 0.1241 0.2943 0.2199 HLA-DRB4/HLA-DQB1/HLA-DPB1 3 CC GO:0098553 lumenal side of endoplasmic reticulum membrane 3/839 29/19717 0.1241 0.2943 0.2199 HLA-DRB4/HLA-DQB1/HLA-DPB1 3 CC GO:0005901 caveola 6/839 80/19717 0.1251 0.2957 0.221 MAPK3/CLN3/ADCY8/CAV3/ATP1B1/JAK2 6 CC GO:0098802 plasma membrane receptor complex 17/839 295/19717 0.1275 0.3003 0.2244 IL18R1/EMILIN1/RAMP2/ITGA1/TGFBR1/ITGB2/OSMR/ITGB3/ITGA3/EPS8/GABBR1/ITGA6/GRIN2B/IL6ST/ITGA2/GRIN2A/ITGB1 17 CC GO:0016605 PML body 7/839 99/19717 0.1289 0.3025 0.2261 ARNTL/TCF7L2/ZMYM2/TDP2/SMC5/UBE2I/MTOR 7 CC GO:0005811 lipid droplet 6/839 81/19717 0.1306 0.3025 0.2261 ABHD5/ATG2A/FIG4/PNPLA2/RSAD2/SIGMAR1 6 CC GO:0055038 recycling endosome membrane 6/839 81/19717 0.1306 0.3025 0.2261 PLEKHB2/SCAMP3/FZD7/ATP11B/RAB8A/VAMP3 6 CC GO:0005665 RNA polymerase II, core complex 2/839 15/19717 0.1318 0.3025 0.2261 POLR2L/POLR2E 2 CC GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex 2/839 15/19717 0.1318 0.3025 0.2261 KAT2B/POLE3 2 CC GO:0030127 COPII vesicle coat 2/839 15/19717 0.1318 0.3025 0.2261 SEC13/SEC23B 2 CC GO:0033268 node of Ranvier 2/839 15/19717 0.1318 0.3025 0.2261 MYOC/BIN1 2 CC GO:0098562 cytoplasmic side of membrane 11/839 178/19717 0.1386 0.3168 0.2367 ESYT1/ATP2A2/GM2A/NPTX2/IQGAP1/GNG12/PALM/RGS2/STAC/CYTH1/EZR 11 CC GO:0030140 trans-Golgi network transport vesicle 3/839 31/19717 0.1436 0.3272 0.2446 CLTB/RAB27B/RAB8A 3 CC GO:0042575 DNA polymerase complex 2/839 16/19717 0.1466 0.3328 0.2487 POLE3/POLD2 2 CC GO:0000932 P-body 6/839 84/19717 0.1477 0.334 0.2496 SAMD4A/HAX1/TNRC6B/ZFP36/APOBEC3C/LSM4 6 CC GO:0099023 tethering complex 5/839 66/19717 0.1492 0.3352 0.2505 VPS41/EXOC3/MYRIP/VPS11/COG4 5 CC GO:0042734 presynaptic membrane 10/839 161/19717 0.1493 0.3352 0.2505 PI4K2A/CLTB/ADCY8/EPHB2/KIAA1107/EXOC3/GPC4/GABBR1/UNC13B/GRIN2A 10 CC GO:0044798 nuclear transcription factor complex 12/839 201/19717 0.1501 0.336 0.2511 VDR/TCF7L2/NR1H2/NR1H3/HIF1A/STAT3/TLE4/SNAPC4/KLF4/SOX4/HMGA1/NFYB 12 CC GO:0032839 dendrite cytoplasm 3/839 32/19717 0.1538 0.3424 0.2559 HIP1R/TRAK2/MAP2K4 3 CC GO:0030672 synaptic vesicle membrane 7/839 104/19717 0.1547 0.3424 0.2559 SH3GL2/CLTB/SV2A/BCL2L1/RAB27B/UNC13B/VAMP3 7 CC GO:0099501 exocytic vesicle membrane 7/839 104/19717 0.1547 0.3424 0.2559 SH3GL2/CLTB/SV2A/BCL2L1/RAB27B/UNC13B/VAMP3 7 CC GO:0000777 condensed chromosome kinetochore 7/839 105/19717 0.1601 0.3507 0.2621 RANGAP1/PHF2/ITGB3BP/RASSF2/DYNC1I1/KIF2C/CKAP5 7 CC GO:0000176 nuclear exosome (RNase complex) 2/839 17/19717 0.1617 0.3507 0.2621 EXOSC7/EXOSC2 2 CC GO:0031092 platelet alpha granule membrane 2/839 17/19717 0.1617 0.3507 0.2621 SPARC/ITGB3 2 CC GO:0031143 pseudopodium 2/839 17/19717 0.1617 0.3507 0.2621 MAPK3/ACTN1 2 CC GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain 2/839 17/19717 0.1617 0.3507 0.2621 ATP6V1E1/ATP6V1H 2 CC GO:0099524 postsynaptic cytosol 2/839 17/19717 0.1617 0.3507 0.2621 PIN1/MTOR 2 CC GO:0005771 multivesicular body 4/839 51/19717 0.171 0.367 0.2743 GJA1/RAB27B/CHMP2A/TSG101 4 CC GO:0005782 peroxisomal matrix 4/839 51/19717 0.171 0.367 0.2743 HMGCL/PEX7/CAT/CRYM 4 CC GO:0031907 microbody lumen 4/839 51/19717 0.171 0.367 0.2743 HMGCL/PEX7/CAT/CRYM 4 CC GO:0031970 organelle envelope lumen 6/839 88/19717 0.1719 0.3677 0.2748 MYOC/HAX1/TRAP1/ARL2/CAT/NDUFB7 6 CC GO:0005790 smooth endoplasmic reticulum 3/839 34/19717 0.1747 0.37 0.2765 HSPA5/MYO5A/PPIB 3 CC GO:0009925 basal plasma membrane 3/839 34/19717 0.1747 0.37 0.2765 CLDN4/MET/ITGA6 3 CC GO:0098686 hippocampal mossy fiber to CA3 synapse 3/839 34/19717 0.1747 0.37 0.2765 SH3GL2/ADCY8/UNC13B 3 CC GO:0000428 DNA-directed RNA polymerase complex 7/839 108/19717 0.1768 0.37 0.2765 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1/POLRMT 7 CC GO:0090723 growth cone part 2/839 18/19717 0.1771 0.37 0.2765 GAP43/ITGA3 2 CC GO:0099092 postsynaptic density, intracellular component 2/839 18/19717 0.1771 0.37 0.2765 TANC2/ABR 2 CC GO:0005657 replication fork 5/839 70/19717 0.1771 0.37 0.2765 PRIM2/RFC3/RPA3/PRIM1/POLD2 5 CC GO:0000790 nuclear chromatin 20/839 377/19717 0.1841 0.3819 0.2854 NACC2/TCF7L2/RFX3/FOXC1/SMARCA1/NR1H3/SNAI2/POLR3D/POGZ/WBP2/HIF1A/POLR3G/STAT3/KLF4/ANP32E/PLCB1/ASF1A/SMARCE1/PAWR/CREBBP 20 CC GO:0048786 presynaptic active zone 5/839 71/19717 0.1843 0.3819 0.2854 ADCY8/PPFIA4/SV2A/UNC13B/PNISR 5 CC GO:0005684 U2-type spliceosomal complex 6/839 90/19717 0.1846 0.3819 0.2854 LUC7L3/SYF2/WBP4/LSM4/IK/HTATSF1 6 CC GO:0031225 anchored component of membrane 10/839 170/19717 0.1889 0.3896 0.2912 CD55/FOLR3/FOLR2/RAB27B/GPC4/CD24/THY1/BST1/MMP17/CPM 10 CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 6/839 91/19717 0.1911 0.3921 0.293 ESYT1/ATP2A2/IQGAP1/GNG12/STAC/CYTH1 6 CC GO:0000145 exocyst 2/839 19/19717 0.1926 0.3921 0.293 EXOC3/MYRIP 2 CC GO:0000159 protein phosphatase type 2A complex 2/839 19/19717 0.1926 0.3921 0.293 PPP2R1A/PPP2R5D 2 CC GO:0031045 dense core granule 2/839 19/19717 0.1926 0.3921 0.293 SCG2/MYRIP 2 CC GO:0036464 cytoplasmic ribonucleoprotein granule 12/839 212/19717 0.1937 0.393 0.2937 ARNTL/HABP4/SAMD4A/TDRD7/GHR/IQGAP1/HAX1/TNRC6B/DYNC1I1/ZFP36/APOBEC3C/LSM4 12 CC GO:0034399 nuclear periphery 8/839 131/19717 0.1952 0.3948 0.295 SATB2/THOC1/SPARC/ENC1/NUP205/NUP93/NUP153/JAK2 8 CC GO:0001772 immunological synapse 3/839 36/19717 0.1964 0.396 0.2959 MYH9/SNX27/EZR 3 CC GO:0030880 RNA polymerase complex 7/839 112/19717 0.2002 0.4022 0.3006 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1/POLRMT 7 CC GO:0032154 cleavage furrow 4/839 55/19717 0.2057 0.4107 0.3069 MYH9/MYLK/PKN1/ITGB1 4 CC GO:1904724 tertiary granule lumen 4/839 55/19717 0.2057 0.4107 0.3069 FOLR3/ASAH1/PTX3/PGM1 4 CC GO:0031082 BLOC complex 2/839 20/19717 0.2084 0.4122 0.308 PI4K2A/HPS1 2 CC GO:0035145 exon-exon junction complex 2/839 20/19717 0.2084 0.4122 0.308 PNN/SAP18 2 CC GO:0036019 endolysosome 2/839 20/19717 0.2084 0.4122 0.308 CLEC16A/AP2B1 2 CC GO:1902495 transmembrane transporter complex 17/839 324/19717 0.2203 0.4343 0.3246 CLIC2/CLIC1/CLDN4/KCND3/HSPA2/PDE4B/KCNN4/EPS8/ATP1B1/CNGA3/GLRB/GRIN2B/KCNMB1/CACNA1C/TRPC6/CLIC5/GRIN2A 17 CC GO:0032589 neuron projection membrane 4/839 57/19717 0.2237 0.4367 0.3264 DDN/THY1/PALM/SPTBN1 4 CC GO:0000930 gamma-tubulin complex 2/839 21/19717 0.2242 0.4367 0.3264 PDE4B/CKAP5 2 CC GO:0005922 connexin complex 2/839 21/19717 0.2242 0.4367 0.3264 GJA1/GJC1 2 CC GO:0099091 postsynaptic specialization, intracellular component 2/839 21/19717 0.2242 0.4367 0.3264 TANC2/ABR 2 CC GO:0031672 A band 3/839 39/19717 0.23 0.4452 0.3327 CRYAB/KAT2B/SPTBN1 3 CC GO:0032994 protein-lipid complex 3/839 39/19717 0.23 0.4452 0.3327 PLTP/BIN1/VLDLR 3 CC GO:0000779 condensed chromosome, centromeric region 7/839 118/19717 0.2373 0.4579 0.3422 RANGAP1/PHF2/ITGB3BP/RASSF2/DYNC1I1/KIF2C/CKAP5 7 CC GO:0097038 perinuclear endoplasmic reticulum 2/839 22/19717 0.2402 0.4606 0.3442 CREB3L2/PIK3R1 2 CC GO:0032590 dendrite membrane 3/839 40/19717 0.2415 0.4606 0.3442 DDN/THY1/PALM 3 CC GO:0042581 specific granule 9/839 160/19717 0.2423 0.4606 0.3442 ATP8A1/FOLR3/ITGB2/ANXA3/BST1/CHI3L1/ATP6V1D/PTX3/PTPRB 9 CC GO:0000793 condensed chromosome 12/839 223/19717 0.2423 0.4606 0.3442 RANGAP1/PHF2/ITGB3BP/HSPA2/RASSF2/SMC5/DYNC1I1/RRS1/BANF1/UBE2I/KIF2C/CKAP5 12 CC GO:0035770 ribonucleoprotein granule 12/839 223/19717 0.2423 0.4606 0.3442 ARNTL/HABP4/SAMD4A/TDRD7/GHR/IQGAP1/HAX1/TNRC6B/DYNC1I1/ZFP36/APOBEC3C/LSM4 12 CC GO:1990351 transporter complex 17/839 332/19717 0.2501 0.4734 0.3538 CLIC2/CLIC1/CLDN4/KCND3/HSPA2/PDE4B/KCNN4/EPS8/ATP1B1/CNGA3/GLRB/GRIN2B/KCNMB1/CACNA1C/TRPC6/CLIC5/GRIN2A 17 CC GO:0005778 peroxisomal membrane 4/839 60/19717 0.2515 0.4734 0.3538 MPV17/PEX7/TTC1/CAT 4 CC GO:0031903 microbody membrane 4/839 60/19717 0.2515 0.4734 0.3538 MPV17/PEX7/TTC1/CAT 4 CC GO:0044438 microbody part 6/839 100/19717 0.2529 0.4734 0.3538 HMGCL/MPV17/PEX7/TTC1/CAT/CRYM 6 CC GO:0044439 peroxisomal part 6/839 100/19717 0.2529 0.4734 0.3538 HMGCL/MPV17/PEX7/TTC1/CAT/CRYM 6 CC GO:0090575 RNA polymerase II transcription factor complex 9/839 163/19717 0.259 0.4834 0.3613 VDR/TCF7L2/NR1H2/NR1H3/HIF1A/STAT3/TLE4/HMGA1/NFYB 9 CC GO:0099240 intrinsic component of synaptic membrane 9/839 164/19717 0.2646 0.4925 0.3681 PTPRA/ADCY8/EPHB2/KCND3/NRP1/GPC4/NRP2/GRIN2A/ITGB1 9 CC GO:0044305 calyx of Held 2/839 24/19717 0.2722 0.5047 0.3772 PRKCB/UNC13B 2 CC GO:0032838 plasma membrane bounded cell projection cytoplasm 11/839 208/19717 0.2728 0.5047 0.3772 HIP1R/TRAK2/RANGAP1/RAB27B/PIK3C3/HIF1A/TERF2/INPP5E/MAP2K4/MAP1A/MAP1LC3B 11 CC GO:0005891 voltage-gated calcium channel complex 3/839 43/19717 0.2762 0.5097 0.3809 HSPA2/PDE4B/CACNA1C 3 CC GO:0032155 cell division site part 4/839 63/19717 0.28 0.515 0.3849 MYH9/MYLK/PKN1/ITGB1 4 CC GO:0030057 desmosome 2/839 25/19717 0.2882 0.5286 0.395 PNN/UBA1 2 CC GO:0008287 protein serine/threonine phosphatase complex 3/839 45/19717 0.2997 0.5466 0.4085 PPP2R1A/PPP2R5D/NCK1 3 CC GO:1903293 phosphatase complex 3/839 45/19717 0.2997 0.5466 0.4085 PPP2R1A/PPP2R5D/NCK1 3 CC GO:0034702 ion channel complex 15/839 301/19717 0.3018 0.5488 0.4102 CLIC2/CLIC1/CLDN4/KCND3/HSPA2/PDE4B/KCNN4/EPS8/GLRB/GRIN2B/KCNMB1/CACNA1C/TRPC6/CLIC5/GRIN2A 15 CC GO:0005640 nuclear outer membrane 2/839 26/19717 0.3041 0.55 0.4111 ITPR3/SIGMAR1 2 CC GO:0055029 nuclear DNA-directed RNA polymerase complex 6/839 107/19717 0.3042 0.55 0.4111 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1 6 CC GO:0098687 chromosomal region 17/839 349/19717 0.3182 0.5697 0.4257 THOC1/RANGAP1/PHF2/KAT2B/ITGB3BP/RASSF2/XRCC6/SMC5/DYNC1I1/TERF2/SEC13/CLIP1/NHP2/ZNF330/PPP2R1A/KIF2C/CKAP5 17 CC GO:0005874 microtubule 20/839 416/19717 0.3191 0.5697 0.4257 HAUS7/TBCE/KLHL21/MTUS2/IQGAP1/FKBP4/MYO5A/DYNC1I1/MAPRE3/NEK7/CLIP1/ROR2/CCT7/CAMSAP2/NUDC/MAP1A/KIF2C/MAP1LC3B/CKAP5/EML1 20 CC GO:0072686 mitotic spindle 6/839 109/19717 0.3192 0.5697 0.4257 ESPL1/RANGAP1/DIAPH1/MAPRE3/IK/EML1 6 CC GO:0032809 neuronal cell body membrane 2/839 27/19717 0.32 0.5697 0.4257 ADCY8/THY1 2 CC GO:0097431 mitotic spindle pole 2/839 27/19717 0.32 0.5697 0.4257 IK/EML1 2 CC GO:0099699 integral component of synaptic membrane 8/839 152/19717 0.3205 0.5697 0.4257 PTPRA/ADCY8/EPHB2/KCND3/NRP1/NRP2/GRIN2A/ITGB1 8 CC GO:0031201 SNARE complex 3/839 47/19717 0.3233 0.5714 0.427 GOSR2/NAPA/VAMP3 3 CC GO:0098563 intrinsic component of synaptic vesicle membrane 3/839 47/19717 0.3233 0.5714 0.427 SV2A/RAB27B/VAMP3 3 CC GO:0032153 cell division site 4/839 68/19717 0.3283 0.5787 0.4325 MYH9/MYLK/PKN1/ITGB1 4 CC GO:0005732 small nucleolar ribonucleoprotein complex 2/839 28/19717 0.3358 0.5853 0.4374 NOLC1/NHP2 2 CC GO:0031430 M band 2/839 28/19717 0.3358 0.5853 0.4374 CRYAB/SPTBN1 2 CC GO:0044295 axonal growth cone 2/839 28/19717 0.3358 0.5853 0.4374 TRAK2/FKBP4 2 CC GO:0044298 cell body membrane 2/839 28/19717 0.3358 0.5853 0.4374 ADCY8/THY1 2 CC GO:0005881 cytoplasmic microtubule 4/839 69/19717 0.3381 0.5876 0.4392 MTUS2/MAPRE3/CLIP1/KIF2C 4 CC GO:0035579 specific granule membrane 5/839 91/19717 0.3456 0.5951 0.4447 ATP8A1/ITGB2/BST1/ATP6V1D/PTPRB 5 CC GO:0000164 protein phosphatase type 1 complex 1/839 10/19717 0.3527 0.5951 0.4447 NCK1 1 CC GO:0000813 ESCRT I complex 1/839 10/19717 0.3527 0.5951 0.4447 TSG101 1 CC GO:0000815 ESCRT III complex 1/839 10/19717 0.3527 0.5951 0.4447 CHMP2A 1 CC GO:0016461 unconventional myosin complex 1/839 10/19717 0.3527 0.5951 0.4447 MYO5A 1 CC GO:0031010 ISWI-type complex 1/839 10/19717 0.3527 0.5951 0.4447 SMARCA1 1 CC GO:0031080 nuclear pore outer ring 1/839 10/19717 0.3527 0.5951 0.4447 SEC13 1 CC GO:0035253 ciliary rootlet 1/839 10/19717 0.3527 0.5951 0.4447 RAB28 1 CC GO:0036128 CatSper complex 1/839 10/19717 0.3527 0.5951 0.4447 HSPA2 1 CC GO:0036513 Derlin-1 retrotranslocation complex 1/839 10/19717 0.3527 0.5951 0.4447 SEL1L 1 CC GO:0070938 contractile ring 1/839 10/19717 0.3527 0.5951 0.4447 MYH9 1 CC GO:0032580 Golgi cisterna membrane 5/839 92/19717 0.3541 0.5958 0.4453 CHSY1/B4GALT2/ST6GAL1/INPP5E/TMED2 5 CC GO:0060076 excitatory synapse 3/839 50/19717 0.3586 0.6001 0.4485 ADCY8/PDE4B/ITGA3 3 CC GO:0071005 U2-type precatalytic spliceosome 3/839 50/19717 0.3586 0.6001 0.4485 WBP4/LSM4/IK 3 CC GO:0044445 cytosolic part 12/839 247/19717 0.3608 0.6023 0.4501 PI4K2A/SH3GL2/PIN1/HPS1/PSMD1/CIAO1/PRKCB/MTOR/RRM2/CCT7/CASP9/PSMD2 12 CC GO:0005776 autophagosome 5/839 93/19717 0.3626 0.6037 0.4511 CLN3/PRKD1/PIK3C3/VPS11/MAP1LC3B 5 CC GO:0008328 ionotropic glutamate receptor complex 3/839 51/19717 0.3703 0.6116 0.4571 EPS8/GRIN2B/GRIN2A 3 CC GO:0043195 terminal bouton 3/839 51/19717 0.3703 0.6116 0.4571 BLVRB/NTRK2/UNC13B 3 CC GO:0071011 precatalytic spliceosome 3/839 51/19717 0.3703 0.6116 0.4571 WBP4/LSM4/IK 3 CC GO:0044306 neuron projection terminus 7/839 138/19717 0.3726 0.6121 0.4575 ATP6V0D1/BLVRB/NTRK2/KIAA1107/PRKCB/UNC13B/ITGA2 7 CC GO:0070821 tertiary granule membrane 4/839 73/19717 0.3771 0.6121 0.4575 ITGB2/ATP6V0C/SERPINB6/PTPRB 4 CC GO:0000235 astral microtubule 1/839 11/19717 0.3803 0.6121 0.4575 MAPRE3 1 CC GO:0005818 aster 1/839 11/19717 0.3803 0.6121 0.4575 MAPRE3 1 CC GO:0005832 chaperonin-containing T-complex 1/839 11/19717 0.3803 0.6121 0.4575 CCT7 1 CC GO:0005885 Arp2/3 protein complex 1/839 11/19717 0.3803 0.6121 0.4575 ARPC1B 1 CC GO:0031680 G-protein beta/gamma-subunit complex 1/839 11/19717 0.3803 0.6121 0.4575 GNG12 1 CC GO:0031932 TORC2 complex 1/839 11/19717 0.3803 0.6121 0.4575 MTOR 1 CC GO:0045240 dihydrolipoyl dehydrogenase complex 1/839 11/19717 0.3803 0.6121 0.4575 OGDH 1 CC GO:0072687 meiotic spindle 1/839 11/19717 0.3803 0.6121 0.4575 HSPA2 1 CC GO:0098878 neurotransmitter receptor complex 3/839 53/19717 0.3936 0.6205 0.4637 EPS8/GRIN2B/GRIN2A 3 CC GO:0043679 axon terminus 6/839 119/19717 0.3954 0.6205 0.4637 ATP6V0D1/BLVRB/NTRK2/PRKCB/UNC13B/ITGA2 6 CC GO:0000407 phagophore assembly site 2/839 32/19717 0.3977 0.6205 0.4637 ATG2A/PIK3C3 2 CC GO:0005921 gap junction 2/839 32/19717 0.3977 0.6205 0.4637 GJA1/GJC1 2 CC GO:0000109 nucleotide-excision repair complex 1/839 12/19717 0.4066 0.6205 0.4637 XPC 1 CC GO:0000812 Swr1 complex 1/839 12/19717 0.4066 0.6205 0.4637 ANP32E 1 CC GO:0005845 mRNA cap binding complex 1/839 12/19717 0.4066 0.6205 0.4637 ZFP36 1 CC GO:0005890 sodium:potassium-exchanging ATPase complex 1/839 12/19717 0.4066 0.6205 0.4637 ATP1B1 1 CC GO:0017119 Golgi transport complex 1/839 12/19717 0.4066 0.6205 0.4637 COG4 1 CC GO:0032009 early phagosome 1/839 12/19717 0.4066 0.6205 0.4637 UNC13B 1 CC GO:0032585 multivesicular body membrane 1/839 12/19717 0.4066 0.6205 0.4637 RAB27B 1 CC GO:0034709 methylosome 1/839 12/19717 0.4066 0.6205 0.4637 PRMT1 1 CC GO:0044615 nuclear pore nuclear basket 1/839 12/19717 0.4066 0.6205 0.4637 NUP153 1 CC GO:0048188 Set1C/COMPASS complex 1/839 12/19717 0.4066 0.6205 0.4637 SETD1B 1 CC GO:0061700 GATOR2 complex 1/839 12/19717 0.4066 0.6205 0.4637 SEC13 1 CC GO:0071564 npBAF complex 1/839 12/19717 0.4066 0.6205 0.4637 SMARCE1 1 CC GO:0097449 astrocyte projection 1/839 12/19717 0.4066 0.6205 0.4637 EZR 1 CC GO:0097504 Gemini of coiled bodies 1/839 12/19717 0.4066 0.6205 0.4637 HABP4 1 CC GO:0099144 anchored component of synaptic membrane 1/839 12/19717 0.4066 0.6205 0.4637 GPC4 1 CC GO:1990454 L-type voltage-gated calcium channel complex 1/839 12/19717 0.4066 0.6205 0.4637 CACNA1C 1 CC GO:1990909 Wnt signalosome 1/839 12/19717 0.4066 0.6205 0.4637 FZD1 1 CC GO:0005819 spindle 16/839 347/19717 0.4071 0.6205 0.4637 ESPL1/HAUS7/RANGAP1/ACOT13/KLHL21/NSFL1C/HSPA2/MYH9/DIAPH1/DYNC1I1/MAPRE3/CIAO1/NEK7/CKAP5/IK/EML1 16 CC GO:0015030 Cajal body 4/839 77/19717 0.4159 0.6309 0.4715 HABP4/NOLC1/USPL1/NHP2 4 CC GO:0000792 heterochromatin 4/839 78/19717 0.4255 0.6309 0.4715 FOXC1/HMGA1/UBA1/CDKN2A 4 CC GO:0030285 integral component of synaptic vesicle membrane 2/839 34/19717 0.4276 0.6309 0.4715 SV2A/VAMP3 2 CC GO:0031904 endosome lumen 2/839 34/19717 0.4276 0.6309 0.4715 IL12A/JAK2 2 CC GO:0051233 spindle midzone 2/839 34/19717 0.4276 0.6309 0.4715 MAPRE3/EML1 2 CC GO:0070069 cytochrome complex 2/839 34/19717 0.4276 0.6309 0.4715 UQCRQ/UQCRC1 2 CC GO:0000974 Prp19 complex 1/839 13/19717 0.4319 0.6309 0.4715 SYF2 1 CC GO:0005688 U6 snRNP 1/839 13/19717 0.4319 0.6309 0.4715 LSM4 1 CC GO:0005952 cAMP-dependent protein kinase complex 1/839 13/19717 0.4319 0.6309 0.4715 PRKX 1 CC GO:0008250 oligosaccharyltransferase complex 1/839 13/19717 0.4319 0.6309 0.4715 STT3A 1 CC GO:0030130 clathrin coat of trans-Golgi network vesicle 1/839 13/19717 0.4319 0.6309 0.4715 CLTB 1 CC GO:0042405 nuclear inclusion body 1/839 13/19717 0.4319 0.6309 0.4715 NUP153 1 CC GO:0044233 Mitochondria-associated ER Membrane 1/839 13/19717 0.4319 0.6309 0.4715 RAB32 1 CC GO:0044666 MLL3/4 complex 1/839 13/19717 0.4319 0.6309 0.4715 KDM6A 1 CC GO:0071014 post-mRNA release spliceosomal complex 1/839 13/19717 0.4319 0.6309 0.4715 SYF2 1 CC GO:0071203 WASH complex 1/839 13/19717 0.4319 0.6309 0.4715 SNX27 1 CC GO:0098993 anchored component of synaptic vesicle membrane 1/839 13/19717 0.4319 0.6309 0.4715 RAB27B 1 CC GO:1990023 mitotic spindle midzone 1/839 13/19717 0.4319 0.6309 0.4715 EML1 1 CC GO:0000315 organellar large ribosomal subunit 3/839 57/19717 0.4395 0.639 0.4775 MRPL40/NDUFAB1/MRPL28 3 CC GO:0005762 mitochondrial large ribosomal subunit 3/839 57/19717 0.4395 0.639 0.4775 MRPL40/NDUFAB1/MRPL28 3 CC GO:0005767 secondary lysosome 1/839 14/19717 0.4561 0.6506 0.4862 PIK3C3 1 CC GO:0030688 preribosome, small subunit precursor 1/839 14/19717 0.4561 0.6506 0.4862 BYSL 1 CC GO:0031089 platelet dense granule lumen 1/839 14/19717 0.4561 0.6506 0.4862 RARRES2 1 CC GO:0034518 RNA cap binding complex 1/839 14/19717 0.4561 0.6506 0.4862 ZFP36 1 CC GO:0038201 TOR complex 1/839 14/19717 0.4561 0.6506 0.4862 MTOR 1 CC GO:0043218 compact myelin 1/839 14/19717 0.4561 0.6506 0.4862 PMP22 1 CC GO:0045239 tricarboxylic acid cycle enzyme complex 1/839 14/19717 0.4561 0.6506 0.4862 OGDH 1 CC GO:0000421 autophagosome membrane 2/839 36/19717 0.4568 0.6506 0.4862 PRKD1/MAP1LC3B 2 CC GO:0043198 dendritic shaft 2/839 36/19717 0.4568 0.6506 0.4862 LPAR1/MAP1A 2 CC GO:0034703 cation channel complex 10/839 220/19717 0.4614 0.6557 0.49 KCND3/HSPA2/PDE4B/KCNN4/EPS8/GRIN2B/KCNMB1/CACNA1C/TRPC6/GRIN2A 10 CC GO:0031463 Cul3-RING ubiquitin ligase complex 2/839 37/19717 0.471 0.6603 0.4935 KLHL21/ENC1 2 CC GO:0034358 plasma lipoprotein particle 2/839 37/19717 0.471 0.6603 0.4935 PLTP/VLDLR 2 CC GO:1990777 lipoprotein particle 2/839 37/19717 0.471 0.6603 0.4935 PLTP/VLDLR 2 CC GO:0001673 male germ cell nucleus 1/839 15/19717 0.4793 0.6603 0.4935 HSPA2 1 CC GO:0005639 integral component of nuclear inner membrane 1/839 15/19717 0.4793 0.6603 0.4935 LBR 1 CC GO:0005662 DNA replication factor A complex 1/839 15/19717 0.4793 0.6603 0.4935 RPA3 1 CC GO:0012510 trans-Golgi network transport vesicle membrane 1/839 15/19717 0.4793 0.6603 0.4935 CLTB 1 CC GO:0030126 COPI vesicle coat 1/839 15/19717 0.4793 0.6603 0.4935 ARFGAP2 1 CC GO:0031083 BLOC-1 complex 1/839 15/19717 0.4793 0.6603 0.4935 PI4K2A 1 CC GO:0031229 intrinsic component of nuclear inner membrane 1/839 15/19717 0.4793 0.6603 0.4935 LBR 1 CC GO:0031616 spindle pole centrosome 1/839 15/19717 0.4793 0.6603 0.4935 NSFL1C 1 CC GO:0033290 eukaryotic 48S preinitiation complex 1/839 15/19717 0.4793 0.6603 0.4935 EIF3I 1 CC GO:0071565 nBAF complex 1/839 15/19717 0.4793 0.6603 0.4935 SMARCE1 1 CC GO:0090533 cation-transporting ATPase complex 1/839 15/19717 0.4793 0.6603 0.4935 ATP1B1 1 MF GO:0005201 extracellular matrix structural constituent 42/816 163/17697 2.379e-20 2.112e-17 1.855e-17 PRG4/COL8A1/BGN/COL5A2/COL3A1/EDIL3/COL16A1/IGFBP7/COL1A2/NID2/NID1/THBS1/SPARC/LTBP1/MXRA5/COL11A1/PXDN/EMILIN1/POSTN/COL1A1/COMP/FMOD/LAMB1/ELN/COL14A1/HSPG2/LTBP2/HAPLN1/FBN2/COL6A3/EFEMP1/COL7A1/COL15A1/COL4A1/LAMA1/SPON1/FBLN5/TNC/ACAN/CHI3L1/COL4A2/VCAN 42 MF GO:0005178 integrin binding 24/816 132/17697 7.307e-09 3.042e-06 2.672e-06 COL3A1/EDIL3/ACTN1/COL16A1/THBS4/THBS1/CD151/PRKCA/CXCL12/EMILIN1/ISG15/COMP/LAMB1/ADAM15/ITGB2/MYH9/FAP/ITGB3/ITGA3/THY1/ITGB1BP1/FBLN5/ITGA2/ITGB1 24 MF GO:0050839 cell adhesion molecule binding 53/816 499/17697 1.322e-08 3.042e-06 2.672e-06 COL3A1/EDIL3/ACTN1/CDH11/COL16A1/THBS4/THBS1/CD151/RANGAP1/PRKCA/CXCL12/EMILIN1/PDLIM1/POSTN/ISG15/COMP/LAMB1/CLIC1/HSPA5/ADAM15/ITGB2/CDC42EP1/TRIM25/LDHA/MYH9/LRRFIP1/IQGAP1/EXOC3/FAP/CD2AP/ITGB3/ITGA3/PSMB6/TWF2/FSCN1/FLNB/THY1/NOTCH3/ITGB1BP1/ITGA6/CTNNAL1/FBLN5/ITGA2/NUDC/KRT18/SPTBN1/PTPN11/CKAP5/SLC9A3R2/EZR/PTPRB/NCK1/ITGB1 53 MF GO:0019838 growth factor binding 24/816 137/17697 1.562e-08 3.042e-06 2.672e-06 COL3A1/KAZALD1/IGFBP7/COL1A2/THBS1/LTBP1/PXDN/COL1A1/NTRK2/TGFBR1/IGFBP1/LTBP2/GHR/NRP1/HAX1/S100A13/OSMR/ITGB3/IGFBP6/PDGFA/COL4A1/ITGA6/IL6ST/NRP2 24 MF GO:0019955 cytokine binding 23/816 128/17697 1.891e-08 3.042e-06 2.672e-06 GREM1/CRLF1/IL18R1/THBS1/LTBP1/PXDN/CCRL2/COMP/TGFBR1/IL12A/TNFRSF14/GHR/NRP1/CCR3/HAX1/OSMR/ITGB3/CCR1/IL13RA2/ZFP36/IL6ST/NRP2/ITGB1 23 MF GO:0030020 extracellular matrix structural constituent conferring tensile strength 13/816 41/17697 2.056e-08 3.042e-06 2.672e-06 COL8A1/COL5A2/COL3A1/COL16A1/COL1A2/COL11A1/COL1A1/COL14A1/COL6A3/COL7A1/COL15A1/COL4A1/COL4A2 13 MF GO:0005518 collagen binding 16/816 67/17697 4.456e-08 5.652e-06 4.965e-06 NID2/NID1/THBS1/SPARC/ITGA1/SERPINH1/COMP/COL14A1/SPARCL1/ITGA3/PPIB/MRC2/PDGFA/DDR2/ITGA2/ITGB1 16 MF GO:0003779 actin binding 45/816 431/17697 2.745e-07 3.047e-05 2.676e-05 ACTN1/MTSS1/HIP1R/MICAL2/TPM2/ADCY8/MARCKSL1/PDLIM1/TAGLN/STK38L/PALLD/MYO10/ENC1/TPM1/MYH9/SNTA1/MYLK/MYRIP/TMOD1/CAPZA2/MYO5A/DIAPH1/SMTN/FLII/ARPC1B/GSN/TWF2/FSCN1/EPS8/FLNB/ABLIM1/EPB41L1/CTNNAL1/CNN1/BIN1/SPTBN1/MAP1A/TRPC6/PDLIM7/PAWR/PHACTR4/EZR/GMFG/LMOD1/ITGB1 45 MF GO:0046961 proton-transporting ATPase activity, rotational mechanism 8/816 22/17697 3.546e-06 0.0003498 0.0003073 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 MF GO:0036442 proton-exporting ATPase activity 9/816 30/17697 5.376e-06 0.0004774 0.0004194 ATP6V0E2/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 9 MF GO:0050840 extracellular matrix binding 12/816 57/17697 8.87e-06 0.000716 0.000629 BGN/NID1/THBS1/SPARC/COL11A1/ELN/SPARCL1/ITGB3/ITGA3/ITGA6/ITGA2/ITGB1 12 MF GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/816 22/17697 4.007e-05 0.002916 0.002561 PRG4/BGN/FMOD/HSPG2/HAPLN1/ACAN/VCAN 7 MF GO:0019902 phosphatase binding 22/816 185/17697 4.484e-05 0.002916 0.002561 MAPK3/CTSC/ADCY8/ITGA1/PIK3R1/IQGAP1/MAP3K5/MET/KCNN4/PIK3R2/MAST2/ANKLE2/STAT3/BAD/BCL2/ENSA/FBXL2/CSRNP2/SH3YL1/STRN3/SLC9A3R2/PHACTR4 22 MF GO:0022853 active ion transmembrane transporter activity 12/816 67/17697 4.925e-05 0.002916 0.002561 ATP6V0E2/ATP8A1/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D 12 MF GO:0042625 ATPase coupled ion transmembrane transporter activity 12/816 67/17697 4.925e-05 0.002916 0.002561 ATP6V0E2/ATP8A1/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D 12 MF GO:0042626 ATPase activity, coupled to transmembrane movement of substances 16/816 115/17697 7.512e-05 0.003719 0.003267 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D/TAP1/ABCC10 16 MF GO:0043492 ATPase activity, coupled to movement of substances 16/816 115/17697 7.512e-05 0.003719 0.003267 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D/TAP1/ABCC10 16 MF GO:0048407 platelet-derived growth factor binding 5/816 11/17697 7.539e-05 0.003719 0.003267 COL3A1/COL1A2/COL1A1/PDGFA/COL4A1 5 MF GO:0042277 peptide binding 29/816 295/17697 0.0001062 0.004961 0.004358 SLC7A8/PCSK5/CRYAB/CEMIP/KDELR3/CLTB/RAMP2/EPHB2/MAML1/PIK3R1/ITGB2/HSPG2/GHR/ITM2B/NOLC1/PPIB/NUP153/TGFB2/PEX7/GRIN2B/HLA-DQB1/RPS6KB2/AP2B1/ITGA2/GPR1/TAP1/GRIN2A/KPNA3/HLA-DPB1 29 MF GO:0033218 amide binding 33/816 356/17697 0.0001143 0.005077 0.004459 SLC7A8/PCSK5/CRYAB/CEMIP/KDELR3/CLTB/RAMP2/EPHB2/HMGCL/MAML1/FOLR3/FOLR2/PIK3R1/ITGB2/HSPG2/GHR/ITM2B/PLTP/NOLC1/PPIB/NUP153/TGFB2/PEX7/GRIN2B/HLA-DQB1/RPS6KB2/AP2B1/ITGA2/GPR1/TAP1/GRIN2A/KPNA3/HLA-DPB1 33 MF GO:0017154 semaphorin receptor activity 5/816 12/17697 0.0001243 0.005257 0.004618 PLXND1/NRP1/MET/PLXNC1/NRP2 5 MF GO:0005516 calmodulin binding 22/816 200/17697 0.0001438 0.005804 0.005098 MAPKAPK3/ADCY8/MARCKSL1/GAP43/MYO10/MYH9/SNTA1/IQGAP1/MYLK/SPA17/MYO5A/KCNN4/RGS2/UNC13B/CAMSAP2/PLCB1/CACNA1C/FBXL2/CNN1/STRN3/SPTBN1/CAMK1 22 MF GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 6/816 19/17697 0.0001527 0.005894 0.005177 PYCR1/MTHFD2/BLVRB/QDPR/MTHFD1/CRYM 6 MF GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 16/816 123/17697 0.0001685 0.006057 0.00532 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D/TAP1/ABCC10 16 MF GO:0001968 fibronectin binding 7/816 27/17697 0.0001705 0.006057 0.00532 THBS1/MYOC/ITGB3/ITGA3/IGFBP6/SDC4/ITGB1 7 MF GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 8/816 36/17697 0.000189 0.006235 0.005477 ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D 8 MF GO:0016779 nucleotidyltransferase activity 17/816 137/17697 0.000191 0.006235 0.005477 POLR2L/POLR2E/PCYT2/OAS1/PRIM2/OAS2/POLE3/POLR3D/CDS1/CDS2/POLR3G/TERF2/PRIM1/COASY/FLAD1/POLD2/POLRMT 17 MF GO:0019829 cation-transporting ATPase activity 11/816 66/17697 0.0001971 0.006235 0.005477 ATP6V0E2/ATP8A1/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ATP1B1/TCIRG1/ATP6V1D 11 MF GO:0015399 primary active transmembrane transporter activity 16/816 125/17697 0.0002036 0.006235 0.005477 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/ABCC4/ATP1B1/TCIRG1/ATP6V1D/TAP1/ABCC10 16 MF GO:0019199 transmembrane receptor protein kinase activity 12/816 79/17697 0.0002535 0.007444 0.006539 LTBP1/EPHB2/NTRK2/TGFBR1/EPHB4/NRP1/MET/EFEMP1/DDR2/ROR2/EPHB6/NRP2 12 MF GO:0060090 molecular adaptor activity 24/816 237/17697 0.0002614 0.007444 0.006539 COL1A2/STAM/HIP1R/COL11A1/PIK3R1/COL14A1/SASH1/IQGAP1/LAMTOR5/VPS11/FKBP4/CHN1/FSCN1/EPS8/GRB10/CAV3/ARRB2/GAS6/AP2B1/MAP1A/PTPN11/SLC9A3R2/NCK1/SORBS2 24 MF GO:0002020 protease binding 16/816 128/17697 0.0002683 0.007444 0.006539 COL3A1/COL1A2/COL1A1/RAD23A/COMP/CHL1/CD70/FAP/ITGB3/ITGA3/NDUFS7/SERPINB6/BCL2/BIN1/SH3PXD2A/ITGB1 16 MF GO:0008022 protein C-terminus binding 20/816 187/17697 0.0004104 0.01104 0.009701 SH3GL2/ITGB3BP/HSPG2/SASH1/CIB1/XRCC6/CD2AP/MAPRE3/BANF1/CAV3/ATP1B1/CNGA3/LAMA1/JAK2/TERF2/FBLN5/PHB/SLC9A3R2/EZR/KPNA3 20 MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/816 62/17697 0.0005008 0.01308 0.01149 EPHB2/NTRK2/EPHB4/NRP1/MET/EFEMP1/DDR2/ROR2/EPHB6/NRP2 10 MF GO:0045296 cadherin binding 29/816 331/17697 0.0007292 0.01814 0.01593 CDH11/RANGAP1/PDLIM1/CLIC1/HSPA5/CDC42EP1/TRIM25/LDHA/MYH9/LRRFIP1/IQGAP1/EXOC3/CD2AP/PSMB6/TWF2/FSCN1/FLNB/NOTCH3/ITGA6/CTNNAL1/NUDC/KRT18/SPTBN1/CKAP5/SLC9A3R2/EZR/PTPRB/NCK1/ITGB1 29 MF GO:0019903 protein phosphatase binding 16/816 140/17697 0.0007354 0.01814 0.01593 ADCY8/ITGA1/PIK3R1/IQGAP1/MAP3K5/MET/KCNN4/PIK3R2/ANKLE2/STAT3/BAD/BCL2/ENSA/FBXL2/STRN3/PHACTR4 16 MF GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/816 17/17697 0.0008011 0.01923 0.01689 PIK3R1/PIK3R2/KLF4/SOCS5/SOCS3 5 MF GO:0003954 NADH dehydrogenase activity 8/816 46/17697 0.001085 0.02408 0.02115 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 8/816 46/17697 0.001085 0.02408 0.02115 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 MF GO:0050136 NADH dehydrogenase (quinone) activity 8/816 46/17697 0.001085 0.02408 0.02115 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 MF GO:0043560 insulin receptor substrate binding 4/816 11/17697 0.001141 0.02413 0.0212 PIK3R1/PIK3CB/JAK2/PTPN11 4 MF GO:0097493 structural molecule activity conferring elasticity 4/816 11/17697 0.001141 0.02413 0.0212 EMILIN1/ELN/FBN2/FBLN5 4 MF GO:0017147 Wnt-protein binding 7/816 37/17697 0.001323 0.02732 0.024 SFRP4/FZD7/FZD2/MET/FZD6/ROR2/FZD1 7 MF GO:0005520 insulin-like growth factor binding 6/816 28/17697 0.001486 0.02933 0.02576 KAZALD1/IGFBP7/IGFBP1/ITGB3/IGFBP6/ITGA6 6 MF GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 6/816 28/17697 0.001486 0.02933 0.02576 PYCR1/MTHFD2/BLVRB/QDPR/MTHFD1/CRYM 6 MF GO:0031994 insulin-like growth factor I binding 4/816 12/17697 0.00165 0.03117 0.02738 IGFBP1/ITGB3/IGFBP6/ITGA6 4 MF GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 4/816 12/17697 0.00165 0.03117 0.02738 SYNJ2/FIG4/INPP5E/PIKFYVE 4 MF GO:0043236 laminin binding 6/816 29/17697 0.001802 0.03333 0.02928 NID1/THBS1/ITGA3/ITGA6/ITGA2/ITGB1 6 MF GO:0051015 actin filament binding 19/816 198/17697 0.002064 0.03741 0.03286 ACTN1/HIP1R/TPM2/TAGLN/MYO10/TPM1/MYH9/TMOD1/CAPZA2/MYO5A/FLII/ARPC1B/GSN/TWF2/FSCN1/ABLIM1/CTNNAL1/BIN1/EZR 19 MF GO:0030674 protein binding, bridging 17/816 170/17697 0.002248 0.03922 0.03445 COL1A2/STAM/HIP1R/COL11A1/PIK3R1/COL14A1/VPS11/FKBP4/CHN1/FSCN1/GRB10/GAS6/AP2B1/MAP1A/PTPN11/NCK1/SORBS2 17 MF GO:0005540 hyaluronic acid binding 5/816 21/17697 0.00226 0.03922 0.03445 CEMIP/HAPLN1/ACAN/VCAN/NCAN 5 MF GO:0005172 vascular endothelial growth factor receptor binding 4/816 13/17697 0.002297 0.03922 0.03445 GREM1/VEGFC/CD2AP/ITGB3 4 MF GO:0050661 NADP binding 8/816 52/17697 0.002454 0.0405 0.03557 TM7SF2/LBR/QDPR/FMO1/FMO3/FMO2/CAT/CRYM 8 MF GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/816 41/17697 0.002463 0.0405 0.03557 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1/POLRMT 7 MF GO:0019956 chemokine binding 6/816 32/17697 0.003056 0.04915 0.04317 CCRL2/CCR3/ITGB3/CCR1/ZFP36/ITGB1 6 MF GO:0046935 1-phosphatidylinositol-3-kinase regulator activity 4/816 14/17697 0.003099 0.04915 0.04317 PIK3R1/PIK3R2/SOCS5/SOCS3 4 MF GO:0030374 nuclear receptor transcription coactivator activity 9/816 67/17697 0.003501 0.05454 0.04791 VDR/ACTN1/NR1H2/NR1H3/PRKCB/TSG101/PPRC1/HMGA1/PKN1 9 MF GO:0003713 transcription coactivator activity 26/816 319/17697 0.00363 0.05488 0.04821 VDR/ACTN1/PCBD1/PDLIM1/MAGED1/MAML1/PHF2/YAF2/FOXC1/NUPR1/KAT2B/NR1H2/WWTR1/NR1H3/WBP2/TFAP2A/PRKCB/TSG101/PPRC1/SMARCE1/PER2/SOX4/HMGA1/PKN1/DYRK1B/CREBBP 26 MF GO:0051117 ATPase binding 10/816 80/17697 0.003646 0.05488 0.04821 ATP6V0A1/ATP6V1E1/ATOX1/NSFL1C/NR1H2/SNTA1/ATP1B1/TCIRG1/TRPC6/EZR 10 MF GO:0015026 coreceptor activity 7/816 44/17697 0.003725 0.05513 0.04843 RAMP2/PTK7/NRP1/GPC4/ITGB3/ROR2/ITGB1 7 MF GO:0051287 NAD binding 8/816 56/17697 0.003941 0.05737 0.05039 IDH2/SORD/LDHA/QDPR/HADH/GPD1L/ALDH2/ALDH1A3 8 MF GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 6/816 34/17697 0.004195 0.05882 0.05167 MTHFD2/APOBEC3B/ADARB1/ADAR/APOBEC3C/MTHFD1 6 MF GO:0034062 5'-3' RNA polymerase activity 7/816 45/17697 0.00424 0.05882 0.05167 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1/POLRMT 7 MF GO:0097747 RNA polymerase activity 7/816 45/17697 0.00424 0.05882 0.05167 POLR2L/POLR2E/PRIM2/POLR3D/POLR3G/PRIM1/POLRMT 7 MF GO:0004896 cytokine receptor activity 11/816 96/17697 0.004642 0.06342 0.05571 CRLF1/IL18R1/CCRL2/IL1RAP/GHR/CCR3/OSMR/CCR1/IL13RA2/IL6ST/IL4R 11 MF GO:0005048 signal sequence binding 7/816 46/17697 0.004806 0.06466 0.0568 CEMIP/KDELR3/NOLC1/NUP153/PEX7/AP2B1/KPNA3 7 MF GO:0004697 protein kinase C activity 4/816 16/17697 0.005236 0.06939 0.06095 PRKCA/PRKD1/PRKCB/PKN1 4 MF GO:0098631 cell adhesion mediator activity 8/816 59/17697 0.005452 0.0712 0.06254 EMILIN1/PDLIM1/ITGA1/PALLD/CDC42EP1/ITGA2/KRT18/ITGB1 8 MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/816 60/17697 0.006043 0.07778 0.06832 NDUFB8/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/NDUFA1/NDUFB7 8 MF GO:0009055 electron transfer activity 12/816 114/17697 0.006324 0.0792 0.06957 SDHA/QDPR/NDUFS6/NDUFS3/LOXL2/COX5B/UQCRQ/SDHB/UQCRC1/COX7A2/ETFB/ALDH2 12 MF GO:0042623 ATPase activity, coupled 23/816 284/17697 0.006463 0.0792 0.06957 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/SMARCA1/HSPA5/RFC3/MYO10/HSPA2/MYH9/ATP6V0C/ATP6V1H/ABCC4/DYNC1I1/ATP1B1/TCIRG1/ATP6V1D/TAP1/ABCC10 23 MF GO:0035173 histone kinase activity 4/816 17/17697 0.0066 0.0792 0.06957 PRKCA/JAK2/PRKCB/PKN1 4 MF GO:0042813 Wnt-activated receptor activity 4/816 17/17697 0.0066 0.0792 0.06957 FZD7/FZD2/FZD6/FZD1 4 MF GO:0051010 microtubule plus-end binding 4/816 17/17697 0.0066 0.0792 0.06957 MAPRE3/CLIP1/KIF2C/CKAP5 4 MF GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/816 18/17697 0.008181 0.09686 0.08508 SASH1/MAP4K2/ROR2/MAP2K4 4 MF GO:0045309 protein phosphorylated amino acid binding 7/816 51/17697 0.008527 0.09964 0.08752 MAPK3/PIN1/PIK3R1/PIK3R2/RASA1/SOCS3/PTPN11 7 MF GO:0004713 protein tyrosine kinase activity 13/816 134/17697 0.009013 0.1039 0.0913 EPHB2/NTRK2/EPHB4/NRP1/MET/EFEMP1/DDR2/JAK2/ROR2/MAP2K4/EPHB6/NRP2/DYRK1B 13 MF GO:0001784 phosphotyrosine residue binding 6/816 40/17697 0.00948 0.1074 0.0943 MAPK3/PIK3R1/PIK3R2/RASA1/SOCS3/PTPN11 6 MF GO:0001540 amyloid-beta binding 9/816 78/17697 0.009551 0.1074 0.0943 CRYAB/EPHB2/ITGB2/HSPG2/ITM2B/TGFB2/GRIN2B/ITGA2/GRIN2A 9 MF GO:0005539 glycosaminoglycan binding 19/816 229/17697 0.009867 0.1095 0.0962 BGN/THBS4/THBS1/CEMIP/COL11A1/POSTN/SOD3/COMP/BMP4/LTBP2/DPYSL3/HAPLN1/NRP1/SULF1/ACAN/ZNF146/NRP2/VCAN/NCAN 19 MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 11/816 107/17697 0.01036 0.1136 0.09979 MICAL2/NDUFB8/TXN/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/GMPR/NDUFA1/NDUFB7 11 MF GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 12/816 123/17697 0.01134 0.1228 0.1079 NACC2/MTHFD2/DDAH2/APOBEC3B/ADARB1/ADAR/APOBEC3C/MTHFD1/ASAH1/NAAA/CAT/BTD 12 MF GO:0042605 peptide antigen binding 5/816 31/17697 0.01291 0.1381 0.1213 SLC7A8/MAML1/HLA-DQB1/TAP1/HLA-DPB1 5 MF GO:0030971 receptor tyrosine kinase binding 8/816 69/17697 0.01377 0.1456 0.1279 MYOC/ANGPT1/PIK3R1/PIK3R2/GAS6/SOCS5/PTPN11/NCK1 8 MF GO:0051219 phosphoprotein binding 9/816 83/17697 0.01407 0.1469 0.1291 MAPK3/PIN1/PIK3R1/FKBP4/PIK3R2/RASA1/SOCS3/MTOR/PTPN11 9 MF GO:0019239 deaminase activity 5/816 32/17697 0.01473 0.1493 0.1311 APOBEC3B/ADARB1/ADAR/APOBEC3C/GNPDA1 5 MF GO:0051721 protein phosphatase 2A binding 5/816 32/17697 0.01473 0.1493 0.1311 ADCY8/ANKLE2/BCL2/ENSA/STRN3 5 MF GO:0005543 phospholipid binding 30/816 427/17697 0.01479 0.1493 0.1311 PLA2G15/PLEKHB2/HIP1R/THBS1/GRAMD1B/ESYT1/ABCG1/FZD7/GAP43/PLA2G4C/NSFL1C/MCF2L/MYO10/IQGAP1/ITPR3/PLTP/TWF2/ANXA3/SNX27/THY1/GAS6/CHMP2A/LPAR1/UNC13B/BAD/PLCB1/BIN1/SH3YL1/SH3PXD2A/SPTBN1 30 MF GO:0019207 kinase regulator activity 17/816 207/17697 0.0155 0.1546 0.1358 GREM1/PIK3R1/KAT2B/CIB1/CCND2/IQGAP1/PIK3R2/CD24/KLF4/GAS6/SOCS5/SOCS3/WNT11/HEXIM1/CDKN2A/GMFG/NCK1 17 MF GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/816 12/17697 0.01572 0.1551 0.1363 KAT2B/HEXIM1/CDKN2A 3 MF GO:0038024 cargo receptor activity 9/816 85/17697 0.01625 0.1586 0.1393 PRG4/ENPP1/HIP1R/FOLR2/ITGB2/LOXL2/AP2B1/ENPP2/VLDLR 9 MF GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 5/816 33/17697 0.01672 0.1614 0.1418 ATP2A2/ATP6V0D1/ATP6V1E1/ABCC4/ATP1B1 5 MF GO:0005158 insulin receptor binding 4/816 22/17697 0.0169 0.1614 0.1418 ENPP1/PIK3R1/GRB10/PTPN11 4 MF GO:0051082 unfolded protein binding 12/816 131/17697 0.01798 0.1699 0.1492 CRYAB/CLN3/SERPINH1/HSPA5/HSPA2/PPIB/TRAP1/DNAJB5/CCT7/NUDC/TTC1/LMAN1 12 MF GO:0042805 actinin binding 6/816 46/17697 0.01835 0.1715 0.1506 PDLIM1/PALLD/CSRP2/CACNA1C/TRPC6/PDLIM7 6 MF GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/816 23/17697 0.01973 0.179 0.1572 SYNJ2/FIG4/INPP5E/PIKFYVE 4 MF GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism 3/816 13/17697 0.01975 0.179 0.1572 ATP2A2/ATP6V0D1/ATP6V1E1 3 MF GO:0043495 protein membrane anchor 3/816 13/17697 0.01975 0.179 0.1572 CIB1/MYH9/NUP153 3 MF GO:0070851 growth factor receptor binding 12/816 134/17697 0.02111 0.1893 0.1663 GREM1/IL1RAP/VEGFC/ARF4/IL12A/CD2AP/ITGB3/EFEMP1/PDGFA/JAK2/SOCS5/IL6ST 12 MF GO:0019957 C-C chemokine binding 4/816 24/17697 0.02284 0.2028 0.1781 CCRL2/CCR3/CCR1/ZFP36 4 MF GO:0043394 proteoglycan binding 5/816 36/17697 0.02373 0.2086 0.1833 NID1/THBS1/COMP/TNC/ITGA2 5 MF GO:0005126 cytokine receptor binding 21/816 286/17697 0.02444 0.2127 0.1869 GREM1/CRLF1/PXDN/CXCL12/CCRL2/IL1RAP/BMP4/TGFBR1/PIK3R1/VEGFC/CD70/IL12A/INHBB/DEFB1/CD2AP/ITGB3/TRAP1/STAT3/TGFB2/JAK2/IL6ST 21 MF GO:0004860 protein kinase inhibitor activity 7/816 63/17697 0.02543 0.2192 0.1926 KAT2B/CIB1/SOCS3/HEXIM1/CDKN2A/GMFG/NCK1 7 MF GO:0001871 pattern binding 4/816 25/17697 0.02622 0.2218 0.1948 PRG4/ENPP1/PTX3/ENPP2 4 MF GO:0030247 polysaccharide binding 4/816 25/17697 0.02622 0.2218 0.1948 PRG4/ENPP1/PTX3/ENPP2 4 MF GO:1990782 protein tyrosine kinase binding 9/816 93/17697 0.02753 0.2286 0.2008 MYOC/ANGPT1/GJA1/PIK3R1/PIK3R2/GAS6/SOCS5/PTPN11/NCK1 9 MF GO:0050662 coenzyme binding 21/816 291/17697 0.02882 0.2286 0.2008 IDH2/TM7SF2/MICAL2/SORD/SDHA/HMGCL/OGDH/LBR/LDHA/QDPR/FMO1/P4HA1/FMO3/HADH/PRMT1/GPD1L/FMO2/ALDH2/ALDH1A3/CAT/CRYM 21 MF GO:0001056 RNA polymerase III activity 3/816 15/17697 0.02935 0.2286 0.2008 POLR2L/POLR2E/POLR3D 3 MF GO:0001846 opsonin binding 3/816 15/17697 0.02935 0.2286 0.2008 ITGB2/PTX3/PHB 3 MF GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/816 15/17697 0.02935 0.2286 0.2008 LPGAT1/ABHD5/AGPAT1 3 MF GO:0004029 aldehyde dehydrogenase (NAD) activity 3/816 15/17697 0.02935 0.2286 0.2008 ALDH2/ALDH1A3/ALDH7A1 3 MF GO:0015929 hexosaminidase activity 3/816 15/17697 0.02935 0.2286 0.2008 CEMIP/NAGLU/GM2A 3 MF GO:0042171 lysophosphatidic acid acyltransferase activity 3/816 15/17697 0.02935 0.2286 0.2008 LPGAT1/ABHD5/AGPAT1 3 MF GO:0044548 S100 protein binding 3/816 15/17697 0.02935 0.2286 0.2008 ATP2A2/IQGAP1/EZR 3 MF GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/816 26/17697 0.02989 0.2288 0.201 TM7SF2/BLVRB/LBR/TECR 4 MF GO:0051019 mitogen-activated protein kinase binding 4/816 26/17697 0.02989 0.2288 0.201 MAPKAPK3/IQGAP1/PRMT1/ARRB2 4 MF GO:0005109 frizzled binding 5/816 39/17697 0.0324 0.2438 0.2141 MYOC/FZD7/WNT11/ROR2/FZD1 5 MF GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 5/816 39/17697 0.0324 0.2438 0.2141 MICAL2/FMO1/FMO3/CYP27A1/FMO2 5 MF GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/816 27/17697 0.03385 0.2441 0.2144 SYNJ2/FIG4/INPP5E/PIKFYVE 4 MF GO:0019210 kinase inhibitor activity 7/816 67/17697 0.0342 0.2441 0.2144 KAT2B/CIB1/SOCS3/HEXIM1/CDKN2A/GMFG/NCK1 7 MF GO:0004708 MAP kinase kinase activity 3/816 16/17697 0.03491 0.2441 0.2144 MAPK3/MAPKAPK3/MAP2K4 3 MF GO:0005521 lamin binding 3/816 16/17697 0.03491 0.2441 0.2144 LBR/IFI27/PLCB1 3 MF GO:0008093 cytoskeletal adaptor activity 3/816 16/17697 0.03491 0.2441 0.2144 MAP1A/NCK1/SORBS2 3 MF GO:0016307 phosphatidylinositol phosphate kinase activity 3/816 16/17697 0.03491 0.2441 0.2144 PIK3CB/PIP5K1A/PIKFYVE 3 MF GO:0050780 dopamine receptor binding 3/816 16/17697 0.03491 0.2441 0.2144 PALM/ARRB2/PTPN11 3 MF GO:0052742 phosphatidylinositol kinase activity 3/816 16/17697 0.03491 0.2441 0.2144 PI4K2A/PIK3C3/PIK3CB 3 MF GO:0071617 lysophospholipid acyltransferase activity 3/816 16/17697 0.03491 0.2441 0.2144 LPGAT1/ABHD5/AGPAT1 3 MF GO:0008083 growth factor activity 13/816 163/17697 0.03867 0.2674 0.2348 THBS4/BMP1/CXCL12/GRN/BMP4/VEGFC/IL12A/INHBB/EFEMP1/PDGFA/TGFB2/MIA/GMFG 13 MF GO:0004497 monooxygenase activity 9/816 99/17697 0.03899 0.2674 0.2348 MICAL2/CYP1B1/PCBD1/FMO1/FMO3/CYP3A4/CYP27A1/TYR/FMO2 9 MF GO:0051539 4 iron, 4 sulfur cluster binding 5/816 41/17697 0.03914 0.2674 0.2348 ACO2/PRIM2/NDUFS7/SDHB/RSAD2 5 MF GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/816 17/17697 0.04098 0.2736 0.2403 PTPRA/PTPRK/PTPRB 3 MF GO:0005005 transmembrane-ephrin receptor activity 3/816 17/17697 0.04098 0.2736 0.2403 EPHB2/EPHB4/EPHB6 3 MF GO:0019198 transmembrane receptor protein phosphatase activity 3/816 17/17697 0.04098 0.2736 0.2403 PTPRA/PTPRK/PTPRB 3 MF GO:0070566 adenylyltransferase activity 4/816 29/17697 0.04264 0.2826 0.2482 OAS1/OAS2/COASY/FLAD1 4 MF GO:0030695 GTPase regulator activity 21/816 304/17697 0.04297 0.2827 0.2483 RANGAP1/TBC1D4/RUNDC3A/ABR/IQGAP1/NRP1/GNB5/CHN1/ARL2/THY1/ARHGEF15/RASA1/ITGB1BP1/RGS2/ARFGAP2/WNT11/PLCB1/HTR2B/RABGAP1L/SEC23B/AGFG1 21 MF GO:0015078 proton transmembrane transporter activity 11/816 133/17697 0.04365 0.285 0.2503 ATP6V0E2/ATP6V0A1/ATP2A2/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/COX5B/COX7A2/TCIRG1/ATP6V1D 11 MF GO:0016209 antioxidant activity 8/816 86/17697 0.04457 0.2889 0.2538 GSTO1/CLIC2/PXDN/TXN/SOD3/GPX4/GPX3/CAT 8 MF GO:0051087 chaperone binding 9/816 102/17697 0.04578 0.2932 0.2575 CTSC/GRN/TBCE/HSPA5/HSPA2/GNB5/DNAJB5/BAG1/BIN1 9 MF GO:0030276 clathrin binding 6/816 57/17697 0.04666 0.2932 0.2575 HIP1R/CEMIP/CLTB/AP2B1/BIN1/TRPC6 6 MF GO:0043548 phosphatidylinositol 3-kinase binding 4/816 30/17697 0.04747 0.2932 0.2575 PIK3R1/PIK3IP1/JAK2/FBXL2 4 MF GO:0051427 hormone receptor binding 14/816 185/17697 0.04752 0.2932 0.2575 VDR/TCF7L2/TACC2/FKBP4/WBP2/HIF1A/STAT3/JAK2/OASL/PRKCB/PTPN11/SMARCE1/HMGA1/PKN1 14 MF GO:0016755 transferase activity, transferring amino-acyl groups 3/816 18/17697 0.04754 0.2932 0.2575 GGT5/TGM2/TGM4 3 MF GO:0022804 active transmembrane transporter activity 24/816 362/17697 0.04799 0.2932 0.2575 SLC35D2/ATP6V0E2/ATP8A1/SLC4A4/ABCA3/ATP6V0A1/ABCG1/ATP2A2/SLC20A1/ATP6V0D1/ATP6V1E1/SLC1A5/SLC4A3/CLCN7/ATP6V0C/ATP6V1H/SLC25A16/ABCC4/ATP1B1/TCIRG1/CLCN6/ATP6V1D/TAP1/ABCC10 24 MF GO:0031625 ubiquitin protein ligase binding 20/816 290/17697 0.04803 0.2932 0.2575 SCAMP3/RANGAP1/PSMD1/HSPA5/UBOX5/UBE2G1/TNFRSF14/ATP6V0C/CKB/HIF1A/FZD6/UBE2J1/ARRB2/UQCRC1/TSG101/BAG1/BCL2/NEDD8/MAP1LC3B/TPI1 20 MF GO:0060589 nucleoside-triphosphatase regulator activity 23/816 344/17697 0.04817 0.2932 0.2575 RANGAP1/TBC1D4/RUNDC3A/ABR/IQGAP1/NRP1/GNB5/CHN1/ARL2/THY1/ARHGEF15/ATP1B1/RASA1/ITGB1BP1/RGS2/ARFGAP2/WNT11/BAG1/PLCB1/HTR2B/RABGAP1L/SEC23B/AGFG1 23 MF GO:0044389 ubiquitin-like protein ligase binding 21/816 308/17697 0.04821 0.2932 0.2575 STAM/SCAMP3/RANGAP1/PSMD1/HSPA5/UBOX5/UBE2G1/TNFRSF14/ATP6V0C/CKB/HIF1A/FZD6/UBE2J1/ARRB2/UQCRC1/TSG101/BAG1/BCL2/NEDD8/MAP1LC3B/TPI1 21 MF GO:0035257 nuclear hormone receptor binding 12/816 152/17697 0.04875 0.2945 0.2587 VDR/TCF7L2/TACC2/FKBP4/WBP2/HIF1A/STAT3/OASL/PRKCB/SMARCE1/HMGA1/PKN1 12 MF GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/816 58/17697 0.0501 0.3006 0.264 TM7SF2/SDHA/BLVRB/LBR/SDHB/TECR 6 MF GO:0016887 ATPase activity 25/816 384/17697 0.05274 0.3127 0.2746 ATP6V0E2/ATP8A1/ABCA3/ATP6V0A1/ABCG1/ATP2A2/ATP6V0D1/ATP6V1E1/SMARCA1/HSPA5/RFC3/MYO10/HSPA2/MYH9/ATP6V0C/ATP6V1H/ABCC4/DDX39A/DYNC1I1/ATP1B1/TCIRG1/ATP6V1D/KIF2C/TAP1/ABCC10 25 MF GO:0005507 copper ion binding 6/816 59/17697 0.05369 0.3127 0.2746 SOD3/ATOX1/LOX/S100A13/TYR/LOXL2 6 MF GO:0019003 GDP binding 7/816 74/17697 0.05394 0.3127 0.2746 DIRAS3/RRAGD/RAB27B/ARL2/RAB8A/RAB29/RAB28 7 MF GO:0004622 lysophospholipase activity 3/816 19/17697 0.05458 0.3127 0.2746 PLA2G15/PLA2G4C/ENPP2 3 MF GO:0005003 ephrin receptor activity 3/816 19/17697 0.05458 0.3127 0.2746 EPHB2/EPHB4/EPHB6 3 MF GO:0030296 protein tyrosine kinase activator activity 3/816 19/17697 0.05458 0.3127 0.2746 GREM1/CD24/GAS6 3 MF GO:0098641 cadherin binding involved in cell-cell adhesion 3/816 19/17697 0.05458 0.3127 0.2746 PDLIM1/CDC42EP1/KRT18 3 MF GO:0048156 tau protein binding 5/816 45/17697 0.05502 0.3132 0.2751 PIN1/HSPA2/FKBP4/BIN1/MAP1A 5 MF GO:0003725 double-stranded RNA binding 7/816 75/17697 0.05724 0.3197 0.2808 ACTN1/OAS1/ADARB1/OAS2/ADAR/LRRFIP1/OASL 7 MF GO:0005254 chloride channel activity 7/816 75/17697 0.05724 0.3197 0.2808 CLIC2/CLIC1/CLDN4/CLCN7/GLRB/CLCN6/CLIC5 7 MF GO:0016835 carbon-oxygen lyase activity 7/816 75/17697 0.05724 0.3197 0.2808 ECI1/ACO2/PCBD1/AUH/XRCC6/UROS/TPI1 7 MF GO:0030291 protein serine/threonine kinase inhibitor activity 4/816 32/17697 0.058 0.3219 0.2828 KAT2B/CIB1/HEXIM1/CDKN2A 4 MF GO:0008307 structural constituent of muscle 5/816 46/17697 0.05949 0.3281 0.2882 TPM2/TPM1/CSRP2/SMTN/SORBS2 5 MF GO:0044325 ion channel binding 10/816 124/17697 0.06062 0.3323 0.2919 ACTN1/KCND3/CIB1/SNTA1/PDE4B/DIAPH1/CAV3/STAC/USP10/GPD1L 10 MF GO:0004745 retinol dehydrogenase activity 3/816 20/17697 0.06208 0.3361 0.2953 ADH1C/ADH1A/ADH1B 3 MF GO:0008373 sialyltransferase activity 3/816 20/17697 0.06208 0.3361 0.2953 ST3GAL5/ST6GALNAC2/ST6GAL1 3 MF GO:0015631 tubulin binding 22/816 336/17697 0.06283 0.3367 0.2957 CRYAB/VPS41/HAUS7/TBCE/GJA1/MTUS2/PDE4B/DYNC1I1/MAST2/MAPRE3/CAV3/RGS2/CLIP1/CAMSAP2/MAP1A/KIF2C/MAP1LC3B/CKAP5/EML1/MX1/EZR/MX2 22 MF GO:0031406 carboxylic acid binding 14/816 193/17697 0.0632 0.3367 0.2957 VDR/CEMIP/HMGCL/DDAH2/FOLR3/FOLR2/NDUFAB1/P4HA1/HAPLN1/GLRB/GRIN2B/ACAN/VCAN/NCAN 14 MF GO:0008017 microtubule binding 17/816 246/17697 0.06351 0.3367 0.2957 CRYAB/VPS41/HAUS7/MTUS2/DYNC1I1/MAST2/MAPRE3/CLIP1/CAMSAP2/MAP1A/KIF2C/MAP1LC3B/CKAP5/EML1/MX1/EZR/MX2 17 MF GO:0097718 disordered domain specific binding 4/816 33/17697 0.0637 0.3367 0.2957 GJA1/HSPA2/MYO5A/EZR 4 MF GO:0051536 iron-sulfur cluster binding 6/816 63/17697 0.06961 0.3512 0.3085 ACO2/PRIM2/ISCA1/NDUFS7/SDHB/RSAD2 6 MF GO:0051540 metal cluster binding 6/816 63/17697 0.06961 0.3512 0.3085 ACO2/PRIM2/ISCA1/NDUFS7/SDHB/RSAD2 6 MF GO:0001848 complement binding 3/816 21/17697 0.07004 0.3512 0.3085 ITGB2/PTX3/PHB 3 MF GO:0004298 threonine-type endopeptidase activity 3/816 21/17697 0.07004 0.3512 0.3085 PSMB7/PSMB6/PSMB8 3 MF GO:0004602 glutathione peroxidase activity 3/816 21/17697 0.07004 0.3512 0.3085 CLIC2/GPX4/GPX3 3 MF GO:0016411 acylglycerol O-acyltransferase activity 3/816 21/17697 0.07004 0.3512 0.3085 LPGAT1/ABHD5/AGPAT1 3 MF GO:0051861 glycolipid binding 3/816 21/17697 0.07004 0.3512 0.3085 HSPA2/THY1/LAMA1 3 MF GO:0070003 threonine-type peptidase activity 3/816 21/17697 0.07004 0.3512 0.3085 PSMB7/PSMB6/PSMB8 3 MF GO:1901681 sulfur compound binding 17/816 250/17697 0.07141 0.3512 0.3085 ENPP1/THBS4/THBS1/COL11A1/POSTN/HMGCL/SOD3/COMP/BMP4/OGDH/LTBP2/DPYSL3/NRP1/PRMT1/ITGA2/ZNF146/NRP2 17 MF GO:0019887 protein kinase regulator activity 13/816 180/17697 0.07345 0.3512 0.3085 GREM1/KAT2B/CIB1/CCND2/IQGAP1/CD24/GAS6/SOCS3/WNT11/HEXIM1/CDKN2A/GMFG/NCK1 13 MF GO:0004016 adenylate cyclase activity 2/816 10/17697 0.07475 0.3512 0.3085 ADCY8/ADCY7 2 MF GO:0008121 ubiquinol-cytochrome-c reductase activity 2/816 10/17697 0.07475 0.3512 0.3085 UQCRQ/UQCRC1 2 MF GO:0016303 1-phosphatidylinositol-3-kinase activity 2/816 10/17697 0.07475 0.3512 0.3085 PIK3C3/PIK3CB 2 MF GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 2/816 10/17697 0.07475 0.3512 0.3085 UQCRQ/UQCRC1 2 MF GO:0035615 clathrin adaptor activity 2/816 10/17697 0.07475 0.3512 0.3085 HIP1R/AP2B1 2 MF GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/816 10/17697 0.07475 0.3512 0.3085 PIK3R1/FBXL2 2 MF GO:0046790 virion binding 2/816 10/17697 0.07475 0.3512 0.3085 TSG101/PTX3 2 MF GO:0051400 BH domain binding 2/816 10/17697 0.07475 0.3512 0.3085 BCL2L1/BCL2 2 MF GO:0070016 armadillo repeat domain binding 2/816 10/17697 0.07475 0.3512 0.3085 TCF7L2/STRN3 2 MF GO:0070513 death domain binding 2/816 10/17697 0.07475 0.3512 0.3085 BCL2L1/BCL2 2 MF GO:0098748 endocytic adaptor activity 2/816 10/17697 0.07475 0.3512 0.3085 HIP1R/AP2B1 2 MF GO:0035591 signaling adaptor activity 7/816 80/17697 0.07558 0.3533 0.3103 STAM/PIK3R1/CHN1/EPS8/GRB10/PTPN11/NCK1 7 MF GO:0017124 SH3 domain binding 10/816 130/17697 0.07791 0.3571 0.3137 SYNJ2/HIP1R/ADAM12/GJA1/ADAM15/DPYSL3/CD2AP/RAPGEF1/ADAM19/CASP9 10 MF GO:0000146 microfilament motor activity 3/816 22/17697 0.07843 0.3571 0.3137 MYO10/MYH9/MYO5A 3 MF GO:0009975 cyclase activity 3/816 22/17697 0.07843 0.3571 0.3137 ADCY8/ADCY7/BST1 3 MF GO:0016849 phosphorus-oxygen lyase activity 3/816 22/17697 0.07843 0.3571 0.3137 ADCY8/ADCY7/BST1 3 MF GO:0050431 transforming growth factor beta binding 3/816 22/17697 0.07843 0.3571 0.3137 THBS1/LTBP1/TGFBR1 3 MF GO:0005096 GTPase activator activity 18/816 273/17697 0.08171 0.3702 0.3252 RANGAP1/TBC1D4/ABR/IQGAP1/NRP1/GNB5/CHN1/THY1/ARHGEF15/RASA1/RGS2/ARFGAP2/WNT11/PLCB1/HTR2B/RABGAP1L/SEC23B/AGFG1 18 MF GO:0008013 beta-catenin binding 7/816 82/17697 0.08378 0.3731 0.3277 TCF7L2/PIN1/CD2AP/PTPRK/KLF4/SLC9A3R2/FOXO3 7 MF GO:0003714 transcription corepressor activity 16/816 238/17697 0.08479 0.3731 0.3277 NACC2/SIAH2/KDM5B/DRAP1/YAF2/WWTR1/TDP2/KLF12/TLE4/TSG101/SAP18/PAWR/HSF4/RYBP/CRYM/CREBBP 16 MF GO:0016493 C-C chemokine receptor activity 3/816 23/17697 0.08723 0.3731 0.3277 CCRL2/CCR3/CCR1 3 MF GO:0017134 fibroblast growth factor binding 3/816 23/17697 0.08723 0.3731 0.3277 THBS1/S100A13/ITGB3 3 MF GO:0051371 muscle alpha-actinin binding 3/816 23/17697 0.08723 0.3731 0.3277 PDLIM1/PALLD/PDLIM7 3 MF GO:0001055 RNA polymerase II activity 2/816 11/17697 0.08864 0.3731 0.3277 POLR2L/POLR2E 2 MF GO:0005247 voltage-gated chloride channel activity 2/816 11/17697 0.08864 0.3731 0.3277 CLCN7/CLCN6 2 MF GO:0008429 phosphatidylethanolamine binding 2/816 11/17697 0.08864 0.3731 0.3277 ESYT1/PLTP 2 MF GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors 2/816 11/17697 0.08864 0.3731 0.3277 UQCRQ/UQCRC1 2 MF GO:0017166 vinculin binding 2/816 11/17697 0.08864 0.3731 0.3277 ACTN1/SORBS3 2 MF GO:0031386 protein tag 2/816 11/17697 0.08864 0.3731 0.3277 ISG15/NEDD8 2 MF GO:0035004 phosphatidylinositol 3-kinase activity 2/816 11/17697 0.08864 0.3731 0.3277 PIK3C3/PIK3CB 2 MF GO:0036122 BMP binding 2/816 11/17697 0.08864 0.3731 0.3277 GREM1/COMP 2 MF GO:0043422 protein kinase B binding 2/816 11/17697 0.08864 0.3731 0.3277 ARRB2/BAD 2 MF GO:0050786 RAGE receptor binding 2/816 11/17697 0.08864 0.3731 0.3277 FPR1/S100A13 2 MF GO:0051393 alpha-actinin binding 4/816 37/17697 0.08924 0.3738 0.3283 PDLIM1/PALLD/CACNA1C/PDLIM7 4 MF GO:0004601 peroxidase activity 5/816 52/17697 0.0905 0.3738 0.3283 CLIC2/PXDN/GPX4/GPX3/CAT 5 MF GO:0005070 SH3/SH2 adaptor activity 5/816 52/17697 0.0905 0.3738 0.3283 STAM/CHN1/GRB10/PTPN11/NCK1 5 MF GO:0008146 sulfotransferase activity 5/816 52/17697 0.0905 0.3738 0.3283 NDST1/CHST7/SULT1C2/CHST2/SULT2B1 5 MF GO:0043177 organic acid binding 14/816 205/17697 0.09263 0.3808 0.3345 VDR/CEMIP/HMGCL/DDAH2/FOLR3/FOLR2/NDUFAB1/P4HA1/HAPLN1/GLRB/GRIN2B/ACAN/VCAN/NCAN 14 MF GO:0016248 channel inhibitor activity 4/816 38/17697 0.09629 0.391 0.3434 CAV3/RASA1/BCL2/ENSA 4 MF GO:0001965 G-protein alpha-subunit binding 3/816 24/17697 0.09643 0.391 0.3434 RGS2/LPAR1/HTR2B 3 MF GO:0120013 intermembrane lipid transfer activity 3/816 24/17697 0.09643 0.391 0.3434 GRAMD1B/ABCG1/PLTP 3 MF GO:0016782 transferase activity, transferring sulfur-containing groups 6/816 69/17697 0.09803 0.3931 0.3453 NDST1/CHST7/OXCT1/SULT1C2/CHST2/SULT2B1 6 MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/816 119/17697 0.0988 0.3931 0.3453 IDH2/SORD/ADH1C/LDHA/HADH/ADH1A/ABCC4/ADH1B/MDH2 9 MF GO:0031072 heat shock protein binding 9/816 119/17697 0.0988 0.3931 0.3453 ARNTL/TOMM34/HSPA5/ITGB2/HSPA2/FKBP4/HIF1A/DNAJC2/ZFP36 9 MF GO:0030165 PDZ domain binding 7/816 86/17697 0.1016 0.3931 0.3453 FZD7/GJA1/FZD2/SNTA1/GNG12/LPAR1/FZD1 7 MF GO:0001054 RNA polymerase I activity 2/816 12/17697 0.1032 0.3931 0.3453 POLR2L/POLR2E 2 MF GO:0004000 adenosine deaminase activity 2/816 12/17697 0.1032 0.3931 0.3453 ADARB1/ADAR 2 MF GO:0004126 cytidine deaminase activity 2/816 12/17697 0.1032 0.3931 0.3453 APOBEC3B/APOBEC3C 2 MF GO:0005542 folic acid binding 2/816 12/17697 0.1032 0.3931 0.3453 FOLR3/FOLR2 2 MF GO:0008239 dipeptidyl-peptidase activity 2/816 12/17697 0.1032 0.3931 0.3453 PRCP/FAP 2 MF GO:0019992 diacylglycerol binding 2/816 12/17697 0.1032 0.3931 0.3453 PLTP/UNC13B 2 MF GO:0030898 actin-dependent ATPase activity 2/816 12/17697 0.1032 0.3931 0.3453 MYO10/MYH9 2 MF GO:0042301 phosphate ion binding 2/816 12/17697 0.1032 0.3931 0.3453 MTHFD2/GNG12 2 MF GO:0045295 gamma-catenin binding 2/816 12/17697 0.1032 0.3931 0.3453 TCF7L2/PTPRK 2 MF GO:0051011 microtubule minus-end binding 2/816 12/17697 0.1032 0.3931 0.3453 HAUS7/CAMSAP2 2 MF GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/816 39/17697 0.1036 0.3931 0.3453 PLEKHB2/HIP1R/MYO10/IQGAP1 4 MF GO:0008139 nuclear localization sequence binding 3/816 25/17697 0.106 0.4006 0.3518 NOLC1/NUP153/KPNA3 3 MF GO:0017022 myosin binding 6/816 71/17697 0.1087 0.409 0.3592 MYOC/TRAK2/RAB27B/MYRIP/GSN/RAB8A 6 MF GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/816 40/17697 0.1111 0.4164 0.3658 UBE2G1/UBE2J1/UBE2I/UBE2E1 4 MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/816 56/17697 0.115 0.4223 0.3709 CLIC2/PXDN/GPX4/GPX3/CAT 5 MF GO:0016836 hydro-lyase activity 5/816 56/17697 0.115 0.4223 0.3709 ECI1/ACO2/PCBD1/AUH/UROS 5 MF GO:0001637 G protein-coupled chemoattractant receptor activity 3/816 26/17697 0.1159 0.4223 0.3709 CCRL2/CCR3/CCR1 3 MF GO:0004435 phosphatidylinositol phospholipase C activity 3/816 26/17697 0.1159 0.4223 0.3709 CCR1/PLCB1/EDNRA 3 MF GO:0004950 chemokine receptor activity 3/816 26/17697 0.1159 0.4223 0.3709 CCRL2/CCR3/CCR1 3 MF GO:0030515 snoRNA binding 3/816 26/17697 0.1159 0.4223 0.3709 NOLC1/NHP2/BYSL 3 MF GO:0005253 anion channel activity 7/816 89/17697 0.1163 0.4223 0.3709 CLIC2/CLIC1/CLDN4/CLCN7/GLRB/CLCN6/CLIC5 7 MF GO:0005452 inorganic anion exchanger activity 2/816 13/17697 0.1184 0.4223 0.3709 SLC4A4/SLC4A3 2 MF GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/816 13/17697 0.1184 0.4223 0.3709 CYP3A4/RRM2 2 MF GO:0070679 inositol 1,4,5 trisphosphate binding 2/816 13/17697 0.1184 0.4223 0.3709 ITPR3/TRPC6 2 MF GO:0072542 protein phosphatase activator activity 2/816 13/17697 0.1184 0.4223 0.3709 PPP2R5D/PHACTR4 2 MF GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/816 13/17697 0.1184 0.4223 0.3709 SYNJ2/INPP5E 2 MF GO:0001618 virus receptor activity 6/816 74/17697 0.1257 0.4394 0.386 CD55/SLC1A5/TNFRSF14/ITGB3/ITGA2/ITGB1 6 MF GO:0104005 hijacked molecular function 6/816 74/17697 0.1257 0.4394 0.386 CD55/SLC1A5/TNFRSF14/ITGB3/ITGA2/ITGB1 6 MF GO:0031210 phosphatidylcholine binding 3/816 27/17697 0.1262 0.4394 0.386 ESYT1/PLTP/CHMP2A 3 MF GO:0032452 histone demethylase activity 3/816 27/17697 0.1262 0.4394 0.386 KDM5B/PHF2/KDM6A 3 MF GO:0050997 quaternary ammonium group binding 3/816 27/17697 0.1262 0.4394 0.386 ESYT1/PLTP/CHMP2A 3 MF GO:0099604 ligand-gated calcium channel activity 3/816 27/17697 0.1262 0.4394 0.386 ITPR3/GRIN2B/GRIN2A 3 MF GO:0005095 GTPase inhibitor activity 2/816 14/17697 0.1341 0.4555 0.4001 IQGAP1/ARL2 2 MF GO:0050998 nitric-oxide synthase binding 2/816 14/17697 0.1341 0.4555 0.4001 SNTA1/CAV3 2 MF GO:0070403 NAD+ binding 2/816 14/17697 0.1341 0.4555 0.4001 HADH/ALDH1A3 2 MF GO:0001221 transcription cofactor binding 4/816 43/17697 0.1352 0.4555 0.4001 FOXC1/KLF4/PER2/FOXO3 4 MF GO:0004712 protein serine/threonine/tyrosine kinase activity 4/816 43/17697 0.1352 0.4555 0.4001 MAPK3/MAPKAPK3/MAP2K4/DYRK1B 4 MF GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/816 43/17697 0.1352 0.4555 0.4001 OGDH/ALDH2/ALDH1A3/ALDH7A1 4 MF GO:0004629 phospholipase C activity 3/816 28/17697 0.1368 0.4555 0.4001 CCR1/PLCB1/EDNRA 3 MF GO:0017056 structural constituent of nuclear pore 3/816 28/17697 0.1368 0.4555 0.4001 NUP205/NUP93/NUP153 3 MF GO:0017091 AU-rich element binding 3/816 28/17697 0.1368 0.4555 0.4001 EXOSC7/HNRNPA0/ZFP36 3 MF GO:0030507 spectrin binding 3/816 28/17697 0.1368 0.4555 0.4001 MYO10/DYNC1I1/CAMSAP2 3 MF GO:0043425 bHLH transcription factor binding 3/816 28/17697 0.1368 0.4555 0.4001 ARNTL/LMO2/CREBBP 3 MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 9/816 128/17697 0.137 0.4555 0.4001 IDH2/SORD/ADH1C/LDHA/HADH/ADH1A/ABCC4/ADH1B/MDH2 9 MF GO:0015103 inorganic anion transmembrane transporter activity 10/816 146/17697 0.1375 0.4555 0.4001 CLIC2/SLC4A4/CLIC1/CLDN4/SLC4A3/MFSD5/CLCN7/GLRB/CLCN6/CLIC5 10 MF GO:0008081 phosphoric diester hydrolase activity 7/816 94/17697 0.143 0.4705 0.4133 ENPP1/TDP2/PDE4B/CCR1/PLCB1/EDNRA/ENPP2 7 MF GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/816 44/17697 0.1436 0.4705 0.4133 GCLM/GART/MTHFD1/CTPS1 4 MF GO:0019205 nucleobase-containing compound kinase activity 4/816 44/17697 0.1436 0.4705 0.4133 NME3/AK1/TK2/GUK1 4 MF GO:0071889 14-3-3 protein binding 3/816 29/17697 0.1476 0.4781 0.4199 ARRB2/ZFP36/BAD 3 MF GO:0005024 transforming growth factor beta-activated receptor activity 2/816 15/17697 0.1502 0.4781 0.4199 LTBP1/TGFBR1 2 MF GO:0005161 platelet-derived growth factor receptor binding 2/816 15/17697 0.1502 0.4781 0.4199 ITGB3/PDGFA 2 MF GO:0005243 gap junction channel activity 2/816 15/17697 0.1502 0.4781 0.4199 GJA1/GJC1 2 MF GO:0005523 tropomyosin binding 2/816 15/17697 0.1502 0.4781 0.4199 TMOD1/LMOD1 2 MF GO:0015037 peptide disulfide oxidoreductase activity 2/816 15/17697 0.1502 0.4781 0.4199 GSTO1/TXN 2 MF GO:0015269 calcium-activated potassium channel activity 2/816 15/17697 0.1502 0.4781 0.4199 KCNN4/KCNMB1 2 MF GO:0016594 glycine binding 2/816 15/17697 0.1502 0.4781 0.4199 GLRB/GRIN2B 2 MF GO:0003697 single-stranded DNA binding 8/816 113/17697 0.1508 0.4781 0.42 RAD23A/FUBP1/TDP2/RPA3/TERF2/PRIM1/XPC/PCBP3 8 MF GO:0004180 carboxypeptidase activity 4/816 45/17697 0.1522 0.4811 0.4226 PRCP/CPB1/CTSA/CPM 4 MF GO:0019208 phosphatase regulator activity 7/816 96/17697 0.1544 0.4862 0.4271 PPP1R7/ANKLE2/ANP32E/ENSA/PPP2R1A/PPP2R5D/PHACTR4 7 MF GO:0016829 lyase activity 12/816 187/17697 0.1558 0.489 0.4295 ECI1/ACO2/PCBD1/ADCY8/HMGCL/GGCT/ADCY7/AUH/XRCC6/UROS/BST1/TPI1 12 MF GO:0008201 heparin binding 11/816 169/17697 0.1581 0.4944 0.4342 THBS4/THBS1/COL11A1/POSTN/SOD3/COMP/BMP4/LTBP2/NRP1/ZNF146/NRP2 11 MF GO:0035091 phosphatidylinositol binding 15/816 245/17697 0.1618 0.5043 0.443 PLEKHB2/HIP1R/ESYT1/FZD7/GAP43/MCF2L/MYO10/IQGAP1/ITPR3/TWF2/SNX27/THY1/PLCB1/SH3YL1/SH3PXD2A 15 MF GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/816 16/17697 0.1667 0.5086 0.4468 LOX/LOXL2 2 MF GO:0019211 phosphatase activator activity 2/816 16/17697 0.1667 0.5086 0.4468 PPP2R5D/PHACTR4 2 MF GO:0032183 SUMO binding 2/816 16/17697 0.1667 0.5086 0.4468 HABP4/USPL1 2 MF GO:0035259 glucocorticoid receptor binding 2/816 16/17697 0.1667 0.5086 0.4468 FKBP4/STAT3 2 MF GO:0043395 heparan sulfate proteoglycan binding 2/816 16/17697 0.1667 0.5086 0.4468 COMP/ITGA2 2 MF GO:0070402 NADPH binding 2/816 16/17697 0.1667 0.5086 0.4468 LBR/QDPR 2 MF GO:0004879 nuclear receptor activity 4/816 47/17697 0.1701 0.512 0.4497 VDR/NR1H2/NR1H3/STAT3 4 MF GO:0008374 O-acyltransferase activity 4/816 47/17697 0.1701 0.512 0.4497 PLA2G15/LPGAT1/ABHD5/AGPAT1 4 MF GO:0016860 intramolecular oxidoreductase activity 4/816 47/17697 0.1701 0.512 0.4497 ECI1/ITGB3/GNPDA1/TPI1 4 MF GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding 4/816 47/17697 0.1701 0.512 0.4497 VDR/NR1H2/NR1H3/STAT3 4 MF GO:0019888 protein phosphatase regulator activity 6/816 82/17697 0.1769 0.5307 0.4662 PPP1R7/ANKLE2/ENSA/PPP2R1A/PPP2R5D/PHACTR4 6 MF GO:0015108 chloride transmembrane transporter activity 7/816 100/17697 0.1785 0.5323 0.4676 CLIC2/CLIC1/CLDN4/CLCN7/GLRB/CLCN6/CLIC5 7 MF GO:0003684 damaged DNA binding 5/816 65/17697 0.1799 0.5323 0.4676 RAD23A/XRCC6/RPA3/XPC/CREBBP 5 MF GO:0031624 ubiquitin conjugating enzyme binding 3/816 32/17697 0.1817 0.5323 0.4676 SIAH2/ZMYM2/RNF144A 3 MF GO:0004551 nucleotide diphosphatase activity 2/816 17/17697 0.1834 0.5323 0.4676 ENPP1/ENPP2 2 MF GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/816 17/17697 0.1834 0.5323 0.4676 LTBP1/TGFBR1 2 MF GO:0008308 voltage-gated anion channel activity 2/816 17/17697 0.1834 0.5323 0.4676 CLCN7/CLCN6 2 MF GO:0008484 sulfuric ester hydrolase activity 2/816 17/17697 0.1834 0.5323 0.4676 IDS/SULF1 2 MF GO:0031489 myosin V binding 2/816 17/17697 0.1834 0.5323 0.4676 RAB27B/RAB8A 2 MF GO:0046965 retinoid X receptor binding 2/816 17/17697 0.1834 0.5323 0.4676 VDR/HMGA1 2 MF GO:0048038 quinone binding 2/816 17/17697 0.1834 0.5323 0.4676 NDUFS7/SDHB 2 MF GO:0000287 magnesium ion binding 13/816 213/17697 0.1858 0.5375 0.4721 PI4K2A/IDH2/ATP8A1/MTHFD2/HMGCL/STK38L/PRPSAP2/ATP11B/MAST4/TDP2/MAP3K5/MAST2/PGM1 13 MF GO:0030246 carbohydrate binding 16/816 271/17697 0.1872 0.5386 0.4731 PRG4/ENPP1/SORD/NPTX2/P4HA1/FBP1/MRC2/LOXL2/ACAN/CHI3L1/PTX3/ENPP2/VCAN/LMAN1/NCAN/LGALS2 16 MF GO:0002039 p53 binding 5/816 66/17697 0.1878 0.5386 0.4731 HIF1A/PTTG1IP/USP10/RCHY1/CREBBP 5 MF GO:0015485 cholesterol binding 4/816 49/17697 0.1886 0.5386 0.4731 GRAMD1B/ABCG1/NR1H3/SULT2B1 4 MF GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/816 49/17697 0.1886 0.5386 0.4731 KAT2B/CCND2/HEXIM1/CDKN2A 4 MF GO:0042562 hormone binding 7/816 102/17697 0.1911 0.5438 0.4776 VDR/RAMP2/PIK3R1/GHR/SULT2B1/ALDH1A3/CRYM 7 MF GO:0005154 epidermal growth factor receptor binding 3/816 33/17697 0.1935 0.549 0.4823 ARF4/EFEMP1/SOCS5 3 MF GO:0004222 metalloendopeptidase activity 7/816 103/17697 0.1975 0.5545 0.487 BMP1/ADAM12/ADAM15/FAP/ADAM19/MMP17/ADAMDEC1 7 MF GO:0043178 alcohol binding 6/816 85/17697 0.198 0.5545 0.487 GRAMD1B/ABCG1/NR1H3/ITPR3/SULT2B1/TRPC6 6 MF GO:0070888 E-box binding 4/816 50/17697 0.1981 0.5545 0.487 ARNTL/LMO2/SNAI2/HIF1A 4 MF GO:0098632 cell-cell adhesion mediator activity 4/816 50/17697 0.1981 0.5545 0.487 PDLIM1/PALLD/CDC42EP1/KRT18 4 MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/816 159/17697 0.1994 0.5545 0.487 MICAL2/CYP1B1/PCBD1/FMO1/P4HA1/FMO3/CYP3A4/CYP27A1/TYR/FMO2 10 MF GO:0017127 cholesterol transporter activity 2/816 18/17697 0.2004 0.5545 0.487 GRAMD1B/ABCG1 2 MF GO:0070064 proline-rich region binding 2/816 18/17697 0.2004 0.5545 0.487 GHR/WBP4 2 MF GO:0120020 intermembrane cholesterol transfer activity 2/816 18/17697 0.2004 0.5545 0.487 GRAMD1B/ABCG1 2