ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04510	Focal adhesion	36/488	201/8135	2.188e-09	3.864e-07	2.42e-07	MAPK3/ACTN1/COL1A2/THBS4/THBS1/PRKCA/COL1A1/ITGA1/COMP/LAMB1/PIK3R1/VEGFC/CCND2/MYLK/COL6A3/DIAPH1/MET/ITGB3/ITGA3/PDGFA/PIK3R2/FLNB/PIK3CB/COL4A1/RAPGEF1/CAV3/LAMA1/ITGA6/PRKCB/BAD/BCL2/TNC/ITGA2/PIP5K1A/COL4A2/ITGB1	36
KEGG	hsa05165	Human papillomavirus infection	49/488	331/8135	2.408e-09	3.864e-07	2.42e-07	MAPK3/ATP6V0E2/COL1A2/THBS4/THBS1/CREB3L2/TCF7L2/ATP6V0A1/FZD7/COL1A1/ITGA1/ISG15/COMP/ATP6V0D1/MAML1/LAMB1/ATP6V1E1/PIK3R1/FZD2/CCND2/ATP6V0C/ATP6V1H/COL6A3/ITGB3/ITGA3/FZD6/PIK3R2/PIK3CB/COL4A1/NOTCH3/LAMA1/OASL/ITGA6/WNT11/MTOR/BAD/RPS6KB2/TNC/TCIRG1/PPP2R1A/ITGA2/PPP2R5D/FZD1/ATP6V1D/COL4A2/MX1/MX2/CREBBP/ITGB1	49
KEGG	hsa04512	ECM-receptor interaction	20/488	88/8135	1.665e-07	1.781e-05	1.116e-05	COL1A2/THBS4/THBS1/COL1A1/ITGA1/COMP/LAMB1/SV2A/HSPG2/COL6A3/ITGB3/ITGA3/COL4A1/LAMA1/ITGA6/TNC/ITGA2/COL4A2/SDC4/ITGB1	20
KEGG	hsa04151	PI3K-Akt signaling pathway	46/488	354/8135	4.238e-07	3.401e-05	2.13e-05	MAPK3/COL1A2/THBS4/THBS1/CREB3L2/PRKCA/COL1A1/ITGA1/COMP/ANGPT1/LAMB1/NTRK2/PIK3R1/VEGFC/BCL2L1/CCND2/GHR/COL6A3/GNB5/MET/OSMR/ITGB3/ITGA3/PDGFA/PIK3R2/GNG12/PIK3CB/COL4A1/LAMA1/JAK2/ITGA6/IL4R/LPAR1/MTOR/BAD/RPS6KB2/BCL2/TNC/PPP2R1A/ITGA2/PPP2R5D/COL4A2/CASP9/FOXO3/PKN1/ITGB1	46
KEGG	hsa05205	Proteoglycans in cancer	31/488	205/8135	1.479e-06	9.496e-05	5.948e-05	MAPK3/COL1A2/THBS1/PRKCA/FZD7/COL1A1/PIK3R1/HSPG2/FZD2/IQGAP1/HIF1A/MET/ITPR3/ITGB3/FZD6/PIK3R2/FLNB/PIK3CB/CAV3/STAT3/TGFB2/PRKCB/WNT11/MTOR/RPS6KB2/ITGA2/FZD1/PTPN11/SDC4/EZR/ITGB1	31
KEGG	hsa04974	Protein digestion and absorption	20/488	103/8135	2.401e-06	0.0001202	7.526e-05	COL8A1/COL5A2/COL3A1/COL16A1/SLC7A8/PRCP/COL1A2/CPB1/COL11A1/COL1A1/ELN/COL14A1/SLC1A5/COL6A3/KCNN4/COL7A1/COL15A1/COL4A1/ATP1B1/COL4A2	20
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/488	79/8135	3.172e-06	0.0001202	7.526e-05	MAPK3/PRKCA/PIK3R1/BCL2L1/MET/PDGFA/PIK3R2/PIK3CB/STAT3/JAK2/GAS6/PRKCB/MTOR/BAD/RPS6KB2/BCL2/FOXO3	17
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	54/488	476/8135	3.183e-06	0.0001202	7.526e-05	MAPK3/NDUFB8/PSMD8/PSMB7/PRKCA/ATP2A2/FZD7/SDHA/ATG2A/PSMD1/HSPA5/BCL2L1/NDUFAB1/FZD2/UBE2G1/NDUFS6/PIK3C3/MAP3K5/NDUFA7/ITPR3/PSMB6/FZD6/SPG11/NDUFS3/TRAP1/NDUFS7/FIG4/UBE2J1/COX5B/UQCRQ/SDHB/GPX3/GRIN2B/PRKCB/WNT11/RAB8A/UQCRC1/MTOR/SIGMAR1/COX7A2/BAD/BCL2/PLCB1/CACNA1C/NDUFA1/FZD1/CAT/NDUFB7/MAP1LC3B/PSMD3/CASP9/PSMD2/UBA1/GRIN2A	54
KEGG	hsa04145	Phagosome	25/488	152/8135	3.369e-06	0.0001202	7.526e-05	ATP6V0E2/THBS4/THBS1/ATP6V0A1/COMP/ATP6V0D1/ATP6V1E1/ITGB2/ATP6V0C/PIK3C3/ATP6V1H/ITGB3/DYNC1I1/MRC2/HLA-DRB4/C1R/HLA-DQB1/TCIRG1/ITGA2/ATP6V1D/TAP1/PIKFYVE/VAMP3/ITGB1/HLA-DPB1	25
KEGG	hsa05014	Amyotrophic lateral sclerosis	44/488	364/8135	5.447e-06	0.0001748	0.0001095	NDUFB8/PSMD8/PSMB7/SDHA/ATG2A/PSMD1/HSPA5/BCL2L1/NDUFAB1/NDUFS6/PIK3C3/MAP3K5/NDUFA7/ITPR3/PSMB6/SPG11/NUP205/NDUFS3/NUP93/NUP153/NDUFS7/FIG4/COX5B/UQCRQ/SDHB/GPX3/GRIN2B/SEC13/RAB8A/UQCRC1/MTOR/SIGMAR1/COX7A2/BAD/BCL2/NDUFA1/CAT/NDUFB7/MAP1LC3B/PSMD3/SRSF7/CASP9/PSMD2/GRIN2A	44
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/488	100/8135	5.998e-06	0.000175	0.0001096	MAPK3/COL3A1/COL1A2/PRKCA/COL1A1/TGFBR1/PIK3R1/VEGFC/DIAPH1/PIK3R2/PIK3CB/COL4A1/STAT3/TGFB2/JAK2/PRKCB/BCL2/PLCB1/COL4A2	19
KEGG	hsa05415	Diabetic cardiomyopathy	29/488	203/8135	1.018e-05	0.0002724	0.0001706	COL3A1/COL1A2/NDUFB8/PRKCA/ATP2A2/COL1A1/SDHA/TBC1D4/TGFBR1/PIK3R1/NDUFAB1/NDUFS6/NDUFA7/NDUFS3/NDUFS7/PIK3R2/PIK3CB/COX5B/UQCRQ/TGFB2/SDHB/PRKCB/UQCRC1/MTOR/COX7A2/PLCB1/NDUFA1/NDUFB7/PDK2	29
KEGG	hsa00190	Oxidative phosphorylation	22/488	134/8135	1.344e-05	0.0003318	0.0002078	ATP6V0E2/NDUFB8/ATP6V0A1/SDHA/ATP6V0D1/ATP6V1E1/NDUFAB1/NDUFS6/ATP6V0C/ATP6V1H/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/SDHB/UQCRC1/COX7A2/TCIRG1/NDUFA1/ATP6V1D/NDUFB7	22
KEGG	hsa04926	Relaxin signaling pathway	21/488	129/8135	2.405e-05	0.0005515	0.0003454	MAPK3/COL3A1/COL1A2/CREB3L2/PRKCA/ADCY8/COL1A1/TGFBR1/PIK3R1/VEGFC/ADCY7/GNB5/PIK3R2/GNG12/PIK3CB/COL4A1/ARRB2/MAP2K4/PLCB1/COL4A2/ACTA2	21
KEGG	hsa05146	Amoebiasis	18/488	102/8135	3.02e-05	0.0006463	0.0004048	COL3A1/ACTN1/COL1A2/PRKCA/COL1A1/LAMB1/PIK3R1/IL12A/ITGB2/PIK3R2/PIK3CB/COL4A1/SERPINB6/TGFB2/LAMA1/PRKCB/PLCB1/COL4A2	18
KEGG	hsa05020	Prion disease	34/488	273/8135	3.555e-05	0.0007132	0.0004467	MAPK3/NDUFB8/CREB3L2/PSMD8/PSMB7/SDHA/PIK3R1/PSMD1/HSPA5/NDUFAB1/HSPA2/NDUFS6/NDUFA7/ITPR3/PSMB6/NDUFS3/NDUFS7/PIK3R2/PIK3CB/CAV3/COX5B/UQCRQ/SDHB/GRIN2B/UQCRC1/COX7A2/BAD/CACNA1C/NDUFA1/NDUFB7/PSMD3/CASP9/PSMD2/GRIN2A	34
KEGG	hsa05017	Spinocerebellar ataxia	22/488	143/8135	3.82e-05	0.0007212	0.0004517	PSMD8/PSMB7/PRKCA/ATP2A2/PIK3R1/ATG2A/PSMD1/KCND3/PIK3C3/MAP3K5/ITPR3/PSMB6/PIK3R2/PIK3CB/GRIN2B/PRKCB/MTOR/PLCB1/PSMD3/PSMD2/GRIN2A/VLDLR	22
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	29/488	223/8135	6.109e-05	0.001089	0.0006824	MAPK3/GSTO1/NDUFB8/CYP1B1/SDHA/PIK3R1/PRKD1/NDUFAB1/NDUFS6/MAP3K5/NDUFA7/HIF1A/MET/NDUFS3/NDUFS7/PIK3R2/PIK3CB/COX5B/UQCRQ/SDHB/UQCRC1/COX7A2/BAD/MAP2K4/NDUFA1/CAT/NDUFB7/PTPN11/FOXO3	29
KEGG	hsa03250	Viral life cycle - HIV-1	13/488	63/8135	7.295e-05	0.001231	0.0007709	PIN1/APOBEC3B/KAT2B/SERINC5/NUP153/ELL2/SUPT4H1/APOBEC3C/TSG101/MAP1A/MX1/MX2/CREBBP	13
KEGG	hsa04935	Growth hormone synthesis, secretion and action	19/488	119/8135	7.668e-05	0.001231	0.0007709	MAPK3/CREB3L2/PRKCA/ADCY8/PIK3R1/ADCY7/GHR/ITPR3/PIK3R2/PIK3CB/STAT3/JAK2/PRKCB/SOCS3/MTOR/MAP2K4/PLCB1/CACNA1C/CREBBP	19
KEGG	hsa04919	Thyroid hormone signaling pathway	19/488	121/8135	9.663e-05	0.001477	0.0009251	MAPK3/PRKCA/ATP2A2/BMP4/TBC1D4/PIK3R1/KAT2B/HIF1A/ITGB3/PIK3R2/PIK3CB/ATP1B1/NOTCH3/PRKCB/MTOR/BAD/PLCB1/CASP9/CREBBP	19
KEGG	hsa05016	Huntington disease	35/488	306/8135	0.0001575	0.002298	0.00144	POLR2L/NDUFB8/CREB3L2/PSMD8/POLR2E/PSMB7/CLTB/SDHA/ATG2A/PSMD1/TGM2/NDUFAB1/NDUFS6/PIK3C3/MAP3K5/NDUFA7/PSMB6/NDUFS3/NDUFS7/COX5B/UQCRQ/SDHB/GPX3/GRIN2B/UQCRC1/MTOR/COX7A2/PLCB1/AP2B1/NDUFA1/NDUFB7/PSMD3/CASP9/PSMD2/CREBBP	35
KEGG	hsa05010	Alzheimer disease	41/488	384/8135	0.0002009	0.002804	0.001756	MAPK3/NDUFB8/PSMD8/PSMB7/ATP2A2/FZD7/SDHA/PIK3R1/ATG2A/PSMD1/NDUFAB1/FZD2/NDUFS6/PIK3C3/MAP3K5/NDUFA7/ITPR3/PSMB6/FZD6/NDUFS3/NDUFS7/PIK3R2/PIK3CB/COX5B/UQCRQ/SDHB/GRIN2B/WNT11/UQCRC1/MTOR/COX7A2/BAD/PLCB1/CACNA1C/NDUFA1/FZD1/NDUFB7/PSMD3/CASP9/PSMD2/GRIN2A	41
KEGG	hsa05145	Toxoplasmosis	17/488	112/8135	0.0003379	0.004519	0.00283	MAPK3/LAMB1/IL12A/BCL2L1/HSPA2/HLA-DRB4/STAT3/TGFB2/LAMA1/JAK2/ITGA6/HLA-DQB1/BAD/BCL2/CASP9/ITGB1/HLA-DPB1	17
KEGG	hsa04929	GnRH secretion	12/488	64/8135	0.0003554	0.004563	0.002858	MAPK3/PRKCA/PIK3R1/ITPR3/KCNN4/PIK3R2/PIK3CB/ARRB2/GABBR1/PRKCB/PLCB1/CACNA1C	12
KEGG	hsa05323	Rheumatoid arthritis	15/488	93/8135	0.0003839	0.004645	0.002909	ATP6V0E2/ATP6V0A1/CXCL12/ATP6V0D1/ANGPT1/ATP6V1E1/ITGB2/ATP6V0C/ATP6V1H/HLA-DRB4/TGFB2/HLA-DQB1/TCIRG1/ATP6V1D/HLA-DPB1	15
KEGG	hsa04150	mTOR signaling pathway	21/488	156/8135	0.0003907	0.004645	0.002909	MAPK3/PRKCA/FZD7/ATP6V1E1/RRAGD/PIK3R1/FZD2/LAMTOR5/ATP6V1H/FZD6/PIK3R2/PIK3CB/GRB10/SEC13/PRKCB/WNT11/CLIP1/MTOR/RPS6KB2/FZD1/ATP6V1D	21
KEGG	hsa05225	Hepatocellular carcinoma	22/488	168/8135	0.0004233	0.004853	0.003039	MAPK3/GSTO1/TCF7L2/PRKCA/FZD7/TGFBR1/PIK3R1/BCL2L1/FZD2/MET/FZD6/PIK3R2/PIK3CB/TGFB2/PRKCB/WNT11/MTOR/BAD/RPS6KB2/FZD1/SMARCE1/CDKN2A	22
KEGG	hsa05212	Pancreatic cancer	13/488	76/8135	0.0005204	0.005639	0.003532	MAPK3/TGFBR1/PIK3R1/BCL2L1/PIK3R2/PIK3CB/STAT3/TGFB2/MTOR/BAD/RPS6KB2/CASP9/CDKN2A	13
KEGG	hsa05164	Influenza A	22/488	171/8135	0.0005421	0.005639	0.003532	MAPK3/PRKCA/OAS1/OAS2/PIK3R1/ADAR/IL12A/TRIM25/PIK3R2/HLA-DRB4/PIK3CB/JAK2/RSAD2/PRKCB/SOCS3/HLA-DQB1/IRF7/CASP9/MX1/MX2/CREBBP/HLA-DPB1	22
KEGG	hsa05414	Dilated cardiomyopathy	15/488	96/8135	0.0005446	0.005639	0.003532	TPM2/ADCY8/ATP2A2/ITGA1/ADCY7/TPM1/ITGB3/ITGA3/TGFB2/LAMA1/ITGA6/SGCA/CACNA1C/ITGA2/ITGB1	15
KEGG	hsa05012	Parkinson disease	30/488	266/8135	0.000585	0.005868	0.003675	NDUFB8/PSMD8/PSMB7/TXN/SDHA/PSMD1/HSPA5/BCL2L1/NDUFAB1/UBE2G1/NDUFS6/MAP3K5/NDUFA7/ITPR3/PSMB6/NDUFS3/TRAP1/NDUFS7/UBE2J1/COX5B/UQCRQ/SDHB/UQCRC1/COX7A2/NDUFA1/NDUFB7/PSMD3/CASP9/PSMD2/UBA1	30
KEGG	hsa04070	Phosphatidylinositol signaling system	15/488	97/8135	0.0006096	0.005929	0.003714	PI4K2A/SYNJ2/PRKCA/PIK3R1/PIK3C3/ITPR3/CDS1/CDS2/PIK3R2/PIK3CB/PRKCB/INPP5E/PLCB1/PIP5K1A/PIKFYVE	15
KEGG	hsa05110	Vibrio cholerae infection	10/488	50/8135	0.0006419	0.005974	0.003742	ATP6V0E2/ATP6V0A1/KDELR3/PRKCA/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/TCIRG1/ATP6V1D	10
KEGG	hsa04630	JAK-STAT signaling pathway	21/488	162/8135	0.0006514	0.005974	0.003742	STAM/PIK3R1/IL12A/BCL2L1/CCND2/GHR/OSMR/IL13RA2/PDGFA/PIK3R2/PIK3CB/STAT3/JAK2/SOCS5/IL6ST/SOCS3/IL4R/MTOR/BCL2/PTPN11/CREBBP	21
KEGG	hsa05211	Renal cell carcinoma	12/488	69/8135	0.0007258	0.006471	0.004053	MAPK3/PIK3R1/HIF1A/MET/EPAS1/PIK3R2/PIK3CB/RAPGEF1/TGFB2/BAD/PTPN11/CREBBP	12
KEGG	hsa04966	Collecting duct acid secretion	7/488	27/8135	0.0008299	0.0072	0.00451	ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/TCIRG1/ATP6V1D	7
KEGG	hsa04932	Non-alcoholic fatty liver disease	20/488	155/8135	0.0009222	0.007734	0.004844	NDUFB8/SDHA/PIK3R1/NDUFAB1/NR1H3/NDUFS6/MAP3K5/NDUFA7/NDUFS3/NDUFS7/PIK3R2/PIK3CB/COX5B/UQCRQ/SDHB/SOCS3/UQCRC1/COX7A2/NDUFA1/NDUFB7	20
KEGG	hsa04916	Melanogenesis	15/488	101/8135	0.0009396	0.007734	0.004844	MAPK3/CREB3L2/TCF7L2/PRKCA/ADCY8/FZD7/ADCY7/FZD2/TYR/FZD6/PRKCB/WNT11/PLCB1/FZD1/CREBBP	15
KEGG	hsa04213	Longevity regulating pathway - multiple species	11/488	62/8135	0.001009	0.007953	0.004981	CRYAB/ADCY8/PIK3R1/ADCY7/HSPA2/PIK3R2/PIK3CB/MTOR/RPS6KB2/CAT/FOXO3	11
KEGG	hsa05223	Non-small cell lung cancer	12/488	72/8135	0.001074	0.007953	0.004981	MAPK3/PRKCA/PIK3R1/MET/PIK3R2/PIK3CB/STAT3/PRKCB/BAD/CASP9/FOXO3/CDKN2A	12
KEGG	hsa05222	Small cell lung cancer	14/488	92/8135	0.00108	0.007953	0.004981	LAMB1/PIK3R1/BCL2L1/ITGA3/PIK3R2/PIK3CB/COL4A1/LAMA1/ITGA6/BCL2/ITGA2/COL4A2/CASP9/ITGB1	14
KEGG	hsa05152	Tuberculosis	22/488	180/8135	0.001089	0.007953	0.004981	MAPK3/VDR/ATP6V0A1/ATP6V0D1/IL12A/ITGB2/ATP6V0C/PIK3C3/ATP6V1H/MRC2/HLA-DRB4/TGFB2/RFX5/JAK2/HLA-DQB1/BAD/BCL2/TCIRG1/CASP9/CREBBP/NFYB/HLA-DPB1	22
KEGG	hsa04725	Cholinergic synapse	16/488	113/8135	0.00109	0.007953	0.004981	MAPK3/CREB3L2/PRKCA/ADCY8/PIK3R1/ADCY7/GNB5/ITPR3/PIK3R2/GNG12/PIK3CB/JAK2/PRKCB/BCL2/PLCB1/CACNA1C	16
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/488	194/8135	0.001285	0.008895	0.005571	MAPK3/TCF7L2/MICB/PIK3R1/PIK3C3/CCR3/GNB5/HIF1A/ITPR3/CCR1/PIK3R2/GNG12/PIK3CB/STAT3/JAK2/ZFP36/IL6ST/MTOR/IRF7/MAP2K4/MAP1LC3B/CASP9/CREBBP	23
KEGG	hsa04810	Regulation of actin cytoskeleton	25/488	218/8135	0.001299	0.008895	0.005571	MAPK3/ACTN1/CXCL12/ITGA1/PIK3R1/ITGB2/MYH9/IQGAP1/MYLK/DIAPH1/ITGB3/ITGA3/ARPC1B/GSN/PDGFA/PIK3R2/GNG12/PIK3CB/ITGA6/LPAR1/ITGA2/PIP5K1A/EZR/PIKFYVE/ITGB1	25
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	8/488	37/8135	0.001302	0.008895	0.005571	MAPK3/PRKCA/PIK3R1/PIK3R2/PIK3CB/ATP1B1/PRKCB/SLC9A3R2	8
KEGG	hsa05162	Measles	18/488	139/8135	0.00157	0.0105	0.006576	OAS1/OAS2/PIK3R1/ADAR/IL12A/BCL2L1/HSPA2/CCND2/PIK3R2/PIK3CB/STAT3/IRF7/BAD/BCL2/CASP9/MX1/RCHY1/MX2	18
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	14/488	97/8135	0.001821	0.01193	0.007473	MAPK3/PRKCA/MARCKSL1/PLA2G4C/PIK3R1/MYO10/ARPC1B/GSN/PIK3R2/PIK3CB/PRKCB/RPS6KB2/BIN1/PIP5K1A	14
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/488	77/8135	0.001956	0.01256	0.007866	TCF7L2/ATP2A2/ITGA1/GJA1/ITGB3/ITGA3/LAMA1/ITGA6/SGCA/CACNA1C/ITGA2/ITGB1	12
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	14/488	98/8135	0.002011	0.01266	0.007929	PRKCA/ADCY8/IL1RAP/PLA2G4C/PIK3R1/ADCY7/ITPR3/PIK3R2/PIK3CB/PRKCB/P2RY2/PLCB1/HTR2B/ASIC1	14
KEGG	hsa04066	HIF-1 signaling pathway	15/488	109/8135	0.002063	0.01273	0.007976	MAPK3/PRKCA/ANGPT1/PIK3R1/LDHA/HIF1A/PIK3R2/PIK3CB/STAT3/PDK1/PRKCB/MTOR/RPS6KB2/BCL2/CREBBP	15
KEGG	hsa04721	Synaptic vesicle cycle	12/488	78/8135	0.00219	0.01323	0.008288	ATP6V0E2/ATP6V0A1/CLTB/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/NAPA/UNC13B/TCIRG1/AP2B1/ATP6V1D	12
KEGG	hsa04142	Lysosome	17/488	132/8135	0.002226	0.01323	0.008288	PLA2G15/CTNS/CTSC/CTSA/CLN3/ATP6V0A1/CLTB/NAGLU/ATP6V0D1/GM2A/ATP6V0C/ATP6V1H/IDS/LIPA/WDR7/ASAH1/TCIRG1	17
KEGG	hsa04370	VEGF signaling pathway	10/488	59/8135	0.002418	0.01411	0.00884	MAPK3/MAPKAPK3/PRKCA/PLA2G4C/PIK3R1/PIK3R2/PIK3CB/PRKCB/BAD/CASP9	10
KEGG	hsa05410	Hypertrophic cardiomyopathy	13/488	90/8135	0.002601	0.01491	0.00934	TPM2/ATP2A2/ITGA1/TPM1/ITGB3/ITGA3/TGFB2/LAMA1/ITGA6/SGCA/CACNA1C/ITGA2/ITGB1	13
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/488	70/8135	0.002785	0.01542	0.009655	ATP6V0E2/ATP6V0A1/ATP6V0D1/ATP6V1E1/ATP6V0C/ATP6V1H/MET/MAP2K4/TCIRG1/ATP6V1D/PTPN11	11
KEGG	hsa05230	Central carbon metabolism in cancer	11/488	70/8135	0.002785	0.01542	0.009655	MAPK3/IDH2/PIK3R1/SLC1A5/LDHA/HIF1A/MET/PIK3R2/PIK3CB/PDK1/MTOR	11
KEGG	hsa04611	Platelet activation	16/488	124/8135	0.002909	0.01583	0.009914	MAPK3/COL3A1/COL1A2/ADCY8/COL1A1/PLA2G4C/PIK3R1/ADCY7/MYLK/ITPR3/ITGB3/PIK3R2/PIK3CB/PLCB1/ITGA2/ITGB1	16
KEGG	hsa04723	Retrograde endocannabinoid signaling	18/488	148/8135	0.00317	0.01696	0.01062	MAPK3/NDUFB8/PRKCA/ADCY8/ADCY7/NDUFAB1/NDUFS6/GNB5/NDUFA7/ITPR3/NDUFS3/NDUFS7/GNG12/PRKCB/PLCB1/CACNA1C/NDUFA1/NDUFB7	18
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	24/488	222/8135	0.003534	0.0186	0.01165	MAPK3/ESPL1/CREB3L2/ADCY8/TGFBR1/PIK3R1/ADCY7/KAT2B/ITGB2/BCL2L1/CCND2/NRP1/PIK3R2/HLA-DRB4/PIK3CB/TGFB2/ZFP36/HLA-DQB1/MAP2K4/ANAPC15/CDKN2A/CREBBP/NFYB/HLA-DPB1	24
KEGG	hsa04015	Rap1 signaling pathway	23/488	210/8135	0.003614	0.01871	0.01172	MAPK3/FPR1/THBS1/PRKCA/ADCY8/ANGPT1/PIK3R1/VEGFC/ADCY7/PRKD1/ITGB2/MET/ITGB3/PDGFA/PIK3R2/PIK3CB/RAPGEF1/GRIN2B/PRKCB/LPAR1/PLCB1/GRIN2A/ITGB1	23
KEGG	hsa04350	TGF-beta signaling pathway	13/488	94/8135	0.003833	0.01953	0.01223	MAPK3/GREM1/THBS1/LTBP1/BMP4/FMOD/TGIF2/TGFBR1/INHBB/TGFB2/RPS6KB2/PPP2R1A/CREBBP	13
KEGG	hsa01524	Platinum drug resistance	11/488	73/8135	0.003896	0.01954	0.01224	MAPK3/GSTO1/PIK3R1/BCL2L1/MAP3K5/PIK3R2/PIK3CB/BAD/BCL2/CASP9/CDKN2A	11
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	23/488	212/8135	0.004068	0.02009	0.01258	MAPK3/VDR/GSTO1/CREB3L2/CYP1B1/PRKCA/ADCY8/PIK3R1/ADCY7/CYP3A4/PIK3R2/PIK3CB/STAT3/ARRB2/KLF4/JAK2/PRKCB/MTOR/BAD/RPS6KB2/BCL2/CACNA1C/KPNA3	23
KEGG	hsa05210	Colorectal cancer	12/488	86/8135	0.004994	0.02413	0.01512	MAPK3/TCF7L2/TGFBR1/PIK3R1/PIK3R2/PIK3CB/TGFB2/MTOR/BAD/RPS6KB2/BCL2/CASP9	12
KEGG	hsa04713	Circadian entrainment	13/488	97/8135	0.005038	0.02413	0.01512	MAPK3/PRKCA/ADCY8/ADCY7/GNB5/ITPR3/GNG12/GRIN2B/PRKCB/PLCB1/CACNA1C/PER2/GRIN2A	13
KEGG	hsa05140	Leishmaniasis	11/488	77/8135	0.005897	0.02765	0.01732	MAPK3/MARCKSL1/IL12A/ITGB2/HLA-DRB4/TGFB2/JAK2/PRKCB/HLA-DQB1/ITGB1/HLA-DPB1	11
KEGG	hsa05160	Hepatitis C	18/488	157/8135	0.005943	0.02765	0.01732	MAPK3/OAS1/OAS2/CLDN4/PIK3R1/NR1H3/IFIT1/PIK3R2/PIK3CB/STAT3/RSAD2/SOCS3/IRF7/BAD/PPP2R1A/CASP9/MX1/MX2	18
KEGG	hsa04720	Long-term potentiation	10/488	67/8135	0.00622	0.02794	0.0175	MAPK3/PRKCA/ADCY8/ITPR3/GRIN2B/PRKCB/PLCB1/CACNA1C/GRIN2A/CREBBP	10
KEGG	hsa05221	Acute myeloid leukemia	10/488	67/8135	0.00622	0.02794	0.0175	MAPK3/TCF7L2/PIK3R1/PIK3R2/PIK3CB/STAT3/MTOR/BAD/RPS6KB2/PER2	10
KEGG	hsa00620	Pyruvate metabolism	8/488	47/8135	0.006267	0.02794	0.0175	HAGH/ADH1C/LDHA/ADH1A/ADH1B/ALDH2/ALDH7A1/MDH2	8
KEGG	hsa00280	Valine, leucine and isoleucine degradation	8/488	48/8135	0.007136	0.03138	0.01965	OXCT1/PCCB/HMGCL/AUH/HADH/ALDH2/ALDH7A1/BCAT2	8
KEGG	hsa04972	Pancreatic secretion	13/488	102/8135	0.007702	0.03341	0.02093	SLC4A4/CPB1/PRKCA/ADCY8/ATP2A2/ADCY7/RAB27B/ITPR3/BST1/ATP1B1/PRKCB/RAB8A/PLCB1	13
KEGG	hsa00020	Citrate cycle (TCA cycle)	6/488	30/8135	0.007812	0.03344	0.02094	IDH2/ACO2/SDHA/OGDH/SDHB/MDH2	6
KEGG	hsa05161	Hepatitis B	18/488	162/8135	0.008188	0.03458	0.02166	MAPK3/CREB3L2/PRKCA/TGFBR1/PIK3R1/HSPG2/PIK3R2/PIK3CB/STAT3/TGFB2/JAK2/PRKCB/IRF7/BAD/BCL2/MAP2K4/CASP9/CREBBP	18
KEGG	hsa05163	Human cytomegalovirus infection	23/488	225/8135	0.008334	0.03474	0.02176	MAPK3/CREB3L2/PRKCA/ADCY8/CXCL12/PIK3R1/ADCY7/CCR3/GNB5/ITPR3/ITGB3/CCR1/PIK3R2/GNG12/PIK3CB/STAT3/PRKCB/MTOR/RPS6KB2/PLCB1/CASP9/TAP1/CDKN2A	23
KEGG	hsa04917	Prolactin signaling pathway	10/488	70/8135	0.008478	0.03489	0.02185	MAPK3/PIK3R1/CCND2/PIK3R2/PIK3CB/STAT3/JAK2/SOCS5/SOCS3/FOXO3	10
KEGG	hsa04912	GnRH signaling pathway	12/488	93/8135	0.009318	0.03786	0.02371	MAPK3/MAP3K4/PRKCA/ADCY8/PLA2G4C/ADCY7/ITPR3/PRKCB/MAP2K4/PLCB1/CACNA1C/GNRHR	12
KEGG	hsa04140	Autophagy - animal	16/488	141/8135	0.01012	0.04063	0.02545	MAPK3/RRAGD/PIK3R1/ATG2A/BCL2L1/PIK3C3/HIF1A/PIK3R2/PIK3CB/RAB8A/MTOR/BAD/RPS6KB2/BCL2/ATG4A/MAP1LC3B	16
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	13/488	106/8135	0.01055	0.0418	0.02618	MAPK3/VDR/CREB3L2/PRKCA/ADCY8/ADCY7/PDE4B/ITPR3/ARRB2/PRKCB/MMP17/BCL2/PLCB1	13
KEGG	hsa00562	Inositol phosphate metabolism	10/488	73/8135	0.01132	0.04431	0.02775	PI4K2A/SYNJ2/PIK3C3/FIG4/PIK3CB/INPP5E/PLCB1/PIP5K1A/TPI1/PIKFYVE	10
KEGG	hsa04714	Thermogenesis	23/488	232/8135	0.01184	0.04578	0.02867	NDUFB8/CREB3L2/ADCY8/SDHA/NDUFAF3/ADCY7/NDUFAB1/NDUFS6/MAP3K5/NDUFA7/NDUFS3/NDUFS7/COX5B/UQCRQ/PNPLA2/SDHB/UQCRC1/MTOR/COX7A2/RPS6KB2/NDUFA1/NDUFB7/SMARCE1	23
KEGG	hsa04931	Insulin resistance	13/488	108/8135	0.01225	0.04629	0.02899	CREB3L2/TBC1D4/PIK3R1/NR1H2/NR1H3/PIK3R2/PIK3CB/STAT3/PRKCB/SOCS3/MTOR/RPS6KB2/PTPN11	13
KEGG	hsa04012	ErbB signaling pathway	11/488	85/8135	0.01226	0.04629	0.02899	MAPK3/PRKCA/PIK3R1/PIK3R2/PIK3CB/PRKCB/MTOR/BAD/RPS6KB2/MAP2K4/NCK1	11
KEGG	hsa04360	Axon guidance	19/488	182/8135	0.01271	0.04702	0.02945	MAPK3/PRKCA/UNC5B/CXCL12/EPHB2/PIK3R1/EPHB4/NRP1/MET/PIK3R2/ABLIM1/PIK3CB/RASA1/PLXNC1/EPHB6/PTPN11/TRPC6/NCK1/ITGB1	19
KEGG	hsa05215	Prostate cancer	12/488	97/8135	0.01285	0.04702	0.02945	MAPK3/CREB3L2/TCF7L2/PIK3R1/PDGFA/PIK3R2/PIK3CB/MTOR/BAD/BCL2/CASP9/CREBBP	12
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/488	16/8135	0.01306	0.04702	0.02945	GGT5/FMO1/FMO3/FMO2	4
KEGG	hsa00071	Fatty acid degradation	7/488	43/8135	0.01314	0.04702	0.02945	ECI1/ADH1C/HADH/ADH1A/ADH1B/ALDH2/ALDH7A1	7
KEGG	hsa04911	Insulin secretion	11/488	86/8135	0.01332	0.04702	0.02945	CREB3L2/PRKCA/ADCY8/ADCY7/ITPR3/KCNN4/ATP1B1/PRKCB/KCNMB1/PLCB1/CACNA1C	11
KEGG	hsa04918	Thyroid hormone synthesis	10/488	75/8135	0.01358	0.04702	0.02945	CREB3L2/PRKCA/ADCY8/ADCY7/HSPA5/ITPR3/ATP1B1/GPX3/PRKCB/PLCB1	10
KEGG	hsa05214	Glioma	10/488	75/8135	0.01358	0.04702	0.02945	MAPK3/PRKCA/PIK3R1/PDGFA/PIK3R2/PIK3CB/PRKCB/MTOR/CDKN2A/CAMK1	10
KEGG	hsa01522	Endocrine resistance	12/488	98/8135	0.01388	0.04702	0.02945	MAPK3/ADCY8/PIK3R1/ADCY7/PIK3R2/PIK3CB/NOTCH3/MTOR/BAD/RPS6KB2/BCL2/CDKN2A	12
KEGG	hsa05231	Choline metabolism in cancer	12/488	98/8135	0.01388	0.04702	0.02945	MAPK3/PRKCA/PLA2G4C/PIK3R1/HIF1A/PDGFA/PIK3R2/PIK3CB/PRKCB/MTOR/RPS6KB2/PIP5K1A	12
KEGG	hsa04141	Protein processing in endoplasmic reticulum	18/488	171/8135	0.01392	0.04702	0.02945	CRYAB/RRBP1/SEL1L/RAD23A/NSFL1C/HSPA5/SSR2/HSPA2/UBE2G1/MAP3K5/UBE2J1/SEC13/BAG1/BCL2/MBTPS1/SEC23B/LMAN1/STT3A	18
KEGG	hsa04270	Vascular smooth muscle contraction	15/488	134/8135	0.01411	0.04716	0.02954	MAPK3/PRKCA/ADCY8/RAMP2/PLA2G4C/ADCY7/MYH9/MYLK/ITPR3/PRKCB/KCNMB1/PLCB1/CACNA1C/EDNRA/ACTA2	15
KEGG	hsa05220	Chronic myeloid leukemia	10/488	76/8135	0.01483	0.04907	0.03073	MAPK3/TGFBR1/PIK3R1/BCL2L1/PIK3R2/PIK3CB/TGFB2/BAD/PTPN11/CDKN2A	10
KEGG	hsa04072	Phospholipase D signaling pathway	16/488	148/8135	0.01564	0.05079	0.03181	MAPK3/PRKCA/ADCY8/PLA2G4C/PIK3R1/ADCY7/PDGFA/PIK3R2/PIK3CB/LPAR1/MTOR/CYTH1/PLCB1/AGPAT1/PIP5K1A/PTPN11	16
KEGG	hsa04540	Gap junction	11/488	88/8135	0.01566	0.05079	0.03181	MAPK3/PRKCA/ADCY8/GJA1/ADCY7/ITPR3/PDGFA/PRKCB/LPAR1/PLCB1/HTR2B	11
KEGG	hsa05226	Gastric cancer	16/488	149/8135	0.01659	0.05327	0.03336	MAPK3/TCF7L2/FZD7/TGFBR1/PIK3R1/FZD2/MET/FZD6/PIK3R2/PIK3CB/TGFB2/WNT11/MTOR/RPS6KB2/BCL2/FZD1	16
KEGG	hsa00010	Glycolysis / Gluconeogenesis	9/488	67/8135	0.0179	0.05667	0.03549	ADH1C/LDHA/FBP1/ADH1A/ADH1B/ALDH2/PGM1/TPI1/ALDH7A1	9
KEGG	hsa05169	Epstein-Barr virus infection	20/488	202/8135	0.01839	0.05667	0.03549	PSMD8/OAS1/ISG15/OAS2/PIK3R1/PSMD1/CCND2/PIK3R2/HLA-DRB4/PIK3CB/STAT3/HLA-DQB1/IRF7/BCL2/MAP2K4/PSMD3/CASP9/TAP1/PSMD2/HLA-DPB1	20
KEGG	hsa04670	Leukocyte transendothelial migration	13/488	114/8135	0.01864	0.05667	0.03549	ACTN1/PRKCA/CXCL12/CLDN4/PIK3R1/ITGB2/PIK3R2/PIK3CB/THY1/PRKCB/PTPN11/EZR/ITGB1	13
KEGG	hsa04724	Glutamatergic synapse	13/488	114/8135	0.01864	0.05667	0.03549	MAPK3/PRKCA/ADCY8/PLA2G4C/ADCY7/GNB5/ITPR3/GNG12/GRIN2B/PRKCB/PLCB1/CACNA1C/GRIN2A	13
KEGG	hsa03050	Proteasome	7/488	46/8135	0.01871	0.05667	0.03549	PSMD8/PSMB7/PSMD1/PSMB6/PSMD3/PSMD2/PSMB8	7
KEGG	hsa04930	Type II diabetes mellitus	7/488	46/8135	0.01871	0.05667	0.03549	MAPK3/PIK3R1/PIK3R2/PIK3CB/SOCS3/MTOR/CACNA1C	7
KEGG	hsa03030	DNA replication	6/488	36/8135	0.01893	0.05678	0.03556	PRIM2/RFC3/POLE3/RPA3/PRIM1/POLD2	6
KEGG	hsa04371	Apelin signaling pathway	15/488	139/8135	0.01918	0.05701	0.03571	MAPK3/ADCY8/TGFBR1/ADCY7/PIK3C3/MYLK/GNB5/ITPR3/GNG12/NOTCH3/MTOR/RPS6KB2/PLCB1/ACTA2/MAP1LC3B	15
KEGG	hsa00480	Glutathione metabolism	8/488	58/8135	0.02153	0.06283	0.03935	GSTO1/IDH2/GGT5/GGCT/GCLM/GPX4/GPX3/RRM2	8
KEGG	hsa05213	Endometrial cancer	8/488	58/8135	0.02153	0.06283	0.03935	MAPK3/TCF7L2/PIK3R1/PIK3R2/PIK3CB/BAD/CASP9/FOXO3	8
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/488	143/8135	0.02416	0.06987	0.04376	MAPK3/FZD7/BMP4/PIK3R1/FZD2/INHBB/FZD6/PIK3R2/PIK3CB/STAT3/KLF4/JAK2/IL6ST/WNT11/FZD1	15
KEGG	hsa04520	Adherens junction	9/488	71/8135	0.02528	0.07245	0.04538	MAPK3/ACTN1/TCF7L2/TGFBR1/IQGAP1/SNAI2/MET/PTPRB/CREBBP	9
KEGG	hsa04390	Hippo signaling pathway	16/488	157/8135	0.02587	0.07297	0.0457	TCF7L2/FZD7/BMP4/TGFBR1/ITGB2/WWTR1/FZD2/CCND2/SNAI2/FZD6/TEAD3/TGFB2/WNT11/PPP2R1A/FZD1/TEAD4	16
KEGG	hsa05416	Viral myocarditis	8/488	60/8135	0.02591	0.07297	0.0457	CD55/ITGB2/HLA-DRB4/LAMA1/HLA-DQB1/SGCA/CASP9/HLA-DPB1	8
KEGG	hsa04728	Dopaminergic synapse	14/488	132/8135	0.02647	0.07388	0.04627	ARNTL/CREB3L2/PRKCA/GNB5/ITPR3/GNG12/ARRB2/GRIN2B/PRKCB/PLCB1/CACNA1C/PPP2R1A/PPP2R5D/GRIN2A	14
KEGG	hsa04659	Th17 cell differentiation	12/488	108/8135	0.02786	0.0771	0.04829	MAPK3/IL1RAP/TGFBR1/HIF1A/HLA-DRB4/STAT3/JAK2/IL6ST/IL4R/MTOR/HLA-DQB1/HLA-DPB1	12
KEGG	hsa05144	Malaria	7/488	50/8135	0.02847	0.0781	0.04892	THBS4/THBS1/COMP/IL12A/ITGB2/MET/TGFB2	7
KEGG	hsa04925	Aldosterone synthesis and secretion	11/488	98/8135	0.0322	0.08759	0.05486	CREB3L2/PRKCA/ADCY8/ADCY7/PRKD1/ITPR3/ATP1B1/PRKCB/PLCB1/CACNA1C/CAMK1	11
KEGG	hsa05417	Lipid and atherosclerosis	20/488	215/8135	0.03323	0.08963	0.05614	MAPK3/PRKCA/ABCG1/PIK3R1/HSPA5/IL12A/BCL2L1/HSPA2/MAP3K5/PIK3R2/PIK3CB/STAT3/JAK2/IRF7/BAD/BCL2/MAP2K4/PLCB1/CASP9/VLDLR	20
KEGG	hsa00770	Pantothenate and CoA biosynthesis	4/488	21/8135	0.0339	0.09069	0.0568	ENPP1/ALDH2/COASY/BCAT2	4
KEGG	hsa04640	Hematopoietic cell lineage	11/488	99/8135	0.03435	0.09113	0.05708	CD55/ITGA1/ITGB3/ITGA3/CD24/HLA-DRB4/ITGA6/IL4R/HLA-DQB1/ITGA2/HLA-DPB1	11
KEGG	hsa04915	Estrogen signaling pathway	14/488	138/8135	0.03684	0.09693	0.06071	MAPK3/CREB3L2/ADCY8/PIK3R1/ADCY7/HSPA2/FKBP4/ITPR3/PIK3R2/PIK3CB/GABBR1/BCL2/PLCB1/KRT18	14
KEGG	hsa04971	Gastric acid secretion	9/488	76/8135	0.03725	0.09721	0.06089	PRKCA/ADCY8/ADCY7/MYLK/ITPR3/ATP1B1/PRKCB/PLCB1/EZR	9
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/488	53/8135	0.03772	0.09764	0.06115	VDR/CLTB/PRKCA/ATP1B1/PRKCB/PLCB1/AP2B1	7
KEGG	hsa04062	Chemokine signaling pathway	18/488	192/8135	0.03927	0.09964	0.0624	MAPK3/ADCY8/CXCL12/PIK3R1/ADCY7/CCR3/GNB5/CCR1/PIK3R2/GNG12/PIK3CB/STAT3/ARRB2/JAK2/PRKCB/BAD/PLCB1/FOXO3	18
KEGG	hsa05321	Inflammatory bowel disease	8/488	65/8135	0.0395	0.09964	0.0624	IL18R1/IL12A/HLA-DRB4/STAT3/TGFB2/IL4R/HLA-DQB1/HLA-DPB1	8
KEGG	hsa04211	Longevity regulating pathway	10/488	89/8135	0.03977	0.09964	0.0624	CREB3L2/ADCY8/PIK3R1/ADCY7/PIK3R2/PIK3CB/MTOR/RPS6KB2/CAT/FOXO3	10
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/488	89/8135	0.03977	0.09964	0.0624	MAPK3/PIK3R1/HIF1A/PIK3R2/PIK3CB/STAT3/JAK2/MTOR/RPS6KB2/PTPN11	10
KEGG	hsa05100	Bacterial invasion of epithelial cells	9/488	77/8135	0.04004	0.09964	0.0624	CLTB/PIK3R1/MET/CD2AP/ARPC1B/PIK3R2/PIK3CB/CAV3/ITGB1	9
KEGG	hsa04923	Regulation of lipolysis in adipocytes	7/488	56/8135	0.04875	0.1204	0.07539	ADCY8/ABHD5/PIK3R1/ADCY7/PIK3R2/PIK3CB/PNPLA2	7
KEGG	hsa02010	ABC transporters	6/488	45/8135	0.05049	0.1237	0.0775	ABCA3/ABCG1/ABCC4/DEFB1/TAP1/ABCC10	6
KEGG	hsa04071	Sphingolipid signaling pathway	12/488	119/8135	0.05276	0.1273	0.07976	MAPK3/PRKCA/PIK3R1/MAP3K5/PIK3R2/PIK3CB/PRKCB/ASAH1/BCL2/PLCB1/PPP2R1A/PPP2R5D	12
KEGG	hsa04722	Neurotrophin signaling pathway	12/488	119/8135	0.05276	0.1273	0.07976	MAPK3/MAGED1/NTRK2/PIK3R1/MAP3K5/PIK3R2/PIK3CB/RAPGEF1/BAD/BCL2/PTPN11/FOXO3	12
KEGG	hsa03420	Nucleotide excision repair	6/488	47/8135	0.06029	0.1434	0.08979	RAD23A/RFC3/POLE3/RPA3/POLD2/XPC	6
KEGG	hsa04973	Carbohydrate digestion and absorption	6/488	47/8135	0.06029	0.1434	0.08979	PIK3R1/PIK3R2/PIK3CB/ATP1B1/PRKCB/PLCB1	6
KEGG	hsa00350	Tyrosine metabolism	5/488	36/8135	0.06179	0.1458	0.09135	ADH1C/ADH1A/ADH1B/TYR/FAH	5
KEGG	hsa04014	Ras signaling pathway	20/488	232/8135	0.06418	0.1504	0.09418	MAPK3/PRKCA/ANGPT1/NTRK2/PLA2G4C/PIK3R1/VEGFC/BCL2L1/GNB5/MET/PDGFA/PIK3R2/GNG12/PIK3CB/RASA1/GRIN2B/PRKCB/BAD/PTPN11/GRIN2A	20
KEGG	hsa00982	Drug metabolism - cytochrome P450	8/488	72/8135	0.06544	0.1508	0.09442	GSTO1/ADH1C/FMO1/FMO3/CYP3A4/ADH1A/ADH1B/FMO2	8
KEGG	hsa05218	Melanoma	8/488	72/8135	0.06544	0.1508	0.09442	MAPK3/PIK3R1/MET/PDGFA/PIK3R2/PIK3CB/BAD/CDKN2A	8
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	14/488	150/8135	0.06575	0.1508	0.09442	MAPK3/CREB3L2/TPM2/PRKCA/ADCY8/ATP2A2/ADCY7/TPM1/ATP1B1/BCL2/PLCB1/CACNA1C/PPP2R1A/PPP2R5D	14
KEGG	hsa04730	Long-term depression	7/488	60/8135	0.06636	0.1511	0.09462	MAPK3/PRKCA/PLA2G4C/ITPR3/PRKCB/PLCB1/PPP2R1A	7
KEGG	hsa04115	p53 signaling pathway	8/488	73/8135	0.06985	0.1579	0.09889	THBS1/BCL2L1/CCND2/RRM2/BCL2/CASP9/RCHY1/CDKN2A	8
KEGG	hsa04024	cAMP signaling pathway	19/488	221/8135	0.07141	0.1603	0.1004	MAPK3/CREB3L2/ADCY8/ATP2A2/PIK3R1/ADCY7/ABCC4/PDE4B/PIK3R2/PIK3CB/ATP1B1/CNGA3/GABBR1/GRIN2B/BAD/CACNA1C/EDNRA/GRIN2A/CREBBP	19
KEGG	hsa05418	Fluid shear stress and atherosclerosis	13/488	139/8135	0.07336	0.1635	0.1024	GSTO1/TXN/BMP4/PIK3R1/MAP3K5/ITGB3/PDGFA/PIK3R2/PIK3CB/CAV3/BCL2/MAP2K4/SDC4	13
KEGG	hsa04144	Endocytosis	21/488	251/8135	0.07567	0.1635	0.1024	STAM/SH3GL2/CLTB/FOLR3/FOLR2/TGFBR1/ARF4/HSPA2/CAPZA2/ARPC1B/CAV3/ARRB2/ARFGAP2/RAB8A/CHMP2A/TSG101/CYTH1/AP2B1/BIN1/PIP5K1A/VPS45	21
KEGG	hsa04010	MAPK signaling pathway	24/488	294/8135	0.0757	0.1635	0.1024	MAPK3/MAPKAPK3/MAP3K4/PRKCA/IL1RAP/ANGPT1/NTRK2/TGFBR1/PLA2G4C/VEGFC/HSPA2/MAP3K5/MET/PDGFA/GNG12/FLNB/MAP4K2/TGFB2/RASA1/ARRB2/PRKCB/DUSP7/MAP2K4/CACNA1C	24
KEGG	hsa04022	cGMP-PKG signaling pathway	15/488	167/8135	0.07584	0.1635	0.1024	MAPK3/CREB3L2/ADCY8/ATP2A2/ADCY7/MYLK/ITPR3/ATP1B1/RGS2/BAD/KCNMB1/PLCB1/CACNA1C/EDNRA/TRPC6	15
KEGG	hsa04310	Wnt signaling pathway	15/488	167/8135	0.07584	0.1635	0.1024	SFRP4/TCF7L2/PRKCA/FZD7/FZD2/CCND2/GPC4/FZD6/TLE4/PRKCB/WNT11/ROR2/PLCB1/FZD1/CREBBP	15
KEGG	hsa04260	Cardiac muscle contraction	9/488	87/8135	0.07588	0.1635	0.1024	TPM2/ATP2A2/TPM1/COX5B/UQCRQ/ATP1B1/UQCRC1/COX7A2/CACNA1C	9
KEGG	hsa05206	MicroRNAs in cancer	25/488	310/8135	0.07919	0.1695	0.1061	MAPK3/THBS1/CYP1B1/PRKCA/PIK3R1/CCND2/TPM1/MET/ITGB3/PDGFA/FSCN1/PIK3R2/PIK3CB/STAT3/TGFB2/NOTCH3/PRKCB/UBE2I/MTOR/BCL2/TNC/SOX4/EZR/CDKN2A/CREBBP	25
KEGG	hsa04934	Cushing syndrome	14/488	155/8135	0.08134	0.1727	0.1082	MAPK3/CREB3L2/TCF7L2/ADCY8/FZD7/ADCY7/FZD2/ITPR3/FZD6/WNT11/PLCB1/CACNA1C/FZD1/CDKN2A	14
KEGG	hsa05217	Basal cell carcinoma	7/488	63/8135	0.08178	0.1727	0.1082	TCF7L2/FZD7/BMP4/FZD2/FZD6/WNT11/FZD1	7
KEGG	hsa00330	Arginine and proline metabolism	6/488	51/8135	0.08304	0.1742	0.1091	PYCR1/P4HA1/CKB/CKMT2/ALDH2/ALDH7A1	6
KEGG	hsa05142	Chagas disease	10/488	102/8135	0.08452	0.1754	0.1099	MAPK3/TGFBR1/PIK3R1/IL12A/PIK3R2/PIK3CB/TGFB2/MAP2K4/PLCB1/PPP2R1A	10
KEGG	hsa04727	GABAergic synapse	9/488	89/8135	0.08484	0.1754	0.1099	TRAK2/PRKCA/ADCY8/ADCY7/GNB5/GNG12/GABBR1/PRKCB/CACNA1C	9
KEGG	hsa05170	Human immunodeficiency virus 1 infection	18/488	212/8135	0.08525	0.1754	0.1099	MAPK3/PRKCA/APOBEC3B/PIK3R1/BCL2L1/GNB5/ITPR3/PIK3R2/GNG12/PIK3CB/APOBEC3C/PRKCB/MTOR/BAD/RPS6KB2/BCL2/CASP9/TAP1	18
KEGG	hsa04392	Hippo signaling pathway - multiple species	4/488	29/8135	0.09273	0.1896	0.1188	WWTR1/RASSF2/TEAD3/TEAD4	4
KEGG	hsa04068	FoxO signaling pathway	12/488	131/8135	0.09358	0.1896	0.1188	MAPK3/TGFBR1/PIK3R1/CCND2/PRMT1/PIK3R2/PIK3CB/STAT3/TGFB2/CAT/FOXO3/CREBBP	12
KEGG	hsa05032	Morphine addiction	9/488	91/8135	0.09442	0.1896	0.1188	PRKCA/ADCY8/ADCY7/PDE4B/GNB5/GNG12/ARRB2/GABBR1/PRKCB	9
KEGG	hsa04612	Antigen processing and presentation	8/488	78/8135	0.09451	0.1896	0.1188	HSPA5/HSPA2/HLA-DRB4/RFX5/HLA-DQB1/TAP1/NFYB/HLA-DPB1	8
KEGG	hsa04658	Th1 and Th2 cell differentiation	9/488	92/8135	0.09943	0.1982	0.1242	MAPK3/MAML1/IL12A/HLA-DRB4/NOTCH3/JAK2/IL4R/HLA-DQB1/HLA-DPB1	9
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	3/488	19/8135	0.1018	0.1984	0.1243	IDH2/ACO2/BCAT2	3
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	4/488	30/8135	0.1022	0.1984	0.1243	PCCB/ACO2/CAT/MDH2	4
KEGG	hsa01523	Antifolate resistance	4/488	30/8135	0.1022	0.1984	0.1243	FOLR3/FOLR2/ABCC4/GART	4
KEGG	hsa05224	Breast cancer	13/488	147/8135	0.1027	0.1984	0.1243	MAPK3/TCF7L2/FZD7/PIK3R1/FZD2/FZD6/PIK3R2/PIK3CB/NOTCH3/WNT11/MTOR/RPS6KB2/FZD1	13
KEGG	hsa05131	Shigellosis	20/488	247/8135	0.1045	0.1984	0.1243	MAPK3/ACTN1/RRAGD/PIK3R1/BCL2L1/PIK3C3/DIAPH1/ITPR3/ARPC1B/PIK3R2/PIK3CB/CAPNS1/MTOR/RPS6KB2/BCL2/CYTH1/PLCB1/MAP1LC3B/FOXO3/ITGB1	20
KEGG	hsa04970	Salivary secretion	9/488	93/8135	0.1046	0.1984	0.1243	PRKCA/ADCY8/ADCY7/ITPR3/KCNN4/BST1/ATP1B1/PRKCB/PLCB1	9
KEGG	hsa00380	Tryptophan metabolism	5/488	42/8135	0.1046	0.1984	0.1243	CYP1B1/HADH/ALDH2/CAT/ALDH7A1	5
KEGG	hsa04152	AMPK signaling pathway	11/488	120/8135	0.1049	0.1984	0.1243	CREB3L2/PIK3R1/FBP1/PIK3R2/PIK3CB/RAB8A/MTOR/RPS6KB2/PPP2R1A/PPP2R5D/FOXO3	11
KEGG	hsa05203	Viral carcinogenesis	17/488	204/8135	0.1051	0.1984	0.1243	MAPK3/ACTN1/CREB3L2/ATP6V0D1/PIK3R1/KAT2B/CCND2/CCR3/GSN/PIK3R2/PIK3CB/STAT3/IL6ST/IRF7/BAD/CDKN2A/CREBBP	17
KEGG	hsa04664	Fc epsilon RI signaling pathway	7/488	68/8135	0.1117	0.2097	0.1313	MAPK3/PRKCA/PLA2G4C/PIK3R1/PIK3R2/PIK3CB/MAP2K4	7
KEGG	hsa03013	Nucleocytoplasmic transport	10/488	108/8135	0.1127	0.2102	0.1317	THOC1/PNN/RANGAP1/NUP205/NUP93/NUP153/SEC13/UBE2I/SAP18/KPNA3	10
KEGG	hsa00100	Steroid biosynthesis	3/488	20/8135	0.1147	0.2111	0.1322	TM7SF2/LBR/LIPA	3
KEGG	hsa00670	One carbon pool by folate	3/488	20/8135	0.1147	0.2111	0.1322	MTHFD2/GART/MTHFD1	3
KEGG	hsa04210	Apoptosis	12/488	136/8135	0.1151	0.2111	0.1322	MAPK3/CTSC/HRK/PIK3R1/BCL2L1/MAP3K5/ITPR3/PIK3R2/PIK3CB/BAD/BCL2/CASP9	12
KEGG	hsa05150	Staphylococcus aureus infection	9/488	96/8135	0.121	0.2206	0.1382	FPR1/ITGB2/C1S/DEFB1/HLA-DRB4/C1R/HLA-DQB1/KRT18/HLA-DPB1	9
KEGG	hsa04136	Autophagy - other	4/488	32/8135	0.1224	0.2219	0.139	ATG2A/PIK3C3/MTOR/ATG4A	4
KEGG	hsa04668	TNF signaling pathway	10/488	112/8135	0.134	0.2417	0.1514	MAPK3/IL18R1/CREB3L2/PIK3R1/VEGFC/MAP3K5/PIK3R2/PIK3CB/SOCS3/MAP2K4	10
KEGG	hsa01232	Nucleotide metabolism	8/488	85/8135	0.1363	0.2445	0.1531	ENPP1/NME3/AK1/TK2/GUK1/RRM2/GMPR/CTPS1	8
KEGG	hsa03020	RNA polymerase	4/488	34/8135	0.1441	0.257	0.1609	POLR2L/POLR2E/POLR3D/POLR3G	4
KEGG	hsa00230	Purine metabolism	11/488	128/8135	0.1452	0.2575	0.1613	ENPP1/NME3/AK1/ADCY8/ADCY7/PDE4B/GUK1/GART/RRM2/GMPR/PGM1	11
KEGG	hsa01200	Carbon metabolism	10/488	115/8135	0.1514	0.2655	0.1663	IDH2/PCCB/ACO2/SDHA/OGDH/FBP1/SDHB/CAT/TPI1/MDH2	10
KEGG	hsa04726	Serotonergic synapse	10/488	115/8135	0.1514	0.2655	0.1663	MAPK3/PRKCA/PLA2G4C/GNB5/ITPR3/GNG12/PRKCB/PLCB1/CACNA1C/HTR2B	10
KEGG	hsa03430	Mismatch repair	3/488	23/8135	0.1566	0.2724	0.1706	RFC3/RPA3/POLD2	3
KEGG	hsa05171	Coronavirus disease - COVID-19	18/488	232/8135	0.157	0.2724	0.1706	MAPK3/PRKCA/OAS1/ISG15/OAS2/PIK3R1/ADAR/IL12A/C1S/NRP1/PIK3R2/PIK3CB/STAT3/C1R/IL6ST/PRKCB/MX1/MX2	18
KEGG	hsa04672	Intestinal immune network for IgA production	5/488	49/8135	0.1686	0.2909	0.1822	CXCL12/HLA-DRB4/TNFRSF17/HLA-DQB1/HLA-DPB1	5
KEGG	hsa04623	Cytosolic DNA-sensing pathway	6/488	63/8135	0.175	0.3004	0.1881	POLR2L/POLR2E/ADAR/POLR3D/POLR3G/IRF7	6
KEGG	hsa05143	African trypanosomiasis	4/488	37/8135	0.1792	0.306	0.1916	PRKCA/IL12A/PRKCB/PLCB1	4
KEGG	hsa05330	Allograft rejection	4/488	38/8135	0.1915	0.3252	0.2037	IL12A/HLA-DRB4/HLA-DQB1/HLA-DPB1	4
KEGG	hsa04927	Cortisol synthesis and secretion	6/488	65/8135	0.1933	0.3266	0.2045	CREB3L2/ADCY8/ADCY7/ITPR3/PLCB1/CACNA1C	6
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/488	14/8135	0.2036	0.3421	0.2143	B4GALT2/CHST2	2
KEGG	hsa01240	Biosynthesis of cofactors	12/488	153/8135	0.207	0.3461	0.2168	NADK/NME3/MTHFD2/AK1/UROS/GCLM/MTHFD1/ALDH2/COASY/FLAD1/BCAT2/CTPS1	12
KEGG	hsa04921	Oxytocin signaling pathway	12/488	154/8135	0.2132	0.3546	0.2221	MAPK3/PRKCA/ADCY8/PLA2G4C/ADCY7/MYLK/ITPR3/RGS2/PRKCB/PLCB1/CACNA1C/CAMK1	12
KEGG	hsa00062	Fatty acid elongation	3/488	27/8135	0.2183	0.3613	0.2263	ELOVL2/HADH/TECR	3
KEGG	hsa05031	Amphetamine addiction	6/488	69/8135	0.2319	0.3818	0.2391	CREB3L2/PRKCA/GRIN2B/PRKCB/CACNA1C/GRIN2A	6
KEGG	hsa00564	Glycerophospholipid metabolism	8/488	98/8135	0.2337	0.3821	0.2393	PLA2G15/LPGAT1/PCYT2/PLA2G4C/CDS1/CDS2/GPD1L/AGPAT1	8
KEGG	hsa00650	Butanoate metabolism	3/488	28/8135	0.2345	0.3821	0.2393	OXCT1/HMGCL/HADH	3
KEGG	hsa05132	Salmonella infection	18/488	249/8135	0.2375	0.3851	0.2412	MAPK3/PLEKHM1/VPS41/TCF7L2/TXN/PIK3C3/VPS11/PODXL/ARPC1B/DYNC1I1/FLNB/PIK3CB/BCL2/PLEKHM2/MAP2K4/CYTH1/PKN1/KPNA3	18
KEGG	hsa04940	Type I diabetes mellitus	4/488	43/8135	0.2563	0.4134	0.259	IL12A/HLA-DRB4/HLA-DQB1/HLA-DPB1	4
KEGG	hsa00240	Pyrimidine metabolism	5/488	58/8135	0.2671	0.4287	0.2685	ENPP1/NME3/TK2/RRM2/CTPS1	5
KEGG	hsa04020	Calcium signaling pathway	17/488	240/8135	0.2724	0.4351	0.2725	PRKCA/ADCY8/ATP2A2/NTRK2/VEGFC/ADCY7/MYLK/MET/ITPR3/PDGFA/PRKCB/PLCB1/CACNA1C/HTR2B/EDNRA/GRIN2A/CAMK1	17
KEGG	hsa04330	Notch signaling pathway	5/488	59/8135	0.2788	0.4431	0.2775	MAML1/KAT2B/TLE4/NOTCH3/CREBBP	5
KEGG	hsa05310	Asthma	3/488	31/8135	0.284	0.4491	0.2813	HLA-DRB4/HLA-DQB1/HLA-DPB1	3
KEGG	hsa04215	Apoptosis - multiple species	3/488	32/8135	0.3007	0.4732	0.2964	BCL2L1/BCL2/CASP9	3
KEGG	hsa05133	Pertussis	6/488	76/8135	0.3043	0.4765	0.2985	MAPK3/IL12A/ITGB2/C1S/C1R/ITGB1	6
KEGG	hsa04910	Insulin signaling pathway	10/488	137/8135	0.3067	0.4779	0.2993	MAPK3/PIK3R1/FBP1/PIK3R2/PIK3CB/RAPGEF1/SOCS3/MTOR/BAD/RPS6KB2	10
KEGG	hsa00531	Glycosaminoglycan degradation	2/488	19/8135	0.317	0.4876	0.3054	NAGLU/IDS	2
KEGG	hsa00051	Fructose and mannose metabolism	3/488	33/8135	0.3175	0.4876	0.3054	SORD/FBP1/TPI1	3
KEGG	hsa03410	Base excision repair	3/488	33/8135	0.3175	0.4876	0.3054	MBD4/POLE3/POLD2	3
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/488	78/8135	0.3258	0.498	0.3119	GSTO1/CYP1B1/ADH1C/CYP3A4/ADH1A/ADH1B	6
KEGG	hsa04218	Cellular senescence	11/488	156/8135	0.3338	0.5079	0.3181	MAPK3/TGFBR1/PIK3R1/CCND2/ITPR3/PIK3R2/PIK3CB/TGFB2/MTOR/FOXO3/CDKN2A	11
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/488	20/8135	0.3395	0.5141	0.322	CHST7/CHSY1	2
KEGG	hsa04120	Ubiquitin mediated proteolysis	10/488	142/8135	0.3467	0.5201	0.3258	UBOX5/UBE2G1/UBE2J1/SOCS3/UBE2I/UBE2E1/ANAPC15/RCHY1/UBA1/RHOBTB2	10
KEGG	hsa04936	Alcoholic liver disease	10/488	142/8135	0.3467	0.5201	0.3258	TCF7L2/ADH1C/IL12A/ADH1A/MAP3K5/ADH1B/MAP2K4/ALDH2/FOXO3/ALDH7A1	10
KEGG	hsa00510	N-Glycan biosynthesis	4/488	50/8135	0.3525	0.5263	0.3296	B4GALT2/ST6GAL1/DPM2/STT3A	4
KEGG	hsa04380	Osteoclast differentiation	9/488	128/8135	0.3608	0.5362	0.3358	MAPK3/TGFBR1/PIK3R1/ITGB3/PIK3R2/PIK3CB/TGFB2/SOCS3/TNFRSF11B	9
KEGG	hsa00270	Cysteine and methionine metabolism	4/488	51/8135	0.3664	0.539	0.3376	LDHA/GCLM/MDH2/BCAT2	4
KEGG	hsa04913	Ovarian steroidogenesis	4/488	51/8135	0.3664	0.539	0.3376	CYP1B1/ADCY8/PLA2G4C/ADCY7	4
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	3/488	36/8135	0.3678	0.539	0.3376	ENPP1/NADK/BST1	3
KEGG	hsa00340	Histidine metabolism	2/488	22/8135	0.3837	0.5597	0.3505	ALDH2/ALDH7A1	2
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	9/488	131/8135	0.3868	0.5597	0.3505	MAPK3/PRKCA/MICB/PIK3R1/ITGB2/PIK3R2/PIK3CB/PRKCB/PTPN11	9
KEGG	hsa00830	Retinol metabolism	5/488	68/8135	0.3871	0.5597	0.3505	ADH1C/CYP3A4/ADH1A/ADH1B/ALDH1A3	5
KEGG	hsa04920	Adipocytokine signaling pathway	5/488	69/8135	0.3992	0.5682	0.3559	STAT3/JAK2/SOCS3/MTOR/PTPN11	5
KEGG	hsa05340	Primary immunodeficiency	3/488	38/8135	0.4009	0.5682	0.3559	RFX5/IGLL1/TAP1	3
KEGG	hsa05130	Pathogenic Escherichia coli infection	13/488	197/8135	0.4021	0.5682	0.3559	MAPK3/CLDN4/MYO10/MYH9/MYO5A/ARPC1B/LPAR1/CYTH1/PTPN11/CASP9/EZR/NCK1/ITGB1	13
KEGG	hsa04514	Cell adhesion molecules	10/488	149/8135	0.404	0.5682	0.3559	CLDN4/ITGB2/HLA-DRB4/MPZL1/ITGA6/HLA-DQB1/VCAN/SDC4/ITGB1/HLA-DPB1	10
KEGG	hsa03060	Protein export	2/488	23/8135	0.4054	0.5682	0.3559	SPCS2/HSPA5	2
KEGG	hsa04614	Renin-angiotensin system	2/488	23/8135	0.4054	0.5682	0.3559	PRCP/CTSA	2
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	2/488	23/8135	0.4054	0.5682	0.3559	SLC4A4/ATP1B1	2
KEGG	hsa04060	Cytokine-cytokine receptor interaction	19/488	295/8135	0.4078	0.5691	0.3565	IL18R1/CXCL12/IL1RAP/BMP4/TGFBR1/CD70/IL12A/TNFRSF14/GHR/INHBB/CCR3/OSMR/CCR1/IL13RA2/TGFB2/TNFRSF17/IL6ST/IL4R/TNFRSF11B	19
KEGG	hsa04622	RIG-I-like receptor signaling pathway	5/488	70/8135	0.4113	0.5715	0.358	PIN1/ISG15/IL12A/TRIM25/IRF7	5
KEGG	hsa04914	Progesterone-mediated oocyte maturation	7/488	102/8135	0.4134	0.5719	0.3582	MAPK3/ADCY8/PIK3R1/ADCY7/PIK3R2/PIK3CB/ANAPC15	7
KEGG	hsa04621	NOD-like receptor signaling pathway	12/488	184/8135	0.4253	0.5852	0.3665	MAPK3/OAS1/TXN/OAS2/BCL2L1/ITPR3/NEK7/IRF7/BCL2/PLCB1/MAP1LC3B/PKN1	12
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/488	24/8135	0.4266	0.5852	0.3665	NDST1/EXT1	2
KEGG	hsa04620	Toll-like receptor signaling pathway	7/488	104/8135	0.4333	0.5894	0.3692	MAPK3/PIK3R1/IL12A/PIK3R2/PIK3CB/IRF7/MAP2K4	7
KEGG	hsa04625	C-type lectin receptor signaling pathway	7/488	104/8135	0.4333	0.5894	0.3692	MAPK3/PIK3R1/IL12A/ITPR3/PIK3R2/PIK3CB/PTPN11	7
KEGG	hsa04340	Hedgehog signaling pathway	4/488	56/8135	0.4354	0.5897	0.3693	CCND2/ARRB2/IQCE/BCL2	4
KEGG	hsa05135	Yersinia infection	9/488	137/8135	0.439	0.5921	0.3708	MAPK3/PIK3R1/ARPC1B/PIK3R2/PIK3CB/MAP2K4/PIP5K1A/PKN1/ITGB1	9
KEGG	hsa04976	Bile secretion	6/488	89/8135	0.4454	0.5965	0.3736	SLC4A4/ADCY8/ADCY7/CYP3A4/ABCC4/ATP1B1	6
KEGG	hsa05134	Legionellosis	4/488	57/8135	0.4489	0.5965	0.3736	IL12A/ITGB2/HSPA2/CASP9	4
KEGG	hsa04216	Ferroptosis	3/488	41/8135	0.4497	0.5965	0.3736	GCLM/GPX4/MAP1LC3B	3
KEGG	hsa05219	Bladder cancer	3/488	41/8135	0.4497	0.5965	0.3736	MAPK3/THBS1/CDKN2A	3
KEGG	hsa04922	Glucagon signaling pathway	7/488	107/8135	0.4631	0.6105	0.3824	CREB3L2/LDHA/FBP1/ITPR3/PRMT1/PLCB1/CREBBP	7
KEGG	hsa05332	Graft-versus-host disease	3/488	42/8135	0.4656	0.6105	0.3824	HLA-DRB4/HLA-DQB1/HLA-DPB1	3
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/488	26/8135	0.4679	0.6105	0.3824	PIGH/DPM2	2
KEGG	hsa00790	Folate biosynthesis	2/488	26/8135	0.4679	0.6105	0.3824	PCBD1/QDPR	2
KEGG	hsa01230	Biosynthesis of amino acids	5/488	75/8135	0.471	0.6122	0.3834	PYCR1/IDH2/ACO2/TPI1/BCAT2	5
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	2/488	27/8135	0.4879	0.6315	0.3955	ELOVL2/TECR	2
KEGG	hsa00561	Glycerolipid metabolism	4/488	61/8135	0.5021	0.6473	0.4054	PNPLA2/AGPAT1/ALDH2/ALDH7A1	4
KEGG	hsa00591	Linoleic acid metabolism	2/488	29/8135	0.5263	0.6735	0.4219	PLA2G4C/CYP3A4	2
KEGG	hsa00310	Lysine degradation	4/488	63/8135	0.5278	0.6735	0.4219	SETD1B/HADH/ALDH2/ALDH7A1	4
KEGG	hsa00983	Drug metabolism - other enzymes	5/488	80/8135	0.5288	0.6735	0.4219	GSTO1/NME3/CYP3A4/TK2/RRM2	5
KEGG	hsa04114	Oocyte meiosis	8/488	131/8135	0.5318	0.6748	0.4226	MAPK3/ESPL1/ADCY8/ADCY7/ITPR3/PPP2R1A/PPP2R5D/ANAPC15	8
KEGG	hsa00030	Pentose phosphate pathway	2/488	30/8135	0.5448	0.6859	0.4296	FBP1/PGM1	2
KEGG	hsa00053	Ascorbate and aldarate metabolism	2/488	30/8135	0.5448	0.6859	0.4296	ALDH2/ALDH7A1	2
KEGG	hsa04146	Peroxisome	5/488	82/8135	0.5511	0.6878	0.4308	IDH2/HMGCL/MPV17/PEX7/CAT	5
KEGG	hsa04662	B cell receptor signaling pathway	5/488	82/8135	0.5511	0.6878	0.4308	MAPK3/PIK3R1/PIK3R2/PIK3CB/PRKCB	5
KEGG	hsa03450	Non-homologous end-joining	1/488	13/8135	0.5528	0.6878	0.4308	XRCC6	1
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/488	100/8135	0.5601	0.6896	0.4319	IL18R1/CXCL12/TNFRSF14/CCR3/CCR1/IL6ST	6
KEGG	hsa00052	Galactose metabolism	2/488	31/8135	0.5628	0.6896	0.4319	B4GALT2/PGM1	2
KEGG	hsa00410	beta-Alanine metabolism	2/488	31/8135	0.5628	0.6896	0.4319	ALDH2/ALDH7A1	2
KEGG	hsa04710	Circadian rhythm	2/488	31/8135	0.5628	0.6896	0.4319	ARNTL/PER2	2
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	3/488	49/8135	0.5704	0.6935	0.4344	RENBP/GNPDA1/PGM1	3
KEGG	hsa05030	Cocaine addiction	3/488	49/8135	0.5704	0.6935	0.4344	CREB3L2/GRIN2B/GRIN2A	3
KEGG	hsa05322	Systemic lupus erythematosus	8/488	136/8135	0.5751	0.6967	0.4364	ACTN1/C1S/HLA-DRB4/C1R/GRIN2B/HLA-DQB1/GRIN2A/HLA-DPB1	8
KEGG	hsa00640	Propanoate metabolism	2/488	32/8135	0.5803	0.7003	0.4386	PCCB/LDHA	2
KEGG	hsa04979	Cholesterol metabolism	3/488	50/8135	0.5843	0.7025	0.44	CYP27A1/PLTP/LIPA	3
KEGG	hsa04613	Neutrophil extracellular trap formation	11/488	190/8135	0.5935	0.7087	0.4439	MAPK3/FPR1/PRKCA/PIK3R1/ITGB2/ITGB3/PIK3R2/PIK3CB/PRKCB/MTOR/PLCB1	11
KEGG	hsa04742	Taste transduction	5/488	86/8135	0.5941	0.7087	0.4439	ADCY8/ITPR3/GABBR1/PLCB1/CACNA1C	5
KEGG	hsa04130	SNARE interactions in vesicular transport	2/488	33/8135	0.5973	0.7087	0.4439	GOSR2/VAMP3	2
KEGG	hsa04064	NF-kappa B signaling pathway	6/488	104/8135	0.599	0.7087	0.4439	CXCL12/BCL2L1/TRIM25/PRKCB/UBE2I/BCL2	6
KEGG	hsa04924	Renin secretion	4/488	69/8135	0.6008	0.7087	0.4439	ITPR3/PLCB1/CACNA1C/EDNRA	4
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/488	15/8135	0.605	0.7087	0.4439	ST3GAL5	1
KEGG	hsa00730	Thiamine metabolism	1/488	15/8135	0.605	0.7087	0.4439	AK1	1
KEGG	hsa05320	Autoimmune thyroid disease	3/488	53/8135	0.6242	0.7287	0.4564	HLA-DRB4/HLA-DQB1/HLA-DPB1	3
KEGG	hsa04137	Mitophagy - animal	4/488	72/8135	0.6346	0.7381	0.4623	BCL2L1/HIF1A/MAP1LC3B/FOXO3	4
KEGG	hsa00500	Starch and sucrose metabolism	2/488	36/8135	0.645	0.7475	0.4682	ENPP1/PGM1	2
KEGG	hsa00120	Primary bile acid biosynthesis	1/488	17/8135	0.651	0.7517	0.4708	CYP27A1	1
KEGG	hsa05216	Thyroid cancer	2/488	37/8135	0.6599	0.7592	0.4755	MAPK3/TCF7L2	2
KEGG	hsa01212	Fatty acid metabolism	3/488	57/8135	0.6733	0.7719	0.4835	ELOVL2/HADH/TECR	3
KEGG	hsa00513	Various types of N-glycan biosynthesis	2/488	39/8135	0.6882	0.7861	0.4924	B4GALT2/STT3A	2
KEGG	hsa04530	Tight junction	9/488	169/8135	0.6922	0.7879	0.4935	ACTN1/CLDN4/MYH9/MAP3K5/ARPC1B/RAB8A/PPP2R1A/EZR/ITGB1	9
KEGG	hsa05033	Nicotine addiction	2/488	40/8135	0.7016	0.7958	0.4984	GRIN2B/GRIN2A	2
KEGG	hsa04978	Mineral absorption	3/488	60/8135	0.7069	0.799	0.5004	VDR/ATOX1/ATP1B1	3
KEGG	hsa03440	Homologous recombination	2/488	41/8135	0.7145	0.8025	0.5026	RPA3/POLD2	2
KEGG	hsa00140	Steroid hormone biosynthesis	3/488	61/8135	0.7175	0.8025	0.5026	CYP1B1/CYP3A4/SULT2B1	3
KEGG	hsa00590	Arachidonic acid metabolism	3/488	61/8135	0.7175	0.8025	0.5026	GGT5/PLA2G4C/GPX3	3
KEGG	hsa05202	Transcriptional misregulation in cancer	10/488	193/8135	0.7295	0.813	0.5092	LMO2/NUPR1/BCL2L1/CCND2/ETV6/MET/TSPAN7/PDGFA/KDM6A/PER2	10
KEGG	hsa00860	Porphyrin metabolism	2/488	43/8135	0.7389	0.8208	0.5141	BLVRB/UROS	2
KEGG	hsa00900	Terpenoid backbone biosynthesis	1/488	22/8135	0.7441	0.8236	0.5158	ICMT	1
KEGG	hsa04962	Vasopressin-regulated water reabsorption	2/488	44/8135	0.7505	0.8278	0.5185	CREB3L2/DYNC1I1	2
KEGG	hsa04660	T cell receptor signaling pathway	5/488	104/8135	0.7559	0.8292	0.5194	MAPK3/PIK3R1/PIK3R2/PIK3CB/NCK1	5
KEGG	hsa04610	Complement and coagulation cascades	4/488	85/8135	0.7588	0.8292	0.5194	CD55/ITGB2/C1S/C1R	4
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/488	23/8135	0.7594	0.8292	0.5194	B4GALT2	1
KEGG	hsa04977	Vitamin digestion and absorption	1/488	24/8135	0.7739	0.841	0.5267	BTD	1
KEGG	hsa04110	Cell cycle	6/488	126/8135	0.7755	0.841	0.5267	ESPL1/CCND2/TGFB2/ANAPC15/CDKN2A/CREBBP	6
KEGG	hsa00514	Other types of O-glycan biosynthesis	2/488	47/8135	0.7825	0.8457	0.5297	B4GALT2/ST6GAL1	2
KEGG	hsa00592	alpha-Linolenic acid metabolism	1/488	25/8135	0.7875	0.8483	0.5313	PLA2G4C	1
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	3/488	69/8135	0.7918	0.85	0.5324	GSTO1/CYP1B1/CYP3A4	3
KEGG	hsa00565	Ether lipid metabolism	2/488	49/8135	0.8017	0.8579	0.5373	PLA2G4C/ENPP2	2
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/488	27/8135	0.8123	0.8663	0.5426	B4GALT2	1
KEGG	hsa03320	PPAR signaling pathway	3/488	75/8135	0.8362	0.8888	0.5567	NR1H3/CYP27A1/PLTP	3
KEGG	hsa03015	mRNA surveillance pathway	4/488	97/8135	0.8419	0.8919	0.5586	PNN/SAP18/PPP2R1A/PPP2R5D	4
KEGG	hsa03018	RNA degradation	3/488	79/8135	0.8611	0.9092	0.5695	EXOSC7/EXOSC2/LSM4	3
KEGG	hsa00040	Pentose and glucuronate interconversions	1/488	34/8135	0.8785	0.924	0.5787	SORD	1
KEGG	hsa05034	Alcoholism	8/488	187/8135	0.8808	0.924	0.5787	MAPK3/CREB3L2/NTRK2/GNB5/SLC29A1/GNG12/GRIN2B/GRIN2A	8
KEGG	hsa05168	Herpes simplex virus 1 infection	24/488	495/8135	0.8895	0.93	0.5825	ZNF189/OAS1/OAS2/PIK3R1/IL12A/BCL2L1/TNFRSF14/ZNF10/ITGB3/PIK3R2/HLA-DRB4/PIK3CB/JAK2/SOCS3/MTOR/HLA-DQB1/IRF7/BAD/BCL2/PTPN11/SRSF7/CASP9/TAP1/HLA-DPB1	24
KEGG	hsa00512	Mucin type O-glycan biosynthesis	1/488	36/8135	0.8927	0.9304	0.5827	ST6GALNAC2	1
KEGG	hsa01250	Biosynthesis of nucleotide sugars	1/488	37/8135	0.8992	0.9341	0.585	PGM1	1
KEGG	hsa00260	Glycine, serine and threonine metabolism	1/488	40/8135	0.9163	0.9488	0.5943	ALDH7A1	1
KEGG	hsa04975	Fat digestion and absorption	1/488	43/8135	0.9306	0.9605	0.6016	AGPAT1	1
KEGG	hsa03040	Spliceosome	5/488	147/8135	0.9455	0.9728	0.6093	THOC1/HSPA2/SYF2/LSM4/SRSF7	5
KEGG	hsa00600	Sphingolipid metabolism	1/488	52/8135	0.9603	0.9844	0.6166	ASAH1	1
KEGG	hsa03460	Fanconi anemia pathway	1/488	54/8135	0.965	0.9844	0.6166	RPA3	1
KEGG	hsa04217	Necroptosis	5/488	159/8135	0.966	0.9844	0.6166	PLA2G4C/STAT3/JAK2/CHMP2A/BCL2	5
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	1/488	66/8135	0.9834	0.999	0.6257	LARS2	1
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	2/488	109/8135	0.9909	1	0.6263	WDR43/NHP2	2
KEGG	hsa04080	Neuroactive ligand-receptor interaction	11/488	353/8135	0.996	1	0.6263	FPR1/GHR/GABBR1/GLRB/GRIN2B/LPAR1/P2RY2/HTR2B/EDNRA/GNRHR/GRIN2A	11
KEGG	hsa04657	IL-17 signaling pathway	1/488	94/8135	0.9971	1	0.6263	MAPK3	1
KEGG	hsa03010	Ribosome	1/488	158/8135	0.9999	1	0.6263	MRPL28	1
KEGG	hsa04740	Olfactory transduction	3/488	440/8135	1	1	0.6263	ARRB2/CNGA3/RGS2	3