ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04142	Lysosome	60/1614	132/8135	1.711e-11	5.716e-09	3.783e-09	MAN2B1/M6PR/TCIRG1/LITAF/CTNS/CTSH/TPP1/CLN3/GGA3/CTSB/GLA/NAGPA/NEU1/CTSZ/ATP6AP1/IDUA/SLC11A1/CTSD/NPC2/LAPTM5/GM2A/ACP5/FUCA2/NAGA/CTSK/CTSL/LAMP3/HYAL4/CTSA/LAMP2/ACP2/ATP6V0B/AP1M1/LAMP1/ARSG/GGA2/CTSC/GUSB/DMXL2/ARSB/NAGLU/CTSO/GNPTG/MANBA/AP4E1/GALC/GAA/CLTCL1/HEXB/SLC11A2/SLC17A5/SCARB2/PLA2G15/AP3S1/GALNS/CD63/AP4M1/PPT1/CLTA/CTSS	60
KEGG	hsa05169	Epstein-Barr virus infection	75/1614	202/8135	5.859e-09	9.784e-07	6.475e-07	DDB2/TAP1/STAT1/TNFAIP3/MYD88/TRAF3/ENTPD3/HLA-A/MAPK13/HLA-F/HLA-C/IRF9/HLA-G/FADD/RIPK1/TLR2/SYK/BAX/TRADD/HLA-DPB1/CD44/LYN/CDKN1A/CXCL10/IKBKG/NFKBIE/CCNE2/PIK3CD/HLA-E/IRAK1/TYK2/HLA-DMB/BTK/HLA-B/HLA-DMA/FAS/CDK4/BLNK/BID/CCND2/E2F3/CCNA2/PDIA3/JAK3/HDAC1/HLA-DRB4/IFNA7/TP53/IFNAR2/IRAK4/CASP9/DDX58/RUNX3/NEDD4/NFKBIA/CCND3/CD40/BAK1/IFNAR1/CCND1/IRF3/HLA-DPA1/TAP2/CD3D/SAP30L/CYCS/AKT1/EIF2AK2/AKT2/BCL2/HLA-DRA/VIM/MAPK12/GADD45A/IRF7	75
KEGG	hsa04141	Protein processing in endoplasmic reticulum	64/1614	171/8135	5.442e-08	6.059e-06	4.01e-06	PDIA4/EDEM1/LMAN2/CKAP4/SSR1/HYOU1/TRAM1/SEC61B/RPN1/RPN2/SEC61A1/DNAJC3/DDOST/SSR4/BAX/HSPH1/SEC24A/SEL1L/UBQLN4/SEC23B/CRYAB/DERL2/MOGS/UBE2J1/UBE2D4/HSP90B1/OS9/HSPA6/DNAJC5/SEC24C/BCAP31/PDIA6/SEC31A/EDEM3/PDIA3/EDEM2/DNAJB11/STT3A/SIL1/GANAB/HSP90AB1/RRBP1/SSR2/PRKCSH/SSR3/P4HB/DERL1/BAK1/HSPA5/RNF5/MAN1A2/CANX/DNAJC10/ERP29/UBXN2A/XBP1/EIF2AK2/ERLEC1/PLAA/BCL2/MAN1B1/DNAJA1/DNAJB2/DNAJC1	64
KEGG	hsa05152	Tuberculosis	65/1614	180/8135	2.034e-07	1.698e-05	1.124e-05	ITGB2/TCIRG1/STAT1/MYD88/MAPK13/IL10RA/FADD/TLR2/SYK/BAX/TRADD/CORO1A/ATP6AP1/HLA-DPB1/CTSD/TLR1/FCER1G/SPHK1/NOD2/TNFRSF1A/IRAK1/HLA-DMB/FCGR3B/HLA-DMA/RIPK2/BID/RAB5C/ITGAX/LAMP2/HLA-DRB4/ATP6V0B/LAMP1/IFNA7/IRAK4/CAMK2B/CASP9/IFNGR1/MRC2/IL18/FCGR1A/MAPK1/CALML6/FCGR2A/HLA-DPA1/ITGAM/IL10RB/CYCS/VDR/PPP3R1/AKT1/CLEC4M/TLR4/AKT2/SPHK2/CD14/TLR6/BCL2/CAMK2G/HLA-DRA/CAMK2A/MAPK12/IRAK2/CTSS/LBP/ARHGEF12	65
KEGG	hsa05417	Lipid and atherosclerosis	74/1614	215/8135	2.758e-07	1.842e-05	1.219e-05	NRAS/PYCARD/APOB/MYD88/TRAF3/CYP1A1/MAPK13/MMP9/VLDLR/NCF2/TLR2/RXRG/VAV3/CYBA/BAX/CCL5/CDC42/LYN/TNFSF10/CXCL8/LY96/IKBKG/CD36/NCF1/PIK3CD/MMP1/TNFRSF1A/HSP90B1/IRAK1/HSPA6/CXCL3/FAS/MMP3/BID/CYBB/CYP2A6/ROCK2/IFNA7/TP53/HSP90AB1/IRAK4/CAMK2B/CASP9/VAV1/MIB1/CXCL1/NFKBIA/CYP2J2/IL18/CD40/MAPK1/CALML6/IRF3/HSPA5/SELE/CYCS/XBP1/RAP1B/PPP3R1/AKT1/TLR4/CCL2/AKT2/PLCB4/FOS/CD14/TLR6/BCL2/CAMK2G/CAMK2A/ABCG1/MAPK12/IRF7/LBP	74
KEGG	hsa04145	Phagosome	56/1614	152/8135	6.707e-07	3.728e-05	2.468e-05	C1R/M6PR/TAP1/ITGB2/TCIRG1/HLA-A/HLA-F/THBS2/ITGB1/SEC61B/HLA-C/HGS/HLA-G/NCF2/TLR2/SEC61A1/CYBA/CORO1A/ATP6AP1/HLA-DPB1/THBS3/MARCO/CD36/NCF1/HLA-E/HLA-DMB/HLA-B/CTSL/ATP6V1A/FCGR3B/HLA-DMA/CYBB/RAB5C/LAMP2/HLA-DRB4/ATP6V0B/ITGA5/LAMP1/MBL2/MSR1/MRC2/FCGR1A/FCGR2A/HLA-DPA1/ITGAM/TAP2/CANX/ATP6V1C1/ATP6V1B2/CLEC4M/TLR4/STX7/CD14/TLR6/HLA-DRA/CTSS	56
KEGG	hsa04936	Alcoholic liver disease	53/1614	142/8135	8.342e-07	3.728e-05	2.468e-05	ADIPOQ/MYD88/TRAF3/IL17RA/PRKAA2/MAPK13/ACOX3/FADD/PRKAB2/RIPK1/C2/TRADD/ACACB/CXCL8/PPARGC1A/LY96/IKBKG/TNFRSF1A/IRAK1/CXCL3/SCD/FAS/C1QB/MLYCD/ADH1C/ADH1B/IFNA7/NOX4/IRAK4/ALDH1B1/C5AR1/FASN/CXCL1/NFKBIA/CAMKK2/CCND1/TRA2A/IRF3/C1QA/SCD5/PRKAG2/ALDH3A2/ACACA/AKT1/C3AR1/TLR4/TCF7L1/AKT2/CD14/LPIN2/MAPK12/PRKAG3/LBP	53
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	40/1614	97/8135	9.944e-07	3.728e-05	2.468e-05	ARPC5/ACTR2/RAC2/AMPH/HCK/VAV3/SYK/ARPC1B/CDC42/LYN/PRKCD/SPHK1/NCF1/PIK3CD/MARCKS/ACTR3/FCGR3B/PLA2G4C/ARPC2/BIN1/PLA2G4F/PTPRC/ARPC3/PRKCB/RPS6KB2/VAV1/CFL2/WASF2/FCGR1A/MAPK1/ARPC4/FCGR2A/AKT1/ASAP1/AKT2/SPHK2/LAT/VASP/MARCKSL1/PLA2G4A	40
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	55/1614	150/8135	1.005e-06	3.728e-05	2.468e-05	PRKACB/SCN7A/PLN/ATP1A2/RPS6KA5/GNAQ/MAPK13/GNAI2/TNNC1/TPM4/SLC8A3/SCN4B/CREB3/MYH7/MYL2/TPM2/ATP1B4/TPM3/CACNA1S/CACNA2D1/GNAI3/CACNG1/ADCY7/PPP1R1A/MYH6/ACTC1/CACNB1/TPM1/MYL3/ATP2A1/ADCY9/ADRA1A/CREB3L2/CAMK2B/SCN1B/KCNE1/PPP1CA/RAPGEF3/ATP1A1/MAPK1/CALML6/CACNA1D/AKT1/AKT2/PLCB4/PPP2R3A/ATP2B1/ATP1B3/ATP1B2/BCL2/CAMK2G/CAMK2A/MAPK12/ATP2B2/PIK3R6	55
KEGG	hsa00510	N-Glycan biosynthesis	25/1614	50/8135	1.649e-06	5.508e-05	3.646e-05	MGAT1/ALG8/RPN1/DPM2/RPN2/MGAT4B/DPAGT1/DDOST/ALG14/FUT8/MOGS/ALG2/DOLK/MGAT4A/MGAT2/STT3A/GANAB/ALG3/SRD5A3/ALG6/MAN2A1/MAN1A2/B4GALT3/ALG1/MAN1B1	25
KEGG	hsa04620	Toll-like receptor signaling pathway	41/1614	104/8135	2.925e-06	8.883e-05	5.879e-05	SPP1/STAT1/MYD88/TRAF3/MAPK13/FADD/RIPK1/TLR2/CCL5/CCL4/CXCL8/TLR1/CXCL10/LY96/IKBKG/PIK3CD/IRAK1/CTSK/CD86/TLR8/CXCL9/IFNA7/CD80/IFNAR2/IRAK4/NFKBIA/CD40/IFNAR1/MAPK1/IRF3/TLR5/AKT1/TLR4/AKT2/FOS/CD14/TLR6/MAPK12/CXCL11/IRF7/LBP	41
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	72/1614	222/8135	4.858e-06	0.0001352	8.95e-05	PRKACB/NRAS/ITGB2/BUB3/HLA-A/SMAD3/HLA-F/MSX2/HLA-C/HLA-G/SLC25A6/CHEK1/BAX/CREB3/HLA-DPB1/CDKN1A/IKBKG/VAC14/MAP3K3/ADCY7/CCNE2/PIK3CD/HLA-E/TNFRSF1A/PTEN/TLN2/SLC25A4/HLA-DMB/ETS1/HLA-B/HLA-DMA/CDK4/CCND2/E2F3/TSPO/PTTG1/CCNA2/JAK3/HLA-DRB4/ZFP36/CDC20/ADCY9/SLC25A5/CSF2/TLN1/TP53/CREB3L2/NFKBIA/CCND3/CD40/CCND1/MAPK1/IL1R1/HLA-DPA1/CANX/CD3D/IL15/CRTC3/EGR2/PPP3R1/BUB1B/SLC2A1/AKT1/TRRAP/KAT2B/AKT2/FOS/HLA-DRA/EGR1/CCNB2/STAT5A/MAD1L1	72
KEGG	hsa05323	Rheumatoid arthritis	37/1614	93/8135	6.874e-06	0.0001766	0.0001169	ITGB2/TCIRG1/TNFSF11/TNFSF13B/TLR2/CCL5/ATP6AP1/HLA-DPB1/CXCL8/TNFSF13/MMP1/ACP5/HLA-DMB/CTSK/CXCL3/CD86/CTSL/ATP6V1A/HLA-DMA/MMP3/HLA-DRB4/ATP6V0B/CD80/CSF2/CXCL6/CXCL1/IL18/HLA-DPA1/ATP6V1C1/ATP6V1B2/IL15/FLT1/TLR4/ANGPT1/CCL2/FOS/HLA-DRA	37
KEGG	hsa05205	Proteoglycans in cancer	67/1614	205/8135	7.731e-06	0.0001839	0.0001217	PRKACB/ERBB4/TWIST1/NRAS/HCLS1/GRB2/FLNC/MAPK13/MMP9/GPC3/ITGB1/HPSE/PLAUR/EZR/TLR2/VAV3/SDC1/CAV3/FZD2/CD44/CDC42/CDKN1A/ANK1/PIK3CD/CTSL/ANK2/FAS/FZD1/ROCK2/LUM/ITGA5/EGFR/FZD4/TP53/MIR10A/PRKCB/IQGAP1/RPS6KB2/CAMK2B/ERBB3/VAV1/FLNA/WNT11/PTPN6/HSPB2/PPP1CA/HIF1A/CCND1/MAPK1/WNT9A/COL1A2/WNT8A/AKT1/TLR4/PTCH1/GAB1/AKT2/CAMK2G/CAMK2A/CD63/PLCE1/MAPK12/CBL/NANOG/WNT8B/MSN/ARHGEF12	67
KEGG	hsa05416	Viral myocarditis	27/1614	60/8135	8.257e-06	0.0001839	0.0001217	ITGB2/RAC2/SGCG/HLA-A/HLA-F/HLA-C/HLA-G/MYH7/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/CD86/MYH6/HLA-DMA/BID/HLA-DRB4/SGCA/CD80/DMD/LAMA2/CASP9/CD40/CCND1/HLA-DPA1/CYCS/HLA-DRA	27
KEGG	hsa05140	Leishmaniasis	32/1614	77/8135	9.785e-06	0.0002043	0.0001352	ITGB2/STAT1/MYD88/MAPK13/ITGB1/NCF2/TLR2/CYBA/HLA-DPB1/NCF1/IRAK1/HLA-DMB/FCGR3B/HLA-DMA/CYBB/EEF1A2/HLA-DRB4/PRKCB/IRAK4/IFNGR1/PTPN6/NFKBIA/FCGR1A/MAPK1/FCGR2A/HLA-DPA1/ITGAM/TLR4/FOS/MARCKSL1/HLA-DRA/MAPK12	32
KEGG	hsa05162	Measles	49/1614	139/8135	1.358e-05	0.0002669	0.0001766	STAT1/TNFAIP3/MYD88/TRAF3/RAB9B/IRF9/FADD/TLR2/ADAR/BAX/TRADD/IKBKG/CCNE2/PIK3CD/IRAK1/TYK2/HSPA6/FAS/CDK4/BID/CCND2/JAK3/IFNA7/CD46/MX2/TP53/IFNAR2/IRAK4/CASP9/DDX58/NFKBIA/CCND3/BAK1/IFNAR1/CCND1/IRF3/CD3D/CYCS/AKT1/EIF2AK2/CLEC4M/TLR4/AKT2/FOS/BCL2/CSNK2B/STAT5A/IRF7/MSN	49
KEGG	hsa04115	p53 signaling pathway	30/1614	73/8135	2.393e-05	0.0004441	0.0002939	DDB2/RRM2/SHISA5/CHEK1/BAX/CDKN1A/GORAB/CCNE2/PMAIP1/PTEN/FAS/CDK4/BID/CCND2/CCNB1/ZMAT3/STEAP3/CDK1/TP53/SESN2/CASP9/MDM4/CCND3/CCND1/PERP/CYCS/BCL2/CCNB2/GADD45A/PPM1D	30
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	62/1614	194/8135	3.619e-05	0.0006362	0.000421	NRAS/MICB/STAT1/TRAF3/HLA-A/PREX1/HCK/MAPK13/HLA-F/HLA-C/IRF9/HLA-G/FADD/CCR5/MICA/SYK/BAX/TRADD/LYN/GNB2/CXCL8/CDKN1A/IKBKG/PIK3CD/HLA-E/TNFRSF1A/TYK2/HLA-B/CXCL3/CD86/FAS/CDK4/BID/E2F3/CCR1/ZFP36/IFNA7/CSF2/TP53/IFNAR2/CASP9/IFNGR1/CXCL1/NFKBIA/HIF1A/BAK1/IFNAR1/CCND1/MAPK1/GNG11/CALML6/IRF3/CYCS/PPP3R1/AKT1/EIF2AK2/TCF7L1/AKT2/FOS/MAPK12/PIK3R6/IRF7	62
KEGG	hsa05164	Influenza A	56/1614	171/8135	3.981e-05	0.0006648	0.00044	PYCARD/STAT1/MYD88/TRAF3/IRF9/FADD/SLC25A6/DNAJC3/ADAR/BAX/TRADD/CCL5/HLA-DPB1/TNFSF10/CXCL8/CXCL10/IKBKG/PIK3CD/TNFRSF1A/TYK2/SLC25A4/HLA-DMB/HLA-DMA/FAS/CDK4/KPNA5/BID/RNASEL/NXT1/HLA-DRB4/SLC25A5/IFNA7/MX2/IFNAR2/PRKCB/IRAK4/CASP9/DDX58/IFNGR1/NFKBIA/CCND3/IL18/BAK1/IFNAR1/MAPK1/IRF3/HLA-DPA1/IL33/CYCS/AKT1/EIF2AK2/TLR4/CCL2/AKT2/HLA-DRA/IRF7	56
KEGG	hsa00513	Various types of N-glycan biosynthesis	19/1614	39/8135	4.676e-05	0.0007437	0.0004922	MGAT1/RPN1/RPN2/MGAT4B/DDOST/ALG14/FUT8/ALG2/MGAT4A/MGAT2/STT3A/ALG3/MAN2A1/MAN1A2/HEXB/B4GALT3/ALG1/B4GALNT3/MAN1B1	19
KEGG	hsa04062	Chemokine signaling pathway	61/1614	192/8135	5.07e-05	0.0007697	0.0005094	PRKACB/NRAS/RAC2/STAT1/CXCL16/GRB2/GNAQ/PREX1/HCK/GNAI2/CXCL13/FGR/CCR5/CXCR4/VAV3/GRK5/CCL5/PRKCZ/CDC42/CCL4/LYN/CCL18/GNB2/CXCL8/GNAI3/CXCL10/IKBKG/PRKCD/NCF1/PARD3/ADCY7/SHC1/PIK3CD/DOCK2/CXCL3/CCR1/JAK3/ROCK2/CXCL9/CXCL14/ADCY9/CCL8/PRKCB/CXCL6/ELMO1/VAV1/CXCL1/NFKBIA/CCL7/MAPK1/GNG11/ARRB2/CCR2/RAP1B/AKT1/CCL2/CCR7/AKT2/PLCB4/CXCL11/PIK3R6	61
KEGG	hsa05145	Toxoplasmosis	40/1614	112/8135	5.878e-05	0.0008272	0.0005474	STAT1/MYD88/MAPK13/GNAI2/ITGB1/IL10RA/TLR2/CCR5/HLA-DPB1/GNAI3/LY96/IKBKG/TNFRSF1A/IRAK1/TYK2/HLA-DMB/HSPA6/HLA-DMA/HLA-DRB4/BIRC3/ALOX5/LAMA2/IRAK4/CASP9/IFNGR1/NFKBIA/CD40/MAPK1/HLA-DPA1/IL10RB/CYCS/AKT1/LAMA3/TLR4/AKT2/SOCS1/BCL2/HLA-DRA/MAPK12/PIK3R6	40
KEGG	hsa05163	Human cytomegalovirus infection	69/1614	225/8135	5.944e-05	0.0008272	0.0005474	PRKACB/NRAS/TAP1/RAC2/GRB2/HLA-A/GNAQ/MAPK13/GNAI2/HLA-F/IL10RA/HLA-C/HLA-G/FADD/RIPK1/CCR5/CXCR4/BAX/TRADD/CREB3/CCL5/CCL4/GNB2/CXCL8/CDKN1A/GNAI3/IKBKG/ADCY7/PIK3CD/GNA12/HLA-E/TNFRSF1A/HLA-B/FAS/CDK4/BID/E2F3/CCR1/EIF4EBP1/PDIA3/ROCK2/ADCY9/IFNA7/EGFR/TP53/PRKCB/CREB3L2/RPS6KB2/CASP9/PDGFRA/PTGER3/NFKBIA/BAK1/CCND1/MAPK1/GNG11/CALML6/IRF3/IL1R1/TAP2/IL10RB/CYCS/PPP3R1/AKT1/CCL2/AKT2/PLCB4/MAPK12/ARHGEF12	69
KEGG	hsa04611	Platelet activation	43/1614	124/8135	7.011e-05	0.0009367	0.00062	PRKACB/GNAQ/MAPK13/GNAI2/FERMT3/ITGB1/SYK/PRKCZ/LYN/FCER1G/GNAI3/ADCY7/PIK3CD/TLN2/BTK/PLA2G4C/MYLK3/MYLK2/ROCK2/PLA2G4F/ADCY9/TLN1/GUCY1A2/LCP2/RASGRP1/TBXAS1/PPP1CA/PRKG1/MAPK1/FCGR2A/COL1A2/MYLK4/RAP1B/AKT1/COL3A1/AKT2/PLCB4/VASP/VAMP8/MAPK12/PIK3R6/PLA2G4A/ARHGEF12	43
KEGG	hsa05165	Human papillomavirus infection	94/1614	331/8135	8.439e-05	0.001084	0.0007175	PRKACB/RELN/NRAS/COL4A5/TCIRG1/SPP1/IRF1/STAT1/TRAF3/GRB2/HLA-A/HLA-F/THBS2/ITGB1/HLA-C/EGF/IRF9/HLA-G/FADD/FZD2/BAX/TRADD/CREB3/PRKCZ/ATP6AP1/COL4A6/CDC42/THBS3/CDKN1A/IKBKG/PARD3/COL6A2/CCNE2/PIK3CD/HEY1/HLA-E/TNFRSF1A/PTEN/TYK2/HLA-B/MAGI1/ATP6V1A/BCAP31/FAS/FZD1/CDK4/TNC/CCND2/EIF4EBP1/CCNA2/HDAC1/ATP6V0B/ITGA5/IFNA7/COL6A3/EGFR/FZD4/MX2/ITGA7/TP53/IFNAR2/ITGA1/LAMA2/CREB3L2/RPS6KB2/COL6A6/WNT11/HEYL/CRB3/CCND3/BAK1/IFNAR1/CCND1/MAPK1/WNT9A/IRF3/COL1A2/WNT8A/TNN/ATP6V1C1/ATP6V1B2/AKT1/TUBG2/LAMA3/EIF2AK2/IBSP/PARD6A/TCF7L1/AKT2/COL4A4/PPP2R3A/CSNK1A1/COL9A1/WNT8B	94
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/1614	20/8135	9.159e-05	0.001133	0.0007499	CHPF2/CHST11/XYLT2/CHST12/CHST14/B4GALT7/CSGALNACT2/B3GAT3/CHSY1/CHST15/B3GALT6/DSE	12
KEGG	hsa05130	Pathogenic Escherichia coli infection	61/1614	197/8135	0.0001159	0.001382	0.0009146	WIPF1/ARPC5/HCLS1/PYCARD/ACTR2/MYD88/MAPK13/ITGB1/FADD/RIPK1/EZR/BAX/TRADD/ARPC1B/MYO5A/SEC24A/CDC42/TNFSF10/CXCL8/IKBKG/GNA12/TNFRSF1A/WIPF3/IRAK1/TMBIM6/ACTR3/SEC24C/MYO1F/FAS/ARPC2/ROCK2/MYO1D/ARPC3/IRAK4/MYO1G/CASP9/CLDN6/PTPN6/NFKBIA/TJP1/IL18/BAK1/WASF2/CLDN8/MAPK1/ARPC4/FCGR2A/IL1R1/CYCS/TMED10/TLR5/CLDN17/TLR4/NCKAP1L/CASP4/FOS/ABI1/CLDN23/MYO5C/MAPK12/ARHGEF12	61
KEGG	hsa04064	NF-kappa B signaling pathway	37/1614	104/8135	0.0001205	0.001388	0.0009186	TNFAIP3/MYD88/TRAF3/BCL2A1/TNFSF11/TNFSF13B/RIPK1/SYK/TRADD/CCL4/LYN/CXCL8/LY96/IKBKG/TNFRSF1A/IRAK1/BTK/EDAR/CXCL3/BLNK/PRKCQ/BIRC3/PRKCB/IRAK4/DDX58/CXCL1/NFKBIA/CD40/IL1R1/CARD10/TLR4/CD14/LAT/BCL2/CSNK2B/GADD45A/LBP	37
KEGG	hsa05161	Hepatitis B	52/1614	162/8135	0.0001328	0.001461	0.0009668	DDB2/NRAS/STAT1/MYD88/TRAF3/GRB2/MAPK13/MMP9/SMAD3/FADD/TLR2/BAX/CREB3/ATP6AP1/CXCL8/CDKN1A/IKBKG/CCNE2/PIK3CD/IRAK1/TYK2/FAS/BID/E2F3/PCNA/CCNA2/JAK3/IFNA7/TP53/PRKCB/IRAK4/CREB3L2/CASP9/DDX58/NFKBIA/IFNAR1/MAPK1/IRF3/CYCS/EGR2/STAT6/AKT1/TLR4/AKT2/FOS/YWHAZ/BCL2/YWHAB/DDX3X/MAPK12/STAT5A/IRF7	52
KEGG	hsa04668	TNF signaling pathway	39/1614	112/8135	0.0001356	0.001461	0.0009668	IRF1/TNFAIP3/RPS6KA5/TRAF3/MAPK13/MMP9/FADD/RIPK1/TRADD/CREB3/CCL5/CXCL10/IKBKG/PIK3CD/NOD2/TNFRSF1A/TNFRSF1B/CXCL3/FAS/MMP3/MLKL/EDN1/BIRC3/CSF2/CXCL6/CREB3L2/RIPK3/CXCL1/NFKBIA/MAPK1/SELE/IL15/BAG4/DAB2IP/AKT1/CCL2/AKT2/FOS/MAPK12	39
KEGG	hsa05133	Pertussis	29/1614	76/8135	0.0001599	0.001669	0.001104	C1R/ITGB2/PYCARD/IRF1/MYD88/MAPK13/GNAI2/ITGB1/C2/CXCL8/GNAI3/LY96/IRAK1/C1QB/ITGA5/C1S/CXCL6/IRAK4/CFL2/MAPK1/CALML6/IRF3/ITGAM/C1QA/TLR4/FOS/CD14/IRF8/MAPK12	29
KEGG	hsa04621	NOD-like receptor signaling pathway	57/1614	184/8135	0.0001892	0.001915	0.001268	PYCARD/STAT1/TNFAIP3/MYD88/TRAF3/MAPK13/TRIP6/IRF9/FADD/RIPK1/RBCK1/CTSB/AIM2/CYBA/TRPV2/CCL5/CXCL8/IKBKG/PRKCD/GBP1/NOD2/TYK2/CXCL3/RIPK2/P2RX7/CYBB/MCU/RNASEL/GBP5/PSTPIP1/BIRC3/IFNA7/CARD6/HSP90AB1/IFNAR2/IRAK4/RIPK3/CXCL1/NFKBIA/IFI16/IL18/SHARPIN/IFNAR1/MAPK1/IRF3/CARD16/DEFA6/TLR4/CCL2/CASP4/PLCB4/CARD8/BCL2/MFN2/MEFV/MAPK12/IRF7	57
KEGG	hsa05135	Yersinia infection	45/1614	137/8135	0.0002051	0.002014	0.001333	WIPF1/ARPC5/PYCARD/ACTR2/RAC2/MYD88/GNAQ/MAPK13/ITGB1/VAV3/RHOG/ARPC1B/CDC42/CXCL8/RPS6KA1/IKBKG/PIK3CD/WIPF3/IRAK1/ACTR3/ARPC2/ROCK2/ITGA5/ARPC3/IRAK4/ELMO1/LCP2/VAV1/NFKBIA/IL18/WASF2/MAPK1/ARPC4/IRF3/FCGR2A/AKT1/TLR4/CCL2/AKT2/FOS/LAT/MEFV/MAPK12/ELMO2/ARHGEF12	45
KEGG	hsa04978	Mineral absorption	24/1614	60/8135	0.0002513	0.002398	0.001587	ATP1A2/SLC8A3/ATP1B4/ATOX1/STEAP1/ATP7A/MT1F/SLC40A1/MT1G/SLC39A4/MT1H/FTL/ATP1A1/STEAP2/VDR/SLC11A2/ATP2B1/ATP1B3/ATP1B2/SLC30A1/FTH1/MT2A/HMOX2/ATP2B2	24
KEGG	hsa05132	Salmonella infection	72/1614	249/8135	0.000313	0.002904	0.001922	M6PR/ARPC5/PYCARD/ACTR2/MYD88/FLNC/MAPK13/SNX18/RAB9B/FADD/FYCO1/RIPK1/TLR2/RHOG/BAX/TRADD/ARPC1B/MYL2/CDC42/TNFSF10/CXCL8/ACBD3/LY96/IKBKG/RALA/PIK3CD/TNFRSF1A/HSP90B1/IRAK1/ACTR3/ARPC2/RIPK2/MLKL/MYLPF/RAB5C/ROCK2/PTPRC/DYNLL1/BIRC3/ARPC3/HSP90AB1/IRAK4/ELMO1/FLNA/VPS39/RIPK3/PFN1/NFKBIA/IL18/BAK1/MAPK1/ARPC4/VPS16/RHOH/CYCS/VPS41/TLR5/AKT1/TLR4/NCKAP1L/TCF7L1/CASP4/AKT2/FOS/CD14/ABI1/TLR6/BCL2/MYL9/MAPK12/PLEKHM2/ELMO2	72
KEGG	hsa05410	Hypertrophic cardiomyopathy	32/1614	90/8135	0.0003433	0.003099	0.002051	SGCG/PRKAA2/ITGB1/DES/TNNC1/TPM4/SLC8A3/PRKAB2/TTN/MYH7/MYL2/TPM2/TPM3/CACNA1S/CACNA2D1/CACNG1/MYH6/ACTC1/CACNB1/TPM1/MYL3/ATP2A1/EDN1/ITGA5/SGCA/DMD/ITGA7/ITGA1/LAMA2/CACNA1D/PRKAG2/PRKAG3	32
KEGG	hsa04920	Adipocytokine signaling pathway	26/1614	69/8135	0.0004327	0.003803	0.002517	ADIPOQ/PRKAA2/PRKAB2/RXRG/PCK2/TRADD/ACACB/PPARGC1A/IKBKG/CD36/NFKBIE/TNFRSF1A/TNFRSF1B/LEP/ACSL3/PRKCQ/NFKBIA/CAMKK2/PRKAG2/ACSL5/SLC2A4/SLC2A1/AKT1/G6PC2/AKT2/PRKAG3	26
KEGG	hsa04670	Leukocyte transendothelial migration	38/1614	114/8135	0.0004492	0.003847	0.002546	ITGB2/RAC2/MAPK13/GNAI2/MMP9/RASSF5/ITGB1/EZR/NCF2/CXCR4/VAV3/CTNNA3/CYBA/MYL2/CDC42/GNAI3/NCF1/PIK3CD/MYLPF/CYBB/THY1/ROCK2/PRKCB/CLDN6/VAV1/CD99/CLDN8/RAPGEF3/RHOH/ITGAM/RAP1B/CLDN17/VASP/MYL9/CLDN23/MAPK12/ACTN1/MSN	38
KEGG	hsa04380	Osteoclast differentiation	41/1614	128/8135	0.0006886	0.005714	0.003782	STAT1/GRB2/MAPK13/TNFSF11/TYROBP/IRF9/NCF2/CYBA/SYK/LILRB2/IKBKG/NCF1/PIK3CD/ACP5/TNFRSF1A/TYK2/BTK/CTSK/FCGR3B/BLNK/OSCAR/IFNAR2/CSF1R/LCP2/CALCR/IFNGR1/LILRB4/NFKBIA/IFNAR1/FCGR1A/MAPK1/FCGR2A/IL1R1/PPP3R1/SQSTM1/AKT1/AKT2/SOCS1/FOS/LILRB1/MAPK12	41
KEGG	hsa04510	Focal adhesion	59/1614	201/8135	0.0007015	0.005714	0.003782	RELN/COL4A5/SPP1/RAC2/GRB2/FLNC/THBS2/ITGB1/EGF/VAV3/CAV3/MYL2/COL4A6/CDC42/THBS3/COL6A2/SHC1/PIK3CD/PTEN/TLN2/TNC/MYLPF/MYLK3/CCND2/MYLK2/ROCK2/ITGA5/BIRC3/COL6A3/EGFR/TLN1/ITGA7/PRKCB/ITGA1/LAMA2/COL6A6/VAV1/FLNA/PDGFRA/CCND3/PPP1CA/CCND1/MAPK1/COL1A2/MYLK4/TNN/FLT1/RAP1B/AKT1/LAMA3/IBSP/AKT2/COL4A4/ZYX/VASP/BCL2/MYL9/COL9A1/ACTN1	59
KEGG	hsa04657	IL-17 signaling pathway	32/1614	94/8135	0.0008206	0.006526	0.004319	IL17D/TNFAIP3/TRAF3/IL17RA/MAPK13/MMP9/FADD/MMP13/TRADD/S100A9/CXCL8/CXCL10/IKBKG/MMP1/HSP90B1/CXCL3/USP25/MMP3/TRAF4/CSF2/HSP90AB1/CXCL6/CXCL1/NFKBIA/MUC5B/CCL7/MAPK1/S100A7/CCL2/FOS/S100A8/MAPK12	32
KEGG	hsa05223	Non-small cell lung cancer	26/1614	72/8135	0.0009181	0.007057	0.004671	DDB2/NRAS/GRB2/RASSF5/EGF/RXRG/BAX/CDKN1A/PIK3CD/CDK4/E2F3/EML4/JAK3/EGFR/TP53/PRKCB/CASP9/RASSF1/BAK1/CCND1/MAPK1/AKT1/AKT2/STK4/STAT5A/GADD45A	26
KEGG	hsa04260	Cardiac muscle contraction	30/1614	87/8135	0.0009297	0.007057	0.004671	ATP1A2/CASQ2/TNNC1/TPM4/SLC8A3/ASPH/TRDN/HRC/MYH7/MYL2/TPM2/ATP1B4/TPM3/CACNA1S/CACNA2D1/CACNG1/COX7A1/MYH6/ACTC1/CACNB1/TPM1/MYL3/ATP2A1/UQCRB/ATP1A1/CACNA1D/COX6A2/ATP1B3/ATP1B2/COX2	30
KEGG	hsa05170	Human immunodeficiency virus 1 infection	61/1614	212/8135	0.001001	0.007433	0.004919	NRAS/TAP1/RAC2/MYD88/HLA-A/APOBEC3B/GNAQ/MAPK13/GNAI2/HLA-F/HLA-C/HLA-G/FADD/RIPK1/TLR2/CCR5/CXCR4/CHEK1/BAX/TRADD/GNB2/GNAI3/IKBKG/CUL5/PIK3CD/HLA-E/TNFRSF1A/TNFRSF1B/IRAK1/HLA-B/SAMHD1/FAS/BID/CCNB1/PDIA3/AP1M1/IFNA7/CDK1/PRKCB/IRAK4/RPS6KB2/CASP9/CFL2/NFKBIA/BAK1/MAPK1/GNG11/CALML6/IRF3/TAP2/CD3D/CYCS/PPP3R1/AKT1/TLR4/AKT2/FOS/TRIM5/BCL2/MAPK12/CCNB2	61
KEGG	hsa04512	ECM-receptor interaction	30/1614	88/8135	0.001148	0.008335	0.005516	CD47/RELN/COL4A5/SPP1/FRAS1/THBS2/ITGB1/SDC1/CD44/COL4A6/THBS3/HMMR/CD36/COL6A2/FREM2/NPNT/TNC/ITGA5/COL6A3/ITGA7/ITGA1/LAMA2/COL6A6/COL1A2/TNN/LAMA3/IBSP/COL4A4/COL9A1/DSPP	30
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1614	100/8135	0.00126	0.008955	0.005927	NRAS/COL4A5/STAT1/MAPK13/SMAD3/BAX/PRKCZ/COL4A6/CDC42/CXCL8/PRKCD/PIK3CD/CDK4/CYBB/EDN1/NOX4/PRKCB/PLCD4/CCND1/MAPK1/SELE/COL1A2/AKT1/COL3A1/CCL2/AKT2/PLCB4/COL4A4/BCL2/EGR1/PLCE1/MAPK12/STAT5A	33
KEGG	hsa04210	Apoptosis	42/1614	136/8135	0.001352	0.009406	0.006225	NRAS/LMNB2/CTSH/BCL2A1/FADD/RIPK1/CTSB/BAX/CTSZ/TRADD/LMNB1/CTSD/TNFSF10/CSF2RB/IKBKG/PIK3CD/PMAIP1/TNFRSF1A/CTSK/CTSL/FAS/BID/PARP4/BIRC3/CTSC/TP53/HTRA2/CASP9/CTSO/NFKBIA/BAK1/MAPK1/CYCS/DFFB/DAB2IP/AKT1/AKT2/FOS/MCL1/BCL2/GADD45A/CTSS	42
KEGG	hsa05330	Allograft rejection	16/1614	38/8135	0.00139	0.009414	0.006231	HLA-A/HLA-F/HLA-C/HLA-G/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/CD86/HLA-DMA/FAS/HLA-DRB4/CD80/CD40/HLA-DPA1/HLA-DRA	16
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	30/1614	89/8135	0.001409	0.009414	0.006231	NRAS/STAT1/MYD88/MAPK13/EGF/TLR2/IKBKG/MAP3K3/NFKBIE/PIK3CD/PTEN/EML4/PRKCQ/EGFR/RPS6KB2/RASGRP1/IFNGR1/PTPN6/NFKBIA/HIF1A/MAPK1/CD3D/PPP3R1/AKT1/TLR4/AKT2/FOS/LAT/CSNK2B/MAPK12	30
KEGG	hsa04662	B cell receptor signaling pathway	28/1614	82/8135	0.001608	0.01053	0.006968	NRAS/RAC2/GRB2/PIK3AP1/VAV3/DAPP1/SYK/LILRB2/LYN/IKBKG/NFKBIE/PIK3CD/BTK/BLNK/CD72/CD81/PRKCB/VAV1/LILRB4/PTPN6/NFKBIA/IFITM1/MAPK1/PPP3R1/AKT1/AKT2/FOS/LILRB1	28
KEGG	hsa04921	Oxytocin signaling pathway	46/1614	154/8135	0.001766	0.01125	0.007448	PRKACB/NRAS/GNAQ/PRKAA2/GNAI2/PRKAB2/RYR3/CACNA1S/CACNA2D1/CDKN1A/GNAI3/RYR1/CACNG1/ADCY7/NPR1/CACNB1/PLA2G4C/MYLK3/CAMK1D/MYLK2/ROCK2/PLA2G4F/MEF2C/ADCY9/EGFR/GUCY1A2/PRKCB/CAMK2B/CAMKK2/PPP1CA/CCND1/MAPK1/CALML6/CACNA1D/MYLK4/PRKAG2/RGS2/PPP3R1/PLCB4/FOS/CAMK2G/MYL9/CAMK2A/PRKAG3/PIK3R6/PLA2G4A	46
KEGG	hsa05203	Viral carcinogenesis	58/1614	204/8135	0.001792	0.01125	0.007448	PRKACB/NRAS/TRAF3/GRB2/HLA-A/HLA-F/HLA-C/IRF9/HLA-G/CCR5/SYK/CHEK1/BAX/TRADD/CREB3/CDC42/LYN/CDKN1A/IKBKG/VAC14/CCNE2/REL/PIK3CD/PMAIP1/HLA-E/HLA-B/SND1/CDK4/CCND2/GTF2A1/CCNA2/JAK3/SP100/HDAC1/CDC20/CDK1/TP53/GTF2E2/CREB3L2/HDAC4/NFKBIA/HDAC3/CCND3/BAK1/CCND1/MAPK1/IRF3/HPN/EGR2/EIF2AK2/KAT2B/YWHAZ/YWHAB/DDX3X/STAT5A/IRF7/ACTN1/MAD1L1	58
KEGG	hsa05214	Glioma	26/1614	75/8135	0.00182	0.01125	0.007448	DDB2/NRAS/GRB2/EGF/BAX/CDKN1A/SHC1/PIK3CD/PTEN/CDK4/E2F3/CAMK1D/EGFR/TP53/PRKCB/CAMK2B/PDGFRA/BAK1/CCND1/MAPK1/CALML6/AKT1/AKT2/CAMK2G/CAMK2A/GADD45A	26
KEGG	hsa05131	Shigellosis	68/1614	247/8135	0.001902	0.01153	0.007634	ARPC5/HCLS1/PYCARD/ACTR2/FNBP1L/RPS6KA5/MYD88/MAPK13/ITGB1/RIPK1/TECPR1/RBCK1/FOXO6/BAX/TRADD/ARPC1B/CCL5/CD44/MYL2/CDC42/HK3/CXCL8/IKBKG/PRKCD/PIK3CD/TNFRSF1A/UBE2D4/TLN2/ACTR3/ARPC2/RIPK2/MYLPF/ROCK2/PRKCQ/ITGA5/EGFR/CSF2/TLN1/ARPC3/TP53/PLCD4/RPS6KB2/ELMO1/PFN1/NFKBIA/IL18/SHARPIN/WASF2/MAPK1/ARPC4/IRF3/IL1R1/CYCS/TLR5/SQSTM1/AKT1/TLR4/CASP4/AKT2/PLCB4/CD14/BCL2/MYL9/TIFA/PLCE1/MAPK12/ELMO2/ACTN1	68
KEGG	hsa04022	cGMP-PKG signaling pathway	49/1614	167/8135	0.001934	0.01153	0.007634	PLN/ATP1A2/GNAQ/GNAI2/SLC8A3/SLC25A6/CREB3/MYH7/ATP1B4/CACNA1S/GNAI3/CNGA1/ADCY7/GNA12/NPR1/SLC25A4/MYH6/MYLK3/ATP2A1/EDNRB/MYLK2/ROCK2/MRVI1/MEF2C/ADCY9/SLC25A5/ADRA1A/GUCY1A2/CREB3L2/PPP1CA/PRKG1/ATP1A1/MAPK1/CALML6/CACNA1D/MYLK4/RGS2/PPP3R1/AKT1/AKT2/PLCB4/ATP2B1/ATP1B3/ATP1B2/VASP/MYL9/ADRA2C/ATP2B2/PIK3R6	49
KEGG	hsa04217	Necroptosis	47/1614	159/8135	0.002005	0.01175	0.007777	PYCARD/STAT1/TNFAIP3/IRF9/FADD/SLC25A6/RIPK1/RBCK1/BAX/TRADD/PYGM/TNFSF10/TNFRSF1A/TYK2/SLC25A4/FAS/PLA2G4C/MLKL/BID/CYBB/JAK3/PLA2G4F/BIRC3/SLC25A5/IFNA7/HSP90AB1/IFNAR2/CAMK2B/GLUL/IFNGR1/PPIA/RIPK3/CHMP1A/FTL/SHARPIN/IFNAR1/IL33/STAT6/SQSTM1/EIF2AK2/TLR4/BCL2/CAMK2G/CAMK2A/FTH1/STAT5A/PLA2G4A	47
KEGG	hsa04922	Glucagon signaling pathway	34/1614	107/8135	0.00221	0.01273	0.008423	PRKACB/GNAQ/PRKAA2/PPP4C/PRKAB2/PCK2/PHKA1/CREB3/PYGM/ACACB/PPARGC1A/PFKL/SIK1/FBP2/PGAM1/PGAM2/PFKM/CREB3L2/CAMK2B/LDHAL6A/CALML6/FBP1/PRKAG2/SIK2/PPP3R1/ACACA/SLC2A1/AKT1/G6PC2/AKT2/PLCB4/CAMK2G/CAMK2A/PRKAG3	34
KEGG	hsa04218	Cellular senescence	46/1614	156/8135	0.002349	0.0133	0.008799	NRAS/HLA-A/MAPK13/SMAD3/RASSF5/HLA-F/HLA-C/HLA-G/SLC25A6/CHEK1/CXCL8/CDKN1A/CCNE2/PIK3CD/HLA-E/PTEN/SLC25A4/ETS1/HLA-B/FOXM1/LIN54/CDK4/CCND2/MCU/E2F3/CCNB1/EIF4EBP1/CCNA2/SLC25A5/CDK1/TP53/CCND3/PPP1CA/ZFP36L2/CCND1/MAPK1/CALML6/CACNA1D/PPP3R1/SQSTM1/AKT1/AKT2/MAPK12/CCNB2/HIPK3/GADD45A	46
KEGG	hsa05222	Small cell lung cancer	30/1614	92/8135	0.002525	0.01404	0.00929	DDB2/COL4A5/CKS2/TRAF3/ITGB1/RXRG/BAX/COL4A6/CDKN1A/IKBKG/CCNE2/PIK3CD/PTEN/CDK4/TRAF4/E2F3/BIRC3/TP53/LAMA2/CASP9/NFKBIA/BAK1/CCND1/CYCS/AKT1/LAMA3/AKT2/COL4A4/BCL2/GADD45A	30
KEGG	hsa05414	Dilated cardiomyopathy	31/1614	96/8135	0.002564	0.01404	0.00929	PRKACB/PLN/SGCG/ITGB1/DES/TNNC1/TPM4/SLC8A3/TTN/MYH7/MYL2/TPM2/TPM3/CACNA1S/CACNA2D1/CACNG1/ADCY7/MYH6/ACTC1/CACNB1/TPM1/MYL3/ATP2A1/ITGA5/SGCA/ADCY9/DMD/ITGA7/ITGA1/LAMA2/CACNA1D	31
KEGG	hsa01524	Platinum drug resistance	25/1614	73/8135	0.00267	0.0143	0.009467	FADD/BAX/CDKN1A/PIK3CD/PMAIP1/ATP7A/FAS/BID/TOP2A/BIRC3/TP53/POLH/MGST3/GSTM1/CASP9/BAK1/MAPK1/GSTM2/GSTO1/GSTP1/CYCS/AKT1/ERCC1/AKT2/BCL2	25
KEGG	hsa05160	Hepatitis C	46/1614	157/8135	0.002698	0.0143	0.009467	NRAS/STAT1/TRAF3/GRB2/EGF/IRF9/FADD/RIPK1/BAX/TRADD/CDKN1A/CXCL10/IKBKG/PIK3CD/TNFRSF1A/TYK2/FAS/CDK4/BID/E2F3/RNASEL/IFNA7/CD81/EGFR/MX2/TP53/IFNAR2/CASP9/DDX58/CLDN6/NFKBIA/BAK1/IFNAR1/CLDN8/CCND1/MAPK1/IRF3/CYCS/AKT1/EIF2AK2/CLDN17/AKT2/YWHAZ/YWHAB/CLDN23/IRF7	46
KEGG	hsa04514	Cell adhesion molecules	44/1614	149/8135	0.0028	0.01461	0.009671	ALCAM/ITGB2/HLA-A/HLA-F/CNTN1/ITGB1/HLA-C/HLA-G/CD34/SDC1/GLG1/LRRC4C/HLA-DPB1/NRXN3/ICAM3/SELL/HLA-E/SELPLG/HLA-DMB/HLA-B/CD86/NRXN1/HLA-DMA/HLA-DRB4/PTPRC/NEGR1/CD80/IGSF11/CLDN6/CD99/CD40/CLDN8/SDC3/SELE/HLA-DPA1/ITGAM/CD2/NCAM1/CDH15/CLDN17/HLA-DRA/CLDN23/SIGLEC1/NLGN1	44
KEGG	hsa04919	Thyroid hormone signaling pathway	37/1614	121/8135	0.003065	0.01575	0.01042	PRKACB/NRAS/PLN/ATP1A2/STAT1/RXRG/MYH7/ATP1B4/RCAN2/PFKL/THRB/PIK3CD/NCOA1/MYH6/ATP2A1/HDAC1/PFKM/MED17/TP53/PRKCB/PLCD4/CASP9/MED14/HDAC3/TBC1D4/HIF1A/CCND1/ATP1A1/MAPK1/SLC2A1/AKT1/KAT2B/AKT2/PLCB4/ATP1B3/ATP1B2/PLCE1	37
KEGG	hsa05230	Central carbon metabolism in cancer	24/1614	70/8135	0.003165	0.01602	0.0106	NRAS/SCO2/GLS/HK3/PFKL/G6PD/PIK3CD/PTEN/PGAM1/PGAM2/PFKM/EGFR/TP53/PDGFRA/PDK1/LDHAL6A/HIF1A/MAPK1/SLC2A1/AKT1/AKT2/NTRK3/SLC7A5/SLC1A5	24
KEGG	hsa00010	Glycolysis / Gluconeogenesis	23/1614	67/8135	0.003753	0.01871	0.01238	GALM/PGM2/PCK2/AKR1A1/HK3/PFKL/ENO3/ACSS2/FBP2/ADPGK/PGAM1/PGAM2/ENO2/ADH1C/ADH1B/PFKM/ALDH1B1/ENO1/LDHAL6A/FBP1/ALDH3A2/MINPP1/G6PC2	23
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	39/1614	131/8135	0.004047	0.01988	0.01316	NRAS/ITGB2/RAC2/MICB/GRB2/HLA-A/HLA-C/TYROBP/HLA-G/HCST/VAV3/MICA/SYK/TNFSF10/FCER1G/SHC1/PIK3CD/HLA-E/HLA-B/FCGR3B/FAS/BID/IFNA7/RAET1E/CSF2/IFNAR2/PRKCB/NCR2/LCP2/VAV1/IFNGR1/PTPN6/IFNAR1/MAPK1/CD48/PPP3R1/ULBP1/LAT/KIR3DL1	39
KEGG	hsa04530	Tight junction	48/1614	169/8135	0.004352	0.02106	0.01394	PRKACB/ARPC5/HCLS1/ACTR2/PRKAA2/ARHGEF18/ITGB1/RAB8B/PRKAB2/EZR/AMOT/ARPC1B/PRKCZ/MYL2/CDC42/MPDZ/PARD3/BVES/ACTR3/MAGI1/RAB8A/ARPC2/CDK4/PCNA/ROCK2/YBX3/ARPC3/CLDN6/NEDD4/CRB3/TJP1/CLDN8/CCND1/ARPC4/CACNA1D/MICALL2/RAB13/PRKAG2/SYNPO/EPB41L4B/CLDN17/PARD6A/VASP/MYL9/CLDN23/PRKAG3/ACTN1/MSN	48
KEGG	hsa04664	Fc epsilon RI signaling pathway	23/1614	68/8135	0.004629	0.022	0.01456	NRAS/RAC2/GRB2/MAPK13/FCER1A/VAV3/SYK/LYN/FCER1G/PIK3CD/BTK/PLA2G4C/PLA2G4F/CSF2/ALOX5/LCP2/VAV1/MAPK1/AKT1/AKT2/LAT/MAPK12/PLA2G4A	23
KEGG	hsa05332	Graft-versus-host disease	16/1614	42/8135	0.004678	0.022	0.01456	HLA-A/HLA-F/HLA-C/HLA-G/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/CD86/HLA-DMA/FAS/HLA-DRB4/CD80/HLA-DPA1/HLA-DRA/KIR3DL1	16
KEGG	hsa05212	Pancreatic cancer	25/1614	76/8135	0.00489	0.02268	0.01501	DDB2/RAC2/STAT1/SMAD3/EGF/BAX/CDC42/CDKN1A/IKBKG/RALA/PIK3CD/CDK4/E2F3/ARHGEF6/EGFR/TP53/RPS6KB2/CASP9/BAK1/CCND1/MAPK1/RALGDS/AKT1/AKT2/GADD45A	25
KEGG	hsa04659	Th17 cell differentiation	33/1614	108/8135	0.005056	0.02311	0.01529	STAT1/MAPK13/SMAD3/IL21R/IL4R/RXRG/RORC/HLA-DPB1/IKBKG/NFKBIE/TYK2/HLA-DMB/HLA-DMA/JAK3/HLA-DRB4/PRKCQ/HSP90AB1/IFNGR1/NFKBIA/HIF1A/MAPK1/IL1R1/HLA-DPA1/CD3D/IL27RA/PPP3R1/STAT6/IL27/FOS/LAT/HLA-DRA/MAPK12/STAT5A	33
KEGG	hsa05150	Staphylococcus aureus infection	30/1614	96/8135	0.00512	0.02311	0.01529	C1R/ITGB2/KRT25/C2/HLA-DPB1/SELPLG/HLA-DMB/FCGR3B/HLA-DMA/C1QB/HLA-DRB4/CFB/FPR1/C1S/KRT27/KRT37/MBL2/C5AR1/FCGR1A/FCGR2A/HLA-DPA1/FPR3/ITGAM/C1QA/DEFA6/C3AR1/KRT32/DSG1/KRT31/HLA-DRA	30
KEGG	hsa04020	Calcium signaling pathway	64/1614	240/8135	0.005663	0.02522	0.01669	PRKACB/ERBB4/PLN/GNAQ/CASQ2/TNNC1/SLC8A3/EGF/SLC25A6/ASPH/TRDN/CXCR4/HRC/PHKA1/GNA15/RYR3/TNNC2/CACNA1S/RYR1/SPHK1/FGF4/P2RX4/ADCY7/LHCGR/CASQ1/SLC25A4/MYLK3/P2RX7/MCU/ATP2A1/EDNRB/CCKBR/CAMK1D/MYLK2/ADCY9/GNAL/SLC25A5/ADRA1A/EGFR/PRKCB/PLCD4/CAMK2B/ERBB3/PDGFRA/GDNF/PTGER3/CALML6/CACNA1D/MYLK4/FLT1/AVPR1A/PPP3R1/FGF20/HTR2A/PLCB4/ATP2B1/SPHK2/CAMK2G/CAMK2A/NTRK3/PLCE1/ORAI3/ATP2B2/CHRM2	64
KEGG	hsa04940	Type I diabetes mellitus	16/1614	43/8135	0.006104	0.02683	0.01775	HLA-A/HLA-F/HLA-C/HLA-G/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/CD86/HLA-DMA/FAS/HLA-DRB4/CD80/HLA-DPA1/GAD2/HLA-DRA	16
KEGG	hsa05142	Chagas disease	31/1614	102/8135	0.007031	0.03023	0.02001	MYD88/GNAQ/MAPK13/GNAI2/FADD/TLR2/GNA15/CCL5/CXCL8/GNAI3/IKBKG/PIK3CD/TNFRSF1A/IRAK1/FAS/C1QB/GNAL/IRAK4/IFNGR1/NFKBIA/MAPK1/C1QA/CD3D/AKT1/TLR4/CCL2/AKT2/PLCB4/FOS/TLR6/MAPK12	31
KEGG	hsa04144	Endocytosis	66/1614	251/8135	0.007061	0.03023	0.02001	WIPF1/ARPC5/ACTR2/AMPH/HLA-A/CAPZA1/SMAP2/SMAD3/HLA-F/HLA-C/HGS/HLA-G/CAPZB/CCR5/CXCR4/CAV3/GRK5/ARPC1B/PRKCZ/CDC42/ACAP2/SH3GL3/ZFYVE9/MVB12A/PARD3/HLA-E/WIPF3/ARF4/ARFGAP3/ACTR3/HLA-B/HSPA6/RAB8A/ARPC2/RAB5C/BIN1/VPS37B/ARF3/STAMBP/EHD3/EGFR/ARPC3/ZFYVE16/SNX12/SH3GL2/ZFYVE27/PDGFRA/CHMP1A/STAM2/NEDD4/ARPC4/LDLRAP1/ARAP1/IQSEC2/ARRB2/CLTCL1/SH3KBP1/RAB31/EPS15L1/ASAP1/PARD6A/USP8/WWP1/CBL/CLTA/AP2S1	66
KEGG	hsa04071	Sphingolipid signaling pathway	35/1614	119/8135	0.007681	0.03247	0.02149	NRAS/RAC2/GNAQ/MAPK13/GNAI2/FCER1A/BAX/TRADD/PRKCZ/CERS2/CTSD/FCER1G/GNAI3/SPHK1/PIK3CD/GNA12/TNFRSF1A/PTEN/BID/ROCK2/SMPD2/CERS6/TP53/PRKCB/SGPL1/MAPK1/AKT1/CERS5/AKT2/PLCB4/PPP2R3A/SPHK2/BCL2/MAPK12/DEGS1	35
KEGG	hsa03060	Protein export	10/1614	23/8135	0.00835	0.03429	0.02269	SPCS3/SEC61B/SEC61A1/SRPRB/SPCS2/SPCS1/SRP19/IMMP2L/HSPA5/SEC11C	10
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	10/1614	23/8135	0.00835	0.03429	0.02269	ATP1A2/SLC4A4/PCK2/GLS/ATP1B4/CA4/ATP1A1/SLC25A10/ATP1B3/ATP1B2	10
KEGG	hsa04918	Thyroid hormone synthesis	24/1614	75/8135	0.008418	0.03429	0.02269	PRKACB/ATP1A2/PDIA4/GNAQ/CREB3/ATP1B4/ASGR1/DUOX2/ADCY7/HSP90B1/ADCY9/GPX8/PRKCB/CREB3L2/ATP1A1/HSPA5/CANX/SLC5A5/CGA/GPX1/TTF2/PLCB4/ATP1B3/ATP1B2	24
KEGG	hsa00030	Pentose phosphate pathway	12/1614	30/8135	0.00878	0.0351	0.02323	PGM2/PGLS/PFKL/G6PD/FBP2/RPE/PFKM/RGN/FBP1/DERA/TKT/TKTL2	12
KEGG	hsa04152	AMPK signaling pathway	35/1614	120/8135	0.008828	0.0351	0.02323	ADIPOQ/PRKAA2/PRKAB2/PCK2/CREB3/ACACB/PPARGC1A/PFKL/CD36/PIK3CD/FBP2/RAB8A/SCD/LEP/EIF4EBP1/CCNA2/MLYCD/PFKM/ADRA1A/CREB3L2/RPS6KB2/HMGCR/FASN/CAMKK2/CCND1/FBP1/SCD5/PRKAG2/SLC2A4/ACACA/AKT1/G6PC2/AKT2/PPP2R3A/PRKAG3	35
KEGG	hsa05219	Bladder cancer	15/1614	41/8135	0.009319	0.03662	0.02423	NRAS/TYMP/RPS6KA5/MMP9/EGF/CXCL8/CDKN1A/MMP1/CDK4/E2F3/EGFR/TP53/RASSF1/CCND1/MAPK1	15
KEGG	hsa04926	Relaxin signaling pathway	37/1614	129/8135	0.009636	0.03742	0.02477	PRKACB/NRAS/COL4A5/GRB2/MAPK13/GNAI2/MMP9/MMP13/GNA15/CREB3/PRKCZ/COL4A6/GNB2/GNAI3/ADCY7/SHC1/PIK3CD/MMP1/EDNRB/EDN1/ADCY9/EGFR/CREB3L2/NFKBIA/RLN1/MAPK1/GNG11/COL1A2/ARRB2/AKT1/RXFP2/COL3A1/AKT2/PLCB4/COL4A4/FOS/MAPK12	37
KEGG	hsa04971	Gastric acid secretion	24/1614	76/8135	0.01005	0.03857	0.02553	PRKACB/ATP1A2/GNAQ/GNAI2/EZR/ATP1B4/GNAI3/ADCY7/MYLK3/KCNJ15/CCKBR/MYLK2/ADCY9/PRKCB/CAMK2B/ATP1A1/CALML6/MYLK4/PLCB4/ATP1B3/ATP1B2/CAMK2G/CAMK2A/SLC26A7	24
KEGG	hsa05320	Autoimmune thyroid disease	18/1614	53/8135	0.011	0.04175	0.02763	HLA-A/HLA-F/HLA-C/HLA-G/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/CD86/HLA-DMA/FAS/HLA-DRB4/IFNA7/CD80/CD40/HLA-DPA1/CGA/HLA-DRA	18
KEGG	hsa04722	Neurotrophin signaling pathway	34/1614	119/8135	0.0135	0.05067	0.03354	NRAS/RPS6KA5/GRB2/IRAK3/MAPK13/BAX/CDC42/RPS6KA1/PRKCD/MAP3K3/NFKBIE/BDNF/SHC1/PIK3CD/IRAK1/RIPK2/TP53/IRAK4/CAMK2B/NFKBIA/MAPK1/CALML6/SH2B3/RAP1B/AKT1/GAB1/AKT2/SH2B2/BCL2/CAMK2G/CAMK2A/NTRK3/MAPK12/IRAK2	34
KEGG	hsa05210	Colorectal cancer	26/1614	86/8135	0.0138	0.05069	0.03355	DDB2/NRAS/RAC2/GRB2/SMAD3/EGF/BAX/CDKN1A/RALA/PIK3CD/PMAIP1/EGFR/TP53/RPS6KB2/CASP9/BAK1/CCND1/MAPK1/CYCS/RALGDS/AKT1/TCF7L1/AKT2/FOS/BCL2/GADD45A	26
KEGG	hsa05213	Endometrial cancer	19/1614	58/8135	0.01381	0.05069	0.03355	DDB2/NRAS/GRB2/EGF/CTNNA3/BAX/CDKN1A/PIK3CD/PTEN/EGFR/TP53/CASP9/BAK1/CCND1/MAPK1/AKT1/TCF7L1/AKT2/GADD45A	19
KEGG	hsa04612	Antigen processing and presentation	24/1614	78/8135	0.01407	0.05073	0.03357	TAP1/HLA-A/HLA-F/HLA-C/HLA-G/CTSB/HLA-DPB1/HLA-E/HLA-DMB/HLA-B/HSPA6/CTSL/HLA-DMA/PDIA3/HLA-DRB4/HSP90AB1/PSME1/HSPA5/HLA-DPA1/TAP2/CANX/HLA-DRA/KIR3DL1/CTSS	24
KEGG	hsa04630	JAK-STAT signaling pathway	44/1614	162/8135	0.01412	0.05073	0.03357	FHL1/IL17D/STAT1/GRB2/IL21R/IL10RA/EGF/IRF9/IL4R/GHR/PIAS3/IL7R/CSF2RB/CDKN1A/PIK3CD/TYK2/LEP/OSMR/CCND2/JAK3/IFNA7/EGFR/CSF2/IFNAR2/SOCS7/IFNGR1/PDGFRA/STAM2/PTPN6/CCND3/IFNAR1/CCND1/IL10RB/IL27RA/CSF2RA/IL15/STAT6/AKT1/AKT2/SOCS1/MCL1/BCL2/LIFR/STAT5A	44
KEGG	hsa04215	Apoptosis - multiple species	12/1614	32/8135	0.01554	0.0552	0.03654	BOK/FADD/BAX/PMAIP1/TNFRSF1A/BID/BIRC3/HTRA2/CASP9/BAK1/CYCS/BCL2	12
KEGG	hsa04066	HIF-1 signaling pathway	31/1614	109/8135	0.01896	0.06626	0.04386	TIMP1/EGF/HK3/CDKN1A/PFKL/ENO3/PIK3CD/ENO2/CYBB/EIF4EBP1/EDN1/PFKM/EGFR/PRKCB/RPS6KB2/CAMK2B/ENO1/IFNGR1/PDK1/LDHAL6A/HIF1A/MAPK1/FLT1/SLC2A1/AKT1/TLR4/ANGPT1/AKT2/BCL2/CAMK2G/CAMK2A	31
KEGG	hsa04110	Cell cycle	35/1614	126/8135	0.01905	0.06626	0.04386	BUB3/SMAD3/MCM5/CHEK1/CDKN1A/CDC25B/CCNE2/ORC2/CDK4/CCND2/E2F3/PCNA/PTTG1/CCNB1/CCNA2/HDAC1/CDC20/CDK1/TP53/DBF4/TTK/MCM2/CDC7/CCND3/CCND1/MCM6/MCM3/BUB1B/ORC5/YWHAZ/CDC14B/YWHAB/CCNB2/GADD45A/MAD1L1	35
KEGG	hsa04371	Apelin signaling pathway	38/1614	139/8135	0.01938	0.06672	0.04415	PRKACB/NRAS/SPP1/GNAQ/PRKAA2/GNAI2/SMAD3/PLIN1/SLC8A3/PRKAB2/RYR3/MYL2/GNB2/PPARGC1A/GNAI3/RYR1/SPHK1/ADCY7/MYLK3/MYL3/MYLK2/MEF2C/ADCY9/RPS6KB2/HDAC4/CCND1/MAPK1/GNG11/CALML6/MYLK4/PRKAG2/AKT1/AKT2/PLCB4/SPHK2/EGR1/PRKAG3/PIK3R6	38
KEGG	hsa05215	Prostate cancer	28/1614	97/8135	0.02051	0.06989	0.04626	NRAS/GRB2/MMP9/AR/EGF/CREB3/CDKN1A/IKBKG/CCNE2/PIK3CD/PTEN/HSP90B1/MMP3/E2F3/EGFR/TP53/HSP90AB1/CREB3L2/CASP9/PDGFRA/NFKBIA/CCND1/MAPK1/GSTP1/AKT1/TCF7L1/AKT2/BCL2	28
KEGG	hsa04912	GnRH signaling pathway	27/1614	93/8135	0.02101	0.07087	0.04691	PRKACB/NRAS/GRB2/GNAQ/MAPK13/CDC42/CACNA1S/PRKCD/MAP3K3/ADCY7/PLA2G4C/PLA2G4F/ADCY9/EGFR/PRKCB/CAMK2B/MAP3K4/MAPK1/CALML6/CACNA1D/CGA/PLCB4/CAMK2G/CAMK2A/EGR1/MAPK12/PLA2G4A	27
KEGG	hsa05216	Thyroid cancer	13/1614	37/8135	0.02141	0.0715	0.04732	DDB2/NRAS/RXRG/BAX/TPM3/CDKN1A/CCDC6/TP53/BAK1/CCND1/MAPK1/TCF7L1/GADD45A	13
KEGG	hsa01232	Nucleotide metabolism	25/1614	85/8135	0.02195	0.07236	0.04789	TYMP/RRM2/ENTPD3/PNP/UPP1/IMPDH1/DCK/NT5C1A/AMPD2/CANT1/AK3/DGUOK/AMPD1/NME3/ASMTL/GDA/CMPK1/DUT/NME1/TYMS/DTYMK/GUK1/NME7/TK1/TK2	25
KEGG	hsa00531	Glycosaminoglycan degradation	8/1614	19/8135	0.0221	0.07236	0.04789	HPSE/IDUA/HYAL4/GUSB/ARSB/NAGLU/HEXB/GALNS	8
KEGG	hsa04216	Ferroptosis	14/1614	41/8135	0.02236	0.07251	0.04799	GSS/CYBB/SLC40A1/ACSL3/STEAP3/PCBP2/TP53/FTL/ATG7/SLC11A2/ACSL5/SAT2/FTH1/SAT1	14
KEGG	hsa05100	Bacterial invasion of epithelial cells	23/1614	77/8135	0.02279	0.07318	0.04843	ARPC5/HCLS1/ACTR2/ITGB1/RHOG/CTNNA3/CAV3/ARPC1B/CDC42/SHC1/PIK3CD/ACTR3/ARPC2/ITGA5/ARPC3/ELMO1/WASF2/ARPC4/CLTCL1/GAB1/CBL/CLTA/ELMO2	23
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/1614	53/8135	0.02374	0.0755	0.04997	PRKACB/ATP1A2/GNAQ/SLC8A3/ATP1B4/ADCY9/PRKCB/ATP1A1/CLTCL1/VDR/PLCB4/ATP2B1/ATP1B3/ATP1B2/CLTA/ATP2B2/AP2S1	17
KEGG	hsa04910	Insulin signaling pathway	37/1614	137/8135	0.02503	0.07888	0.05221	PRKACB/NRAS/GRB2/PRKAA2/PRKAB2/PCK2/PHKA1/PPP1R3A/PYGM/PRKCZ/HK3/ACACB/PPARGC1A/SHC1/PIK3CD/INPP5A/FBP2/SORBS1/PRKAR2B/EIF4EBP1/RPS6KB2/FASN/PPP1CA/MAPK1/CALML6/FBP1/PRKAG2/SLC2A4/ACACA/AKT1/G6PC2/AKT2/SOCS1/SH2B2/TRIP10/PRKAG3/CBL	37
KEGG	hsa04917	Prolactin signaling pathway	21/1614	70/8135	0.02741	0.08556	0.05663	NRAS/IRF1/STAT1/GRB2/MAPK13/TNFSF11/SHC1/PIK3CD/LHCGR/CCND2/SOCS7/CCND1/MAPK1/GALT/CGA/AKT1/AKT2/SOCS1/FOS/MAPK12/STAT5A	21
KEGG	hsa00240	Pyrimidine metabolism	18/1614	58/8135	0.02834	0.08624	0.05708	TYMP/RRM2/ENTPD3/CAD/UPP1/DCK/NT5C1A/CANT1/NME3/ASMTL/CMPK1/DUT/NME1/TYMS/DTYMK/NME7/TK1/TK2	18
KEGG	hsa05144	Malaria	16/1614	50/8135	0.02836	0.08624	0.05708	ITGB2/MYD88/THBS2/TLR2/SDC1/THBS3/CXCL8/CD36/LRP1/CD81/IL18/CD40/SELE/TLR4/CCL2/KLRB1	16
KEGG	hsa04931	Insulin resistance	30/1614	108/8135	0.0284	0.08624	0.05708	PRKAA2/PRKAB2/PCK2/PPP1R3A/CREB3/PYGM/PRKCZ/ACACB/RPS6KA1/PPARGC1A/PRKCD/CD36/PIK3CD/TNFRSF1A/PTEN/MLXIPL/PRKCQ/PRKCB/CREB3L2/RPS6KB2/NFKBIA/TBC1D4/PPP1CA/PRKAG2/SLC2A4/SLC2A1/AKT1/G6PC2/AKT2/PRKAG3	30
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/1614	100/8135	0.03027	0.09109	0.06028	CXCL13/IL10RA/CCR5/CXCR4/CCL5/CCL4/CCL18/TNFSF10/CXCL8/CXCL10/TNFRSF1A/TNFRSF1B/CXCL3/CCR1/CXCL9/CXCL14/CCL8/CXCL6/CSF1R/TNFRSF10D/CXCL1/IL18/CCL7/IL10RB/CCR2/CCL2/CCR7/CXCL11	28
KEGG	hsa05418	Fluid shear stress and atherosclerosis	37/1614	139/8135	0.03095	0.09231	0.06109	RAC2/PRKAA2/MAPK13/MMP9/NCF2/SDC1/CYBA/CAV3/PRKCZ/IKBKG/NCF1/PIK3CD/TNFRSF1A/HSP90B1/CTSL/EDN1/MEF2C/TP53/HSP90AB1/MIR10A/MGST3/GSTM1/BMPR1A/CALML6/SELE/GSTM2/IL1R1/GSTO1/GSTP1/SQSTM1/SUMO3/AKT1/CCL2/AKT2/FOS/BCL2/MAPK12	37
KEGG	hsa04658	Th1 and Th2 cell differentiation	26/1614	92/8135	0.03218	0.09512	0.06295	STAT1/MAPK13/IL4R/HLA-DPB1/IKBKG/NFKBIE/TYK2/HLA-DMB/HLA-DMA/JAK3/HLA-DRB4/PRKCQ/IFNGR1/RUNX3/NFKBIA/MAPK1/HLA-DPA1/CD3D/PPP3R1/STAT6/FOS/LAT/HLA-DRA/MAF/MAPK12/STAT5A	26
KEGG	hsa04623	Cytosolic DNA-sensing pathway	19/1614	63/8135	0.03302	0.09675	0.06403	PYCARD/RIPK1/AIM2/ADAR/CCL5/CCL4/CXCL10/IKBKG/IFNA7/DDX58/RIPK3/NFKBIA/IL18/IRF3/IL33/POLR3H/POLR1C/IRF7/POLR2H	19
KEGG	hsa04068	FoxO signaling pathway	35/1614	131/8135	0.03337	0.09692	0.06414	NRAS/GRB2/PRKAA2/MAPK13/SMAD3/BCL6/EGF/PRKAB2/PCK2/FOXO6/IL7R/TNFSF10/CDKN1A/PIK3CD/PTEN/CCND2/CCNB1/EGFR/HOMER1/FBXO32/CCND1/MAPK1/PRKAG2/SLC2A4/AKT1/CSNK1E/G6PC2/AKT2/RAG1/STK4/MAPK12/CCNB2/PRKAG3/GADD45A/NLK	35
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1614	24/8135	0.03429	0.09874	0.06535	HS6ST3/XYLT2/HS3ST5/B4GALT7/NDST4/NDST2/B3GAT3/B3GALT6/HS2ST1	9
KEGG	hsa05220	Chronic myeloid leukemia	22/1614	76/8135	0.03597	0.1027	0.06796	DDB2/NRAS/GRB2/SMAD3/BAX/CDKN1A/IKBKG/SHC1/PIK3CD/CDK4/E2F3/HDAC1/TP53/NFKBIA/BAK1/CCND1/MAPK1/AKT1/AKT2/CBL/STAT5A/GADD45A	22
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1614	77/8135	0.04124	0.1167	0.07726	SGCG/ITGB1/DES/SLC8A3/ACTN2/CTNNA3/CACNA1S/CACNA2D1/CACNG1/DSC2/CACNB1/ATP2A1/ITGA5/SGCA/DMD/ITGA7/ITGA1/LAMA2/ACTN3/CACNA1D/TCF7L1/GJA1	22
KEGG	hsa05321	Inflammatory bowel disease	19/1614	65/8135	0.04465	0.1253	0.08295	STAT1/SMAD3/IL21R/TLR2/IL4R/RORC/HLA-DPB1/NOD2/HLA-DMB/HLA-DMA/HLA-DRB4/IFNGR1/IL18/HLA-DPA1/STAT6/TLR5/TLR4/HLA-DRA/MAF	19
KEGG	hsa05134	Legionellosis	17/1614	57/8135	0.04665	0.1298	0.08593	ITGB2/PYCARD/MYD88/TLR2/CXCL8/HSPA6/CXCL3/EEF1A2/CASP9/CXCL1/NFKBIA/IL18/ITGAM/CYCS/TLR5/TLR4/CD14	17
KEGG	hsa00051	Fructose and mannose metabolism	11/1614	33/8135	0.04796	0.1308	0.08655	PMM2/AKR1B10/GMDS/GMPPA/HK3/PFKL/FBP2/TSTA3/PFKM/FBP1/PMM1	11
KEGG	hsa04130	SNARE interactions in vesicular transport	11/1614	33/8135	0.04796	0.1308	0.08655	GOSR2/VTI1A/BET1/YKT6/STX4/BET1L/STX1A/GOSR1/STX7/VAMP8/VAMP4	11
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	15/1614	49/8135	0.04816	0.1308	0.08655	NAGK/PMM2/GMDS/PGM2/GMPPA/HK3/NPL/TSTA3/NANS/PGM3/GNPNAT1/GALT/GNPDA1/HEXB/PMM1	15
KEGG	hsa01250	Biosynthesis of nucleotide sugars	12/1614	37/8135	0.04864	0.131	0.0867	NAGK/PMM2/GMDS/PGM2/GMPPA/HK3/TSTA3/NANS/PGM3/GNPNAT1/GALT/PMM1	12
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	20/1614	70/8135	0.05001	0.1336	0.08844	CSK/TCIRG1/MAPK13/CCL5/ATP6AP1/CDC42/LYN/CXCL8/IKBKG/CXCL3/ATP6V1A/ATP6V0B/EGFR/CXCL1/NFKBIA/TJP1/ADAM10/ATP6V1C1/ATP6V1B2/MAPK12	20
KEGG	hsa04024	cAMP signaling pathway	54/1614	221/8135	0.05197	0.1378	0.09118	NPY1R/PRKACB/VIP/PLN/ATP1A2/RAC2/GNAI2/ACOX3/VAV3/CREB3/ATP1B4/CACNA1S/FXYD1/GNAI3/CNGA1/BDNF/ADCY7/PIK3CD/LHCGR/NPR1/ATP2A1/EDN1/ROCK2/CRHR1/ADCY9/PPP1R1B/CREB3L2/CAMK2B/VAV1/CRH/PTGER3/NFKBIA/PPP1CA/RAPGEF3/ATP1A1/MAPK1/CALML6/CACNA1D/RAP1B/CGA/AKT1/PTCH1/AKT2/FOS/ATP2B1/ATP1B3/ATP1B2/CAMK2G/MYL9/CAMK2A/GLI3/PLCE1/ATP2B2/CHRM2	54
KEGG	hsa04916	Melanogenesis	27/1614	101/8135	0.05606	0.1467	0.09707	PRKACB/NRAS/GNAQ/GNAI2/FZD2/CREB3/GNAI3/ADCY7/FZD1/EDNRB/EDN1/TYRP1/ADCY9/FZD4/PRKCB/CREB3L2/CAMK2B/WNT11/MAPK1/WNT9A/CALML6/WNT8A/TCF7L1/PLCB4/CAMK2G/CAMK2A/WNT8B	27
KEGG	hsa04979	Cholesterol metabolism	15/1614	50/8135	0.05664	0.1467	0.09707	APOB/PLTP/SOAT1/NPC2/CD36/LRP1/VAPA/TSPO/LPL/ABCB11/NCEH1/OSBPL5/LDLRAP1/APOE/LIPG	15
KEGG	hsa05110	Vibrio cholerae infection	15/1614	50/8135	0.05664	0.1467	0.09707	PRKACB/TCIRG1/PDIA4/SEC61B/KDELR2/SEC61A1/ATP6AP1/KDELR1/ATP6V1A/ATP6V0B/ADCY9/TJP1/ATP6V1C1/ATP6V1B2/KDELR3	15
KEGG	hsa04520	Adherens junction	20/1614	71/8135	0.05712	0.1468	0.09713	LMO7/RAC2/SMAD3/PTPRB/CTNNA3/CDC42/PARD3/SORBS1/FER/EGFR/IQGAP1/PTPN6/TJP1/WASF2/MAPK1/SNAI2/TCF7L1/CSNK2B/NLK/ACTN1	20
KEGG	hsa05340	Primary immunodeficiency	12/1614	38/8135	0.05872	0.1481	0.09802	TAP1/IL7R/IKBKG/BTK/BLNK/JAK3/PTPRC/CD40/TAP2/CD3D/DCLRE1C/RAG1	12
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/1614	15/8135	0.05884	0.1481	0.09802	GLA/NAGA/GBGT1/FUT9/HEXB/FUT1	6
KEGG	hsa05221	Acute myeloid leukemia	19/1614	67/8135	0.05898	0.1481	0.09802	NRAS/GRB2/BCL2A1/IKBKG/PIK3CD/EIF4EBP1/CCNA2/CSF2/CSF1R/RPS6KB2/FCGR1A/CCND1/MAPK1/ITGAM/AKT1/TCF7L1/AKT2/CD14/STAT5A	19
KEGG	hsa04370	VEGF signaling pathway	17/1614	59/8135	0.06264	0.1561	0.1033	NRAS/RAC2/MAPK13/CDC42/SPHK1/PIK3CD/PLA2G4C/PLA2G4F/PRKCB/CASP9/MAPK1/PPP3R1/AKT1/AKT2/SPHK2/MAPK12/PLA2G4A	17
KEGG	hsa05218	Melanoma	20/1614	72/8135	0.06491	0.1595	0.1055	DDB2/NRAS/EGF/BAX/CDKN1A/FGF4/PIK3CD/PTEN/CDK4/E2F3/EGFR/TP53/PDGFRA/BAK1/CCND1/MAPK1/FGF20/AKT1/AKT2/GADD45A	20
KEGG	hsa05231	Choline metabolism in cancer	26/1614	98/8135	0.06494	0.1595	0.1055	NRAS/RAC2/GRB2/SLC22A3/EGF/PIK3CD/PLA2G4C/DGKK/EIF4EBP1/PLA2G4F/SLC22A1/EGFR/PRKCB/RPS6KB2/PDGFRA/HIF1A/WASF2/MAPK1/SLC44A2/DGKA/RALGDS/AKT1/AKT2/DGKQ/FOS/PLA2G4A	26
KEGG	hsa05224	Breast cancer	37/1614	147/8135	0.06585	0.1605	0.1062	DDB2/NRAS/GRB2/TNFSF11/EGF/FZD2/BAX/CDKN1A/FGF4/SHC1/PIK3CD/HEY1/PTEN/NCOA1/FZD1/CDK4/E2F3/LRP5/EGFR/FZD4/TP53/RPS6KB2/WNT11/HEYL/BAK1/CCND1/MAPK1/WNT9A/WNT8A/FGF20/AKT1/TCF7L1/AKT2/FOS/GADD45A/CSNK1A1/WNT8B	37
KEGG	hsa04974	Protein digestion and absorption	27/1614	103/8135	0.06918	0.1674	0.1108	COL4A5/ATP1A2/COL23A1/SLC8A3/COL4A6/ATP1B4/ACE2/COL6A2/SLC15A1/SLC7A7/COL5A2/COL5A1/SLC36A4/COL6A3/KCNN4/COL6A6/COL24A1/ATP1A1/COL16A1/COL1A2/COL3A1/COL4A4/ATP1B3/ATP1B2/COL11A1/COL9A1/SLC1A5	27
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/1614	27/8135	0.07026	0.1688	0.1117	FUT4/B3GNT5/B3GALT1/B4GALT4/FUT5/FUT9/B4GALT3/ABO/FUT1	9
KEGG	hsa00052	Galactose metabolism	10/1614	31/8135	0.07092	0.1692	0.112	AKR1B10/GALM/PGM2/GLA/HK3/PFKL/PFKM/GAA/GALT/G6PC2	10
KEGG	hsa04730	Long-term depression	17/1614	60/8135	0.0719	0.1703	0.1127	NRAS/GNAQ/GNAI2/LYN/GNAI3/RYR1/GNA12/PLA2G4C/CRHR1/PLA2G4F/GUCY1A2/PRKCB/CRH/PRKG1/MAPK1/PLCB4/PLA2G4A	17
KEGG	hsa04911	Insulin secretion	23/1614	86/8135	0.07326	0.1723	0.114	PRKACB/ATP1A2/GNAQ/KCNN2/CREB3/ATP1B4/CACNA1S/ADCY7/ADCY9/KCNN4/PRKCB/CREB3L2/CAMK2B/ATP1A1/CACNA1D/STX1A/PCLO/SLC2A1/PLCB4/ATP1B3/ATP1B2/CAMK2G/CAMK2A	23
KEGG	hsa04923	Regulation of lipolysis in adipocytes	16/1614	56/8135	0.07424	0.1734	0.1148	NPY1R/PRKACB/GNAI2/FABP4/PLIN1/GNAI3/ADCY7/PIK3CD/NPR1/MGLL/ADCY9/PTGER3/PRKG1/CGA/AKT1/AKT2	16
KEGG	hsa05226	Gastric cancer	37/1614	149/8135	0.07781	0.1805	0.1194	DDB2/NRAS/GRB2/SMAD3/EGF/RXRG/CTNNA3/FZD2/BAX/CDKN1A/FGF4/CCNE2/SHC1/PIK3CD/FZD1/E2F3/LRP5/EGFR/FZD4/TP53/RPS6KB2/WNT11/BAK1/CCND1/MAPK1/WNT9A/WNT8A/FGF20/AKT1/GAB1/TCF7L1/AKT2/BCL2/CDH17/GADD45A/CSNK1A1/WNT8B	37
KEGG	hsa05225	Hepatocellular carcinoma	41/1614	168/8135	0.08294	0.191	0.1264	DDB2/NRAS/GRB2/SMAD3/DPF3/FZD2/BAX/CDKN1A/SHC1/PIK3CD/PTEN/FZD1/CDK4/E2F3/LRP5/EGFR/FZD4/TP53/PRKCB/MGST3/RPS6KB2/GSTM1/SMARCA2/SMARCD2/WNT11/BAK1/CCND1/MAPK1/WNT9A/GSTM2/WNT8A/GSTO1/GSTP1/AKT1/GAB1/TCF7L1/AKT2/ACTL6A/GADD45A/CSNK1A1/WNT8B	41
KEGG	hsa04934	Cushing syndrome	38/1614	155/8135	0.08736	0.1998	0.1323	PRKACB/PDE11A/GNAQ/GNAI2/MEN1/FZD2/CREB3/CACNA1S/CDKN1A/GNAI3/ADCY7/CCNE2/FZD1/CDK4/E2F3/CRHR1/ADCY9/KCNA4/EGFR/FZD4/CREB3L2/CAMK2B/CRH/WNT11/NCEH1/CCND1/MAPK1/WNT9A/CACNA1D/WNT8A/RAP1B/TCF7L1/PLCB4/CAMK2G/USP8/CAMK2A/HSD3B2/WNT8B	38
KEGG	hsa04672	Intestinal immune network for IgA production	14/1614	49/8135	0.09104	0.2069	0.1369	TNFSF13B/CXCR4/HLA-DPB1/TNFSF13/HLA-DMB/CD86/HLA-DMA/HLA-DRB4/CD80/TNFRSF17/CD40/HLA-DPA1/IL15/HLA-DRA	14
KEGG	hsa05146	Amoebiasis	26/1614	102/8135	0.09677	0.2184	0.1445	PRKACB/COL4A5/ITGB2/GNAQ/TLR2/GNA15/COL4A6/CXCL8/PIK3CD/CXCL3/RAB5C/GNAL/CSF2/PRKCB/LAMA2/CXCL1/IL1R1/COL1A2/ITGAM/LAMA3/TLR4/COL3A1/PLCB4/COL4A4/CD14/ACTN1	26
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	11/1614	37/8135	0.09956	0.2232	0.1477	CAD/ASPA/GLS/PPAT/ALDH5A1/NAT8L/GLUL/ASL/GAD2/IL4I1/GPT2	11
KEGG	hsa04211	Longevity regulating pathway	23/1614	89/8135	0.1003	0.2234	0.1478	PRKACB/NRAS/ADIPOQ/PRKAA2/PRKAB2/BAX/CREB3/PPARGC1A/ADCY7/PIK3CD/EIF4EBP1/ADCY9/ATG101/TP53/SESN2/CREB3L2/RPS6KB2/CAMKK2/EHMT2/PRKAG2/AKT1/AKT2/PRKAG3	23
KEGG	hsa04151	PI3K-Akt signaling pathway	80/1614	354/8135	0.1046	0.2299	0.1521	ERBB4/RELN/NRAS/COL4A5/SPP1/EFNA4/GRB2/PRKAA2/THBS2/ITGB1/EGF/PIK3AP1/TLR2/IL4R/PCK2/GHR/SYK/CREB3/COL4A6/IL7R/GNB2/THBS3/CDKN1A/IKBKG/FGF4/BDNF/COL6A2/CCNE2/PIK3CD/PTEN/HSP90B1/MAGI1/CDK4/TNC/OSMR/CCND2/EIF4EBP1/JAK3/ITGA5/IFNA7/COL6A3/EGFR/ITGA7/TP53/HSP90AB1/IFNAR2/CSF1R/ITGA1/LAMA2/CREB3L2/RPS6KB2/ERBB3/CASP9/COL6A6/PDGFRA/CCND3/IFNAR1/CCND1/MAPK1/GNG11/COL1A2/TNN/FLT1/FGF20/AKT1/LAMA3/TLR4/ANGPT1/IBSP/G6PC2/AKT2/COL4A4/PPP2R3A/MCL1/YWHAZ/BCL2/YWHAB/COL9A1/PIK3R6/CHRM2	80
KEGG	hsa00770	Pantothenate and CoA biosynthesis	7/1614	21/8135	0.1046	0.2299	0.1521	AASDHPPT/GADL1/PANK1/COASY/PPCDC/ALDH1B1/ALDH3A2	7
KEGG	hsa04810	Regulation of actin cytoskeleton	51/1614	218/8135	0.1075	0.2334	0.1545	NRAS/ITGB2/ARPC5/ACTR2/RAC2/ITGB1/EGF/EZR/CXCR4/VAV3/FGD3/ARPC1B/MYL2/CDC42/FGF4/PIK3CD/GNA12/ACTR3/ARPC2/MYLPF/MYLK3/ITGAX/MYLK2/ROCK2/ITGA5/ARHGEF6/EGFR/ARPC3/ITGA7/ITGA1/IQGAP1/VAV1/CFL2/PDGFRA/SSH1/IQGAP3/PFN1/PPP1CA/WASF2/MAPK1/ARPC4/ITGAM/MYLK4/FGF20/NCKAP1L/PIP4K2B/MYL9/CHRM2/ACTN1/MSN/ARHGEF12	51
KEGG	hsa04310	Wnt signaling pathway	40/1614	167/8135	0.1076	0.2334	0.1545	PRKACB/RAC2/SMAD3/TLE3/FZD2/WIF1/CTNND2/FZD1/CCND2/LGR5/ROCK2/LRP5/FZD4/TP53/PRKCB/RUVBL1/CAMK2B/PORCN/VANGL1/WNT11/CCND3/CCND1/WNT9A/ROR1/ROR2/WNT8A/CXXC4/PPP3R1/SFRP1/CSNK1E/TCF7L1/PLCB4/TLE2/CAMK2G/CAMK2A/CSNK2B/RSPO2/CSNK1A1/NLK/WNT8B	40
KEGG	hsa04725	Cholinergic synapse	28/1614	113/8135	0.1154	0.2487	0.1646	PRKACB/NRAS/GNAQ/GNAI2/CREB3/CACNA1S/GNB2/GNAI3/KCNQ4/ADCY7/PIK3CD/ADCY9/PRKCB/CREB3L2/CAMK2B/SLC18A3/MAPK1/GNG11/CACNA1D/AKT1/AKT2/PLCB4/FOS/BCL2/CAMK2G/CAMK2A/PIK3R6/CHRM2	28
KEGG	hsa04015	Rap1 signaling pathway	49/1614	210/8135	0.1166	0.2497	0.1652	NRAS/ITGB2/RAC2/EFNA4/GNAQ/MAPK13/GNAI2/RASSF5/ITGB1/EGF/VAV3/PRKCZ/CDC42/GNAI3/RALA/FGF4/PARD3/ADCY7/PIK3CD/TLN2/MAGI1/FPR1/EVL/ADCY9/EGFR/TLN1/PRKCB/CSF1R/LCP2/VAV1/PDGFRA/PFN1/RAPGEF3/MAPK1/CALML6/ITGAM/FLT1/RALGDS/RAP1B/FGF20/AKT1/ANGPT1/PARD6A/AKT2/PLCB4/LAT/VASP/PLCE1/MAPK12	49
KEGG	hsa00920	Sulfur metabolism	4/1614	10/8135	0.1179	0.2498	0.1653	PAPSS1/PAPSS2/ETHE1/TST	4
KEGG	hsa04060	Cytokine-cytokine receptor interaction	67/1614	295/8135	0.1189	0.2498	0.1653	BMP5/IL17D/CXCL16/IL17RA/IL21R/CXCL13/TNFSF11/IL10RA/TNFSF13B/IL4R/CCR5/CXCR4/GHR/INHBC/CCL5/IL7R/CCL4/CCL18/TNFSF10/CXCL8/CSF2RB/GDF10/CXCL10/MSTN/TNFSF13/TNFRSF1A/TNFRSF1B/EDAR/CXCL3/ACVR1C/FAS/LEP/OSMR/CCR1/CXCL9/CXCL14/IFNA7/CCL8/CSF2/TNFRSF17/AMHR2/IFNAR2/CXCL6/CSF1R/IFNGR1/TNFRSF10D/CXCL1/BMPR1A/TNFSF4/BMP3/IL18/CD40/IFNAR1/CCL7/IL1R1/IL10RB/IL33/CCR2/IL27RA/CSF2RA/IL15/IL27/CCL2/CCR7/TNFSF15/CXCL11/LIFR	67
KEGG	hsa00330	Arginine and proline metabolism	14/1614	51/8135	0.1189	0.2498	0.1653	CKMT2/CKM/AGMAT/ALDH18A1/SRM/ALDH1B1/CARNS1/ALDH3A2/MAOA/SMS/P4HA3/SAT2/SAT1/MAOB	14
KEGG	hsa00562	Inositol phosphate metabolism	19/1614	73/8135	0.12	0.2504	0.1657	PIK3CD/INPP5A/PTEN/PI4K2A/PLCD4/INPP5E/MTM1/MTMR6/MTMR4/INPP5J/INPP4A/CDIPT/PLCH2/PIP4K2B/MINPP1/PLCB4/PLCE1/INPP4B/PI4KB	19
KEGG	hsa00514	Other types of O-glycan biosynthesis	13/1614	47/8135	0.1239	0.2555	0.1691	GALNT6/GALNT2/GXYLT2/COLGALT1/GALNT5/PLOD3/C1GALT1/GALNT1/GALNT8/POGLUT1/GALNT7/B4GALT3/GALNT9	13
KEGG	hsa04973	Carbohydrate digestion and absorption	13/1614	47/8135	0.1239	0.2555	0.1691	ATP1A2/ATP1B4/HK3/PIK3CD/PRKCB/ATP1A1/CACNA1D/AKT1/G6PC2/AKT2/PLCB4/ATP1B3/ATP1B2	13
KEGG	hsa05031	Amphetamine addiction	18/1614	69/8135	0.1255	0.2561	0.1695	PRKACB/CREB3/HDAC1/PPP1R1B/PRKCB/CREB3L2/CAMK2B/PPP1CA/CALML6/SLC18A1/CACNA1D/STX1A/PPP3R1/MAOA/FOS/CAMK2G/CAMK2A/MAOB	18
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1614	26/8135	0.1264	0.2561	0.1695	PIGL/DPM2/PIGV/PIGB/PIGM/GPAA1/PIGZ/GPLD1	8
KEGG	hsa00340	Histidine metabolism	7/1614	22/8135	0.1284	0.2561	0.1695	ASPA/HNMT/ALDH1B1/CARNS1/ALDH3A2/MAOA/MAOB	7
KEGG	hsa04340	Hedgehog signaling pathway	15/1614	56/8135	0.1287	0.2561	0.1695	PRKACB/CSNK1D/IQCE/HHATL/CCND2/KIF3A/CSNK1G2/CCND1/ARRB2/PTCH1/CSNK1E/BCL2/GLI3/CSNK1A1/CUL3	15
KEGG	hsa00061	Fatty acid biosynthesis	6/1614	18/8135	0.1288	0.2561	0.1695	ACACB/MECR/ACSL3/FASN/ACSL5/ACACA	6
KEGG	hsa00511	Other glycan degradation	6/1614	18/8135	0.1288	0.2561	0.1695	MAN2B1/NEU1/FUCA2/MAN2B2/MANBA/HEXB	6
KEGG	hsa00600	Sphingolipid metabolism	14/1614	52/8135	0.1345	0.2659	0.176	GLA/UGCG/NEU1/CERS2/SPHK1/SMPD2/CERS6/CERK/SGPL1/GALC/HEXB/CERS5/SPHK2/DEGS1	14
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1614	106/8135	0.1374	0.2699	0.1786	PRKACB/GNAQ/GNAI2/RUNX2/TNFSF11/RXRG/MMP13/CREB3/CDKN1A/GNAI3/ADCY7/GNA12/MEF2C/LRP5/ADCY9/EGFR/PRKCB/CREB3L2/MAPK1/ARRB2/MAFB/VDR/PLCB4/FOS/BCL2/EGR1	26
KEGG	hsa00410	beta-Alanine metabolism	9/1614	31/8135	0.1449	0.2814	0.1862	ACOX3/GADL1/MLYCD/ALDH1B1/AOC3/CARNS1/GAD2/ALDH3A2/HIBCH	9
KEGG	hsa05310	Asthma	9/1614	31/8135	0.1449	0.2814	0.1862	FCER1A/HLA-DPB1/FCER1G/HLA-DMB/HLA-DMA/HLA-DRB4/CD40/HLA-DPA1/HLA-DRA	9
KEGG	hsa03320	PPAR signaling pathway	19/1614	75/8135	0.1465	0.2829	0.1872	ADIPOQ/ACOX3/FABP4/PLIN1/PLTP/RXRG/PCK2/PLIN4/CD36/MMP1/SORBS1/SCD/FABP6/ACADL/ACSL3/LPL/SCD5/ACSL5/HMGCS2	19
KEGG	hsa01522	Endocrine resistance	24/1614	98/8135	0.1508	0.2861	0.1893	PRKACB/NRAS/GRB2/MAPK13/MMP9/BAX/CDKN1A/ADCY7/SHC1/PIK3CD/CDK4/E2F3/ADCY9/EGFR/ABCB11/TP53/RPS6KB2/CCND1/MAPK1/AKT1/AKT2/FOS/BCL2/MAPK12	24
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	24/1614	98/8135	0.1508	0.2861	0.1893	PRKACB/GNAQ/MAPK13/TRPV2/P2RY2/PRKCD/ADCY7/PIK3CD/PLA2G4C/PLA2G4F/PRKCQ/ADCY9/PRKCB/CAMK2B/CYP2J2/PPP1CA/CALML6/IL1R1/HTR2A/PLCB4/CAMK2G/CAMK2A/MAPK12/PLA2G4A	24
KEGG	hsa04925	Aldosterone synthesis and secretion	24/1614	98/8135	0.1508	0.2861	0.1893	PRKACB/ATP1A2/GNAQ/CREB3/ATP1B4/CACNA1S/ADCY7/NPR1/CAMK1D/ADCY9/PRKCB/CREB3L2/CAMK2B/ATP1A1/CALML6/CACNA1D/PLCB4/ATP2B1/ATP1B3/ATP1B2/CAMK2G/CAMK2A/HSD3B2/ATP2B2	24
KEGG	hsa00983	Drug metabolism - other enzymes	20/1614	80/8135	0.1534	0.2894	0.1915	TYMP/RRM2/UPP1/IMPDH1/CYP2A6/NAT1/NME3/GUSB/MGST3/GSTM1/CMPK1/DUT/NME1/TPMT/NME7/GSTM2/TK1/TK2/GSTO1/GSTP1	20
KEGG	hsa04012	ErbB signaling pathway	21/1614	85/8135	0.1598	0.2952	0.1954	ERBB4/NRAS/GRB2/EGF/CDKN1A/SHC1/PIK3CD/EIF4EBP1/EGFR/PRKCB/RPS6KB2/CAMK2B/ERBB3/MAPK1/AKT1/GAB1/AKT2/CAMK2G/CAMK2A/CBL/STAT5A	21
KEGG	hsa04610	Complement and coagulation cascades	21/1614	85/8135	0.1598	0.2952	0.1954	C1R/ITGB2/PLAUR/C2/C6/SERPINA1/F8/C1QB/ITGAX/CFB/CD46/C1S/MBL2/C5AR1/SERPINA5/ITGAM/C1QA/CFHR3/C3AR1/CLU/VSIG4	21
KEGG	hsa00512	Mucin type O-glycan biosynthesis	10/1614	36/8135	0.1609	0.2952	0.1954	GALNT6/GALNT2/GALNT5/C1GALT1/GCNT1/GALNT1/GALNT8/ST6GALNAC2/GALNT7/GALNT9	10
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	10/1614	36/8135	0.1609	0.2952	0.1954	PNP/SIRT7/NMNAT3/NMNAT2/NT5C1A/NADSYN1/SIRT5/NAPRT/NUDT12/SIRT2	10
KEGG	hsa03030	DNA replication	10/1614	36/8135	0.1609	0.2952	0.1954	MCM5/PCNA/RNASEH2A/LIG1/MCM2/MCM6/MCM3/RFC2/RNASEH2B/FEN1	10
KEGG	hsa00640	Propanoate metabolism	9/1614	32/8135	0.1681	0.3056	0.2022	ACOX3/ACACB/ACSS2/MLYCD/SUCLA2/LDHAL6A/ACACA/SUCLG2/HIBCH	9
KEGG	hsa04660	T cell receptor signaling pathway	25/1614	104/8135	0.1686	0.3056	0.2022	NRAS/GRB2/MAPK13/VAV3/CDC42/IKBKG/NFKBIE/PIK3CD/CDK4/PRKCQ/PTPRC/CSF2/LCP2/VAV1/RASGRP1/PTPN6/NFKBIA/MAPK1/CD3D/PPP3R1/AKT1/AKT2/FOS/LAT/MAPK12	25
KEGG	hsa05217	Basal cell carcinoma	16/1614	63/8135	0.1696	0.3056	0.2022	DDB2/FZD2/BAX/CDKN1A/FZD1/FZD4/TP53/WNT11/BAK1/WNT9A/WNT8A/PTCH1/TCF7L1/GLI3/GADD45A/WNT8B	16
KEGG	hsa05202	Transcriptional misregulation in cancer	44/1614	193/8135	0.1702	0.3056	0.2022	DDB2/NFKBIZ/TSPAN7/MMP9/BCL2A1/RUNX2/BCL6/ID2/RXRG/MEN1/BAX/CXCL8/LYL1/CDKN1A/FUT8/MLF1/REL/ETV6/CD86/KLF3/PROM1/MMP3/CCND2/CCNA2/TLX1/BMP2K/HDAC1/BIRC3/MEF2C/BCL11B/CSF2/TP53/CSF1R/CD40/BAK1/FCGR1A/ITGAM/FLT1/DEFA6/CD14/HHEX/MAF/GADD45A/SSX2B	44
KEGG	hsa04010	MAPK signaling pathway	65/1614	294/8135	0.1784	0.3187	0.2109	PRKACB/ERBB4/NRAS/RAC2/EFNA4/RPS6KA5/MYD88/GRB2/FLNC/MAPK13/EGF/MAPT/TRADD/CDC42/CACNA1S/CACNA2D1/RPS6KA1/IKBKG/CACNG1/CDC25B/FGF4/MAP3K3/BDNF/GNA12/TNFRSF1A/IRAK1/HSPA6/CACNB1/FAS/PLA2G4C/PLA2G4F/MEF2C/EGFR/TP53/PRKCB/CSF1R/IRAK4/DUSP5/ERBB3/RASGRP1/FLNA/PDGFRA/PTPN5/MAP3K4/MAP4K4/MAPK1/IL1R1/CACNA1D/ARRB2/MAP3K6/FLT1/RAP1B/PPP3R1/FGF20/AKT1/ANGPT1/AKT2/FOS/CD14/STK4/MAP4K1/MAPK12/GADD45A/NLK/PLA2G4A	65
KEGG	hsa05171	Coronavirus disease - COVID-19	52/1614	232/8135	0.1797	0.3192	0.2113	C1R/STAT1/MYD88/TRAF3/MAPK13/IRF9/RPL22L1/TLR2/C2/C6/SYK/ADAR/ACE2/CXCL8/CXCL10/IKBKG/PIK3CD/RPL3L/MMP1/TNFRSF1A/IRAK1/TYK2/TLR8/MMP3/CYBB/C1QB/CFB/RPS27L/IFNA7/EGFR/CSF2/MX2/RPS15A/C1S/MBL2/IFNAR2/PRKCB/IRAK4/DDX58/C5AR1/NFKBIA/IFNAR1/MAPK1/IRF3/FCGR2A/C1QA/C3AR1/EIF2AK2/TLR4/CCL2/FOS/MAPK12	52
KEGG	hsa04915	Estrogen signaling pathway	32/1614	138/8135	0.1862	0.3291	0.2178	PRKACB/NRAS/KRT25/GRB2/GNAQ/GNAI2/MMP9/CREB3/CTSD/GNAI3/PRKCD/ADCY7/SHC1/PIK3CD/HSP90B1/HSPA6/NCOA1/ADCY9/EGFR/KRT27/KRT37/HSP90AB1/CREB3L2/MAPK1/CALML6/AKT1/KRT32/AKT2/PLCB4/FOS/BCL2/KRT31	32
KEGG	hsa04270	Vascular smooth muscle contraction	31/1614	134/8135	0.1946	0.3422	0.2265	PRKACB/GNAQ/CACNA1S/PRKCD/ADCY7/RAMP1/GNA12/NPR1/PLA2G4C/MYLK3/EDN1/MYLK2/ROCK2/PLA2G4F/MRVI1/PRKCQ/ADCY9/ADRA1A/GUCY1A2/PRKCB/PPP1CA/PRKG1/MAPK1/CALML6/CACNA1D/MYLK4/AVPR1A/PLCB4/MYL9/PLA2G4A/ARHGEF12	31
KEGG	hsa01240	Biosynthesis of cofactors	35/1614	153/8135	0.1966	0.3422	0.2265	PDXK/PMM2/KMO/CAD/VKORC1/GPHN/GGH/NMNAT3/GMPPA/NMNAT2/AKR1A1/GCH1/KYNU/SHMT2/NADSYN1/GSS/PANK1/AK3/RDH11/NME3/GUSB/COASY/PPCDC/ALDH1B1/RGN/CMPK1/NME1/NAPRT/NME7/ALDH3A2/TPK1/MOCS2/MMAB/HSD17B6/PMM1	35
KEGG	hsa00360	Phenylalanine metabolism	5/1614	16/8135	0.1968	0.3422	0.2265	MIF/AOC3/MAOA/IL4I1/MAOB	5
KEGG	hsa04913	Ovarian steroidogenesis	13/1614	51/8135	0.1977	0.3422	0.2265	PRKACB/CYP1A1/ADCY7/LHCGR/PLA2G4C/PLA2G4F/ADCY9/ALOX5/CYP1B1/CYP2J2/CGA/HSD3B2/PLA2G4A	13
KEGG	hsa04070	Phosphatidylinositol signaling system	23/1614	97/8135	0.2	0.3425	0.2267	IP6K3/PIK3CD/INPP5A/PTEN/PI4K2A/DGKK/PPIP5K2/PRKCB/PLCD4/INPP5E/MTM1/MTMR6/MTMR4/INPP4A/CDIPT/CALML6/DGKA/PIP4K2B/PLCB4/DGKQ/PLCE1/INPP4B/PI4KB	23
KEGG	hsa04713	Circadian entrainment	23/1614	97/8135	0.2	0.3425	0.2267	PRKACB/RPS6KA5/GNAQ/GNAI2/RYR3/GNB2/GNAI3/RYR1/ADCY7/ADCY9/MTNR1B/GUCY1A2/PRKCB/CAMK2B/PRKG1/MAPK1/GNG11/CALML6/CACNA1D/PLCB4/FOS/CAMK2G/CAMK2A	23
KEGG	hsa04540	Gap junction	21/1614	88/8135	0.2043	0.3482	0.2305	PRKACB/NRAS/GRB2/GNAQ/GNAI2/EGF/CSNK1D/GNAI3/ADCY7/ADCY9/EGFR/CDK1/GUCY1A2/PRKCB/PDGFRA/TJP1/PRKG1/MAPK1/HTR2A/GJA1/PLCB4	21
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1614	79/8135	0.2085	0.3536	0.234	NRAS/GRB2/EGF/BAX/SHC1/PIK3CD/PTEN/EIF4EBP1/EGFR/PRKCB/RPS6KB2/ERBB3/PDGFRA/MAPK1/AKT1/GAB1/AKT2/BCL2/GAS6	19
KEGG	hsa04970	Salivary secretion	22/1614	93/8135	0.2099	0.3541	0.2343	PRKACB/ATP1A2/GNAQ/LYZ/RYR3/ATP1B4/ADCY7/ADCY9/ADRA1A/KCNN4/GUCY1A2/PRKCB/MUC5B/PRKG1/ATP1A1/CALML6/HTN3/PLCB4/ATP2B1/ATP1B3/ATP1B2/ATP2B2	22
KEGG	hsa04622	RIG-I-like receptor signaling pathway	17/1614	70/8135	0.2125	0.3567	0.2361	TRAF3/MAPK13/FADD/RIPK1/TRADD/CXCL8/CXCL10/IKBKG/IFNA7/DDX58/NFKBIA/IRF3/SIKE1/OTUD5/DDX3X/MAPK12/IRF7	17
KEGG	hsa00071	Fatty acid degradation	11/1614	43/8135	0.2202	0.3678	0.2434	ACOX3/ACADSB/ACADL/ACSL3/ADH1C/HADH/ADH1B/ALDH1B1/ACSL5/ALDH3A2/ECI2	11
KEGG	hsa05415	Diabetic cardiomyopathy	45/1614	203/8135	0.2235	0.3714	0.2458	PDK4/PLN/RAC2/MAPK13/MMP9/SMAD3/PDK3/SLC25A6/NCF2/CYBA/PRKCZ/CTSD/MPC1/PRKCD/CD36/NCF1/G6PD/PIK3CD/COX7A1/PTEN/SLC25A4/NDUFA4L2/CYBB/ATP2A1/SLC25A5/NDUFA5/PRKCB/CAMK2B/UQCRB/TBC1D4/PPP1CA/COL1A2/COX6A2/NDUFC1/SLC2A4/SLC2A1/AKT1/COL3A1/AKT2/PLCB4/CAMK2G/CAMK2A/COX2/MAPK12/NDUFA4	45
KEGG	hsa04640	Hematopoietic cell lineage	23/1614	99/8135	0.2307	0.3815	0.2525	CD34/IL4R/HLA-DPB1/CD44/IL7R/CD36/HLA-DMB/HLA-DMA/HLA-DRB4/ITGA5/CSF2/CSF1R/ITGA1/FCGR1A/IL1R1/HLA-DPA1/ITGAM/CD2/CD3D/CSF2RA/CD33/CD14/HLA-DRA	23
KEGG	hsa04213	Longevity regulating pathway - multiple species	15/1614	62/8135	0.2361	0.3848	0.2547	PRKACB/NRAS/PRKAA2/PRKAB2/CRYAB/ADCY7/PIK3CD/HSPA6/HDAC1/ADCY9/RPS6KB2/PRKAG2/AKT1/AKT2/PRKAG3	15
KEGG	hsa00120	Primary bile acid biosynthesis	5/1614	17/8135	0.2362	0.3848	0.2547	AMACR/CH25H/CYP39A1/CYP7B1/HSD3B7	5
KEGG	hsa00910	Nitrogen metabolism	5/1614	17/8135	0.2362	0.3848	0.2547	CA3/CA4/CA14/GLUL/CA8	5
KEGG	hsa00230	Purine metabolism	29/1614	128/8135	0.2405	0.3899	0.258	PAPSS1/PAPSS2/PDE11A/RRM2/ENTPD3/PNP/PGM2/IMPDH1/DCK/ADCY7/PPAT/NT5C1A/NUDT5/NPR1/AMPD2/CANT1/AK3/DGUOK/AMPD1/ADCY9/NME3/GDA/PFAS/GUCY1A2/NME1/GUK1/NME7/PDE7A/HDDC3	29
KEGG	hsa04720	Long-term potentiation	16/1614	67/8135	0.2435	0.3928	0.26	PRKACB/NRAS/GNAQ/RPS6KA1/PPP1R1A/PRKCB/CAMK2B/PPP1CA/RAPGEF3/MAPK1/CALML6/RAP1B/PPP3R1/PLCB4/CAMK2G/CAMK2A	16
KEGG	hsa04935	Growth hormone synthesis, secretion and action	27/1614	119/8135	0.2477	0.3978	0.2633	PRKACB/NRAS/STAT1/GRB2/GNAQ/MAPK13/GNAI2/GHR/CREB3/CACNA1S/GNAI3/ADCY7/SHC1/PIK3CD/ADCY9/PRKCB/CREB3L2/GHRHR/MAPK1/CACNA1D/AKT1/AKT2/PLCB4/SOCS1/FOS/MAPK12/STAT5A	27
KEGG	hsa00480	Glutathione metabolism	14/1614	58/8135	0.2493	0.3983	0.2636	RRM2/TXNDC12/G6PD/GSS/SRM/GPX8/MGST3/GSTM1/LANCL1/GSTM2/GSTO1/GSTP1/GPX1/SMS	14
KEGG	hsa04072	Phospholipase D signaling pathway	33/1614	148/8135	0.2534	0.403	0.2667	NRAS/GRB2/EGF/FCER1A/SYK/CXCL8/FCER1G/RALA/SPHK1/ADCY7/SHC1/PIK3CD/GNA12/PLA2G4C/DGKK/PLA2G4F/ADCY9/EGFR/PDGFRA/RAPGEF3/MAPK1/GRM6/DGKA/AVPR1A/RALGDS/AKT1/GAB1/AKT2/PLCB4/DGKQ/SPHK2/PIK3R6/PLA2G4A	33
KEGG	hsa05030	Cocaine addiction	12/1614	49/8135	0.2547	0.4031	0.2668	PRKACB/GNAI2/CREB3/GNAI3/BDNF/CDK5/PPP1R1B/CREB3L2/SLC18A1/MAOA/RGS9/MAOB	12
KEGG	hsa01200	Carbon metabolism	26/1614	115/8135	0.2592	0.4084	0.2703	ACOX3/PGLS/HK3/SHMT2/PFKL/G6PD/ENO3/ACSS2/FBP2/ADPGK/PGAM1/RPE/PGAM2/ENO2/SUCLA2/PFKM/ENO1/RGN/OGDH/FBP1/SUCLG2/TKT/GPT2/TKTL2/SDSL/HIBCH	26
KEGG	hsa04710	Circadian rhythm	8/1614	31/8135	0.2621	0.411	0.272	PRKAA2/PRKAB2/RORC/CSNK1D/BHLHE41/PRKAG2/CSNK1E/PRKAG3	8
KEGG	hsa02010	ABC transporters	11/1614	45/8135	0.2699	0.4206	0.2783	TAP1/ABCC10/ABCA5/ABCA9/ABCC9/ABCB4/ABCC11/ABCB11/TAP2/ABCC5/ABCG1	11
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	46/1614	212/8135	0.2707	0.4206	0.2783	PRKACB/NRAS/GRB2/CYP1A1/GNAI2/TNFSF11/AR/BCL6/EGF/RXRG/CREB3/PAQR7/CACNA1S/RPS6KA1/GNAI3/FGF4/ADCY7/PIK3CD/HSP90B1/KPNA5/EIF4EBP1/ADCY9/EGFR/HSP90AB1/PRKCB/MGST3/CREB3L2/RPS6KB2/GSTM1/CYP1B1/CCND3/CCND1/MAPK1/GSTM2/CACNA1D/ARRB2/NR1I3/GSTO1/VDR/PAQR5/FGF20/AKT1/AKT2/FOS/BCL2/STAT5A	46
KEGG	hsa00350	Tyrosine metabolism	9/1614	36/8135	0.2754	0.4259	0.2819	ADH1C/TYRP1/ADH1B/MIF/PNMT/AOC3/MAOA/IL4I1/MAOB	9
KEGG	hsa04929	GnRH secretion	15/1614	64/8135	0.2783	0.4283	0.2835	NRAS/SPP1/GNAQ/KCNN2/CACNA1S/PIK3CD/KCNN4/PRKCB/MAPK1/CACNA1D/ARRB2/CGA/AKT1/AKT2/PLCB4	15
KEGG	hsa04150	mTOR signaling pathway	34/1614	156/8135	0.2977	0.4548	0.301	NRAS/GRB2/PRKAA2/FZD2/SLC38A9/RPS6KA1/PIK3CD/TNFRSF1A/PTEN/GRB10/ATP6V1A/FZD1/EIF4EBP1/LRP5/FZD4/PRKCB/TTI1/SESN2/RPS6KB2/WNT11/MAPK1/WNT9A/PRR5/FNIP1/WNT8A/ATP6V1C1/ATP6V1B2/AKT1/DEPTOR/AKT2/CLIP1/SLC7A5/LPIN2/WNT8B	34
KEGG	hsa00515	Mannose type O-glycan biosynthesis	6/1614	23/8135	0.2982	0.4548	0.301	FUT4/B3GAT1/POMK/FUT9/B3GALNT2/B4GALT3	6
KEGG	hsa04728	Dopaminergic synapse	29/1614	132/8135	0.3001	0.4556	0.3015	PRKACB/GNAQ/MAPK13/GNAI2/CREB3/GNB2/GNAI3/GNAL/PPP1R1B/PRKCB/CREB3L2/CAMK2B/PPP1CA/GNG11/CALML6/SLC18A1/CACNA1D/ARRB2/SCN1A/MAOA/AKT1/AKT2/PLCB4/FOS/PPP2R3A/CAMK2G/CAMK2A/MAPK12/MAOB	29
KEGG	hsa04976	Bile secretion	20/1614	89/8135	0.3043	0.4568	0.3023	PRKACB/ATP1A2/SLC4A4/KCNN2/ATP1B4/ADCY7/SLC22A7/ABCB4/NR1H4/AQP4/AQP9/ADCY9/SLC22A1/ABCB11/HMGCR/NCEH1/ATP1A1/SLC2A1/ATP1B3/ATP1B2	20
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	9/1614	37/8135	0.305	0.4568	0.3023	ATP1A2/NR3C2/ATP1B4/PIK3CD/PRKCB/ATP1A1/MAPK1/ATP1B3/ATP1B2	9
KEGG	hsa05143	African trypanosomiasis	9/1614	37/8135	0.305	0.4568	0.3023	MYD88/GNAQ/FAS/PRKCB/APOL1/IL18/SELE/PLCB4/HPR	9
KEGG	hsa01230	Biosynthesis of amino acids	17/1614	75/8135	0.3109	0.4636	0.3068	SHMT2/PFKL/ENO3/ALDH18A1/PGAM1/RPE/PGAM2/ENO2/PFKM/ENO1/GLUL/ASL/NAGS/TKT/GPT2/TKTL2/SDSL	17
KEGG	hsa00380	Tryptophan metabolism	10/1614	42/8135	0.3146	0.4669	0.309	KMO/CYP1A1/KYNU/HADH/ALDH1B1/CYP1B1/ALDH3A2/MAOA/IL4I1/MAOB	10
KEGG	hsa00561	Glycerolipid metabolism	14/1614	61/8135	0.3172	0.4688	0.3103	AKR1B10/GLA/AKR1A1/DGKK/MGLL/LPL/MBOAT1/DGAT2/ALDH1B1/DGKA/ALDH3A2/DGKQ/LPIN2/LIPG	14
KEGG	hsa04360	Axon guidance	39/1614	182/8135	0.3214	0.4727	0.3128	UNC5B/NRAS/RAC2/EFNA4/GNAI2/PLXNB2/ITGB1/RGMA/ROBO2/CXCR4/LRRC4C/PRKCZ/CDC42/FES/GNAI3/PARD3/PIK3CD/SEMA4B/ROCK2/CDK5/EFNB2/CAMK2B/EPHA5/CFL2/SEMA6D/SSH1/MAPK1/ABLIM1/PLXNC1/SEMA3G/PPP3R1/PTCH1/PLXNB1/PARD6A/CAMK2G/MYL9/CAMK2A/NGEF/ARHGEF12	39
KEGG	hsa00620	Pyruvate metabolism	11/1614	47/8135	0.3227	0.4727	0.3128	PCK2/AKR1A1/ACACB/ACSS2/ADH1C/ADH1B/LDHD/ALDH1B1/LDHAL6A/ALDH3A2/ACACA	11
KEGG	hsa04726	Serotonergic synapse	25/1614	115/8135	0.3388	0.4942	0.3271	PRKACB/NRAS/GNAQ/GNAI2/KCNN2/KCND2/CACNA1S/GNB2/GNAI3/PLA2G4C/PLA2G4F/PRKCB/ALOX5/CYP2J2/RAPGEF3/MAPK1/GNG11/SLC18A1/CACNA1D/HTR2A/MAOA/PLCB4/CYP4X1/PLA2G4A/MAOB	25
KEGG	hsa03250	Viral life cycle - HIV-1	14/1614	63/8135	0.3649	0.5288	0.35	APOBEC3B/HGS/CCR5/CXCR4/ELL2/BICD2/SAMHD1/MX2/SUPT5H/NELFB/PPIA/KAT2B/TRIM5/MAP1S	14
KEGG	hsa04140	Autophagy - animal	30/1614	141/8135	0.3657	0.5288	0.35	PRKACB/NRAS/PRKAA2/CTSB/CTSD/PRKCD/PIK3CD/PTEN/CTSL/RAB8A/LAMP2/TP53INP2/PRKCQ/LAMP1/ATG101/RPS6KB2/CAMKK2/HIF1A/MTMR4/MAPK1/ATG4C/ATG7/SQSTM1/AKT1/DEPTOR/AKT2/VAMP8/BCL2/ATG4D/VMP1	30
KEGG	hsa04914	Progesterone-mediated oocyte maturation	22/1614	102/8135	0.3679	0.5297	0.3505	PRKACB/MAPK13/GNAI2/STK10/RPS6KA1/GNAI3/CDC25B/ADCY7/PIK3CD/CCNB1/CCNA2/ADCY9/CDK1/HSP90AB1/MAPK1/AKT1/AKT2/MAPK12/CCNB2/CPEB3/CPEB1/MAD1L1	22
KEGG	hsa00260	Glycine, serine and threonine metabolism	9/1614	40/8135	0.3968	0.5688	0.3765	SHMT2/PGAM1/PGAM2/CHDH/AOC3/MAOA/SDSL/MAOB/DMGDH	9
KEGG	hsa04625	C-type lectin receptor signaling pathway	22/1614	104/8135	0.4062	0.5798	0.3837	NRAS/PYCARD/IRF1/IL17D/STAT1/MAPK13/IRF9/SYK/FCER1G/IKBKG/PRKCD/PIK3CD/NFKBIA/MAPK1/CALML6/EGR2/PPP3R1/AKT1/CLEC4M/AKT2/MAPK12/ARHGEF12	22
KEGG	hsa00220	Arginine biosynthesis	5/1614	22/8135	0.4496	0.639	0.4229	GLS/GLUL/ASL/NAGS/GPT2	5
KEGG	hsa01212	Fatty acid metabolism	12/1614	57/8135	0.4614	0.653	0.4322	ACOX3/ACADSB/SCD/MECR/ACADL/ACSL3/HADH/FASN/SCD5/ACSL5/ACACA/PPT1	12
KEGG	hsa04390	Hippo signaling pathway	32/1614	157/8135	0.464	0.6539	0.4328	BMP5/ITGB2/MOB1A/SMAD3/ID2/CTNNA3/AMOT/CSNK1D/FZD2/PRKCZ/SMAD7/PARD3/FZD1/CCND2/BIRC3/FZD4/WNT11/BMPR1A/CCND3/RASSF1/PPP1CA/CCND1/WNT9A/SNAI2/WNT8A/TEAD3/CSNK1E/PARD6A/TCF7L1/YWHAZ/YWHAB/WNT8B	32
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/1614	143/8135	0.4809	0.6749	0.4467	NRAS/GRB2/MAPK13/SMAD3/ID2/HOXA1/FZD2/INHBC/MYF5/PIK3CD/ACVR1C/FZD1/TBX3/JAK3/HAND1/FZD4/WNT11/BMPR1A/MAPK1/WNT9A/WNT8A/AKT1/AKT2/SMARCAD1/MAPK12/LIFR/NANOG/WNT8B/SMAD9	29
KEGG	hsa00280	Valine, leucine and isoleucine degradation	10/1614	48/8135	0.4888	0.683	0.4521	ACADSB/HADH/HMGCLL1/HIBADH/ALDH1B1/ALDH3A2/HMGCS2/IL4I1/MCCC2/HIBCH	10
KEGG	hsa00650	Butanoate metabolism	6/1614	28/8135	0.491	0.6834	0.4523	HADH/HMGCLL1/ALDH5A1/GAD2/HMGCS2/L2HGDH	6
KEGG	hsa04724	Glutamatergic synapse	23/1614	114/8135	0.5018	0.6955	0.4603	PRKACB/GNAQ/GNAI2/GLS/GNB2/GNAI3/ADCY7/PLA2G4C/SLC17A6/PLA2G4F/ADCY9/PRKCB/HOMER1/GLUL/SHANK2/MAPK1/GNG11/CACNA1D/GRM6/PPP3R1/PLCB4/GRIK1/PLA2G4A	23
KEGG	hsa03018	RNA degradation	16/1614	79/8135	0.5084	0.7017	0.4644	PFKL/ENO3/SKIV2L/ENO2/BTG1/DIS3L/PFKM/TOB1/PARN/ENO1/BTG3/PABPC1L/DCP1B/EDC3/DCP2/EDC4	16
KEGG	hsa04924	Renin secretion	14/1614	69/8135	0.5109	0.7022	0.4647	PRKACB/GNAQ/GNAI2/CTSB/CACNA1S/GNAI3/NPR1/EDN1/GUCY1A2/CLCA4/CALML6/CACNA1D/PPP3R1/PLCB4	14
KEGG	hsa04962	Vasopressin-regulated water reabsorption	9/1614	44/8135	0.5194	0.711	0.4706	PRKACB/CREB3/RAB5C/AQP4/DYNLL1/ADCY9/CREB3L2/STX4/NSF	9
KEGG	hsa04977	Vitamin digestion and absorption	5/1614	24/8135	0.5324	0.7259	0.4804	APOB/TCN2/SLC19A2/RBP2/SLC23A1	5
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1614	14/8135	0.5461	0.7414	0.4907	FUT8/B4GALT4/B4GALT3	3
KEGG	hsa04930	Type II diabetes mellitus	9/1614	46/8135	0.5777	0.7812	0.517	ADIPOQ/PRKCZ/HK3/PRKCD/PIK3CD/MAPK1/CACNA1D/SLC2A4/SOCS1	9
KEGG	hsa00100	Steroid biosynthesis	4/1614	20/8135	0.5818	0.7835	0.5185	SOAT1/SQLE/EBP/MSMO1	4
KEGG	hsa00564	Glycerophospholipid metabolism	19/1614	98/8135	0.5856	0.7856	0.5199	PTDSS1/PLD3/GPD1/GPD1L/PLA2G4C/DGKK/PNPLA6/PLA2G4F/MBOAT1/ETNK1/CDIPT/DGKA/LPCAT1/LYPLA2/PLA2G15/DGKQ/ETNPPL/LPIN2/PLA2G4A	19
KEGG	hsa00500	Starch and sucrose metabolism	7/1614	36/8135	0.5904	0.7887	0.522	PGM2/GYG2/PYGM/HK3/AGL/GAA/G6PC2	7
KEGG	hsa04721	Synaptic vesicle cycle	15/1614	78/8135	0.5993	0.7975	0.5278	TCIRG1/RIMS1/SYT1/ATP6V1A/SLC17A6/ATP6V0B/SLC18A3/SLC18A1/ATP6V1C1/CLTCL1/ATP6V1B2/STX1A/NSF/CLTA/AP2S1	15
KEGG	hsa00790	Folate biosynthesis	5/1614	26/8135	0.6092	0.8063	0.5337	AKR1B10/GPHN/GGH/GCH1/MOCS2	5
KEGG	hsa04727	GABAergic synapse	17/1614	89/8135	0.6122	0.8063	0.5337	PRKACB/GNAI2/GPHN/GLS/GABRA2/CACNA1S/GNB2/GNAI3/ADCY7/ADCY9/PLCL1/PRKCB/GLUL/GNG11/CACNA1D/GAD2/NSF	17
KEGG	hsa00310	Lysine degradation	12/1614	63/8135	0.6132	0.8063	0.5337	COLGALT1/EZH2/SMYD1/PLOD3/HADH/PLOD2/ALDH1B1/PRDM16/PLOD1/SETDB2/EHMT2/ALDH3A2	12
KEGG	hsa04114	Oocyte meiosis	25/1614	131/8135	0.6216	0.8142	0.5388	PRKACB/MAPK13/AR/RPS6KA1/ADCY7/CCNE2/PTTG1/CCNB1/CDC20/ADCY9/CDK1/CAMK2B/PPP1CA/MAPK1/CALML6/PPP3R1/YWHAZ/YWHAB/CAMK2G/CAMK2A/MAPK12/CCNB2/CPEB3/CPEB1/MAD1L1	25
KEGG	hsa05211	Renal cell carcinoma	13/1614	69/8135	0.6307	0.8228	0.5446	NRAS/GRB2/CDC42/CDKN1A/PIK3CD/ETS1/HIF1A/MAPK1/RAP1B/SLC2A1/AKT1/GAB1/AKT2	13
KEGG	hsa04330	Notch signaling pathway	11/1614	59/8135	0.643	0.8345	0.5523	TLE3/DTX3L/HEY1/ATXN1L/HDAC1/HEYL/PSENEN/KAT2B/TLE2/APH1B/DTX4	11
KEGG	hsa04966	Collecting duct acid secretion	5/1614	27/8135	0.6446	0.8345	0.5523	TCIRG1/ATP6V1A/ATP6V1C1/ATP6V1B2/CLCNKB	5
KEGG	hsa04613	Neutrophil extracellular trap formation	36/1614	190/8135	0.6515	0.8401	0.556	ITGB2/RAC2/MAPK13/SIGLEC9/SLC25A6/NCF2/TLR2/CYBA/SYK/NCF1/PIK3CD/SELPLG/SLC25A4/FCGR3B/TLR8/CYBB/AQP9/HDAC1/FPR1/SLC25A5/PRKCB/HDAC4/C5AR1/HDAC3/FCGR1A/MAPK1/FCGR2A/FPR3/ITGAM/ATG7/AKT1/TLR4/CASP4/AKT2/PLCB4/MAPK12	36
KEGG	hsa04927	Cortisol synthesis and secretion	12/1614	65/8135	0.659	0.8454	0.5595	PRKACB/GNAQ/CREB3/CACNA1S/ADCY7/ADCY9/KCNA4/CREB3L2/NCEH1/CACNA1D/PLCB4/HSD3B2	12
KEGG	hsa00900	Terpenoid backbone biosynthesis	4/1614	22/8135	0.6615	0.8454	0.5595	IDI2/HMGCR/HMGCS2/NUS1	4
KEGG	hsa03410	Base excision repair	6/1614	33/8135	0.6631	0.8454	0.5595	TDG/APEX2/PCNA/PARP4/LIG1/FEN1	6
KEGG	hsa04932	Non-alcoholic fatty liver disease	29/1614	155/8135	0.6708	0.8519	0.5638	ADIPOQ/PRKAA2/MAPK13/PRKAB2/BAX/CDC42/CXCL8/PIK3CD/COX7A1/TNFRSF1A/FAS/MLXIPL/NDUFA4L2/BID/LEP/NDUFA5/UQCRB/COX6A2/PRKAG2/NDUFC1/CYCS/XBP1/AKT1/AKT2/FOS/COX2/MAPK12/NDUFA4/PRKAG3	29
KEGG	hsa04146	Peroxisome	15/1614	82/8135	0.6811	0.8617	0.5703	PHYH/ACOX3/MPV17/AMACR/ACSL3/MLYCD/FAR2/HMGCLL1/MPV17L/NUDT7/NUDT12/PECR/ACSL5/PEX5/ECI2	15
KEGG	hsa03022	Basal transcription factors	8/1614	45/8135	0.6939	0.8746	0.5788	GTF2F1/GTF2H5/TAF11/TAF5/GTF2A1/GTF2E2/MNAT1/TAF2	8
KEGG	hsa04350	TGF-beta signaling pathway	17/1614	94/8135	0.7058	0.8839	0.585	BMP5/SMAD3/RGMA/ID2/INHBC/ZFYVE9/SMAD7/ACVR1C/PITX2/NBL1/AMHR2/ZFYVE16/RPS6KB2/BMPR1A/LTBP1/MAPK1/SMAD9	17
KEGG	hsa00270	Cysteine and methionine metabolism	9/1614	51/8135	0.7071	0.8839	0.585	DNMT1/TST/GSS/SRM/LDHAL6A/SMS/IL4I1/SDSL/ADI1	9
KEGG	hsa04392	Hippo signaling pathway - multiple species	5/1614	29/8135	0.7093	0.8839	0.585	MOB1A/RASSF2/RASSF1/TEAD3/CSNK1E	5
KEGG	hsa00053	Ascorbate and aldarate metabolism	5/1614	30/8135	0.7383	0.9133	0.6045	AKR1A1/GUSB/ALDH1B1/RGN/ALDH3A2	5
KEGG	hsa01523	Antifolate resistance	5/1614	30/8135	0.7383	0.9133	0.6045	GGH/SHMT2/IKBKG/TYMS/ABCC5	5
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/1614	25/8135	0.7604	0.936	0.6195	ACOX3/PLA2G4C/PLA2G4F/PLA2G4A	4
KEGG	hsa03450	Non-homologous end-joining	2/1614	13/8135	0.7623	0.936	0.6195	DCLRE1C/FEN1	2
KEGG	hsa03460	Fanconi anemia pathway	9/1614	54/8135	0.7712	0.9426	0.6238	BLM/RMI2/FANCG/FANCF/POLH/EME1/RMI1/ERCC1/PALB2	9
KEGG	hsa04014	Ras signaling pathway	42/1614	232/8135	0.7733	0.9426	0.6238	PRKACB/NRAS/RAC2/EFNA4/GRB2/RASSF5/EGF/CDC42/GNB2/IKBKG/RALA/FGF4/BDNF/REL/SHC1/PIK3CD/ETS1/PLA2G4C/RAB5C/PLA2G4F/EGFR/PRKCB/CSF1R/RASGRP1/PDGFRA/BRAP/RASSF1/MAPK1/GNG11/CALML6/FLT1/RALGDS/RAP1B/FGF20/AKT1/ANGPT1/GAB1/AKT2/LAT/STK4/PLCE1/PLA2G4A	42
KEGG	hsa00670	One carbon pool by folate	3/1614	20/8135	0.7893	0.9586	0.6345	ALDH1L1/SHMT2/TYMS	3
KEGG	hsa00062	Fatty acid elongation	4/1614	27/8135	0.8128	0.9801	0.6486	ACOT7/MECR/HADH/PPT1	4
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	4/1614	27/8135	0.8128	0.9801	0.6486	ACOX3/ACOT7/SCD/SCD5	4
KEGG	hsa04972	Pancreatic secretion	17/1614	102/8135	0.8241	0.9901	0.6553	ATP1A2/GNAQ/SLC4A4/ATP1B4/ADCY7/RAB8A/ATP2A1/ADCY9/PRKCB/CLCA4/ATP1A1/RAP1B/PLCB4/ATP2B1/ATP1B3/ATP1B2/ATP2B2	17
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1614	15/8135	0.8294	0.9929	0.6571	B3GALT4/HEXB	2
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/1614	223/8135	0.8359	0.9971	0.6599	NRAS/GRB2/CYP1A1/MAPK13/EGF/SLC25A6/NCF2/AKR1A1/CYBA/IKBKG/PRKCD/NCF1/PIK3CD/COX7A1/PTEN/SLC25A4/NDUFA4L2/SLC25A5/NDUFA5/NOX4/EGFR/MGST3/GSTM1/UQCRB/CYP1B1/NFKBIA/HIF1A/MAPK1/GSTM2/COX6A2/GSTO1/NDUFC1/AKT1/AKT2/FOS/COX2/MAPK12/NDUFA4/SLC26A2	39
KEGG	hsa05017	Spinocerebellar ataxia	24/1614	143/8135	0.8491	1	0.6618	RELN/GNAQ/VLDLR/SLC25A6/RYR1/PIK3CD/SLC25A4/MCU/ATP2A1/ATXN1L/SLC25A5/ATG101/FGF14/PSMB4/AFG3L2/PRKCB/MYOD1/PUM2/CYCS/XBP1/AKT1/AKT2/PLCB4/OPA1	24
KEGG	hsa03420	Nucleotide excision repair	7/1614	47/8135	0.8511	1	0.6618	DDB2/GTF2H5/PCNA/LIG1/MNAT1/RFC2/ERCC1	7
KEGG	hsa00591	Linoleic acid metabolism	4/1614	29/8135	0.8554	1	0.6618	PLA2G4C/PLA2G4F/CYP2J2/PLA2G4A	4
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/1614	16/8135	0.8561	1	0.6618	GADL1/GAD2	2
KEGG	hsa03430	Mismatch repair	3/1614	23/8135	0.8632	1	0.6618	PCNA/LIG1/RFC2	3
KEGG	hsa04614	Renin-angiotensin system	3/1614	23/8135	0.8632	1	0.6618	ATP6AP2/ACE2/CTSA	3
KEGG	hsa00020	Citrate cycle (TCA cycle)	4/1614	30/8135	0.8735	1	0.6618	PCK2/SUCLA2/OGDH/SUCLG2	4
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1614	78/8135	0.8738	1	0.6618	CYP1A1/CYP2A6/ADH1C/ADH1B/MGST3/GSTM1/CYP1B1/AKR7A3/GSTM2/HSD11B1/GSTO1/GSTP1	12
KEGG	hsa00450	Selenocompound metabolism	2/1614	17/8135	0.8789	1	0.6618	PAPSS1/PAPSS2	2
KEGG	hsa00590	Arachidonic acid metabolism	9/1614	61/8135	0.8801	1	0.6618	PTGES/PLA2G4C/PLA2G4F/GPX8/ALOX5/TBXAS1/CYP2J2/GPX1/PLA2G4A	9
KEGG	hsa04714	Thermogenesis	39/1614	232/8135	0.8976	1	0.6618	PRKACB/NRAS/GRB2/COX18/PRKAA2/MAPK13/PLIN1/PRKAB2/DPF3/CREB3/KLB/RPS6KA1/PPARGC1A/ADCY7/COX7A1/NPR1/NDUFA4L2/ACSL3/MGLL/ADCY9/NDUFA5/CREB3L2/RPS6KB2/PRDM16/SMARCA2/SMARCD2/NDUFAF4/UQCRB/PRKG1/COX6A2/PRKAG2/NDUFC1/ACSL5/ACTL6A/COX20/COX2/MAPK12/NDUFA4/PRKAG3	39
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	10/1614	69/8135	0.9021	1	0.6618	CYP1A1/CYP2A6/NAT1/MGST3/GSTM1/CYP1B1/GSTM2/HSD11B1/GSTO1/GSTP1	10
KEGG	hsa04136	Autophagy - other	4/1614	32/8135	0.9037	1	0.6618	ATG101/ATG4C/ATG7/ATG4D	4
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1614	11/8135	0.9123	1	0.6618	VKORC1	1
KEGG	hsa05168	Herpes simplex virus 1 infection	87/1614	495/8135	0.9149	1	0.6618	ZNF267/TAP1/STAT1/PILRA/MYD88/TRAF3/HLA-A/ZNF302/HLA-F/HLA-C/IRF9/HLA-G/FADD/ZNF282/TLR2/ZNF527/ZNF275/SYK/ZNF382/BAX/TRADD/CCL5/HLA-DPB1/ZFP69/ZNF544/IKBKG/PIK3CD/HLA-E/TNFRSF1A/IRAK1/TYK2/HLA-DMB/HLA-B/ZNF600/HLA-DMA/FAS/ZNF813/BID/ZNF124/RNASEL/EIF4EBP1/PDIA3/SP100/ZNF792/HLA-DRB4/ITGA5/BIRC3/ZFP14/IFNA7/ZNF347/ZNF439/TP53/IFNAR2/ZFP90/IRAK4/CASP9/DDX58/ZNF557/ZNF764/IFNGR1/ZNF25/ZNF791/NFKBIA/ZNF785/PPP1CA/BAK1/IFNAR1/IRF3/HLA-DPA1/ZNF805/TAP2/ZNF184/CYCS/ZNF700/AKT1/EIF2AK2/CCL2/AKT2/ZNF284/BCL2/HLA-DRA/ZNF101/ZNF529/ZNF430/ZNF234/IRF7/ZNF566	87
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	2/1614	19/8135	0.9149	1	0.6618	NAGS/GPT2	2
KEGG	hsa04723	Retrograde endocannabinoid signaling	23/1614	148/8135	0.9268	1	0.6618	PRKACB/GNAQ/MAPK13/GNAI2/GABRA2/CACNA1S/GNB2/GNAI3/ADCY7/RIMS1/NDUFA4L2/SLC17A6/MGLL/ADCY9/NDUFA5/PRKCB/MAPK1/GNG11/CACNA1D/NDUFC1/PLCB4/MAPK12/NDUFA4	23
KEGG	hsa00040	Pentose and glucuronate interconversions	4/1614	34/8135	0.9274	1	0.6618	AKR1B10/AKR1A1/RPE/GUSB	4
KEGG	hsa00982	Drug metabolism - cytochrome P450	10/1614	72/8135	0.9276	1	0.6618	CYP2A6/ADH1C/ADH1B/MGST3/GSTM1/GSTM2/GSTO1/GSTP1/MAOA/MAOB	10
KEGG	hsa04137	Mitophagy - animal	10/1614	72/8135	0.9276	1	0.6618	NRAS/OPTN/TP53/NBR1/HIF1A/SQSTM1/USP8/MFN2/PINK1/CSNK2B	10
KEGG	hsa05032	Morphine addiction	13/1614	91/8135	0.9339	1	0.6618	PRKACB/PDE11A/GNAI2/GABRA2/GRK5/GNB2/GNAI3/ADCY7/ADCY9/PRKCB/GNG11/ARRB2/PDE7A	13
KEGG	hsa00140	Steroid hormone biosynthesis	8/1614	61/8135	0.9374	1	0.6618	CYP1A1/SRD5A1/SRD5A3/CYP1B1/CYP7B1/HSD11B1/HSD17B6/HSD3B2	8
KEGG	hsa05010	Alzheimer disease	65/1614	384/8135	0.9394	1	0.6618	NRAS/SLC39A7/GNAQ/SLC39A11/SLC39A13/FADD/SLC25A6/MAPT/FZD2/RYR3/BACE2/CACNA1S/IKBKG/PIK3CD/COX7A1/TNFRSF1A/SLC25A4/LRP1/FAS/FZD1/NDUFA4L2/BID/CYBB/MCU/ATP2A1/CDK5/SLC39A1/LRP5/LPL/SLC25A5/NDUFA5/SLC39A4/NOX4/FZD4/ATG101/PSMB4/CASP9/UQCRB/WNT11/MAPK1/WNT9A/CALML6/ADAM10/CACNA1D/COX6A2/WNT8A/APOE/NDUFC1/CYCS/XBP1/PPP3R1/SLC11A2/AKT1/EIF2AK2/PSENEN/CSNK1E/AKT2/PLCB4/BACE1/CSNK2B/COX2/NDUFA4/APH1B/CSNK1A1/WNT8B	65
KEGG	hsa00565	Ether lipid metabolism	6/1614	49/8135	0.9429	1	0.6618	PLD3/PLA2G7/PLA2G4C/PLA2G4F/LPCAT1/PLA2G4A	6
KEGG	hsa04744	Phototransduction	3/1614	29/8135	0.9461	1	0.6618	CNGA1/CALML6/RGS9	3
KEGG	hsa05012	Parkinson disease	43/1614	266/8135	0.9487	1	0.6618	PRKACB/SLC39A7/GNAI2/SLC39A11/SLC39A13/SLC25A6/MAPT/BAX/RYR3/GNAI3/UBE2L6/COX7A1/UBE2J1/SLC25A4/NDUFA4L2/MCU/SLC39A1/GNAL/SLC25A5/NDUFA5/SLC39A4/PSMB4/TP53/CAMK2B/HTRA2/CASP9/UQCRB/CALML6/HSPA5/SLC18A1/COX6A2/NDUFC1/CYCS/XBP1/SLC11A2/MAOA/CAMK2G/CAMK2A/MFN2/PINK1/COX2/NDUFA4/MAOB	43
KEGG	hsa04120	Ubiquitin mediated proteolysis	21/1614	142/8135	0.9525	1	0.6618	DDB2/UBE2Z/PIAS3/UBE2L6/CUL5/UBE2J1/UBE2D4/RHOBTB1/BIRC3/CDC20/KLHL13/NEDD4/UBE2Q2/FBXO4/UBE2C/SOCS1/HERC4/WWP1/CBL/UBE2O/CUL3	21
KEGG	hsa05020	Prion disease	44/1614	273/8135	0.953	1	0.6618	PRKACB/RAC2/MAPK13/SLC25A6/NCF2/C6/CYBA/CAV3/BAX/RYR3/CREB3/CCL5/CACNA1S/RYR1/PRKCD/NCF1/PIK3CD/COX7A1/SLC25A4/HSPA6/NDUFA4L2/CYBB/MCU/C1QB/SLC25A5/NDUFA5/PSMB4/CREB3L2/CASP9/UQCRB/MAPK1/HSPA5/CACNA1D/C1QA/COX6A2/NCAM1/NDUFC1/CYCS/PPP3R1/EGR1/CSNK2B/COX2/MAPK12/NDUFA4	44
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1614	30/8135	0.9542	1	0.6618	SHMT2/ACSS2/GLUL	3
KEGG	hsa03013	Nucleocytoplasmic transport	15/1614	108/8135	0.9587	1	0.6618	UPF1/XPO6/TMEM33/KPNA5/EEF1A2/NXT1/EIF4A3/NUP50/XPOT/NDC1/SUMO3/IPO5/NCBP2/XPO7/XPO4	15
KEGG	hsa03015	mRNA surveillance pathway	13/1614	97/8135	0.9633	1	0.6618	UPF1/CLP1/NUDT21/RNMT/CSTF2/NXT1/CPSF1/EIF4A3/PPP1CA/PABPC1L/PPP2R3A/NCBP2/PCF11	13
KEGG	hsa00730	Thiamine metabolism	1/1614	15/8135	0.9639	1	0.6618	TPK1	1
KEGG	hsa03050	Proteasome	5/1614	46/8135	0.9653	1	0.6618	PSMB9/PSMB8/PSMB10/PSMB4/PSME1	5
KEGG	hsa05322	Systemic lupus erythematosus	19/1614	136/8135	0.9713	1	0.6618	C1R/C2/C6/HLA-DPB1/HLA-DMB/CD86/FCGR3B/HLA-DMA/C1QB/HLA-DRB4/CD80/C1S/CD40/FCGR1A/FCGR2A/HLA-DPA1/C1QA/HLA-DRA/ACTN1	19
KEGG	hsa00830	Retinol metabolism	8/1614	68/8135	0.9728	1	0.6618	CYP1A1/CYP26B1/CYP2A6/ADH1C/ADH1B/RDH11/PNPLA4/HSD17B6	8
KEGG	hsa03440	Homologous recombination	4/1614	41/8135	0.9745	1	0.6618	BLM/EME1/RAD52/PALB2	4
KEGG	hsa03020	RNA polymerase	3/1614	34/8135	0.9764	1	0.6618	POLR3H/POLR1C/POLR2H	3
KEGG	hsa04950	Maturity onset diabetes of the young	2/1614	26/8135	0.9765	1	0.6618	FOXA3/HHEX	2
KEGG	hsa05206	MicroRNAs in cancer	48/1614	310/8135	0.9813	1	0.6618	NRAS/EFNA4/RPS6KA5/GRB2/MMP9/DNMT1/EZR/EZH2/ZFPM2/GLS/CDCA5/CD44/CDKN1A/CDC25B/CCNE2/SHC1/PIK3CD/PTEN/MARCKS/TNC/CCND2/TPM1/E2F3/HDAC1/ITGA5/EGFR/FSCN1/TP53/MIR10A/PRKCB/ERBB3/HDAC4/SOX4/BMF/PDGFRA/SPRY2/CYP1B1/MDM4/RASSF1/BAK1/CCND1/MAPK1/TNN/MIR205/SOCS1/MCL1/BCL2/VIM	48
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	77/1614	476/8135	0.9848	1	0.6618	NRAS/PRPH/GNAQ/MAPK13/FADD/SLC25A6/MAPT/FZD2/BAX/RYR3/CACNA1S/SIGMAR1/RYR1/UBE2L6/BDNF/COX7A1/TNFRSF1A/UBE2J1/TNFRSF1B/SLC25A4/RAB8A/FAS/FZD1/NDUFA4L2/OPTN/BID/CYBB/MCU/ATP2A1/ATXN1L/CDK5/LRP5/SLC25A5/NDUFA5/NOX4/FZD4/ATG101/PSMB4/GPX8/PRKCB/CAMK2B/HTRA2/CASP9/NEFH/DNAH2/UQCRB/WNT11/DERL1/BAK1/MAPK1/WNT9A/CALML6/HSPA5/CACNA1D/COX6A2/HTT/WNT8A/NDUFC1/CYCS/XBP1/STX1A/PPP3R1/SQSTM1/GPX1/CSNK1E/PLCB4/BCL2/CAMK2G/CAMK2A/MFN2/PINK1/CSNK2B/COX2/MAPK12/NDUFA4/CSNK1A1/WNT8B	77
KEGG	hsa05034	Alcoholism	26/1614	187/8135	0.9871	1	0.6618	PRKACB/NRAS/GRB2/GNAI2/SLC29A3/CREB3/GNB2/GNAI3/PKIA/BDNF/SHC1/HDAC1/PPP1R1B/CREB3L2/HDAC4/CRH/HDAC3/CAMKK2/PPP1CA/MAPK1/GNG11/CALML6/SLC18A1/SLC29A2/MAOA/MAOB	26
KEGG	hsa00860	Porphyrin metabolism	3/1614	43/8135	0.9951	1	0.6618	GUSB/MMAB/HMOX2	3
KEGG	hsa04975	Fat digestion and absorption	3/1614	43/8135	0.9951	1	0.6618	APOB/CD36/DGAT2	3
KEGG	hsa00190	Oxidative phosphorylation	15/1614	134/8135	0.9975	1	0.6618	TCIRG1/ATP6AP1/COX7A1/ATP6V1A/NDUFA4L2/ATP6V0B/NDUFA5/UQCRB/COX6A2/ATP6V1C1/ATP6V1B2/NDUFC1/CYCS/COX2/NDUFA4	15
KEGG	hsa05033	Nicotine addiction	2/1614	40/8135	0.9985	1	0.6618	GABRA2/SLC17A6	2
KEGG	hsa04742	Taste transduction	5/1614	86/8135	0.9999	1	0.6618	PRKACB/GABRA2/TAS2R5/P2RY4/PLCB4	5
KEGG	hsa03040	Spliceosome	12/1614	147/8135	1	1	0.6618	PRPF6/HSPA6/HNRNPC/EIF4A3/PRPF40B/SF3B4/CCDC12/TRA2A/DDX46/HNRNPU/SRSF10/NCBP2	12
KEGG	hsa04080	Neuroactive ligand-receptor interaction	41/1614	353/8135	1	1	0.6618	NPY1R/VIP/NPY5R/GHR/GABRA2/P2RY14/P2RY2/CHRNA1/THRB/P2RX4/PARD3/LHCGR/P2RX7/LEP/TSPO/EDNRB/CCKBR/EDN1/CRHR1/FPR1/MTNR1B/ADRA1A/C5AR1/CALCR/CRH/GHRHR/PTGER3/RLN1/FPR3/GRM6/P2RY4/AVPR1A/CGA/HTR2A/C3AR1/TAAR2/RXFP2/VIPR1/GRIK1/ADRA2C/CHRM2	41
KEGG	hsa05016	Huntington disease	33/1614	306/8135	1	1	0.6618	GNAQ/SLC25A6/BAX/CREB3/PPARGC1A/BDNF/COX7A1/SLC25A4/NDUFA4L2/HDAC1/SLC25A5/NDUFA5/ATG101/PSMB4/TP53/GPX8/CREB3L2/CASP9/DNAH2/UQCRB/COX6A2/HTT/CLTCL1/NDUFC1/CYCS/STX1A/GPX1/PLCB4/COX2/NDUFA4/CLTA/AP2S1/POLR2H	33
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	6/1614	109/8135	1	1	0.6618	NXT1/POP5/EIF6/POP1/CSNK2B/UTP14A	6
KEGG	hsa05014	Amyotrophic lateral sclerosis	41/1614	364/8135	1	1	0.6618	ERBB4/PRPH/MAPK13/BAX/SIGMAR1/UBQLN4/COX7A1/TNFRSF1A/TNFRSF1B/RAB8A/NDUFA4L2/OPTN/BID/MCU/NXT1/NDUFA5/ATG101/NUP50/PSMB4/TP53/GPX8/CASP9/NEFH/NDC1/DNAH2/UQCRB/PFN1/DERL1/HSPA5/COX6A2/NDUFC1/CYCS/XBP1/PPP3R1/SQSTM1/GPX1/BCL2/PINK1/COX2/MAPK12/NDUFA4	41
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	1/1614	66/8135	1	1	0.6618	AARS2	1
KEGG	hsa03010	Ribosome	6/1614	158/8135	1	1	0.6618	RPL22L1/RPL3L/RPS27L/MRPL20/RPS15A/MRPL1	6
KEGG	hsa04740	Olfactory transduction	21/1614	440/8135	1	1	0.6618	PRKACB/SLC8A3/OR51B4/GNAL/OR1D5/CAMK2B/OR10H3/OR1F1/PRKG1/CALML6/OR8D1/ARRB2/RGS2/OR2L13/OR1I1/OR8B2/OR8D2/CAMK2G/CAMK2A/OR13C4/OR2F2	21