ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa04144	Endocytosis	167/4078	251/8135	7.133e-08	2.382e-05	1.659e-05	STAM2/SNX6/CLTB/CHMP5/AGAP4/AGAP9/ARRB2/TFRC/CAPZA2/VPS29/IL2RG/ACAP2/RNF41/CDC42/VPS25/SH3KBP1/RABEP1/RAB5C/ARPC1B/PARD3/PSD/ARPC4/SNX4/CYTH4/AP2M1/ARFGEF2/SNX2/SPG21/AP2B1/RAB7A/TGFBR2/SH3GLB2/VPS37D/RAB22A/WASL/RAB11FIP2/USP8/CHMP1A/ARPC2/ARRB1/HLA-G/SMAD2/KIF5B/AP2S1/VPS37A/CBLC/VTA1/ZFYVE16/HLA-E/CHMP6/LDLRAP1/ARF4/PRKCI/EPN1/RAB11A/CHMP1B/CCR5/HLA-B/SMAD3/ARF1/TGFBR1/CAPZA1/CLTC/RAB8A/MVB12A/GRK1/CBL/VPS37C/AGAP2/IL2RB/GRK6/SH3GLB1/HRAS/MDM2/AP2A2/SNX5/ARF5/SMURF2/ACTR3B/HSPA6/TSG101/SNX12/PIP5K1B/CAV3/EHD3/WIPF2/CHMP7/RUFY2/PARD6G/ASAP3/CYTH1/CXCR4/NEDD4/ACTR3/RAB11B/GIT2/SRC/ACAP3/CLTA/HLA-C/AMPH/CHMP2B/RAB10/SNX3/HGS/PIP5KL1/PRKCZ/PLD2/CXCR2/PDGFRA/VPS36/CYTH3/ITCH/CYTH2/HLA-A/STAMBP/PSD4/RUFY1/ARFGAP2/KIF5C/PML/SNF8/PSD2/EGFR/TRAF6/ARPC3/RAB5B/DNM3/WIPF1/EPS15/HSPA1L/RAB11FIP4/PSD3/ARF6/VPS35/EEA1/HSPA2/AP2A1/RAB11FIP5/SMURF1/STAM/PIP5K1C/EPS15L1/HLA-F/RAB35/GBF1/ARAP1/VPS4B/ARPC5L/ZFYVE9/ARFGEF1/VPS4A/SH3GL3/BIN1/AGAP3/IGF2R/EHD2/CXCR1/EHD4/PARD6A/CHMP4C/SNX32/GRK5/IQSEC3/DAB2/CBLB/GIT1	167
KEGG	hsa04218	Cellular senescence	110/4078	156/8135	1.445e-07	2.414e-05	1.681e-05	RBBP4/NFATC3/MAP2K6/PIK3CA/HIPK2/RRAS/CAPN2/MAP2K2/ZFP36L2/NFKB1/CAPN1/HIPK1/HIPK4/GADD45A/MTOR/CALML4/NRAS/TSC1/ATM/ITPR3/NFATC4/TRAF3IP2/MYC/AKT1/AKT2/TGFBR2/MCU/GADD45B/ITPR2/CCND1/TRPV4/PIK3R2/KRAS/HLA-G/SMAD2/HIPK3/TP53/NFATC1/PPP3CB/HLA-E/SLC25A4/RAD50/PPP1CB/HLA-B/MAPK14/SMAD3/PPP3R1/MAPKAPK2/TGFBR1/PIK3R1/CCND2/E2F3/PIK3CB/PPP1CA/VDAC2/CCNB2/HRAS/MDM2/IGFBP3/E2F4/ETS1/CALML5/SERPINE1/FOXO1/RASSF5/RB1/CDKN2B/SLC25A6/HLA-C/CCNA2/SIRT1/RBL2/GADD45G/CDK6/E2F5/HLA-A/RRAS2/EIF4EBP1/CDK1/CHEK2/CCNE2/CXCL8/CCNE1/NBN/FOXM1/NFATC2/LIN54/CALM1/HUS1/MRAS/MAPK13/TGFB1/MAPK1/SQSTM1/MAPK12/VDAC1/HLA-F/KIR2DL4/CDKN2A/CCNB1/LIN52/SLC25A31/AKT3/CCND3/FOXO3/CDKN1A/PPP3R2/CDK2/LIN37/MAP2K1	110
KEGG	hsa04210	Apoptosis	95/4078	136/8135	2.006e-06	0.0002234	0.0001556	DFFA/DAB2IP/PIK3CA/CASP3/CAPN2/MAP2K2/FAS/BCL2A1/CYCS/MCL1/MAPK8/NFKB1/CAPN1/CTSC/BIRC2/GADD45A/NRAS/CTSF/PIDD1/ATM/ITPR3/DDIT3/LMNB1/AKT1/TNF/PDPK1/AKT2/TUBA4A/PARP1/PMAIP1/BCL2/HTRA2/GADD45B/ITPR2/CTSD/PIK3R2/KRAS/TP53/TNFSF10/TUBA8/RIPK1/ACTB/CHUK/PIK3R1/IL3RA/PIK3CB/TNFRSF10A/BAD/HRAS/APAF1/AIFM1/BAK1/CTSL/IKBKB/TP53AIP1/CTSW/JUN/BID/LMNA/CASP9/GADD45G/PTPN13/BCL2L1/BIRC5/FOS/CTSZ/BCL2L11/PARP4/SPTAN1/CTSH/CASP12/XIAP/EIF2S1/TUBA1A/CASP6/DAXX/BIRC3/EIF2AK3/MAPK1/CTSK/DIABLO/BAX/GZMB/FASLG/LMNB2/AKT3/TRADD/CASP10/ENDOG/PARP2/ERN1/CTSS/ATF4/MAP2K1/FADD	95
KEGG	hsa00770	Pantothenate and CoA biosynthesis	20/4078	21/8135	1.079e-05	0.0006226	0.0004336	PANK2/GADL1/DPYD/CSAD/ALDH3A2/BCAT2/VNN2/PPCDC/COASY/BCAT1/PPCS/VNN1/PANK3/AASDHPPT/ENPP1/ALDH2/UPB1/ALDH1B1/PANK1/DPYS	20
KEGG	hsa04932	Non-alcoholic fatty liver disease	104/4078	155/8135	1.205e-05	0.0006226	0.0004336	UQCRQ/MLX/NDUFB3/NDUFA4/COX7A2/SDHA/PIK3CA/COX7C/COX7B/CASP3/SDHC/FAS/COX7A2L/CYCS/CDC42/NDUFS3/NDUFB2/MAPK8/NDUFA6/NFKB1/UQCRC1/UQCR11/NDUFA5/NDUFB6/UQCR10/LEP/COX5B/COX6C/DDIT3/GSK3B/NDUFS2/MLXIP/AKT1/NDUFA1/TNF/AKT2/XBP1/PRKAB1/COX1/NDUFV2/PIK3R2/NDUFA13/NDUFS4/NDUFS7/COX6A1/NR1H3/PRKAG1/ADIPOQ/MAPK14/RXRA/UQCRB/NDUFA2/PIK3R1/NDUFS1/PIK3CB/COX6A2/COX2/PRKAA2/NDUFV1/PRKAA1/IKBKB/NDUFAB1/IL6R/CEBPA/NDUFA4L2/COX7A1/JUN/BID/UQCRFS1/NDUFB5/ITCH/PRKAG2/FOS/COX5A/NDUFS6/BCL2L11/ADIPOR2/CXCL8/NDUFB4/EIF2S1/PRKAB2/MLXIPL/MAPK13/TGFB1/UQCRC2/EIF2AK3/NDUFB8/MAPK12/COX8A/BAX/COX6B1/NDUFC1/PRKAG3/FASLG/INSR/SOCS3/AKT3/COX4I2/MAP3K11/NDUFA8/SREBF1/ERN1/ATF4/INS	104
KEGG	hsa05161	Hepatitis B	108/4078	162/8135	1.281e-05	0.0006226	0.0004336	NFATC3/TBK1/PTK2B/MAP2K6/PIK3CA/CASP3/MAP2K7/MAP2K2/FAS/CYCS/MAPK8/CREB1/IRF3/NFKB1/IFIH1/JAK1/JAK2/NRAS/NFATC4/MYC/YWHAB/AKT1/TNF/AKT2/TGFBR2/ATF2/ARAF/BCL2/SOS1/PIK3R2/KRAS/TP53/NFATC1/PRKCB/CREB3L2/GRB2/DDX58/CHUK/MAPK14/SMAD3/TGFBR1/PIK3R1/E2F3/EP300/PIK3CB/JAK3/BAD/HRAS/IRF7/APAF1/TLR4/DDX3X/STAT2/IKBKB/BRAF/RB1/IFNA8/SRC/MAP2K4/CCNA2/IFNAR1/JUN/STAT1/BID/CASP9/BIRC5/STAT5A/DDB1/SOS2/TIRAP/FOS/ELK1/STAT6/CCNE2/CXCL8/CCNE1/IFNA16/NFATC2/TRAF6/IRAK1/PCNA/CASP12/MAVS/SLC10A1/MYD88/HSPG2/YWHAZ/MAPK13/TGFB1/CREB3/TLR3/MAPK1/PRKCG/MAPK12/BAX/FASLG/EGR2/AKT3/IFNB1/MAP3K7/CDKN1A/CASP10/CDK2/DDB2/ATF4/MAP2K1/FADD/TRAF3	108
KEGG	hsa05223	Non-small cell lung cancer	54/4078	72/8135	1.305e-05	0.0006226	0.0004336	PIK3CA/MAP2K2/GADD45A/ALK/NRAS/PLCG1/AKT1/PDPK1/AKT2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/KRAS/KIF5B/TP53/PRKCB/GRB2/RXRA/PIK3R1/RASSF1/E2F3/PIK3CB/JAK3/BAD/HRAS/BAK1/BRAF/RXRG/RASSF5/RB1/RXRB/CASP9/GADD45G/HGF/CDK6/STAT5A/SOS2/KIF5C/FHIT/EGFR/STK4/MAPK1/PRKCG/CDKN2A/BAX/AKT3/RARB/FOXO3/CDKN1A/DDB2/MAP2K1/EGF	54
KEGG	hsa05213	Endometrial cancer	45/4078	58/8135	1.539e-05	0.0006427	0.0004476	PIK3CA/MAP2K2/GADD45A/NRAS/GSK3B/MYC/ILK/AKT1/TCF7L2/APC2/PDPK1/AKT2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/KRAS/TP53/GRB2/PIK3R1/PIK3CB/BAD/HRAS/BAK1/BRAF/CASP9/GADD45G/SOS2/ELK1/AXIN2/EGFR/CTNNA2/MAPK1/CTNNA1/CDH1/BAX/LEF1/AKT3/FOXO3/CDKN1A/AXIN1/DDB2/MAP2K1/EGF	45
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	126/4078	194/8135	1.781e-05	0.000661	0.0004604	NFATC3/TBK1/MAP2K6/PIK3CA/PTGS2/CASP3/UBC/MAP2K7/MAP2K2/FAS/CLEC2B/CYCS/GNB4/GNG2/MAPK8/GNGT2/CREB1/IRF3/NFKB1/GNG10/GNB1/JAK1/MTOR/JAK2/CALML4/NRAS/PDGFB/ITPR3/ATG3/GSK3B/NFATC4/MYC/PLCG1/AKT1/TCF7L2/AKT2/PIK3R5/ITPR2/HCK/IRF9/CCND1/CD86/ICAM1/PIK3R2/KRAS/HLA-G/IFNGR1/RCAN1/GNB5/PIK3CG/HIF1A/TP53/NFATC1/PPP3CB/HLA-E/CCR5/CHUK/HLA-B/MAPK14/PPP3R1/MAPKAPK2/PIK3R1/GNG5/GNB2/E2F3/EP300/PIK3CB/GNB3/HRAS/IRF7/BECN1/MAP1LC3A/CALML5/BAK1/PIK3R6/STAT2/IKBKB/MAP1LC3B/UBA52/RB1/IFNA8/SRC/MAP2K4/ZFP36/HLA-C/IFNAR1/JUN/STAT1/BID/CASP9/GNG4/CDK6/HLA-A/LYN/FOS/CSF2/CD200R1/MICA/CXCL8/IFNA16/NFATC2/EIF2AK2/CALM1/MAPK13/TLR3/MAP1LC3C/MAPK1/MAPK12/IFNAR2/CXCL1/HLA-F/UBB/BAX/LEF1/RPS27A/AKT3/IFNB1/TRADD/CDKN1A/MICB/PREX1/PPP3R2/MAP2K1/GNGT1/FADD/TRAF3	126
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	64/4078	89/8135	2.182e-05	0.0006688	0.0004658	NFATC3/MAP2K6/PIK3CA/MAP2K2/CSNK2A2/NFKB1/LAT/JAK1/MTOR/ALK/CD3G/NFKBIB/JAK2/NRAS/PLCG1/PTPN6/AKT1/AKT2/CD3E/PIK3R2/KRAS/IFNGR1/HIF1A/CD28/NFATC1/PPP3CB/IFNG/CSNK2A1/PDCD1/CHUK/MAPK14/PPP3R1/PIK3R1/BATF/PIK3CB/CD4/HRAS/TLR4/BATF2/RPS6KB2/IKBKB/CD274/JUN/STAT1/CD247/TIRAP/FOS/NFATC2/EGFR/TRAF6/PRKCQ/MYD88/PTPN11/MAPK13/BATF3/LCK/MAPK1/MAPK12/CD3D/AKT3/RASGRP1/PPP3R2/MAP2K1/EGF	64
KEGG	hsa04140	Autophagy - animal	95/4078	141/8135	2.202e-05	0.0006688	0.0004658	TBK1/PPP2CA/C9orf72/PIK3CA/RRAS/VMP1/MAP2K2/IGBP1/MAPK8/ATG5/CAMKK2/MTOR/MLST8/NRAS/TSC1/RB1CC1/GABARAP/ATG3/ATG4A/EIF2AK4/AKT1/MTMR14/PDPK1/RAB7A/AKT2/BCL2/ATG4D/CTSD/PIK3R2/KRAS/RRAGC/HIF1A/PRKACB/ATG4C/MTMR3/PRKACG/SUPT20H/SMCR8/PIK3R1/RAB8A/RAB33B/PIK3CB/PRKAA2/BAD/RPTOR/SH3GLB1/HRAS/ATG12/ULK2/PRKAA1/GABARAPL2/BECN1/MAP1LC3A/HMGB1/ATG16L2/PRKACA/CTSL/RPS6KB2/MAP1LC3B/UVRAG/VAMP8/TANK/TP53INP2/BCL2L1/ATG13/RRAS2/RAB39B/AKT1S1/ATG7/SNAP29/RRAGA/DAPK1/TRAF6/DAPK3/ATG101/PRKCQ/ZFYVE1/PRKCD/EIF2S1/MRAS/RRAGB/MAP1LC3C/EIF2AK3/MAPK1/SQSTM1/WDR41/AKT3/MAP3K7/IRS4/RAB1A/ERN1/PPP2CB/GABARAPL1/MAP2K1/INS	95
KEGG	hsa05210	Colorectal cancer	62/4078	86/8135	2.572e-05	0.0007159	0.0004986	PIK3CA/CASP3/MAP2K2/CYCS/MAPK8/GADD45A/MTOR/NRAS/GSK3B/MYC/AKT1/TCF7L2/APC2/AKT2/TGFBR2/RAC2/PMAIP1/ARAF/BCL2/GADD45B/SOS1/CCND1/PIK3R2/KRAS/SMAD2/TP53/GRB2/SMAD3/TGFBR1/PIK3R1/PIK3CB/BAD/HRAS/MSH3/BAK1/APPL1/RPS6KB2/MSH2/BRAF/RALB/JUN/CASP9/GADD45G/BIRC5/SOS2/FOS/RALA/BCL2L11/AXIN2/EGFR/RAC3/TGFB1/MAPK1/BAX/LEF1/AKT3/CDKN1A/AXIN1/DDB2/DCC/MAP2K1/EGF	62
KEGG	hsa05160	Hepatitis C	104/4078	157/8135	2.793e-05	0.0007176	0.0004998	YWHAE/TBK1/PPP2CA/PIK3CA/PPP2R2A/CASP3/MAP2K2/FAS/PPP2R1A/CYCS/IRF3/NFKB1/JAK1/NRAS/GSK3B/MYC/EIF2AK4/YWHAB/AKT1/TNF/AKT2/ARAF/SOS1/IRF9/CCND1/PIK3R2/KRAS/YWHAG/TP53/NR1H3/RIPK1/IFNG/GRB2/SCARB1/DDX58/CHUK/IFIT1/RXRA/CXCL10/PIK3R1/E2F3/PIK3CB/CLDN7/BAD/HRAS/IRF7/APAF1/YWHAH/BAK1/STAT2/IKBKB/EIF3E/CLDN2/BRAF/RB1/OAS1/PSME3/IFNA8/RSAD2/IFNAR1/STAT1/BID/CASP9/OAS2/CLDN5/CDK6/CLDN11/SOS2/CLDN8/IFNA16/EGFR/PPP2R2C/TRAF6/OCLN/EIF2AK2/MAVS/EIF2S1/PIAS1/MX2/YWHAZ/TLR3/EIF2AK3/MAPK1/CLDN10/IFNAR2/PPP2R2D/BAX/CLDN9/FASLG/SOCS3/CLDN16/AKT3/IFNB1/TRADD/RNASEL/OAS3/CDKN1A/CLDN18/CDK2/PPP2CB/MAP2K1/EGF/FADD/TRAF3	104
KEGG	hsa05169	Epstein-Barr virus infection	129/4078	202/8135	4.722e-05	0.001126	0.0007846	ITGAL/TBK1/MAP2K6/CD58/PIK3CA/CASP3/SAP30/MAP2K7/HDAC1/FAS/CYCS/MAPK8/PSMC6/IRF3/B2M/NFKB1/USP7/GADD45A/JAK1/CD3G/NFKBIB/ENTPD1/MYC/AKT1/TAPBP/TNF/AKT2/CD3E/SAP30L/BCL2/PSMD14/PSMC4/GADD45B/IRF9/CCND1/ICAM1/PIK3R2/RUNX3/HLA-G/PSMD12/TP53/HLA-E/RIPK1/CALR/DDX58/CHUK/HLA-B/SIN3A/NFKB2/MAPK14/CXCL10/TRAF5/PIK3R1/HLA-DRA/CCND2/RBPJL/E2F3/PSMD2/PIK3CB/JAK3/MDM2/IRF7/APAF1/PSMD1/BAK1/STAT2/VIM/IKBKB/NEDD4/RB1/OAS1/IFNA8/MAP2K4/HLA-C/CCNA2/IFNAR1/JUN/STAT1/BID/CASP9/GADD45G/OAS2/CD247/CDK6/ISG15/HLA-A/LYN/PSMD11/BCL2L11/HLA-DMB/CCNE2/CCNE1/IFNA16/PSMD8/PSMD3/RBPJ/TRAF6/NCOR2/IRAK1/EIF2AK2/PSMC3/MAVS/HDAC2/MYD88/HLA-DOB/MAPK13/PSMD6/MAPK12/IFNAR2/HLA-F/CD3D/FCER2/BAX/HLA-DPB1/TAP2/AKT3/CCND3/IFNB1/PSMD7/MAP3K7/TRADD/OAS3/CDKN1A/PSMD4/CDK2/DDB2/CD44/FADD/TRAF3	129
KEGG	hsa05132	Salmonella infection	155/4078	249/8135	6.203e-05	0.001381	0.000962	BRK1/TXN/M6PR/MAP2K6/LY96/PIK3CA/ACTR10/CASP3/RRAS/MAP2K7/MAP2K2/FLNB/CASP1/DYNLL2/CYCS/CDC42/PFN1/MAPK8/DYNLT1/DYNC1LI2/RAB5C/DCTN4/NFKB1/ARPC1B/KPNA4/BIRC2/MYL10/ARPC4/TXN2/DCTN6/CYFIP2/KPNA1/CYTH4/MYC/AKT1/MYL7/TCF7L2/TNF/RAB7A/AKT2/TUBA4A/ARL8B/VPS11/MYL12A/WASL/STX10/BCL2/PKN1/ARPC2/EXOC5/KIF5B/NLRC4/PIK3CG/FLNC/ARL8A/MYL12B/FYCO1/TNFSF10/TUBA8/TLR5/PIK3C2A/RIPK1/ACTB/ELMO2/IL18/CHUK/MAPK14/ARF1/DCTN5/CASP5/PFN4/PIK3CB/TNFRSF10A/RHOG/HRAS/TLR4/ACTR3B/ELMO1/RAB9B/DYNLT3/GSDMD/TUBB1/TUBB4B/BAK1/RIPK2/VPS33A/IKBKB/CYTH1/DYNC2LI1/RHOJ/ROCK2/ACTR3/MAP2K4/PODXL/DYNC1I2/JUN/CASP4/DYNLRB1/CYTH3/AHNAK/TUBB2B/FBXO22/CYTH2/TIRAP/VPS16/NOD1/FOS/SNX18/RALA/KIF5C/GAPDH/PIK3C2B/DYNC1LI1/SNX9/CXCL8/CSE1L/DYNLL1/RPS3/TRAF6/ARPC3/RAB5B/EXOC4/FHOD1/NCKAP1L/IRAK1/ANXA2/SNX33/ARF6/TUBA1A/KPNA3/MYD88/GCC2/KLC2/MYLPF/MAPK13/BIRC3/MAPK1/WASF3/MAPK12/SKP1/NCKAP1/BAX/LEF1/MYL2/HSP90AA1/ARPC5L/AKT3/MAP3K7/TRADD/TUBB3/TAB3/ABI1/DCTN3/MAP2K1/FADD	155
KEGG	hsa05165	Human papillomavirus infection	200/4078	331/8135	7.828e-05	0.001634	0.001138	SCRIB/TBK1/ATP6V1G1/PPP2CA/CHD4/PIK3CA/ATP6V1E1/PPP2R2A/PTGS2/ATP6V0A2/CASP3/UBR4/TADA3/HDAC1/MFNG/MAP2K2/FAS/PPP2R1A/ATP6V1C1/CDC42/CREB1/BCAP31/IRF3/NFKB1/PARD3/JAK1/MTOR/NRAS/TSC1/PPP2R5E/ATM/TBPL1/WNT9A/GSK3B/AKT1/ATP6V0B/TCF7L2/TNF/APC2/ITGAV/AKT2/HES2/SOS1/CRB3/ATP6V1D/PKM/IRF9/CCND1/MPP5/PIK3R2/WNT5A/KRAS/HLA-G/WNT7B/COL4A4/TP53/DVL1/MAML1/HLA-E/TNXB/PRKACB/TERT/CREB3L2/GRB2/WNT16/COL6A1/PRKCI/CHUK/HLA-B/NFX1/PRKACG/PIK3R1/LAMA4/CCND2/TNC/RBPJL/EP300/PIK3CB/HEYL/MAML2/LFNG/ITGA4/BAD/LAMA2/HRAS/MDM2/GNAS/ITGB4/PXN/HEY2/PRKACA/BAK1/STAT2/PTGER4/RPS6KB2/FOXO1/PARD6G/IKBKB/HES4/RB1/IFNA8/ITGB5/LAMC2/ATP6V0D1/PPP2R5A/LLGL1/HLA-C/CCNA2/IFNAR1/TCIRG1/PRKCZ/HES6/RBL2/WNT10A/STAT1/ATP6V1B1/MAML3/PPP2R5C/WNT6/ATP6V0E2/OASL/CDK6/WNT2/FZD6/LAMA1/ISG15/THBS3/HLA-A/NOTCH4/COL2A1/ITGA5/SOS2/EIF4EBP1/ITGA6/VWF/LAMB1/LLGL2/SLC9A3R1/ATP6V0A1/WNT8A/AXIN2/CCNE2/CCNE1/IFNA16/DVL2/ITGA3/TUBG1/RBPJ/TNR/EGFR/PPP2R2C/LAMB2/ITGA8/IBSP/EIF2AK2/SPP1/FZD10/COL4A3/ATP6V1H/FZD2/ITGA11/FZD7/HDAC2/MX2/IRF1/CREB3/TLR3/FZD5/MAPK1/COL9A2/DLG2/IFNAR2/HLA-F/PPP2R2D/BAX/ATP6V0D2/FASLG/PDGFRB/AKT3/CCND3/IFNB1/WNT7A/TRADD/CDKN1A/RFNG/UBE3A/PARD6A/AXIN1/NOTCH3/ITGA10/CDK2/HEY1/PPP2CB/MAP2K1/THBS2/EGF/WNT10B/WNT2B/FADD/TRAF3	200
KEGG	hsa04919	Thyroid hormone signaling pathway	81/4078	121/8135	0.0001227	0.002411	0.001679	PIK3CA/SLC16A10/HDAC1/MED1/MAP2K2/PFKM/NCOA2/MTOR/NRAS/KAT2A/GSK3B/MYC/PLCG1/AKT1/PDPK1/ITGAV/AKT2/ATP1B1/MED30/SLCO1C1/CCND1/PIK3R2/KRAS/RCAN1/NCOA3/KAT2B/HDAC3/HIF1A/TP53/PRKCB/PRKACB/ACTB/SIN3A/RXRA/PRKACG/PIK3R1/ATP1A1/EP300/PIK3CB/PLCB3/NCOA1/BAD/HRAS/MDM2/ATP2A3/ESR1/ATP2A1/PFKFB2/PRKACA/NCOR1/FOXO1/PLCD3/RXRG/MED4/ATP2A2/RXRB/SRC/THRA/STAT1/CASP9/PFKL/NOTCH4/ATP1B3/PLCB1/MED27/SLC16A2/HDAC2/MAPK1/PRKCG/ATP1A2/MED12/AKT3/FXYD2/MED14/RCAN2/NOTCH3/MED12L/ATP1A4/DIO1/MAP2K1/PLCE1	81
KEGG	hsa05220	Chronic myeloid leukemia	54/4078	76/8135	0.00016	0.002969	0.002068	PIK3CA/HDAC1/MAP2K2/NFKB1/GADD45A/NRAS/MYC/AKT1/AKT2/TGFBR2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/KRAS/TP53/GRB2/CHUK/SMAD3/TGFBR1/PIK3R1/E2F3/PIK3CB/CBL/BAD/HRAS/MDM2/BAK1/CRK/IKBKB/BRAF/RB1/ABL1/GADD45G/CDK6/BCL2L1/STAT5A/SOS2/SHC3/HDAC2/PTPN11/TGFB1/CTBP2/MAPK1/CDKN2A/BAX/SHC1/AKT3/CDKN1A/DDB2/BCR/MAP2K1/GAB2	54
KEGG	hsa05214	Glioma	53/4078	75/8135	0.0002302	0.004022	0.002801	PIK3CA/MAP2K2/CAMK1/GADD45A/MTOR/CALML4/NRAS/PDGFB/PLCG1/AKT1/AKT2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/KRAS/TP53/PRKCB/GRB2/PIK3R1/E2F3/PIK3CB/HRAS/MDM2/CALML5/BAK1/BRAF/RB1/CAMK2B/CAMK2A/GADD45G/PDGFRA/CDK6/SOS2/SHC3/CAMK1D/EGFR/CALM1/MAPK1/PRKCG/CDKN2A/BAX/SHC1/CAMK1G/PDGFRB/CAMK2G/AKT3/CDKN1A/DDB2/MAP2K1/EGF/PDGFA	53
KEGG	hsa05163	Human cytomegalovirus infection	139/4078	225/8135	0.0002408	0.004022	0.002801	ARHGEF1/NFATC3/TBK1/PTK2B/MAP2K6/AKAP13/PIK3CA/PTGS2/CASP3/MAP2K2/FAS/CYCS/GNAI2/GNB4/GNG2/GNGT2/CREB1/IRF3/B2M/NFKB1/GNG10/GNB1/JAK1/MTOR/CALML4/NRAS/TSC1/ITPR3/GSK3B/NFATC4/MYC/SP1/AKT1/TAPBP/TNF/ITGAV/AKT2/ATF2/RAC2/ITPR2/SOS1/CCND1/ADCY1/PIK3R2/KRAS/HLA-G/GNB5/TP53/NFATC1/PPP3CB/HLA-E/PRKCB/PRKACB/RIPK1/CREB3L2/GRB2/CALR/CCR5/CHUK/HLA-B/MAPK14/PRKACG/PPP3R1/TRAF5/PIK3R1/GNG5/GNB2/E2F3/PIK3CB/GNA11/PLCB3/GNB3/HRAS/MDM2/CX3CL1/GNAS/PXN/PRKACA/GNAI3/CALML5/BAK1/CRK/PTGER4/RPS6KB2/IKBKB/CXCR4/IL6R/GNA13/ROCK2/RB1/IFNA8/SRC/ROCK1/HLA-C/CXCR2/BID/CASP9/GNG4/PDGFRA/CDK6/PTGER1/PTGER3/HLA-A/SOS2/EIF4EBP1/ADCY9/ELK1/PLCB1/CXCL8/IFNA16/CCL5/ARHGEF11/NFATC2/EGFR/CALM1/RAC3/MAPK13/CREB3/MAPK1/GNA12/PRKCG/MAPK12/HLA-F/CDKN2A/BAX/ADCY3/FASLG/TAP2/AKT3/IFNB1/TRADD/CDKN1A/PPP3R2/BCAR1/PTGER2/ATF4/MAP2K1/GNGT1/FADD	139
KEGG	hsa04010	MAPK signaling pathway	176/4078	294/8135	0.0004033	0.006378	0.004442	NFATC3/TAOK3/JUND/MAP2K6/ARRB2/DUSP1/MAP4K4/CASP3/RRAS/LAMTOR3/CACNB2/MAP2K7/DUSP3/TAOK1/MAP2K2/FAS/FLNB/CDC42/NLK/MAPK8/PLA2G4A/NFKB1/GADD45A/NRAS/FLT4/PDGFB/DDIT3/CACNA2D2/CACNG8/MYC/MAP4K3/AKT1/TNF/AKT2/TGFBR2/ATF2/RAC2/CDC25B/NGFR/ARAF/GADD45B/SOS1/DUSP16/KRAS/DUSP9/ARRB1/MAX/FLNC/MEF2C/TP53/MAPT/NFATC1/PPP3CB/STK3/MAPK8IP2/PRKCB/PRKACB/GRB2/PGF/CHUK/NFKB2/MAPK14/PRKACG/PPP3R1/MAPKAPK2/TGFBR1/RASA2/RASGRP4/DUSP10/DUSP6/RASA1/CACNB1/RPS6KA3/CACNA1S/MAPK8IP3/HRAS/RPS6KA6/RASGRP2/FLT3LG/CACNA1I/HSPA6/DUSP5/PRKACA/CRK/EFNA5/IKBKB/RAP1B/BRAF/VEGFC/EFNA1/MAP2K4/FGF17/KITLG/HSPB1/JUN/FGF9/GADD45G/PDGFRA/HGF/PLA2G4F/PAK2/NTF3/NF1/MAPK8IP1/RRAS2/SOS2/EPHA2/FOS/CACNA1G/FGF16/EFNA4/FGF20/FGF21/ELK1/PPM1B/FGF19/CACNA1C/MAP4K2/EGFR/TRAF6/MAP3K12/IRAK1/CACNG4/STK4/ERBB3/HSPA1L/PTPN5/TAOK2/ANGPT1/MYD88/HSPA2/MRAS/RAC3/DAXX/MAPK13/TGFB1/MAPK1/GNA12/NR4A1/PRKCG/MAPK12/RPS6KA5/PLA2G4D/SRF/MAPKAPK3/CACNB3/RPS6KA1/PLA2G4C/FGF8/FLT1/FASLG/CACNA1B/PPM1A/INSR/PDGFRB/IL1RAP/PDGFC/AKT3/RASGRP1/CACNA1H/FGF5/CACNG2/MAP3K7/TRADD/RAPGEF2/MAPKAPK5/MAP3K11/CACNG5/PPP3R2/DUSP2/ATF4/MAP2K1/FGF18/EGF/PDGFA/INS	176
KEGG	hsa04068	FoxO signaling pathway	85/4078	131/8135	0.0004201	0.006378	0.004442	PIK3CA/MAP2K2/NLK/SOD2/MAPK8/USP7/GADD45A/NRAS/ATM/GABARAP/AKT1/PDPK1/AKT2/TGFBR2/PRKAB1/ARAF/GADD45B/SOS1/IL7R/CCND1/PIK3R2/KRAS/TNFSF10/HOMER3/GRB2/PRKAG1/CHUK/MAPK14/SMAD3/TGFBR1/PIK3R1/CCND2/EP300/PIK3CB/AGAP2/CCNB2/PRKAA2/HRAS/MDM2/ATG12/FOXO6/PRKAA1/GABARAPL2/FOXO1/IKBKB/BRAF/CDKN2B/PLK3/SIRT1/RBL2/RAG1/GADD45G/FOXG1/PRKAG2/PCK2/PRMT1/SOS2/BCL2L11/BCL6/EGFR/STK4/S1PR1/PRKAB2/CCNG2/MAPK13/TGFB1/MAPK1/MAPK12/CDKN2D/PLK2/CCNB1/PRKAG3/FASLG/INSR/AKT3/IRS4/FOXO3/CDKN1A/S1PR4/CDK2/KLF2/GABARAPL1/MAP2K1/EGF/INS	85
KEGG	hsa01524	Platinum drug resistance	51/4078	73/8135	0.0004692	0.006814	0.004746	ATP7A/PIK3CA/CASP3/FAS/CYCS/BIRC2/GSTO1/ATM/AKT1/PDPK1/AKT2/PMAIP1/BCL2/PIK3R2/TP53/ATP7B/PIK3R1/PIK3CB/BAD/MDM2/MSH3/APAF1/GSTM1/BAK1/BRCA1/MSH2/BID/CASP9/BCL2L1/BIRC5/GSTA3/GSTM4/XPA/XIAP/POLH/BIRC3/GSTM2/MAPK1/GSTP1/MGST3/CDKN2A/BAX/REV3L/FASLG/TOP2B/AKT3/GSTO2/CDKN1A/GSTA1/TOP2A/FADD	51
KEGG	hsa05226	Gastric cancer	95/4078	149/8135	0.0004941	0.006876	0.004789	PIK3CA/MAP2K2/GADD45A/MTOR/NRAS/WNT9A/GSK3B/MYC/AKT1/TCF7L2/APC2/AKT2/TGFBR2/ARAF/BCL2/GADD45B/SOS1/CCND1/PIK3R2/WNT5A/KRAS/SMAD2/WNT7B/TP53/DVL1/TERT/GRB2/WNT16/SMAD3/RXRA/TGFBR1/PIK3R1/ABCB1/E2F3/PIK3CB/HRAS/BAK1/RPS6KB2/BRAF/RXRG/RB1/RXRB/FGF17/CDKN2B/SHH/FRAT2/FGF9/WNT10A/WNT6/GADD45G/HGF/WNT2/FZD6/SOS2/FGF16/FGF20/FGF21/WNT8A/SHC3/FGF19/AXIN2/CCNE2/CCNE1/DVL2/EGFR/FZD10/CTNNA2/FZD2/FZD7/MUC2/TGFB1/FZD5/MAPK1/CTNNA1/CDH1/BAX/LEF1/FGF8/SHC1/AKT3/CDH17/WNT7A/FGF5/LRP6/RARB/CDKN1A/AXIN1/GAB1/CDK2/DDB2/MAP2K1/FGF18/EGF/WNT10B/WNT2B	95
KEGG	hsa04917	Prolactin signaling pathway	49/4078	70/8135	0.0005616	0.007502	0.005225	PIK3CA/MAP2K2/SOCS7/MAPK8/NFKB1/JAK2/NRAS/CGA/GSK3B/AKT1/AKT2/SOS1/CCND1/PIK3R2/KRAS/GRB2/MAPK14/PIK3R1/SOCS4/CCND2/PIK3CB/SOCS1/HRAS/GALT/ESR1/PRLR/SRC/CYP17A1/STAT1/SOCS6/STAT5A/SOCS5/SOS2/FOS/SOCS2/GCK/SHC3/IRF1/MAPK13/MAPK1/ELF5/MAPK12/SHC1/SOCS3/AKT3/LHCGR/FOXO3/MAP2K1/INS	49
KEGG	hsa05162	Measles	89/4078	139/8135	0.0005998	0.007705	0.005367	TBK1/PIK3CA/CASP3/FAS/CSNK2A2/IL2RG/CYCS/MAPK8/IRF3/NFKB1/IFIH1/JAK1/CD3G/NFKBIB/GSK3B/EIF2AK4/AKT1/AKT2/CD3E/CD46/BCL2/IRF9/CCND1/PIK3R2/RCHY1/CD28/TP53/CSNK2A1/DDX58/CHUK/PIK3R1/CCND2/PIK3CB/JAK3/IL2RB/BAD/FCGR2B/IRF7/APAF1/TLR4/HSPA6/RAB9B/CLEC4M/CD209/BAK1/STAT2/IKBKB/ADAR/MSN/OAS1/IFNA8/IFNAR1/JUN/STAT1/BID/CASP9/OAS2/CDK6/BCL2L1/STAT5A/TLR7/FOS/CCNE2/CCNE1/IFNA16/TRAF6/IRAK1/EIF2AK2/HSPA1L/MAVS/EIF2S1/MYD88/HSPA2/MX2/EIF2AK3/IFNAR2/CD3D/BAX/FASLG/AKT3/CCND3/IFNB1/MAP3K7/TRADD/OAS3/CDK2/CBLB/FADD/TRAF3	89
KEGG	hsa05225	Hepatocellular carcinoma	105/4078	168/8135	0.000744	0.009203	0.00641	SMARCA4/SMARCC1/PIK3CA/MAP2K2/SMARCD2/GSTO1/GADD45A/MTOR/NRAS/WNT9A/GSK3B/MYC/PLCG1/AKT1/TCF7L2/ARID1B/APC2/AKT2/TGFBR2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/WNT5A/KRAS/SMAD2/WNT7B/TP53/DVL1/PRKCB/ACTB/TERT/GRB2/HMOX1/WNT16/SMAD3/TGFBR1/PIK3R1/E2F3/PIK3CB/SMARCD3/BAD/SMARCC2/HRAS/GSTM1/BAK1/RPS6KB2/BRAF/RB1/ARID1A/BRD7/FRAT2/WNT10A/WNT6/GADD45G/SMARCA2/HGF/CDK6/BCL2L1/WNT2/FZD6/GSTA3/SOS2/GSTM4/WNT8A/ELK1/SHC3/AXIN2/SMARCD1/DVL2/EGFR/PBRM1/ACTL6B/FZD10/FZD2/FZD7/TGFB1/FZD5/GSTM2/MAPK1/GSTP1/PRKCG/MGST3/NFE2L2/KEAP1/CDKN2A/SMARCB1/BAX/LEF1/SHC1/AKT3/WNT7A/GSTO2/LRP6/ACTL6A/CDKN1A/TXNRD1/AXIN1/GAB1/GSTA1/DDB2/MAP2K1/WNT10B/WNT2B	105
KEGG	hsa05231	Choline metabolism in cancer	65/4078	98/8135	0.0008187	0.009766	0.006802	SLC22A3/PIK3CA/DGKD/MAP2K2/WASF2/MAPK8/PLA2G4A/MTOR/NRAS/TSC1/PDGFB/PLCG1/SP1/AKT1/DGKG/PDPK1/AKT2/RAC2/SOS1/PCYT1A/PIK3R2/KRAS/HIF1A/CHKB/GPCPD1/PRKCB/GRB2/DGKA/PIK3R1/SLC44A5/PIK3CB/LYPLA1/SLC44A1/HRAS/SLC22A4/PIP5K1B/WASF1/RPS6KB2/JUN/PLD2/PDGFRA/PLA2G4F/SOS2/EIF4EBP1/FOS/DGKE/EGFR/SLC22A2/SLC44A3/CHPT1/RAC3/DGKK/MAPK1/PIP5K1C/WASF3/PRKCG/PLA2G4D/PCYT1B/PLA2G4C/PDGFRB/PDGFC/AKT3/MAP2K1/EGF/PDGFA	65
KEGG	hsa05170	Human immunodeficiency virus 1 infection	129/4078	212/8135	0.0009541	0.01099	0.007654	NFATC3/TBK1/PTK2B/MAP2K6/PIK3CA/RBX1/RNF7/CASP3/MAP2K7/MAP2K2/FAS/AP1S1/CYCS/GNAI2/GNB4/GNG2/MAPK8/CFL1/GNGT2/AP1S2/IRF3/B2M/NFKB1/GNG10/TNFRSF1B/GNB1/MTOR/CD3G/CALML4/NRAS/ATM/ITPR3/NFATC4/PLCG1/AKT1/TAPBP/TNF/AKT2/RAC2/CD3E/BCL2/ITPR2/CUL4B/PIK3R2/KRAS/HLA-G/GNB5/NFATC1/PPP3CB/HLA-E/PRKCB/RIPK1/CALR/CCR5/CHUK/HLA-B/MAPK14/PPP3R1/TRAF5/PIK3R1/GNG5/GNB2/AP1M1/PIK3CB/CD4/GNA11/CCNB2/BAD/GNB3/HRAS/TLR4/PXN/GNAI3/CALML5/BAK1/CRK/RPS6KB2/IKBKB/CXCR4/CDC25C/IFNA8/HLA-C/APOBEC3G/JUN/BID/CASP9/GNG4/CD247/PAK2/BCL2L1/SAMHD1/HLA-A/DDB1/CDK1/FOS/AP1M2/IFNA16/NFATC2/TRAF6/IRAK1/CUL5/CALM1/AP1G1/MYD88/RAC3/MAPK13/MAPK1/PRKCG/MAPK12/HLA-F/SKP1/CD3D/CCNB1/BAX/AP1G2/FASLG/TAP2/AKT3/IFNB1/TRIM5/MAP3K7/TRADD/AP1B1/AP1S3/PPP3R2/CUL4A/MAP2K1/GNGT1/FADD	129
KEGG	hsa05135	Yersinia infection	87/4078	137/8135	0.001009	0.01123	0.007821	ARHGEF1/NFATC3/TBK1/PTK2B/MAP2K6/PIK3CA/MAP2K7/MAP2K2/CASP1/CDC42/WASF2/MAPK8/IRF3/NFKB1/ARPC1B/LAT/ARPC4/GSK3B/PLCG1/AKT1/TNF/PKN2/AKT2/RAC2/WASL/PKN1/DOCK1/PIK3R2/ARPC2/NLRC4/NFATC1/VAV3/MEFV/ACTB/ELMO2/IL18/CHUK/MAPK14/PIK3R1/PIK3CB/CD4/RPS6KA3/ITGA4/RHOG/RPS6KA6/TLR4/ACTR3B/ELMO1/PXN/PIP5K1B/CRK/WIPF2/IKBKB/ROCK2/ACTR3/GIT2/SRC/MAP2K4/VAV1/ROCK1/JUN/CD8A/ITGA5/FOS/CXCL8/NFATC2/TRAF6/ARPC3/IRAK1/WIPF1/FCGR2A/ARF6/MYD88/RAC3/MAPK13/LCK/MAPK1/PIP5K1C/MAPK12/RPS6KA1/ARPC5L/AKT3/IFNB1/MAP3K7/ARHGEF7/BCAR1/MAP2K1	87
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	38/4078	53/8135	0.001128	0.0118	0.008216	CLTB/AP2M1/AP2B1/ATP1B1/AP2S1/ATP2B3/PRKCB/PRKACB/RAB11A/PRKACG/CLTC/ATP1A1/CALB1/PLCB3/AP2A2/ESR1/GNAS/KL/PRKACA/SLC8A1/CLTA/ATP1B3/ATP2B4/ADCY9/PLCB1/VDR/DNM3/ATP2B1/KLK1/AP2A1/PRKCG/ATP1A2/PTH1R/FXYD2/SLC8A2/ATP1A4/KLK2/TRPV5	38
KEGG	hsa04660	T cell receptor signaling pathway	68/4078	104/8135	0.00113	0.0118	0.008216	NFATC3/PIK3CA/CARD11/MAP2K7/MAP2K2/CDC42/MAPK8/NFKB1/LAT/CD3G/NFKBIB/BCL10/NRAS/GSK3B/PLCG1/PTPN6/AKT1/NCK1/TNF/PDPK1/AKT2/CD3E/NCK2/SOS1/MALT1/PIK3R2/KRAS/CD28/NFATC1/VAV3/PPP3CB/IFNG/GRB2/PDCD1/CHUK/MAPK14/PPP3R1/PIK3R1/PIK3CB/CD4/IL5/HRAS/IKBKB/ICOS/VAV1/JUN/CD8A/GRAP2/CD247/PAK2/TEC/SOS2/FOS/CSF2/NFATC2/PRKCQ/MAPK13/LCK/MAPK1/MAPK12/CD3D/AKT3/RASGRP1/MAP3K7/CD40LG/PPP3R2/CBLB/MAP2K1	68
KEGG	hsa05222	Small cell lung cancer	61/4078	92/8135	0.001187	0.01201	0.008367	CKS2/BIRC7/PIK3CA/PTGS2/CASP3/CKS1B/CYCS/NFKB1/BIRC2/GADD45A/MYC/AKT1/ITGAV/AKT2/BCL2/GADD45B/CCND1/PIK3R2/MAX/COL4A4/TP53/CHUK/RXRA/TRAF5/PIK3R1/LAMA4/E2F3/PIK3CB/LAMA2/APAF1/BAK1/IKBKB/ZBTB17/RXRG/RB1/LAMC2/RXRB/CDKN2B/CASP9/GADD45G/CDK6/BCL2L1/LAMA1/ITGA6/LAMB1/FHIT/CCNE2/CCNE1/ITGA3/TRAF6/LAMB2/COL4A3/XIAP/BIRC3/BAX/AKT3/RARB/CDKN1A/CDK2/DDB2/TRAF3	61
KEGG	hsa03060	Protein export	19/4078	23/8135	0.001335	0.01311	0.009132	HSPA5/SEC61B/SRP14/SPCS3/IMMP1L/SEC11A/SEC61G/SEC11C/SEC62/SRP68/SEC61A1/SRP19/SRP9/IMMP2L/SRP72/SRPRB/SEC63/SPCS1/SPCS2	19
KEGG	hsa04921	Oxytocin signaling pathway	96/4078	154/8135	0.001391	0.01327	0.009246	MYL6/NFATC3/PTGS2/CACNB2/MAP2K2/GNAI2/CAMK1/PLA2G4A/KCNJ4/CAMKK2/CALML4/NRAS/ITPR3/CACNA2D2/NFATC4/CACNG8/PIK3R5/PRKAB1/ITPR2/CCND1/ADCY1/KRAS/RCAN1/PIK3CG/NOS3/MEF2C/NPPA/NFATC1/PPP3CB/OXTR/PRKCB/PRKACB/ACTB/PPP1R12A/PRKAG1/PPP1CB/KCNJ2/PRKACG/PPP3R1/RGS2/PPP1CA/PLCB3/CACNB1/PRKAA2/RYR3/CACNA1S/HRAS/MYL6B/GNAS/PRKAA1/PRKACA/GNAI3/CALML5/PIK3R6/KCNJ3/KCNJ14/ROCK2/SRC/CAMK2B/ROCK1/JUN/CAMK2A/KCNJ5/PLA2G4F/PPP1R12C/PRKAG2/MYLK3/FOS/ADCY9/ELK1/PLCB1/CACNA1C/CAMK1D/NFATC2/EGFR/CACNG4/CALM1/PRKAB2/KCNJ6/MAPK1/CD38/PRKCG/PLA2G4D/ADCY3/CACNB3/PLA2G4C/PRKAG3/CAMK1G/CAMK2G/CACNG2/CDKN1A/PPP1R12B/NPR2/CACNG5/PPP3R2/MAP2K1	96
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	83/4078	131/8135	0.00144	0.01336	0.009308	ITGAL/PTK2B/PIK3CA/CASP3/FCER1G/MAP2K2/FAS/CD48/LAT/NRAS/PLCG1/PTPN6/TNF/RAC2/ARAF/SOS1/ICAM1/PIK3R2/KRAS/HLA-G/IFNGR1/KIR2DS4/TNFSF10/NFATC1/VAV3/PPP3CB/HLA-E/PRKCB/IFNG/GRB2/HLA-B/PPP3R1/KLRC3/PIK3R1/PIK3CB/HCST/ULBP2/TNFRSF10A/HRAS/SH2D1A/KIR2DL3/BRAF/IFNA8/TYROBP/KIR3DL3/VAV1/HLA-C/IFNAR1/BID/CD247/KIR2DL2/HLA-A/SOS2/KIR2DS3/CSF2/MICA/SHC3/KIR2DL1/IFNA16/NFATC2/KIR2DS1/ULBP3/KIR2DS2/NCR2/PTPN11/RAC3/LCK/MAPK1/PRKCG/IFNAR2/KIR2DS5/SH2D1B/GZMB/RAET1E/FASLG/SHC1/ICAM2/IFNB1/MICB/PPP3R2/MAP2K1/FCGR3B/KLRD1	83
KEGG	hsa05218	Melanoma	49/4078	72/8135	0.001514	0.01367	0.00952	PIK3CA/MAP2K2/GADD45A/NRAS/PDGFB/AKT1/AKT2/ARAF/GADD45B/CCND1/PIK3R2/KRAS/TP53/PIK3R1/E2F3/PIK3CB/BAD/HRAS/MDM2/BAK1/BRAF/RB1/FGF17/FGF9/GADD45G/PDGFRA/HGF/CDK6/MITF/FGF16/FGF20/FGF21/FGF19/EGFR/MAPK1/CDKN2A/CDH1/BAX/FGF8/PDGFRB/PDGFC/AKT3/FGF5/CDKN1A/DDB2/MAP2K1/FGF18/EGF/PDGFA	49
KEGG	hsa04213	Longevity regulating pathway - multiple species	43/4078	62/8135	0.001625	0.01376	0.009583	PIK3CA/HDAC1/SOD2/ATG5/MTOR/NRAS/AKT1/AKT2/PRKAB1/ADCY1/PIK3R2/KRAS/PRKACB/PRKAG1/PRKACG/PIK3R1/PIK3CB/CRYAB/PRKAA2/RPTOR/HRAS/HSPA6/PRKAA1/PRKACA/RPS6KB2/FOXO1/SIRT1/PRKAG2/AKT1S1/ADCY9/HSPA1L/PRKAB2/HDAC2/HSPA2/EIF4EBP2/ADCY3/SOD1/PRKAG3/INSR/AKT3/IRS4/FOXO3/INS	43
KEGG	hsa03018	RNA degradation	53/4078	79/8135	0.001637	0.01376	0.009583	EXOSC3/LSM1/PABPC3/PAN2/SKIV2L/PFKM/EXOSC1/EXOSC10/CNOT6L/EDC4/LSM7/C1D/LSM3/DDX6/LSM5/XRN1/LSM8/PARN/DCP1B/CNOT1/ENO1/CNOT8/HSPA9/ZCCHC7/BTG3/CNOT10/PABPC1/LSM6/PABPC4L/EXOSC6/PFKL/WDR61/DCPS/DCP2/PAN3/BTG2/EDC3/MPHOSPH6/CNOT6/DIS3L/XRN2/NUDT16/EXOSC4/PNPT1/PABPC5/EXOSC2/HSPD1/DCP1A/TOB2/ENO3/DIS3/CNOT4/BTG4	53
KEGG	hsa05131	Shigellosis	147/4078	247/8135	0.001648	0.01376	0.009583	TBK1/PIK3CA/RBX1/FNBP1/UBC/CAPN2/CASP1/CYCS/CDC42/WASF2/PFN1/MAPK8/UBE2N/ATG5/IRF3/NFKB1/ARPC1B/CAPN1/UBE2D4/MTOR/MYL10/NFKBIB/ARPC4/UBE2NL/BCL10/ATM/ITPR3/CYTH4/GSK3B/PLCG1/ILK/AKT1/MYL7/TNF/CAPNS1/AKT2/UBE2V2/MYL12A/WASL/BCL2/ITPR2/DOCK1/MALT1/PIK3R2/ARPC2/NLRC4/RRAGC/MYL12B/TP53/HKDC1/TLR5/HK3/RIPK1/ACTB/ELMO2/IL18/CHUK/MAPK14/VCL/ARF1/TIFA/TRAF5/PIK3R1/PFN4/PIK3CB/PLCB3/HCLS1/RPTOR/MDM2/ATG12/FOXO6/TLR4/TNIP1/ACTR3B/ELMO1/BECN1/MAP1LC3A/TLN2/PXN/WASF1/CRK/ACTN4/RIPK2/RNF31/RPS6KB2/FOXO1/IKBKB/MAP1LC3B/CYTH1/UBA52/ARHGEF2/PLCD3/ROCK2/U2AF1L4/ACTR3/GLMN/SRC/CBX3/ROCK1/JUN/CASP4/CYTH3/BCL2L1/CYTH2/ITGA5/NOD1/CSF2/AKT1S1/RRAGA/PLCB1/CXCL8/CCL5/EGFR/TRAF6/ARPC3/SHARPIN/PRKCQ/PRKCD/ARF6/HK1/MYD88/RBCK1/MYLPF/MAPK13/RRAGB/MAP1LC3C/MAPK1/SQSTM1/DIAPH1/MAPK12/VDAC1/RPS6KA5/SKP1/UBB/BAX/MYL2/RPS27A/ARPC5L/AKT3/IFNB1/MAP3K7/TRADD/FOXO3/TAB3/BCAR1/CD44/PLCE1	147
KEGG	hsa00410	beta-Alanine metabolism	24/4078	31/8135	0.001711	0.01394	0.009709	GADL1/DPYD/ALDH9A1/CSAD/ALDH3A1/ALDH3A2/ALDH6A1/ECHS1/MLYCD/SMOX/ACADS/ABAT/AOC2/HIBCH/ALDH2/UPB1/CNDP2/GAD1/ALDH1B1/ALDH3B1/HADHA/DPYS/ACOX1/ALDH3B2	24
KEGG	hsa04962	Vasopressin-regulated water reabsorption	32/4078	44/8135	0.001884	0.01498	0.01043	ARHGDIB/DYNLL2/DYNC1LI2/CREB1/RAB5C/DCTN4/STX4/DCTN6/ARHGDIA/PRKACB/CREB3L2/RAB11A/PRKACG/DCTN5/GNAS/AQP4/PRKACA/DYNC2LI1/RAB11B/DYNC1I2/VAMP2/ADCY9/DYNC1LI1/NSF/DYNLL1/RAB5B/CREB3/AVP/ADCY3/ARHGDIG/AQP3/AVPR2	32
KEGG	hsa03050	Proteasome	33/4078	46/8135	0.002335	0.01768	0.01231	PSMA2/PSMA4/PSMC6/POMP/PSMD14/PSMC4/PSMD12/PSMD9/IFNG/PSMB1/PSMB6/PSMD2/PSMD1/PSMB8/PSME3/PSMA5/PSMA7/PSME4/PSMB2/PSMD11/PSMB5/PSME1/PSMA3/PSMB7/PSMD8/PSMD3/PSMC3/PSMD6/PSMB9/PSMA8/PSMD7/PSMA1/PSMD4	33
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	269/4078	476/8135	0.002351	0.01768	0.01231	UQCRQ/VCP/PSMA2/NDUFB3/NDUFA4/COX7A2/TBK1/MAP2K6/SDHA/C9orf72/ACTR10/HSPA5/PTGS2/COX7C/COX7B/CASP3/UBC/CAPN2/MAP2K7/ATXN1L/MAP2K2/SDHC/FAS/CSNK2A2/COX7A2L/CYCS/NDUFS3/NDUFB2/PSMA4/MAPK8/PSMC6/NDUFA6/DCTN4/NFKB1/CAPN1/TNFRSF1B/UQCRC1/UQCR11/NDUFA5/MTOR/NDUFB6/HAP1/UQCR10/CALML4/SIGMAR1/NRAS/DCTN6/COX5B/TARDBP/RB1CC1/ITPR3/COX6C/DDIT3/WNT9A/GSK3B/NDUFS2/PLCG1/NDUFA1/MFN1/TNF/APC2/XBP1/TUBA4A/ATXN2L/MCU/COX1/ARAF/BCL2/PSMD14/PSMC4/HTRA2/ITPR2/NDUFV2/GPX2/WNT5A/KRAS/NDUFA13/NDUFS4/PSMD12/GRIN2C/KIF5B/LRRK2/NDUFS7/WNT7B/PSMD9/MFN2/NEFM/DVL1/COX6A1/MAPT/GPX3/TUBA8/DNAH9/PPP3CB/PRKCB/SLC25A4/CSNK2A1/WNT16/MAPK14/UQCRB/PPP3R1/NDUFA2/SMCR8/PSMB1/DNAL4/PSMB6/HSD17B10/DCTN5/NDUFS1/RAB8A/TRAP1/PSMD2/COX6A2/PLCB3/VDAC2/COX2/BAD/RYR3/CACNA1S/HRAS/NDUFV1/UBE2L3/PARK7/ATP2A3/NOX1/APAF1/ULK2/DLG4/UBA1/BECN1/MAP1LC3A/TUBB1/ATP2A1/GRIN2B/PSMD1/TUBB4B/CALML5/BAK1/ATP6/UBE2J1/HTT/MAP1LC3B/DNAH5/UBA52/NDUFAB1/BRAF/CDK5R1/ATXN2/ATP2A2/PSMA5/SLC25A6/CAMK2B/TANK/CHMP2B/NDUFA4L2/COX7A1/FRAT2/GRM5/DKK2/PSMA7/PDYN/WNT10A/BID/CASP9/CAMK2A/WNT6/DNAH1/UQCRFS1/NEFH/NDUFB5/TUBB2B/BCL2L1/ATG13/WNT2/FZD6/DNAH7/DKK4/PSMB2/CDK5/RAB39B/PSMD11/PSMB5/PSMA3/DNAH2/KIF5C/COX5A/NDUFS6/WNT8A/PSMB7/PLCB1/CACNA1C/AXIN2/PSMD8/DVL2/TOMM40/PSMD3/PPIF/UBE2L6/ATG101/FZD10/SPG11/NDUFB4/GPR37/CASP12/CALM1/ZFYVE1/GRIN2D/GRIN2A/PSMC3/FZD2/EIF2S1/TUBA1A/FZD7/KLC2/DAXX/MAPK13/PSMD6/MAP1LC3C/FZD5/UQCRC2/EIF2AK3/MAPK1/GRIA4/SQSTM1/NDUFB8/PRKCG/MAPK12/VDAC1/COX8A/PSMA8/UBB/BAX/COX6B1/SOD1/NDUFC1/RPS27A/FASLG/CACNA1B/WDR41/SLC25A31/AGER/CAMK2G/WNT7A/PSMD7/LRP6/NEFL/SNCAIP/GPX5/GPX8/APP/RAB1A/TUBB3/NOX4/COX4I2/PSMA1/NDUFA8/AXIN1/PPP3R2/PSMD4/ERN1/ATF4/ATXN3/UBE2J2/DCTN3/MAP2K1/TOMM40L/WNT10B/WNT2B/FADD	269
KEGG	hsa04115	p53 signaling pathway	49/4078	73/8135	0.002382	0.01768	0.01231	CASP3/FAS/CYCS/MDM4/GADD45A/PIDD1/ATM/RRM2B/PMAIP1/BCL2/GADD45B/CCND1/RCHY1/SHISA5/TP53/PPM1D/CCND2/TNFRSF10A/CCNB2/MDM2/APAF1/IGFBP3/SERPINE1/TP53I3/RRM2/TP53AIP1/CD82/BID/CASP9/GADD45G/CDK6/BCL2L1/CDK1/GORAB/CHEK2/CCNE2/STEAP3/CCNE1/GTSE1/SIVA1/CCNG2/CDKN2A/CCNB1/BAX/CCND3/CDKN1A/CDK2/DDB2/AIFM2	49
KEGG	hsa05205	Proteoglycans in cancer	123/4078	205/8135	0.002555	0.01837	0.0128	ARHGEF1/PIK3CA/CASP3/RRAS/MAP2K2/FAS/FLNB/CDC42/DROSHA/MTOR/NRAS/ITPR3/WNT9A/MYC/PLCG1/PTPN6/NUDT16L1/AKT1/TNF/PDPK1/ITGAV/AKT2/ARAF/HBEGF/ITPR2/SOS1/CCND1/PIK3R2/WNT5A/KRAS/SMAD2/WNT7B/FLNC/HIF1A/TP53/VAV3/PRKCB/PRKACB/ACTB/MMP2/GRB2/PPP1R12A/WNT16/PPP1CB/MAPK14/PRKACG/IQGAP1/PIK3R1/HPSE/PIK3CB/PPP1CA/EZR/CBL/HCLS1/HRAS/MDM2/TLR4/ESR1/PXN/PRKACA/CAV3/CTSL/RPS6KB2/BRAF/ROCK2/MSN/ITGB5/SRC/CAMK2B/VAV1/ROCK1/SHH/WNT10A/CAMK2A/WNT6/HGF/PPP1R12C/ANK1/WNT2/FZD6/RRAS2/ITGA5/SOS2/HSPB2/WNT8A/ELK1/RDX/EGFR/FRS2/GPC3/FZD10/ERBB3/FZD2/ANK2/FZD7/HSPG2/PTPN11/MRAS/PDCD4/MAPK13/TGFB1/FZD5/MAPK1/PRKCG/MAPK12/FASLG/TIMP3/SDC1/CAMK2G/AKT3/WNT7A/CDKN1A/PLAUR/SMO/PPP1R12B/GAB1/TIAM1/DDX5/CD44/MAP2K1/WNT10B/PLCE1/WNT2B	123
KEGG	hsa05014	Amyotrophic lateral sclerosis	209/4078	364/8135	0.002586	0.01837	0.0128	POM121C/UQCRQ/VCP/PSMA2/NDUFB3/NDUFA4/NUP50/COX7A2/TBK1/MAP2K6/SDHA/C9orf72/UBQLN4/ACTR10/HSPA5/COX7C/COX7B/CASP3/NUP188/SDHC/COX7A2L/CASP1/ANXA7/CYCS/MATR3/ANXA11/NXT2/NDUFS3/PFN1/NDUFB2/PSMA4/PSMC6/NDUFA6/DCTN4/TNFRSF1B/UQCRC1/UQCR11/NDUFA5/MTOR/NDUFB6/HAP1/NUP93/UQCR10/SIGMAR1/DCTN6/COX5B/TARDBP/RB1CC1/ITPR3/COX6C/DDIT3/NDUFS2/NDUFA1/TNF/XBP1/TUBA4A/POM121/ATXN2L/MCU/COX1/SRSF3/BCL2/PSMD14/PSMC4/NDUFV2/GPX2/HNRNPA3/NDUFA13/NDUFS4/PSMD12/GRIN2C/KIF5B/NDUFS7/NUP37/PSMD9/NEFM/TP53/COX6A1/GPX3/TUBA8/DNAH9/PPP3CB/ACTB/MAPK14/UQCRB/PPP3R1/NDUFA2/SMCR8/GLE1/PSMB1/DNAL4/PSMB6/UBQLN1/UBQLN2/DCTN5/NDUFS1/RAB8A/PFN4/PSMD2/COX6A2/COX2/BAD/NDUFV1/HNRNPA1/APAF1/ULK2/BECN1/MAP1LC3A/TUBB1/GRIN2B/PSMD1/TUBB4B/ATP6/NUP210/MAP1LC3B/DNAH5/NDUFAB1/ATXN2/PSMA5/RAE1/RANBP2/TANK/CHMP2B/NDUFA4L2/COX7A1/ALYREF/PSMA7/BID/NCBP1/CASP9/ANG/DNAH1/UQCRFS1/NEFH/NDUFB5/TUBB2B/BCL2L1/ATG13/DNAH7/HDAC6/NRG1/PSMB2/CHCHD10/RAB39B/PSMD11/PSMB5/PSMA3/DNAH2/SETX/KIF5C/COX5A/NDUFS6/SRSF7/PSMB7/PSMD8/TOMM40/PSMD3/UBQLN3/ATG101/SPG11/NDUFB4/CASP12/GRIN2D/GRIN2A/PSMC3/EIF2S1/TUBA1A/SEC13/KLC2/NUP214/DAXX/MAPK13/PSMD6/NUP153/MAP1LC3C/UQCRC2/EIF2AK3/NUP35/SQSTM1/NDUFB8/MAPK12/VDAC1/COX8A/PSMA8/BAX/COX6B1/SOD1/NDUFC1/NXF3/WDR41/PSMD7/NEFL/GPX5/NUP205/GPX8/RAB1A/TUBB3/COX4I2/PSMA1/NUP210L/NDUFA8/NUP98/PPP3R2/PSMD4/ERN1/ATF4/DCTN3/NRG4/TOMM40L	209
KEGG	hsa04120	Ubiquitin mediated proteolysis	88/4078	142/8135	0.00277	0.01928	0.01343	ANAPC15/BIRC7/RBX1/RNF7/VHL/UBC/PRPF19/UBE2I/FANCL/UBE2N/HUWE1/UBE2S/UBE2W/BIRC2/UBE2D4/UBA3/UBE2NL/UBE2B/PPIL2/ANAPC10/CUL4B/HERC4/RCHY1/ANAPC11/UBE2A/CUL3/CBLC/FBXO4/UBE4B/ERCC8/SAE1/UBE2M/TRIM37/PIAS2/CDC27/CBL/UBE2O/MID1/SOCS1/MDM2/UBE2L3/SMURF2/UBE2E1/UBA6/UBA1/ANAPC5/UBE2J1/BRCA1/UBR5/UBA52/NEDD4/ANAPC2/UBE2E2/ANAPC13/AIRE/HERC1/ITCH/UBE2K/DDB1/PML/TRAF6/DET1/UBE2L6/RHOBTB2/CUL5/KLHL9/CDC26/XIAP/RHOBTB1/PIAS1/UBE2H/BIRC3/SMURF1/KEAP1/SKP1/FBXW8/UBB/UBE2Z/STUB1/RPS27A/SOCS3/UBE3A/DDB2/CUL4A/UBE2J2/CBLB/UBE2F/CUL2	88
KEGG	hsa05216	Thyroid cancer	27/4078	37/8135	0.003927	0.0264	0.01839	CCDC6/MAP2K2/TFG/GADD45A/NRAS/MYC/TCF7L2/GADD45B/CCND1/KRAS/TP53/RXRA/HRAS/BAK1/BRAF/RXRG/PAX8/RXRB/NCOA4/GADD45G/MAPK1/CDH1/BAX/LEF1/CDKN1A/DDB2/MAP2K1	27
KEGG	hsa05212	Pancreatic cancer	50/4078	76/8135	0.004073	0.0264	0.01839	PIK3CA/CDC42/MAPK8/NFKB1/GADD45A/JAK1/MTOR/AKT1/AKT2/TGFBR2/RAC2/ARAF/GADD45B/CCND1/PIK3R2/KRAS/SMAD2/TP53/CHUK/SMAD3/TGFBR1/PIK3R1/E2F3/PIK3CB/BAD/BAK1/RPS6KB2/IKBKB/BRAF/RB1/RALB/PLD2/STAT1/CASP9/GADD45G/CDK6/BCL2L1/BRCA2/RALA/EGFR/RAC3/TGFB1/MAPK1/CDKN2A/BAX/AKT3/CDKN1A/DDB2/MAP2K1/EGF	50
KEGG	hsa04810	Regulation of actin cytoskeleton	129/4078	218/8135	0.004084	0.0264	0.01839	BRK1/ARHGEF1/ITGAL/SSH1/PIK3CA/RRAS/MAP2K2/CDC42/WASF2/PFN1/CFL1/ARPC1B/MYL10/ARPC4/NRAS/CYFIP2/TMSB4Y/PDGFB/MYL7/APC2/ITGAV/RAC2/MYL12A/WASL/ARAF/SOS1/DOCK1/ITGAE/MYH14/PIK3R2/FGD3/KRAS/ARPC2/MYL12B/VAV3/ACTB/PPP1R12A/MYH11/PPP1CB/VCL/PIP4K2B/MYH9/IQGAP1/PIK3R1/PFN4/PIK3CB/PPP1CA/EZR/ITGA4/GSN/HRAS/FGD1/KNG1/ACTR3B/ITGB4/PXN/PIP5K1B/PIP4K2C/WASF1/CRK/ACTN4/CXCR4/BRAF/GNA13/ROCK2/MSN/ACTR3/ITGB5/SPATA13/SRC/FGF17/VAV1/ROCK1/SSH2/FGF9/PDGFRA/PPP1R12C/PAK2/ABI2/MYLK3/RRAS2/ITGA5/SOS2/ITGA6/IQGAP3/FGF16/FGF20/FGF21/PIP4K2A/FGF19/TMSB4X/ITGA3/RDX/EGFR/ARPC3/SSH3/NCKAP1L/ITGA8/ITGA11/MRAS/RAC3/MYLPF/BDKRB1/LPAR1/MAPK1/GNA12/PIP5K1C/DIAPH1/ARHGAP35/NCKAP1/MYL2/SCIN/ARHGEF4/FGF8/ARPC5L/PDGFRB/PDGFC/FGF5/ARHGEF7/PPP1R12B/ITGA10/TIAM1/BCAR1/MAP2K1/FGF18/GIT1/EGF/PDGFA/INS	129
KEGG	hsa05012	Parkinson disease	155/4078	266/8135	0.004111	0.0264	0.01839	UQCRQ/TXN/PSMA2/NDUFB3/NDUFA4/COX7A2/SDHA/HSPA5/DUSP1/COX7C/COX7B/CASP3/SLC39A7/UBC/SDHC/COX7A2L/CYCS/GNAI2/NDUFS3/NDUFB2/PSMA4/MAPK8/PSMC6/NDUFA6/UQCRC1/UQCR11/NDUFA5/NDUFB6/TXN2/UQCR10/CALML4/COX5B/ITPR3/COX6C/DDIT3/NDUFS2/PLCG1/NDUFA1/MFN1/XBP1/TUBA4A/MCU/COX1/PSMD14/PSMC4/HTRA2/ITPR2/NDUFV2/SLC39A10/NDUFA13/NDUFS4/PSMD12/KIF5B/LRRK2/NDUFS7/PSMD9/MFN2/TP53/COX6A1/MAPT/TUBA8/SLC39A13/PRKACB/SLC25A4/SLC39A5/PRKACG/UQCRB/NDUFA2/PSMB1/PSMB6/NDUFS1/TRAP1/PSMD2/COX6A2/VDAC2/COX2/RYR3/NDUFV1/UBE2L3/PARK7/APAF1/GNAS/UBA1/TUBB1/PRKACA/GNAI3/PSMD1/TUBB4B/CALML5/ATP6/UBE2J1/UBA52/NDUFAB1/PSMA5/SLC25A6/CAMK2B/NDUFA4L2/COX7A1/PSMA7/CASP9/CAMK2A/UQCRFS1/NDUFB5/TUBB2B/BCL2L1/PSMB2/PSMD11/PSMB5/DRD2/PSMA3/KIF5C/COX5A/NDUFS6/PSMB7/PSMD8/PSMD3/PPIF/UBE2L6/NDUFB4/GPR37/CALM1/PSMC3/EIF2S1/TUBA1A/KLC2/DAXX/PSMD6/UQCRC2/EIF2AK3/NDUFB8/VDAC1/NFE2L2/KEAP1/COX8A/PSMA8/UBB/BAX/COX6B1/SOD1/NDUFC1/SLC39A8/RPS27A/SLC25A31/CAMK2G/PSMD7/SNCAIP/SLC39A2/TUBB3/COX4I2/PSMA1/NDUFA8/PSMD4/ERN1/ATF4/UBE2J2	155
KEGG	hsa04929	GnRH secretion	43/4078	64/8135	0.004199	0.02646	0.01843	ARRB2/PIK3CA/MAP2K2/HCN3/NRAS/HCN2/ITPR3/CGA/AKT1/AKT2/ITPR2/PIK3R2/KRAS/ARRB1/PRKCB/PIK3R1/PIK3CB/GNA11/PLCB3/CACNA1S/HRAS/CACNA1I/KCNJ3/TRPC1/KCNJ5/TRPC4/CACNA1G/KCNN4/KCNN1/PLCB1/CACNA1C/SPP1/GNRH2/KISS1/KCNJ6/MAPK1/PRKCG/KCNJ11/AKT3/CACNA1H/GABBR2/MAP2K1/KCNN3	43
KEGG	hsa04370	VEGF signaling pathway	40/4078	59/8135	0.004454	0.02755	0.01919	PIK3CA/PTGS2/MAP2K2/CDC42/PLA2G4A/NRAS/PLCG1/AKT1/AKT2/RAC2/PIK3R2/KRAS/NOS3/PPP3CB/PRKCB/MAPK14/PPP3R1/MAPKAPK2/PIK3R1/PIK3CB/BAD/HRAS/PXN/SRC/HSPB1/CASP9/PLA2G4F/NFATC2/RAC3/MAPK13/SH2D2A/MAPK1/PRKCG/MAPK12/PLA2G4D/MAPKAPK3/PLA2G4C/AKT3/PPP3R2/MAP2K1	40
KEGG	hsa04012	ErbB signaling pathway	55/4078	85/8135	0.004552	0.02764	0.01925	PIK3CA/MAP2K7/MAP2K2/MAPK8/MTOR/NRAS/GSK3B/MYC/PLCG1/AKT1/NCK1/AKT2/NCK2/ARAF/HBEGF/SOS1/PIK3R2/KRAS/PRKCB/GRB2/PIK3R1/BTC/PIK3CB/CBL/BAD/HRAS/CRK/RPS6KB2/BRAF/SRC/MAP2K4/ABL1/CAMK2B/JUN/CAMK2A/PAK2/STAT5A/NRG1/SOS2/EIF4EBP1/ELK1/SHC3/EGFR/ERBB3/MAPK1/PRKCG/SHC1/CAMK2G/AKT3/CDKN1A/GAB1/CBLB/NRG4/MAP2K1/EGF	55
KEGG	hsa05130	Pathogenic Escherichia coli infection	117/4078	197/8135	0.005144	0.03068	0.02137	BRK1/ARHGEF1/CASP3/SEC24C/FAS/CASP1/CYCS/CDC42/WASF2/MAPK8/NFKB1/ARPC1B/NFKBIB/ARPC4/CYFIP2/CYTH4/PTPN6/NCK1/TNF/TUBA4A/ABCF2/NCK2/WASL/MYH14/ARPC2/TMED10/TJP1/TNFSF10/TUBA8/TLR5/RIPK1/ACTB/MYH11/IL18/CHUK/MAPK14/ARF1/MYH9/CLDN7/EZR/TNFRSF10A/HCLS1/TLR4/ACTR3B/TUBB1/TUBB4B/BAK1/WASF1/WIPF2/MYO1C/IKBKB/CYTH1/ARHGEF2/CLDN2/GNA13/ROCK2/ACTR3/SRC/ABL1/ROCK1/SEC24D/JUN/CASP4/MYO5B/CASP9/CLDN5/CYTH3/TUBB2B/PAK2/CLDN11/CYTH2/TIRAP/FOS/GAPDH/SLC9A3R1/CLDN8/CXCL8/MYO1E/RPS3/ARHGEF11/TRAF6/ARPC3/OCLN/NCKAP1L/IRAK1/WIPF1/FCGR2A/ARF6/TUBA1A/MYD88/PTPN11/MAPK13/NCL/LPAR1/MAPK1/CLDN10/GNA12/WASF3/MAPK12/NCKAP1/MYO1B/BAX/CLDN9/FASLG/ARPC5L/CLDN16/MAP3K7/SEC24A/TRADD/RAB1A/TUBB3/MYO1H/TAB3/CLDN18/SEC24B/ABI1/FADD	117
KEGG	hsa04146	Peroxisome	53/4078	82/8135	0.005482	0.03189	0.02221	AGPS/PEX2/PEX13/SOD2/PXMP4/PEX19/DECR2/PRDX5/HSD17B4/FAR1/CRAT/MVK/MPV17/PEX16/MLYCD/ECH1/PEX11B/ABCD4/PEX5/HMGCL/PRDX1/SLC25A17/ACOX2/ECI2/ABCD1/PEX5L/ACSL3/NUDT19/BAAT/AMACR/PEX14/SLC27A2/HMGCLL1/PECR/PEX7/GSTK1/PEX12/PEX11A/EPHX2/ABCD3/FAR2/ABCD2/SOD1/ACSL5/CROT/PEX26/PEX3/DAO/IDH1/PXMP2/PEX6/PHYH/ACOX1	53
KEGG	hsa05168	Herpes simplex virus 1 infection	276/4078	495/8135	0.005538	0.03189	0.02221	ZNF350/TBK1/PIK3CA/ZNF585A/ZNF562/ZNF587/ZNF785/CASP3/ZNF222/ZNF544/SRSF5/ZNF615/FAS/ZNF230/ZNF205/CYCS/ZNF611/ZNF316/ZNF221/ZNF8/ZNF808/HCFC2/IRF3/B2M/NFKB1/IFIH1/BIRC2/ZNF793/JAK1/MTOR/ZNF101/JAK2/ZNF780A/ZNF557/ZNF57/TSC1/ZNF786/HCFC1/ZNF777/EIF2AK4/ZNF573/ZNF267/AKT1/TAPBP/POU2F2/TNF/ZNF184/AKT2/ZNF791/SRPK1/ZNF248/ZNF100/SRSF3/BCL2/IRF9/PIK3R2/ZNF688/ZNF383/HLA-G/IFNGR1/ZNF2/EIF2B1/ZNF74/ZNF765/ZNF160/TP53/ZNF226/ZNF566/ZNF302/HLA-E/ZNF764/IFNG/ZNF268/CD74/CALR/PPP1CB/DDX58/CHUK/HLA-B/C5/ZNF506/TRAF5/PIK3R1/ZNF140/ZNF77/ZNF605/ZNF627/HLA-DRA/ZNF684/ZNF229/ZNF324/ZNF597/ZNF432/ZNF227/PIK3CB/ZFP69/PPP1CA/ZNF33B/ZNF490/ZNF571/BAD/ZNF584/ZNF519/IRF7/EIF2B5/APAF1/ZNF614/ZNF107/ZNF253/ZNF235/ZNF492/ZNF484/ZNF570/BAK1/ZNF26/STAT2/ZNF17/ZNF853/ZNF708/ZNF554/ZNF84/IKBKB/ZNF468/ZNF180/ZFP92/OAS1/IFNA8/ZNF528/ZNF200/ZNF619/ZNF564/ZNF630/SRC/ZNF398/HLA-C/ZNF169/ZNF99/IFNAR1/ALYREF/ZNF879/STAT1/BID/ZNF596/CASP9/ZNF257/ZNF550/ZNF44/OAS2/ZNF225/ZNF624/ZNF577/ZNF680/ZNF709/ZNF93/ZNF814/BCL2L1/ZNF569/ZNF175/ZNF470/ZNF658/HLA-A/ZNF563/ZNF549/ZNF700/SRSF1/ITGA5/EIF4EBP1/ZNF783/CFP/SRSF7/PML/ZNF471/ZNF311/ZNF713/ZNF607/ZNF891/HLA-DMB/IFNA16/ZNF124/ZNF669/ZNF404/ZNF671/ZNF701/CCL5/ZNF426/ZNF610/ZNF514/TRAF6/ZNF25/ZNF620/EIF2B3/IRAK1/ZNF717/ZNF780B/SRSF4/EIF2AK2/ZNF510/ZNF567/ZNF670/ZNF585B/ZNF486/ZNF334/ZNF254/ZNF45/ZNF214/MAVS/ZNF136/EIF2S1/ZSCAN32/ZNF155/ZNF141/ZNF354A/ZNF273/MYD88/PTPN11/HLA-DOB/ZNF3/EIF2B2/ZNF558/SRSF8/ZNF275/ZNF224/LTA/DAXX/BIRC3/TLR3/ZNF480/ZNF556/EIF2AK3/ZNF195/ZNF212/IFNAR2/HLA-F/ZNF613/ZFP57/BAX/ZNF675/ZNF546/ZNF282/ZNF823/ZIM3/FASLG/HLA-DPB1/ZNF112/NXF3/ZNF836/TAP2/SOCS3/ZNF416/AKT3/IFNB1/ZNF430/ZIK1/MAP3K7/TRADD/ZNF14/RNASEL/OAS3/ZNF132/ZNF682/ZFP69B/ZNF10/ZNF300/ZNF677/ZNF718/ZNF530/ZNF90/ZNF649/ZNF354C/ZNF721/ZNF583/ZNF439/TNFRSF14/ZNF441/FADD/TRAF3	276
KEGG	hsa04062	Chemokine signaling pathway	114/4078	192/8135	0.005768	0.03265	0.02274	PTK2B/ARRB2/PIK3CA/CDC42/GNAI2/GNB4/GNG2/GNGT2/NFKB1/GNG10/PARD3/GNB1/NFKBIB/JAK2/NRAS/GSK3B/PLCG1/AKT1/AKT2/RAC2/PIK3R5/CCL13/SOS1/HCK/ADCY1/PIK3R2/KRAS/ARRB1/GNB5/PIK3CG/FGR/CXCL16/VAV3/CCL20/PRKCB/PRKACB/GRB2/CCR5/CHUK/PRKACG/CXCL10/PIK3R1/GNG5/GNB2/PIK3CB/JAK3/PLCB3/GRK1/CXCL9/BAD/GRK6/GNB3/HRAS/CCR2/RASGRP2/CX3CL1/CXCR6/ELMO1/PXN/PRKACA/CXCL5/GNAI3/PIK3R6/CRK/STAT2/IKBKB/RAP1B/CXCR4/BRAF/ROCK2/CCR7/SRC/CCR10/VAV1/ROCK1/PRKCZ/CXCR2/STAT1/GNG4/CXCL6/LYN/SOS2/CCL27/ADCY9/CCL18/CCL21/SHC3/PLCB1/CCL16/CXCL8/CCL5/CCL23/CCL22/PRKCD/CCL26/RAC3/PF4/MAPK1/CCL19/CXCL1/ADCY3/PF4V1/SHC1/AKT3/CXCR1/FOXO3/PREX1/TIAM1/BCAR1/PPBP/GRK5/CCL24/MAP2K1/GNGT1	114
KEGG	hsa05219	Bladder cancer	29/4078	41/8135	0.005923	0.03297	0.02296	MAP2K2/NRAS/MYC/ARAF/HBEGF/CCND1/KRAS/TP53/MMP2/RASSF1/E2F3/HRAS/MDM2/BRAF/TYMP/RB1/SRC/DAPK1/CXCL8/EGFR/DAPK3/MAPK1/RPS6KA5/CDKN2A/CDH1/MMP1/CDKN1A/MAP2K1/EGF	29
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	130/4078	222/8135	0.006501	0.03548	0.02471	ITGAL/ANAPC15/NFATC3/PIK3CA/MAP2K2/IL2RG/MAPK8/SPI1/CREB1/B2M/NFKB1/JAK1/CD3G/NRAS/POLB/ATM/KAT2A/TBPL1/NFATC4/MYC/AKT1/MMP7/TNF/AKT2/TGFBR2/ATF2/CD3E/IL15/ANAPC10/CCND1/ADCY1/ICAM1/PIK3R2/KRAS/ANAPC11/HLA-G/NFYB/SMAD2/KAT2B/TP53/NFATC1/PPP3CB/HLA-E/PRKACB/TERT/CREB3L2/SLC25A4/CALR/CHUK/HLA-B/NFKB2/SMAD3/PRKACG/PPP3R1/TGFBR1/PIK3R1/HLA-DRA/CCND2/E2F3/EP300/PIK3CB/JAK3/CDC27/CD4/VDAC2/CCNB2/CDKN2C/IL2RB/HRAS/RANBP3/TLN2/ANAPC5/ETS1/PRKACA/GPS2/MAD2L1/IKBKB/RB1/ANAPC2/PTTG1/MAP2K4/ZFP36/CDKN2B/SLC25A6/HLA-C/ANAPC13/CCNA2/JUN/MSX2/BCL2L1/STAT5A/HLA-A/TCF3/LTBR/FOS/CSF2/ADCY9/ELK1/HLA-DMB/CHEK2/CCNE2/CCNE1/NFATC2/CDC26/XIAP/HLA-DOB/LTA/TGFB1/CREB3/LCK/MAPK1/EGR1/VDAC1/HLA-F/CD3D/CDKN2A/SRF/BAX/ADCY3/HLA-DPB1/EGR2/SLC25A31/AKT3/CCND3/CRTC3/CDKN1A/PPP3R2/CDK2/ATF4/MAP2K1	130
KEGG	hsa04137	Mitophagy - animal	47/4078	72/8135	0.006586	0.03548	0.02471	TBK1/RRAS/UBC/TAX1BP1/CITED2/CSNK2A2/MAPK8/ATG5/RHOT1/NRAS/TFE3/GABARAP/SP1/MFN1/RAB7A/TBC1D15/USP8/KRAS/HIF1A/MFN2/TP53/PGAM5/CSNK2A1/HRAS/GABARAPL2/BECN1/MAP1LC3A/MAP1LC3B/UBA52/SRC/JUN/BCL2L1/RHOT2/RRAS2/FIS1/MITF/TBC1D17/MRAS/MAP1LC3C/EIF2AK3/SQSTM1/UBB/RPS27A/FOXO3/FUNDC1/ATF4/GABARAPL1	47
KEGG	hsa05224	Breast cancer	89/4078	147/8135	0.006704	0.03554	0.02476	PIK3CA/MAP2K2/GADD45A/MTOR/NRAS/FLT4/WNT9A/GSK3B/MYC/SP1/AKT1/TCF7L2/APC2/AKT2/ARAF/GADD45B/SOS1/CCND1/PIK3R2/WNT5A/KRAS/NCOA3/WNT7B/TP53/DVL1/GRB2/WNT16/NFKB2/PIK3R1/E2F3/PIK3CB/HEYL/NCOA1/HRAS/ESR1/HEY2/BAK1/PGR/RPS6KB2/BRCA1/DLL3/BRAF/RB1/FGF17/FRAT2/JUN/FGF9/WNT10A/WNT6/GADD45G/CDK6/WNT2/FZD6/NOTCH4/BRCA2/SOS2/FOS/FGF16/FGF20/FGF21/WNT8A/SHC3/FGF19/AXIN2/DVL2/EGFR/FZD10/FZD2/FZD7/FZD5/MAPK1/BAX/LEF1/FGF8/SHC1/AKT3/WNT7A/FGF5/LRP6/CDKN1A/AXIN1/NOTCH3/DDB2/HEY1/MAP2K1/FGF18/EGF/WNT10B/WNT2B	89
KEGG	hsa00280	Valine, leucine and isoleucine degradation	33/4078	48/8135	0.006842	0.0357	0.02487	DLD/IL4I1/ALDH9A1/IVD/ALDH3A2/BCAT2/ALDH6A1/OXCT2/AUH/MCEE/ECHS1/ACAT2/HMGCS1/HSD17B10/ACADM/BCAT1/HADHB/HMGCL/ACADS/ABAT/MCCC2/ACADSB/HMGCLL1/HIBCH/MCCC1/BCKDHA/AACS/ALDH2/PCCA/AOX1/ALDH1B1/HADHA/AGXT2	33
KEGG	hsa04130	SNARE interactions in vesicular transport	24/4078	33/8135	0.006953	0.03573	0.02489	STX7/YKT6/STX5/VAMP7/VAMP5/STX8/SEC22B/STX4/STX11/VAMP4/STX6/VAMP3/VAMP1/STX18/VTI1B/BNIP1/SNAP23/GOSR1/BET1/VAMP8/VAMP2/SNAP29/GOSR2/USE1	24
KEGG	hsa05221	Acute myeloid leukemia	44/4078	67/8135	0.007184	0.03609	0.02514	PIK3CA/MAP2K2/BCL2A1/SPI1/NFKB1/MTOR/NRAS/MYC/AKT1/TCF7L2/AKT2/ARAF/FCGR1A/SOS1/CCND1/PIK3R2/KRAS/GRB2/CHUK/PIK3R1/DUSP6/PIK3CB/BAD/HRAS/PIM2/RPS6KB2/IKBKB/BRAF/CEBPA/CCNA2/PIM1/STAT5A/SOS2/EIF4EBP1/CSF2/PML/RARA/RUNX1T1/MAPK1/LEF1/AKT3/MPO/PPARD/MAP2K1	44
KEGG	hsa05164	Influenza A	102/4078	171/8135	0.00724	0.03609	0.02514	TBK1/PIK3CA/CASP3/MAP2K2/FAS/CASP1/CYCS/NXT2/IRF3/NFKB1/IFIH1/TPSB2/JAK1/NFKBIB/JAK2/KPNA1/AKT1/TNF/AKT2/IRF9/ICAM1/PIK3R2/DNAJC3/IFNGR1/TNFSF10/PRKCB/ACTB/IFNG/SLC25A4/RAB11A/DDX58/IL18/CHUK/CXCL10/PIK3R1/HLA-DRA/EP300/PIK3CB/KPNA6/TPSAB1/TNFRSF10A/PRSS2/CPSF4/IRF7/APAF1/TLR4/BAK1/STAT2/IL33/IKBKB/ADAR/PRSS3/OAS1/IFNA8/RAB11B/RSAD2/RAE1/SLC25A6/CIITA/IFNAR1/STAT1/BID/CASP9/OAS2/KPNA5/CDK6/TLR7/KPNA2/PML/HLA-DMB/CXCL8/IFNA16/CCL5/TMPRSS2/DNAJB1/EIF2AK2/MAVS/EIF2S1/MYD88/HLA-DOB/MX2/TLR3/MAPK1/VDAC1/IFNAR2/BAX/FASLG/HLA-DPB1/NXF3/SLC25A31/SOCS3/AKT3/CCND3/IFNB1/HNRNPUL1/TRADD/RNASEL/OAS3/NUP98/MAP2K1/FADD/TRAF3	102
KEGG	hsa04621	NOD-like receptor signaling pathway	109/4078	184/8135	0.007532	0.03699	0.02577	YWHAE/TXN/TBK1/CASP1/CARD16/MAPK8/ATG5/IRF3/NFKB1/CARD8/BIRC2/JAK1/NFKBIB/TXN2/ITPR3/GABARAP/MFN1/TNF/PKN2/MCU/AIM2/BCL2/ITPR2/PKN1/IRF9/PYDC1/NLRC4/MFN2/MEFV/RIPK1/IL18/CHUK/TRPV2/MAPK14/TRAF5/NAMPT/CASP5/GBP4/PLCB3/VDAC2/IRF7/ATG12/TLR4/PANX1/GABARAPL2/MAP1LC3A/GSDMD/ANTXR2/DEFA5/RIPK2/STAT2/NLRP6/RNF31/IKBKB/MAP1LC3B/CARD6/OAS1/IFNA8/TANK/IFNAR1/JUN/CASP4/DEFA4/STAT1/NLRP1/OAS2/GBP3/BCL2L1/CAMP/NOD1/PSTPIP1/SUGT1/PLCB1/CXCL8/IFNA16/CCL5/P2RX7/TRAF6/SHARPIN/CASP12/XIAP/PRKCD/MAVS/DHX33/MYD88/RBCK1/MAPK13/BIRC3/MAP1LC3C/CASR/MAPK1/MAPK12/VDAC1/IFNAR2/CXCL1/GBP5/DEFA6/NOD2/HSP90AA1/BRCC3/IFNB1/MAP3K7/RNASEL/OAS3/TAB3/ANTXR1/GABARAPL1/FADD/TRAF3	109
KEGG	hsa04726	Serotonergic synapse	71/4078	115/8135	0.007703	0.03729	0.02597	DUSP1/PTGS2/CASP3/GNAI2/GNB4/GNG2/PLA2G4A/GNGT2/GNG10/GNB1/NRAS/ITPR3/ARAF/SLC6A4/CYP4X1/ITPR2/KRAS/GNB5/PTGS1/PRKCB/PRKACB/GABRB2/PRKACG/GNG5/GNB2/PLCB3/HTR5A/CACNA1S/GNB3/HRAS/GNAS/PRKACA/GNAI3/KCNJ3/RAPGEF3/BRAF/ALOX5/DDC/TRPC1/HTR1A/TPH1/GNG4/KCNJ5/PLA2G4F/CYP2D6/KCND2/HTR1E/ALOX12B/PLCB1/CACNA1C/GABRB3/HTR1F/KCNJ6/HTR7/MAPK1/PRKCG/PLA2G4D/HTR2C/PLA2G4C/HTR2A/CACNA1B/APP/ALOX12/GABRB1/HTR1D/CYP2C9/HTR3B/HTR1B/HTR6/MAP2K1/GNGT1	71
KEGG	hsa05010	Alzheimer disease	216/4078	384/8135	0.008024	0.03827	0.02666	UQCRQ/APH1A/PSMA2/NDUFB3/NDUFA4/COX7A2/SDHA/PIK3CA/PTGS2/COX7C/COX7B/CASP3/SLC39A7/CAPN2/MAP2K7/MAP2K2/SDHC/FAS/CSNK2A2/COX7A2L/CYCS/NDUFS3/NDUFB2/PSMA4/MAPK8/PSMC6/NDUFA6/NFKB1/CAPN1/UQCRC1/UQCR11/NDUFA5/MTOR/NDUFB6/UQCR10/CALML4/NRAS/COX5B/RB1CC1/ITPR3/COX6C/DDIT3/WNT9A/GSK3B/NDUFS2/AKT1/NDUFA1/TNF/APC2/AKT2/XBP1/TUBA4A/MCU/COX1/ARAF/PSMD14/PSMC4/ITPR2/NDUFV2/PIK3R2/WNT5A/KRAS/SLC39A10/NDUFA13/NDUFS4/PSMD12/GRIN2C/KIF5B/NDUFS7/WNT7B/PSMD9/APBB1/DVL1/COX6A1/MAPT/TUBA8/PPP3CB/SLC39A13/SLC25A4/SLC39A5/CSNK2A1/WNT16/CHUK/UQCRB/ADAM10/PPP3R1/NDUFA2/PSMB1/PIK3R1/PSMB6/HSD17B10/NDUFS1/PSMD2/PIK3CB/COX6A2/PLCB3/VDAC2/COX2/NCSTN/BAD/RYR3/CACNA1S/HRAS/NDUFV1/ATP2A3/NOX1/APAF1/ULK2/BECN1/TUBB1/ATP2A1/GRIN2B/PSMD1/TUBB4B/CALML5/ATP6/IKBKB/NDUFAB1/BRAF/CDK5R1/ATP2A2/PSMA5/SLC25A6/NDUFA4L2/COX7A1/FRAT2/GRM5/DKK2/PSMA7/WNT10A/BID/CASP9/WNT6/UQCRFS1/NDUFB5/TUBB2B/ATG13/WNT2/FZD6/DKK4/PSENEN/PSMB2/CDK5/PSMD11/PSMB5/PSMA3/KIF5C/GAPDH/COX5A/NDUFS6/WNT8A/NAE1/PSMB7/PLCB1/CACNA1C/AXIN2/PSMD8/DVL2/PSMD3/PPIF/APH1B/APOE/ATG101/EIF2AK2/FZD10/NDUFB4/CASP12/CALM1/GRIN2D/GRIN2A/PSMC3/FZD2/EIF2S1/TUBA1A/FZD7/KLC2/PSMD6/FZD5/UQCRC2/EIF2AK3/MAPK1/MME/NDUFB8/VDAC1/COX8A/PSMA8/RTN4/COX6B1/NDUFC1/SLC39A8/INSR/SLC25A31/AGER/AKT3/WNT7A/PSMD7/LRP6/APP/IRS4/SLC39A2/TUBB3/NOX4/COX4I2/PSMA1/NDUFA8/AXIN1/RTN3/PPP3R2/PSMD4/ERN1/ATF4/MAP2K1/WNT10B/WNT2B/FADD/INS	216
KEGG	hsa04110	Cell cycle	77/4078	126/8135	0.008136	0.03827	0.02666	YWHAE/ANAPC15/CCNH/RBX1/HDAC1/ORC4/GADD45A/ATM/GSK3B/MYC/YWHAB/ORC6/STAG1/CDC25B/ANAPC10/GADD45B/CCND1/ANAPC11/SMAD2/YWHAG/TTK/TP53/MAD2L2/SMAD3/CCND2/E2F3/EP300/CDC27/CCNB2/CDKN2C/MDM2/BUB1/E2F4/ANAPC5/YWHAH/SMC1A/MAD2L1/ZBTB17/CDC25C/RB1/ANAPC2/PTTG1/CDKN2B/ORC2/ABL1/ANAPC13/CCNA2/RBL2/GADD45G/CDK6/E2F5/CDK1/CHEK2/CCNE2/CCNE1/CDC26/CDC45/PCNA/HDAC2/YWHAZ/TGFB1/CDKN2D/ORC3/SKP1/SMC1B/CDKN2A/CCNB1/RAD21/MCM7/CCND3/CDKN1A/ORC1/SMC3/CDK2/CDK7/DBF4/CDC6	77
KEGG	hsa04910	Insulin signaling pathway	83/4078	137/8135	0.008444	0.03917	0.02728	FASN/PIK3CA/FLOT2/MAP2K2/FLOT1/MAPK8/MTOR/CALML4/NRAS/TSC1/GSK3B/AKT1/PDPK1/AKT2/PRKAB1/ACACB/ARAF/PRKAR2A/SOS1/PIK3R2/KRAS/INPP5A/HKDC1/SORBS1/HK3/PRKACB/GRB2/PRKAG1/PRKCI/PPP1CB/PRKACG/PPP1R3B/PIK3R1/SOCS4/PIK3CB/PPP1CA/CBL/PRKAA2/BAD/RPTOR/SOCS1/HRAS/RHOQ/PRKAA1/INPPL1/PRKACA/CALML5/CRK/RPS6KB2/FOXO1/IKBKB/PPP1R3D/BRAF/PRKCZ/PRKAG2/PCK2/PPARGC1A/SOS2/EIF4EBP1/SOCS2/PPP1R3F/GCK/ELK1/SHC3/CALM1/HK1/PRKAB2/PYGM/MAPK1/GYS2/FBP2/EIF4E/PRKAG3/SHC1/INSR/SOCS3/AKT3/IRS4/PDE3B/SREBF1/CBLB/MAP2K1/INS	83
KEGG	hsa04722	Neurotrophin signaling pathway	73/4078	119/8135	0.008641	0.03954	0.02754	YWHAE/PIK3CA/ARHGDIB/MAP2K7/MAP2K2/CDC42/MAPK8/MAGED1/NFKB1/NFKBIB/CALML4/NRAS/SH2B1/GSK3B/PLCG1/AKT1/PDPK1/AKT2/NGFR/BCL2/ARHGDIA/SOS1/PIK3R2/KRAS/TP53/GRB2/IRAK3/MAPK14/MAPKAPK2/PIK3R1/PIK3CB/SORT1/RPS6KA3/BAD/HRAS/RPS6KA6/CALML5/CRK/RIPK2/IKBKB/RAP1B/BRAF/ZNF274/ABL1/CAMK2B/JUN/CAMK2A/NTF3/SOS2/SHC3/TRAF6/FRS2/IRAK1/PRDM4/CALM1/PRKCD/PTPN11/MAPK13/MAPK1/MAPK12/RPS6KA5/BAX/ARHGDIG/RPS6KA1/FASLG/SHC1/CAMK2G/AKT3/FOXO3/GAB1/ATF4/MAP2K1/KIDINS220	73
KEGG	hsa04211	Longevity regulating pathway	56/4078	89/8135	0.009895	0.04466	0.03111	PIK3CA/SOD2/CREB1/ATG5/CAMKK2/NFKB1/MTOR/NRAS/TSC1/RB1CC1/AKT1/AKT2/ATF2/PRKAB1/ADCY1/PIK3R2/KRAS/TP53/PRKACB/CREB3L2/PRKAG1/ADIPOQ/PRKACG/PIK3R1/PIK3CB/PRKAA2/RPTOR/HRAS/PRKAA1/KL/PRKACA/APPL1/RPS6KB2/FOXO1/SIRT1/ATG13/PRKAG2/PPARGC1A/EIF4EBP1/AKT1S1/ADCY9/ADIPOR2/ATG101/PRKAB2/CREB3/BAX/ADCY3/EIF4E/PRKAG3/EHMT2/INSR/AKT3/IRS4/FOXO3/ATF4/INS	56
KEGG	hsa01522	Endocrine resistance	61/4078	98/8135	0.01015	0.04494	0.0313	PIK3CA/MED1/MAP2K2/MAPK8/MTOR/BIK/NRAS/SP1/AKT1/AKT2/ARAF/HBEGF/BCL2/SOS1/CCND1/ADCY1/PIK3R2/KRAS/NCOA3/TP53/PRKACB/MMP2/GRB2/MAPK14/PRKACG/PIK3R1/E2F3/PIK3CB/CDKN2C/BAD/HRAS/MDM2/ESR1/GNAS/PRKACA/NCOR1/RPS6KB2/DLL3/BRAF/RB1/SRC/JUN/CYP2D6/NOTCH4/SOS2/FOS/ADCY9/SHC3/EGFR/ABCB11/MAPK13/MAPK1/MAPK12/CDKN2A/BAX/ADCY3/SHC1/AKT3/CDKN1A/NOTCH3/MAP2K1	61
KEGG	hsa04662	B cell receptor signaling pathway	52/4078	82/8135	0.01023	0.04494	0.0313	NFATC3/PIK3CA/CARD11/MAP2K2/LILRA6/NFKB1/NFKBIB/BCL10/NRAS/GSK3B/PTPN6/AKT1/AKT2/RAC2/LILRA1/SOS1/MALT1/PIK3R2/KRAS/CD79A/CD79B/NFATC1/VAV3/PPP3CB/PRKCB/GRB2/CHUK/IFITM1/PPP3R1/PIK3R1/PIK3AP1/PIK3CB/HRAS/FCGR2B/INPPL1/IKBKB/VAV1/JUN/LILRA2/LYN/SOS2/FOS/NFATC2/INPP5D/RAC3/MAPK1/CD22/AKT3/LILRA4/LILRB4/PPP3R2/MAP2K1	52
KEGG	hsa04912	GnRH signaling pathway	58/4078	93/8135	0.01136	0.04926	0.03431	PTK2B/MAP2K6/MAP2K7/MAP2K2/CDC42/MAPK8/PLA2G4A/CALML4/NRAS/ITPR3/CGA/HBEGF/ITPR2/SOS1/ADCY1/KRAS/PRKCB/PRKACB/MMP2/GRB2/MAPK14/PRKACG/GNA11/PLCB3/CACNA1S/HRAS/GNAS/PRKACA/CALML5/SRC/MAP2K4/CAMK2B/JUN/PLD2/CAMK2A/PLA2G4F/SOS2/ADCY9/ELK1/PLCB1/CACNA1C/EGFR/CALM1/GNRH2/PRKCD/GNRHR/MAPK13/MAPK1/EGR1/MAPK12/PLA2G4D/ADCY3/PLA2G4C/MMP14/CAMK2G/FSHB/ATF4/MAP2K1	58
KEGG	hsa04630	JAK-STAT signaling pathway	96/4078	162/8135	0.0115	0.04926	0.03431	STAM2/IL27RA/PIK3CA/SOCS7/IL2RG/MCL1/JAK1/MTOR/JAK2/LEP/PDGFB/MYC/PTPN6/AKT1/AKT2/IL22RA1/IL15/BCL2/SOS1/IL7R/IRF9/CCND1/IL20RA/PIK3R2/IFNGR1/IL23R/CSF3R/EPO/IFNG/GRB2/GH1/PIK3R1/IL13/SOCS4/CCND2/IL11RA/IL3RA/PIAS2/EP300/PIK3CB/JAK3/IL5/CTF1/IL2RB/SOCS1/HRAS/IFNW1/IL22RA2/IL24/STAT2/IL12RB1/IL6R/IFNA8/PRLR/IFNAR1/STAT1/IL11/SOCS6/PDGFRA/BCL2L1/TSLP/PIM1/STAT5A/SOCS5/SOS2/SOCS2/CSF2/EPOR/STAT6/LIFR/CSF3/IFNA16/IL12RB2/EGFR/PTPN2/PIAS1/PTPN11/FHL1/IL21R/STAM/IFNAR2/AOX1/IFNK/IL20/PDGFRB/SOCS3/AKT3/CCND3/IFNB1/CDKN1A/IL20RB/CNTF/IL7/GH2/EGF/PDGFA	96
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	50/4078	79/8135	0.01229	0.05195	0.03618	PIK3CA/MAP2K2/JAK1/MTOR/JAK2/NRAS/PDGFB/GSK3B/PLCG1/AKT1/AKT2/ARAF/BCL2/SOS1/PIK3R2/KRAS/PRKCB/GRB2/PIK3R1/PIK3CB/BAD/HRAS/RPS6KB2/IL6R/BRAF/SRC/PDGFRA/HGF/BCL2L1/NF1/NRG1/SOS2/EIF4EBP1/BCL2L11/SHC3/EGFR/ERBB3/MAPK1/PRKCG/BAX/EIF4E/SHC1/PDGFRB/PDGFC/AKT3/FOXO3/GAB1/MAP2K1/EGF/PDGFA	50
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	65/4078	106/8135	0.01291	0.05388	0.03753	ARHGEF1/JUND/AKAP13/ARRB2/GNAI2/PDE4A/CREB1/ITPR3/SP1/CYP24A1/ATF2/MMP24/ARAF/HBEGF/BCL2/ITPR2/ADCY1/ARRB1/MEF2C/PRKCB/PRKACB/CREB3L2/RXRA/PRKACG/NACA/GNA11/PLCB3/SLC34A1/GNAS/KL/PRKACA/GNAI3/BRAF/RXRG/GNA13/RXRB/PLD2/PTHLH/SLC34A2/FOS/SLC9A3R1/ADCY9/PLCB1/GATA3/VDR/ARHGEF11/MEF2A/EGFR/PDE4B/CREB3/CASR/MAPK1/GNA12/EGR1/PRKCG/MMP17/ADCY3/CYP27B1/PTH1R/MMP14/LRP6/CDKN1A/TRPV5/ATF4/MAP2K1	65
KEGG	hsa04072	Phospholipase D signaling pathway	88/4078	148/8135	0.01344	0.05544	0.03861	PTK2B/LPAR6/PIK3CA/RRAS/FCER1G/DGKD/MAP2K2/PLA2G4A/MTOR/GRM3/NRAS/TSC1/PDGFB/CYTH4/PLCG1/AKT1/DGKG/AKT2/PIK3R5/SOS1/ADCY1/PIK3R2/KRAS/PIK3CG/GRB2/ARF1/DGKA/PIK3R1/PIK3CB/PLCB3/HRAS/GNAS/PIP5K1B/PIK3R6/RAPGEF3/CYTH1/GNA13/RALB/KITLG/GRM5/PLD2/AGPAT4/CXCR2/PDGFRA/PLA2G4F/CYTH3/GRM4/CYTH2/AVPR1B/RRAS2/SOS2/AGPAT3/RALA/DGKE/ADCY9/SHC3/PLCB1/CXCL8/AGT/EGFR/DNM3/ARF6/PTPN11/MRAS/AVP/DGKK/LPAR1/MAPK1/GNA12/PIP5K1C/PLA2G4D/ADCY3/PLA2G4C/SHC1/INSR/PDGFRB/PDGFC/AKT3/GRM8/CXCR1/RAPGEF4/GAB1/AVPR2/MAP2K1/EGF/GAB2/PDGFA/INS	88
KEGG	hsa04659	Th17 cell differentiation	66/4078	108/8135	0.01363	0.05552	0.03867	NFATC3/IL27RA/IL2RG/MAPK8/NFKB1/LAT/JAK1/MTOR/CD3G/NFKBIB/JAK2/PLCG1/RORC/TGFBR2/CD3E/IFNGR1/SMAD2/IL23R/HIF1A/NFATC1/PPP3CB/IFNG/CHUK/MAPK14/SMAD3/RXRA/PPP3R1/TGFBR1/EBI3/HLA-DRA/JAK3/CD4/IL2RB/IL12RB1/IKBKB/IL6R/RXRG/RXRB/JUN/STAT1/CD247/STAT5A/FOS/FOXP3/STAT6/HLA-DMB/IL17A/RARA/GATA3/NFATC2/PRKCQ/HLA-DOB/MAPK13/TGFB1/LCK/MAPK1/IL21R/MAPK12/CD3D/HSP90AA1/IL17F/HLA-DPB1/IL1RAP/TBX21/PPP3R2/IRF4	66
KEGG	hsa04720	Long-term potentiation	43/4078	67/8135	0.01398	0.05563	0.03875	MAP2K2/CALML4/NRAS/ITPR3/ARAF/ITPR2/ADCY1/KRAS/GRIN2C/PPP3CB/PRKCB/PRKACB/PPP1CB/PRKACG/PPP3R1/EP300/PPP1CA/PLCB3/RPS6KA3/HRAS/RPS6KA6/GRIN2B/PRKACA/CALML5/RAPGEF3/RAP1B/BRAF/CAMK2B/GRM5/CAMK2A/PPP1R1A/PLCB1/CACNA1C/CALM1/GRIN2D/GRIN2A/MAPK1/PRKCG/RPS6KA1/CAMK2G/PPP3R2/ATF4/MAP2K1	43
KEGG	hsa04935	Growth hormone synthesis, secretion and action	72/4078	119/8135	0.01412	0.05563	0.03875	MAP2K6/PIK3CA/MAP2K2/GNAI2/MAPK8/CREB1/SSTR1/MTOR/JAK2/NRAS/ITPR3/GSK3B/PLCG1/JUNB/AKT1/AKT2/ATF2/ITPR2/SOS1/ADCY1/PIK3R2/KRAS/PRKCB/PRKACB/CREB3L2/GRB2/SSTR3/MAPK14/PRKACG/GH1/PIK3R1/EP300/PIK3CB/GNA11/PLCB3/CACNA1S/SOCS1/HRAS/ADCY10/GNAS/IGFBP3/PRKACA/GNAI3/CRK/GHRH/POU1F1/GHSR/MAP2K4/STAT1/STAT5A/SOS2/FOS/SOCS2/ADCY9/SHC3/PLCB1/CACNA1C/GHRHR/MAPK13/CREB3/MAPK1/PRKCG/MAPK12/ADCY3/SHC1/SOCS3/AKT3/IRS4/BCAR1/ATF4/MAP2K1/GH2	72
KEGG	hsa03440	Homologous recombination	28/4078	41/8135	0.01416	0.05563	0.03875	RBBP8/XRCC2/BARD1/POLD4/RPA3/ATM/RAD51B/RPA1/RAD50/EME1/BRIP1/XRCC3/MUS81/SYCP3/RPA4/RAD51C/BRCA1/SSBP1/BRCA2/RPA2/NBN/TOP3B/TOPBP1/BRCC3/BABAM1/RAD54L/UIMC1/RAD51D	28
KEGG	hsa05417	Lipid and atherosclerosis	124/4078	215/8135	0.01475	0.0573	0.03991	ARHGEF1/NFATC3/TBK1/MAP2K6/LY96/PIK3CA/HSPA5/CASP3/MAP2K7/FAS/CASP1/CYCS/CDC42/SOD2/MAPK8/IRF3/NFKB1/JAK2/CALML4/NRAS/APOA1/DDIT3/CYP2A7/GSK3B/PLCG1/AKT1/POU2F2/TNF/PDPK1/AKT2/XBP1/BCL2/ICAM1/PIK3R2/KRAS/NOS3/TP53/TNFSF10/NFATC1/VAV3/PPP3CB/CD36/APOA4/IL18/CHUK/MAPK14/RXRA/PPP3R1/PIK3R1/HSPA4/MIB1/PIK3CB/PLCB3/TNFRSF10A/BAD/HRAS/IRF7/NOX1/APAF1/TLR4/HSPA6/CALML5/IKBKB/RAP1B/RXRG/CYP1A1/ROCK2/IFNA8/RXRB/SRC/MAP2K4/CAMK2B/VAV1/TANK/JUN/BID/CASP9/LBP/CAMK2A/ABCA1/BCL2L1/CYP2A6/LYN/TIRAP/FOS/PLCB1/CXCL8/IFNA16/VLDLR/CCL5/NFATC2/CYP2B6/TRAF6/IRAK1/CALM1/HSPA1L/EIF2S1/MYD88/HSPA2/CASP6/MAPK13/EIF2AK3/MAPK1/APOB/MAPK12/NFE2L2/CXCL1/BAX/HSPD1/HSP90AA1/FASLG/AGER/CAMK2G/AKT3/IFNB1/MAP3K7/MMP1/CD40LG/CYP2C9/OLR1/PPP3R2/ERN1/ATF4/TRAF3	124
KEGG	hsa05017	Spinocerebellar ataxia	85/4078	143/8135	0.01511	0.058	0.0404	PUM1/PSMA2/GTF2B/PIK3CA/ATXN1L/CYCS/PSMA4/MAPK8/PSMC6/MTOR/RB1CC1/ITPR3/TBPL1/OPA1/SP1/AKT1/CIC/AKT2/XBP1/ATXN2L/MCU/GRIN3B/PSMD14/PSMC4/ITPR2/PIK3R2/PSMD12/GRIN2C/PSMD9/PRKCB/SLC25A4/PSMB1/PIK3R1/PSMB6/RBPJL/PSMD2/PIK3CB/PLCB3/VDAC2/ATP2A3/SLC1A6/ULK2/BECN1/ATP2A1/GRIN2B/PSMD1/ATXN2/ATP2A2/PSMA5/DAB1/SLC25A6/PSMA7/PDYN/ATG13/KCNC3/PSMB2/PSMD11/PSMB5/PSMA3/PUM2/PSMB7/PLCB1/PSMD8/VLDLR/PSMD3/PPIF/RBPJ/ATG101/GRIN2D/GRIN2A/PSMC3/AFG3L2/PSMD6/PRKCG/VDAC1/PSMA8/SLC25A31/OMA1/AKT3/PSMD7/PSMA1/KCND3/PSMD4/ERN1/ATXN3	85
KEGG	hsa04141	Protein processing in endoplasmic reticulum	100/4078	171/8135	0.01643	0.06237	0.04344	SEC31A/VCP/UBXN2A/SAR1B/RBX1/UBQLN4/HSPA5/SEC24C/CAPN2/MAP2K7/SEC61B/MAPK8/BCAP31/DDOST/EDEM1/CAPN1/UBE2D4/ERLEC1/DDIT3/EIF2AK4/MAN1A1/DNAJA1/XBP1/RNF185/BCL2/OS9/DNAJC3/PPP1R15A/UBE4B/YOD1/STT3A/CALR/SEC31B/SEC61G/DERL2/DNAJA2/UBQLN1/UBQLN2/SEC62/TUSC3/DERL3/CRYAB/SSR2/TRAM1/BAG2/RPN2/HSPA6/SEL1L2/SEC23B/PLAA/BAK1/SEC61A1/UBE2J1/MAN1C1/UBXN8/HSPH1/RRBP1/SEL1L/FBXO6/SEC24D/SAR1A/LMAN2/CKAP4/UBXN1/DNAJC10/SIL1/STT3B/BAG1/UBQLN3/DNAJB1/MOGS/EIF2AK2/CASP12/PDIA4/HSPA1L/NGLY1/EIF2S1/DNAJB2/SEC13/HSPA2/EIF2AK3/NFE2L2/SKP1/RNF5/BAX/STUB1/HSP90AA1/UGGT1/SVIP/SEC63/SEC24A/NPLOC4/EDEM2/SEC24B/ERN1/MBTPS1/ATF4/ATXN3/UBE2J2/DNAJB11	100
KEGG	hsa04510	Focal adhesion	116/4078	201/8135	0.01749	0.06544	0.04558	PIK3CA/CAPN2/FLNB/CDC42/MAPK8/PARVG/BIRC2/MYL10/FLT4/PDGFB/GSK3B/ILK/AKT1/MYL7/PDPK1/ITGAV/AKT2/RAC2/MYL12A/BCL2/SOS1/DOCK1/CCND1/PIK3R2/FLNC/MYL12B/COL4A4/VAV3/PRKCB/TNXB/ACTB/ZYX/GRB2/PPP1R12A/COL6A1/PPP1CB/PGF/VCL/PIK3R1/LAMA4/CCND2/TNC/PIK3CB/PPP1CA/ITGA4/BAD/LAMA2/HRAS/ITGB4/TLN2/PXN/PIP5K1B/CAV3/CRK/ACTN4/RAP1B/BRAF/ROCK2/VEGFC/ITGB5/LAMC2/SRC/VAV1/ROCK1/JUN/PDGFRA/HGF/PPP1R12C/PAK2/LAMA1/ARHGAP5/MYLK3/THBS3/COL2A1/PARVB/ITGA5/SOS2/ITGA6/VWF/LAMB1/ELK1/SHC3/ITGA3/TNR/EGFR/LAMB2/ITGA8/IBSP/SPP1/COL4A3/XIAP/ITGA11/RAC3/MYLPF/BIRC3/MAPK1/PIP5K1C/COL9A2/DIAPH1/PRKCG/ARHGAP35/MYL2/FLT1/SHC1/PDGFRB/PDGFC/AKT3/CCND3/PPP1R12B/PARVA/ITGA10/BCAR1/MAP2K1/THBS2/EGF/PDGFA	116
KEGG	hsa04926	Relaxin signaling pathway	77/4078	129/8135	0.01763	0.06544	0.04558	ARRB2/PIK3CA/MAP2K7/MAP2K2/GNAI2/GNB4/GNG2/MAPK8/GNGT2/CREB1/NFKB1/GNG10/GNB1/NRAS/AKT1/AKT2/TGFBR2/ATF2/RXFP3/SOS1/ADCY1/PIK3R2/KRAS/ARRB1/SMAD2/GNB5/NOS3/COL4A4/PRKACB/MMP2/CREB3L2/GRB2/MAPK14/PRKACG/TGFBR1/PIK3R1/GNG5/GNB2/PIK3CB/PLCB3/GNB3/HRAS/GNA15/GNAS/RLN2/PRKACA/GNAI3/VEGFC/SRC/MAP2K4/JUN/PRKCZ/GNG4/SOS2/FOS/RXFP1/ADCY9/INSL5/SHC3/PLCB1/EDN1/EGFR/COL4A3/MAPK13/TGFB1/CREB3/MAPK1/MAPK12/ADCY3/SHC1/AKT3/MMP1/INSL3/EDNRB/ATF4/MAP2K1/GNGT1	77
KEGG	hsa03022	Basal transcription factors	30/4078	45/8135	0.01836	0.0674	0.04694	TAF3/GTF2B/CCNH/TAF7/TAF15/GTF2E1/TBPL1/TAF10/GTF2A2/GTF2H3/GTF2H5/TAF5L/MNAT1/TAF12/TAF11/TAF4/ERCC3/TAF13/GTF2E2/GTF2F2/TAF6L/GTF2A1L/TAF5/TAF1L/GTF2H1/TAF7L/TAF6/CDK7/TAF1/TAF2	30
KEGG	hsa04664	Fc epsilon RI signaling pathway	43/4078	68/8135	0.01983	0.072	0.05015	MAP2K6/PIK3CA/FCER1G/MAP2K7/MAP2K2/MAPK8/PLA2G4A/LAT/NRAS/PLCG1/AKT1/TNF/PDPK1/AKT2/RAC2/SOS1/PIK3R2/KRAS/VAV3/GRB2/MAPK14/PIK3R1/IL13/PIK3CB/IL5/HRAS/ALOX5/MAP2K4/VAV1/PLA2G4F/LYN/SOS2/CSF2/INPP5D/RAC3/MAPK13/MAPK1/MAPK12/PLA2G4D/PLA2G4C/AKT3/MAP2K1/GAB2	43
KEGG	hsa05020	Prion disease	154/4078	273/8135	0.02009	0.07216	0.05026	UQCRQ/PSMA2/NDUFB3/NDUFA4/COX7A2/SDHA/PIK3CA/HSPA5/COX7C/COX7B/CASP3/SDHC/CSNK2A2/COX7A2L/CYCS/NDUFS3/NDUFB2/PSMA4/MAPK8/PSMC6/CREB1/NDUFA6/UQCRC1/C1QA/UQCR11/NDUFA5/NDUFB6/UQCR10/COX5B/ITPR3/COX6C/DDIT3/GSK3B/NDUFS2/NDUFA1/TNF/ATF2/RAC2/TUBA4A/MCU/GRIN3B/COX1/PSMD14/PSMC4/ITPR2/NDUFV2/PIK3R2/NDUFA13/NDUFS4/PSMD12/GRIN2C/KIF5B/NDUFS7/PSMD9/COX6A1/C1QB/C1QC/TUBA8/PPP3CB/PRKACB/CREB3L2/SLC25A4/CSNK2A1/MAPK14/C5/PRKACG/UQCRB/PPP3R1/NDUFA2/PSMB1/PIK3R1/PSMB6/NDUFS1/PSMD2/PIK3CB/COX6A2/VDAC2/COX2/BAD/RYR3/CACNA1S/NDUFV1/C7/APAF1/HSPA6/TUBB1/GRIN2B/PRKACA/PSMD1/TUBB4B/CAV3/ATP6/NDUFAB1/PSMA5/SLC25A6/NDUFA4L2/COX7A1/PSMA7/CASP9/UQCRFS1/NDUFB5/TUBB2B/PSMB2/PSMD11/PSMB5/PSMA3/KIF5C/COX5A/NDUFS6/PSMB7/CACNA1C/PSMD8/PSMD3/CCL5/PPIF/NDUFB4/CASP12/HSPA1L/GRIN2D/PRKCD/GRIN2A/PSMC3/EIF2S1/TUBA1A/HSPA2/KLC2/MAPK13/PSMD6/CREB3/UQCRC2/EIF2AK3/MAPK1/NDUFB8/EGR1/MAPK12/VDAC1/COX8A/PSMA8/BAX/COX6B1/SOD1/NDUFC1/C8G/CACNA1B/SLC25A31/PSMD7/TUBB3/COX4I2/PSMA1/STIP1/NDUFA8/PPP3R2/PSMD4/ATF4	154
KEGG	hsa03420	Nucleotide excision repair	31/4078	47/8135	0.02057	0.07309	0.05091	POLE4/CCNH/RBX1/POLD4/ERCC5/RPA3/CUL4B/RPA1/ERCC8/LIG1/RFC2/GTF2H3/POLE2/GTF2H5/RPA4/POLE3/MNAT1/DDB1/RPA2/XPC/ERCC3/XPA/RFC4/RFC5/PCNA/RFC1/GTF2H1/ERCC6/CDK7/DDB2/CUL4A	31
KEGG	hsa05215	Prostate cancer	59/4078	97/8135	0.02154	0.07574	0.05276	PIK3CA/MAP2K2/CREB1/NFKB1/MTOR/NRAS/PDGFB/GSK3B/AKT1/TCF7L2/PDPK1/AKT2/ARAF/BCL2/SOS1/CCND1/PIK3R2/KRAS/TP53/CREB3L2/GRB2/CHUK/PIK3R1/E2F3/EP300/PIK3CB/BAD/HRAS/MDM2/FOXO1/IKBKB/BRAF/RB1/CASP9/PDGFRA/SOS2/CCNE2/CCNE1/TMPRSS2/EGFR/ETV5/AR/SRD5A2/SPINT1/CREB3/MAPK1/GSTP1/LEF1/HSP90AA1/PDGFRB/PDGFC/AKT3/CDKN1A/CDK2/ATF4/MAP2K1/EGF/PDGFA/INS	59
KEGG	hsa04360	Axon guidance	105/4078	182/8135	0.0232	0.08072	0.05622	SSH1/NFATC3/PIK3CA/RRAS/BMPR2/ABLIM1/CDC42/GNAI2/CFL1/PARD3/LRIG2/NRAS/GSK3B/NFATC4/PLCG1/ILK/NCK1/PDPK1/RAC2/MYL12A/NCK2/EPHA7/PLXNA4/ABLIM2/PIK3R2/WNT5A/SEMA3C/KRAS/SEMA3F/PLXNA1/MYL12B/SEMA6B/PPP3CB/EPHB3/SEMA7A/RND1/PPP3R1/PIK3R1/UNC5A/PIK3CB/SEMA4B/RASA1/HRAS/SEMA6D/EPHA5/EPHA6/UNC5D/GNAI3/SEMA3D/EFNA5/EFNB1/PARD6G/CXCR4/ABLIM3/ROCK2/PLXNB1/EFNB3/EFNA1/SRC/ABL1/CAMK2B/TRPC1/ROCK1/SHH/SSH2/PRKCZ/CAMK2A/ROBO2/RHOD/L1CAM/NTN3/PAK2/SLIT2/CDK5/TRPC4/EPHA2/SEMA4C/EFNA4/SEMA3G/SRGAP1/SEMA3E/NFATC2/SSH3/SEMA3B/PTPN11/RAC3/NTNG2/DPYSL5/MAPK1/EPHB6/EPHA8/UNC5B/UNC5C/CAMK2G/BMPR1B/SEMA6C/EPHB4/SRGAP3/LRRC4C/SMO/PARD6A/PLXNA3/PPP3R2/ROBO1/DCC	105
KEGG	hsa04668	TNF signaling pathway	67/4078	112/8135	0.02413	0.0831	0.05788	MAP2K6/DAB2IP/PIK3CA/PTGS2/CASP3/MAP2K7/FAS/MAPK8/CREB1/NFKB1/TNFRSF1B/BIRC2/JUNB/AKT1/TNF/AKT2/ATF2/IL15/ICAM1/PIK3R2/PGAM5/CCL20/RIPK1/CREB3L2/CHUK/MAPK14/CXCL10/TRAF5/PIK3R1/PIK3CB/CX3CL1/CXCL5/IKBKB/VEGFC/MAP2K4/JUN/CEBPB/ITCH/CXCL6/IL18R1/FOS/CSF2/BAG4/EDN1/CCL5/IRF1/LTA/MAPK13/BIRC3/CREB3/MAPK1/MAPK12/RPS6KA5/CXCL1/NOD2/SOCS3/MMP14/AKT3/IFNB1/MAP3K7/TRADD/TAB3/CASP10/ATF4/MAP2K1/FADD/TRAF3	67
KEGG	hsa04215	Apoptosis - multiple species	22/4078	32/8135	0.02569	0.08755	0.06098	BIRC7/CASP3/CYCS/MAPK8/BIRC2/PMAIP1/NGFR/BCL2/HTRA2/APAF1/BECN1/BAK1/BID/CASP9/BCL2L1/BIRC5/BCL2L11/XIAP/BIRC3/DIABLO/BAX/FADD	22
KEGG	hsa04934	Cushing syndrome	90/4078	155/8135	0.02763	0.09323	0.06494	ARMC5/MAP2K2/GNAI2/CREB1/CRHR1/ITPR3/WNT9A/GSK3B/SP1/TCF7L2/APC2/NCEH1/ATF2/ITPR2/CCND1/ADCY1/USP8/WNT5A/FH/WNT7B/WDR5B/DVL1/AIPL1/CRH/PRKACB/CREB3L2/WNT16/SCARB1/PRKACG/AIP/E2F3/GNA11/PLCB3/CDKN2C/CACNA1S/NR5A1/CACNA1I/GNAS/PRKACA/GNAI3/RAP1B/BRAF/RB1/CDKN2B/CAMK2B/CYP17A1/WNT10A/CAMK2A/WNT6/CDK6/WNT2/FZD6/MRAP/CACNA1G/ADCY9/WNT8A/KCNK3/PLCB1/CACNA1C/AXIN2/CCNE2/CCNE1/DVL2/AGT/EGFR/FZD10/FZD2/FZD7/CREB3/FZD5/MAPK1/NR4A1/CDKN2A/RBBP5/ADCY3/LEF1/KMT2D/MEN1/CAMK2G/WNT7A/CACNA1H/CDKN1A/AXIN1/KCNA4/CDK2/ATF4/MAP2K1/WNT10B/ORAI1/WNT2B	90
KEGG	hsa05142	Chagas disease	61/4078	102/8135	0.03068	0.1025	0.07137	PPP2CA/PIK3CA/PPP2R2A/FAS/PPP2R1A/GNAI2/MAPK8/NFKB1/C1QA/CD3G/AKT1/TNF/AKT2/TGFBR2/CD3E/ADCY1/PIK3R2/IFNGR1/SMAD2/C1QB/C1QC/IFNG/CALR/CHUK/MAPK14/TGFBR1/PIK3R1/PIK3CB/GNA11/PLCB3/GNA15/KNG1/TLR4/GNAS/GNAI3/SERPINE1/IKBKB/MAP2K4/JUN/CD247/FOS/PLCB1/CXCL8/CCL5/PPP2R2C/TRAF6/IRAK1/GNA14/MYD88/MAPK13/TGFB1/MAPK1/ACE/MAPK12/PPP2R2D/CD3D/FASLG/AKT3/IFNB1/PPP2CB/FADD	61
KEGG	hsa00510	N-Glycan biosynthesis	32/4078	50/8135	0.03338	0.1104	0.07689	ALG6/MGAT5/ALG14/DDOST/ALG10/ALG5/MAN1A1/ALG12/MGAT3/DPM1/ST6GAL1/B4GALT2/STT3A/MGAT1/DOLPP1/DPAGT1/TUSC3/ALG13/ALG3/RPN2/ST6GAL2/MAN1C1/MAN2A1/FUT8/DPM3/STT3B/MOGS/MGAT4B/MGAT4C/DPM2/DOLK/MAN2A2	32
KEGG	hsa04658	Th1 and Th2 cell differentiation	55/4078	92/8135	0.03912	0.1247	0.08687	NFATC3/IL2RG/MAPK8/NFKB1/LAT/JAK1/CD3G/NFKBIB/JAK2/PLCG1/CD3E/RUNX3/IFNGR1/NFATC1/MAML1/PPP3CB/IFNG/CHUK/MAPK14/PPP3R1/IL13/HLA-DRA/RBPJL/JAK3/CD4/IL5/MAML2/IL2RB/IL12RB1/DLL3/IKBKB/JUN/STAT1/MAML3/CD247/STAT5A/FOS/MAF/STAT6/HLA-DMB/IL12RB2/GATA3/NFATC2/RBPJ/PRKCQ/HLA-DOB/MAPK13/LCK/MAPK1/MAPK12/CD3D/HLA-DPB1/TBX21/NOTCH3/PPP3R2	55
KEGG	hsa00430	Taurine and hypotaurine metabolism	12/4078	16/8135	0.03913	0.1247	0.08687	GADL1/CSAD/GGT7/GGT1/FMO4/FMO2/BAAT/FMO3/FMO5/ADO/GAD1/GGT6	12
KEGG	hsa04014	Ras signaling pathway	130/4078	232/8135	0.03921	0.1247	0.08687	RASAL3/TBK1/PIK3CA/RRAS/MAP2K2/CDC42/GNB4/GNG2/MAPK8/PLA2G4A/GNGT2/RAB5C/NFKB1/GNG10/GNB1/LAT/CALML4/NRAS/FLT4/PDGFB/SHOC2/PLCG1/AKT1/AKT2/RAC2/NGFR/SOS1/PIK3R2/KRAS/GNB5/PLA2G2A/RGL1/PRKCB/PRKACB/GRB2/PGF/CHUK/PRKACG/PIK3R1/RASA2/RASGRP4/GNG5/GNB2/RASSF1/PIK3CB/RASA1/BAD/BRAP/GNB3/HRAS/RASGRP2/FLT3LG/ETS1/GRIN2B/PRKACA/CALML5/EFNA5/IKBKB/RAP1B/RASSF5/VEGFC/EFNA1/FGF17/ABL1/RALB/KITLG/PLD2/FGF9/GNG4/PDGFRA/HGF/PLA2G4F/PAK2/BCL2L1/KSR1/NTF3/NF1/RRAS2/SOS2/EPHA2/RIN1/RALA/FGF16/EFNA4/FGF20/FGF21/ELK1/SHC3/FGF19/EGFR/RAB5B/PLA2G5/STK4/CALM1/ANGPT1/ARF6/GRIN2A/PTPN11/MRAS/PLA2G2D/RAC3/HTR7/KSR2/MAPK1/PLA2G2F/PRKCG/PLA2G4D/PLA2G4C/FGF8/FLT1/FASLG/SHC1/INSR/PDGFRB/PDGFC/AKT3/RASGRP1/FGF5/PLA2G12B/GAB1/TIAM1/PLA1A/MAP2K1/FGF18/GNGT1/EGF/PLCE1/GAB2/PDGFA/INS	130
KEGG	hsa04714	Thermogenesis	130/4078	232/8135	0.03921	0.1247	0.08687	SMARCA4/SMARCC1/UQCRQ/NDUFB3/NDUFA4/COX7A2/SDHA/COX14/COX7C/COX7B/COX20/CPT1C/SDHC/COX7A2L/NDUFS3/NDUFB2/SMARCD2/CREB1/NDUFA6/UQCRC1/COX16/UQCR11/NDUFA5/MTOR/NDUFB6/MLST8/UQCR10/NRAS/COX5B/TSC1/COX6C/COX15/NDUFS2/KDM1A/NDUFA1/ARID1B/ATF2/PRKAB1/COX1/SOS1/NDUFV2/NDUFAF5/NDUFAF1/ADCY1/KRAS/NDUFA13/NDUFS4/NDUFS7/COA1/COA6/COX6A1/COX17/NPPA/PRKACB/ACTB/CREB3L2/GRB2/PRKAG1/MAPK14/PRKACG/UQCRB/NDUFA2/CPT1A/NDUFS1/CPT2/COX6A2/RPS6KA3/COX2/SMARCD3/PRKAA2/SMARCC2/RPTOR/HRAS/ADCY10/NDUFV1/RPS6KA6/GNAS/PRKAA1/PRKACA/ATP6/BMP8B/RPS6KB2/NDUFAB1/ARID1A/ACSL3/NDUFA4L2/COX7A1/COA5/SMARCA2/UQCRFS1/COX19/NDUFB5/MGLL/PRKAG2/PPARGC1A/SOS2/AKT1S1/COX5A/NDUFS6/ADCY9/NDUFAF4/FGF21/SMARCD1/NDUFAF3/FRS2/ACTL6B/NDUFB4/COX11/COX18/PRKAB2/KLB/MAPK13/CREB3/UQCRC2/COX10/NDUFB8/MAPK12/COX8A/SMARCB1/ADCY3/COX6B1/PRDM16/RPS6KA1/NDUFC1/PRKAG3/ACSL5/SLC25A20/ACTL6A/COX4I2/NDUFA8	130
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	125/4078	223/8135	0.04202	0.1324	0.09222	UQCRQ/NDUFB3/NDUFA4/COX7A2/SDHA/PIK3CA/COX7C/COX7B/MAP2K7/MAP2K2/SDHC/COX7A2L/AKR1C3/NDUFS3/NDUFB2/SOD2/MAPK8/NDUFA6/NFKB1/UQCRC1/GSTO1/UQCR11/NDUFA5/NDUFB6/UQCR10/NRAS/COX5B/COX6C/NDUFS2/AKT1/NDUFA1/PDPK1/AKT2/COX1/ARAF/SOS1/NDUFV2/PIK3R2/KRAS/NDUFA13/NDUFS4/NDUFS7/CBR1/SLC26A9/HIF1A/COX6A1/SLC25A4/GRB2/HMOX1/CHUK/MAPK14/UQCRB/NDUFA2/PIK3R1/NDUFS1/ACP1/PIK3CB/AKR1A1/COX6A2/VDAC2/COX2/BAD/HRAS/NDUFV1/NOX1/GSTM1/ATP6/IKBKB/NDUFAB1/BRAF/CYP1A1/SRC/MAP2K4/SLC25A6/ABL1/NDUFA4L2/COX7A1/JUN/PLD2/PRKD3/UQCRFS1/HGF/NDUFB5/GSTA3/PTPRJ/SOS2/FOS/GSTM4/COX5A/NDUFS6/PPIF/EGFR/EPHX2/PRKD1/NDUFB4/PRKCD/PTPN11/MAPK13/UQCRC2/GSTM2/MAPK1/NDUFB8/MAPK12/VDAC1/MGST3/NFE2L2/KEAP1/COX8A/SLC26A1/PRKD2/COX6B1/SOD1/CYP1A2/NDUFC1/SLC25A31/AKT3/GSTO2/FOXO3/CYP1B1/NOX4/COX4I2/NDUFA8/GSTA1/MAP2K1/EGF	125
KEGG	hsa04152	AMPK signaling pathway	70/4078	120/8135	0.0426	0.133	0.09261	FASN/PPP2CA/PIK3CA/PPP2R2A/CPT1C/PPP2R1A/PFKM/CREB1/CAMKK2/MTOR/LEP/TSC1/PPP2R5E/AKT1/PDPK1/AKT2/PRKAB1/ACACB/CCND1/PIK3R2/CREB3L2/CD36/PRKAG1/ADIPOQ/PIK3R1/CPT1A/RAB8A/PIK3CB/MLYCD/PRKAA2/CAB39L/RPTOR/PRKAA1/PFKFB2/RPS6KB2/FOXO1/RAB11B/ELAVL1/CFTR/PPP2R5A/RAB10/CCNA2/SIRT1/PFKL/PPP2R5C/PRKAG2/PCK2/PPARGC1A/EIF4EBP1/AKT1S1/ADIPOR2/PPP2R2C/HMGCR/PRKAB2/CREB3/GYS2/FBP2/PPP2R2D/PRKAG3/HNF4A/INSR/AKT3/SCD/MAP3K7/IRS4/FOXO3/SREBF1/PPP2CB/ADRA1A/INS	70
KEGG	hsa05202	Transcriptional misregulation in cancer	109/4078	193/8135	0.0433	0.1334	0.09288	BMP2K/EWSR1/TAF15/HDAC1/BCL2A1/SPI1/NFKB1/BIRC2/GADD45A/AFF1/TFE3/ATM/DDIT3/DOT1L/NUPR1/MYC/SP1/TGFBR2/NGFR/GADD45B/FCGR1A/SS18L1/SUPT3H/CD86/CCNT2/MAX/MEF2C/TP53/MLF1/WNT16/SIN3A/RXRA/CCND2/MYCN/DUSP6/JMJD1C/SMAD1/CDKN2C/IL2RB/MDM2/BCL11B/ELANE/EYA1/IGFBP3/FLI1/DEFA5/NCOR1/BAK1/HOXA11/PAX5/BAIAP3/FOXO1/ZBTB17/RXRG/HHEX/CEBPA/PAX8/RXRB/CCNA2/MLLT1/CDK14/DEFA4/LYL1/NFKBIZ/GADD45G/TSPAN7/CEBPB/BCL2L1/LDB1/FUT8/TCF3/ASPSCR1/ETV6/MITF/SIX4/CSF2/ETV4/PML/KLF3/MEIS1/MAF/BCL6/CXCL8/RARA/ETV1/TMPRSS2/ETV5/LMO2/ETV7/KDM6A/TLX3/HDAC2/RUNX1T1/PROM1/ATF1/PAX3/SPINT1/BIRC3/DEFA6/BAX/GZMB/MEN1/FLT1/PAX7/MPO/CDKN1A/DDX5/DDB2/PDGFA	109
KEGG	hsa04066	HIF-1 signaling pathway	64/4078	109/8135	0.04352	0.1334	0.09288	PIK3CA/RBX1/TFRC/VHL/MAP2K2/PFKM/NFKB1/MTOR/PLCG1/AKT1/AKT2/BCL2/PIK3R2/IFNGR1/TF/LDHA/NOS3/HIF1A/HKDC1/NPPA/EPO/PRKCB/HK3/IFNG/HMOX1/PIK3R1/EP300/PIK3CB/LDHAL6A/ENO1/TLR4/SERPINE1/RPS6KB2/IL6R/CAMK2B/CAMK2A/PFKL/LDHAL6B/EGLN2/EIF4EBP1/LTBR/GAPDH/EDN1/PDHA2/EGFR/TIMP1/PGK1/ANGPT1/HK1/MAPK1/PRKCG/ALDOC/EIF4E/FLT1/INSR/CAMK2G/AKT3/CDKN1A/ENO3/PDHA1/MAP2K1/EGF/CUL2/INS	64
KEGG	hsa00010	Glycolysis / Gluconeogenesis	41/4078	67/8135	0.04453	0.1352	0.09418	DLD/PFKM/ALDH9A1/ALDH3A1/ALDH3A2/PKM/PGAM1/LDHA/TPI1/HKDC1/HK3/ADH1A/AKR1A1/LDHAL6A/ENO1/ADH5/ACSS2/ACSS1/BPGM/PFKL/LDHAL6B/GAPDHS/PCK2/ADH4/GAPDH/GCK/PGM1/ADPGK/ALDH2/MINPP1/PDHA2/PGK1/PGM2/HK1/FBP2/ALDOC/ALDH1B1/ALDH3B1/ENO3/PDHA1/ALDH3B2	41
KEGG	hsa04371	Apelin signaling pathway	80/4078	139/8135	0.04626	0.1386	0.09656	RRAS/MAP2K2/APLN/GNAI2/GNB4/GNG2/GNGT2/GNG10/GNB1/MTOR/CALML4/NRAS/ITPR3/AKT1/AKT2/PIK3R5/PRKAB1/ITPR2/CCND1/ADCY1/KRAS/SMAD2/GNB5/PIK3CG/NOS3/MEF2C/PRKACB/PRKAG1/SMAD3/PRKACG/TGFBR1/GNG5/GNB2/PLCB3/PRKAA2/RYR3/GNB3/HRAS/ADCY10/PRKAA1/BECN1/MAP1LC3A/PRKACA/GNAI3/CALML5/PIK3R6/SERPINE1/SLC8A1/RPS6KB2/MAP1LC3B/GNA13/GNG4/HDAC4/PRKAG2/MYLK3/PPARGC1A/RRAS2/ADCY9/HDAC5/PLCB1/MEF2A/SPP1/CALM1/PRKAB2/MRAS/MAP1LC3C/MAPK1/EGR1/CDH1/ADCY3/MYL2/MYL3/PRKAG3/AKT3/SLC8A2/PDE3B/NOTCH3/KLF2/MAP2K1/GNGT1	80
KEGG	hsa04725	Cholinergic synapse	66/4078	113/8135	0.04649	0.1386	0.09656	PIK3CA/GNAI2/GNB4/GNG2/GNGT2/CREB1/KCNJ4/GNG10/GNB1/CHRNB2/JAK2/NRAS/ITPR3/AKT1/AKT2/PIK3R5/BCL2/ITPR2/ADCY1/PIK3R2/KRAS/GNB5/PIK3CG/PRKCB/PRKACB/CREB3L2/KCNJ2/PRKACG/ACHE/PIK3R1/GNG5/GNB2/PIK3CB/GNA11/PLCB3/CACNA1S/GNB3/HRAS/PRKACA/GNAI3/PIK3R6/KCNJ3/KCNJ14/CAMK2B/CAMK2A/GNG4/KCNQ4/FOS/ADCY9/CHRNA4/PLCB1/CACNA1C/KCNQ5/KCNJ6/CREB3/MAPK1/PRKCG/ADCY3/CACNA1B/CAMK2G/AKT3/CHRNA6/KCNQ3/ATF4/MAP2K1/GNGT1	66
KEGG	hsa04625	C-type lectin receptor signaling pathway	61/4078	104/8135	0.0491	0.1451	0.1011	NFATC3/PIK3CA/CLEC4D/PTGS2/RRAS/FCER1G/CASP1/CLEC7A/MAPK8/NFKB1/CALML4/BCL10/NRAS/ITPR3/NFATC4/AKT1/TNF/AKT2/ITPR2/MALT1/IRF9/PIK3R2/KRAS/NFATC1/PPP3CB/CHUK/NFKB2/MAPK14/PPP3R1/MAPKAPK2/PIK3R1/PIK3CB/HRAS/MDM2/CLEC4M/CD209/CALML5/STAT2/LSP1/IKBKB/SRC/JUN/PLK3/STAT1/KSR1/RRAS2/CLEC4E/NFATC2/CCL22/CALM1/PRKCD/PTPN11/MRAS/IRF1/MAPK13/MAPK1/MAPK12/EGR2/AKT3/PPP3R2/CBLB	61
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	24/4078	37/8135	0.05067	0.1479	0.103	PIK3CA/SCNN1A/PDPK1/ATP1B1/PIK3R2/KRAS/PRKCB/PIK3R1/ATP1A1/FXYD4/PIK3CB/ATP1B3/SCNN1G/KCNJ1/MAPK1/PRKCG/SLC9A3R2/ATP1A2/SCNN1B/NR3C2/INSR/FXYD2/ATP1A4/INS	24
KEGG	hsa04071	Sphingolipid signaling pathway	69/4078	119/8135	0.05093	0.1479	0.103	PPP2CA/PIK3CA/PPP2R2A/FCER1G/MAP2K2/PPP2R1A/GNAI2/MAPK8/NFKB1/ADORA1/NRAS/PPP2R5E/AKT1/TNF/PDPK1/AKT2/RAC2/BCL2/CTSD/PIK3R2/KRAS/NOS3/S1PR2/TP53/PRKCB/MAPK14/SPTLC2/PIK3R1/PIK3CB/PLCB3/CERS6/HRAS/KNG1/GNAI3/GNA13/ROCK2/S1PR3/PPP2R5A/ROCK1/PRKCZ/PLD2/BID/PPP2R5C/PLCB1/PPP2R2C/CERS2/S1PR5/S1PR1/RAC3/MAPK13/SGMS1/MAPK1/GNA12/PRKCG/MAPK12/PPP2R2D/BAX/SPTLC1/AKT3/TRADD/OPRD1/CERS3/S1PR4/DEGS2/ASAH1/SGPP1/PPP2CB/MAP2K1/GAB2	69
KEGG	hsa05410	Hypertrophic cardiomyopathy	53/4078	90/8135	0.0585	0.1684	0.1173	CACNB2/DAG1/CACNA2D2/CACNG8/TNF/ITGAV/PRKAB1/TNNT2/ACTB/PRKAG1/CACNB1/PRKAA2/ITGA4/CACNA1S/LAMA2/ATP2A3/PRKAA1/ITGB4/ATP2A1/SGCD/SLC8A1/ATP2A2/ITGB5/TPM1/LMNA/PRKAG2/LAMA1/ITGA5/ITGA6/EMD/TTN/CACNA1C/EDN1/ITGA3/AGT/CACNG4/ITGA8/TPM4/PRKAB2/ITGA11/TGFB1/SGCA/ACE/MYL2/CACNB3/MYL3/PRKAG3/DES/CACNG2/SLC8A2/TPM2/ITGA10/CACNG5	53
KEGG	hsa03020	RNA polymerase	22/4078	34/8135	0.06216	0.1766	0.123	POLR2K/POLR1A/POLR3F/POLR1E/POLR2D/POLR2J2/CD3EAP/POLR2G/ZNRD1/POLR2E/TWISTNB/CRCP/POLR1B/POLR3D/POLR3H/POLR2C/POLR3G/POLR3A/POLR2J/POLR3K/POLR3GL/POLR1C	22
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	85/4078	150/8135	0.06237	0.1766	0.123	PPP2CA/PPP2R2A/CACNB2/PPP2R1A/GNAI2/CREB1/CREM/CALML4/PPP2R5E/CACNA2D2/CACNG8/AKT1/AKT2/ATP1B1/ATF2/PIK3R5/BCL2/ADCY1/PIK3CG/TNNT2/ATP2B3/PRKACB/CREB3L2/PPP1CB/MAPK14/PRKACG/ATP1A1/PPP1CA/PLCB3/CACNB1/CACNA1S/ATP2A3/GNAS/ATP2A1/PRKACA/GNAI3/CALML5/PIK3R6/SLC8A1/RAPGEF3/ATP2A2/TPM1/CAMK2B/PPP2R5A/CAMK2A/PPP2R5C/ADRA1D/ATP1B3/ATP2B4/PPP1R1A/ADCY9/PLCB1/CACNA1C/AGT/PPP2R2C/SCN1B/CACNG4/ATP2B1/CALM1/TPM4/MAPK13/CREB3/MAPK1/MAPK12/RPS6KA5/PPP2R2D/ADRB2/ADCY3/ATP1A2/MYL2/CACNB3/MYL3/CAMK2G/AKT3/FXYD2/CACNG2/SLC8A2/TPM2/RAPGEF4/CACNG5/ATP1A4/PPP2CB/ATF4/ADRA1A/ADRA1B	85
KEGG	hsa03030	DNA replication	23/4078	36/8135	0.06784	0.1883	0.1312	POLE4/POLD4/RPA3/RPA1/DNA2/LIG1/RFC2/POLE2/RPA4/POLE3/FEN1/SSBP1/RPA2/RNASEH2B/PRIM1/RNASEH1/PRIM2/RFC4/RFC5/PCNA/RFC1/MCM7/RNASEH2A	23
KEGG	hsa04260	Cardiac muscle contraction	51/4078	87/8135	0.06856	0.1883	0.1312	UQCRQ/COX7A2/COX7C/COX7B/CACNB2/COX7A2L/UQCRC1/UQCR11/UQCR10/COX5B/COX6C/CACNA2D2/CACNG8/ATP1B1/COX1/SLC9A6/COX6A1/TNNT2/UQCRB/ATP1A1/COX6A2/CACNB1/COX2/CACNA1S/ATP2A3/ATP2A1/SLC8A1/ATP2A2/TPM1/COX7A1/UQCRFS1/ASPH/ATP1B3/COX5A/CACNA1C/CACNG4/TPM4/UQCRC2/COX8A/COX6B1/ATP1A2/MYL2/CACNB3/MYL3/FXYD2/CACNG2/SLC8A2/TPM2/COX4I2/CACNG5/ATP1A4	51
KEGG	hsa04380	Osteoclast differentiation	73/4078	128/8135	0.06859	0.1883	0.1312	JUND/MAP2K6/PIK3CA/MAP2K7/LILRA6/FOSL2/MAPK8/SPI1/CREB1/NFKB1/JAK1/CALCR/JUNB/AKT1/TNF/AKT2/TGFBR2/LILRA1/FCGR1A/IRF9/PIK3R2/IFNGR1/FCGR2C/NFATC1/PPP3CB/IFNG/GRB2/CHUK/NFKB2/MAPK14/PPP3R1/TGFBR1/PIK3R1/PIK3CB/SOCS1/FCGR2B/NOX1/SIRPB1/STAT2/IKBKB/TYROBP/IFNAR1/JUN/STAT1/LILRA2/ACP5/TEC/MITF/FOS/NFATC2/TRAF6/TNFRSF11B/FCGR2A/MAPK13/TGFB1/LCK/MAPK1/CTSK/SQSTM1/MAPK12/IFNAR2/FHL2/SIRPG/SOCS3/AKT3/LILRA4/IFNB1/LILRB4/MAP3K7/PPP3R2/MAP2K1/FCGR3B/GAB2	73
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	58/4078	100/8135	0.06879	0.1883	0.1312	PIK3CA/CASP3/CDC42/MAPK8/NFKB1/JAK2/NRAS/PLCG1/AKT1/TNF/AKT2/TGFBR2/BCL2/CCND1/ICAM1/PIK3R2/KRAS/SMAD2/NOS3/COL4A4/NFATC1/PRKCB/MMP2/MAPK14/SMAD3/TGFBR1/PIK3R1/PIK3CB/PLCB3/HRAS/NOX1/SERPINE1/FOXO1/PLCD3/VEGFC/JUN/PRKCZ/STAT1/PIM1/STAT5A/PLCB1/EDN1/CXCL8/AGT/F3/COL4A3/PRKCD/MAPK13/TGFB1/MAPK1/EGR1/DIAPH1/MAPK12/BAX/AGER/AKT3/NOX4/PLCE1	58
KEGG	hsa04612	Antigen processing and presentation	46/4078	78/8135	0.07242	0.1941	0.1352	HSPA5/CREB1/B2M/TAPBP/TNF/HLA-G/NFYB/KIR2DS4/HLA-E/IFNG/CD74/CALR/HLA-B/KLRC3/HSPA4/HLA-DRA/CD4/KIR2DL3/HSPA6/CTSL/PSME3/KIR3DL3/HLA-C/CIITA/CD8A/KIR2DL2/HLA-A/PSME1/KIR2DS3/HLA-DMB/KIR2DL1/KIR2DS1/KIR2DS2/HSPA1L/HSPA2/HLA-DOB/HLA-F/KIR2DL4/NFYC/KIR2DS5/HSP90AA1/HLA-DPB1/TAP2/RFXANK/CTSS/KLRD1	46
KEGG	hsa04064	NF-kappa B signaling pathway	60/4078	104/8135	0.0728	0.1941	0.1352	ERC1/LY96/CARD11/PTGS2/CSNK2A2/BCL2A1/TNFSF13B/UBE2I/NFKB1/BIRC2/LAT/GADD45A/BCL10/PIDD1/ATM/PLCG1/TNF/PARP1/CCL13/BCL2/GADD45B/MALT1/ICAM1/CARD14/PRKCB/RIPK1/CSNK2A1/DDX58/CHUK/NFKB2/TRAF5/TLR4/EDA2R/IKBKB/LBP/GADD45G/BCL2L1/LYN/EDAR/TIRAP/LTBR/CCL21/CXCL8/TRAF6/IRAK1/PRKCQ/XIAP/MYD88/LTA/BIRC3/LCK/CCL19/CXCL1/MAP3K7/TRADD/CD40LG/TAB3/EDA/LTB/TRAF3	60
KEGG	hsa05203	Viral carcinogenesis	113/4078	204/8135	0.07319	0.1941	0.1352	YWHAE/SCRIB/GTF2B/HDAC10/CHD4/PIK3CA/CASP3/UBR4/HDAC1/CDC42/CREB1/IRF3/NFKB1/GTF2E1/USP7/JAK1/NRAS/POLB/KAT2A/TBPL1/YWHAB/ATF2/PMAIP1/HDAC7/PKM/IRF9/CCND1/PIK3R2/KRAS/HLA-G/KAT2B/HDAC3/YWHAG/TP53/HLA-E/PRKACB/CREB3L2/GRB2/HPN/CCR5/HLA-B/NFKB2/PRKACG/MAPKAPK2/TRAF5/PIK3R1/RASA2/CCND2/RBPJL/EP300/PIK3CB/JAK3/SND1/BAD/GSN/GTF2A2/GTF2H3/HRAS/MDM2/IRF7/HNRNPK/DDX3X/YWHAH/PXN/PRKACA/BAK1/ACTN4/RB1/SRC/CDKN2B/ATP6V0D1/HLA-C/CCNA2/JUN/RBL2/CDK6/HDAC4/HDAC6/STAT5A/HLA-A/LYN/DDB1/LTBR/CDK1/HDAC5/CCNE2/CCNE1/RBPJ/EIF2AK2/GTF2E2/HDAC11/HDAC2/YWHAZ/CREB3/HDAC8/MAPK1/GTF2A1L/HLA-F/DNAJA3/CDKN2A/SRF/BAX/ATP6V0D2/SCIN/EGR2/GTF2H1/CCND3/TRADD/CDKN1A/UBE3A/CDK2/ATF4/TRAF3	113
KEGG	hsa00514	Other types of O-glycan biosynthesis	29/4078	47/8135	0.07381	0.1941	0.1352	C1GALT1C1/MFNG/POMT2/ST6GAL1/C1GALT1/GXYLT1/B4GALT2/POMT1/PLOD3/GALNT10/LFNG/GXYLT2/GALNT9/ST6GAL2/POFUT1/OGT/GALNT3/GALNT6/GALNT13/GALNT1/COLGALT1/GALNTL6/GALNT14/GALNT11/GALNT15/GALNT8/RFNG/POFUT2/EOGT	29
KEGG	hsa00620	Pyruvate metabolism	29/4078	47/8135	0.07381	0.1941	0.1352	DLD/ALDH9A1/MDH1/ACACB/ALDH3A2/PKM/FH/LDHA/ADH1A/ACAT2/AKR1A1/LDHAL6A/ADH5/ACSS2/ACSS1/LDHAL6B/PCK2/ADH4/GLO1/ALDH2/PDHA2/GRHPR/LDHD/ME1/ACOT12/ALDH1B1/MDH2/ME2/PDHA1	29
KEGG	hsa04920	Adipocytokine signaling pathway	41/4078	69/8135	0.0762	0.1977	0.1377	CPT1C/MAPK8/CAMKK2/NFKB1/TNFRSF1B/MTOR/NFKBIB/JAK2/LEP/AKT1/TNF/AKT2/PRKAB1/ACACB/CD36/NPY/PRKAG1/ADIPOQ/CHUK/RXRA/CPT1A/PRKAA2/PRKAA1/IKBKB/RXRG/ACSL3/RXRB/PRKAG2/PCK2/PPARGC1A/ADIPOR2/PRKCQ/PRKAB2/PTPN11/PRKAG3/ACSL5/SOCS3/AKT3/ACSBG1/TRADD/IRS4	41
KEGG	hsa04915	Estrogen signaling pathway	78/4078	138/8135	0.07637	0.1977	0.1377	PIK3CA/MAP2K2/GNAI2/CREB1/NCOA2/CALML4/NRAS/ITPR3/KRT16/SP1/AKT1/AKT2/ATF2/HBEGF/BCL2/ITPR2/SOS1/ADCY1/CTSD/PIK3R2/KRAS/NCOA3/NOS3/PRKACB/MMP2/CREB3L2/GRB2/PRKACG/PIK3R1/PIK3CB/PLCB3/NCOA1/HRAS/HSPA6/ESR1/GNAS/PRKACA/GNAI3/CALML5/PGR/KCNJ3/SRC/KRT20/JUN/KCNJ5/KRT24/SOS2/FOS/ADCY9/SHC3/PLCB1/KRT19/RARA/KRT33B/EGFR/CALM1/HSPA1L/PRKCD/KCNJ6/OPRM1/HSPA2/CREB3/MAPK1/KRT36/KRT38/ADCY3/HSP90AA1/SHC1/AKT3/KRT9/KRT15/FKBP4/KRT13/TFF1/GABBR2/ATF4/KRT10/MAP2K1	78
KEGG	hsa04936	Alcoholic liver disease	80/4078	142/8135	0.07941	0.2037	0.1419	FASN/TBK1/MAP2K6/LY96/CASP3/MAP2K7/CPT1C/FAS/MAPK8/IRF3/CAMKK2/NFKB1/C1QA/ALDH9A1/GSK3B/AKT1/TCF7L2/TNF/AKT2/PRKAB1/ACACB/ALDH3A2/CCND1/C1QB/C1QC/C5AR1/RIPK1/PRKAG1/ADIPOQ/CHUK/MAPK14/C5/ADH1A/CPT1A/MLYCD/PRKAA2/ACADM/TLR4/PRKAA1/FOXO1/IKBKB/ADH5/IFNA8/MAP2K4/SIRT1/LBP/PRKAG2/PPARGC1A/TIRAP/ADH4/ADIPOR2/IL17A/LPIN2/CXCL8/IFNA16/ALDH2/TRAF6/IRAK1/PRKAB2/MYD88/MAPK13/MAPK12/CXCL1/LEF1/ALDH1B1/PRKAG3/FASLG/AKT3/SCD/IFNB1/MAP3K7/TRADD/FOXO3/NOX4/TAB3/SREBF1/ACOX1/FABP1/FADD/TRAF3	80
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	56/4078	97/8135	0.07991	0.2037	0.1419	PIK3CA/CDC42/WASF2/PLA2G4A/CFL1/ARPC1B/LAT/ARPC4/PLCG1/AKT1/AKT2/RAC2/FCGR1A/DOCK1/HCK/PIK3R2/ARPC2/VAV3/PRKCB/PIK3R1/PIK3CB/GSN/FCGR2B/ACTR3B/INPPL1/PIP5K1B/WASF1/CRK/RPS6KB2/ASAP3/ACTR3/VAV1/AMPH/PLD2/PLA2G4F/LYN/MARCKSL1/ARPC3/MARCKS/INPP5D/FCGR2A/PRKCD/ARF6/MAPK1/PIP5K1C/WASF3/PRKCG/PLA2G4D/SCIN/PLA2G4C/ARPC5L/AKT3/BIN1/MAP2K1/FCGR3B/GAB2	56
KEGG	hsa04150	mTOR signaling pathway	87/4078	156/8135	0.08974	0.2271	0.1581	ATP6V1G1/PIK3CA/ATP6V1E1/LAMTOR3/RICTOR/LAMTOR5/MAP2K2/ATP6V1C1/MTOR/MLST8/LAMTOR1/NRAS/TSC1/WNT9A/GSK3B/NPRL2/TELO2/AKT1/TNF/PDPK1/AKT2/SOS1/ATP6V1D/PIK3R2/WNT5A/KRAS/RRAGC/WNT7B/DVL1/LAMTOR4/PRKCB/GRB2/WNT16/CHUK/PIK3R1/PIK3CB/RPS6KA3/MIOS/PRKAA2/CAB39L/RPTOR/HRAS/RPS6KA6/ULK2/PRKAA1/RPS6KB2/IKBKB/DEPDC5/BRAF/WNT10A/ATP6V1B1/WNT6/SLC38A9/WNT2/FZD6/SOS2/EIF4EBP1/AKT1S1/WNT8A/RRAGA/LPIN2/DVL2/TBC1D7/PRR5/FZD10/ATP6V1H/FZD2/FZD7/SEC13/FLCN/RRAGB/FZD5/LAMTOR2/MAPK1/PRKCG/NPRL3/EIF4E/RPS6KA1/INSR/AKT3/WNT7A/LRP6/MAPKAP1/MAP2K1/WNT10B/WNT2B/INS	87
KEGG	hsa04657	IL-17 signaling pathway	54/4078	94/8135	0.09268	0.2328	0.1621	S100A8/JUND/TBK1/PTGS2/CASP3/S100A9/MAPK8/NFKB1/GSK3B/TRAF3IP2/TNF/IL17RE/IL25/MAPK6/CCL20/IFNG/CHUK/USP25/MAPK14/CXCL10/TRAF5/IL13/MUC5AC/S100A7A/IL5/ANAPC5/CXCL5/IKBKB/MAPK15/ELAVL1/JUN/CEBPB/CXCL6/SRSF1/FOS/CSF2/IL17A/CSF3/CXCL8/TRAF6/MAPK13/MAPK1/MAPK12/CXCL1/IL17B/HSP90AA1/IL17F/MUC5B/MAP3K7/TRADD/MMP1/TAB3/FADD/TRAF3	54
KEGG	hsa04930	Type II diabetes mellitus	28/4078	46/8135	0.09426	0.2335	0.1626	PIK3CA/MAPK8/MTOR/TNF/PKM/PIK3R2/HKDC1/HK3/ADIPOQ/PIK3R1/SOCS4/PIK3CB/SOCS1/IKBKB/PRKCZ/CACNA1G/SOCS2/GCK/CACNA1C/PRKCD/HK1/MAPK1/KCNJ11/CACNA1B/INSR/SOCS3/IRS4/INS	28
KEGG	hsa00650	Butanoate metabolism	18/4078	28/8135	0.09438	0.2335	0.1626	OXCT2/ECHS1/ACAT2/HMGCS1/HMGCL/ACADS/BDH1/ABAT/ACSM2B/HMGCLL1/ACSM2A/AACS/ACSM1/GAD1/ALDH5A1/BDH2/L2HGDH/HADHA	18
KEGG	hsa04142	Lysosome	74/4078	132/8135	0.09905	0.2433	0.1694	GGA1/CLTB/M6PR/ATP6V0A2/MAN2B1/NCOA7/AP1S1/GNPTG/AP1S2/GALC/CTSC/AP3S1/CTSF/ATP6V0B/LAPTM4A/CTSD/AP3M1/CLN5/ARSB/CLTC/AP1M1/FUCA2/SORT1/LAPTM5/GNS/HYAL4/GM2A/SCARB2/AP4M1/CTSL/CLTA/CTSW/ATP6V0D1/GUSB/CLN3/TCIRG1/NEU1/CD164/ACP5/SLC17A5/AP4S1/GGA3/NAGPA/DMXL1/CTSZ/AP1M2/GGA2/ATP6V0A1/PLA2G15/PSAPL1/LAPTM4B/CTSH/ATP6V1H/AP1G1/HEXA/GNPTAB/AP3B2/CTSK/PPT1/NPC2/NAPSA/ABCB9/ATP6V0D2/AP1G2/HYAL2/GLA/IGF2R/AP1B1/MFSD8/AP1S3/IDS/ASAH1/GALNS/CTSS	74
KEGG	hsa05110	Vibrio cholerae infection	30/4078	50/8135	0.1039	0.2516	0.1752	ATP6V1G1/ATP6V1E1/ATP6V0A2/SEC61B/ATP6V1C1/PLCG1/ATP6V0B/KDELR1/ATP6V1D/TJP1/PRKACB/ACTB/PRKACG/ARF1/SEC61G/GNAS/PRKACA/SEC61A1/CFTR/ATP6V0D1/TCIRG1/ATP6V1B1/ATP6V0E2/ADCY9/ATP6V0A1/SLC12A2/PDIA4/ATP6V1H/ADCY3/ATP6V0D2	30
KEGG	hsa04390	Hippo signaling pathway	87/4078	157/8135	0.1043	0.2516	0.1752	YWHAE/SCRIB/PPP2CA/PPP2R2A/BMPR2/PPP2R1A/TEAD2/PARD3/BIRC2/WNT9A/GSK3B/MYC/YWHAB/TCF7L2/APC2/TGFBR2/LIMD1/CCND1/MPP5/WNT5A/SMAD2/WNT7B/YWHAG/DVL1/WTIP/STK3/ACTB/WNT16/PRKCI/PPP1CB/SMAD3/TGFBR1/CCND2/RASSF1/PPP1CA/SMAD1/AFP/TEAD1/YAP1/DLG4/YWHAH/SERPINE1/BMP8B/PARD6G/LATS2/LLGL1/PRKCZ/WNT10A/WNT6/WNT2/FZD6/BIRC5/CSNK1D/SOX2/LLGL2/WNT8A/AXIN2/DVL2/NKD2/MOB1A/PPP2R2C/BMP5/FZD10/CTNNA2/NKD1/FZD2/FZD7/TP53BP2/YWHAZ/TGFB1/BIRC3/FZD5/CTNNA1/DLG2/PPP2R2D/BMPR1A/CDH1/LEF1/CCND3/WNT7A/BMPR1B/PARD6A/AXIN1/TEAD3/PPP2CB/WNT10B/WNT2B	87
KEGG	hsa04727	GABAergic synapse	51/4078	89/8135	0.1047	0.2516	0.1752	GNAI2/SLC38A1/GNB4/GNG2/GNGT2/GNG10/GNB1/GABRQ/HAP1/GABARAP/ADCY1/GNB5/PRKCB/PRKACB/GABRD/GABRB2/PRKACG/GNG5/GNB2/CACNA1S/GNB3/SLC38A2/GABARAPL2/PRKACA/GNAI3/SLC38A5/SRC/ABAT/SLC6A12/GNG4/GLS/ADCY9/CACNA1C/NSF/GAD1/SLC6A1/GABRB3/GABRG2/GABRR3/KCNJ6/PRKCG/ADCY3/CACNA1B/GABRB1/GABRA3/GABBR2/SLC32A1/GABARAPL1/PLCL1/GNGT1/GABRA4	51
KEGG	hsa05217	Basal cell carcinoma	37/4078	63/8135	0.1065	0.2535	0.1766	GADD45A/WNT9A/GSK3B/TCF7L2/APC2/GADD45B/WNT5A/WNT7B/TP53/DVL1/WNT16/KIF7/BAK1/SHH/WNT10A/WNT6/GADD45G/WNT2/FZD6/WNT8A/AXIN2/DVL2/FZD10/FZD2/FZD7/FZD5/BAX/LEF1/WNT7A/GLI3/CDKN1A/SMO/PTCH2/AXIN1/DDB2/WNT10B/WNT2B	37
KEGG	hsa05415	Diabetic cardiomyopathy	111/4078	203/8135	0.107	0.2535	0.1766	UQCRQ/NDUFB3/NDUFA4/COX7A2/SDHA/PIK3CA/MPC2/COX7C/COX7B/SDHC/COX7A2L/NDUFS3/NDUFB2/MAPK8/NDUFA6/NFKB1/UQCRC1/UQCR11/NDUFA5/MTOR/NDUFB6/CMA1/UQCR10/COX5B/COX6C/GSK3B/NDUFS2/SP1/AKT1/NDUFA1/AKT2/TGFBR2/RAC2/PARP1/COX1/NDUFV2/CTSD/PIK3R2/NDUFA13/NDUFS4/SMAD2/NDUFS7/NOS3/COX6A1/PRKCB/MMP2/CD36/SLC25A4/PPP1CB/MAPK14/SMAD3/UQCRB/NDUFA2/TGFBR1/PIK3R1/NDUFS1/PIK3CB/CPT2/PPP1CA/COX6A2/PLCB3/VDAC2/COX2/NDUFV1/ATP2A3/ATP2A1/ATP6/NDUFAB1/MPC1/ATP2A2/SLC25A6/PDK3/CAMK2B/NDUFA4L2/COX7A1/PRKCZ/PDK4/CAMK2A/G6PD/UQCRFS1/NDUFB5/GAPDH/COX5A/NDUFS6/PLCB1/AGT/PPIF/PDHA2/NDUFB4/PRKCD/MAPK13/TGFB1/UQCRC2/NDUFB8/ACE/GYS2/PRKCG/MAPK12/VDAC1/COX8A/COX6B1/NDUFC1/INSR/SLC25A31/AGER/CAMK2G/AKT3/COX4I2/NDUFA8/PDHA1/INS	111
KEGG	hsa04931	Insulin resistance	61/4078	108/8135	0.1088	0.255	0.1776	MLX/NR1H2/PIK3CA/MAPK8/CREB1/NFKB1/MTOR/GSK3B/MLXIP/AKT1/TNF/PDPK1/AKT2/PRKAB1/ACACB/PIK3R2/NOS3/NR1H3/PRKCB/CREB3L2/CD36/PRKAG1/PPP1CB/PPP1R3B/PIK3R1/CPT1A/PIK3CB/SLC27A5/PPP1CA/RPS6KA3/PRKAA2/RPS6KA6/PRKAA1/RPS6KB2/FOXO1/IKBKB/PPP1R3D/PRKCZ/PRKAG2/PCK2/PPARGC1A/SLC27A2/OGT/AGT/PRKCQ/PRKCD/PRKAB2/PTPN11/MLXIPL/PYGM/CREB3/TRIB3/GYS2/RPS6KA1/PRKAG3/INSR/SOCS3/AKT3/SLC27A3/SREBF1/INS	61
KEGG	hsa00640	Propanoate metabolism	20/4078	32/8135	0.1099	0.255	0.1776	DLD/ACACB/ALDH6A1/LDHA/ECHDC1/MCEE/ECHS1/MLYCD/LDHAL6A/ACADS/ACSS2/ACSS1/ABAT/LDHAL6B/HIBCH/BCKDHA/PCCA/HADHA/SUCLA2/ACOX1	20
KEGG	hsa04136	Autophagy - other	20/4078	32/8135	0.1099	0.255	0.1776	PPP2CA/IGBP1/ATG5/MTOR/MLST8/GABARAP/ATG3/ATG4A/ATG4D/ATG4C/RPTOR/ATG12/ULK2/GABARAPL2/BECN1/ATG13/ATG7/ATG101/PPP2CB/GABARAPL1	20
KEGG	hsa04713	Circadian entrainment	55/4078	97/8135	0.1149	0.2648	0.1844	GNAI2/GNB4/GNG2/GNGT2/CREB1/GNG10/GNB1/CALML4/ITPR3/ADCY1/GRIN2C/GNB5/PRKCB/PRKACB/PRKACG/GNG5/GNB2/PLCB3/RYR3/GNB3/ADCY10/CACNA1I/GNAS/GRIN2B/PRKACA/GNAI3/CALML5/ADCYAP1R1/KCNJ3/MTNR1B/ADCYAP1/CAMK2B/CAMK2A/GNG4/KCNJ5/FOS/CACNA1G/ADCY9/PLCB1/CACNA1C/CALM1/GRIN2D/GRIN2A/KCNJ6/MAPK1/GRIA4/PRKCG/RPS6KA5/ADCY3/CAMK2G/CACNA1H/MTNR1A/PER3/NOS1AP/GNGT1	55
KEGG	hsa05211	Renal cell carcinoma	40/4078	69/8135	0.1174	0.2686	0.1871	PIK3CA/RBX1/VHL/MAP2K2/CDC42/NRAS/PDGFB/TFE3/AKT1/AKT2/ARAF/SOS1/PIK3R2/KRAS/FH/HIF1A/GRB2/PIK3R1/EP300/PIK3CB/BAD/HRAS/ETS1/CRK/RAP1B/BRAF/JUN/HGF/PAK2/EGLN2/SOS2/PTPN11/FLCN/TGFB1/MAPK1/AKT3/CDKN1A/GAB1/MAP2K1/CUL2	40
KEGG	hsa03040	Spliceosome	81/4078	147/8135	0.1284	0.2918	0.2032	HNRNPC/PHF5A/CDC5L/SART1/SF3A1/PRPF18/SRSF5/PRPF19/SNRPE/SF3B1/SNRPG/SNRNP27/SF3A3/SF3B6/PRPF8/ZMAT2/RBM22/LSM7/SNRPD1/LSM3/THOC2/SNRPF/SYF2/CTNNBL1/LSM5/LSM8/SRSF3/DDX42/EIF4A3/HNRNPA3/SF3B2/SF3B3/DDX23/HNRNPM/SNRNP40/SF3B4/SLU7/SNRPD2/PRPF4/HNRNPU/ACIN1/AQR/SF3B5/U2SURP/HNRNPA1/CCDC12/HSPA6/HNRNPK/DHX16/PRPF40B/CDC40/DHX8/U2AF1L4/TXNL4A/LSM6/ALYREF/NCBP1/CRNKL1/PLRG1/SRSF1/PRPF6/SRSF7/MAGOHB/PUF60/BUD31/THOC1/SRSF4/SRSF10/HSPA1L/WBP11/RBM8A/PRPF31/PPIH/HSPA2/SRSF8/RBM25/NCBP2/ISY1/CHERP/DDX5/SNRNP70	81
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	29/4078	49/8135	0.1295	0.2923	0.2036	FPGT/PGM3/NAGK/NANP/RENBP/HKDC1/HK3/GNE/UXS1/PMM1/CYB5R4/GALE/GNPDA2/CYB5R3/GALT/MPI/GMPPA/UGDH/GCK/PGM1/GNPDA1/CYB5RL/PGM2/HEXA/HK1/GNPNAT1/UAP1/NPL/GALK2	29
KEGG	hsa01240	Biosynthesis of cofactors	84/4078	153/8135	0.1334	0.2972	0.207	PANK2/COQ2/GGCX/MTHFD2/DLD/MAT2B/KYNU/COQ5/PTS/NME7/KMO/RDH11/MOCS2/NADK/COX15/COQ3/AK2/OXSM/GGH/ALDH3A2/NMNAT3/BCAT2/AFMID/ALPI/EARS2/ALPL/GCLC/PMM1/MTHFD1/PPCDC/COASY/CAD/COQ7/MAT2A/IDO2/AKR1A1/UGT2B15/BCAT1/DHODH/NME3/MPI/AK9/UGT2B4/PPCS/GMPPA/HAAO/GUSB/AK6/NMNAT1/VKORC1L1/SHMT1/ASPDH/NME1/UGDH/FECH/UGT1A1/PHOSPHO2/NME6/PANK3/FLAD1/CMPK2/TPK1/ALDH2/NADK2/MOCS1/AK8/UGT1A6/MAT1A/RFK/LIAS/GCH1/LIPT1/UGT2A3/COX10/NFS1/DHRS3/ALDH1B1/FPGS/PANK1/UGT2B28/HPD/GSS/PNPO/AK7	84
KEGG	hsa00270	Cysteine and methionine metabolism	30/4078	51/8135	0.1344	0.2972	0.207	DNMT3A/MRI1/MAT2B/AHCYL1/DNMT1/APIP/GOT1L1/IL4I1/MDH1/BCAT2/LDHA/AMD1/GOT2/GCLC/MTR/MAT2A/BHMT2/LDHAL6A/BCAT1/SDS/PHGDH/LDHAL6B/GOT1/MAT1A/LACC1/MDH2/BHMT/GSS/AHCYL2/AGXT2	30
KEGG	hsa00330	Arginine and proline metabolism	30/4078	51/8135	0.1344	0.2972	0.207	GOT1L1/ALDH9A1/ALDH3A2/NOS3/AMD1/GOT2/PYCR1/SMOX/GAMT/P4HA1/ARG2/ODC1/HOGA1/SAT1/ALDH18A1/GOT1/AZIN2/PRODH2/ALDH2/CKMT2/CNDP2/LAP3/GATM/ALDH1B1/ALDH4A1/OAT/DAO/SAT2/ARG1/CKM	30
KEGG	hsa03450	Non-homologous end-joining	9/4078	13/8135	0.1353	0.2972	0.207	XRCC6/XRCC4/XRCC5/RAD50/DCLRE1C/FEN1/LIG4/DNTT/POLM	9
KEGG	hsa04925	Aldosterone synthesis and secretion	55/4078	98/8135	0.1373	0.2998	0.2088	CAMK1/CREB1/CALML4/ITPR3/ATP1B1/ATF2/CYP11B2/ITPR2/ADCY1/ATP2B3/NPPA/DAGLB/PRKCB/PRKACB/CREB3L2/SCARB1/PRKACG/ATP1A1/GNA11/PLCB3/CACNA1S/CACNA1I/GNAS/PRKACA/CALML5/CAMK2B/PRKD3/CAMK2A/KCNJ5/ATP1B3/CACNA1G/ATP2B4/ADCY9/KCNK3/PLCB1/CACNA1C/AGT/CAMK1D/PRKD1/ATP2B1/CALM1/ATF1/CREB3/NR4A1/PRKCG/PRKD2/ADCY3/ATP1A2/CAMK1G/CAMK2G/CACNA1H/ATP1A4/ATF4/ORAI1/DAGLA	55
KEGG	hsa00340	Histidine metabolism	14/4078	22/8135	0.1456	0.3123	0.2175	AMDHD1/ALDH9A1/HNMT/ALDH3A1/ALDH3A2/UROC1/ALDH2/HDC/CNDP2/HAL/ALDH1B1/ALDH3B1/ASPA/ALDH3B2	14
KEGG	hsa00900	Terpenoid backbone biosynthesis	14/4078	22/8135	0.1456	0.3123	0.2175	PCYOX1/IDI1/GGPS1/PDSS1/PDSS2/ACAT2/HMGCS1/MVK/ZMPSTE24/DHDDS/HMGCR/NUS1/ICMT/RCE1	14
KEGG	hsa04530	Tight junction	92/4078	169/8135	0.1458	0.3123	0.2175	SCRIB/MYL6/PPP2CA/PPP2R2A/MAP2K7/PPP2R1A/CDC42/MAPK8/ARPC1B/PARD3/ARPC4/TJAP1/TUBA4A/PRKAB1/MYL12A/CRB3/CCND1/MYH14/MPP5/ARPC2/ARHGEF18/TJP1/MYL12B/TUBA8/PRKACB/ACTB/PRKAG1/PRKCI/MYH11/PRKACG/MYH9/HSPA4/RAB8A/CLDN7/RAB8B/EZR/MARVELD3/HCLS1/RAP2C/PRKAA2/SYMPK/ACTR3B/MYL6B/MPP4/PRKAA1/PRKACA/ACTN4/PARD6G/ARHGEF2/NEDD4/CLDN2/ROCK2/MSN/ACTR3/SRC/CFTR/LLGL1/ROCK1/JUN/CD1A/PRKCZ/CLDN5/CLDN11/PRKAG2/LLGL2/SLC9A3R1/CLDN8/RDX/PPP2R2C/ARPC3/OCLN/PCNA/TUBA1A/PRKAB2/AMOTL2/CLDN10/DLG2/PPP2R2D/CLDN9/MYL2/PRKAG3/ARPC5L/CLDN16/TJP3/RAPGEF2/RAB13/CLDN18/PARD6A/TIAM1/CD1B/AMOTL1/PPP2CB	92
KEGG	hsa03013	Nucleocytoplasmic transport	60/4078	108/8135	0.1495	0.318	0.2215	POM121C/NUP50/NUP188/IPO9/NXT2/UBE2I/UPF1/AAAS/KPNA4/NMD3/NUP93/KPNA1/SENP2/TNPO2/THOC2/POM121/EIF4A3/NUP37/SUMO1/THOC7/SRRM1/SAP18/GLE1/KPNA6/ACIN1/EEF1A2/TNPO1/NUP210/RANGAP1/RAE1/RANBP2/ALYREF/TMEM33/NCBP1/IPO8/KPNA5/EEF1A1/KPNA2/IPO13/MAGOHB/CSE1L/THOC5/THOC1/DDX19A/RBM8A/KPNA3/SEC13/PNN/NUP214/NUP153/NUP35/RANBP17/IPO4/NCBP2/NXF3/UPF3A/NUP205/RNPS1/NUP210L/NUP98	60
KEGG	hsa05032	Morphine addiction	51/4078	91/8135	0.1516	0.3205	0.2232	ARRB2/GNAI2/PDE4A/GNB4/GNG2/GNGT2/GNG10/ADORA1/GNB1/GABRQ/ADCY1/ARRB1/GNB5/PRKCB/PRKACB/GABRD/GABRB2/PRKACG/PDE1A/GNG5/GNB2/GRK6/GNB3/GNAS/PRKACA/GNAI3/KCNJ3/GNG4/KCNJ5/PDE10A/ADCY9/PDE7A/PDE4B/GABRB3/GABRG2/GABRR3/KCNJ6/OPRM1/PDE1B/PRKCG/ADCY3/CACNA1B/PDE7B/GABRB1/GABRA3/PDE3B/GABBR2/SLC32A1/GRK5/GNGT1/GABRA4	51
KEGG	hsa04330	Notch signaling pathway	34/4078	59/8135	0.1526	0.3205	0.2232	APH1A/HDAC1/MFNG/ATXN1L/NUMBL/KAT2A/KAT2B/DVL1/MAML1/RBPJL/EP300/HEYL/MAML2/LFNG/NCSTN/HEY2/DTX3/DTX3L/DLL3/TLE4/MAML3/NOTCH4/PSENEN/TLE2/DVL2/RBPJ/APH1B/NCOR2/HDAC2/CTBP2/DTX1/RFNG/NOTCH3/HEY1	34
KEGG	hsa05145	Toxoplasmosis	62/4078	112/8135	0.1541	0.3216	0.224	BIRC7/MAP2K6/LY96/CASP3/CYCS/GNAI2/MAPK8/NFKB1/BIRC2/JAK1/NFKBIB/JAK2/AKT1/TNF/PDPK1/AKT2/PIK3R5/BCL2/IFNGR1/PIK3CG/IFNG/CCR5/CHUK/MAPK14/LAMA4/HLA-DRA/BAD/LAMA2/SOCS1/TLR4/HSPA6/GNAI3/PIK3R6/IKBKB/ALOX5/LAMC2/CIITA/STAT1/CASP9/BCL2L1/LAMA1/ITGA6/LAMB1/HLA-DMB/PPIF/TRAF6/LAMB2/IRAK1/HSPA1L/XIAP/MYD88/HSPA2/HLA-DOB/MAPK13/TGFB1/BIRC3/MAPK1/MAPK12/HLA-DPB1/AKT3/MAP3K7/CD40LG	62
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	114/4078	212/8135	0.1573	0.3262	0.2272	ARRB2/PIK3CA/MAP2K2/GNAI2/CREB1/NFKB1/KPNA4/GSTO1/MTOR/CHRNB2/JAK2/NRAS/KPNA1/MYC/AKT1/MIRLET7D/AKT2/ATF2/BCL2/SOS1/CCND1/ADCY1/PIK3R2/KRAS/ARRB1/AIPL1/PRKCB/PRKACB/CREB3L2/GRB2/PAQR7/RXRA/PRKACG/PIK3R1/AIP/PIK3CB/KPNA6/RPS6KA3/UGT2B15/BAD/CACNA1S/HRAS/RPS6KA6/KLF5/ESR1/GNAS/GSTM1/PRKACA/GNAI3/PGR/UGT2B4/RPS6KB2/DLL3/RXRG/CYP1A1/RB1/RXRB/SRC/FGF17/JUN/FGF9/KPNA5/BIRC5/STAT5A/GSTA3/SOS2/EIF4EBP1/FOS/KPNA2/GSTM4/CYP3A4/UGT1A1/FGF16/ADCY9/FGF20/CHRNA4/BCL6/CACNA1C/VDR/EGFR/CYP2B6/AR/EPHX2/UGT1A6/XIAP/KPNA3/CREB3/GSTM2/UGT2A3/MAPK1/PRKCG/MGST3/CHRNA9/ADRB2/ADCY3/CYP1A2/HSP90AA1/RPS6KA1/FGF8/CACNA1B/PAQR8/AKT3/CCND3/GSTO2/FGF5/UGT2B28/CYP1B1/GSTA1/ATF4/MAP2K1/FGF18/EGF/CDC6/NR1I3	114
KEGG	hsa04916	Melanogenesis	56/4078	101/8135	0.1648	0.3397	0.2366	MAP2K2/GNAI2/CREB1/CALML4/NRAS/WNT9A/GSK3B/TCF7L2/ADCY1/WNT5A/KRAS/WNT7B/DVL1/PRKCB/PRKACB/CREB3L2/WNT16/PRKACG/EP300/PLCB3/HRAS/GNAS/PRKACA/GNAI3/CALML5/CAMK2B/KITLG/WNT10A/CAMK2A/WNT6/WNT2/FZD6/MITF/ADCY9/WNT8A/PLCB1/EDN1/DVL2/MC1R/FZD10/CALM1/FZD2/FZD7/CREB3/FZD5/MAPK1/DCT/PRKCG/ADCY3/LEF1/CAMK2G/WNT7A/EDNRB/MAP2K1/WNT10B/WNT2B	56
KEGG	hsa00513	Various types of N-glycan biosynthesis	23/4078	39/8135	0.1719	0.3491	0.2431	ALG14/DDOST/MAN1A1/ALG12/B4GALT2/STT3A/MGAT1/TUSC3/ALG13/ALG3/RPN2/B4GALNT4/MAN1C1/MAN2A1/CHST8/FUT8/STT3B/B4GALNT3/CHST9/HEXA/MGAT4B/MGAT4C/MAN2A2	23
KEGG	hsa05152	Tuberculosis	97/4078	180/8135	0.1724	0.3491	0.2431	ATP6V0A2/CASP3/FCER1G/CYCS/CLEC7A/MAPK8/CREB1/RAB5C/MRC2/NFKB1/JAK1/JAK2/CALML4/BCL10/CEBPG/AKT1/ATP6V0B/TNF/RAB7A/AKT2/BCL2/FCGR1A/MALT1/CTSD/NFYB/IFNGR1/FCGR2C/PPP3CB/IFNG/CD74/IL18/MAPK14/PPP3R1/HLA-DRA/EP300/BAD/FCGR2B/APAF1/TLR4/CLEC4M/CD209/HSPA9/CALML5/RIPK2/LSP1/IFNA8/SRC/CAMK2B/ATP6V0D1/CIITA/PLK3/TCIRG1/STAT1/BID/CASP9/LBP/CAMK2A/CEBPB/KSR1/CAMP/TIRAP/CLEC4E/ATP6V0A1/HLA-DMB/IFNA16/VDR/TRAF6/RAB5B/IRAK1/FCGR2A/CALM1/ATP6V1H/EEA1/MYD88/HLA-DOB/MAPK13/TGFB1/MAPK1/MAPK12/NFYC/BAX/NOD2/CYP27B1/HSPD1/ATP6V0D2/HLA-DPB1/CAMK2G/AKT3/IFNB1/MRC1/TRADD/CASP10/RFXANK/PPP3R2/CTSS/FCGR3B/FADD	97
KEGG	hsa05016	Huntington disease	162/4078	306/8135	0.1724	0.3491	0.2431	UQCRQ/CLTB/PSMA2/NDUFB3/NDUFA4/COX7A2/SDHA/ACTR10/COX7C/COX7B/CASP3/MAP2K7/POLR2K/HDAC1/SDHC/COX7A2L/CYCS/NDUFS3/NDUFB2/SOD2/PSMA4/MAPK8/PSMC6/CREB1/NDUFA6/DCTN4/UQCRC1/UQCR11/NDUFA5/MTOR/NDUFB6/HAP1/UQCR10/DCTN6/COX5B/RB1CC1/TBPL1/COX6C/AP2M1/NDUFS2/SP1/NDUFA1/AP2B1/TUBA4A/POLR2D/COX1/PSMD14/PSMC4/NDUFV2/GPX2/NDUFA13/NDUFS4/PSMD12/KIF5B/NDUFS7/POLR2J2/AP2S1/PSMD9/TP53/COX6A1/GPX3/TUBA8/DNAH9/CREB3L2/SLC25A4/RCOR1/POLR2G/SIN3A/UQCRB/NDUFA2/PSMB1/POLR2E/DNAL4/PSMB6/CLTC/DCTN5/NDUFS1/EP300/PSMD2/COX6A2/PLCB3/VDAC2/COX2/AP2A2/NDUFV1/APAF1/ULK2/DLG4/BECN1/KCNJ10/TUBB1/GRIN2B/PSMD1/TUBB4B/ATP6/HTT/DNAH5/NDUFAB1/PSMA5/CLTA/SLC25A6/NDUFA4L2/COX7A1/GRM5/PSMA7/POLR2C/CASP9/DNAH1/UQCRFS1/NDUFB5/TUBB2B/ATG13/DNAH7/PPARGC1A/PSMB2/PSMD11/PSMB5/PSMA3/DNAH2/POLR2J/KIF5C/COX5A/NDUFS6/TAF4/PSMB7/PLCB1/PSMD8/PSMD3/PPIF/ATG101/NDUFB4/PSMC3/TUBA1A/HDAC2/KLC2/AP2A1/PSMD6/CREB3/UQCRC2/GRIA4/NDUFB8/VDAC1/COX8A/PSMA8/BAX/COX6B1/SOD1/NDUFC1/CACNA1B/SLC25A31/PSMD7/GPX5/GPX8/TUBB3/COX4I2/PSMA1/NDUFA8/REST/PSMD4/ERN1/SLC1A3/DCTN3	162
KEGG	hsa04728	Dopaminergic synapse	72/4078	132/8135	0.1748	0.3516	0.2449	PPP2CA/ARRB2/PPP2R2A/PPP2R1A/GNAI2/GNB4/GNG2/MAPK8/GNGT2/CREB1/GNG10/GNB1/CALML4/PPP2R5E/ITPR3/GSK3B/AKT1/AKT2/ATF2/ITPR2/ARRB1/KIF5B/GNB5/PPP3CB/PRKCB/PRKACB/CREB3L2/PPP1CB/MAPK14/PRKACG/GNG5/GNB2/CALY/PPP1CA/PLCB3/GNB3/GNAS/GRIN2B/PRKACA/GNAI3/CALML5/KCNJ3/DDC/CAMK2B/PPP2R5A/CAMK2A/GNG4/PPP2R5C/KCNJ5/FOS/DRD2/KIF5C/PLCB1/CACNA1C/PPP2R2C/CALM1/GRIN2A/KCNJ6/MAPK13/CREB3/GRIA4/ARNTL/PRKCG/MAPK12/PPP2R2D/CACNA1B/CAMK2G/AKT3/PPP2CB/ATF4/CLOCK/GNGT1	72
KEGG	hsa04520	Adherens junction	40/4078	71/8135	0.1758	0.3516	0.2449	CSNK2A2/CDC42/WASF2/NLK/PARD3/PTPN6/TCF7L2/TGFBR2/RAC2/WASL/LMO7/TJP1/SORBS1/ACTB/CSNK2A1/VCL/SMAD3/FER/IQGAP1/TGFBR1/EP300/ACP1/SSX2IP/WASF1/ACTN4/SRC/SNAI1/PTPRJ/YES1/EGFR/CTNNA2/PTPRB/RAC3/MAPK1/CTNNA1/WASF3/CDH1/LEF1/INSR/MAP3K7	40
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	12/4078	19/8135	0.1824	0.3604	0.251	GOT1L1/BCAT2/IDH3B/GOT2/GPT2/BCAT1/IDH3A/GOT1/ACY1/NAGS/GPT/IDH1	12
KEGG	hsa04310	Wnt signaling pathway	90/4078	167/8135	0.1829	0.3604	0.251	NFATC3/RBX1/CSNK2A2/NLK/MAPK8/WNT9A/GSK3B/NFATC4/SENP2/MYC/TCF7L2/MMP7/APC2/RAC2/CCND1/WNT5A/LGR5/WNT7B/TP53/DVL1/NFATC1/PPP3CB/SFRP4/PRKCB/PRKACB/CSNK2A1/WNT16/SMAD3/PRKACG/PPP3R1/CCND2/EP300/PLCB3/ZNRF3/SFRP5/PRKACA/WIF1/TLE4/ROCK2/CAMK2B/FRAT2/JUN/DKK2/WNT10A/CAMK2A/WNT6/TBL1XR1/PRICKLE2/WNT2/FZD6/CHD8/DKK4/NOTUM/TLE2/ROR2/WNT8A/RUVBL1/PLCB1/AXIN2/DVL2/NKD2/VANGL1/NFATC2/TBL1Y/RSPO3/FZD10/NKD1/FZD2/CXXC4/FZD7/FRZB/RAC3/FZD5/CTBP2/PRKCG/SKP1/GPC4/LEF1/CAMK2G/CCND3/WNT7A/RSPO1/LRP6/RSPO4/MAP3K7/PPARD/AXIN1/PPP3R2/WNT10B/WNT2B	90
KEGG	hsa00480	Glutathione metabolism	33/4078	58/8135	0.1834	0.3604	0.251	CHAC2/GSTO1/RRM2B/GGT7/GPX2/TXNDC12/GGT1/GPX3/PRDX6/GCLC/ODC1/GSTM1/RRM2/G6PD/GSTA3/GSTM4/PGD/GSTK1/OPLAH/LANCL1/LAP3/NAT8B/GGT6/GSTM2/GSTP1/MGST3/GSTO2/GPX5/GPX8/IDH1/ANPEP/GSTA1/GSS	33
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	54/4078	98/8135	0.1871	0.3654	0.2545	MAP2K6/PIK3CA/MAPK8/PLA2G4A/CALML4/ITPR3/PLCG1/ITPR2/ADCY1/TRPV4/PIK3R2/PRKCB/PRKACB/PPP1CB/TRPV2/MAPK14/PRKACG/ASIC4/PIK3R1/PIK3CB/PPP1CA/PLCB3/KNG1/GNAS/PRKACA/CALML5/PTGER4/SRC/TRPM8/CAMK2B/CAMK2A/PLA2G4F/ADCY9/PLCB1/F2RL1/ASIC1/PRKCH/PRKCQ/CALM1/PRKCD/BDKRB1/MAPK13/PRKCG/MAPK12/PLA2G4D/HTR2C/ADCY3/TRPV3/PLA2G4C/HTR2A/IL1RAP/CAMK2G/ALOX12/PTGER2	54
KEGG	hsa05418	Fluid shear stress and atherosclerosis	75/4078	139/8135	0.2048	0.3921	0.2731	TXN/MAP2K6/PIK3CA/DUSP1/MAP2K7/ACVR2A/BMPR2/MAPK8/NFKB1/GSTO1/TXN2/CALML4/PDGFB/AKT1/TNF/ITGAV/ASS1/AKT2/RAC2/BCL2/ICAM1/TRPV4/PIK3R2/NOS3/MEF2C/TP53/SUMO1/ACTB/IFNG/MMP2/HMOX1/CHUK/MAPK14/PIK3R1/PIK3CB/PRKAA2/NOX1/PRKAA1/GSTM1/CALML5/CAV3/CTSL/IKBKB/ARHGEF2/CDH5/SRC/MAP2K4/JUN/PRKCZ/GSTA3/FOS/GSTM4/EDN1/MEF2A/CALM1/RAC3/MAPK13/ACVR2B/GSTM2/GSTP1/SQSTM1/MAPK12/MGST3/NFE2L2/KEAP1/BMPR1A/HSP90AA1/SDC1/AKT3/GSTO2/MAP3K7/BMPR1B/GSTA1/KLF2/PDGFA	75
KEGG	hsa03430	Mismatch repair	14/4078	23/8135	0.2056	0.3921	0.2731	POLD4/RPA3/RPA1/LIG1/RFC2/MSH3/RPA4/MSH2/SSBP1/RPA2/RFC4/RFC5/PCNA/RFC1	14
KEGG	hsa04724	Glutamatergic synapse	62/4078	114/8135	0.2058	0.3921	0.2731	GNAI2/SLC38A1/GNB4/GNG2/PLA2G4A/GNGT2/GNG10/GNB1/GRM3/ITPR3/GRIN3B/ITPR2/ADCY1/GRIN2C/GNB5/PPP3CB/PRKCB/HOMER3/PRKACB/PRKACG/PPP3R1/GNG5/GNB2/PLCB3/GNB3/SLC38A2/SLC1A6/DLG4/GNAS/GRIN2B/PRKACA/GNAI3/KCNJ3/GRIK5/TRPC1/GRM5/PLD2/GNG4/PLA2G4F/SLC17A7/GRM4/GLS/ADCY9/SHANK1/PLCB1/CACNA1C/DLGAP1/GRIK4/GRIN2D/GRIN2A/SHANK2/MAPK1/GRIA4/PRKCG/PLA2G4D/ADCY3/PLA2G4C/GRM8/GRIK2/PPP3R2/SLC1A3/GNGT1	62
KEGG	hsa04622	RIG-I-like receptor signaling pathway	39/4078	70/8135	0.2066	0.3921	0.2731	TBK1/AZI2/PIN1/MAPK8/RNF125/ATG5/IRF3/NFKB1/IFIH1/NFKBIB/TNF/RIPK1/DDX58/CHUK/MAPK14/CXCL10/IFNW1/IRF7/ATG12/DDX3X/TBKBP1/IKBKB/IFNA8/TANK/OTUD5/ISG15/CXCL8/IFNA16/TRAF6/MAVS/MAPK13/MAPK12/IFNK/IFNB1/MAP3K7/TRADD/CASP10/FADD/TRAF3	39
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	39/4078	70/8135	0.2066	0.3921	0.2731	ATP6V1G1/ATP6V1E1/ATP6V0A2/CASP3/ATP6V1C1/CDC42/MAPK8/NFKB1/PLCG1/ATP6V0B/HBEGF/ATP6V1D/TJP1/CHUK/MAPK14/ADAM10/IKBKB/SRC/MAP2K4/ATP6V0D1/JUN/TCIRG1/CXCR2/ATP6V1B1/ATP6V0E2/LYN/NOD1/ATP6V0A1/CXCL8/CCL5/EGFR/ATP6V1H/PTPN11/MAPK13/MAPK12/CXCL1/ATP6V0D2/CXCR1/GIT1	39
KEGG	hsa05340	Primary immunodeficiency	22/4078	38/8135	0.2129	0.4018	0.2798	IL2RG/TNFRSF13B/CD3E/IL7R/CD79A/IGLL1/JAK3/CD4/DCLRE1C/ICOS/CIITA/RAG1/CD8A/AIRE/UNG/LCK/CD3D/AICDA/TAP2/CD40LG/RFXANK/ORAI1	22
KEGG	hsa04070	Phosphatidylinositol signaling system	53/4078	97/8135	0.2144	0.4023	0.2802	INPP4A/PIK3CA/DGKD/PI4KA/PPIP5K1/CALML4/ITPKA/ITPR3/IMPAD1/PLCG1/MTMR14/DGKG/IMPA1/ITPR2/PIK3R2/IP6K3/INPP5A/PIK3C2A/PRKCB/MTMR6/MTMR3/PIP4K2B/DGKA/PIK3R1/ITPKB/PIK3CB/MTM1/PLCB3/INPPL1/PIP5K1B/CALML5/PIP4K2C/PLCD3/IPMK/IP6K2/CDS2/PIK3C2B/MTMR1/DGKE/PIP4K2A/PLCB1/ITPK1/INPP5D/CALM1/DGKK/PIP5K1C/PRKCG/PPIP5K2/CDIPT/ITPKC/INPP1/IMPA2/PLCE1	53
KEGG	hsa04611	Platelet activation	67/4078	124/8135	0.2162	0.4033	0.2809	ARHGEF1/PIK3CA/FCER1G/GNAI2/GP6/PLA2G4A/ITPR3/AKT1/AKT2/PIK3R5/MYL12A/ITPR2/ADCY1/PIK3R2/PIK3CG/NOS3/MYL12B/PTGS1/PRKACB/ACTB/PPP1R12A/PRKCI/PPP1CB/MAPK14/PRKACG/PIK3R1/GP1BA/PIK3CB/PPP1CA/PLCB3/SNAP23/RASGRP2/GNAS/TLN2/PRKACA/GNAI3/PIK3R6/RAP1B/GNA13/ROCK2/VAMP8/SRC/FGB/TBXA2R/ROCK1/PRKCZ/PLA2G4F/MYLK3/LYN/VWF/ADCY9/F2RL3/PLCB1/GP5/FGG/FCGR2A/MAPK13/MAPK1/MAPK12/ARHGAP35/PLA2G4D/ADCY3/GP9/PLA2G4C/AKT3/RASGRP1/ORAI1	67
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	16/4078	27/8135	0.2247	0.4116	0.2867	ABO/GCNT2/FUT5/A4GALT/B4GALT2/FUT3/ST3GAL6/B3GNT3/B3GNT2/FUT2/FUT4/B3GALT5/FUT1/FUT6/B3GNT5/B4GALT4	16
KEGG	hsa00380	Tryptophan metabolism	24/4078	42/8135	0.2248	0.4116	0.2867	DLD/KYNU/KMO/IL4I1/ALDH9A1/ALDH3A2/AFMID/ASMT/ECHS1/ACAT2/IDO2/CYP1A1/HAAO/DDC/TPH1/ALDH2/ACMSD/AANAT/DLST/AOX1/CYP1A2/ALDH1B1/HADHA/CYP1B1	24
KEGG	hsa00190	Oxidative phosphorylation	72/4078	134/8135	0.2255	0.4116	0.2867	UQCRQ/NDUFB3/NDUFA4/COX7A2/SDHA/ATP6V1G1/ATP6V1E1/COX7C/COX7B/ATP6V0A2/SDHC/COX7A2L/ATP6V1C1/CYCS/NDUFS3/NDUFB2/NDUFA6/UQCRC1/UQCR11/NDUFA5/NDUFB6/UQCR10/COX5B/COX6C/COX15/NDUFS2/ATP6V0B/NDUFA1/ATP4A/COX1/ATP6V1D/NDUFV2/NDUFA13/NDUFS4/NDUFS7/COX6A1/COX17/UQCRB/NDUFA2/NDUFS1/COX6A2/COX2/NDUFV1/ATP6/NDUFAB1/PPA2/ATP6V0D1/NDUFA4L2/COX7A1/TCIRG1/ATP6V1B1/UQCRFS1/ATP6V0E2/NDUFB5/COX5A/NDUFS6/ATP6V0A1/NDUFB4/COX11/ATP6V1H/PPA1/UQCRC2/COX10/NDUFB8/COX8A/COX6B1/ATP6V0D2/NDUFC1/ATP4B/LHPP/COX4I2/NDUFA8	72
KEGG	hsa04270	Vascular smooth muscle contraction	72/4078	134/8135	0.2255	0.4116	0.2867	ARHGEF1/MYL6/MAP2K2/PLA2G4A/CALML4/ITPR3/ARAF/ITPR2/MYH14/ADCY1/PLA2G2A/NPPA/PRKCB/PRKACB/PPP1R12A/MYH11/PPP1CB/PRKACG/MYH9/KCNMB1/PPP1CA/GNA11/PLCB3/ADM2/CACNA1S/CALCRL/RAMP1/MYL6B/GNAS/PRKACA/CALML5/BRAF/GNA13/ROCK2/ROCK1/PLA2G4F/PPP1R12C/ADRA1D/MRVI1/AVPR1B/MYLK3/ADCY9/PLCB1/ADORA2B/CACNA1C/EDN1/AGT/ARHGEF11/PRKCH/PLA2G5/EDN2/PRKCQ/CALM1/PRKCD/PLA2G2D/AVP/MAPK1/GNA12/CALCA/PLA2G2F/PRKCG/PLA2G4D/ADCY3/ADM/PLA2G4C/PLA2G12B/PPP1R12B/NPR2/PPP1R14A/MAP2K1/ADRA1A/ADRA1B	72
KEGG	hsa00360	Phenylalanine metabolism	10/4078	16/8135	0.2302	0.4178	0.291	GOT1L1/IL4I1/ALDH3A1/GOT2/DDC/GOT1/AOC2/ALDH3B1/HPD/ALDH3B2	10
KEGG	hsa04015	Rap1 signaling pathway	111/4078	210/8135	0.2324	0.4196	0.2922	ITGAL/MAP2K6/PIK3CA/RRAS/MAP2K2/CDC42/GNAI2/PFN1/EVL/PARD3/LAT/CALML4/NRAS/FLT4/PDGFB/PLCG1/RGS14/AKT1/AKT2/RAC2/NGFR/ADCY1/PIK3R2/KRAS/VAV3/PRKCB/ACTB/PRKCI/PGF/MAPK14/PIK3R1/PFN4/KRIT1/PIK3CB/PLCB3/HRAS/RASGRP2/GNAS/TLN2/SKAP1/GRIN2B/GNAI3/CALML5/CRK/EFNA5/RAPGEF3/PARD6G/RAP1B/BRAF/RASSF5/VEGFC/EFNA1/SRC/FGF17/VAV1/RALB/KITLG/PRKCZ/PRKD3/FGF9/PDGFRA/HGF/MAGI3/EPHA2/DRD2/RALA/FGF16/ADCY9/EFNA4/FGF20/FGF21/F2RL3/PLCB1/ADORA2B/FGF19/EGFR/SIPA1L2/PRKD1/CALM1/MAGI2/ANGPT1/GRIN2A/MRAS/RAC3/MAPK13/LPAR1/MAPK1/SIPA1L3/PRKCG/MAPK12/PRKD2/CDH1/ADCY3/FGF8/FLT1/INSR/PDGFRB/PDGFC/AKT3/FGF5/RAPGEF2/RAPGEF4/PARD6A/TIAM1/BCAR1/MAP2K1/FGF18/EGF/PLCE1/PDGFA/INS	111
KEGG	hsa04540	Gap junction	48/4078	88/8135	0.2341	0.4203	0.2927	MAP2K2/GNAI2/NRAS/PDGFB/ITPR3/TUBA4A/ITPR2/SOS1/ADCY1/KRAS/TJP1/TUBA8/PRKCB/PRKACB/GRB2/PRKACG/GNA11/PLCB3/HRAS/GNAS/TUBB1/PRKACA/GNAI3/TUBB4B/SRC/GRM5/PDGFRA/TUBB2B/CSNK1D/SOS2/CDK1/DRD2/ADCY9/PLCB1/EGFR/TUBA1A/LPAR1/MAPK1/PRKCG/HTR2C/ADCY3/HTR2A/PDGFRB/PDGFC/TUBB3/MAP2K1/EGF/PDGFA	48
KEGG	hsa04710	Circadian rhythm	18/4078	31/8135	0.2406	0.4298	0.2993	RBX1/CRY2/CREB1/RORC/PRKAB1/PRKAG1/PRKAA2/PRKAA1/PRKAG2/CSNK1D/FBXL3/PRKAB2/ARNTL/SKP1/PRKAG3/PER3/BHLHE41/CLOCK	18
KEGG	hsa05171	Coronavirus disease - COVID-19	122/4078	232/8135	0.2443	0.4339	0.3022	RPL39/TBK1/RPL22L1/RPL35A/PIK3CA/RPL27A/FAU/RPL41/RPS7/RPL9/RPL26L1/CASP1/RPS17/RSL24D1/RPL18/RPS29/MAPK8/RPS9/RPL35/IRF3/NFKB1/RPL27/RPL34/IFIH1/C1QA/RPL7/JAK1/NFKBIB/RPL38/RPL30/RPLP2/PLCG1/RPS27L/TNF/RPS18/RPS10/HBEGF/RPL37A/IRF9/PIK3R2/RPL36A/C1QB/C1QC/PRKCB/C5AR1/DDX58/CHUK/RPS24/MAPK14/C5/CXCL10/PIK3R1/RPL11/RPL24/PIK3CB/C7/RPL6/TLR4/RPLP0/RPS21/STAT2/F13A1/IKBKB/UBA52/IL6R/ADAR/OAS1/IFNA8/FGB/C1S/IFNAR1/JUN/RPS11/MASP2/STAT1/OAS2/RPS15/CFB/RPS14/ISG15/RPL36/TLR7/FOS/VWF/CSF2/RPL37/CSF3/CXCL8/IFNA16/RPS3/TMPRSS2/EGFR/TRAF6/IRAK1/EIF2AK2/FGG/FCGR2A/MAVS/MYD88/RPL14/MX2/MAPK13/TLR3/MAPK1/ACE/PRKCG/MAPK12/IFNAR2/RPS27/C8G/RPS27A/RPS8/IFNB1/MAP3K7/RPL23A/MMP1/RPL32/RPS4X/OAS3/RPL19/ACE2/TRAF3	122
KEGG	hsa00564	Glycerophospholipid metabolism	53/4078	98/8135	0.2466	0.4349	0.3029	LPCAT4/DGKD/PLA2G4A/PLD3/ETNK1/DGKG/PTDSS2/PHOSPHO1/PCYT1A/PLA2G2A/CHKB/GPCPD1/MBOAT1/ADPRM/CRLS1/DGKA/ACHE/PNPLA6/CEPT1/LYPLA1/PGS1/PTDSS1/MBOAT2/PEMT/LPCAT2/LPCAT1/PLD2/AGPAT4/PLA2G4F/CDS2/PNPLA7/AGPAT3/DGKE/GPD1/LPIN2/ETNK2/PLA2G15/PLA2G5/PLA2G2D/CHPT1/DGKK/GPAM/GPD2/PLA2G2F/CDIPT/PLA2G4D/PCYT1B/PLA2G4C/LCLAT1/PLA2G12B/LPCAT3/TAZ/PLA1A	53
KEGG	hsa00562	Inositol phosphate metabolism	40/4078	73/8135	0.2474	0.4349	0.3029	INPP4A/PIK3CA/PI4KA/ITPKA/PLCG1/MTMR14/IMPA1/ALDH6A1/PIK3CG/TPI1/INPP5A/PIK3C2A/MTMR6/MTMR3/PIP4K2B/ITPKB/PIK3CB/PLCH2/MTM1/PLCB3/INPPL1/PIP5K1B/PIP4K2C/PLCD3/IPMK/PIP5KL1/PIK3C2B/MTMR1/PIP4K2A/PLCB1/MINPP1/ITPK1/INPP5D/PIP5K1C/CDIPT/ITPKC/INPP5J/INPP1/IMPA2/PLCE1	40
KEGG	hsa04114	Oocyte meiosis	70/4078	131/8135	0.25	0.4371	0.3044	YWHAE/ANAPC15/PPP2CA/RBX1/PPP2R1A/SPDYE2/CALML4/PPP2R5E/ITPR3/YWHAB/ANAPC10/ITPR2/ADCY1/ANAPC11/YWHAG/SLK/MAD2L2/PPP3CB/PRKACB/PPP1CB/MAPK14/PRKACG/PPP3R1/CDC27/PPP1CA/RPS6KA3/CCNB2/RPS6KA6/BUB1/ANAPC5/YWHAH/PRKACA/CALML5/PGR/SMC1A/MAD2L1/CDC25C/ANAPC2/PTTG1/CAMK2B/PPP2R5A/ANAPC13/CAMK2A/PPP2R5C/CDK1/ADCY9/FBXO5/CCNE2/CCNE1/AR/CDC26/CALM1/YWHAZ/MAPK13/MAPK1/MAPK12/SKP1/SMC1B/CCNB1/ADCY3/RPS6KA1/CAMK2G/CPEB1/PPP3R2/SMC3/AURKA/CDK2/PPP2CB/MAP2K1/INS	70
KEGG	hsa05100	Bacterial invasion of epithelial cells	42/4078	77/8135	0.2534	0.4402	0.3066	CLTB/PIK3CA/CDC42/WASF2/ARPC1B/ARPC4/ILK/WASL/DOCK1/PIK3R2/ARPC2/MAD2L2/ACTB/ELMO2/VCL/PIK3R1/CLTC/PIK3CB/CBL/HCLS1/RHOG/ACTR3B/ELMO1/PXN/CAV3/WASF1/CRK/ACTR3/SRC/CLTA/ITGA5/SHC3/ARPC3/DNM3/CTNNA2/CTNNA1/ELMO3/CDH1/SHC1/ARPC5L/GAB1/BCAR1	42
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/4078	20/8135	0.2552	0.4402	0.3066	CHST11/XYLT2/DSE/B3GALT6/CHPF/B3GAT3/CHPF2/CHST14/CSGALNACT2/B4GALT7/CHST13/CHST3	12
KEGG	hsa04151	PI3K-Akt signaling pathway	184/4078	354/8135	0.2557	0.4402	0.3066	YWHAE/LPAR6/PPP2CA/PIK3CA/PPP2R2A/MAP2K2/PPP2R1A/IL2RG/MCL1/GNB4/GNG2/GNGT2/CREB1/NFKB1/GNG10/GNB1/JAK1/MTOR/MLST8/JAK2/NRAS/TSC1/FLT4/PDGFB/PPP2R5E/GSK3B/MYC/YWHAB/AKT1/PDPK1/PKN2/ITGAV/AKT2/ATF2/PIK3R5/NGFR/BCL2/SOS1/PKN1/IL7R/CCND1/PIK3R2/KRAS/GNB5/PIK3CG/NOS3/CSF3R/YWHAG/COL4A4/TP53/EPO/PHLPP1/TNXB/CREB3L2/GRB2/COL6A1/PGF/CHUK/RXRA/GH1/PIK3R1/LAMA4/GNG5/GNB2/CCND2/TNC/IL3RA/PIK3AP1/PIK3CB/JAK3/PRKAA2/IL2RB/ITGA4/BAD/LAMA2/GNB3/RPTOR/HRAS/MDM2/FLT3LG/TLR4/PRKAA1/ITGB4/YWHAH/PIK3R6/EFNA5/RPS6KB2/BRCA1/IKBKB/IL6R/VEGFC/IFNA8/ITGB5/EFNA1/PRLR/LAMC2/FGF17/PPP2R5A/KITLG/IFNAR1/RBL2/FGF9/CASP9/THEM4/GNG4/PPP2R5C/PDGFRA/HGF/CDK6/BCL2L1/NTF3/LAMA1/PCK2/THBS3/COL2A1/ITGA5/SOS2/EIF4EBP1/ITGA6/EPHA2/VWF/LAMB1/EPOR/BCL2L11/FGF16/EFNA4/FGF20/MYB/FGF21/FGF19/CCNE2/CSF3/CCNE1/IFNA16/ITGA3/TNR/EGFR/PPP2R2C/LAMB2/ITGA8/IBSP/SPP1/ERBB3/COL4A3/MAGI2/ANGPT1/ITGA11/YWHAZ/CREB3/LPAR1/MAPK1/NR4A1/GYS2/COL9A2/IFNAR2/PPP2R2D/EIF4E/HSP90AA1/FGF8/FLT1/FASLG/CDC37/INSR/PDGFRB/PDGFC/AKT3/CCND3/IFNB1/FGF5/FOXO3/CDKN1A/IL7/ITGA10/CDK2/PPP2CB/ATF4/MAP2K1/FGF18/GH2/GNGT1/THBS2/EGF/PDGFA/INS	184
KEGG	hsa04024	cAMP signaling pathway	116/4078	221/8135	0.2601	0.4436	0.309	PIK3CA/RRAS/MAP2K2/GNAI2/PDE4A/MAPK8/CREB1/SSTR1/NFKB1/ADORA1/CALML4/CRHR1/HCN2/CGA/AKT1/AKT2/ATP1B1/RAC2/GRIN3B/ADCY1/PIK3R2/GRIN2C/ATP2B3/NPPA/NFATC1/CRH/VAV3/OXTR/PRKACB/CREB3L2/PPP1R12A/NPY/PPP1CB/HCN4/PRKACG/PIK3R1/ATP1A1/EP300/PIK3CB/PPP1CA/BAD/CACNA1S/ADCY10/SOX9/ATP2A3/GNAS/ATP2A1/GRIN2B/PRKACA/GNAI3/CALML5/ADCYAP1R1/GHSR/RAPGEF3/RAP1B/BRAF/ROCK2/ATP2A2/ADCYAP1/CFTR/CAMK2B/VAV1/ROCK1/HTR1A/JUN/PLD2/CAMK2A/PTGER3/RRAS2/HTR1E/PDE10A/ATP1B3/FOS/FSHR/DRD2/ATP2B4/ADCY9/CACNA1C/EDN1/TSHR/ATP2B1/GIP/EDN2/CALM1/PDE4B/GRIN2D/GRIN2A/HTR1F/RAC3/CREB3/MAPK1/GRIA4/ADRB2/ADCY3/ATP1A2/CAMK2G/AKT3/LHCGR/FXYD2/GLI3/GPHA2/HTR1D/RAPGEF4/PDE3B/TIAM1/GABBR2/HTR1B/FFAR2/FSHB/ATP1A4/ACOX1/HTR6/PTGER2/MAP2K1/PLCE1/ORAI1	116
KEGG	hsa01250	Biosynthesis of nucleotide sugars	21/4078	37/8135	0.2603	0.4436	0.309	FPGT/PGM3/NAGK/NANP/HKDC1/HK3/GNE/UXS1/PMM1/GALE/GALT/MPI/GMPPA/UGDH/GCK/PGM1/PGM2/HK1/GNPNAT1/UAP1/GALK2	21
KEGG	hsa04978	Mineral absorption	33/4078	60/8135	0.2653	0.4478	0.3119	ATP7A/SLC30A1/TRPV6/ATP1B1/MT1F/TF/SLC26A9/ATOX1/ATP2B3/HMOX1/ATP7B/ATP1A1/MT1E/SLC34A1/MT1X/SLC8A1/SLC26A3/MT1HL1/CYBRD1/SLC34A2/ATP1B3/MT1H/ATP2B4/VDR/MT2A/ATP2B1/ATP1A2/FXYD2/MT1G/SLC6A19/SLC8A2/CLCN2/ATP1A4	33
KEGG	hsa00220	Arginine biosynthesis	13/4078	22/8135	0.2654	0.4478	0.3119	GOT1L1/ASS1/NOS3/GOT2/GPT2/ARG2/CPS1/GOT1/GLS/ACY1/NAGS/GPT/ARG1	13
KEGG	hsa04977	Vitamin digestion and absorption	14/4078	24/8135	0.2746	0.4583	0.3192	CUBN/APOA1/LMBRD1/SLC5A6/SCARB1/APOA4/SLC52A3/SLC19A2/BTD/MMACHC/TCN2/SLC23A1/PNLIP/APOB	14
KEGG	hsa00071	Fatty acid degradation	24/4078	43/8135	0.2763	0.4583	0.3192	CPT1C/ALDH9A1/ALDH3A2/ECHS1/ADH1A/ACAT2/CPT1A/CPT2/ACADM/HADHB/ACADS/ECI2/ADH5/ACSL3/ACADSB/ADH4/ALDH2/ALDH1B1/ECI1/ACSL5/ACSBG1/HADHA/ACOX1/ACADL	24
KEGG	hsa04022	cGMP-PKG signaling pathway	88/4078	167/8135	0.2771	0.4583	0.3192	NFATC3/MAP2K2/GNAI2/CREB1/ADORA1/CALML4/ITPR3/NFATC4/AKT1/AKT2/ATP1B1/ATF2/PIK3R5/ITPR2/ADCY1/PIK3CG/NOS3/MEF2C/ATP2B3/NPPA/NFATC1/PPP3CB/CREB3L2/SLC25A4/PPP1R12A/PPP1CB/PPP3R1/RGS2/ATP1A1/KCNMB1/PPP1CA/GNA11/PLCB3/VDAC2/BAD/CACNA1S/ATP2A3/KNG1/ATP2A1/GNAI3/CALML5/PIK3R6/SLC8A1/GNA13/ROCK2/ATP2A2/SLC25A6/ROCK1/ADRA1D/MRVI1/MYLK3/ATP1B3/ATP2B4/ADCY9/PLCB1/CACNA1C/PPIF/NFATC2/MEF2A/ATP2B1/CALM1/CREB3/MAPK1/GNA12/VDAC1/ADRA2C/PDE5A/ADRB2/SRF/ADCY3/ATP1A2/INSR/SLC25A31/AKT3/FXYD2/SLC8A2/IRS4/OPRD1/EDNRB/PDE3B/NPR2/PPP3R2/ATP1A4/ATF4/MAP2K1/ADRA1A/ADRA1B/INS	88
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/4078	11/8135	0.2772	0.4583	0.3192	COQ2/GGCX/COQ5/COQ3/COQ7/VKORC1L1/HPD	7
KEGG	hsa03015	mRNA surveillance pathway	52/4078	97/8135	0.2786	0.4584	0.3193	PPP2CA/PABPC3/PPP2R2A/PPP2R1A/NXT2/ETF1/UPF1/HBS1L/TARDBP/PPP2R5E/DAZAP1/EIF4A3/WDR82/CPSF2/PPP1CB/SRRM1/FIP1L1/SAP18/GLE1/RNGTT/SMG7/PPP1CA/PAPOLG/ACIN1/CPSF4/SYMPK/GSPT1/MSI1/PABPC1/PABPC4L/PPP2R5A/CSTF2T/ALYREF/NCBP1/PPP2R5C/CPSF6/MAGOHB/NUDT21/PPP2R2C/DDX19A/RBM8A/PABPC5/PAPOLA/PNN/PPP2R2D/CPSF3/NCBP2/NXF3/UPF3A/RNPS1/SMG5/PPP2CB	52
KEGG	hsa05230	Central carbon metabolism in cancer	38/4078	70/8135	0.2816	0.4611	0.3212	PIK3CA/MAP2K2/PFKM/MTOR/NRAS/MYC/AKT1/AKT2/PKM/PGAM1/PIK3R2/KRAS/LDHA/HIF1A/TP53/HKDC1/HK3/PIK3R1/PIK3CB/LDHAL6A/HRAS/SCO2/PFKL/LDHAL6B/G6PD/PDGFRA/GLS/GCK/SLC1A5/PDHA2/EGFR/HK1/MAPK1/PDGFRB/AKT3/IDH1/PDHA1/MAP2K1	38
KEGG	hsa04922	Glucagon signaling pathway	57/4078	107/8135	0.2889	0.4707	0.3278	CPT1C/PFKM/PPP4C/CREB1/CALML4/ITPR3/AKT1/AKT2/ATF2/PRKAB1/ACACB/ITPR2/PKM/PGAM1/LDHA/PPP3CB/PRKACB/CREB3L2/PRKAG1/PRKACG/PPP3R1/CPT1A/EP300/PLCB3/LDHAL6A/PRKAA2/GNAS/PRKAA1/PRKACA/CALML5/FOXO1/CAMK2B/SIRT1/CAMK2A/PFKL/LDHAL6B/PRKAG2/PCK2/PPARGC1A/PRMT1/GCK/PLCB1/PDHA2/CALM1/SIK1/PRKAB2/PYGM/CREB3/GYS2/FBP2/PRKAG3/CAMK2G/AKT3/PDE3B/PDHA1/PPP3R2/ATF4	57
KEGG	hsa04723	Retrograde endocannabinoid signaling	78/4078	148/8135	0.2916	0.4728	0.3293	NDUFB3/NDUFA4/PTGS2/GNAI2/NDUFS3/GNB4/NDUFB2/GNG2/MAPK8/GNGT2/NDUFA6/GNG10/GNB1/NDUFA5/NDUFB6/GABRQ/ITPR3/NDUFS2/NDUFA1/ITPR2/NDUFV2/ADCY1/NDUFA13/NDUFS4/GNB5/NDUFS7/DAGLB/PRKCB/PRKACB/GABRD/MAPK14/GABRB2/PRKACG/NDUFA2/GNG5/GNB2/NDUFS1/PLCB3/CACNA1S/GNB3/NDUFV1/PRKACA/GNAI3/KCNJ3/NDUFAB1/NDUFA4L2/GRM5/GNG4/KCNJ5/SLC17A7/NDUFB5/MGLL/NDUFS6/ADCY9/PLCB1/CACNA1C/NDUFB4/GABRB3/GABRG2/GABRR3/KCNJ6/MAPK13/MAPK1/GRIA4/NDUFB8/PRKCG/MAPK12/ADCY3/NDUFC1/CACNA1B/ABHD6/GABRB1/GABRA3/NDUFA8/SLC32A1/GNGT1/DAGLA/GABRA4	78
KEGG	hsa01200	Carbon metabolism	61/4078	115/8135	0.2962	0.478	0.3329	SDHA/DLD/SDHC/PFKM/PRPS2/GOT1L1/MDH1/PKM/ALDH6A1/PGAM1/TKT/FH/GLYCTK/TPI1/HKDC1/HK3/IDH3B/MCEE/ECHS1/GOT2/GPT2/ACAT2/OGDH/ENO1/IDH3A/SDS/CPS1/ACADS/PHGDH/ADH5/ACSS2/ACSS1/PFKL/G6PD/SHMT1/GOT1/HIBCH/PRPS1/RPE/GAPDH/PGD/GCK/ADPGK/PDHA2/PGK1/DLST/PCCA/HK1/AMT/ME1/GPT/FBP2/RPIA/ALDOC/MDH2/IDH1/SUCLA2/ME2/ENO3/PDHA1/ACOX1	61
KEGG	hsa00730	Thiamine metabolism	9/4078	15/8135	0.307	0.493	0.3434	AK2/THTPA/ALPI/ALPL/ACP1/TPK1/AK8/NFS1/AK7	9
KEGG	hsa05414	Dilated cardiomyopathy	51/4078	96/8135	0.3129	0.497	0.3462	CACNB2/DAG1/CACNA2D2/CACNG8/TNF/ITGAV/ADCY1/TNNT2/PRKACB/ACTB/PRKACG/CACNB1/ITGA4/CACNA1S/LAMA2/ATP2A3/GNAS/ITGB4/ATP2A1/SGCD/PRKACA/SLC8A1/ATP2A2/ITGB5/TPM1/LMNA/LAMA1/ITGA5/ITGA6/EMD/ADCY9/TTN/CACNA1C/ITGA3/AGT/CACNG4/ITGA8/TPM4/ITGA11/TGFB1/SGCA/ADCY3/MYL2/CACNB3/MYL3/DES/CACNG2/SLC8A2/TPM2/ITGA10/CACNG5	51
KEGG	hsa03250	Viral life cycle - HIV-1	34/4078	63/8135	0.3139	0.497	0.3462	SUPT4H1/ELL2/PIN1/BICD2/KAT2A/CCNT2/KAT2B/CHMP6/CCR5/NELFCD/EP300/CD4/TSG101/ELL3/CXCR4/RANBP2/APOBEC3G/MLLT1/HGS/AFF4/CPSF6/SAMHD1/FURIN/MX2/NUP153/FEZ1/SMARCB1/VPS4B/BICD1/PPIA/VPS4A/TRIM5/MAP1A/SERINC5	34
KEGG	hsa00512	Mucin type O-glycan biosynthesis	20/4078	36/8135	0.314	0.497	0.3462	C1GALT1C1/ST6GALNAC3/C1GALT1/GALNT10/B3GNT3/ST3GAL1/GALNT9/B4GALT5/GALNT3/GALNT6/GALNT13/GALNT1/ST3GAL2/ST6GALNAC1/GALNTL6/GALNT14/GALNT11/GALNT15/GALNT8/GCNT1	20
KEGG	hsa04914	Progesterone-mediated oocyte maturation	54/4078	102/8135	0.3186	0.5019	0.3496	ANAPC15/PIK3CA/GNAI2/MAPK8/SPDYE2/AKT1/AKT2/CDC25B/ARAF/ANAPC10/ADCY1/PIK3R2/KRAS/ANAPC11/MAD2L2/KIF22/PRKACB/MAPK14/PRKACG/PIK3R1/PIK3CB/CDC27/RPS6KA3/CCNB2/RPS6KA6/BUB1/ANAPC5/PRKACA/GNAI3/PGR/MAD2L1/BRAF/CDC25C/ANAPC2/ANAPC13/CCNA2/CDK1/STK10/ADCY9/CDC26/MAPK13/MAPK1/MAPK12/CCNB1/ADCY3/HSP90AA1/RPS6KA1/AKT3/CPEB1/PDE3B/AURKA/CDK2/MAP2K1/INS	54
KEGG	hsa04620	Toll-like receptor signaling pathway	55/4078	104/8135	0.3204	0.5024	0.3499	TBK1/MAP2K6/LY96/PIK3CA/MAP2K7/MAP2K2/MAPK8/IRF3/NFKB1/AKT1/TNF/AKT2/CD86/PIK3R2/TLR5/RIPK1/CHUK/MAPK14/CXCL10/PIK3R1/PIK3CB/CXCL9/IRF7/TLR4/IKBKB/IFNA8/MAP2K4/IFNAR1/JUN/STAT1/LBP/IRF5/TIRAP/TLR7/FOS/TOLLIP/CXCL8/IFNA16/CCL5/TRAF6/IRAK1/SPP1/MYD88/MAPK13/TLR3/MAPK1/CTSK/MAPK12/IFNAR2/AKT3/IFNB1/MAP3K7/MAP2K1/FADD/TRAF3	55
KEGG	hsa04924	Renin secretion	37/4078	69/8135	0.3222	0.5029	0.3503	GNAI2/CREB1/ADORA1/CALML4/ITPR3/ITPR2/NPPA/PPP3CB/PRKACB/KCNJ2/PRKACG/PDE1A/PPP3R1/PLCB3/CACNA1S/GNAS/PRKACA/GNAI3/CALML5/ADCYAP1R1/PTGER4/ADCYAP1/PLCB1/CACNA1C/EDN1/AGT/EDN2/CALM1/PDE1B/ACE/ADRB2/CLCA2/PDE3B/PPP3R2/PTGER2/ORAI1/AQP1	37
KEGG	hsa01230	Biosynthesis of amino acids	40/4078	75/8135	0.3296	0.5096	0.355	MAT2B/PFKM/PRPS2/GOT1L1/ASS1/PKM/BCAT2/PGAM1/TKT/TPI1/IDH3B/GOT2/GPT2/MTR/MAT2A/PYCR1/ENO1/BCAT1/IDH3A/ARG2/SDS/CPS1/PHGDH/ALDH18A1/PFKL/SHMT1/GOT1/PRPS1/RPE/GAPDH/ACY1/NAGS/MAT1A/PGK1/GPT/RPIA/ALDOC/IDH1/ENO3/ARG1	40
KEGG	hsa04918	Thyroid hormone synthesis	40/4078	75/8135	0.3296	0.5096	0.355	HSPA5/CREB1/ITPR3/CGA/ATP1B1/ATF2/ITPR2/GPX2/ADCY1/GPX3/PRKCB/PRKACB/CREB3L2/PRKACG/ATP1A1/PLCB3/SLC26A4/GNAS/PRKACA/PAX8/TTF1/ATP1B3/ADCY9/PLCB1/DUOXA2/ASGR1/TSHR/TTR/PDIA4/CREB3/PRKCG/ADCY3/ATP1A2/SERPINA7/ALB/FXYD2/GPX5/GPX8/ATP1A4/ATF4	40
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	13/4078	23/8135	0.3432	0.5282	0.3679	MDH1/ATP1B1/ATP1A1/SLC4A4/GLS/PCK2/ATP1B3/ATP1A2/SLC25A10/FXYD2/CA2/ATP1A4/AQP1	13
KEGG	hsa04340	Hedgehog signaling pathway	30/4078	56/8135	0.3511	0.5355	0.373	MEGF8/ARRB2/GSK3B/GPR161/BCL2/CCND1/ARRB1/CUL3/PRKACB/PRKACG/EFCAB7/HHAT/CCND2/SPOPL/CSNK1G3/KIF7/KIF3A/SMURF2/PRKACA/SHH/SPOP/CSNK1D/CSNK1G2/CSNK1G1/SMURF1/DHH/GLI3/SMO/PTCH2/EVC2	30
KEGG	hsa04923	Regulation of lipolysis in adipocytes	30/4078	56/8135	0.3511	0.5355	0.373	PIK3CA/PTGS2/GNAI2/ADORA1/CGA/AKT1/AKT2/ADCY1/PIK3R2/PTGS1/NPPA/PRKACB/NPY/PRKACG/PIK3R1/PIK3CB/GNAS/PRKACA/GNAI3/MGLL/PTGER3/ADCY9/TSHR/ADRB2/ADCY3/INSR/AKT3/IRS4/PDE3B/INS	30
KEGG	hsa04730	Long-term depression	32/4078	60/8135	0.3564	0.5411	0.3769	PPP2CA/MAP2K2/PPP2R1A/GNAI2/PLA2G4A/NRAS/CRHR1/ITPR3/GNAZ/ARAF/ITPR2/KRAS/CRH/PRKCB/GNA11/PLCB3/HRAS/GNAS/GNAI3/BRAF/GNA13/PLA2G4F/LYN/PPP1R17/PLCB1/MAPK1/GNA12/PRKCG/PLA2G4D/PLA2G4C/PPP2CB/MAP2K1	32
KEGG	hsa03410	Base excision repair	18/4078	33/8135	0.3695	0.5585	0.389	POLE4/XRCC1/POLD4/POLB/PARP1/MUTYH/LIG1/POLE2/HMGB1/POLE3/FEN1/TDG/SMUG1/OGG1/UNG/PARP4/PCNA/PARP2	18
KEGG	hsa04971	Gastric acid secretion	40/4078	76/8135	0.3735	0.5619	0.3913	GNAI2/CALML4/ITPR3/ATP4A/ATP1B1/ITPR2/ADCY1/PRKCB/PRKACB/ACTB/KCNJ2/PRKACG/ATP1A1/EZR/PLCB3/KCNJ15/GNAS/KCNJ10/PRKACA/GNAI3/CALML5/CFTR/CAMK2B/CAMK2A/KCNK10/MYLK3/ATP1B3/ADCY9/PLCB1/CALM1/GAST/KCNJ1/PRKCG/ADCY3/ATP1A2/ATP4B/CAMK2G/CA2/KCNJ16/ATP1A4	40
KEGG	hsa00983	Drug metabolism - other enzymes	42/4078	80/8135	0.377	0.5623	0.3917	CDA/NAT1/UCK1/NME7/GSTO1/DPYD/CYP2A7/RRM2B/IMPDH2/UPP1/UGT2B15/TK1/NME3/GSTM1/UGT2B4/RRM2/TYMP/GUSB/UCKL1/NME1/CYP2A6/GSTA3/HPRT1/NAT2/GSTM4/CYP3A4/UGT1A1/NME6/UPB1/UGT1A6/GSTM2/UGT2A3/GSTP1/MGST3/GMPS/TPMT/TK2/GSTO2/MPO/UGT2B28/DPYS/GSTA1	42
KEGG	hsa05143	African trypanosomiasis	20/4078	37/8135	0.3771	0.5623	0.3917	FAS/APOA1/TNF/ICAM1/NPPA/PRKCB/IFNG/IL18/LAMA4/IDO2/PLCB3/KNG1/THOP1/PLCB1/F2RL1/MYD88/HPR/PRKCG/FASLG/APOL1	20
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	74/4078	143/8135	0.3798	0.5637	0.3926	PIK3CA/ACVR2A/MAP2K2/BMPR2/JAK1/JAK2/NRAS/SETDB1/PCGF1/PCGF5/WNT9A/GSK3B/MYC/AKT1/APC2/AKT2/TBX3/PCGF3/PIK3R2/WNT5A/KRAS/DUSP9/SMAD5/SMAD2/WNT7B/DVL1/HOXA1/GRB2/WNT16/MAPK14/SMAD3/PIK3R1/PIK3CB/JAK3/SMARCAD1/SMAD1/ONECUT1/OTX1/HRAS/WNT10A/WNT6/WNT2/FZD6/TCF3/SOX2/INHBE/MEIS1/WNT8A/AXIN2/LIFR/DVL2/NODAL/ACVR1C/FZD10/ESRRB/FZD2/FZD7/PCGF6/MAPK13/FZD5/ACVR2B/MAPK1/MAPK12/BMPR1A/AKT3/WNT7A/BMPR1B/SMAD9/ZFHX3/AXIN1/REST/MAP2K1/WNT10B/WNT2B	74
KEGG	hsa04512	ECM-receptor interaction	46/4078	88/8135	0.3833	0.5665	0.3945	DAG1/GP6/ITGAV/FRAS1/DSPP/COL4A4/TNXB/CD36/COL6A1/HMMR/LAMA4/TNC/GP1BA/ITGA4/LAMA2/ITGB4/NPNT/SV2C/ITGB5/LAMC2/SV2A/LAMA1/THBS3/COL2A1/ITGA5/ITGA6/VWF/LAMB1/DMP1/ITGA3/TNR/GP5/LAMB2/ITGA8/IBSP/SPP1/COL4A3/ITGA11/HSPG2/COL9A2/GP9/SDC1/AGRN/ITGA10/CD44/THBS2	46
KEGG	hsa04940	Type I diabetes mellitus	23/4078	43/8135	0.3866	0.5688	0.3962	PTPRN2/FAS/TNF/CD86/HLA-G/CD28/HLA-E/IFNG/HLA-B/HLA-DRA/HLA-C/HLA-A/HLA-DMB/GAD1/ICA1/HLA-DOB/LTA/HLA-F/HSPD1/GZMB/FASLG/HLA-DPB1/INS	23
KEGG	hsa05030	Cocaine addiction	26/4078	49/8135	0.3944	0.5775	0.4022	GNAI2/CREB1/NFKB1/GRM3/ATF2/GRIN3B/GRIN2C/PRKACB/CREB3L2/PRKACG/DLG4/GNAS/GRIN2B/PRKACA/GNAI3/CDK5R1/DDC/JUN/PDYN/GPSM1/CDK5/DRD2/GRIN2D/GRIN2A/CREB3/ATF4	26
KEGG	hsa04913	Ovarian steroidogenesis	27/4078	51/8135	0.3967	0.5775	0.4022	PTGS2/AKR1C3/PLA2G4A/CGA/HSD17B7/ADCY1/PRKACB/SCARB1/HSD17B2/PRKACG/GNAS/PRKACA/CYP1A1/ALOX5/CYP17A1/PLA2G4F/FSHR/ADCY9/PLA2G4D/ADCY3/PLA2G4C/INSR/LHCGR/HSD17B1/CYP1B1/FSHB/INS	27
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/4078	14/8135	0.399	0.5775	0.4022	B4GALT2/B3GNT2/ST3GAL1/FUT8/CHST2/ST3GAL2/B3GNT7/B4GALT4	8
KEGG	hsa04670	Leukocyte transendothelial migration	59/4078	114/8135	0.3994	0.5775	0.4022	ITGAL/PTK2B/PIK3CA/CDC42/GNAI2/MYL10/CD99/PLCG1/MYL7/RAC2/MYL12A/ICAM1/PIK3R2/MYL12B/VAV3/PRKCB/ACTB/MMP2/MAPK14/VCL/PIK3R1/PIK3CB/CLDN7/EZR/ITGA4/PXN/GNAI3/ACTN4/RAPGEF3/RAP1B/CXCR4/CDH5/CLDN2/RASSF5/ROCK2/MSN/CD99L2/VAV1/ROCK1/CLDN5/CLDN11/ARHGAP5/CLDN8/OCLN/CTNNA2/PTPN11/MYLPF/MAPK13/CLDN10/CTNNA1/PRKCG/MAPK12/ARHGAP35/CLDN9/MYL2/CLDN16/RAPGEF4/CLDN18/BCAR1	59
KEGG	hsa05134	Legionellosis	30/4078	57/8135	0.4029	0.58	0.404	VCP/SAR1B/CASP3/CASP1/CYCS/SEC22B/NFKB1/HBS1L/TNF/NLRC4/TLR5/IL18/NFKB2/ARF1/EEF1A2/APAF1/TLR4/HSPA6/CASP9/SAR1A/EEF1A1/CLK1/CXCL8/CLK4/HSPA1L/MYD88/HSPA2/CXCL1/HSPD1/RAB1A	30
KEGG	hsa00561	Glycerolipid metabolism	32/4078	61/8135	0.4066	0.5828	0.4059	DGKD/ALDH9A1/DGKG/ALDH3A2/GLYCTK/MBOAT1/DGKA/AKR1A1/LIPF/GK/PNPLA3/PNLIPRP2/MOGAT1/MBOAT2/AGPAT4/DGAT1/AKR1B10/MGLL/AGPAT3/DGKE/LPIN2/AKR1B1/ALDH2/PNLIP/DGKK/GPAM/ALDH1B1/GLA/MOGAT3/LCLAT1/PNLIPRP1/AGK	32
KEGG	hsa05321	Inflammatory bowel disease	34/4078	65/8135	0.4099	0.5851	0.4075	IL2RG/NFKB1/RORC/TNF/IFNGR1/SMAD2/IL23R/NFATC1/TLR5/IFNG/IL18/SMAD3/IL13/HLA-DRA/IL5/TLR4/IL12RB1/JUN/STAT1/IL18R1/FOXP3/MAF/STAT6/HLA-DMB/IL17A/IL12RB2/GATA3/HLA-DOB/TGFB1/IL21R/NOD2/IL17F/HLA-DPB1/TBX21	34
KEGG	hsa05031	Amphetamine addiction	36/4078	69/8135	0.413	0.5869	0.4088	HDAC1/CREB1/CALML4/ATF2/GRIN3B/GRIN2C/PPP3CB/PRKCB/PRKACB/CREB3L2/PPP1CB/PRKACG/PPP3R1/PPP1CA/GNAS/GRIN2B/PRKACA/CALML5/DDC/CAMK2B/JUN/PDYN/SIRT1/CAMK2A/FOS/CACNA1C/CALM1/GRIN2D/GRIN2A/HDAC2/CREB3/GRIA4/PRKCG/CAMK2G/PPP3R2/ATF4	36
KEGG	hsa03320	PPAR signaling pathway	39/4078	75/8135	0.4171	0.5885	0.4099	DBI/UBC/CPT1C/ANGPTL4/APOA1/ILK/PDPK1/FABP2/NR1H3/FABP5/SORBS1/CD36/ADIPOQ/RXRA/HMGCS1/CPT1A/CPT2/SLC27A5/GK/ACADM/ACOX2/RXRG/ACSL3/RXRB/FABP6/PCK2/SLC27A2/PLIN5/ME1/ACSL5/ACSBG1/SCD/MMP1/FABP3/OLR1/PPARD/ACOX1/FABP1/ACADL	39
KEGG	hsa03010	Ribosome	81/4078	158/8135	0.4176	0.5885	0.4099	RPL39/RPL22L1/RPL35A/MRPS5/MRPL15/RPL27A/FAU/RPL41/RPS7/MRPL22/RPL9/RPL26L1/RPS17/RSL24D1/RPL18/RPS29/MRPL11/RPS9/RPL35/RPL27/RPL34/RPL7/MRPS14/MRPL27/RPL38/RPL30/MRPL13/MRPL3/RPLP2/RPS27L/RPS18/RPS10/RPL37A/MRPL36/MRPL21/MRPS17/MRPL1/MRPL2/RPL36A/RPS24/MRPL14/RPL11/MRPL28/MRPS11/RPL24/MRPL20/MRPS16/MRPS18A/RPL6/RPLP0/RPS21/MRPS15/MRPL17/UBA52/MRPL32/RPS11/RPS15/MRPS2/RPS14/MRPS18C/RPL36/MRPL4/MRPL33/MRPL12/RPL37/RPS3/MRPS7/MRPL23/MRPS12/RPL14/MRPS21/RPS27/RPS27A/RPS8/RPL23A/MRPL34/RPL32/RPS4X/MRPL30/RPL19/MRPL35	81
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14/4078	26/8135	0.4276	0.5976	0.4162	PIGK/PIGF/PIGT/PIGN/PIGP/PIGL/PIGZ/PIGG/PIGA/PIGM/PIGC/MPPE1/PIGU/DPM2	14
KEGG	hsa00790	Folate biosynthesis	14/4078	26/8135	0.4276	0.5976	0.4162	PCBD1/AKR1C3/PTS/MOCS2/GGH/ALPI/CBR1/ALPL/TPH1/AKR1B10/AKR1B1/MOCS1/GCH1/FPGS	14
KEGG	hsa00020	Citrate cycle (TCA cycle)	16/4078	30/8135	0.4332	0.6004	0.4182	SDHA/DLD/SDHC/MDH1/FH/ACLY/IDH3B/OGDH/IDH3A/PCK2/PDHA2/DLST/MDH2/IDH1/SUCLA2/PDHA1	16
KEGG	hsa00030	Pentose phosphate pathway	16/4078	30/8135	0.4332	0.6004	0.4182	PFKM/PRPS2/RBKS/TKT/GLYCTK/PFKL/G6PD/PRPS1/RPE/PGD/PGM1/PGM2/DERA/FBP2/RPIA/ALDOC	16
KEGG	hsa04020	Calcium signaling pathway	122/4078	240/8135	0.4381	0.6023	0.4195	PTK2B/CAMK1/CALML4/ITPKA/FLT4/PDGFB/ITPR3/PLCG1/MCU/ITPR2/ADCY1/GRIN2C/NOS3/ATP2B3/PPP3CB/OXTR/LTB4R2/PRKCB/PRKACB/SLC25A4/PRKACG/PDE1A/PPP3R1/ITPKB/GNA11/PLCB3/VDAC2/HTR5A/RYR3/CACNA1S/ATP2A3/GNA15/CYSLTR1/CACNA1I/GNAS/ATP2A1/PRKACA/P2RX4/CALML5/SLC8A1/CXCR4/PLCD3/MCOLN3/VEGFC/ATP2A2/FGF17/SLC25A6/MST1R/CAMK2B/TBXA2R/GDNF/GRM5/FGF9/CAMK2A/PDGFRA/HGF/P2RX6/ADRA1D/PTGER1/AVPR1B/MYLK3/PTGER3/ASPH/CACNA1G/ATP2B4/P2RX3/FGF16/ADCY9/FGF20/FGF21/TACR1/PLCB1/ADORA2B/FGF19/CACNA1C/CAMK1D/P2RX7/PPIF/ORAI3/EGFR/GNA14/ATP2B1/ERBB3/CALM1/GRIN2D/GRIN2A/BDKRB1/HTR7/PDE1B/CD38/PRKCG/VDAC1/MCOLN2/ITPKC/HTR2C/ADRB2/ADCY3/HTR2A/FGF8/FLT1/CACNA1B/CAMK1G/PDGFRB/SLC25A31/PDGFC/CAMK2G/LHCGR/CACNA1H/FGF5/P2RX5/SLC8A2/EDNRB/PPP3R2/NTSR1/HTR6/FGF18/ADRA1A/EGF/ADRA1B/PLCE1/ORAI1/PDGFA	122
KEGG	hsa00350	Tyrosine metabolism	19/4078	36/8135	0.44	0.6023	0.4195	GOT1L1/IL4I1/ALDH3A1/DBH/GOT2/ADH1A/ADH5/DDC/GOT1/FAH/AOC2/ADH4/HGD/DCT/AOX1/ALDH3B1/HPD/ALDH3B2/GSTZ1	19
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	19/4078	36/8135	0.44	0.6023	0.4195	NADK/NMNAT3/SIRT2/NAMPT/BST1/SIRT1/NMNAT1/NMRK2/ASPDH/NT5M/NNMT/NNT/ENPP1/NADK2/CD38/PNP/AOX1/SIRT4/NT5E	19
KEGG	hsa05033	Nicotine addiction	21/4078	40/8135	0.4437	0.6046	0.4211	GABRQ/CHRNB2/GRIN3B/GRIN2C/GABRD/GABRB2/GRIN2B/SLC17A7/CHRNA4/GRIN2D/GABRB3/GABRG2/GRIN2A/GABRR3/GRIA4/CACNA1B/GABRB1/GABRA3/CHRNA6/SLC32A1/GABRA4	21
KEGG	hsa05332	Graft-versus-host disease	22/4078	42/8135	0.4453	0.6046	0.4211	FAS/TNF/CD86/HLA-G/CD28/HLA-E/IFNG/HLA-B/HLA-DRA/KIR2DL3/KIR3DL3/HLA-C/KIR2DL2/HLA-A/HLA-DMB/KIR2DL1/HLA-DOB/HLA-F/GZMB/FASLG/HLA-DPB1/KLRD1	22
KEGG	hsa03460	Fanconi anemia pathway	28/4078	54/8135	0.4533	0.6123	0.4265	WDR48/FANCL/RPA3/POLI/TELO2/UBE2T/FANCE/SLX4/RMI1/RPA1/EME1/BRIP1/EME2/MUS81/FANCC/RPA4/RAD51C/BRCA1/POLN/BRCA2/RPA2/FANCI/FAN1/TOP3B/POLH/FANCF/REV3L/RMI2	28
KEGG	hsa00240	Pyrimidine metabolism	30/4078	58/8135	0.4555	0.6123	0.4265	CDA/UCK1/NME7/DPYD/ENTPD1/RRM2B/NUDT2/UPP1/CANT1/CAD/DHODH/TK1/ENTPD5/NME3/AK9/RRM2/TYMP/UCKL1/NME1/NT5M/NME6/CMPK2/ENPP1/TYMS/DTYMK/UPB1/TK2/ENTPD6/DPYS/NT5E	30
KEGG	hsa05416	Viral myocarditis	31/4078	60/8135	0.4565	0.6123	0.4265	EIF4G1/ITGAL/CASP3/DAG1/CYCS/RAC2/CCND1/CD86/ICAM1/HLA-G/CD28/HLA-E/ACTB/HLA-B/HLA-DRA/LAMA2/SGCD/ABL1/HLA-C/BID/CASP9/LAMA1/HLA-A/HLA-DMB/HLA-DOB/RAC3/SGCA/EIF4G3/HLA-F/HLA-DPB1/CD40LG	31
KEGG	hsa04911	Insulin secretion	44/4078	86/8135	0.4665	0.6232	0.4341	CREB1/ITPR3/ATP1B1/ATF2/ADCY1/PRKCB/PRKACB/CREB3L2/RIMS2/PRKACG/ATP1A1/KCNMB1/GNA11/PLCB3/CACNA1S/GNAS/PRKACA/ADCYAP1R1/ADCYAP1/CAMK2B/VAMP2/CCK/CAMK2A/FFAR1/ATP1B3/KCNN4/KCNN1/ADCY9/GCK/PLCB1/CACNA1C/GIP/CREB3/PRKCG/KCNJ11/ADCY3/ATP1A2/CAMK2G/FXYD2/RAPGEF4/ATP1A4/ATF4/KCNN3/INS	44
KEGG	hsa04350	TGF-beta signaling pathway	48/4078	94/8135	0.4687	0.6238	0.4344	PPP2CA/RBX1/ACVR2A/BMPR2/PPP2R1A/MYC/SP1/TNF/TGFBR2/SMAD5/SMAD2/ZFYVE16/IFNG/SMAD3/NBL1/TGFBR1/EP300/SMAD1/SMURF2/E2F4/TGIF2/BMP8B/RPS6KB2/FMOD/CDKN2B/ROCK1/RGMB/E2F5/PITX2/NOG/INHBE/NODAL/BMP5/HAMP/ACVR1C/TGIF1/TGFB1/ACVR2B/SMURF1/MAPK1/SKP1/BMPR1A/CHRD/ZFYVE9/BMPR1B/LTBP1/SMAD9/PPP2CB	48
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	8/4078	15/8135	0.5041	0.6565	0.4573	A4GALT/ST3GAL1/FUT2/B3GALT5/FUT1/ST3GAL2/HEXA/GLA	8
KEGG	hsa04966	Collecting duct acid secretion	14/4078	27/8135	0.5054	0.6565	0.4573	ATP6V1G1/ATP6V1E1/ATP6V0A2/ATP6V1C1/ATP4A/ATP6V1D/ATP6V0D1/TCIRG1/ATP6V1B1/ATP6V0E2/ATP6V0A1/ATP6V0D2/ATP4B/CA2	14
KEGG	hsa00051	Fructose and mannose metabolism	17/4078	33/8135	0.506	0.6565	0.4573	PFKM/FPGT/TPI1/HKDC1/HK3/PMM1/ENOSF1/SORD/PFKFB2/MPI/GMPPA/PFKL/AKR1B10/AKR1B1/HK1/FBP2/ALDOC	17
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	19/4078	37/8135	0.5063	0.6565	0.4573	GOT1L1/IL4I1/NAT8L/ASS1/GOT2/GPT2/CAD/CPS1/ABAT/GOT1/GLS/NIT2/RIMKLA/GAD1/GPT/ALDH5A1/ALDH4A1/ASPA/AGXT2	19
KEGG	hsa04975	Fat digestion and absorption	22/4078	43/8135	0.5068	0.6565	0.4573	APOA1/PLA2G2A/FABP2/CD36/SCARB1/APOA4/GOT2/ACAT2/LIPF/PNLIPRP2/NPC1L1/DGAT1/ABCA1/PLA2G5/PNLIP/PLA2G2D/APOB/PLA2G2F/MOGAT3/PLA2G12B/PNLIPRP1/FABP1	22
KEGG	hsa02010	ABC transporters	23/4078	45/8135	0.507	0.6565	0.4573	ABCA5/ABCC10/ABCA9/ABCB1/ABCC3/ABCC12/ABCD4/ABCB7/ABCD1/CFTR/ABCA1/ABCA3/DEFB1/ABCB10/ABCC11/ABCB11/ABCG2/ABCD3/ABCD2/ABCB9/ABCB6/TAP2/ABCA6	23
KEGG	hsa04927	Cortisol synthesis and secretion	33/4078	65/8135	0.5084	0.6565	0.4573	CREB1/ITPR3/SP1/NCEH1/ATF2/ITPR2/ADCY1/PRKACB/CREB3L2/SCARB1/PRKACG/GNA11/PLCB3/CACNA1S/NR5A1/CACNA1I/GNAS/PRKACA/CYP17A1/MRAP/CACNA1G/ADCY9/KCNK3/PLCB1/CACNA1C/AGT/CREB3/NR4A1/ADCY3/CACNA1H/KCNA4/ATF4/ORAI1	33
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	39/4078	77/8135	0.5091	0.6565	0.4573	CACNB2/DAG1/CACNA2D2/CACNG8/TCF7L2/ITGAV/ACTB/CACNB1/ITGA4/CACNA1S/LAMA2/ATP2A3/ITGB4/ATP2A1/SGCD/SLC8A1/ATP2A2/ITGB5/LMNA/LAMA1/ACTN2/ITGA5/ITGA6/EMD/CACNA1C/ITGA3/CACNG4/ITGA8/CTNNA2/ITGA11/SGCA/CTNNA1/LEF1/CACNB3/DES/CACNG2/SLC8A2/ITGA10/CACNG5	39
KEGG	hsa00230	Purine metabolism	64/4078	128/8135	0.5472	0.7016	0.4887	PDE4A/NME7/PRPS2/ATIC/ENTPD1/PFAS/AK2/RRM2B/IMPDH2/NUDT2/ADCY1/CANT1/ADPRM/GUCY2D/PDE1A/ADCY10/ENTPD5/NME3/AK9/PAICS/RRM2/NUDT5/PAPSS1/AK6/HDDC3/ENPP4/GMPR2/AMPD2/NME1/NT5M/PDE10A/HPRT1/PRPS1/FHIT/GART/NME6/ADCY9/PDE7A/PGM1/ENPP1/NUDT16/AK8/PGM2/PDE4B/ALLC/PDE1B/GDA/GUCY2F/LACC1/GUK1/GUCY2C/PNP/PDE5A/ADCY3/GMPS/PDE7B/ENTPD6/AMPD3/PDE3B/NPR2/NT5E/GMPR/AK7/NUDT9	64
KEGG	hsa04972	Pancreatic secretion	51/4078	102/8135	0.5501	0.7016	0.4887	ITPR3/ATP1B1/ITPR2/CTRL/ADCY1/PLA2G2A/ATP2B3/CELA2B/PRKCB/RAB11A/ATP1A1/RAB8A/SLC4A4/PLCB3/PRSS2/PNLIPRP2/ATP2A3/GNAS/ATP2A1/RAP1B/BST1/PRSS3/ATP2A2/CFTR/TRPC1/SLC26A3/CCK/RAB3D/SCTR/ATP1B3/ATP2B4/ADCY9/PLCB1/SLC12A2/CPA1/PLA2G5/ATP2B1/CELA3A/PNLIP/PLA2G2D/PLA2G2F/CD38/PRKCG/ADCY3/ATP1A2/CLCA2/FXYD2/PLA2G12B/CA2/PNLIPRP1/ATP1A4	51
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	50/4078	100/8135	0.5504	0.7016	0.4887	IL2RG/IL34/TNFRSF1B/TNF/IL22RA1/CCL13/IL20RA/TNFSF10/CCL20/CCR5/IL18/CXCL10/TNFRSF10A/CXCL9/IL2RB/CCR2/CX3CL1/IL24/CXCL5/ACKR4/CXCR4/IL6R/CCR7/CCR10/CXCR2/CXCL6/IL18R1/LTBR/CCL27/CCL18/CCL21/CCL16/CXCL8/CCL5/CCL23/CCL22/CCL26/LTA/TNFRSF10C/PF4/CCL19/CXCL1/PF4V1/IL20/CXCR1/IL20RB/TNFRSF10D/PPBP/CCL24/TNFRSF14	50
KEGG	hsa05330	Allograft rejection	19/4078	38/8135	0.5708	0.7248	0.5049	FAS/TNF/CD86/HLA-G/CD28/HLA-E/IFNG/HLA-B/HLA-DRA/IL5/HLA-C/HLA-A/HLA-DMB/HLA-DOB/HLA-F/GZMB/FASLG/HLA-DPB1/CD40LG	19
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	15/4078	30/8135	0.578	0.7312	0.5093	DLD/MDH1/AFMID/GLYCTK/MCEE/ACAT2/HOGA1/ACSS2/ACSS1/SHMT1/GRHPR/PCCA/AMT/HYI/MDH2	15
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	12/4078	24/8135	0.5857	0.7382	0.5142	XYLT2/GLCE/HS6ST2/HS2ST1/B3GALT6/HS3ST1/EXTL1/EXTL2/B3GAT3/HS6ST3/B4GALT7/NDST2	12
KEGG	hsa05323	Rheumatoid arthritis	46/4078	93/8135	0.5923	0.7401	0.5155	ITGAL/ATP6V1G1/ATP6V1E1/ATP6V0A2/ATP6V1C1/TNFSF13B/ATP6V0B/TNF/IL15/ATP6V1D/CD86/ICAM1/CD28/CCL20/IFNG/IL18/HLA-DRA/TLR4/CXCL5/CTSL/ATP6V0D1/JUN/TCIRG1/ATP6V1B1/IL11/ATP6V0E2/CXCL6/ACP5/FOS/CSF2/ATP6V0A1/HLA-DMB/IL17A/CXCL8/CCL5/ATP6V1H/ANGPT1/HLA-DOB/TGFB1/CTSK/CXCL1/ATP6V0D2/FLT1/HLA-DPB1/MMP1/LTB	46
KEGG	hsa00100	Steroid biosynthesis	10/4078	20/8135	0.5928	0.7401	0.5155	CYP24A1/SC5D/HSD17B7/EBP/FDFT1/LBR/MSMO1/SOAT2/CYP27B1/TM7SF2	10
KEGG	hsa04976	Bile secretion	44/4078	89/8135	0.5939	0.7401	0.5155	SLC22A7/NCEH1/ATP1B1/ADCY1/PRKACB/SCARB1/SULT2A1/RXRA/PRKACG/ABCB1/ATP1A1/ABCC3/SLC4A4/SLC27A5/UGT2B15/GNAS/AQP4/PRKACA/UGT2B4/CFTR/BAAT/SLC10A2/SCTR/ATP1B3/CYP3A4/UGT1A1/ADCY9/AQP8/ABCB11/UGT1A6/ABCG2/SLC4A5/HMGCR/SLC10A1/AQP9/UGT2A3/ADCY3/ATP1A2/FXYD2/UGT2B28/CA2/SLCO1A2/ATP1A4/AQP1	44
KEGG	hsa04080	Neuroactive ligand-receptor interaction	175/4078	353/8135	0.6054	0.7455	0.5193	P2RY8/LPAR6/P2RY13/APLN/SSTR1/PARD3/ADORA1/NPFFR1/GABRQ/CHRNB2/LEP/CALCR/GRM3/CRHR1/CGA/GZMA/PATE1/CHRNB1/GALP/GRIN3B/RXFP3/CHRND/GALR2/GRIN2C/PRLH/S1PR2/OPRK1/CRH/OXTR/LTB4R2/C5AR1/GABRD/NPY/SSTR3/C5/GABRB2/BRS3/GLRA3/GH1/MC4R/P2RY6/SSTR4/ADM2/HTR5A/PRSS2/CALCRL/KNG1/CYSLTR1/UCN2/RLN2/GRIN2B/P2RX4/ADCYAP1R1/OPRL1/GRIK5/MTNR1B/PTGER4/GHRH/GHSR/PRSS3/PRLR/ADCYAP1/S1PR3/THRA/TBXA2R/HTR1A/GRM5/GRID1/PDYN/CCK/HCRTR2/P2RX6/SCTR/GRM4/ADRA1D/PTGER1/AVPR1B/PTGER3/GALR1/HTR1E/GLRB/NPW/FSHR/DRD2/RXFP1/P2RX3/CHRNA4/F2RL3/TACR1/INSL5/PPY/HRH3/ADORA2B/EDN1/NPY5R/F2RL1/LTB4R/HCRT/AGT/NTS/P2RX7/MC1R/GHRHR/TSHR/NPY2R/S1PR5/S1PR1/GIP/GRIK4/EDN2/TAAR1/SLURP1/HCRTR1/NMUR1/GNRH2/KISS1/GRIN2D/GABRB3/GABRG2/GRIN2A/GABRR3/HTR1F/P2RY14/GRP/OPRM1/TRH/GNRHR/BDKRB1/MC5R/HTR7/AVP/LPAR1/GRIA4/CALCA/FPR3/UCN/ADRA2C/CHRNA9/HTR2C/ADRB2/ADM/CHRNG/HTR2A/PTH1R/PMCH/NPFF/LHCGR/P2RX5/GRM8/GRIK2/MTNR1A/PYY/GPHA2/GABRB1/HTR1D/INSL3/OPRD1/EDNRB/S1PR4/GABRA3/CHRNA6/AVPR2/NPBWR1/GABBR2/HTR1B/FSHB/NTSR1/HTR6/PTGER2/GPR83/ADRA1A/GH2/ADRA1B/GABRA4/GPR156	175
KEGG	hsa00310	Lysine degradation	31/4078	63/8135	0.6077	0.7455	0.5193	DLD/ASH1L/CAMKMT/SETDB1/DOT1L/ALDH9A1/SETD1B/ALDH3A2/ECHS1/ACAT2/PLOD3/SETMAR/KMT2E/TMLHE/PLOD2/AASS/PRDM6/SETD1A/ALDH2/KMT2C/PHYKPL/DLST/EZH2/COLGALT1/KMT2B/KMT2D/PRDM16/ALDH1B1/EHMT2/HADHA/SMYD1	31
KEGG	hsa04623	Cytosolic DNA-sensing pathway	31/4078	63/8135	0.6077	0.7455	0.5193	TBK1/POLR2K/CASP1/IRF3/NFKB1/POLR3F/NFKBIB/AIM2/RIPK1/DDX58/IL18/CHUK/CXCL10/POLR2E/IRF7/IL33/IKBKB/ADAR/IFNA8/POLR3D/POLR3H/POLR3G/POLR3A/POLR3K/IFNA16/CCL5/POLR3GL/MAVS/ZBP1/IFNB1/POLR1C	31
KEGG	hsa00590	Arachidonic acid metabolism	30/4078	61/8135	0.6091	0.7455	0.5193	PTGS2/AKR1C3/PLA2G4A/GPX2/GGT1/CBR1/PLA2G2A/PTGS1/GPX3/PTGES/PTGES2/ALOX5/PLA2G4F/ALOX12B/CYP4F8/CYP2B6/EPHX2/PLA2G5/CYP4F3/PLA2G2D/CBR3/PLA2G2F/PLA2G4D/PLA2G4C/PTGIS/GPX5/PLA2G12B/GPX8/ALOX12/CYP2C9	30
KEGG	hsa04145	Phagosome	75/4078	152/8135	0.6094	0.7455	0.5193	STX7/M6PR/ATP6V1G1/TFRC/ATP6V1E1/ATP6V0A2/FCAR/SEC61B/ATP6V1C1/CLEC7A/DYNC1LI2/SEC22B/RAB5C/MRC2/ATP6V0B/ITGAV/RAB7A/TUBA4A/FCGR1A/ATP6V1D/HLA-G/FCGR2C/TUBA8/HLA-E/COLEC12/ACTB/CD36/CALR/SCARB1/VAMP3/HLA-B/SEC61G/STX18/HLA-DRA/FCGR2B/TLR4/CLEC4M/TUBB1/CD209/TUBB4B/SEC61A1/CTSL/ITGB5/DYNC1I2/ATP6V0D1/HLA-C/HGS/TCIRG1/ATP6V1B1/ATP6V0E2/TUBB2B/THBS3/HLA-A/ITGA5/ATP6V0A1/DYNC1LI1/HLA-DMB/RAB5B/FCGR2A/ATP6V1H/TUBA1A/EEA1/HLA-DOB/MSR1/HLA-F/ATP6V0D2/HLA-DPB1/TAP2/MRC1/MPO/TUBB3/OLR1/CTSS/FCGR3B/THBS2	75
KEGG	hsa00920	Sulfur metabolism	5/4078	10/8135	0.6263	0.7634	0.5317	IMPAD1/SUOX/ETHE1/BPNT1/PAPSS1	5
KEGG	hsa04216	Ferroptosis	20/4078	41/8135	0.629	0.764	0.5321	TFRC/ATG5/TF/TP53/HMOX1/GCLC/VDAC2/MAP1LC3A/MAP1LC3B/SAT1/ACSL3/NCOA4/ATG7/STEAP3/MAP1LC3C/SLC39A8/ACSL5/LPCAT3/SAT2/GSS	20
KEGG	hsa04514	Cell adhesion molecules	73/4078	149/8135	0.6415	0.7729	0.5383	ITGAL/GLG1/CDH15/CD58/CD99/ITGAV/NLGN2/CNTN2/CD86/ICAM1/HLA-G/CD28/HLA-E/CD6/PDCD1/HLA-B/HLA-DRA/CLDN7/MAG/CD4/ITGA4/SELL/CD34/NRCAM/CDH5/CLDN2/CD274/CD99L2/ICOS/PDCD1LG2/HLA-C/PVR/CD8A/CLDN5/L1CAM/CLDN11/CDH4/HLA-A/ITGA6/SELPLG/CLDN8/HLA-DMB/NEGR1/IGSF11/CD226/NFASC/OCLN/ITGA8/NRXN2/TIGIT/SPN/HLA-DOB/NLGN4Y/NTNG2/CLDN10/CD22/VCAN/HLA-F/CNTNAP1/SIGLEC1/CDH1/CLDN9/HLA-DPB1/CNTN1/SDC1/CLDN16/ICAM2/NLGN4X/LRRC4C/CD276/CD40LG/CLDN18/LRRC4B	73
KEGG	hsa04721	Synaptic vesicle cycle	38/4078	78/8135	0.6421	0.7729	0.5383	CLTB/ATP6V1G1/ATP6V1E1/ATP6V0A2/ATP6V1C1/NAPA/SLC6A7/AP2M1/ATP6V0B/AP2B1/SLC6A4/ATP6V1D/AP2S1/CLTC/AP2A2/SLC1A6/CLTA/ATP6V0D1/TCIRG1/SLC6A12/CPLX3/VAMP2/ATP6V1B1/ATP6V0E2/SLC17A7/ATP6V0A1/NSF/DNM3/SLC6A1/ATP6V1H/AP2A1/CPLX2/UNC13C/ATP6V0D2/CACNA1B/UNC13A/SLC32A1/SLC1A3	38
KEGG	hsa05133	Pertussis	37/4078	76/8135	0.6436	0.7729	0.5383	LY96/CASP3/CASP1/GNAI2/MAPK8/CFL1/IRF3/NFKB1/C1QA/CALML4/TNF/C1QB/C1QC/MAPK14/C5/TLR4/CXCL5/GNAI3/CALML5/C1S/JUN/CXCL6/ITGA5/TIRAP/NOD1/FOS/CXCL8/TRAF6/IRAK1/SERPING1/CALM1/MYD88/IRF1/MAPK13/MAPK1/MAPK12/C4BPA	37
KEGG	hsa00052	Galactose metabolism	15/4078	31/8135	0.6456	0.7729	0.5383	PFKM/B4GALT2/HKDC1/HK3/GANC/GALE/GALT/PFKL/AKR1B10/GCK/AKR1B1/PGM1/PGM2/HK1/GLA	15
KEGG	hsa04614	Renin-angiotensin system	11/4078	23/8135	0.666	0.7921	0.5517	CMA1/THOP1/PRCP/AGT/PREP/KLK1/MME/ACE/ANPEP/KLK2/ACE2	11
KEGG	hsa04640	Hematopoietic cell lineage	48/4078	99/8135	0.6664	0.7921	0.5517	TFRC/CD59/CD3G/TNF/CD3E/FCGR1A/IL7R/CSF3R/EPO/CD7/CD36/HLA-DRA/IL11RA/IL3RA/GP1BA/CD4/IL5/ITGA4/CD34/FLT3LG/CD37/IL6R/KITLG/CD1A/IL11/CD8A/ITGA5/ITGA6/CSF2/EPOR/HLA-DMB/CSF3/ITGA3/GP5/DNTT/MS4A1/HLA-DOB/MME/CD22/CD38/CD3D/FCER2/GP9/HLA-DPB1/ANPEP/IL7/CD1B/CD44	48
KEGG	hsa04979	Cholesterol metabolism	24/4078	50/8135	0.6713	0.795	0.5537	ANGPTL4/APOC1/APOC2/APOA1/NCEH1/VAPA/CD36/LDLRAP1/SCARB1/APOA4/LPA/SORT1/VDAC2/PCSK9/OSBPL5/ABCA1/SOAT2/STARD3/ABCB11/APOE/APOB/VDAC1/NPC2/MYLIP	24
KEGG	hsa00531	Glycosaminoglycan degradation	9/4078	19/8135	0.6805	0.8031	0.5594	ARSB/HPSE/GNS/HYAL4/GUSB/HEXA/HYAL2/IDS/GALNS	9
KEGG	hsa00910	Nitrogen metabolism	8/4078	17/8135	0.6895	0.8109	0.5648	CA14/CPS1/CA8/CA1/CA9/CA12/CA6/CA2	8
KEGG	hsa04060	Cytokine-cytokine receptor interaction	144/4078	295/8135	0.6983	0.8184	0.57	IL1RN/IL27RA/ACVR2A/FAS/BMPR2/IL2RG/TNFSF13B/IL34/TNFRSF1B/LEP/TNF/TNFRSF13B/TGFBR2/IL22RA1/GDF2/NGFR/CCL13/IL15/IL7R/INHA/IL20RA/IL16/IFNGR1/GDF10/IL23R/CSF3R/IL17RE/IL25/CXCL16/TNFSF10/EPO/CCL20/IFNG/CCR5/IL32/IL18/GH1/TGFBR1/CXCL10/EBI3/IL13/IL11RA/IL3RA/TNFRSF17/CD4/IL5/TNFRSF10A/CXCL9/CTF1/IL2RB/IFNW1/CCR2/CX3CL1/CXCR6/TNFSF8/IL24/IL36B/IL36A/CXCL5/BMP8B/IL12RB1/IL1RL2/EDA2R/IL33/ACKR4/CXCR4/IL6R/TNFRSF19/IFNA8/CCR7/PRLR/CCR10/IFNAR1/CXCR2/IL11/TSLP/CXCL6/EDAR/IL18R1/LTBR/CSF2/EPOR/CCL27/INHBE/CCL18/CCL21/IL17A/TNFRSF9/LIFR/CCL16/CSF3/CXCL8/IFNA16/IL12RB2/NODAL/CCL5/BMP5/CCL23/CCL22/TNFRSF8/ACVR1C/TNFRSF11B/IL26/CD27/CCL26/TNFRSF4/LTA/TGFB1/ACVR2B/TNFRSF10C/PF4/CCL19/IL21R/GDF11/IFNAR2/CXCL1/BMP10/BMPR1A/IL17B/PF4V1/IL17F/FASLG/IFNK/IL20/IL1RAP/TNFRSF25/RELT/IFNB1/BMPR1B/CXCR1/CXCL17/IL1RL1/CD40LG/IL20RB/CNTF/IL7/EDA/LTB/TNFRSF10D/TNFRSF21/PPBP/CCL24/TNFRSF14/GH2	144
KEGG	hsa00040	Pentose and glucuronate interconversions	16/4078	34/8135	0.7019	0.8197	0.5709	DCXR/AKR1A1/UGT2B15/SORD/KL/UGT2B4/GUSB/AKR1B10/UGDH/RPE/UGT1A1/AKR1B1/DHDH/UGT1A6/UGT2A3/UGT2B28	16
KEGG	hsa00053	Ascorbate and aldarate metabolism	14/4078	30/8135	0.7129	0.8296	0.5779	ALDH9A1/ALDH3A2/AKR1A1/UGT2B15/KL/UGT2B4/GUSB/UGDH/UGT1A1/ALDH2/UGT1A6/UGT2A3/ALDH1B1/UGT2B28	14
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	37/4078	78/8135	0.7229	0.8383	0.5839	GSTO1/CYP2A7/ALDH3A1/CBR1/SULT2A1/ADH1A/UGT2B15/GSTM1/UGT2B4/CYP1A1/ADH5/CYP2D6/CYP2A6/GSTA3/ADH4/GSTM4/CYP3A4/UGT1A1/GSTK1/DHDH/CYP2B6/UGT1A6/GSTM2/UGT2A3/CBR3/GSTP1/MGST3/HSD11B1L/CYP1A2/ALDH3B1/HSD11B1/GSTO2/UGT2B28/CYP1B1/CYP2C9/GSTA1/ALDH3B2	37
KEGG	hsa00982	Drug metabolism - cytochrome P450	34/4078	72/8135	0.7302	0.8439	0.5878	GSTO1/CYP2A7/ALDH3A1/ADH1A/UGT2B15/GSTM1/UGT2B4/FMO4/ADH5/FMO2/CYP2D6/FMO3/CYP2A6/GSTA3/FMO5/ADH4/GSTM4/CYP3A4/UGT1A1/GSTK1/CYP2B6/UGT1A6/GSTM2/UGT2A3/GSTP1/MGST3/AOX1/CYP1A2/ALDH3B1/GSTO2/UGT2B28/CYP2C9/GSTA1/ALDH3B2	34
KEGG	hsa01232	Nucleotide metabolism	40/4078	85/8135	0.7511	0.8634	0.6014	CDA/UCK1/NME7/ENTPD1/AK2/RRM2B/IMPDH2/UPP1/CANT1/TK1/ENTPD5/NME3/AK9/RRM2/TYMP/AK6/UCKL1/GMPR2/AMPD2/NME1/NT5M/HPRT1/NME6/CMPK2/ENPP1/TYMS/DTYMK/NUDT16/AK8/GDA/LACC1/GUK1/PNP/GMPS/TK2/ENTPD6/AMPD3/NT5E/GMPR/AK7	40
KEGG	hsa00670	One carbon pool by folate	9/4078	20/8135	0.7523	0.8634	0.6014	MTHFD2/ATIC/MTHFD1/MTR/MTFMT/SHMT1/GART/TYMS/AMT	9
KEGG	hsa05140	Leishmaniasis	36/4078	77/8135	0.761	0.8694	0.6056	PTGS2/NFKB1/JAK1/NFKBIB/JAK2/PTPN6/TNF/FCGR1A/IFNGR1/FCGR2C/PRKCB/IFNG/MAPK14/HLA-DRA/ITGA4/EEF1A2/TLR4/JUN/STAT1/EEF1A1/FOS/ELK1/HLA-DMB/MARCKSL1/TRAF6/IRAK1/FCGR2A/MYD88/HLA-DOB/MAPK13/TGFB1/MAPK1/MAPK12/HLA-DPB1/MAP3K7/FCGR3B	36
KEGG	hsa00511	Other glycan degradation	8/4078	18/8135	0.7633	0.8694	0.6056	MAN2B1/NEU4/MAN2B2/FUCA2/NEU1/MAN2C1/HEXA/ENGASE	8
KEGG	hsa05146	Amoebiasis	48/4078	102/8135	0.7653	0.8694	0.6056	PIK3CA/CASP3/RAB5C/NFKB1/TNF/RAB7A/ADCY1/PIK3R2/COL4A4/PRKCB/PRKACB/IFNG/VCL/PRKACG/PIK3R1/LAMA4/PIK3CB/GNA11/PLCB3/LAMA2/GNA15/TLR4/GNAS/ARG2/PRKACA/ACTN4/PRDX1/LAMC2/HSPB1/CD1A/SERPINB9/LAMA1/LAMB1/CSF2/PLCB1/CXCL8/SERPINB6/RAB5B/LAMB2/GNA14/COL4A3/MUC2/TGFB1/PRKCG/CXCL1/C8G/ARG1/CD1B	48
KEGG	hsa00500	Starch and sucrose metabolism	16/4078	36/8135	0.8024	0.9082	0.6326	HKDC1/HK3/GANC/GYG1/AGL/GCK/PGM1/ENPP1/GYG2/GBA3/PGM2/HK1/PYGM/PGM2L1/GYS2/TREH	16
KEGG	hsa04970	Salivary secretion	43/4078	93/8135	0.8049	0.9082	0.6326	CALML4/ITPR3/TRPV6/ATP1B1/ITPR2/ADCY1/ATP2B3/PRKCB/PRKACB/PRKACG/ATP1A1/PLCB3/RYR3/CST4/GNAS/PRKACA/CALML5/BST1/VAMP2/CST1/ADRA1D/CAMP/DMBT1/ATP1B3/ATP2B4/KCNN4/ADCY9/PLCB1/SLC12A2/CST3/ATP2B1/CALM1/CD38/PRKCG/ADRB2/ADCY3/ATP1A2/MUC7/MUC5B/FXYD2/ATP1A4/ADRA1A/ADRA1B	43
KEGG	hsa04610	Complement and coagulation cascades	39/4078	85/8135	0.8149	0.9164	0.6383	CD59/F7/C1QA/SERPINF2/CD46/C1QB/C1QC/C5AR1/SERPINA1/C5/F8/C7/SERPINC1/KNG1/SERPINE1/F13A1/FGB/C1S/MASP2/CFB/CFH/VWF/SERPINB2/F2RL3/PROCR/F3/CFI/SERPING1/F5/FGG/F11/F10/CFHR5/BDKRB1/CFHR3/F9/C8G/C4BPA/PLAUR	39
KEGG	hsa01523	Antifolate resistance	13/4078	30/8135	0.8234	0.9228	0.6428	NFKB1/ATIC/TNF/GGH/CHUK/ABCC3/IKBKB/SHMT1/GART/TYMS/ABCG2/FPGS/ALOX12	13
KEGG	hsa00120	Primary bile acid biosynthesis	7/4078	17/8135	0.8368	0.9336	0.6503	HSD17B4/SLC27A5/ACOX2/BAAT/AMACR/AKR1D1/CYP39A1	7
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	31/4078	69/8135	0.8386	0.9336	0.6503	PTGS2/NAT1/GSTO1/CYP2A7/CBR1/SULT2A1/UGT2B15/GSTM1/UGT2B4/CYP1A1/CYP2A6/GSTA3/NAT2/GSTM4/CYP3A4/UGT1A1/GSTK1/UGT1A6/GSTM2/UGT2A3/GSTP1/MGST3/HSD11B1L/CYP1A2/HSD11B1/GSTO2/UGT2B28/CYP1B1/CYP2C9/GSTA1/SULT1A2	31
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/4078	15/8135	0.8517	0.9451	0.6582	ST6GALNAC3/ST3GAL1/ST3GAL2/HEXA/ST6GALNAC5/B3GALT4	6
KEGG	hsa00260	Glycine, serine and threonine metabolism	17/4078	40/8135	0.87	0.9537	0.6643	DLD/SARDH/PGAM1/GLYCTK/GAMT/SDS/PHGDH/BPGM/SHMT1/AOC2/SRR/GRHPR/AMT/GATM/BHMT/DAO/AGXT2	17
KEGG	hsa00591	Linoleic acid metabolism	12/4078	29/8135	0.8709	0.9537	0.6643	PLA2G4A/PLA2G2A/PLA2G4F/CYP3A4/PLA2G5/PLA2G2D/PLA2G2F/PLA2G4D/CYP1A2/PLA2G4C/PLA2G12B/CYP2C9	12
KEGG	hsa04392	Hippo signaling pathway - multiple species	12/4078	29/8135	0.8709	0.9537	0.6643	DCHS1/TEAD2/LIMD1/DCHS2/WTIP/STK3/RASSF1/TEAD1/YAP1/LATS2/MOB1A/TEAD3	12
KEGG	hsa04744	Phototransduction	12/4078	29/8135	0.8709	0.9537	0.6643	GNB1/CALML4/SLC24A1/GUCY2D/GRK1/CALML5/GUCA1C/CALM1/GNAT2/GUCY2F/RHO/GNGT1	12
KEGG	hsa04217	Necroptosis	73/4078	159/8135	0.8758	0.956	0.6658	CHMP5/CAPN2/FAS/CASP1/MAPK8/PLA2G4A/USP21/CAPN1/BIRC2/JAK1/JAK2/TNF/PARP1/BCL2/IRF9/CHMP1A/IFNGR1/PGAM5/TNFSF10/CHMP6/RIPK1/IFNG/SLC25A4/SPATA2L/CHMP1B/TRAF5/JAK3/VDAC2/TNFRSF10A/TLR4/AIFM1/HMGB1/STAT2/RNF31/CHMP7/IL33/IFNA8/SLC25A6/CAMK2B/CHMP2B/IFNAR1/STAT1/BID/CAMK2A/PLA2G4F/STAT5A/STAT6/IFNA16/SHARPIN/EIF2AK2/XIAP/RBCK1/PYGM/BIRC3/TLR3/ZBP1/SQSTM1/VDAC1/IFNAR2/PLA2G4D/BAX/HSP90AA1/PLA2G4C/VPS4B/FASLG/PPIA/SLC25A31/CAMK2G/VPS4A/IFNB1/TRADD/CHMP4C/FADD	73
KEGG	hsa04973	Carbohydrate digestion and absorption	20/4078	47/8135	0.8827	0.957	0.6665	PIK3CA/AKT1/AKT2/ATP1B1/PIK3R2/HKDC1/PRKCB/HK3/PIK3R1/ATP1A1/PIK3CB/PLCB3/ATP1B3/PLCB1/HK1/ATP1A2/GNAT3/AKT3/FXYD2/ATP1A4	20
KEGG	hsa00061	Fatty acid biosynthesis	7/4078	18/8135	0.8835	0.957	0.6665	FASN/OXSM/ACACB/ACSL3/CBR4/ACSL5/ACSBG1	7
KEGG	hsa00592	alpha-Linolenic acid metabolism	10/4078	25/8135	0.8881	0.957	0.6665	PLA2G4A/PLA2G2A/PLA2G4F/PLA2G5/PLA2G2D/PLA2G2F/PLA2G4D/PLA2G4C/PLA2G12B/ACOX1	10
KEGG	hsa04742	Taste transduction	38/4078	86/8135	0.8882	0.957	0.6665	SCNN1A/ITPR3/TRPM5/PRKACB/HCN4/PRKACG/TAS2R14/PDE1A/TAS1R1/PLCB3/GNB3/KCNK5/PRKACA/CALHM1/SCN3A/HTR1A/PKD2L1/GRM4/HTR1E/SCNN1G/P2RX3/PLCB1/CACNA1C/TAS2R40/HTR1F/PDE1B/GNAT3/SCNN1B/TAS2R5/HTR1D/TAS2R8/HTR3B/GABRA3/TAS2R50/GABBR2/HTR1B/TAS2R9/GABRA4	38
KEGG	hsa00515	Mannose type O-glycan biosynthesis	9/4078	23/8135	0.8975	0.9639	0.6714	FKRP/POMT2/B4GALT2/POMT1/CHST10/POMGNT1/FUT4/POMGNT2/POMK	9
KEGG	hsa01212	Fatty acid metabolism	24/4078	57/8135	0.9115	0.9745	0.6788	FASN/CPT1C/ELOVL5/OXSM/HSD17B4/ECHS1/ACAT2/CPT1A/CPT2/ACADM/HADHB/ACADS/ACSL3/ACADSB/ELOVL7/CBR4/PPT1/ACSL5/ACSBG1/SCD/HADHA/ELOVL2/ACOX1/ACADL	24
KEGG	hsa05150	Staphylococcus aureus infection	42/4078	96/8135	0.9133	0.9745	0.6788	ITGAL/FCAR/C1QA/KRT16/FCGR1A/ICAM1/FCGR2C/C1QB/C1QC/C5AR1/C5/HLA-DRA/FCGR2B/DEFA5/KRT20/C1S/DEFA4/MASP2/CFB/CFH/CAMP/DSG1/KRT24/DEFB1/SELPLG/HLA-DMB/KRT19/KRT33B/CFI/FGG/FCGR2A/HLA-DOB/KRT36/FPR3/KRT38/DEFA6/HLA-DPB1/KRT9/KRT15/KRT13/KRT10/FCGR3B	42
KEGG	hsa00565	Ether lipid metabolism	20/4078	49/8135	0.927	0.9829	0.6846	LPCAT4/AGPS/PLA2G4A/PLD3/PAFAH2/PLA2G2A/CEPT1/LPCAT2/LPCAT1/PLD2/PLA2G4F/GDPD1/PLA2G5/PAFAH1B2/PLA2G2D/CHPT1/PLA2G2F/PLA2G4D/PLA2G4C/PLA2G12B	20
KEGG	hsa04672	Intestinal immune network for IgA production	20/4078	49/8135	0.927	0.9829	0.6846	TNFSF13B/TNFRSF13B/IL15/CD86/CD28/HLA-DRA/TNFRSF17/IL5/ITGA4/CXCR4/CCR10/ICOS/LTBR/HLA-DMB/HLA-DOB/TGFB1/PIGR/AICDA/HLA-DPB1/CD40LG	20
KEGG	hsa00450	Selenocompound metabolism	6/4078	17/8135	0.9299	0.9829	0.6846	MTR/SEPHS2/PAPSS1/PSTK/TXNRD1/SEPSECS	6
KEGG	hsa00140	Steroid hormone biosynthesis	25/4078	61/8135	0.9412	0.9917	0.6907	SRD5A1/AKR1C3/STS/CYP11B2/HSD17B7/HSD17B2/UGT2B15/UGT2B4/CYP1A1/CYP17A1/CYP3A4/UGT1A1/UGT1A6/SULT2B1/AKR1D1/SRD5A2/DHRS11/UGT2A3/HSD11B1L/CYP1A2/HSD11B1/HSD17B1/UGT2B28/CYP1B1/HSD17B3	25
KEGG	hsa05320	Autoimmune thyroid disease	21/4078	53/8135	0.9532	1	0.6965	FAS/CGA/CD86/HLA-G/CD28/HLA-E/HLA-B/HLA-DRA/IL5/IFNA8/HLA-C/HLA-A/HLA-DMB/IFNA16/TSHR/HLA-DOB/HLA-F/GZMB/FASLG/HLA-DPB1/CD40LG	21
KEGG	hsa04950	Maturity onset diabetes of the young	9/4078	26/8135	0.9635	1	0.6965	HNF1A/ONECUT1/HNF1B/HHEX/GCK/MNX1/HNF4A/NEUROD1/INS	9
KEGG	hsa05310	Asthma	11/4078	31/8135	0.966	1	0.6965	FCER1G/TNF/EPX/IL13/HLA-DRA/IL5/HLA-DMB/HLA-DOB/HLA-DPB1/RNASE3/CD40LG	11
KEGG	hsa00830	Retinol metabolism	27/4078	68/8135	0.9681	1	0.6965	CYP2W1/RDH11/ALDH1A2/CYP2A7/ADH1A/UGT2B15/UGT2B4/CYP1A1/ADH5/DGAT1/CYP2A6/ADH4/DHRS9/CYP3A4/UGT1A1/CYP2B6/RDH10/UGT1A6/PNPLA4/RPE65/UGT2A3/AOX1/CYP1A2/DHRS3/CYP27C1/UGT2B28/CYP2C9	27
KEGG	hsa05144	Malaria	19/4078	50/8135	0.9692	1	0.6965	ITGAL/TNF/ICAM1/KLRB1/IFNG/CD36/IL18/TLR4/HGF/THBS3/CSF3/CXCL8/MYD88/TGFB1/SDC1/GYPB/CD40LG/GYPC/THBS2	19
KEGG	hsa04974	Protein digestion and absorption	42/4078	103/8135	0.978	1	0.6965	SLC16A10/COL16A1/COL27A1/COL20A1/ATP1B1/CTRL/COL4A4/COL5A1/CELA2B/COL6A1/ATP1A1/PRSS2/SLC38A2/COL14A1/KCNK5/COL26A1/SLC8A1/PRSS3/SLC7A8/KCNJ13/SLC36A4/COL23A1/COL2A1/ATP1B3/KCNN4/PRCP/CPA1/SLC1A5/CELA3A/COL4A3/COL12A1/COL7A1/MME/COL9A2/COL11A1/ATP1A2/FXYD2/SLC6A19/SLC3A1/SLC8A2/ATP1A4/ACE2	42
KEGG	hsa00860	Porphyrin metabolism	15/4078	43/8135	0.9851	1	0.6965	HCCS/COX15/BLVRA/EARS2/HMOX1/UGT2B15/FXN/UGT2B4/GUSB/FECH/UGT1A1/UGT1A6/UGT2A3/COX10/UGT2B28	15
KEGG	hsa00062	Fatty acid elongation	8/4078	27/8135	0.9909	1	0.6965	ELOVL5/ECHS1/HADHB/THEM4/ELOVL7/PPT1/HADHA/ELOVL2	8
KEGG	hsa00600	Sphingolipid metabolism	18/4078	52/8135	0.9918	1	0.6965	UGCG/NEU4/GALC/SPTLC2/CERS6/ENPP7/B4GALT6/NEU1/CERS2/PSAPL1/HEXA/SGMS1/SPTLC1/GLA/CERS3/DEGS2/ASAH1/SGPP1	18
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	41/4078	109/8135	0.9969	1	0.6965	BMS1/TCOF1/NAT10/REXO1/CSNK2A2/NXT2/LSG1/UTP18/DROSHA/EMG1/RIOK2/NMD3/NOL6/SPATA5/XRN1/GNL3L/MDN1/POP4/CSNK2A1/NOP10/RCL1/UTP15/IMP4/NOB1/GAR1/IMP3/AK6/RPP40/EIF6/FBLL1/XRN2/WDR3/GTPBP4/POP7/NXF3/UTP6/RPP25L/NHP2/POP5/REXO2/RRP7A	41
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	7/4078	27/8135	0.9972	1	0.6965	ELOVL5/HSD17B4/BAAT/ELOVL7/SCD/ELOVL2/ACOX1	7
KEGG	hsa04613	Neutrophil extracellular trap formation	71/4078	190/8135	0.9999	1	0.6965	ITGAL/HDAC10/PIK3CA/HDAC1/MAP2K2/HAT1/CASP1/CLEC7A/NFKB1/CLCN5/MTOR/PLCG1/AKT1/AKT2/RAC2/HDAC7/FCGR1A/PIK3R2/HDAC3/PRKCB/C5AR1/ACTB/SLC25A4/MAPK14/C5/PIK3R1/GP1BA/PIK3CB/PLCB3/VDAC2/TLR4/ELANE/AZU1/GSDMD/HMGB1/PADI4/SRC/FGB/SLC25A6/CASP4/HDAC4/SIGLEC9/HDAC6/CAMP/TLR7/VWF/SELPLG/ATG7/HDAC5/PLCB1/PPIF/CLCN4/FGG/FCGR2A/HDAC11/HDAC2/AQP9/MAPK13/HDAC8/MAPK1/FPR3/PRKCG/MAPK12/VDAC1/SLC25A31/AGER/AKT3/MPO/MAP3K7/MAP2K1/FCGR3B	71
KEGG	hsa05034	Alcoholism	66/4078	187/8135	1	1	0.6965	HDAC10/HDAC1/HAT1/GNAI2/GNB4/GNG2/GNGT2/CREB1/CAMKK2/GNG10/GNB1/CALML4/NRAS/ATF2/GRIN3B/ARAF/HDAC7/SOS1/KRAS/GRIN2C/GNB5/HDAC3/CRH/PRKACB/CREB3L2/GRB2/NPY/PPP1CB/PRKACG/GNG5/GNB2/PPP1CA/GNB3/HRAS/GNAS/SLC29A2/GRIN2B/SLC29A1/PRKACA/GNAI3/CALML5/BRAF/DDC/PDYN/GNG4/HDAC4/HDAC6/SOS2/DRD2/CAMKK1/HDAC5/SHC3/ADORA2B/CALM1/GRIN2D/GRIN2A/HDAC11/HDAC2/CREB3/HDAC8/MAPK1/SHC1/PKIA/ATF4/MAP2K1/GNGT1	66
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	15/4078	66/8135	1	1	0.6965	AARS2/CARS2/EARS2/HARS2/FARSB/YARS2/IARS2/MTFMT/GATC/LARS2/FARS2/FARSA/PSTK/QRSL1/SEPSECS	15
KEGG	hsa05206	MicroRNAs in cancer	105/4078	310/8135	1	1	0.6965	DNMT3A/PIK3CA/PTGS2/CASP3/HDAC1/MAP2K2/BMPR2/UBE2I/MCL1/DNMT1/NFKB1/MDM4/MTOR/NRAS/PDGFB/ATM/DICER1/MYC/PLCG1/APC2/MIRLET7D/CYP24A1/CDC25B/BCL2/SOS1/CCND1/PIK3R2/KRAS/TP53/PRKCB/TNXB/GRB2/HMOX1/PIK3R1/IGF2BP1/ABCB1/CCND2/TNC/RASSF1/E2F3/EP300/PIK3CB/EZR/RPTOR/SOCS1/HRAS/MDM2/HNRNPK/BAK1/CRK/EFNA5/VIM/ZEB2/BRCA1/FSCN1/IKBKB/SOX4/CDC25C/EFNA1/TPM1/ABL1/ROCK1/SIRT1/FOXP1/PDGFRA/CDK6/HDAC4/PIM1/GLS/NOTCH4/ITGA5/SOS2/BCL2L11/EFNA4/HDAC5/CCNE2/CCNE1/BMF/RDX/ST14/TNR/EGFR/MARCKS/ERBB3/EZH2/HDAC2/PDCD4/RECK/MAPK1/PRKCG/RPS6KA5/CDKN2A/TP63/MIR194-2/TIMP3/SHC1/PDGFRB/TRIM71/CDKN1A/CYP1B1/MIR34A/NOTCH3/CD44/MAP2K1/PDGFA	105
KEGG	hsa05322	Systemic lupus erythematosus	25/4078	136/8135	1	1	0.6965	C1QA/SNRPD1/TNF/TRIM21/FCGR1A/CD86/CD28/C1QB/C1QC/IFNG/C5/HLA-DRA/C7/ELANE/GRIN2B/ACTN4/C1S/HLA-DMB/FCGR2A/GRIN2A/HLA-DOB/C8G/HLA-DPB1/CD40LG/FCGR3B	25
KEGG	hsa04740	Olfactory transduction	56/4078	440/8135	1	1	0.6965	ARRB2/GNB1/CALML4/OR2F1/OR10H1/ARRB1/SLC24A4/PRKACB/GUCY2D/PRKACG/PDE1A/RGS2/OR5H1/PRKACA/CALML5/OR1A2/SLC8A1/OR7C1/OR52A1/OR5P3/CAMK2B/OR2H2/CAMK2A/OR2J3/OR10A4/OR3A2/OR2C1/OR2A4/OR10H2/OR51B2/OR4D1/OR7C2/OR8G1/OR2L13/OR5P2/OR51I2/OR3A3/OR2B6/CALM1/OR1E1/PDE1B/OR10D3/OR5V1/OR11A1/OR10H3/ADCY3/OR1J4/OR2S2/CAMK2G/SLC8A2/OR5I1/OR2B2/OR1J2/OR5K1/OR2F2/OR6A2	56