ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05417	Lipid and atherosclerosis	187/5985	215/8135	1.058e-06	0.0003493	0.0002389	TP53/CYP2A7/RXRB/HRAS/IFNA10/KRAS/IFNA16/NFKBIA/IFNA14/JUN/HSPD1/AKT2/IFNA17/MIB2/TRAF6/GSK3B/CYBA/PPP3CC/TLR6/SELP/NOS3/MMP9/NRAS/CYP1A1/IRAK4/PLCB3/MAP3K5/TNFSF10/IFNA13/PDPK1/HSPA1L/PYCARD/ATF6/NCF1/TICAM2/CD36/HSP90AB1/IRF3/CD14/HSPA1A/HSPA1B/CYP2B6/TLR2/MYD88/CALM2/CALM3/NFE2L2/MAPK8/TAB1/TNFRSF10B/CYP2C9/HSPA6/MAP3K7/MAP2K3/RXRA/NOX1/NCF4/TNFRSF1A/XBP1/IFNA4/CASP6/APOA4/CALML5/MAP2K4/CHUK/NCF2/PTK2/CALML4/MAPK9/ROCK2/PIK3CB/BID/IFNA7/IRF7/IKBKG/FASLG/CAMK2G/CASP9/CYP2J2/ARHGEF1/PPP3CA/LYN/CALML3/APOA1/CALML6/TLR4/RAC1/AGER/PRKCA/CALM1/CDC42/HSP90B1/SELE/SRC/VAV1/BAX/APAF1/LDLR/BAD/CD40/AKT3/HSPA4/ABCG1/VLDLR/CD40LG/NFATC2/IFNA1/CCL5/RAP1A/IL18/PIK3CD/PLCB4/BCL2/CASP1/RHOA/CCL2/CXCL1/IKBKE/PIK3R3/CXCL2/TIRAP/IFNA5/CYP2A6/POU2F3/ATF4/ABCA1/TRAF2/PPARG/CXCL3/IL1B/ERN1/HSP90AA1/TICAM1/PPP3CB/IFNA8/FOS/RAP1B/LY96/IFNA6/TRAF3/VAV2/CAMK2D/EIF2S1/LBP/IFNA21/PLCB2/CYP2C8/PIK3R2/STAT3/VAV3/TAB2/MMP1/JAK2/DDIT3/IFNA2/ITPR1/CXCL8/SOD2/EIF2AK3/MAPK1/PIK3CA/AKT1/IRAK1/TANK/OLR1/MAPK3/CCL3/CCL3L1/CCL3L3/MAPK14/HSPA8/MMP3/POU2F1/TNFRSF10A/MAP2K7/MAPK13/MIB1/PPP3R1/FAS/HSPA5/HSPA2/NFKB1/IL6/PLCB1/IL12A/CAMK2B/BCL2L1	187
KEGG	hsa05152	Tuberculosis	158/5985	180/8135	2.091e-06	0.0003493	0.0002389	RAB7A/CD74/IFNA10/MRC2/IFNA16/RAB5C/IFNA14/RAB5A/HSPD1/JAK1/TRADD/AKT2/IL10RB/IFNA17/TRAF6/LAMP2/LAMP1/FADD/RAF1/PPP3CC/ATP6V0C/TLR6/RFXANK/NFYA/KSR1/ATP6V0D2/IRAK4/CLEC4E/IFNA13/ATP6V0B/CTSS/NFYB/TLR1/SPHK1/CAMP/NOD2/CD14/SPHK2/FCGR3B/TLR2/MYD88/CALM2/CALM3/CEBPB/MAPK8/CR1L/IFNGR2/HSPA9/ARHGEF12/CREBBP/TNFRSF1A/IFNA4/SYK/ATP6V1H/CALML5/LSP1/CALML4/FCGR2B/MAPK9/EEA1/BID/HLA-DPA1/IFNA7/IFNGR1/CAMK2G/CASP9/ATP6V0D1/PPP3CA/CALML3/CALML6/TLR4/PIK3C3/CALM1/HLA-DMB/SRC/NFYC/ATP6AP1/BAX/APAF1/CORO1A/BAD/FCGR3A/HLA-DRB1/CYP27B1/CD209/AKT3/IRAK2/HLA-DQA2/CR1/HLA-DRA/PLK3/HLA-DMA/VDR/CREB1/IFNA1/FCER1G/CIITA/IL18/BCL2/NOS2/RHOA/MRC1/HLA-DQB1/TGFB1/EP300/IL10/TIRAP/MALT1/IFNA5/ITGAM/ITGB2/STAT1/HLA-DOB/CLEC4M/HLA-DRB4/CASP10/IL23A/IFNG/IL1B/CEBPG/TLR9/PPP3CB/HLA-DOA/IFNA8/RIPK2/CARD9/IFNA6/CTSD/RFXAP/FCGR1A/CAMK2D/LBP/HLA-DPB1/IFNA21/JAK2/IFNA2/IL10RA/MAPK1/CLEC7A/AKT1/FCGR2A/IRAK1/RFX5/MAPK3/PLA2R1/MAPK14/ATP6V0A1/HLA-DQA1/IL1A/TGFB3/LOC102723407/MAPK13/PPP3R1/NFKB1/IL6/IL12A/CAMK2B/TCIRG1	158
KEGG	hsa04060	Cytokine-cytokine receptor interaction	248/5985	295/8135	8.715e-06	0.0009702	0.0006635	IL2RG/CTF1/PF4V1/PF4/IFNA10/IFNA16/BMP8B/PPBP/CXCL5/ACVR2A/IFNA14/TNFSF4/CXCR2/IL17C/INHBC/BMP15/IL10RB/IFNA17/CCL27/TNFRSF4/CXCR1/CCR3/CCL16/GH2/TNFRSF11B/CX3CL1/ACVR1/TNFSF15/LTB/CCL14/IL6R/CCR2/CNTF/CSF2RB/GDF10/TNFSF10/IFNLR1/CSF2/IFNA13/IL1R2/CX3CR1/CCL24/TNFRSF10C/CSF2RA/TNFSF14/GDF1/IL12RB1/PRL/ACKR4/TNFSF13B/IL6ST/LIF/IL3/TNFRSF10B/IFNGR2/EDAR/CLCF1/CCR1/TNFRSF1A/IL17RA/IL17B/IFNA4/CSF3R/TNFSF13/IL1RL1/ACKR3/CCR5/CXCR4/IL13RA1/IL5/IFNK/IFNA7/IL22RA1/IL16/ACVR1C/IL27RA/IFNGR1/FASLG/GH1/INHA/EDA2R/CXCL12/IL1F10/IFNAR1/IL17RE/CCR7/CD27/CCL21/AMH/TNFSF9/TNFRSF12A/IL24/IL20RB/GDF9/CSF3/NGF/CNTFR/IL11/BMP8A/IL18RAP/AMHR2/IL4/GDF3/TGFBR1/CD40/CXCL10/IL36RN/IFNW1/CD70/BMP3/IL21/EPO/CSH2/IL19/CCL8/IL23R/OSM/CD40LG/IFNA1/IL37/IL31RA/CCL5/TNFRSF1B/IL18/IFNE/CCL17/IL20/CCL28/IL20RA/IL1RAP/GDF11/CCR9/LEPR/CCL2/TGFBR2/IL2/CXCL1/EBI3/IL13RA2/IL17D/TNFSF8/RELT/TNFRSF17/TGFB1/CCL25/IL7R/EPOR/IL10/CXCL2/IL1RN/INHBE/IL11RA/IFNA5/IL1R1/CXCL9/BMP5/CCR6/IL17RB/CXCR6/CCL20/CXCL3/IL23A/IFNG/BMP4/IL17A/IL1B/CSF1/IL17RC/IL26/TNFRSF19/IFNL2/IL2RB/INHBA/IL18R1/IFNA8/TNFRSF8/XCL1/IFNL3/IFNA6/ACVRL1/IL25/IL17F/TNFRSF6B/CCL13/TNFRSF13B/IL21R/TNFRSF11A/IL4R/LTA/TSLP/TNFRSF18/IL3RA/IFNL1/IFNA21/XCL2/ACVR1B/CCR10/BMP6/IL34/BMPR1B/CCL1/CCL18/CXCL14/GDF5/CCR4/IFNA2/IL10RA/IL5RA/CXCL8/TNFRSF14/IL15/IFNAR2/CSF1R/CCL26/BMP10/NGFR/IL27/IL2RA/XCR1/OSMR/IL15RA/IL1RL2/CCL3/CCL3L1/CCL3L3/ACVR2B/TNFSF11/CCL22/CCR8/CXCL6/TNFRSF9/TNFRSF21/GDF15/IL1A/IL12RB2/TNFRSF10A/IL36A/CCL23/TGFB3/IL9/FAS/CXCR5/CCL4/IL9R/IL6/IL12A/IL32/IL36B	248
KEGG	hsa05320	Autoimmune thyroid disease	51/5985	53/8135	1.63e-05	0.001317	0.0009006	IFNA10/IFNA16/IFNA14/IFNA17/HLA-C/HLA-G/TPO/CGA/HLA-E/IFNA13/HLA-A/HLA-B/IFNA4/HLA-F/IL5/CD80/HLA-DPA1/IFNA7/FASLG/HLA-DMB/GZMB/IL4/HLA-DRB1/CD40/HLA-DQA2/HLA-DRA/CD86/HLA-DMA/CD40LG/IFNA1/HLA-DQB1/IL2/IL10/IFNA5/HLA-DOB/HLA-DRB4/HLA-DOA/IFNA8/PRF1/TSHB/CTLA4/IFNA6/HLA-DPB1/IFNA21/IFNA2/TSHR/HLA-DQA1/LOC102723407/FAS/CD28/TG	51
KEGG	hsa04151	PI3K-Akt signaling pathway	293/5985	354/8135	1.971e-05	0.001317	0.0009006	YWHAE/TP53/PKN1/IL2RG/PPP2R1A/ATF6B/GNG2/PIK3R5/MCL1/JAK3/HRAS/PPP2R3C/MDM2/IFNA10/ATF2/EGFR/KRAS/LAMB1/IFNA16/IFNA14/GNG11/GNG4/CHRM2/CDK6/ITGB1/COL1A1/TNN/RHEB/ITGB5/JAK1/PPP2R2D/AKT2/IFNA17/YWHAB/GSK3B/EGF/YWHAG/ITGA4/GH2/TCL1A/EIF4B/FGF8/ANGPT2/NTF4/AREG/RAF1/TCL1B/CREB5/CDKN1B/DDIT4/CD19/VWF/NOS3/EFNA1/NRAS/FGFR4/RPS6KB2/EIF4E/IL6R/SOS2/C8orf44-SGK3/SGK3/FGFR3/PPP2R5B/FGF3/BRCA1/IFNA13/NTF3/MTOR/TEK/PDPK1/PHLPP2/BCL2L11/FLT4/GNB2/CREB3L3/COMP/HSP90AB1/PRL/FGF4/ITGB3/ITGA10/TLR2/PPP2R1B/COL6A3/IL3/ITGA9/RPS6KB1/CCND2/GNG5/CREB3/ITGA5/PPP2CA/RXRA/CCNE2/IFNA4/CSF3R/CREB3L4/SYK/GNG10/COL2A1/PDGFA/ANGPT1/CHUK/PTK2/COL1A2/ITGB4/COL4A1/FGF23/IRS1/ITGA11/IGF1R/PIK3CB/IFNA7/COL6A1/GNGT1/TSC1/RELN/IKBKG/NTRK1/FGF16/FASLG/VTN/GH1/CASP9/ERBB2/IFNAR1/LAMC1/INS/GNG7/STK11/TLR4/RAC1/ITGA2B/COL4A2/FLT1/PRKCA/CSF3/MET/HSP90B1/FGF9/NGF/FGF18/GNG8/PDGFC/SGK2/FGF19/FGF20/IL4/FGFR1/ITGB6/RPTOR/TSC2/CHAD/BAD/GRB2/AKT3/KIT/LPAR1/EIF4EBP1/PHLPP1/FLT3LG/TGFA/CDK4/EPO/THBS4/CSH2/CREB1/OSM/IFNA1/PDGFRA/F2R/FGF1/THBS2/LAMB2/PIK3CD/TNR/G6PC2/PPP2R5C/GNG13/HGF/CHRM1/FGF2/BCL2/PPP2R3A/FGF22/ANGPT4/LPAR5/PKN3/MAP2K2/IL2/LPAR2/G6PC3/LAMB3/PIK3R3/IL7R/EPOR/PPP2R2C/CDK2/LAMA2/IFNA5/PTEN/PKN2/COL6A2/YWHAQ/EFNA3/PPP2R5D/ATF4/KITLG/EPHA2/IBSP/BDNF/GNG3/NTRK2/PPP2R2A/FGF21/HSP90AA1/CSF1/IL2RB/IFNA8/PPP2R3B/GYS1/PGF/PDGFD/IFNA6/PCK2/RBL2/YWHAH/FN1/IL4R/GYS2/IL3RA/CREB3L1/IFNA21/LAMA5/ITGA1/MAGI1/PIK3R2/EREG/COL9A2/FGF17/VEGFC/JAK2/IFNA2/PIK3CG/ERBB4/PIK3R6/MAPK1/PIK3CA/AKT1/ERBB3/IFNAR2/CSF1R/PIK3AP1/GNG12/CDKN1A/NGFR/IL2RA/MAPK3/ITGA2/OSMR/THBS3/SPP1/SGK1/FGF5/LPAR6/PRKAA1/MAP2K1/THBS1/LAMC2/LAMC3/MYB/NR4A1/LOC102723407/CCNE1/MTCP1/FOXO3/SOS1/NFKB1/GNB4/ITGA3/ITGA8/ITGA6/IL6/FLT3/MLST8/G6PC/YWHAZ/LPAR4/EFNA4/VEGFB/BCL2L1/PPP2R5A	293
KEGG	hsa04621	NOD-like receptor signaling pathway	158/5985	184/8135	3.689e-05	0.002054	0.001405	YWHAE/PKN1/NFKBIB/IFNA10/IFNA16/NFKBIA/ATG16L1/IFNA14/JUN/JAK1/RNASEL/IFNA17/NLRP12/TRAF6/GBP1/CYBA/FADD/GABARAPL2/ITPR2/TRPV2/ATG5/GPRC6A/DEFA1/DEFA1B/DEFA3/NLRP6/XIAP/TXN/IRAK4/PLCB3/IFNA13/MEFV/PYCARD/TP53BP1/CARD6/MAP1LC3B/CAMP/HSP90AB1/DEFB4A/DEFB4B/NOD2/IRF3/SHARPIN/MYD88/NLRX1/IFI16/TNFAIP3/MAPK8/DEFA6/CASR/TAB1/GBP3/CTSB/MAP3K7/DEFB103A/DEFB103B/GABARAPL1/NAMPT/IFNA4/MAVS/CHUK/TXN2/GABARAP/MAPK9/IFNA7/IRF7/GBP2/IKBKG/DNM1L/STAT2/TAB3/PSTPIP1/MAP1LC3A/GBP4/ATG12/IFNAR1/CASP4/TLR4/SUGT1/MFN2/PRKCD/DEFA4/PYDC1/RNF31/CASP5/RIPK3/MAP1LC3C/NAIP/CARD18/OAS1/TRPM7/MFN1/RBCK1/DHX33/IFNA1/CCL5/IL18/PLCB4/BCL2/P2RX7/CASP1/RHOA/VDAC1/CCL2/CXCL1/TXNIP/AIM2/IKBKE/CXCL2/IFNA5/PKN2/STAT1/TRAF2/MAP1LC3B2/CXCL3/ITPR3/IL1B/HSP90AA1/TICAM1/TYK2/IFNA8/TRPM2/RIPK2/CARD9/CASP12/NOD1/IFNA6/TRAF3/IFNA21/PLCB2/GSDMD/NEK7/TAB2/ANTXR2/IFNA2/ITPR1/CXCL8/DEFA5/MAPK1/IFNAR2/TANK/MAPK3/OAS3/MAPK14/VDAC2/IRF9/ANTXR1/NLRC4/MAPK13/BRCC3/OAS2/NFKB1/IL6/MCU/PLCB1/VDAC3/BCL2L1/BIRC3	158
KEGG	hsa04142	Lysosome	116/5985	132/8135	4.327e-05	0.002065	0.001412	AP4B1/GNPTAB/NPC1/DNASE2/CTSE/ENTPD4/CLTC/AP4E1/AP1G1/HGSNAT/IDUA/LAMP2/IDS/LAMP1/CLTA/ATP6V0C/GGA3/PPT1/SUMF1/ATP6V0D2/LITAF/AP1G2/GUSB/IGF2R/GNPTG/ABCA2/ATP6V0B/CTSS/SLC17A5/AP1M2/LAMP3/HYAL2/CTSA/CTSO/CTSB/CD68/PSAPL1/GBA/AP3M1/CTNS/AP4M1/ATP6V1H/GGA2/NAGLU/AP3D1/SGSH/AP3B1/DMXL2/NPC2/PSAP/ATP6V0D1/MCOLN1/GLA/NAGPA/NEU1/TPP1/SMPD1/LAPTM4B/ATP6AP1/DMXL1/ASAH1/LAPTM5/GLB1/LGMN/GNS/HEXB/AP1S3/LIPA/CTSG/CTSH/CTSK/LAPTM4A/SLC11A2/ACP2/AP1B1/NAGA/CLN3/AP3S2/HYAL4/CTSC/AP3S1/ARSG/MANBA/MFSD8/GM2A/DNASE2B/AP1S2/WDR7/AP3B2/SORT1/CTSD/MAN2B1/AP1S1/AP4S1/AP3M2/ABCB9/SPAM1/ACP5/CTSV/CD63/CTSL/GALNS/GALC/NAPSA/M6PR/AGA/ATP6V0A1/GAA/HEXA/CLTCL1/PLA2G15/HYAL1/SLC11A1/AP1M1/FUCA2/TCIRG1	116
KEGG	hsa05323	Rheumatoid arthritis	84/5985	93/8135	4.954e-05	0.002068	0.001415	CXCL5/JUN/ATP6V1B2/ATP6V0C/ATP6V0E1/LTB/ATP6V0D2/CSF2/TEK/ATP6V0B/TNFSF13B/ATP6V1C2/TLR2/ATP6V1G3/TNFSF13/ATP6V1H/ANGPT1/CD80/HLA-DPA1/ATP6V0D1/ATP6V1E1/CXCL12/ATP6V1E2/ATP6V1A/TLR4/ATP6V1F/FLT1/ATP6V1C1/HLA-DMB/IL11/ATP6AP1/HLA-DRB1/HLA-DQA2/ATP6V1B1/HLA-DRA/CD86/HLA-DMA/CCL5/IL18/CTSK/ITGAL/HLA-DQB1/CCL2/CXCL1/TGFB1/CXCL2/ITGB2/HLA-DOB/HLA-DRB4/CCL20/CXCL3/IL23A/IFNG/IL17A/IL1B/CSF1/HLA-DOA/FOS/CTLA4/TNFRSF11A/HLA-DPB1/ACP5/MMP1/ATP6V0E2/CTSL/CXCL8/IL15/CCL3/CCL3L1/CCL3L3/TNFSF11/ATP6V0A1/CXCL6/HLA-DQA1/IL1A/MMP3/ATP6V1G2/TGFB3/ATP6V1D/LOC102723407/ATP6V1G1/CD28/IL6/TCIRG1	84
KEGG	hsa04810	Regulation of actin cytoskeleton	184/5985	218/8135	7.922e-05	0.002688	0.001839	PFN1/CFL1/BRK1/HRAS/ARAF/MYL12A/ARPC1B/PIP5K1A/EGFR/KRAS/FGD3/PIKFYVE/ARPC4/MSN/MYH11/BRAF/CHRM2/MYH10/MYLK4/ITGB1/PPP1CC/ITGB5/MYLK3/ACTG1/EZR/EGF/ARHGAP35/ITGA4/FGF8/GIT1/PPP1CB/ARHGEF7/RAF1/ACTR3/ACTB/NRAS/FGFR4/SOS2/FGFR3/DIAPH1/FGF3/RDX/ACTN4/ARPC1A/ACTR2/FGF4/ITGB3/ITGA10/CYFIP1/PAK4/ROCK1/ITGA9/LIMK1/ITGA5/ACTN1/ARHGEF12/MYH9/IQGAP2/CFL2/GNA13/PPP1R12C/ARPC5L/MYLK/PIP4K2B/PDGFA/CXCR4/TMSB4X/PTK2/ITGB4/FGF23/ITGA11/ROCK2/CRK/PIK3CB/FGF16/ARHGEF4/ARHGEF1/CXCL12/PAK2/MYH14/PIP5K1C/INS/NCKAP1L/APC/RAC1/ITGA2B/APC2/PAK1/CDC42/FGF9/SRC/VAV1/FGF18/PDGFC/FGF19/FGF20/PFN2/FGFR1/IQGAP1/ITGB6/KNG1/SPATA13/LPAR1/ARPC2/GNA12/PDGFRA/F2R/FGF1/WASL/PIK3CD/CHRM5/PIP5K1B/CHRM1/FGF2/RHOA/F2/RAC3/FGF22/ITGAL/PAK3/LPAR5/MAP2K2/LPAR2/INSRR/PIK3R3/MYL7/WASF1/MYL9/SSH2/ITGAM/SCIN/ITGB2/GSN/LIMK2/FGF21/IQGAP3/RAC2/CHRM4/PPP1CA/DIAPH2/WASF2/PDGFD/ITGAD/SSH1/PXN/ITGAE/MYLK2/VAV2/MYLPF/CHRM3/FN1/PPP1R12B/SLC9A1/MOS/ITGA1/PIK3R2/MYL5/PIP4K2A/VAV3/FGF17/MYL12B/MAPK1/CYFIP2/PIK3CA/SSH3/GNG12/MAPK3/ITGA2/FGF5/BCAR1/MAP2K1/ENAH/NCKAP1/ARPC3/PAK6/TIAM1/SOS1/ITGA3/ITGA8/ITGA6/TMSB4Y/BDKRB1/VCL/LPAR4	184
KEGG	hsa05162	Measles	121/5985	139/8135	8.049e-05	0.002688	0.001839	TP53/IL2RG/NFKBIB/JAK3/IFNA10/IFNA16/NFKBIA/IFNA14/MSN/CD46/JUN/RAB9B/CDK6/JAK1/TRADD/AKT2/IFNA17/TRAF6/GSK3B/FADD/CDKN1B/IRAK4/CSNK2A1/IFNA13/HSPA1L/CSNK2B/IRF3/HSPA1A/HSPA1B/RCHY1/MX2/TLR2/MYD88/TNFAIP3/MAPK8/CCND2/STAT5B/HSPA6/MAP3K7/CCNE2/IFNA4/MAVS/CHUK/MX1/FCGR2B/IFIH1/MAPK9/PIK3CB/BID/IFNA7/IRF7/IKBKG/FASLG/STAT2/CASP9/IFNAR1/TLR7/TLR4/RAB9A/ADAR/BAX/APAF1/EIF2AK1/BAD/OAS1/CD209/AKT3/CDK4/STAT5A/IFNA1/PIK3CD/SLAMF1/BCL2/IL2/IKBKE/PIK3R3/CDK2/IFNA5/STAT1/TP73/EIF2AK4/CLEC4M/IL1B/TLR9/IL2RB/TYK2/IFNA8/FOS/IFNA6/TRAF3/EIF2S1/EIF2AK2/IFNA21/PIK3R2/STAT3/TAB2/IFNA2/DDX58/EIF2AK3/PIK3CA/AKT1/IFNAR2/IRAK1/IL2RA/OAS3/CSNK2A2/IRF9/HSPA8/IL1A/BAK1/CCNE1/CBLB/FAS/HSPA2/OAS2/NFKB1/CD3G/CD28/IL6/IL12A/BCL2L1	121
KEGG	hsa04915	Estrogen signaling pathway	120/5985	138/8135	9.603e-05	0.002736	0.001871	ATF6B/NCOA2/HRAS/SHC1/ATF2/EGFR/KRAS/JUN/KRT23/MMP2/AKT2/SP1/ITPR2/ADCY6/RAF1/CREB5/NOS3/MMP9/NRAS/SOS2/KRT38/KRT10/PLCB3/ADCY7/GRM1/HSPA1L/KRT31/ESR2/KRT37/CREB3L3/HSP90AB1/HSPA1A/HSPA1B/CALM2/CALM3/KRT19/KRT15/CREB3/HSPA6/KCNJ6/GABBR1/KRT33B/KRT9/KRT32/CREB3L4/KRT14/CALML5/KRT34/LOC100653049/GPER1/CALML4/PIK3CB/KCNJ9/KRT33A/CALML3/CALML6/ADCY9/ADCY8/CALM1/GABBR2/PRKCD/HSP90B1/SRC/PRKACA/FKBP4/NCOA1/KRT40/GRB2/AKT3/POMC/KRT13/KRT16/TGFA/KRT24/CREB1/PIK3CD/NCOA3/ESR1/PLCB4/BCL2/MAP2K2/KCNJ3/PIK3R3/SHC3/PGR/OPRM1/ATF4/KRT35/GNAQ/ITPR3/HSP90AA1/FOS/TFF1/CTSD/ADCY5/GNAI2/PRKACB/CREB3L1/PLCB2/GNAI3/PIK3R2/RARA/ITPR1/KRT12/MAPK1/PIK3CA/AKT1/KRT27/MAPK3/GNAO1/MAP2K1/HSPA8/SHC2/ADCY3/KRT25/HSPA2/SOS1/KRT20/PLCB1/PRKACG	120
KEGG	hsa05130	Pathogenic Escherichia coli infection	167/5985	197/8135	0.0001038	0.002736	0.001871	NFKBIB/BRK1/CYTH1/PTPN11/TUBB1/ARPC1B/NFKBIA/ARPC4/MYH11/MYO1C/JUN/CLDN7/MYH10/ITGB1/TRADD/CLDN17/ACTG1/EZR/TRAF6/CLDN15/TMBIM6/FADD/BAIAP2L1/CTTN/MYO1H/ARHGEF2/ACTR3/ACTB/CLDN3/CYTH4/CLDN20/CLDN19/IRAK4/WIPF2/TNFSF10/ARPC1A/ARF6/PYCARD/CYTH3/MYO5C/ACTR2/MYD88/CLDN8/CYFIP1/MAPK8/TAB1/SEC24D/ROCK1/WASF3/TNFRSF10B/MAP3K7/ARHGEF12/MYH9/TNFRSF1A/GNA13/ARPC5L/TUBA1C/CHUK/MAPK9/RAB1A/ROCK2/IKBKG/CLDN5/MYO1D/FASLG/NCL/TAB3/ABCF2/GAPDH/CASP9/TUBA1A/ARHGEF1/PAK2/MYO1F/CLDN1/MYH14/NCKAP1L/CASP4/TLR4/RAC1/PAK1/CLDN4/CDC42/TUBA1B/TLR5/SRC/BAX/ABI1/SLC9A3R1/NAIP/LPAR1/ARPC2/GNA12/CLDN14/F2R/WASL/IL18/TUBA3C/TUBA3D/CLDN16/TUBB6/CASP1/RHOA/F2/HCLS1/PAK3/LPAR5/LPAR2/TIRAP/WASF1/TUBB2A/IL1R1/CLDN11/CLDN10/MYO1G/TRAF2/IL1B/CYTH2/TUBA4A/MYO5A/FYN/FOS/WASF2/OCLN/ARF1/CLDN18/TJP1/SEC24A/TMED10/RPS3/TUBB4A/TAB2/CXCL8/TUBB3/MYO1E/MAPK1/CYFIP2/FCGR2A/MYO6/IRAK1/MYO1B/MAPK3/TUBB4B/MYO1A/ABL1/MAPK14/SEC24B/CLDN23/MYO5B/TUBA8/NCKAP1/ARPC3/TNFRSF10A/BAK1/NLRP4/TUBB/LOC102723407/MAPK13/FAS/TUBAL3/NFKB1/PTPN6/WIPF3/IL6/CLDN9/WIPF1/LPAR4	167
KEGG	hsa04062	Chemokine signaling pathway	163/5985	192/8135	0.0001065	0.002736	0.001871	NFKBIB/GNG2/PIK3R5/JAK3/HRAS/SHC1/PF4V1/PF4/KRAS/PPBP/NFKBIA/CXCL5/PTK2B/GNG11/GNG4/BRAF/CXCR2/RASGRP2/AKT2/CCL27/GSK3B/CXCR1/CCR3/CCL16/ADCY6/RAF1/GRK7/CX3CL1/NRAS/CCL14/SOS2/CCR2/PLCB3/ADCY7/CX3CR1/CCL24/NCF1/GNB2/ROCK1/PREX1/GNG5/STAT5B/CCR1/HCK/GNG10/GSK3A/CCR5/CXCR4/CHUK/PTK2/ROCK2/CRK/PIK3CB/GNGT1/GRK6/IKBKG/STAT2/PARD3/CXCL12/LYN/CCR7/GNG7/CCL21/ADCY9/PRKCZ/RAC1/ADCY8/GRK1/PAK1/CDC42/PRKCD/SRC/VAV1/GNG8/PRKACA/BAD/GRB2/AKT3/CXCL10/CCL8/CCL5/RAP1A/PIK3CD/CCL17/CCL28/GNG13/PLCB4/RHOA/RAC3/CCR9/CCL2/CXCL1/CCL25/PIK3R3/CXCL2/SHC3/DOCK2/CXCL9/CCR6/FGR/STAT1/GNAQ/PLCG2/CXCR6/CCL20/CXCL3/GNG3/ITK/RAC2/RAP1B/GRK5/XCL1/PXN/ADCY5/CCL13/VAV2/GNAI2/PRKACB/PLCB2/XCL2/CCR10/GNAI3/PIK3R2/CCL1/STAT3/VAV3/CCL18/ARRB2/CXCL14/JAK2/CCR4/PIK3CG/CXCL8/WAS/PIK3R6/MAPK1/PIK3CA/AKT1/CCL26/GNG12/XCR1/MAPK3/CCL3/CCL3L1/CCL3L3/BCAR1/CCL22/CCR8/MAP2K1/CXCL6/CCL23/SHC2/TIAM1/ADCY3/FOXO3/CXCR5/SOS1/NFKB1/GNB4/ARRB1/CCL4/PLCB1/PRKACG	163
KEGG	hsa04145	Phagosome	131/5985	152/8135	0.0001181	0.002818	0.001927	RAB7A/TUBB1/MRC2/RAB5C/PIKFYVE/DYNC1H1/RAB5A/RILP/ITGB1/ITGB5/HLA-C/ACTG1/HLA-G/LAMP2/CYBA/LAMP1/ATP6V1B2/SEC22B/ATP6V0C/TLR6/ATP6V0E1/ACTB/ATP6V0D2/SEC61A2/HLA-E/ATP6V0B/CTSS/NCF1/COMP/CD36/CALR/CD14/HLA-A/ITGB3/ATP6V1C2/FCGR3B/TLR2/CANX/TFRC/ITGA5/HLA-B/NCF4/ATP6V1G3/SEC61G/TUBA1C/ATP6V1H/TAP2/HLA-F/NCF2/FCGR2B/STX12/EEA1/HLA-DPA1/COLEC12/NOS1/SCARB1/ATP6V0D1/TUBA1A/ATP6V1E1/ATP6V1E2/ATP6V1A/TLR4/RAC1/ATP6V1F/TAP1/PIK3C3/ATP6V1C1/TUBA1B/HLA-DMB/ATP6AP1/CORO1A/FCGR3A/HLA-DRB1/CD209/HLA-DQA2/ATP6V1B1/HLA-DRA/HLA-DMA/THBS4/SEC61A1/THBS2/TUBA3C/TUBA3D/TUBB6/MRC1/HLA-DQB1/TUBB2A/DYNC1I2/STX18/ITGAM/ITGB2/HLA-DOB/RAB7B/CLEC4M/HLA-DRB4/MARCO/TUBA4A/HLA-DOA/DYNC1I1/COLEC11/MBL2/FCGR1A/HLA-DPB1/DYNC1LI1/SEC61B/TUBB4A/ATP6V0E2/CTSL/TUBB3/CLEC7A/FCGR2A/OLR1/TUBB4B/ITGA2/THBS3/PLA2R1/M6PR/ATP6V0A1/TUBA8/HLA-DQA1/THBS1/ATP6V1G2/TUBB/ATP6V1D/LOC102723407/ATP6V1G1/TUBAL3/SFTPD/MSR1/TCIRG1/MPO	131
KEGG	hsa04140	Autophagy - animal	122/5985	141/8135	0.0001381	0.003076	0.002104	DAPK3/RAB7A/HRAS/KRAS/AMBRA1/ATG16L1/PIK3R4/RHEB/AKT2/ATG4D/ATG2B/TRAF6/MTMR14/LAMP2/LAMP1/GABARAPL2/ATG5/RAF1/DDIT4/NRAS/RPS6KB2/SMCR8/NRBF2/MTOR/CFLAR/PDPK1/ATG4C/DEPTOR/MAP1LC3B/BECN1/RRAGA/MAPK8/RPS6KB1/CTSB/MAP3K7/PPP2CA/GABARAPL1/RAB8A/RRAGD/GABARAP/MAPK9/IRS1/ATG16L2/RAB1A/IGF1R/PIK3CB/TSC1/WIPI2/PRAP1/MAP1LC3A/ATG12/INS/SNAP29/STK11/ATG14/PIK3C3/RRAGC/ATG7/PRKCD/ULK1/PRKACA/C9orf72/DAPK2/RPTOR/TSC2/MAP1LC3C/HIF1A/BAD/AKT3/SH3GLB1/SUPT20H/HMGB1/ZFYVE1/ATG13/MTMR3/PIK3CD/BCL2/MTMR4/AKT1S1/MAP2K2/PIK3R3/RAB33B/PTEN/ATG9B/BNIP3/TP53INP2/EIF2AK4/RAB7B/RB1CC1/MAP1LC3B2/IGBP1/ERN1/RAB39B/ATG4A/SQSTM1/CTSD/PRKCQ/EIF2S1/ATG101/PRKACB/PIK3R2/CTSL/ITPR1/EIF2AK3/MAPK1/PIK3CA/AKT1/IRS2/TANK/MAPK3/PRKAA1/MAP2K1/UVRAG/ATG2A/ATG9A/ATG4B/VMP1/ATG10/MLST8/DAPK1/PRKACG/BCL2L1	122
KEGG	hsa05161	Hepatitis B	138/5985	162/8135	0.0002576	0.005378	0.003678	TP53/DDX3X/ATF6B/JAK3/HRAS/ARAF/IFNA10/ATF2/KRAS/IFNA16/NFKBIA/PTK2B/IFNA14/JUN/BRAF/SMAD3/DDB1/JAK1/AKT2/SLC10A1/IFNA17/YWHAB/TRAF6/FADD/RAF1/CREB5/NFATC4/MMP9/NRAS/SOS2/SMAD4/IRAK4/IFNA13/CCNA2/PCNA/TICAM2/CREB3L3/IRF3/TLR2/MYD88/MAPK8/TAB1/CREB3/STAT5B/MAP3K7/MAP2K3/CREBBP/CCNE2/IFNA4/CREB3L4/MAVS/MAP2K4/CHUK/IFIH1/MAPK9/PIK3CB/BID/IFNA7/IRF7/IKBKG/HSPG2/FASLG/STAT2/CASP9/IFNAR1/TLR4/PRKCA/CCNA1/SRC/ATP6AP1/BAX/APAF1/BAD/TGFBR1/GRB2/AKT3/E2F3/CREB1/RB1/STAT5A/NFATC2/IFNA1/PIK3CD/BCL2/MAP2K2/TGFBR2/TGFB1/EP300/IKBKE/PIK3R3/PRKCG/CDK2/TIRAP/IFNA5/EGR2/YWHAQ/STAT1/ATF4/CASP10/DDB2/TICAM1/TYK2/IFNA8/FOS/CASP12/IFNA6/TRAF3/CREB3L1/IFNA21/PIK3R2/STAT3/TAB2/JAK2/IFNA2/DDX58/CXCL8/MAPK1/PIK3CA/AKT1/IRAK1/CDKN1A/MAPK3/STAT4/MAPK14/MAP2K1/EGR3/ELK1/MAP2K7/TGFB3/CCNE1/MAPK13/FAS/BIRC5/SOS1/NFKB1/IL6/VDAC3/YWHAZ	138
KEGG	hsa04919	Thyroid hormone signaling pathway	105/5985	121/8135	0.0003146	0.005809	0.003973	TP53/MED12/NCOA2/RXRB/MED14/HRAS/ATP2A3/MDM2/KRAS/SIN3A/PLN/ATP1B3/MYH6/SLC16A2/RHEB/MYH7/AKT2/ACTG1/SLCO1C1/GSK3B/HDAC3/RAF1/ACTB/NRAS/ATP2A2/THRA/PLCB3/SLC16A10/MTOR/PDPK1/MED17/ITGB3/RXRA/CREBBP/MED24/NCOR1/PIK3CB/CASP9/CTNNB1/ATP1B2/KAT2A/KAT2B/ATP1A3/PRKCA/MED13/SRC/PRKACA/PFKFB2/MED12L/NCOA1/TSC2/HIF1A/BAD/PLCD4/ATP1A1/AKT3/MED16/TBC1D4/PLCE1/PFKM/MED1/PIK3CD/NCOA3/ESR1/PLCB4/PLCD3/DIO2/MAP2K2/EP300/PIK3R3/PRKCG/NOTCH1/STAT1/PLCG2/ATP2A1/BMP4/HDAC2/NOTCH2/FOXO1/RCAN1/ATP1A2/SLC2A1/PRKACB/PLCB2/SLC9A1/PIK3R2/NOTCH4/MAPK1/MED27/PIK3CA/AKT1/MED4/MAPK3/THRB/HDAC1/DIO1/MAP2K1/NOTCH3/WNT4/PFKP/DIO3/MED30/PLCB1/PRKACG/PLCD1	105
KEGG	hsa05165	Human papillomavirus infection	270/5985	331/8135	0.0003178	0.005809	0.003973	TP53/PPP2R1A/HRAS/PPP2R3C/MDM2/IFNA10/DVL3/MPP5/FZD2/LLGL1/EGFR/KRAS/LAMB1/IFNA16/DLG1/IFNA14/PSEN1/CDK6/ITGB1/COL1A1/TNN/RHEB/ITGB5/JAK1/PPP2R2D/TRADD/AKT2/WNT2/IFNA17/MAML1/HLA-C/HLA-G/GSK3B/FADD/EGF/BCAP31/TBP/ATP6V1B2/ITGA4/RAF1/ATP6V0C/ATP6V0E1/PTGER4/CREB5/CDKN1B/VWF/NRAS/RPS6KB2/IRF1/SOS2/ATP6V0D2/PPP2R5B/HLA-E/IFNA13/CCNA2/MTOR/RBPJ/ATP6V0B/CREB3L3/COMP/WNT8A/IRF3/PKM/OASL/HLA-A/ITGB3/ITGA10/ATP6V1C2/MX2/PPP2R1B/COL6A3/ITGA9/RPS6KB1/CCND2/CREB3/ITGA5/HLA-B/PPP2CA/CREBBP/CCNE2/ATP6V1G3/TNFRSF1A/IFNA4/CREB3L4/WNT1/RBL1/ATP6V1H/HLA-F/COL2A1/CHUK/MX1/PTK2/COL1A2/ITGB4/COL4A1/RFNG/ITGA11/PIK3CB/IFNA7/COL6A1/TSC1/RELN/IKBKG/FASLG/VTN/STAT2/WNT2B/ATP6V0D1/LLGL2/PARD3/ATP6V1E1/ATP6V1E2/CTNNB1/HEY2/IFNAR1/LAMC1/AXIN1/APC/ATP6V1A/PRKCZ/ITGA2B/ATP6V1F/APC2/WNT9B/COL4A2/TCF7L1/CDC42/PARD6B/CCNA1/ATP6V1C1/ATP6AP1/BAX/PRKACA/ITGB6/TSC2/SLC9A3R1/CHAD/ISG15/BAD/GRB2/AKT3/TUBG1/FZD3/ATP6V1B1/EIF4EBP1/FZD7/PARD6A/ATM/CDK4/THBS4/WNT3/CREB1/RB1/RBPJL/IFNA1/THBS2/PARD6G/LAMB2/PIK3CD/TNR/FZD10/PPP2R5C/FZD6/PPP2R3A/TBPL1/MAP2K2/WNT5A/LAMB3/EP300/IKBKE/PIK3R3/TUBG2/PPP2R2C/CDK2/LAMA2/FZD4/IFNA5/PTEN/FZD8/NOTCH1/COL6A2/CSNK1A1/HES6/HES2/STAT1/PPP2R5D/IBSP/WNT11/HES5/PPP2R2A/SCRIB/TERT/HDAC2/TICAM1/TYK2/IFNA8/PPP2R3B/CRB3/WNT9A/IFNA6/TRAF3/PXN/NOTCH2/HES1/RBL2/UBR4/FOXO1/PTGS2/FN1/WNT7B/HES4/PRKACB/EIF2AK2/CREB3L1/IFNA21/NFX1/LAMA5/WNT8B/ITGA1/MAGI1/PIK3R2/COL9A2/HEY1/ATP6V0E2/IFNA2/NOTCH4/MAPK1/MFNG/PIK3CA/AKT1/IFNAR2/PRKCI/CDKN1A/AXIN2/MAPK3/ITGA2/WNT7A/HDAC1/THBS3/SPP1/MAP2K1/ATP6V0A1/HEYL/WNT5B/IRF9/THBS1/NOTCH3/BAK1/MAML2/LAMC2/ATP6V1G2/LAMC3/UBE3A/ATP6V1D/CCNE1/HES7/WNT4/ATP6V1G1/DVL1/FAS/SOS1/NFKB1/ITGA3/DLG3/ITGA8/ITGA6/PRKACG/TCIRG1/WNT10A/PPP2R5A	270
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	88/5985	100/8135	0.0003305	0.005809	0.003973	IL2RG/PF4V1/PF4/PPBP/CXCL5/CXCR2/IL10RB/CCL27/CXCR1/CCR3/CCL16/CX3CL1/CCL14/IL6R/CCR2/TNFSF10/CX3CR1/CCL24/TNFRSF10C/TNFSF14/ACKR4/IL6ST/TNFRSF10B/CCR1/TNFRSF1A/ACKR3/CCR5/CXCR4/IL22RA1/CXCL12/CCR7/CCL21/IL24/IL20RB/IL18RAP/CXCL10/IL19/CCL8/IL37/CCL5/TNFRSF1B/IL18/CCL17/IL20/CCL28/IL20RA/CCR9/CCL2/IL2/CXCL1/CCL25/IL10/CXCL2/CXCL9/CCR6/CCL20/CXCL3/CSF1/IL2RB/IL18R1/XCL1/CCL13/LTA/XCL2/CCR10/IL34/CCL1/CCL18/CXCL14/CCR4/IL10RA/CXCL8/TNFRSF14/CSF1R/CCL26/IL2RA/XCR1/CCL3/CCL3L1/CCL3L3/CCL22/CCR8/CXCL6/TNFRSF10A/CCL23/CXCR5/CCL4/IL6	88
KEGG	hsa05168	Herpes simplex virus 1 infection	396/5985	495/8135	0.0003659	0.006111	0.004179	TAPBP/TP53/ZNF785/ZNF528/SRSF3/ZNF490/PTPN11/ZNF460/ZNF791/CD74/ZNF816/ZNF566/IFNA10/ZNF3/ZNF484/IFNA16/ZNF7/NFKBIA/ZNF398/IFNA14/ZNF552/SRSF2/B2M/ZNF675/PPP1CC/ZNF549/RHEB/ZNF836/JAK1/TRADD/ZNF200/ZNF573/AKT2/RNASEL/ZNF425/ZNF846/ZNF74/IFNA17/ZNF248/HLA-C/HLA-G/ZNF563/ZNF763/TRAF6/FADD/ZNF189/ZNF8/ZNF107/PPP1CB/ZNF765/SOCS3/ZNF674/ZNF736/ZNF554/ZNF530/ZNF582/ZNF79/HCFC1/ZNF81/ZNF623/ZNF383/IRAK4/ZNF641/ZNF254/ZNF230/HLA-E/IFNA13/MTOR/EIF2B5/ZNF141/ZNF324B/RBAK/ZNF443/ZNF155/ZFP82/SRSF6/TNFSF14/ZNF671/ZNF891/CALR/ZNF2/SRSF4/ZNF419/IRF3/HLA-A/ITGB3/ZNF461/TLR2/MYD88/ZNF700/ZNF808/SRSF1/ZNF850/TAB1/ZNF331/IFNGR2/ZNF85/ITGA5/DAXX/HLA-B/MAP3K7/ZNF316/ZNF548/ZNF814/ZNF420/ZNF517/ZNF19/ZNF879/TNFRSF1A/IFNA4/SYK/PML/ZNF90/MAVS/TAP2/HLA-F/ZNF317/CHUK/ZNF689/ZNF136/ZNF180/IFIH1/ZNF627/ZNF749/PIK3CB/BID/ZNF557/HLA-DPA1/IFNA7/IRF7/TSC1/ZNF268/ZNF682/ZNF253/IKBKG/NXF1/IFNGR1/FASLG/STAT2/ZNF597/ZNF140/ZFP90/NXF2/NXF2B/ZNF195/CASP9/ZNF680/ZNF20/SRSF5/BST2/ZNF829/ZNF43/ZNF430/ZNF669/ZNF558/ZNF256/IFNAR1/ZNF480/ZNF543/ZNF596/PILRA/ZNF570/ZFP14/TAP1/ZNF302/ZNF212/ZNF436/ZNF658/ZNF34/HLA-DMB/ZNF562/SRC/ZNF561/ZNF426/ZNF282/BAX/ZNF607/ZNF285/APAF1/ZNF304/CFP/EIF2AK1/ZNF624/ZNF777/TSC2/ZNF780B/BAD/HLA-DRB1/ZNF555/OAS1/ZNF823/AKT3/ZNF688/ZNF569/HLA-DQA2/ZNF547/ZNF214/ZNF418/ZNF251/HLA-DRA/EIF4EBP1/ZNF354C/ZNF234/HLA-DMA/ZSCAN32/ZNF589/ZNF221/ZNF559/ZNF41/ZNF84/IFNA1/ZFP37/ZNF169/ZNF486/ZNF223/ZNF284/CCL5/ZNF768/PIK3CD/ZNF182/SRPK1/PILRB/ZNF709/SRSF9/ZFP92/ZNF564/BCL2/ZNF782/ZNF273/ZNF577/ZNF333/ZNF211/ZNF649/HLA-DQB1/CCL2/ZFP1/ZNF235/ZNF479/IKBKE/PIK3R3/ALYREF/ZNF630/ZNF99/ZNF764/ZNF184/ZNF616/ZNF611/ZNF233/IFNA5/ZNF619/ZNF780A/POU2F3/ZNF606/ZNF506/ZNF37A/STAT1/HLA-DOB/ZNF324/EIF2AK4/ZNF205/TRAF2/HLA-DRB4/ZNF14/ZNF718/ZFP69/IFNG/ZNF615/IL1B/EIF2B2/TICAM1/TLR9/ZNF124/ZNF439/ZFP28/ZNF778/ZNF441/PPP1CA/EIF2B4/HLA-DOA/TYK2/IFNA8/ZNF551/ZNF578/SRSF8/ZFP57/ZNF93/CARD9/ZNF135/ZNF227/ZNF404/ZNF257/ZNF600/IFNA6/ZNF583/TRAF3/ZNF610/ZNF514/ZNF175/ZNF100/ZNF91/EIF2B3/LTA/ZNF160/ZNF665/ZNF432/ZNF26/EIF2B1/ZNF717/ZNF442/ZNF707/ZNF226/EIF2S1/ZNF614/ZNF44/EIF2AK2/ZNF286A/HLA-DPB1/IFNA21/ZNF519/ZNF560/ZNF595/PIK3R2/ZNF154/ZNF133/ZNF224/ZNF677/ZNF766/TAB2/ZNF529/JAK2/ZNF544/ZNF556/ZNF527/IFNA2/ZNF550/ZNF621/DDX58/ZNF701/EIF2AK3/ZNF567/TNFRSF14/ZNF33A/PIK3CA/AKT1/IFNAR2/IRAK1/ZIM3/ZNF101/ZNF585B/C5/SP100/ZNF311/ZNF354A/ZNF132/OAS3/ZNF77/ZNF415/ZNF10/ZNF347/ZNF157/HCFC2/ZNF112/IRF9/ZNF587/ZNF546/HLA-DQA1/NXF3/ZNF473/ZNF599/ZNF334/POU2F1/ZNF468/ZNF17/ZNF746/BAK1/ZNF793/ZNF613/ZNF667/ZNF45/PDIA3/FAS/ZNF670/ZNF208/OAS2/ZNF662/NFKB1/IL6/ZNF33B/ZNF337/IL12A/ZNF571/ZNF382/ZNF320/ZNF510/BCL2L1/BIRC3	396
KEGG	hsa04722	Neurotrophin signaling pathway	103/5985	119/8135	0.0004448	0.007074	0.004838	ARHGDIB/YWHAE/TP53/ARHGDIA/NFKBIB/HRAS/SHC1/PTPN11/MAPKAPK2/KRAS/NFKBIA/PSEN1/JUN/BRAF/RPS6KA5/AKT2/TRAF6/GSK3B/NTF4/RAF1/SH2B2/NTRK3/NRAS/FRS2/SOS2/IRAK4/KIDINS220/MAP3K5/NTF3/MAP2K5/PDPK1/ZNF274/CALM2/CALM3/MAPK8/SH2B3/CALML5/CALML4/SH2B1/MAPK9/IRS1/CRK/PIK3CB/NTRK1/FASLG/CAMK2G/CALML3/RPS6KA1/CALML6/MAP3K3/RPS6KA3/RAC1/CALM1/CDC42/PRKCD/NGF/BAX/BAD/GRB2/AKT3/IRAK2/MAPK7/RAP1A/PIK3CD/PSEN2/MATK/BCL2/RHOA/MAP2K2/PIK3R3/RAPGEF1/SHC3/GAB1/RPS6KA6/ATF4/TP73/PLCG2/BDNF/NTRK2/IRAK3/RAP1B/RIPK2/SORT1/CAMK2D/PIK3R2/ARHGDIG/MAPK1/PIK3CA/AKT1/IRAK1/NGFR/MAPK3/ABL1/RPS6KA2/MAPK14/MAP2K1/MAP2K7/MAPK13/SHC2/FOXO3/SOS1/NFKB1/CAMK2B	103
KEGG	hsa05010	Alzheimer disease	310/5985	384/8135	0.0004986	0.007569	0.005177	PSMD7/PSMA3/HRAS/ARAF/SDHC/ATP2A3/ND3/SLC39A9/TUBB1/SNCA/DVL3/FZD2/COX7B/ND6/KRAS/AMBRA1/PSENEN/NDUFA10/PSEN1/COX6C/UQCRB/BRAF/COX7C/KLC3/PIK3R4/HSD17B10/SDHD/NDUFA1/AKT2/WNT2/ATG2B/ND2/ADAM10/NDUFB7/PSMB3/GSK3B/MME/FADD/NDUFB6/FRAT2/ITPR2/RAF1/PPP3CC/NCSTN/FRAT1/COX3/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NRAS/NDUFS5/NRBF2/ATP2A2/PLCB3/MAP3K5/CSNK2A1/PSMC2/KLC1/COX1/SLC39A8/APOE/MTOR/PSMB1/ATF6/CSNK2B/UQCR10/SLC39A6/WNT8A/BECN1/NDUFA4/NDUFS7/KIF5A/COX2/NDUFA3/CALM2/CALM3/PSMA5/NDUFA11/MAPK8/NDUFA6/DKK1/COX8A/SLC25A31/NOX1/TNFRSF1A/XBP1/NDUFV1/WNT1/APH1B/RTN4/TUBA1C/CALML5/CHUK/CALML4/MAPK9/SLC25A4/BACE2/IRS1/NDUFA8/PIK3CB/BID/NOS1/ATP6/NDUFA2/IKBKG/COX5B/WIPI2/IDE/WNT2B/COX6B2/GAPDH/CASP9/TUBA1A/PSMB5/PPP3CA/CTNNB1/RTN3/PPID/PSMB4/UQCRQ/COX6A1/NDUFA13/CALML3/CYC1/CALML6/NDUFB1/CAPN2/AXIN1/INS/GRIN2B/APC/NDUFA7/ATG14/APC2/WNT9B/CDK5/PIK3C3/AGER/COX7A1/PSMB2/PSMC6/PSMD11/CALM1/RYR3/TUBA1B/SLC39A2/PSMD1/ULK1/UQCRFS1/NDUFB2/APAF1/APBB1/NDUFB10/SDHB/BAD/NDUFS6/PSMD2/AKT3/NDUFS3/ND4/GRIN1/FZD3/SLC25A6/NDUFV3/CACNA1F/FZD7/CAPN1/ATG13/NOX4/PSMA1/WNT3/GRIN2A/PIK3CD/CHRM5/SLC39A13/FZD10/TUBA3C/TUBA3D/PSEN2/TUBB6/PLCB4/CHRM1/FZD6/NOS2/SLC11A2/SLC25A5/UQCRC1/PSMB6/VDAC1/MAP2K2/PSMD3/WNT5A/PIK3R3/APH1A/NDUFA9/TUBB2A/FZD4/SLC39A5/PSMA7/FZD8/NDUFS4/SLC39A10/CSNK1A1/DKK4/NDUFB5/LRP6/ATF4/UQCRC2/SLC39A14/TRAF2/GNAQ/RB1CC1/WNT11/ATP2A1/GRM5/PSMC5/CACNA1C/PSMA4/NDUFA4L2/ITPR3/IL1B/ERN1/TUBA4A/SLC39A1/CSF1/PPP3CB/ADRM1/PSMD9/CACNA1D/COX7A2L/UQCR11/CASP12/NDUFB9/WNT9A/PSMA8/SLC39A11/NDUFV2/NDUFB8/CHRM3/PTGS2/WNT7B/KIF5C/EIF2S1/ATG101/EIF2AK2/PLCB2/PSMC3/WNT8B/SLC39A7/NDUFS1/PIK3R2/GRIN2C/MAPT/TUBB4A/DDIT3/NDUFS2/PSMD12/NDUFB4/ITPR1/COX6B1/SLC39A4/TUBB3/EIF2AK3/MAPK1/PIK3CA/AKT1/IRS2/BACE1/PPIF/GRIN2D/AXIN2/MAPK3/TUBB4B/WNT7A/PSMA2/LRP1/PSMD4/VDAC2/NDUFB3/MAP2K1/DKK2/COX5A/CSNK2A2/TUBA8/WNT5B/IL1A/PSMB7/TUBB/KLC4/MAP2K7/APP/LRP5/ATG2A/SLC39A3/PSMD8/WNT4/DVL1/PPP3R1/FAS/TUBAL3/NFKB1/IL6/NDUFAB1/MCU/PLCB1/VDAC3/COX8C/WNT10A	310
KEGG	hsa04630	JAK-STAT signaling pathway	137/5985	162/8135	0.0005386	0.007822	0.005349	IL2RG/MCL1/JAK3/HRAS/PTPN11/CTF1/STAM2/IFNA10/EGFR/IFNA16/IFNA14/JAK1/AKT2/IL10RB/IFNA17/CISH/PTPN2/EGF/GH2/RAF1/SOCS4/SOCS3/IL6R/SOS2/CNTF/CSF2RB/IFNLR1/CSF2/IFNA13/MTOR/CSF2RA/IL12RB1/PRL/IL6ST/SOCS7/LIF/IL3/SOCS1/IFNGR2/CCND2/STAT5B/CREBBP/AOX1/IFNA4/CSF3R/PDGFA/STAM/IL13RA1/IL5/PIK3CB/IFNK/IFNA7/IL22RA1/IL27RA/IFNGR1/STAT2/GH1/IFNAR1/PIAS4/IL24/IL20RB/CSF3/CNTFR/IL11/IL4/GRB2/AKT3/IFNW1/IL21/EPO/CSH2/IL19/IL23R/OSM/STAT5A/IFNA1/PDGFRA/PIK3CD/IFNE/IL20/BCL2/PIAS2/IL20RA/LEPR/PIM1/IL2/IL13RA2/IL17D/EP300/PIK3R3/IL7R/EPOR/IL10/IL11RA/IFNA5/STAT1/IL23A/IFNG/IFNL2/IL2RB/TYK2/IFNA8/IFNL3/GFAP/IFNA6/IL21R/IL4R/TSLP/IL3RA/IFNL1/FHL1/IFNA21/SOCS5/PIK3R2/STAT3/JAK2/IFNA2/IL10RA/IL5RA/IL15/PIK3CA/AKT1/IFNAR2/CDKN1A/IL2RA/OSMR/IL15RA/STAT4/IRF9/IL12RB2/IL9/SOS1/PTPN6/IL9R/IL6/IL12A/BCL2L1	137
KEGG	hsa05164	Influenza A	144/5985	171/8135	0.0005828	0.008111	0.005547	NFKBIB/RAB11B/TMPRSS2/HNRNPUL1/PABPN1/IFNA10/IFNA16/NFKBIA/IFNA14/BCL2L2-PABPN1/CDK6/JAK1/TRADD/AKT2/RNASEL/IFNA17/ACTG1/FADD/RAF1/SOCS3/ACTB/IRAK4/RAE1/TNFSF10/IFNA13/PYCARD/IRF3/MX2/XPO1/MYD88/NLRX1/TNFRSF10B/IFNGR2/SLC25A31/CREBBP/TNFRSF1A/IFNA4/PML/MAVS/CALCOCO2/CHUK/MX1/IFIH1/SLC25A4/TRIM25/PIK3CB/BID/HLA-DPA1/IFNA7/IRF7/IKBKG/NXF1/IFNGR1/FASLG/STAT2/NXF2/NXF2B/CASP9/RSAD2/IFNAR1/TLR7/TLR4/PRKCA/ADAR/HLA-DMB/BAX/APAF1/DNAJB1/KPNA2/HLA-DRB1/OAS1/AKT3/HLA-DQA2/CXCL10/SLC25A6/HLA-DRA/TPSD1/CDK4/HLA-DMA/FDPS/IFNA1/CCL5/CIITA/IL18/PIK3CD/CASP1/SLC25A5/CPSF4/VDAC1/HLA-DQB1/MAP2K2/CCL2/EP300/IKBKE/NXT1/PIK3R3/IFNA5/TMPRSS11D/PLG/STAT1/HLA-DOB/HLA-DRB4/IFNG/IL1B/TICAM1/PRSS2/HLA-DOA/TYK2/IFNA8/IFNA6/TRAF3/EIF2S1/EIF2AK2/HLA-DPB1/IFNA21/TPSB2/PIK3R2/JAK2/IFNA2/DDX58/RAB11A/CXCL8/PRSS1/MAPK1/PIK3CA/AKT1/IFNAR2/MAPK3/TPSAB1/OAS3/MAP2K1/IRF9/HLA-DQA1/IL1A/NXF3/TNFRSF10A/BAK1/KPNA5/FAS/OAS2/NFKB1/IL6/IL12A/KPNA6	144
KEGG	hsa04010	MAPK signaling pathway	240/5985	294/8135	0.0006207	0.008293	0.005671	JUND/TP53/MAX/HRAS/ARAF/MAP3K12/DUSP1/ATF2/MAPKAPK2/EGFR/KRAS/NFKB2/ELK4/JUN/MKNK1/BRAF/CACNG6/RPS6KA5/RASGRP2/CACNG8/TRADD/AKT2/TAOK2/MAPK8IP3/TRAF6/EGF/CACNG5/FGF8/ANGPT2/NTF4/AREG/RAF1/PPP3CC/RASA1/CACNA1H/MKNK2/EFNA1/NRAS/FGFR4/SOS2/CACNA2D3/FGFR3/SRF/DUSP6/IRAK4/MAP3K5/FGF3/NTF3/MAP2K5/TEK/NF1/FLT4/HSPA1L/FGF4/CD14/HSPA1A/HSPA1B/MYD88/MAP4K2/MAPK8/TAB1/DAXX/HSPA6/MAP3K7/MAP2K3/TNFRSF1A/CACNG2/PDGFA/ANGPT1/MAP2K4/HSPB1/CHUK/MAPK9/CACNG1/FGF23/MAPKAPK5/CRK/IGF1R/CACNG4/PLA2G4F/IKBKG/NTRK1/FGF16/MAPK8IP1/FASLG/GADD45A/MEF2C/PTPN5/MAP3K4/CACNG7/MAP3K6/PPP3CA/PAK2/ERBB2/MAP3K2/PTPRR/RPS6KA1/MAP3K3/PLA2G4A/INS/RPS6KA3/RELB/DUSP2/RAC1/MAP3K11/FLT1/CACNB2/PAK1/PRKCA/CDC42/DUSP10/MET/FGF9/NGF/FGF18/RASGRP4/PDGFC/CACNB1/FGF19/FGF20/PRKACA/FGFR1/DUSP16/MAP4K1/TGFBR1/MAP3K13/GRB2/PTPN7/AKT3/KIT/CACNA1G/FLT3LG/TGFA/CACNA1F/GNA12/RASA2/PPM1B/CACNA1A/STK4/MAPK7/PDGFRA/FGF1/RAP1A/RAPGEF2/HGF/TAOK3/FGF2/RASGRP3/RAC3/FGF22/ANGPT4/IL1RAP/JMJD7-PLA2G4B/MAP2K2/TGFBR2/MAP4K3/TGFB1/DUSP4/PRKCG/PPP5C/FLNB/IL1R1/GADD45B/RPS6KA6/EFNA3/ATF4/TRAF2/KITLG/EPHA2/BDNF/NTRK2/CACNA1C/IL1B/FGF21/RAC2/CSF1/CACNA2D1/PPP3CB/FOS/RAP1B/CACNA1D/PGF/PDGFD/RASGRF1/MECOM/NLK/FLNC/PRKACB/LAMTOR3/ECSIT/EREG/MAPT/STMN1/FGF17/ARRB2/TAB2/VEGFC/CACNG3/CACNB3/DDIT3/ERBB4/MAPK1/AKT1/ERBB3/CSF1R/GNG12/IRAK1/MAPKAPK3/MAP4K4/NGFR/CACNB4/MAPK3/STK3/TAOK1/DUSP9/FGF5/RPS6KA2/MAPK14/CACNA1I/PPM1A/MAP2K1/CACNA1E/RASGRF2/HSPA8/IL1A/ELK1/MAP2K7/NR4A1/TGFB3/MAPK13/PPP3R1/FAS/HSPA2/SOS1/NFKB1/ARRB1/FLT3/PRKACG/EFNA4/VEGFB	240
KEGG	hsa00562	Inositol phosphate metabolism	65/5985	73/8135	0.0009752	0.01253	0.008568	ISYNA1/PIP5K1A/PIKFYVE/MTMR7/MTMR1/INPP5K/CDIPT/MTMR14/SYNJ1/ITPK1/INPPL1/PLCB3/MIOX/PI4KB/IMPA2/FIG4/PIP4K2B/PLCH2/TPI1/PIK3C2B/MINPP1/PIK3CB/PIP5K1C/PIK3C3/ITPKA/MTM1/MTMR2/INPP1/INPP4A/PI4K2B/PLCD4/ALDH6A1/PIK3C2A/PLCE1/MTMR3/SACM1L/PIK3CD/IPMK/PIP5K1B/PIK3C2G/PLCB4/PLCD3/MTMR4/INPP5J/IPPK/INPP5B/INPP5E/PTEN/OCRL/PLCG2/IMPA1/PLCH1/INPP5F/PLCB2/PIP4K2A/PI4K2A/PIK3CG/ITPKB/PIK3CA/INPP5D/MTMR8/INPP4B/PLCB1/MTMR6/PLCD1	65
KEGG	hsa04720	Long-term potentiation	60/5985	67/8135	0.001084	0.01294	0.008851	HRAS/ARAF/KRAS/BRAF/PPP1CC/ITPR2/PPP1CB/RAF1/PPP3CC/NRAS/PLCB3/GRM1/CALM2/CALM3/CREBBP/CALML5/CALML4/CAMK2G/PPP3CA/CALML3/RPS6KA1/CALML6/GRIN2B/RPS6KA3/ADCY8/PRKCA/CALM1/PRKACA/PPP1R1A/GRIN1/GRIN2A/RAP1A/PLCB4/MAP2K2/EP300/PRKCG/RPS6KA6/ATF4/GNAQ/GRM5/CACNA1C/ITPR3/PPP3CB/PPP1CA/RAP1B/CAMK2D/PRKACB/PLCB2/GRIN2C/GRIA2/ITPR1/MAPK1/GRIN2D/MAPK3/RPS6KA2/MAP2K1/PPP3R1/PLCB1/CAMK2B/PRKACG	60
KEGG	hsa05132	Salmonella infection	204/5985	249/8135	0.001085	0.01294	0.008851	PFN1/DCTN1/PKN1/RAB7A/BRK1/CYTH1/HRAS/DYNLL2/DCTN2/MYL12A/TUBB1/ARPC1B/RAB5C/NFKBIA/DYNC1H1/ARPC4/RAB5A/JUN/RAB9B/KLC3/DCTN6/RILP/TRADD/AKT2/ACTG1/AHNAK/TRAF6/VPS18/FADD/GCC2/RAF1/TLR6/ACTR3/ACTB/CYTH4/TXN/IRAK4/TNFSF10/KLC1/DNM2/PODXL/ARPC1A/ARF6/PYCARD/CYTH3/STX10/ACTR10/ACTR2/HSP90AB1/CD14/DYNLL1/EXOC7/KIF5A/TLR2/MYD88/CYFIP1/MAPK8/TAB1/MLKL/WASF3/TNFRSF10B/MAP3K7/MAP2K3/PLEKHM1/TNFRSF1A/VPS16/ARPC5L/TUBA1C/MAP2K4/CHUK/TXN2/DYNLT1/MAPK9/PIK3C2B/ROCK2/PIK3CB/IKBKG/PLEKHM2/TAB3/GAPDH/TUBA1A/SNX33/ACBD3/RHOB/CTNNB1/EXOC4/NCKAP1L/CASP4/DCTN3/TLR4/RAC1/RAB9A/PIK3C3/PAK1/TCF7L1/CDC42/TUBA1B/TLR5/HSP90B1/AHNAK2/VPS33A/FBXO22/BAX/ABI1/PFN2/CASP5/RIPK3/RHOG/NAIP/EXOC5/AKT3/PIK3C2A/ARPC2/RHOJ/ANXA2/WASL/IL18/PIK3CD/TUBA3C/TUBA3D/PIK3C2G/TUBB6/BCL2/CASP1/RHOA/ELMO2/PAK3/MAP2K2/MYL7/FLNB/S100A10/TIRAP/TUBB2A/MYL9/DYNC1I2/ARHGEF26/RAB7B/TRAF2/IL1B/CYTH2/TUBA4A/HSP90AA1/TLR9/EXOC2/DYNC1I1/FOS/RHOH/RIPK2/LY96/NOD1/ARF1/VPS11/MYLPF/RPS3/DYNLRB2/KIF5C/FLNC/DYNC1LI1/PTPRC/GSDMD/MYL5/TUBB4A/TAB2/MYL12B/KPNA3/ACTR1A/PIK3CG/CXCL8/TUBB3/MAPK1/CYFIP2/PIK3CA/AKT1/MYO6/IRAK1/KPNA4/DCTN5/SNX18/MAPK3/TUBB4B/MAPK14/M6PR/ACTR1B/MAP2K1/TUBA8/VPS41/NCKAP1/ARPC3/TNFRSF10A/BAK1/TUBB/NLRC4/KLC4/MAP2K7/DCTN4/MAPK13/DYNLRB1/DYNC2LI1/TUBAL3/NFKB1/RALA/DYNLT3/IL6/BIRC3	204
KEGG	hsa04146	Peroxisome	72/5985	82/8135	0.001343	0.01547	0.01058	MPV17L/PEX10/NUDT7/BAAT/HMGCL/PEX12/IDH1/PECR/XDH/ACSL1/CRAT/DAO/ECH1/GNPAT/FAR1/PEX13/ABCD3/ECI2/DHRS4/PXMP4/CAT/ACOT8/SCP2/ACOX1/HAO1/PEX26/EPHX2/PRDX1/ACSL6/ACSL4/FAR2/DECR2/NOS2/PEX1/AGPS/PEX11A/PEX11G/PEX6/IDH2/ACSL3/PEX3/MLYCD/PEX14/MVK/ABCD2/PAOX/NUDT19/AGXT/PEX5L/SLC25A17/ABCD1/HMGCLL1/PXMP2/PHYH/PEX5/ABCD4/PEX7/SOD2/MPV17/EHHADH/PEX16/GSTK1/PRDX5/SLC27A2/HACL1/MPV17L2/NUDT12/AMACR/PMVK/DDO/HSD17B4/PEX19	72
KEGG	hsa04144	Endocytosis	205/5985	251/8135	0.001447	0.01611	0.01102	IL2RG/RAB7A/RAB11B/CYTH1/HRAS/RABEP1/PSD4/SMURF1/RUFY2/STAM2/MDM2/AGAP6/ACAP2/SH3KBP1/ARPC1B/PIP5K1A/SPG21/EGFR/RAB5C/ARPC4/RAB5A/CXCR2/GBF1/SMAD3/CLTC/HLA-C/HLA-G/VPS28/DAB2/TRAF6/ARF5/CXCR1/GIT1/EHD3/IQSEC3/ASAP2/CLTA/GRK7/ARFGEF2/SNX3/SNX32/ACTR3/CYTH4/VPS37B/FGFR4/CHMP2A/FGFR3/CHMP4C/EHD2/CAV3/WIPF2/MVB12A/IGF2R/HLA-E/DNM2/VPS25/CAPZA1/CHMP3/RNF103-CHMP3/ARPC1A/HSPA1L/ARF6/TSG101/EPN3/ARAP1/PSD2/FOLR3/CYTH3/AGAP3/ACTR2/PSD/HSPA1A/HSPA1B/HLA-A/RAB11FIP3/SNX6/KIF5A/ITCH/ARFGEF1/SNX12/NEDD4L/TFRC/AP2A2/PDCD6IP/EHD4/VPS37C/VPS26A/RAB11FIP1/HLA-B/HSPA6/ARAP2/CAV1/RAB31/RAB8A/CBLC/PML/ARPC5L/RAB10/HLA-F/CCR5/CXCR4/SNX1/STAM/RAB11FIP4/CAV2/IGF1R/EEA1/AP2B1/SNX5/GRK6/ASAP3/PARD3/VPS4B/ARF4/AGAP2/PIP5K1C/PRKCZ/ARAP3/GRK1/AP2S1/VPS35/SNX4/CDC42/PARD6B/MVB12B/SRC/SMAP1/ZFYVE9/AP2A1/LDLR/IST1/EPN2/TGFBR1/LDLRAP1/SH3GLB1/EPN1/FOLR1/ARPC2/PARD6A/SMAD2/AMPH/PDGFRA/WASL/PARD6G/PIP5K1B/CAPZA2/RHOA/ARFGAP3/USP8/TGFBR2/ARF3/CHMP6/PLD1/SH3GLB2/VPS36/AGAP9/DNAJC6/GIT2/RAB4A/PSD3/WWP1/CYTH2/IQSEC2/RAB11FIP5/BIN1/EPS15L1/IL2RB/GRK5/AGAP4/ARF1/RAB35/SH3GL3/DNM3/IQSEC1/CHMP7/KIF5C/VTA1/SH3GL1/EHD1/RAB22A/SH3GL2/RNF41/ARRB2/ASAP1/VPS45/RAB11A/CHMP1A/AGAP5/ARFGAP2/PRKCI/IL2RA/FOLR2/ZFYVE16/HSPA8/ARPC3/VPS29/CBLB/CHMP4A/CLTCL1/HSPA2/EPS15/ARRB1/WIPF3/WIPF1/RAB11FIP2	205
KEGG	hsa04020	Calcium signaling pathway	196/5985	240/8135	0.001841	0.01983	0.01356	ATP2A3/EGFR/PLN/PTK2B/CHRM2/MYLK4/AVPR1B/CASQ2/MYLK3/SLC8A3/EGF/TNNC1/ADRA1B/ITPR2/ORAI2/FGF8/PPP3CC/PTAFR/NTRK3/CACNA1H/NOS3/FGFR4/ATP2A2/FGFR3/PLCB3/ADCY7/P2RX5/FGF3/HTR2B/PHKG1/GRPR/GRM1/FLT4/ORAI3/SPHK1/FGF4/SPHK2/CALM2/CALM3/P2RX6/SLC25A31/MYLK/OXTR/PDGFA/CXCR4/CALML5/AVPR1A/PHKB/CALML4/FGF23/SLC25A4/NOS1/GNA15/HRH1/NTRK1/FGF16/LTB4R2/CAMK2G/CAMK1D/PPP3CA/MCOLN1/ERBB2/CALML3/CALML6/ADCY9/ORAI1/CAMK1G/ADCY8/FLT1/P2RX3/ITPKA/GNA11/PRKCA/CALM1/ADRA1D/RYR3/GNAL/MET/FGF9/NGF/STIM2/CASQ1/FGF18/PTGER1/PDGFC/FGF19/FGF20/PRKACA/FGFR1/ADORA2B/SLC8A2/CYSLTR1/PLCD4/GDNF/DRD5/GRIN1/SLC25A6/CACNA1G/HTR7/CACNA1F/EDNRB/PLCE1/CACNA1A/GRIN2A/HRH2/PDGFRA/F2R/FGF1/CHRM5/HGF/PLCB4/CHRM1/PLCD3/FGF2/P2RX7/NOS2/FGF22/SLC25A5/CD38/ADORA2A/VDAC1/P2RX4/GNA14/ATP2B3/PRKCG/HTR4/TPCN1/ASPH/GNAQ/PLCG2/ATP2A1/GRM5/NTRK2/ATP2B4/CACNA1C/ATP2B2/ITPR3/FGF21/EDNRA/NTSR1/PPP3CB/CACNA1D/PDGFD/AGTR1/PHKA1/CCKAR/PDE1C/ATP2B1/MYLK2/CHRM3/PTGFR/P2RX1/CAMK2D/ADRB2/PRKACB/PLCB2/RYR2/GRIN2C/PHKG2/FGF17/CYSLTR2/VEGFC/HTR2A/ITPR1/ERBB4/TACR1/ITPKB/ERBB3/PPIF/GRIN2D/ADRB1/FGF5/VDAC2/HTR2C/CACNA1I/PDE1B/CACNA1E/TRDN/PHKA2/DRD1/TACR3/MST1R/LOC102723407/ADCY3/PPP3R1/HRC/TBXA2R/MCU/PLCB1/CAMK2B/BDKRB1/VDAC3/PRKACG/TRHR/VEGFB/PLCD1	196
KEGG	hsa04216	Ferroptosis	38/5985	41/8135	0.00207	0.0216	0.01478	TP53/SLC40A1/LPCAT3/GPX4/NCOA4/ATG5/ACSL1/GCLM/SLC39A8/PCBP1/MAP1LC3B/FTL/TFRC/CP/MAP1LC3A/ATG7/SLC7A11/SLC3A2/ACSL6/MAP1LC3C/GCLC/SAT2/ACSL4/SLC11A2/ACSL3/SLC39A14/MAP1LC3B2/ALOX15/GSS/TF/HMOX1/PCBP2/STEAP3/FTH1/SAT1/VDAC2/PRNP/VDAC3	38
KEGG	hsa05160	Hepatitis C	131/5985	157/8135	0.002163	0.02189	0.01497	YWHAE/TP53/PPP2R1A/HRAS/ARAF/PSME3/IFNA10/EGFR/KRAS/IFNA16/NFKBIA/IFNA14/BRAF/CLDN7/CDK6/JAK1/PPP2R2D/TRADD/CLDN17/AKT2/RNASEL/IFNA17/YWHAB/TRAF6/CLDN15/GSK3B/FADD/EGF/YWHAG/RAF1/SOCS3/CLDN3/NRAS/CLDN20/CLDN19/SOS2/IFNA13/CFLAR/IRF3/MX2/CLDN8/PPP2R1B/PPP2CA/RXRA/TNFRSF1A/IFNA4/MAVS/CHUK/MX1/PIK3CB/BID/IFNA7/IRF7/IKBKG/CLDN5/IFIT1/FASLG/STAT2/SCARB1/CASP9/RSAD2/CTNNB1/CLDN1/IFNAR1/CLDN4/BAX/APAF1/LDLR/EIF2AK1/BAD/OAS1/GRB2/AKT3/CXCL10/CDK4/E2F3/RB1/CLDN14/IFNA1/PIK3CD/CLDN16/MAP2K2/IKBKE/PIK3R3/PPP2R2C/CDK2/IFNA5/CLDN11/CLDN10/YWHAQ/STAT1/EIF2AK4/TRAF2/CD81/IFNG/PPP2R2A/TICAM1/TYK2/IFNA8/OCLN/IFNA6/TRAF3/CLDN18/YWHAH/EIF3E/EIF2S1/EIF2AK2/IFNA21/PIK3R2/STAT3/IFNA2/DDX58/EIF2AK3/MAPK1/PIK3CA/AKT1/IFNAR2/CDKN1A/MAPK3/OAS3/MAP2K1/CLDN23/NR1H3/IRF9/BAK1/FAS/SOS1/OAS2/NFKB1/CLDN9/YWHAZ	131
KEGG	hsa05169	Epstein-Barr virus infection	166/5985	202/8135	0.002376	0.02237	0.0153	TAPBP/TP53/NFKBIB/JAK3/PSMD7/SAP30/MDM2/IFNA10/SIN3A/IFNA16/NFKB2/NFKBIA/IFNA14/JUN/B2M/CDK6/SKP2/JAK1/TRADD/AKT2/IFNA17/HLA-C/HLA-G/NCOR2/TRAF6/FADD/CDKN1B/CD19/PSMD6/PSMC4/IRAK4/PSMC2/HLA-E/BLNK/IFNA13/CCNA2/RBPJ/BCL2L11/CALR/IRF3/HLA-A/TLR2/MYD88/TNFAIP3/MAPK8/CD44/TAB1/CR2/CCND2/HLA-B/MAP3K7/USP7/MAP2K3/CCNE2/IFNA4/SYK/MAVS/TAP2/HLA-F/MAP2K4/CHUK/MAPK9/PIK3CB/BID/HLA-DPA1/IFNA7/IRF7/IKBKG/STAT2/GADD45A/CASP9/LYN/IFNAR1/RELB/RAC1/CD247/TAP1/PSMC6/PSMD11/CCNA1/PSMD1/HLA-DMB/BAX/APAF1/ISG15/HLA-DRB1/CD40/OAS1/PSMD2/BTK/AKT3/HLA-DQA2/CXCL10/HLA-DRA/CDK4/HLA-DMA/E2F3/RB1/RBPJL/IFNA1/PIK3CD/BCL2/ITGAL/CIR1/ENTPD1/HLA-DQB1/PSMD3/IKBKE/PIK3R3/POLK/CDK2/IFNA5/GADD45B/STAT1/HLA-DOB/ENTPD3/TRAF2/PLCG2/HLA-DRB4/DDB2/PSMC5/SNW1/HDAC2/HLA-DOA/TYK2/ADRM1/IFNA8/IFNA6/TRAF3/HES1/SAP30L/RUNX3/EIF2AK2/HLA-DPB1/IFNA21/PSMC3/PIK3R2/STAT3/TAB2/IFNA2/PSMD12/DDX58/PIK3CA/AKT1/IFNAR2/IRAK1/VIM/CDKN1A/HDAC1/OAS3/PSMD4/MAPK14/IRF9/HLA-DQA1/BAK1/MAP2K7/LOC102723407/CCNE1/MAPK13/PSMD8/PDIA3/FAS/OAS2/NFKB1/CD3G/IL6	166
KEGG	hsa04640	Hematopoietic cell lineage	85/5985	99/8135	0.002401	0.02237	0.0153	GYPA/MME/ITGA4/CD19/IL6R/CD1A/MS4A1/CSF2/IL1R2/CD1B/CSF2RA/CD36/CD14/ITGB3/TFRC/CD44/GP1BB/CR1L/CR2/IL3/ITGA5/CSF3R/GP9/CD34/IL5/CD1D/CD33/HLA-DPA1/CD37/CD24/CD1C/ITGA2B/CSF3/GP5/HLA-DMB/IL11/IL4/HLA-DRB1/KIT/HLA-DQA2/CR1/HLA-DRA/FLT3LG/EPO/HLA-DMA/CD2/CD59/CD38/HLA-DQB1/CD8A/IL7R/EPOR/IL11RA/IL1R1/GP1BA/ITGAM/HLA-DOB/KITLG/DNTT/HLA-DRB4/IL1B/CD7/CSF1/HLA-DOA/CD55/FCGR1A/IL4R/IL3RA/HLA-DPB1/ITGA1/IL5RA/CSF1R/IL2RA/ITGA2/CD22/HLA-DQA1/IL1A/CD5/LOC102723407/ITGA3/CD3G/IL9R/ITGA6/IL6/FLT3	85
KEGG	hsa04380	Osteoclast differentiation	108/5985	128/8135	0.002424	0.02237	0.0153	JUND/JUNB/FOSB/NFKB2/NFKBIA/JUN/JAK1/AKT2/TRAF6/CYBA/TNFRSF11B/PPP3CC/SOCS3/TREM2/FHL2/BLNK/NCF1/ITGB3/FCGR3B/MAPK8/TAB1/SOCS1/IFNGR2/MAP3K7/NOX1/NCF4/TNFRSF1A/SYK/CHUK/NCF2/FCGR2B/MAPK9/PIK3CB/IKBKG/LILRA2/IFNGR1/STAT2/PPP3CA/LILRA5/IFNAR1/TYROBP/MITF/RELB/RAC1/LILRA6/LCK/LILRB3/FCGR3A/TGFBR1/GRB2/GAB2/BTK/AKT3/LILRB5/FOSL2/OSCAR/CREB1/NFATC2/PIK3CD/LILRB2/CTSK/LILRB1/TGFBR2/TGFB1/PIK3R3/CALCR/IL1R1/SIRPA/STAT1/TRAF2/PLCG2/PPARG/CYLD/IFNG/IL1B/FOSL1/CSF1/PPP3CB/FYN/TYK2/FOS/SQSTM1/LILRA4/FCGR1A/TNFRSF11A/ACP5/PIK3R2/LILRB4/TAB2/MAPK1/PIK3CA/AKT1/FCGR2A/IFNAR2/CSF1R/SIRPB1/LILRA1/MAPK3/MAPK14/TNFSF11/MAP2K1/LCP2/IRF9/IL1A/MAP2K7/MAPK13/PPP3R1/NFKB1	108
KEGG	hsa04218	Cellular senescence	130/5985	156/8135	0.002479	0.02237	0.0153	HIPK1/TP53/HIPK3/HRAS/MDM2/MAPKAPK2/KRAS/CDK6/SMAD3/PPP1CC/RHEB/ZFP36L1/CCNB3/ZFP36L2/AKT2/FBXW11/HLA-C/HLA-G/HUS1/ITPR2/PPP1CB/RAF1/PPP3CC/NFATC4/NRAS/HLA-E/CCNA2/MTOR/HLA-A/CALM2/CALM3/FOXM1/LIN52/CCND2/HLA-B/SLC25A31/MAP2K3/CCNE2/RBL1/HLA-F/CALML5/CALML4/SLC25A4/PIK3CB/TSC1/GADD45A/RAD9A/PPP3CA/PPID/RASSF5/CALML3/CALML6/CAPN2/CALM1/RAD9B/CCNA1/TSC2/RAD1/TGFBR1/TRPV4/AKT3/TRPM7/LIN9/SLC25A6/EIF4EBP1/CAPN1/ATM/CDK4/SMAD2/SIRT1/E2F3/RB1/NFATC2/PIK3CD/CCNB1/CHEK1/SLC25A5/VDAC1/MAP2K2/TGFBR2/BTRC/TGFB1/PIK3R3/CCNB2/CDK2/PTEN/GADD45B/ETS1/HIPK2/ITPR3/PPP3CB/PPP1CA/CACNA1D/IGFBP3/MYBL2/SQSTM1/CDKN2B/RBL2/FOXO1/E2F4/E2F5/RBBP4/PIK3R2/ITPR1/CXCL8/MAPK1/PIK3CA/AKT1/SERPINE1/CDKN1A/MAPK3/CDC25A/MAPK14/VDAC2/MAP2K1/IL1A/TGFB3/CCNE1/MAPK13/PPP3R1/NBN/FOXO3/CDKN2A/LIN54/NFKB1/HIPK4/IL6/MCU/CDK1/VDAC3	130
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	125/5985	150/8135	0.002983	0.02622	0.01793	PPP2R1A/ATF6B/PIK3R5/ATP2A3/PPP2R3C/ATF2/MYL4/PLN/TPM4/ATP1B3/CACNG6/RPS6KA5/MYH6/PPP1CC/CACNG8/MYH7/PPP2R2D/AKT2/TPM2/SLC8A3/TPM1/CACNG5/TNNC1/ADRA1B/ADCY6/PPP1CB/CREB5/ATP2A2/CACNA2D3/SCN1B/PPP2R5B/PLCB3/ADCY7/CREB3L3/CALM2/CALM3/PPP2R1B/CREB3/PPP2CA/TNNI3/CREB3L4/CACNG2/CALML5/CALML4/CACNG1/CACNG4/CACNG7/CAMK2G/ATP1B2/CALML3/CALML6/ADCY9/ATP1A3/ADCY8/CACNB2/TPM3/PRKCA/CALM1/ADRA1D/CACNB1/PRKACA/ACTC1/SLC8A2/PPP1R1A/ATP1A1/AKT3/CACNA1F/CREB1/CREM/PPP2R5C/PLCB4/BCL2/PPP2R3A/ATP2B3/PPP2R2C/KCNE1/PPP2R5D/ATF4/GNAQ/ATP2A1/AGT/ATP2B4/PPP2R2A/CACNA1C/ATP2B2/CACNA2D1/PPP1CA/PPP2R3B/AGTR2/CACNA1D/MYL3/AGTR1/ADCY5/ATP2B1/GNAI2/KCNQ1/CAMK2D/ADRB2/ATP1A2/PRKACB/CREB3L1/PLCB2/RYR2/SLC9A1/TNNT2/GNAI3/CACNG3/CACNB3/PIK3CG/PIK3R6/MAPK1/AKT1/SCN5A/CACNB4/ADRB1/MAPK3/MAPK14/SCN7A/RAPGEF4/MAPK13/ADCY3/PLCB1/CAMK2B/PRKACG/PPP2R5A	125
KEGG	hsa04068	FoxO signaling pathway	110/5985	131/8135	0.00312	0.02672	0.01827	HRAS/ARAF/MDM2/EGFR/KRAS/BRAF/SMAD3/SKP2/CCNB3/AKT2/S1PR4/EGF/GABARAPL2/PLK4/RAF1/CDKN1B/NRAS/SOS2/SMAD4/C8orf44-SGK3/SGK3/PLK1/FOXO6/TNFSF10/PDPK1/GRM1/BCL2L11/PRKAG3/MAPK8/CCND2/USP7/CAT/CREBBP/GABARAPL1/BCL6/CHUK/GABARAP/MAPK9/IRS1/IGF1R/PIK3CB/FASLG/GADD45A/PLK2/FOXG1/KLF2/AGAP2/ATG12/INS/STK11/SGK2/TGFBR1/GRB2/AKT3/PLK3/ATM/SIRT1/STK4/RAG1/CCNG2/PIK3CD/G6PC2/CCNB1/HOMER2/MAP2K2/TGFBR2/G6PC3/TGFB1/EP300/PIK3R3/IL7R/CCNB2/IL10/CDK2/PTEN/GADD45B/HOMER3/PRKAG1/BNIP3/FBXO25/PRMT1/PRKAB1/PCK2/CDKN2B/RBL2/FOXO1/NLK/RAG2/FOXO4/PIK3R2/STAT3/SOD2/MAPK1/PIK3CA/AKT1/IRS2/CDKN1A/HOMER1/MAPK3/SGK1/MAPK14/PRKAA1/MAP2K1/SETD7/TGFB3/MAPK13/FOXO3/SOS1/IL6/G6PC	110
KEGG	hsa04070	Phosphatidylinositol signaling system	83/5985	97/8135	0.003331	0.02761	0.01888	PIP5K1A/PIKFYVE/MTMR7/DGKE/MTMR1/IMPAD1/CDIPT/MTMR14/SYNJ1/ITPR2/ITPK1/INPPL1/PLCB3/PI4KB/PPIP5K2/IP6K1/IMPA2/CALM2/CALM3/DGKA/DGKK/PIP4K2B/CALML5/CALML4/PIK3C2B/PIK3CB/CALML3/CALML6/PIP5K1C/PIK3C3/ITPKA/PRKCA/CALM1/MTM1/MTMR2/INPP1/INPP4A/PI4K2B/PLCD4/CDS1/PIK3C2A/PLCE1/MTMR3/SACM1L/DGKG/PIK3CD/IPMK/PIP5K1B/PIK3C2G/PLCB4/PLCD3/MTMR4/IPPK/INPP5B/PIK3R3/DGKZ/PRKCG/INPP5E/PTEN/CDS2/OCRL/PLCG2/IP6K2/IMPA1/ITPR3/INPP5F/DGKQ/PLCB2/PIK3R2/PIP4K2A/PI4K2A/ITPR1/ITPKB/PIK3CA/DGKH/DGKB/INPP5D/MTMR8/INPP4B/PPIP5K1/PLCB1/MTMR6/PLCD1	83
KEGG	hsa04662	B cell receptor signaling pathway	71/5985	82/8135	0.00339	0.02761	0.01888	NFKBIB/HRAS/KRAS/NFKBIA/JUN/AKT2/DAPP1/GSK3B/RAF1/PPP3CC/INPPL1/CD19/NRAS/SOS2/BLNK/CR2/SYK/CHUK/FCGR2B/IFITM1/PIK3CB/IKBKG/LILRA2/PPP3CA/LYN/LILRA5/RAC1/CD72/VAV1/LILRA6/LILRB3/GRB2/BTK/AKT3/LILRB5/NFATC2/PIK3CD/LILRB2/RASGRP3/RAC3/LILRB1/MAP2K2/CD79A/PIK3R3/MALT1/PLCG2/CD81/RAC2/PPP3CB/FOS/CARD11/LILRA4/VAV2/CD79B/PIK3R2/LILRB4/VAV3/MAPK1/PIK3CA/AKT1/PIK3AP1/LILRA1/MAPK3/CD22/MAP2K1/INPP5D/LOC102723407/PPP3R1/SOS1/NFKB1/PTPN6	71
KEGG	hsa05163	Human cytomegalovirus infection	183/5985	225/8135	0.003686	0.02895	0.0198	TAPBP/TP53/ATF6B/GNG2/HRAS/MDM2/IFNA10/ATF2/EGFR/KRAS/IFNA16/NFKBIA/PTK2B/IFNA14/GNG11/GNG4/B2M/CXCR2/CDK6/RHEB/JAK1/TRADD/AKT2/IL10RB/IFNA17/HLA-C/HLA-G/SP1/GSK3B/FADD/CCR3/ITPR2/ADCY6/RAF1/PPP3CC/CX3CL1/PTGER4/CREB5/NFATC4/NRAS/RPS6KB2/IL6R/SOS2/PLCB3/ADCY7/HLA-E/IFNA13/MTOR/GNB2/CREB3L3/CALR/IRF3/HLA-A/ITGB3/CALM2/CALM3/ROCK1/RPS6KB1/GNG5/CREB3/HLA-B/ARHGEF12/CCR1/TNFRSF1A/IFNA4/CREB3L4/GNA13/GNG10/TAP2/HLA-F/CCR5/CXCR4/CALML5/CHUK/PTK2/CALML4/ROCK2/CRK/PIK3CB/BID/IFNA7/GNGT1/TSC1/IKBKG/FASLG/CASP9/ARHGEF1/PPP3CA/CXCL12/CTNNB1/PTGER2/CALML3/CALML6/GNG7/ADCY9/RAC1/TAP1/ADCY8/GNA11/PRKCA/CALM1/SRC/GNG8/PTGER1/BAX/PRKACA/TSC2/GRB2/AKT3/EIF4EBP1/CDK4/GNA12/E2F3/CREB1/RB1/NFATC2/IFNA1/PDGFRA/CCL5/PIK3CD/GNG13/PLCB4/RHOA/RAC3/MAP2K2/CCL2/PIK3R3/PRKCG/IFNA5/IL1R1/ATF4/TRAF2/GNAQ/GNG3/ITPR3/IL1B/RAC2/PPP3CB/IFNA8/IFNA6/PXN/ADCY5/PTGS2/GNAI2/PRKACB/CREB3L1/IFNA21/PLCB2/GNAI3/PIK3R2/STAT3/IFNA2/IL10RA/ITPR1/CXCL8/MAPK1/PIK3CA/AKT1/GNG12/CDKN1A/MAPK3/CCL3/CCL3L1/CCL3L3/MAPK14/BCAR1/GNAO1/MAP2K1/BAK1/ELK1/MAPK13/ADCY3/PDIA3/PPP3R1/FAS/CDKN2A/SOS1/NFKB1/GNB4/CCL4/IL6/PLCB1/PRKACG	183
KEGG	hsa05144	Malaria	45/5985	50/8135	0.003727	0.02895	0.0198	HBB/GYPA/GYPC/HBA1/HBA2/GYPB/SELP/ACKR1/COMP/CD36/TLR2/MYD88/CR1L/TLR4/CSF3/MET/SELE/CD40/CR1/THBS4/CD40LG/THBS2/IL18/HGF/ITGAL/CCL2/TGFB1/IL10/ITGB2/CD81/IFNG/IL1B/TLR9/SDC2/PECAM1/KLRB1/CXCL8/THBS3/LRP1/KLRC4-KLRK1/KLRK1/THBS1/TGFB3/IL6/IL12A	45
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	375/5985	476/8135	0.004005	0.0304	0.02079	DCTN1/FUS/PSMD7/PSMA3/HRAS/ARAF/SPG11/SDHC/UBA1/ATP2A3/ND3/DCTN2/TUBB1/UBB/SNCA/DVL3/FZD2/COX7B/ND6/KRAS/AMBRA1/NDUFA10/ATXN2L/PSEN1/COX6C/RAB5A/UQCRB/BRAF/COX7C/KLC3/SIGMAR1/PIK3R4/DNAH1/DCTN6/HSD17B10/SDHD/GPX1/NDUFA1/UBA52/WNT2/ATG2B/ND2/DNAH17/NDUFB7/UBA7/PSMB3/GSK3B/FADD/NDUFB6/FRAT2/ITPR2/RAF1/PPP3CC/HAP1/PINK1/FRAT1/COX3/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NRAS/NDUFS5/SMCR8/NRBF2/ATP2A2/GPX2/VCP/PLCB3/MAP3K5/CSNK2A1/PSMC2/KLC1/GPX3/COX1/MTOR/GRM1/PRPH/CCS/PSMB1/ATF6/TOMM40/CSNK2B/SLC6A3/UQCR10/ACTR10/DNAL4/MAP1LC3B/WNT8A/IFT57/BECN1/NDUFA4/NDUFS7/KIF5A/COX2/NDUFA3/CALM2/CALM3/FIG4/PSMA5/NDUFA11/MAPK8/NDUFA6/DKK1/DAXX/COX8A/LRRK2/UBC/SLC25A31/MAP2K3/NOX1/CAT/RAB8A/TNFRSF1A/DNAH9/XBP1/NDUFV1/WNT1/TUBA1C/CALML5/UBE2G2/CALML4/DNAI1/UCHL1/MAPK9/SLC25A4/RAB1A/NDUFA8/BID/NOS1/ATP6/NDUFA2/DNAH5/COX5B/WIPI2/FASLG/WNT2B/COX6B2/CAMK2G/CASP9/OPTN/TUBA1A/MAP1LC3A/PSMB5/PPP3CA/CTNNB1/PPID/PSMB4/UQCRQ/COX6A1/NDUFA13/CALML3/CYC1/CALML6/NDUFB1/CAPN2/AXIN1/GRIN2B/VAPB/APC/NDUFA7/DCTN3/RAC1/ATG14/APC2/WNT9B/CDK5/PIK3C3/AGER/HTRA2/COX7A1/PSMB2/PSMC6/GPX5/PRKCA/PSMD11/CALM1/MFN2/RYR3/TUBA1B/PSMD1/STX1A/ULK1/BAX/UQCRFS1/NDUFB2/APAF1/C9orf72/NDUFB10/SNCAIP/MAP1LC3C/SDHB/BAD/DNAI2/NDUFS6/PSMD2/NDUFS3/ND4/SPTBN2/GRIN1/FZD3/MFN1/SLC25A6/NDUFV3/ZFYVE1/CACNA1F/UBE2L3/FZD7/CAPN1/ATG13/NOX4/DNAH10/PARK7/PSMA1/WNT3/GRIN2A/TNFRSF1B/CHRM5/ATXN1L/FZD10/TUBA3C/TUBA3D/PSEN2/TUBB6/PLCB4/CHRM1/FZD6/BCL2/NOS2/SLC25A5/UQCRC1/PSMB6/DNAL1/VDAC1/DNAH6/MAP2K2/PSMD3/WNT5A/PRKCG/DNAH8/ATXN3/NDUFA9/TUBB2A/FZD4/PSMA7/DLG4/FZD8/NDUFS4/CSNK1A1/GPX7/HTT/DKK4/NDUFB5/LRP6/ATF4/HIP1/UQCRC2/TRAF2/GNAQ/RB1CC1/WNT11/BDNF/MAP1LC3B2/ATP2A1/GRM5/DNALI1/PSMC5/CACNA1C/PSMA4/NDUFA4L2/ITPR3/IL1B/ERN1/TUBA4A/CSF1/PPP3CB/ADRM1/PSMD9/RAB39B/CACNA1D/COX7A2L/UQCR11/CASP12/NDUFB9/WNT9A/PSMA8/SQSTM1/NEFH/NEFM/NDUFV2/NDUFB8/CHRM3/PTGS2/WNT7B/UBE2L6/CAMK2D/KIF5C/GRIA4/EIF2S1/TARDBP/ATG101/PLCB2/PSMC3/RYR2/WNT8B/NDUFS1/NEFL/GRIN2C/MAPT/ATXN3L/TUBB4A/DDIT3/NDUFS2/PSMD12/NDUFB4/GRIA2/ACTR1A/ITPR1/COX6B1/TUBB3/EIF2AK3/MAPK1/ATXN1/TANK/DNAH14/PPIF/GRIN2D/DCTN5/AXIN2/MAPK3/TUBB4B/WNT7A/PSMA2/PSMD4/MAPK14/VDAC2/ACTR1B/NDUFB3/MAP2K1/DKK2/COX5A/CSNK2A2/TUBA8/WNT5B/IL1A/BAK1/PSMB7/TUBB/KLC4/MAP2K7/APP/LRP5/DCTN4/MAPK13/ATG2A/PSMD8/WNT4/DVL1/PRNP/PPP3R1/FAS/RPS27A/HSPA5/TUBAL3/NFKB1/IL6/NDUFAB1/MCU/PLCB1/CAMK2B/VDAC3/COX8C/WNT10A/BCL2L1	375
KEGG	hsa04927	Cortisol synthesis and secretion	57/5985	65/8135	0.004592	0.03408	0.02331	ATF6B/ATF2/SP1/ITPR2/ADCY6/CREB5/CACNA1H/PLCB3/ADCY7/KCNK3/CREB3L3/STAR/PBX1/CREB3/KCNA4/CREB3L4/SCARB1/NR0B1/ADCY9/ORAI1/ADCY8/GNA11/PRKACA/LDLR/MC2R/POMC/PDE8B/CACNA1G/CACNA1F/CREB1/PLCB4/CYP11A1/NR5A1/ATF4/GNAQ/AGT/CACNA1C/ITPR3/HSD3B1/NCEH1/CACNA1D/AGTR1/KCNK2/ADCY5/PRKACB/CREB3L1/PLCB2/CYP17A1/MRAP/ITPR1/PDE8A/CACNA1I/NR4A1/ADCY3/CYP11B1/PLCB1/PRKACG	57
KEGG	hsa04910	Insulin signaling pathway	114/5985	137/8135	0.004953	0.03596	0.0246	HRAS/ARAF/SHC1/PTPN1/PRKAR2B/KRAS/MKNK1/BRAF/PPP1CC/RHEB/PRKAR2A/AKT2/GSK3B/PPP1CB/RAF1/SOCS4/SOCS3/SH2B2/INPPL1/MKNK2/NRAS/RPS6KB2/EIF4E/SOS2/HK1/PHKG1/MTOR/PDPK1/EXOC7/CALM2/CALM3/PRKAG3/PYGL/MAPK8/SOCS1/RPS6KB1/PPARGC1A/PPP1R3D/CALML5/PHKB/CALML4/MAPK9/IRS1/CRK/PIK3CB/TSC1/HK3/PTPRF/CALML3/CALML6/INS/PRKCZ/FASN/PPP1R3F/CALM1/PRKACA/RPTOR/TSC2/FBP1/BAD/PPP1R3B/GRB2/AKT3/EIF4EBP1/PPP1R3C/ACACB/RHOQ/PIK3CD/G6PC2/PRKAR1B/MAP2K2/G6PC3/PIK3R3/RAPGEF1/SHC3/PRKAG1/SREBF1/PPP1CA/GYS1/PRKAB1/PCK2/PHKA1/PKLR/GCK/FOXO1/LIPE/GYS2/PRKACB/ACACA/PIK3R2/PHKG2/FBP2/MAPK1/SORBS1/PIK3CA/AKT1/IRS2/PRKCI/MAPK3/PRKAA1/FLOT1/MAP2K1/HK2/TRIP10/PHKA2/PYGM/ELK1/PDE3B/SHC2/CBLB/SOS1/G6PC/PRKACG/FLOT2	114
KEGG	hsa04929	GnRH secretion	56/5985	64/8135	0.00553	0.0393	0.02688	HRAS/KRAS/AKT2/ITPR2/KCNN1/RAF1/CACNA1H/NRAS/CGA/PLCB3/ESR2/HCN1/KCNJ6/GABBR1/GPER1/PIK3CB/KCNJ9/TRPC5/GNA11/PRKCA/GABBR2/KISS1/AKT3/KCNN3/CACNA1G/CACNA1F/HCN2/PIK3CD/PLCB4/MAP2K2/KISS1R/KCNJ3/PIK3R3/PRKCG/GNAQ/CACNA1C/ITPR3/CACNA1D/KCNN2/TRPC1/PLCB2/PIK3R2/HCN3/ARRB2/GNRH1/ITPR1/MAPK1/PIK3CA/AKT1/MAPK3/SPP1/CACNA1I/MAP2K1/LHB/ARRB1/PLCB1	56
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	158/5985	194/8135	0.006084	0.04234	0.02895	TP53/GNG2/PIK3R5/HRAS/ZFP36/IFNA10/UBB/MAPKAPK2/KRAS/IFNA16/NFKBIA/CLEC2B/IFNA14/GNG11/GNG4/JUN/CDK6/JAK1/TRADD/AKT2/UBA52/IFNA17/HLA-C/HLA-G/GSK3B/FADD/CCR3/ITPR2/ANGPT2/RAF1/PPP3CC/NFATC4/NRAS/MICB/CSF2/HLA-E/IFNA13/MTOR/GNB2/MAP1LC3B/BECN1/IRF3/HLA-A/CALM2/CALM3/IL6ST/MAPK8/PREX1/GNG5/HLA-B/UBC/CCR1/CREBBP/TNFRSF1A/IFNA4/HCK/SYK/GNG10/HLA-F/CCR5/CALML5/MAP2K4/CHUK/MICA/CALML4/MAPK9/PIK3CB/BID/IFNA7/GNGT1/IRF7/IKBKG/IFNGR1/STAT2/CASP9/MAP1LC3A/PPP3CA/CTNNB1/LYN/CALML3/IFNAR1/CALML6/GNG7/RAC1/ATG14/PIK3C3/TCF7L1/CALM1/SRC/GNG8/BAX/MAP1LC3C/HIF1A/AKT3/CD86/CDK4/E2F3/CREB1/RB1/NFATC2/IFNA1/PIK3CD/GNG13/FGF2/MAP2K2/CXCL1/EP300/IKBKE/PIK3R3/CXCL2/IFNA5/STAT1/TRAF2/PLCG2/MAP1LC3B2/CXCL3/GNG3/ITPR3/TICAM1/PPP3CB/TYK2/IFNA8/FOS/IFNA6/TRAF3/PTGS2/RCAN1/EIF2AK2/IFNA21/PIK3R2/STAT3/JAK2/CCR4/IFNA2/ITPR1/PIK3CG/CXCL8/PIK3R6/MAPK1/PIK3CA/AKT1/IFNAR2/GNG12/CDKN1A/MAPK3/MAPK14/CCR8/MAP2K1/IRF9/BAK1/MAP2K7/MAPK13/PPP3R1/FAS/RPS27A/NFKB1/GNB4/IL6	158
KEGG	hsa00620	Pyruvate metabolism	42/5985	47/8135	0.006971	0.0468	0.03201	ALDH9A1/ALDH1B1/HAGH/MDH2/PDHA1/FH/ACAT1/PKM/ADH1B/ACSS1/ALDH2/MDH1/GLO1/ADH4/DLD/LDHD/ACACB/AKR1A1/PC/ACYP1/ADH5/ACSS2/ALDH3A2/ADH7/ME1/ALDH7A1/LDHA/GRHPR/PCK2/PKLR/ACACA/LDHB/ADH1A/LDHAL6A/ADH6/ME2/PDHA2/ME3/ACOT12/LDHAL6B/ADH1C/DLAT	42
KEGG	hsa05171	Coronavirus disease - COVID-19	187/5985	232/8135	0.007125	0.0468	0.03201	RPL27A/RPL38/RPLP2/NFKBIB/RPS11/TMPRSS2/RPS27L/RPL23/RPL39/IFNA10/RPL34/EGFR/IFNA16/RPL10/NFKBIA/IFNA14/RPL41/JUN/C7/RPL36A/C8G/F13A1/RSL24D1/JAK1/UBA52/RPL22L1/IFNA17/RPL26L1/TRAF6/RPS3A/RPL37A/MAS1/VWF/SELP/RPL21/RPL17/RPL17-C18orf32/RPS2/IL6R/IRAK4/RPL36A-HNRNPH2/RPS7/CSF2/IFNA13/C4A/C4B/CFD/CFB/IRF3/MX2/TLR8/TLR2/MYD88/RPL9/IL6ST/MAPK8/MAP3K7/RPL18A/TNFRSF1A/C6/IFNA4/SYK/MAVS/RPS25/CHUK/MX1/IFIH1/RPL27/MAPK9/PIK3CB/IFNA7/FGG/IKBKG/RPL24/STAT2/RPL36AL/RPL30/RPLP1/IFNAR1/RPL15/RPS17/RPL22/TLR7/TLR4/RPL7/RPS10-NUDT3/PRKCA/CSF3/ADAR/C5AR1/RPLP0/RPL35/ISG15/FGA/RPL18/OAS1/RPL13/CXCL10/FAU/RPS21/RPL6/IFNA1/PIK3CD/RPS5/RPS9/CASP1/F2/ACE/CCL2/IL2/RPL11/IKBKE/PIK3R3/PRKCG/IFNA5/RPL5/RPL29/C8B/RPL7A/STAT1/NRP1/RPS19/PLCG2/IL1B/RPS20/TYK2/IFNA8/FOS/F13B/RPL35A/RPL23A/AGTR1/RPS4X/IFNA6/MBL2/TRAF3/RPS15/C8A/RPS3/RPS13/RPS26/C1QC/EIF2AK2/IFNA21/RPS14/RPL19/PIK3R2/RPL28/RPS10/C3AR1/STAT3/TAB2/RPL10L/C2/MMP1/IFNA2/DDX58/CXCL8/RPL31/RPS15A/MAPK1/PIK3CA/FCGR2A/IFNAR2/RPS23/RPL3L/IRAK1/MASP2/C5/RPS29/MAPK3/OAS3/MAPK14/RPS12/IRF9/MMP3/ACE2/LOC102723407/MAPK13/FGB/RPS27A/RPL12/OAS2/NFKB1/RPS28/IL6/IL12A	187
KEGG	hsa04015	Rap1 signaling pathway	170/5985	210/8135	0.00727	0.0468	0.03201	PFN1/HRAS/EGFR/KRAS/BRAF/ITGB1/RASGRP2/AKT2/RAPGEF5/ACTG1/VASP/EGF/ADCY6/FGF8/ANGPT2/RAF1/FPR1/ACTB/EFNA1/NRAS/FGFR4/FGFR3/PLCB3/ADCY7/FGF3/SIPA1L3/TEK/FLT4/DRD2/TLN2/FGF4/ITGB3/CALM2/CALM3/MAP2K3/RALB/APBB1IP/PDGFA/ANGPT1/CALML5/CALML4/FGF23/ID1/CRK/IGF1R/PIK3CB/FGF16/PARD3/CTNNB1/SIPA1/RASSF5/CALML3/CALML6/INS/GRIN2B/ADCY9/PRKCZ/ARAP3/RAC1/ITGA2B/ADCY8/FLT1/PRKCA/CALM1/CDC42/PARD6B/MET/FGF9/SRC/NGF/VAV1/FGF18/PDGFC/FGF19/SIPA1L2/FGF20/PFN2/FGFR1/RAP1GAP/ADORA2B/RAPGEF6/AKT3/KIT/GRIN1/LPAR1/PARD6A/PLCE1/GRIN2A/PDGFRA/F2R/FGF1/RAP1A/RAPGEF2/PARD6G/PIK3CD/HGF/PLCB4/EVL/FGF2/RHOA/RASGRP3/RAC3/FGF22/ANGPT4/ITGAL/ADORA2A/LPAR5/MAP2K2/PRKD2/RGS14/LPAR2/PIK3R3/PRKCG/RAPGEF1/CDH1/KRIT1/ITGAM/ITGB2/EFNA3/GNAQ/KITLG/EPHA2/SIPA1L1/FGF21/RAC2/CSF1/PRKD1/RAP1B/PGF/PDGFD/ADCY5/VAV2/GNAI2/MAGI3/DOCK4/PLCB2/GNAI3/MAGI1/PIK3R2/VAV3/FGF17/VEGFC/SKAP1/MAPK1/PIK3CA/AKT1/CNR1/CSF1R/P2RY1/PRKCI/NGFR/MAPK3/FGF5/MAPK14/BCAR1/GNAO1/MAP2K1/LCP2/ENAH/THBS1/RAPGEF4/PRKD3/MAPK13/TIAM1/ADCY3/RALA/PLCB1/LPAR4/EFNA4/VEGFB	170
KEGG	hsa05014	Amyotrophic lateral sclerosis	288/5985	364/8135	0.007286	0.0468	0.03201	PFN1/DCTN1/TP53/SRSF3/FUS/PSMD7/PSMA3/SPG11/SDHC/ND3/DCTN2/TUBB1/COX7B/ND6/AMBRA1/TPR/NUP160/NUP210L/UBQLN1/NDUFA10/ATXN2L/COX6C/NCBP1/ANXA11/RAB5A/UQCRB/COX7C/KLC3/SIGMAR1/PIK3R4/DNAH1/DCTN6/SDHD/GPX1/NDUFA1/UBQLN3/ATG2B/ND2/DNAH17/ACTG1/NDUFB7/PSMB3/HNRNPA2B1/NDUFB6/ANXA7/PPP3CC/HAP1/PINK1/COX3/ACTB/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NDUFS5/SMCR8/NRBF2/HNRNPA3/GPX2/VCP/MAP3K5/NUP88/RAE1/PSMC2/KLC1/GPX3/COX1/MTOR/PRPH/CCS/PSMB1/ATF6/TOMM40/UBQLN4/UQCR10/ACTR10/DNAL4/MAP1LC3B/NUP188/POM121/BECN1/NDUFA4/NDUFS7/KIF5A/COX2/NDUFA3/NUP50/FIG4/PSMA5/NDUFA11/NDUFA6/NRG4/SEC13/DAXX/COX8A/MAP2K3/RANBP2/CAT/RAB8A/TNFRSF1A/MATR3/DNAH9/XBP1/NDUFV1/TUBA1C/DNAI1/RAB1A/NDUFA8/BID/NOS1/ATP6/NDUFA2/DNAH5/NXF1/SETX/COX5B/WIPI2/NXF2/NXF2B/COX6B2/CASP9/OPTN/TUBA1A/MAP1LC3A/PSMB5/PPP3CA/HNRNPA1/PSMB4/UQCRQ/COX6A1/NDUFA13/CYC1/NDUFB1/GRIN2B/POM121C/NUP133/VAPB/NDUFA7/DCTN3/RAC1/ATG14/PIK3C3/COX7A1/PSMB2/PSMC6/GPX5/PSMD11/TUBA1B/PSMD1/CHCHD10/NUP37/UBQLN2/ULK1/BAX/UQCRFS1/NDUFB2/APAF1/PFN2/NUP155/C9orf72/NUP54/NDUFB10/MAP1LC3C/SDHB/BAD/DNAI2/NDUFS6/PSMD2/NUP85/NDUFS3/ND4/GRIN1/NDUFV3/ATG13/DNAH10/PSMA1/GRIN2A/TNFRSF1B/TUBA3C/TUBA3D/NUP107/TUBB6/NRG1/BCL2/CASP1/ANG/NOS2/UQCRC1/PSMB6/NRG2/POM121L2/DNAL1/VDAC1/DNAH6/PSMD3/NUP62/NXT1/ALYREF/DNAH8/NDUFA9/TUBB2A/PSMA7/NDUFS4/SLC1A2/GPX7/NDUFB5/NUP35/ATF4/UQCRC2/TRAF2/RB1CC1/MAP1LC3B2/DNALI1/PSMC5/PSMA4/NDUFA4L2/ITPR3/ERN1/TUBA4A/PPP3CB/ADRM1/PSMD9/RAB39B/COX7A2L/UQCR11/CASP12/NDUFB9/PSMA8/SQSTM1/NEFH/NUP205/NEFM/NDUFV2/NDUFB8/HNRNPA1L2/KIF5C/EIF2S1/TARDBP/ATG101/PSMC3/NDUFS1/NEFL/GRIN2C/TUBB4A/DDIT3/NDUFS2/PSMD12/NDUFB4/GRIA2/ACTR1A/COX6B1/ERBB4/TUBB3/EIF2AK3/TANK/DNAH14/GRIN2D/DCTN5/TUBB4B/PSMA2/PSMD4/MAPK14/ACTR1B/NDUFB3/COX5A/TUBA8/NUP214/NXF3/NUP93/NUP210/SEH1L/NUP153/PSMB7/TUBB/KLC4/DCTN4/MAPK13/ATG2A/PSMD8/PPP3R1/HSPA5/TUBAL3/HDAC6/NDUFAB1/MCU/COX8C/BCL2L1	288
KEGG	hsa05017	Spinocerebellar ataxia	118/5985	143/8135	0.007486	0.04718	0.03226	PSMD7/PSMA3/ATP2A3/AMBRA1/ATXN2L/PIK3R4/AKT2/ATG2B/SP1/PSMB3/TBP/ITPR2/PSMD6/ATXN8OS/PSMC4/NFYA/NRBF2/ATP2A2/PLCB3/MAP3K5/PSMC2/MTOR/RBPJ/GRM1/PSMB1/GRIN3A/PUM2/BECN1/PSMA5/MAPK8/SLC25A31/XBP1/SLC1A6/MAPK9/SLC25A4/PIK3CB/RELN/WIPI2/PSMB5/PSMB4/GRIN2B/ATXN10/KAT5/ATG14/PIK3C3/PSMB2/PSMC6/PRKCA/PSMD11/PSMD1/ULK1/PSMD2/AKT3/SPTBN2/GRIN1/SLC25A6/ATG13/CACNA1A/PSMA1/VLDLR/RBPJL/GRIN2A/PIK3CD/ATXN1L/PLCB4/SLC25A5/PSMB6/TBPL1/VDAC1/PSMD3/GTF2B/PIK3R3/PRKCG/MYOD1/DAB1/ATXN3/KCNC3/PSMA7/NOP56/TRAF2/GNAQ/RB1CC1/ATP2A1/PSMC5/PSMA4/ITPR3/ERN1/ADRM1/PSMD9/PSMA8/ATG101/PLCB2/PSMC3/PIK3R2/GRIN2C/ATXN3L/KCND3/PSMD12/GRIA2/ITPR1/OPA1/OMA1/RORA/PIK3CA/AKT1/ATXN1/PPIF/GRIN2D/AFG3L2/PSMA2/PSMD4/VDAC2/PSMB7/ATG2A/PSMD8/MCU/PLCB1/VDAC3	118
KEGG	hsa05205	Proteoglycans in cancer	166/5985	205/8135	0.007772	0.04796	0.0328	TP53/HRAS/ARAF/PTPN11/MDM2/FZD2/EGFR/KRAS/ANK1/MSN/BRAF/MMP2/ITGB1/COL1A1/PPP1CC/ITGB5/AKT2/WNT2/ACTG1/EZR/SMO/ITPR2/EIF4B/CTTN/PPP1CB/RAF1/ACTB/MMP9/NRAS/RPS6KB2/FRS2/SOS2/CAV3/RDX/MTOR/PDPK1/HPSE/GPC1/WNT8A/MIR21/ITGB3/PDCD4/TLR2/CD44/ROCK1/RPS6KB1/ITGA5/ARHGEF12/CAV1/WNT1/PPP1R12C/PTK2/TWIST1/COL1A2/CAV2/ROCK2/IGF1R/PIK3CB/SHH/SDC4/HSPG2/FASLG/VTN/WNT2B/CAMK2G/ARHGEF1/CTNNB1/ERBB2/TLR4/RAC1/WNT9B/PAK1/PRKCA/CDC42/MET/SRC/VAV1/PRKACA/FGFR1/IQGAP1/HIF1A/GRB2/AKT3/FZD3/FZD7/SMAD2/PLCE1/HSPB2/WNT3/PIK3CD/FZD10/ESR1/HGF/FZD6/FGF2/RHOA/HCLS1/MAP2K2/WNT5A/TGFB1/PIK3R3/PRKCG/FLNB/FZD4/FZD8/GAB1/GPC3/NUDT16L1/ANK3/PLCG2/WNT11/ITPR3/PPP1CA/MIR10A/PLAUR/HOXD10/WNT9A/PXN/LUM/VAV2/SDC2/FN1/WNT7B/CAMK2D/PPP1R12B/FLNC/PRKACB/WNT8B/SLC9A1/PIK3R2/STAT3/VAV3/CD63/CTSL/ITPR1/ERBB4/MAPK1/PIK3CA/AKT1/ERBB3/TFAP4/ANK2/CDKN1A/DDX5/MAPK3/ITGA2/WNT7A/MAPK14/MAP2K1/PTCH1/DCN/WNT5B/NANOG/THBS1/ELK1/HPSE2/MAPK13/IHH/WNT4/TIAM1/FAS/SOS1/PTPN6/CAMK2B/PRKACG/WNT10A	166
KEGG	hsa05224	Breast cancer	121/5985	147/8135	0.008	0.04796	0.0328	TP53/HRAS/ARAF/SHC1/DVL3/FZD2/EGFR/KRAS/NFKB2/JUN/BRAF/CDK6/AKT2/WNT2/SP1/GSK3B/EGF/FRAT2/FGF8/RAF1/FRAT1/NRAS/RPS6KB2/SOS2/FGF3/BRCA1/MTOR/FLT4/ESR2/WNT8A/FGF4/RPS6KB1/WNT1/FGF23/IGF1R/PIK3CB/FGF16/GADD45A/WNT2B/CTNNB1/ERBB2/HEY2/AXIN1/DLL1/APC/APC2/WNT9B/TCF7L1/FGF9/FGF18/FGF19/FGF20/BAX/NCOA1/FGFR1/GRB2/AKT3/KIT/FZD3/FZD7/CDK4/E2F3/WNT3/RB1/FGF1/PIK3CD/FZD10/NCOA3/ESR1/FZD6/FGF2/FGF22/MAP2K2/WNT5A/PIK3R3/POLK/FZD4/PTEN/GADD45B/SHC3/FZD8/NOTCH1/PGR/CSNK1A1/LRP6/WNT11/DDB2/HES5/FGF21/FOS/WNT9A/NOTCH2/HES1/WNT7B/WNT8B/PIK3R2/FGF17/DLL4/HEY1/NOTCH4/MAPK1/PIK3CA/AKT1/CDKN1A/AXIN2/MAPK3/WNT7A/DLL3/FGF5/TNFSF11/MAP2K1/HEYL/WNT5B/NOTCH3/BAK1/LRP5/SHC2/WNT4/DVL1/SOS1/WNT10A	121
KEGG	hsa00010	Glycolysis / Gluconeogenesis	58/5985	67/8135	0.008041	0.04796	0.0328	ALDH9A1/PGAM2/ALDH1B1/PDHA1/HK1/PGAM1/PGM1/PKM/BPGM/ENO3/ADH1B/ACSS1/TPI1/MINPP1/HK3/GAPDH/ALDH2/ALDOA/ALDH3B1/ADH4/DLD/FBP1/ENO1/PGK1/PFKM/PGM2/AKR1A1/GALM/G6PC2/ADH5/ACSS2/ALDOC/G6PC3/ALDH3A2/PGK2/ADH7/ALDH7A1/ALDH3A1/LDHA/GAPDHS/ENO2/PCK2/PKLR/GCK/GPI/FBP2/LDHB/ADH1A/LDHAL6A/ADH6/ADPGK/PDHA2/HK2/PFKP/LDHAL6B/ADH1C/G6PC/DLAT	58
KEGG	hsa04934	Cushing syndrome	127/5985	155/8135	0.009033	0.05293	0.0362	ATF6B/KMT2D/ATF2/DVL3/FZD2/EGFR/BRAF/ARNT/CDK6/WNT2/RBBP5/SP1/GSK3B/ITPR2/ADCY6/CREB5/CDKN1B/CACNA1H/AIPL1/PLCB3/ADCY7/FH/KCNK3/CREB3L3/WNT8A/STAR/PBX1/CREB3/KCNA4/CCNE2/CREB3L4/WNT1/WNT2B/SCARB1/KMT2A/CAMK2G/CTNNB1/AXIN1/ADCY9/APC/ORAI1/APC2/WNT9B/ADCY8/GNA11/TCF7L1/PRKACA/LDLR/MC2R/POMC/ARMC5/FZD3/PDE8B/CACNA1G/CACNA1F/FZD7/CDK4/E2F3/WNT3/CREB1/RB1/AIP/RAP1A/FZD10/PLCB4/FZD6/USP8/MAP2K2/WNT5A/CYP11A1/MEN1/CDK2/FZD4/FZD8/NR5A1/ATF4/GNAQ/WNT11/CRHR2/AGT/CACNA1C/ITPR3/AHR/HSD3B1/NCEH1/RAP1B/CACNA1D/AGTR1/WNT9A/KCNK2/ADCY5/CDKN2B/CDKN2C/WNT7B/GNAI2/CAMK2D/PRKACB/CREB3L1/PLCB2/WNT8B/GNAI3/CYP17A1/RASD1/MRAP/ITPR1/MAPK1/CDKN1A/AXIN2/MAPK3/WNT7A/PDE8A/CACNA1I/MAP2K1/PDE11A/WNT5B/NR4A1/ASH2L/CCNE1/WNT4/DVL1/ADCY3/CDKN2A/CYP11B1/PLCB1/CAMK2B/PRKACG/WNT10A	127
KEGG	hsa04210	Apoptosis	112/5985	136/8135	0.01023	0.0589	0.04028	TP53/MCL1/HRAS/CASP2/KRAS/NFKBIA/SPTAN1/JUN/TRADD/AKT2/ACTG1/FADD/ITPR2/RAF1/PARP4/ACTB/NRAS/XIAP/MAP3K5/CSF2RB/TNFSF10/CFLAR/PDPK1/BCL2L11/CTSS/CTSO/MAPK8/IL3/TNFRSF10B/DAXX/SPTA1/CTSB/DFFA/PARP1/TNFRSF1A/CASP6/TUBA1C/CHUK/MAPK9/PIK3CB/BID/IKBKG/NTRK1/FASLG/GADD45A/TRAF1/CASP9/TUBA1A/LMNB2/CAPN2/HTRA2/TUBA1B/GZMB/NGF/PMAIP1/BAX/APAF1/BAD/AKT3/PIDD1/CAPN1/ATM/PIK3CD/TUBA3C/TUBA3D/CTSH/CTSK/BCL2/MAP2K2/PIK3R3/GADD45B/CTSC/ATF4/TRAF2/CASP10/ITPR3/ERN1/TUBA4A/FOS/PARP3/PRF1/CASP12/CTSD/IL3RA/EIF2S1/DAB2IP/PIK3R2/CTSV/PARP2/CTSL/DDIT3/DFFB/ITPR1/EIF2AK3/MAPK1/PIK3CA/AKT1/AIFM1/DIABLO/MAPK3/BCL2A1/MAP2K1/TUBA8/TNFRSF10A/LMNB1/BAK1/FAS/BIRC5/TUBAL3/NFKB1/BCL2L1/BIRC3	112
KEGG	hsa04725	Cholinergic synapse	94/5985	113/8135	0.0105	0.0589	0.04028	GNG2/PIK3R5/HRAS/KRAS/GNG11/GNG4/CHRM2/AKT2/ITPR2/ADCY6/KCNJ2/CREB5/NRAS/PLCB3/ADCY7/GNB2/CREB3L3/SLC5A7/GNG5/CREB3/KCNJ6/CREB3L4/GNG10/PIK3CB/GNGT1/KCNQ4/CAMK2G/CHRNB4/GNG7/ADCY9/ADCY8/GNA11/KCNJ4/PRKCA/CHRNA4/GNG8/PRKACA/AKT3/CHRNB2/SLC18A3/CACNA1F/CACNA1A/KCNQ3/CREB1/PIK3CD/CHRM5/GNG13/PLCB4/CHRM1/BCL2/KCNJ3/PIK3R3/PRKCG/KCNQ5/ATF4/KCNJ12/KCNJ18/GNAQ/GNG3/CHRNA3/CACNA1C/ITPR3/CHRM4/FYN/FOS/CACNA1D/ADCY5/CHRM3/KCNQ2/GNAI2/KCNQ1/CAMK2D/PRKACB/CREB3L1/PLCB2/GNAI3/PIK3R2/JAK2/ITPR1/PIK3CG/PIK3R6/MAPK1/PIK3CA/AKT1/GNG12/MAPK3/GNAO1/MAP2K1/ADCY3/GNB4/PLCB1/CAMK2B/PRKACG/ACHE	94
KEGG	hsa04022	cGMP-PKG signaling pathway	136/5985	167/8135	0.01058	0.0589	0.04028	ATF6B/PIK3R5/ATP2A3/ATF2/PLN/ATP1B3/MYLK4/MYH6/PPP1CC/MYH7/MEF2D/AKT2/MYLK3/VASP/SLC8A3/ADRA1B/ITPR2/ADCY6/NPPB/PPP1CB/RAF1/PPP3CC/CREB5/KCNMB2/NFATC4/NOS3/ATP2A2/SRF/PLCB3/ADCY7/PRKG1/NPPC/CREB3L3/ADRA2C/CALM2/CALM3/ROCK1/CREB3/KCNMB4/ADRA2B/SLC25A31/CREB3L4/GNA13/MYLK/CNGA1/CALML5/CALML4/SLC25A4/IRS1/ROCK2/MEF2C/PPP3CA/ATP1B2/CALML3/CALML6/INS/ADRA2A/ADCY9/ATP1A3/MRVI1/ADCY8/GNA11/CALM1/ADRA1D/NPR1/SLC8A2/KNG1/BAD/ADORA3/ATP1A1/AKT3/KCNU1/SLC25A6/CACNA1F/EDNRB/RGS2/GTF2I/GNA12/GUCY1A2/CREB1/NFATC2/PDE5A/PLCB4/RHOA/SLC25A5/VDAC1/MAP2K2/ATP2B3/MYL9/TRPC6/ATF4/GNAQ/GTF2IRD1/ATP2A1/ATP2B4/CACNA1C/ATP2B2/ITPR3/EDNRA/KCNMB1/PPP3CB/PPP1CA/CNGB1/PDE3A/ADORA1/CACNA1D/AGTR1/ADCY5/ATP2B1/MYLK2/GNAI2/ADRB2/ATP1A2/CREB3L1/PLCB2/GNAI3/ITPR1/PIK3CG/PIK3R6/MAPK1/AKT1/IRS2/PPIF/ADRB1/MAPK3/VDAC2/MAP2K1/KCNJ8/KCNMB3/PRKCE/PDE3B/ADCY3/PPP3R1/PLCB1/VDAC3/PDE2A	136
KEGG	hsa05110	Vibrio cholerae infection	44/5985	50/8135	0.01101	0.06029	0.04123	ACTG1/ATP6V1B2/KDELR1/TJP2/ATP6V0C/ATP6V0E1/ACTB/ATP6V0D2/SEC61A2/ATP6V0B/KDELR3/ATP6V1C2/ATP6V1G3/SEC61G/ATP6V1H/ATP6V0D1/ATP6V1E1/ATP6V1E2/ADCY9/ATP6V1A/ATP6V1F/PRKCA/ATP6V1C1/ATP6AP1/PRKACA/PDIA4/ATP6V1B1/SLC12A2/SEC61A1/PLCG2/KDELR2/ARF1/TJP1/KCNQ1/PRKACB/SEC61B/ATP6V0E2/ATP6V0A1/ATP6V1G2/ATP6V1D/ATP6V1G1/ADCY3/PRKACG/TCIRG1	44
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	117/5985	143/8135	0.01303	0.06951	0.04754	JAK3/HRAS/PCGF3/DVL3/FZD2/KRAS/HOXD1/ACVR2A/SMAD3/JAK1/AKT2/INHBC/MEIS1/WNT2/GSK3B/PCGF1/RAF1/ACVR1/NRAS/FGFR4/SMAD4/FGFR3/NEUROG1/ID3/ZIC3/REST/SKIL/WNT8A/LHX5/IL6ST/LIF/HAND1/WNT1/HOXB1/RIF1/KAT6A/LEFTY1/HESX1/ID1/IGF1R/PIK3CB/ACVR1C/WNT2B/PCGF2/CTNNB1/TCF3/AXIN1/APC/APC2/WNT9B/SOX2/FGFR1/ESX1/GRB2/AKT3/ZFHX3/FZD3/FZD7/SMAD2/ESRRB/WNT3/PIK3CD/PCGF6/FZD10/ID4/FZD6/FGF2/SMARCAD1/MAP2K2/SETDB1/WNT5A/JARID2/PIK3R3/INHBE/FZD4/FZD8/ONECUT1/DLX5/WNT11/BMP4/INHBA/LEFTY2/OTX1/WNT9A/TBX3/SMAD1/POU5F1/WNT7B/PCGF5/ACVR1B/WNT8B/PIK3R2/BMPR1B/STAT3/ISL1/JAK2/MAPK1/PIK3CA/AKT1/AXIN2/SMAD5/MAPK3/WNT7A/DUSP9/MAPK14/MYF5/ACVR2B/MAP2K1/WNT5B/NANOG/MAPK13/WNT4/DVL1/ID2/PAX6/KLF4/WNT10A	117
KEGG	hsa04270	Vascular smooth muscle contraction	110/5985	134/8135	0.01311	0.06951	0.04754	ARAF/MYH11/BRAF/MYH10/MYLK4/AVPR1B/PPP1CC/MYL6/MYLK3/ADRA1B/ITPR2/ADCY6/NPPB/PPP1CB/RAF1/KCNMB2/PLCB3/ADCY7/PRKG1/NPPC/RAMP3/PTGIR/CALM2/CALM3/EDN2/ROCK1/ADM/KCNMB4/ARHGEF12/PLA2G2D/MYH9/GNA13/PPP1R12C/MYLK/CALML5/AVPR1A/CALML4/AVP/ROCK2/PLA2G1B/PLA2G4F/ACTA2/PLA2G2F/PLA2G2A/ARHGEF1/CALCB/CALML3/MYH14/CALML6/PLA2G4A/ADCY9/PLA2G12A/MRVI1/ADCY8/GNA11/PRKCA/CALM1/ADRA1D/PRKCD/PRKACA/ADORA2B/NPR1/MYL6B/KCNU1/CACNA1F/GNA12/GUCY1A2/PLCB4/RHOA/JMJD7-PLA2G4B/ADORA2A/MAP2K2/PRKCG/MYL9/EDN3/GNAQ/PLA2G2E/AGT/CACNA1C/ITPR3/EDNRA/KCNMB1/PPP1CA/CACNA1D/PLA2G12B/AGTR1/ADCY5/MYLK2/PLA2G3/PRKCQ/PPP1R12B/PRKACB/PLCB2/ITPR1/PLA2G10/MAPK1/PLA2G6/MAPK3/MAP2K1/CALCRL/KCNMB3/PLA2G5/PRKCE/CALD1/RAMP2/ADCY3/PRKCH/PLCB1/PRKACG/ACTG2	110
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	43/5985	49/8135	0.01332	0.06954	0.04756	TSTA3/UGP2/GMPPA/NPL/GNPDA1/CYB5R1/GALE/NAGK/HK1/PGM1/PGM3/FPGT/CYB5RL/HK3/RENBP/UXS1/UGDH/GNPDA2/GMPPB/PMM1/GNPNAT1/HEXB/GNE/GALK1/PGM2/GFPT2/CYB5R4/GMDS/CMAS/GALK2/NANP/PMM2/NANS/GCK/CHIT1/UAP1/GALT/CYB5R3/GPI/CHIA/HK2/HEXA/GFPT1	43
KEGG	hsa04530	Tight junction	137/5985	169/8135	0.01386	0.0712	0.04869	PPP2R1A/NF2/MYL12A/ARPC1B/MPP5/LLGL1/DLG1/RUNX1/ARPC4/MSN/MYH11/JUN/CLDN7/MYH10/ITGB1/PPP2R2D/CLDN17/MYL6/ACTG1/EZR/VASP/WHAMM/CLDN15/CTTN/TJP2/ARHGEF2/ACTR3/ACTB/CLDN3/CLDN20/CLDN19/MAP3K5/CD1A/RDX/ACTN4/ARPC1A/F11R/CD1B/PCNA/EPB41L4B/RAB13/ACTR2/NEDD4L/PRKAG3/CLDN8/MAPK8/PPP2R1B/MPDZ/ROCK1/ARHGEF18/ACTN1/PPP2CA/MYH9/RAB8A/ARPC5L/TUBA1C/IGSF5/JAM3/MAPK9/CD1D/ROCK2/CLDN5/YBX3/SYNPO/LLGL2/CGNL1/TUBA1A/PARD3/ERBB2/CLDN1/MYH14/CD1C/STK11/PRKCZ/RAC1/AMOT/CLDN4/CDC42/PARD6B/TUBA1B/SRC/TJP3/PRKACA/RAPGEF6/SLC9A3R1/MYL6B/BVES/SYMPK/ARPC2/PARD6A/CDK4/HSPA4/CLDN14/RAP1A/RAPGEF2/PARD6G/TJAP1/TUBA3C/TUBA3D/CLDN16/RHOA/HCLS1/ARHGAP17/RAB8B/PPP2R2C/MYL9/CLDN11/CLDN10/PRKAG1/PPP2R2A/SCRIB/TUBA4A/CRB3/CACNA1D/MPP4/PRKAB1/AMOTL2/OCLN/CLDN18/TJP1/PRKACB/MAGI1/MYL12B/MARVELD2/WAS/PRKCI/PRKAA1/CLDN23/TUBA8/PRKCE/ARPC3/MAP2K7/TIAM1/TUBAL3/DLG3/CLDN9/PRKACG	137
KEGG	hsa05330	Allograft rejection	34/5985	38/8135	0.01468	0.07404	0.05064	HLA-C/HLA-G/HLA-E/HLA-A/HLA-B/HLA-F/IL5/CD80/HLA-DPA1/FASLG/HLA-DMB/GZMB/IL4/HLA-DRB1/CD40/HLA-DQA2/HLA-DRA/CD86/HLA-DMA/CD40LG/HLA-DQB1/IL2/IL10/HLA-DOB/HLA-DRB4/IFNG/HLA-DOA/PRF1/HLA-DPB1/HLA-DQA1/LOC102723407/FAS/CD28/IL12A	34
KEGG	hsa04611	Platelet activation	102/5985	124/8135	0.01485	0.07404	0.05064	PIK3R5/MYL12A/MYLK4/ITGB1/COL1A1/RASGRP2/PPP1CC/AKT2/MYLK3/ACTG1/VASP/ARHGAP35/ITPR2/ADCY6/PPP1CB/P2RY12/VWF/NOS3/ACTB/PLCB3/ADCY7/PRKG1/TLN2/TBXAS1/PTGS1/ITGB3/PTGIR/GP1BB/ROCK1/ARHGEF12/SNAP23/APBB1IP/SYK/GNA13/MYLK/GP9/COL1A2/ROCK2/PIK3CB/FGG/PLA2G4F/ARHGEF1/LYN/PLA2G4A/ADCY9/PRKCZ/ORAI1/ITGA2B/ADCY8/GP5/FERMT3/SRC/PRKACA/FGA/BTK/AKT3/GUCY1A2/F2R/RAP1A/FCER1G/PIK3CD/PLCB4/RHOA/F2/JMJD7-PLA2G4B/GP6/PIK3R3/GP1BA/GNAQ/PLCG2/ITPR3/PPP1CA/FYN/RAP1B/ADCY5/MYLK2/GNAI2/P2RX1/PRKACB/PLCB2/GNAI3/PIK3R2/MYL12B/ITPR1/PIK3CG/PIK3R6/MAPK1/PIK3CA/AKT1/FCGR2A/P2RY1/PRKCI/MAPK3/ITGA2/MAPK14/LCP2/MAPK13/FGB/ADCY3/TBXA2R/PLCB1/PRKACG	102
KEGG	hsa04940	Type I diabetes mellitus	38/5985	43/8135	0.0156	0.07661	0.05239	HSPD1/HLA-C/HLA-G/HLA-E/HLA-A/HLA-B/HLA-F/CD80/HLA-DPA1/FASLG/INS/HLA-DMB/GZMB/HLA-DRB1/HLA-DQA2/PTPRN/HLA-DRA/CD86/CPE/HLA-DMA/HLA-DQB1/IL2/HLA-DOB/HLA-DRB4/IFNG/IL1B/HLA-DOA/PRF1/LTA/PTPRN2/HLA-DPB1/HLA-DQA1/IL1A/ICA1/FAS/CD28/IL12A/GAD2	38
KEGG	hsa05140	Leishmaniasis	65/5985	77/8135	0.017	0.08228	0.05627	NFKBIB/NFKBIA/JUN/ITGB1/JAK1/TRAF6/CYBA/ITGA4/IRAK4/NCF1/FCGR3B/TLR2/MYD88/CR1L/TAB1/IFNGR2/MAP3K7/NCF4/NCF2/HLA-DPA1/IFNGR1/TLR4/HLA-DMB/IL4/FCGR3A/HLA-DRB1/HLA-DQA2/CR1/HLA-DRA/MARCKSL1/HLA-DMA/NOS2/HLA-DQB1/TGFB1/IL10/EEF1A2/ITGAM/ITGB2/STAT1/HLA-DOB/HLA-DRB4/IFNG/IL1B/HLA-DOA/FOS/PTGS2/FCGR1A/HLA-DPB1/TAB2/JAK2/MAPK1/FCGR2A/IRAK1/MAPK3/MAPK14/HLA-DQA1/IL1A/EEF1A1/ELK1/TGFB3/LOC102723407/MAPK13/NFKB1/PTPN6/IL12A	65
KEGG	hsa05218	Melanoma	61/5985	72/8135	0.01767	0.08432	0.05767	TP53/HRAS/ARAF/MDM2/EGFR/KRAS/BRAF/CDK6/AKT2/EGF/FGF8/RAF1/NRAS/FGF3/FGF4/PDGFA/FGF23/IGF1R/PIK3CB/FGF16/GADD45A/MITF/MET/FGF9/FGF18/PDGFC/FGF19/FGF20/BAX/FGFR1/BAD/AKT3/CDK4/E2F3/RB1/PDGFRA/FGF1/PIK3CD/HGF/FGF2/FGF22/MAP2K2/PIK3R3/POLK/PTEN/GADD45B/CDH1/DDB2/FGF21/PDGFD/PIK3R2/FGF17/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/FGF5/MAP2K1/BAK1/CDKN2A	61
KEGG	hsa01250	Biosynthesis of nucleotide sugars	33/5985	37/8135	0.01806	0.08484	0.05802	TSTA3/UGP2/GMPPA/GALE/NAGK/MIOX/HK1/PGM1/TGDS/PGM3/FPGT/HK3/UXS1/UGDH/GMPPB/PMM1/GNPNAT1/GNE/GALK1/PGM2/GFPT2/GMDS/CMAS/GALK2/NANP/PMM2/NANS/GCK/UAP1/GALT/GPI/HK2/GFPT1	33
KEGG	hsa05221	Acute myeloid leukemia	57/5985	67/8135	0.01829	0.08484	0.05802	HRAS/ARAF/KRAS/RUNX1/BRAF/PPARD/AKT2/RAF1/NRAS/RPS6KB2/SOS2/DUSP6/CSF2/CCNA2/MTOR/CEBPA/CD14/IL3/RPS6KB1/STAT5B/PML/CHUK/PIK3CB/PER2/IKBKG/TCF7L1/CCNA1/BAD/GRB2/AKT3/KIT/EIF4EBP1/STAT5A/PIK3CD/JUP/PIM1/MAP2K2/PIK3R3/ITGAM/PIM2/FCGR1A/PIK3R2/RARA/RUNX1T1/STAT3/CEBPE/MAPK1/PIK3CA/AKT1/CSF1R/MAPK3/BCL2A1/MAP2K1/SOS1/NFKB1/FLT3/MPO	57
KEGG	hsa04620	Toll-like receptor signaling pathway	86/5985	104/8135	0.01896	0.08673	0.05931	IFNA10/IFNA16/NFKBIA/IFNA14/JUN/AKT2/IFNA17/TRAF6/FADD/TLR6/IRAK4/IFNA13/TLR1/TICAM2/IRF3/CD14/TLR8/TLR2/MYD88/MAPK8/TAB1/MAP3K7/MAP2K3/IFNA4/MAP2K4/CHUK/MAPK9/PIK3CB/CD80/IFNA7/IRF7/IKBKG/IFNAR1/TLR7/TLR4/RAC1/TLR5/CD40/AKT3/CXCL10/CD86/IFNA1/CCL5/PIK3CD/CTSK/MAP2K2/IKBKE/PIK3R3/IRF5/TIRAP/IFNA5/CXCL9/STAT1/TOLLIP/IL1B/TICAM1/TLR9/IFNA8/FOS/LY96/IFNA6/TRAF3/LBP/IFNA21/PIK3R2/TAB2/IFNA2/CXCL8/MAPK1/PIK3CA/AKT1/IFNAR2/IRAK1/MAPK3/CCL3/CCL3L1/CCL3L3/SPP1/MAPK14/MAP2K1/MAP2K7/MAPK13/NFKB1/CCL4/IL6/IL12A	86
KEGG	hsa04072	Phospholipase D signaling pathway	120/5985	148/8135	0.0203	0.0916	0.06265	CYTH1/PIK3R5/HRAS/SHC1/PTPN11/PIP5K1A/EGFR/KRAS/PTK2B/DGKE/CXCR2/AVPR1B/RHEB/AKT2/CXCR1/EGF/ADCY6/RAF1/AGPAT4/CYTH4/NRAS/SOS2/PLCB3/ADCY7/MTOR/DNM2/GRM1/ARF6/AGPAT5/FCER1A/CYTH3/GRM6/SPHK1/SPHK2/AGPAT1/DGKA/DGKK/RALB/SYK/GNA13/PDGFA/AVPR1A/AVP/PIK3CB/TSC1/PLA2G4F/PLA2G4A/PIP5K1C/INS/ADCY9/ADCY8/MS4A2/PRKCA/PDGFC/TSC2/AVPR2/GRB2/GAB2/AKT3/KIT/LPAR1/GNA12/GRM3/PDGFRA/DGKG/F2R/FCER1G/PIK3CD/PIP5K1B/PLCB4/RHOA/F2/JMJD7-PLA2G4B/LPAR5/MAP2K2/LPAR2/GRM2/PLD1/PIK3R3/DGKZ/SHC3/GAB1/PLCG2/KITLG/GRM5/AGT/CYTH2/FYN/PDGFD/AGTR1/ARF1/ADCY5/DGKQ/DNM3/GRM8/PTGFR/PLCB2/PIK3R2/PIK3CG/CXCL8/PIK3R6/MAPK1/PIK3CA/AKT1/MAPK3/GRM7/DGKH/LPAR6/MAP2K1/GRM4/DGKB/AGPAT2/RAPGEF4/LOC102723407/SHC2/ADCY3/SOS1/RALA/PLCB1/LPAR4	120
KEGG	hsa04657	IL-17 signaling pathway	78/5985	94/8135	0.02132	0.09488	0.06489	JUND/FOSB/NFKBIA/MUC5B/CXCL5/JUN/IL17C/TRADD/TRAF6/GSK3B/FADD/MMP9/CSF2/S100A9/LCN2/HSP90AB1/DEFB4A/DEFB4B/TNFAIP3/CEBPB/MAPK8/SRSF1/ANAPC5/MAP3K7/IL17RA/IL17B/CHUK/MAPK9/IL5/IKBKG/TAB3/IL17RE/MAPK6/CSF3/HSP90B1/IL4/CXCL10/MMP13/ELAVL1/MAPK7/CCL17/TRAF4/CCL2/CXCL1/S100A8/IL17D/IKBKE/CXCL2/S100A7/IL17RB/TRAF2/CCL20/CXCL3/IFNG/IL17A/IL1B/HSP90AA1/FOSL1/IL17RC/FOS/TRAF3/IL25/IL17F/PTGS2/TAB2/MMP1/MAPK4/CXCL8/MAPK1/MAPK3/MAPK14/CXCL6/MMP3/USP25/S100A7A/MAPK13/NFKB1/IL6	78
KEGG	hsa05145	Toxoplasmosis	92/5985	112/8135	0.02163	0.09488	0.06489	NFKBIB/PIK3R5/LAMB1/NFKBIA/ITGB1/JAK1/AKT2/IL10RB/TRAF6/XIAP/IRAK4/PDPK1/HSPA1L/HSPA1A/HSPA1B/TLR2/MYD88/MAPK8/TAB1/SOCS1/IFNGR2/HSPA6/MAP3K7/MAP2K3/TNFRSF1A/CCR5/CHUK/MAPK9/HLA-DPA1/IKBKG/IFNGR1/CASP9/LAMC1/TLR4/IRGM/HLA-DMB/LDLR/BAD/HLA-DRB1/CD40/AKT3/HLA-DQA2/ALOX5/HLA-DRA/HLA-DMA/CD40LG/CIITA/LAMB2/BCL2/NOS2/HLA-DQB1/BIRC7/LAMB3/TGFB1/IL10/LAMA2/STAT1/HLA-DOB/HLA-DRB4/IFNG/HLA-DOA/TYK2/LY96/GNAI2/HLA-DPB1/LAMA5/GNAI3/STAT3/TAB2/JAK2/IL10RA/PIK3CG/PIK3R6/MAPK1/AKT1/IRAK1/PPIF/MAPK3/MAPK14/GNAO1/HSPA8/HLA-DQA1/LAMC2/LAMC3/TGFB3/MAPK13/HSPA2/NFKB1/ITGA6/IL12A/BCL2L1/BIRC3	92
KEGG	hsa04150	mTOR signaling pathway	126/5985	156/8135	0.022	0.09488	0.06489	HRAS/STRADB/DVL3/FZD2/KRAS/BRAF/SKP2/RHEB/AKT2/WNT2/GSK3B/ATP6V1B2/EIF4B/RAF1/DDIT4/NRAS/RPS6KB2/EIF4E/SOS2/SLC38A9/FNIP1/MTOR/PDPK1/LAMTOR1/DEPTOR/WNT8A/ATP6V1C2/NPRL3/RRAGA/LPIN2/RPS6KB1/SEC13/ATP6V1G3/TNFRSF1A/WNT1/RRAGD/ATP6V1H/CHUK/MAPKAP1/WDR59/IRS1/IGF1R/PIK3CB/TSC1/WNT2B/ATP6V1E1/ATP6V1E2/GRB10/RPS6KA1/INS/STK11/RPS6KA3/ATP6V1A/ATP6V1F/WNT9B/RRAGC/PRKCA/LAMTOR2/ATP6V1C1/TELO2/ULK1/SLC3A2/RPTOR/TSC2/GRB2/AKT3/FZD3/ATP6V1B1/EIF4EBP1/STRADA/FZD7/WNT3/FNIP2/PIK3CD/FZD10/NPRL2/FZD6/RHOA/AKT1S1/MAP2K2/WNT5A/PIK3R3/PRKCG/FZD4/PTEN/FZD8/RPS6KA6/LRP6/WDR24/FLCN/WNT11/PRR5/CAB39/TBC1D7/WNT9A/WNT7B/SESN2/LAMTOR3/WNT8B/CAB39L/PIK3R2/TTI1/LAMTOR5/MAPK1/PIK3CA/AKT1/MAPK3/WNT7A/SGK1/RPS6KA2/CLIP1/PRKAA1/MAP2K1/WNT5B/SEH1L/MIOS/ATP6V1G2/LRP5/ATP6V1D/WNT4/ATP6V1G1/DVL1/SOS1/LAMTOR4/MLST8/WNT10A	126
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	32/5985	36/8135	0.02216	0.09488	0.06489	NADSYN1/NADK2/SIRT7/NMNAT3/ENPP3/NMNAT1/NT5C2/NT5M/PNP/BST1/NAMPT/AOX1/NNMT/SIRT4/SIRT5/NMNAT2/SIRT1/ASPDH/SIRT2/NADK/CD38/NT5C1B-RDH14/NT5C1B/NNT/NT5C1A/NMRK1/SIRT3/SIRT6/NMRK2/NUDT12/QPRT/NT5C	32
KEGG	hsa03050	Proteasome	40/5985	46/8135	0.02328	0.09841	0.0673	PSMD7/PSMA3/PSME3/PSMB3/PSMB8/PSMD6/PSMC4/PSMC2/PSMB10/PSMB1/PSME1/POMP/PSMA5/PSMB9/PSME4/PSMB5/PSMB4/PSMB2/PSMC6/PSMD11/PSMD1/PSMF1/PSMD2/PSMA1/PSMB6/PSMD3/PSMA7/IFNG/PSMC5/PSMA4/ADRM1/PSMD9/PSMA8/PSME2/PSMC3/PSMD12/PSMA2/PSMD4/PSMB7/PSMD8	40
KEGG	hsa04014	Ras signaling pathway	184/5985	232/8135	0.02436	0.1016	0.06946	GNG2/HRAS/SHC1/PTPN11/EGFR/KRAS/RAB5C/GNG11/GNG4/RAB5A/RASA3/RASGRP2/AKT2/RAPGEF5/EGF/FGF8/ANGPT2/NTF4/RAF1/RALBP1/RASA1/EFNA1/NRAS/FGFR4/KSR1/SOS2/FGFR3/FGF3/NTF3/TEK/NF1/FLT4/ARF6/RGL2/GNB2/FGF4/CALM2/CALM3/PAK4/MAPK8/GNG5/PLA2G2D/RALB/GNG10/PDGFA/ANGPT1/CALML5/CHUK/CALML4/MAPK9/FGF23/IGF1R/PIK3CB/PLA2G1B/GNGT1/PLA2G4F/IKBKG/NTRK1/FGF16/FASLG/PLA2G2F/PLA2G2A/PAK2/RASSF5/CALML3/CALML6/PLA2G4A/INS/GRIN2B/GNG7/RAC1/PLA2G12A/FLT1/PAK1/PRKCA/CALM1/CDC42/MET/FGF9/NGF/FGF18/GNG8/RASGRP4/PDGFC/FGF19/FGF20/PRKACA/FGFR1/BAD/GRB2/GAB2/AKT3/RGL1/KIT/RASAL1/GRIN1/FLT3LG/HTR7/TGFA/PLCE1/RASA2/STK4/GRIN2A/PDGFRA/FGF1/RAP1A/PIK3CD/GNG13/HGF/FGF2/RHOA/RASGRP3/RAC3/FGF22/ANGPT4/JMJD7-PLA2G4B/PAK3/MAP2K2/KSR2/PLD1/PIK3R3/PRKCG/SHC3/GAB1/RASA4/RASA4B/EFNA3/ETS1/PLCG2/KITLG/EPHA2/PLA2G2E/BDNF/GNG3/NTRK2/FGF21/RAC2/CSF1/SHOC2/RIN1/EXOC2/RAP1B/PGF/PDGFD/PLA2G12B/RASGRF1/PLA2G3/PRKACB/FOXO4/PIK3R2/BRAP/FGF17/VEGFC/PLA1A/PLA2G10/MAPK1/PIK3CA/AKT1/PLA2G6/ZAP70/CSF1R/GNG12/NGFR/MAPK3/ABL1/FGF5/MAP2K1/REL/RASGRF2/PLA2G5/ABL2/ELK1/PAK6/SHC2/TIAM1/SOS1/NFKB1/GNB4/RALA/FLT3/PRKACG/EFNA4/VEGFB/BCL2L1	184
KEGG	hsa04540	Gap junction	73/5985	88/8135	0.02588	0.1016	0.06946	HRAS/TUBB1/EGFR/KRAS/EGF/ITPR2/ADCY6/RAF1/NRAS/SOS2/PLCB3/ADCY7/PRKG1/HTR2B/MAP2K5/GRM1/DRD2/TUBA1C/PDGFA/TUBA1A/MAP3K2/ADCY9/ADCY8/GNA11/PRKCA/GJD2/TUBA1B/SRC/PDGFC/PRKACA/GRB2/LPAR1/GUCY1A2/MAPK7/PDGFRA/TUBA3C/TUBA3D/TUBB6/PLCB4/MAP2K2/PRKCG/TUBB2A/GNAQ/GRM5/ITPR3/TUBA4A/PDGFD/ADCY5/TJP1/GNAI2/GJA1/PRKACB/PLCB2/GNAI3/TUBB4A/HTR2A/ITPR1/TUBB3/MAPK1/ADRB1/MAPK3/TUBB4B/HTR2C/MAP2K1/TUBA8/DRD1/TUBB/ADCY3/SOS1/TUBAL3/PLCB1/CDK1/PRKACG	73
KEGG	hsa05135	Yersinia infection	111/5985	137/8135	0.02602	0.1016	0.06946	PKN1/ARPC1B/PIP5K1A/NFKBIA/PTK2B/ARPC4/JUN/ITGB1/AKT2/ACTG1/TRAF6/GSK3B/ITGA4/ARHGEF7/ACTR3/ACTB/IRAK4/WIPF2/MEFV/ARPC1A/ARF6/PYCARD/ACTR2/IRF3/MYD88/MAPK8/TAB1/ROCK1/LIMK1/ITGA5/MAP3K7/ARHGEF12/MAP2K3/ARPC5L/MAP2K4/CHUK/PTK2/MAPK9/ROCK2/CRK/PIK3CB/IKBKG/ARHGEF1/RPS6KA1/PIP5K1C/RPS6KA3/TLR4/RAC1/CDC42/SRC/VAV1/LCK/RHOG/AKT3/ARPC2/SKAP2/NFATC2/WASL/IL18/PIK3CD/PIP5K1B/CASP1/RHOA/RAC3/ELMO2/MAP2K2/CCL2/IL2/CD8A/PIK3R3/IL10/PKN2/GIT2/RPS6KA6/TRAF2/GNAQ/IL1B/TICAM1/RAC2/FOS/WASF2/PXN/VAV2/FN1/ARHGEF28/PIK3R2/VAV3/TAB2/CXCL8/WAS/MAPK1/PIK3CA/AKT1/ZAP70/FCGR2A/IRAK1/MAPK3/RPS6KA2/MAPK14/BCAR1/MAP2K1/LCP2/ARPC3/NLRC4/MAP2K7/LOC102723407/MAPK13/NFKB1/WIPF3/IL6/WIPF1	111
KEGG	hsa05416	Viral myocarditis	51/5985	60/8135	0.02604	0.1016	0.06946	SGCA/EIF4G2/MYH6/MYH7/HLA-C/ACTG1/HLA-G/EIF4G3/ACTB/HLA-E/HLA-A/HLA-B/CAV1/HLA-F/BID/CD80/HLA-DPA1/CASP9/RAC1/HLA-DMB/HLA-DRB1/CD40/EIF4G1/HLA-DQA2/HLA-DRA/CD86/HLA-DMA/CD40LG/RAC3/ITGAL/HLA-DQB1/SGCD/DMD/SGCB/LAMA2/ITGB2/HLA-DOB/HLA-DRB4/DAG1/RAC2/HLA-DOA/FYN/PRF1/CD55/HLA-DPB1/ABL1/HLA-DQA1/ABL2/LOC102723407/CXADR/CD28	51
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	87/5985	106/8135	0.02613	0.1016	0.06946	JUND/ATF6B/RXRB/ARAF/ATF2/EGFR/MMP14/PDE4C/NR4A2/BRAF/MEF2D/SP1/ITPR2/ADCY6/RUNX2/RAF1/CREB5/PLCB3/ADCY7/PDE4D/MMP25/CREB3L3/CASR/PDE4A/CREB3/RXRA/SLC34A3/CREB3L4/BGLAP/GNA13/FGF23/MEF2C/PTHLH/ARHGEF1/EGR1/ADCY9/ADCY8/PDE4B/GNA11/PRKCA/MAFB/PRKACA/FGFR1/MMP24/SLC9A3R1/CYP27B1/SLC34A2/MMP13/VDR/GNA12/CREB1/TRPV5/PLCB4/BCL2/RHOA/PTH1R/PLD1/PRKCG/SLC34A1/KL/LRP6/ATF4/GNAQ/GCM1/ITPR3/FOS/ADCY5/NACA/GNAI2/PRKACB/CREB3L1/PLCB2/GNAI3/ARRB2/ITPR1/MAPK1/CDKN1A/MAPK3/MMP15/TNFSF11/MAP2K1/LRP5/ADCY3/ARRB1/PLCB1/PRKACG/SOST	87
KEGG	hsa03015	mRNA surveillance pathway	80/5985	97/8135	0.02615	0.1016	0.06946	SMG7/PPP2R1A/PABPC3/FUS/PABPN1/DDX39B/PPP2R3C/PABPC1/SAP18/MAGOH/RNMT/BCL2L2-PABPN1/NCBP1/FIP1L1/PPP1CC/PPP2R2D/ACIN1/DDX19B/PAPOLA/SRRM1/WDR33/PPP1CB/RNPS1/CASC3/EIF4A3/RBM8A/PABPC1L2A/PABPC1L2B/PPP2R5B/PNN/CPSF2/CSTF3/PCF11/PPP2R1B/PPP2CA/UPF3A/SMG5/MSI2/PABPC4L/CSTF2T/NXF1/NXF2/NXF2B/GSPT2/CLP1/MAGOHB/NCBP2/CPSF7/HBS1L/UPF1/UPF3B/SYMPK/PPP2R5C/SMG1/PPP2R3A/PELO/CPSF4/CPSF1/PABPC5/NXT1/ALYREF/PPP2R2C/MSI1/CSTF2/PPP2R5D/NUDT21/DAZAP1/GSPT1/PPP2R2A/PPP1CA/PPP2R3B/ETF1/TARDBP/CPSF6/PABPC1L/WDR82/PABPC4/PAPOLG/NXF3/PPP2R5A	80
KEGG	hsa05215	Prostate cancer	80/5985	97/8135	0.02615	0.1016	0.06946	TP53/TMPRSS2/HRAS/ARAF/MDM2/EGFR/KRAS/NFKBIA/BRAF/AKT2/GSK3B/EGF/RAF1/CREB5/CDKN1B/MMP9/NRAS/SOS2/MTOR/PDPK1/IL1R2/CREB3L3/HSP90AB1/AR/CREB3/CREBBP/CCNE2/CREB3L4/PDGFA/CHUK/IGF1R/PIK3CB/IKBKG/CASP9/CTNNB1/ERBB2/INS/TCF7L1/HSP90B1/PDGFC/FGFR1/BAD/GRB2/AKT3/TGFA/E2F3/CREB1/RB1/PDGFRA/PIK3CD/BCL2/MAP2K2/SRD5A2/EP300/INSRR/PIK3R3/CDK2/PTEN/ATF4/SPINT1/HSP90AA1/PLAT/PDGFD/FOXO1/NKX3-1/CREB3L1/PIK3R2/KLK3/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/MAP2K1/GSTP1/MMP3/ETV5/CCNE1/SOS1/NFKB1	80
KEGG	hsa05016	Huntington disease	240/5985	306/8135	0.02696	0.1034	0.07073	DCTN1/TP53/PSMD7/PSMA3/SDHC/ND3/DCTN2/POLR2A/TUBB1/COX7B/ND6/SIN3A/AMBRA1/NDUFA10/POLR2K/COX6C/UQCRB/COX7C/KLC3/PIK3R4/DNAH1/DCTN6/SDHD/CLTC/GPX1/NDUFA1/TAF4/ATG2B/ND2/DNAH17/NDUFB7/SP1/PSMB3/NDUFB6/TBP/TGM2/CLTA/HAP1/CREB5/COX3/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NDUFS5/NRBF2/GPX2/PLCB3/MAP3K5/PSMC2/KLC1/GPX3/COX1/MTOR/PSMB1/REST/UQCR10/ACTR10/CREB3L3/DNAL4/IFT57/BECN1/NDUFA4/NDUFS7/KIF5A/COX2/NDUFA3/PSMA5/AP2A2/POLR2J/NDUFA11/MAPK8/NDUFA6/CREB3/COX8A/SLC25A31/CREBBP/PPARGC1A/TFAM/DNAH9/NDUFV1/CREB3L4/TUBA1C/DNAI1/MAPK9/SLC25A4/NDUFA8/ATP6/AP2B1/NDUFA2/DNAH5/COX5B/WIPI2/COX6B2/CASP9/TUBA1A/POLR2D/PSMB5/PSMB4/UQCRQ/COX6A1/NDUFA13/CYC1/POLR2C/NDUFB1/GRIN2B/NDUFA7/POLR2F/POLR2H/DCTN3/ATG14/PIK3C3/AP2S1/COX7A1/POLR2E/PSMB2/PSMC6/GPX5/PSMD11/TUBA1B/PSMD1/STX1A/ULK1/AP2A1/BAX/UQCRFS1/NDUFB2/APAF1/NDUFB10/POLR2G/SDHB/DNAI2/NDUFS6/PSMD2/NDUFS3/ND4/GRIN1/SLC25A6/NDUFV3/ATG13/DNAH10/POLR2J3/PSMA1/CREB1/TUBA3C/TUBA3D/TUBB6/PLCB4/SLC25A5/UQCRC1/PSMB6/DNAL1/TBPL1/VDAC1/DNAH6/PSMD3/NRF1/EP300/DNAH8/NDUFA9/TUBB2A/PSMA7/DLG4/NDUFS4/SLC1A2/RCOR1/GPX7/HTT/NDUFB5/HIP1/UQCRC2/TRAF2/GNAQ/RB1CC1/BDNF/PPARG/GRM5/DNALI1/PSMC5/PSMA4/NDUFA4L2/ERN1/TUBA4A/HDAC2/KCNJ10/ADRM1/PSMD9/COX7A2L/UQCR11/NDUFB9/PSMA8/NDUFV2/NDUFB8/KIF5C/GRIA4/ATG101/CREB3L1/PLCB2/PSMC3/NDUFS1/TUBB4A/SLC1A3/NDUFS2/PSMD12/NDUFB4/GRIA2/ACTR1A/ITPR1/COX6B1/SOD2/TUBB3/DNAH14/PPIF/DCTN5/TUBB4B/HDAC1/PSMA2/PSMD4/VDAC2/ACTR1B/NDUFB3/COX5A/POLR2B/TAF4B/TUBA8/PSMB7/TUBB/KLC4/MAP2K7/DCTN4/ATG2A/PSMD8/POLR2J2/CLTCL1/TUBAL3/NDUFAB1/PLCB1/VDAC3/COX8C	240
KEGG	hsa04071	Sphingolipid signaling pathway	97/5985	119/8135	0.02725	0.1034	0.07073	TP53/PPP2R1A/HRAS/ABCC1/PPP2R3C/CERS5/KRAS/PPP2R2D/TRADD/AKT2/S1PR4/CERS2/RAF1/DEGS1/NOS3/NRAS/CERS3/PPP2R5B/PLCB3/MAP3K5/DEGS2/PDPK1/FCER1A/SPHK1/CERS1/SPHK2/SGMS1/MAPK8/PPP2R1B/ROCK1/PPP2CA/TNFRSF1A/GNA13/MAPK9/ROCK2/PIK3CB/BID/S1PR3/PRKCZ/RAC1/MS4A2/PRKCA/SMPD1/BAX/ASAH1/KNG1/ADORA3/GAB2/AKT3/SGPP2/SGMS2/GNA12/SPTLC2/FCER1G/PIK3CD/PPP2R5C/PLCB4/BCL2/PPP2R3A/RHOA/RAC3/MAP2K2/SPTLC1/PLD1/PIK3R3/PRKCG/PPP2R2C/PTEN/PPP2R5D/TRAF2/GNAQ/PPP2R2A/RAC2/FYN/PPP2R3B/ADORA1/CTSD/CERS4/SMPD2/GNAI2/PLCB2/GNAI3/PIK3R2/MAPK1/PIK3CA/AKT1/NSMAF/S1PR5/MAPK3/MAPK14/MAP2K1/PRKCE/S1PR2/MAPK13/NFKB1/PLCB1/PPP2R5A	97
KEGG	hsa04728	Dopaminergic synapse	107/5985	132/8135	0.02788	0.1046	0.07157	PPP2R1A/ATF6B/GNG2/PPP2R3C/ATF2/GNG11/GNG4/CALY/PPP1CC/PPP2R2D/AKT2/GSK3B/ITPR2/PPP1CB/PPP3CC/SLC18A2/CREB5/PPP2R5B/PLCB3/DRD2/SLC6A3/GNB2/CREB3L3/KIF5A/CALM2/CALM3/MAPK8/PPP2R1B/GNG5/CREB3/PPP2CA/KCNJ6/CREB3L4/GNG10/GSK3A/CALML5/CALML4/MAPK9/PPP1R1B/KCNJ9/GNGT1/CAMK2G/PPP3CA/CALML3/CALML6/GRIN2B/GNG7/PRKCA/CALM1/GNAL/GNG8/TH/PRKACA/AKT3/DRD5/CACNA1A/CREB1/GRIN2A/DDC/PPP2R5C/GNG13/DRD3/PLCB4/PPP2R3A/DRD4/KCNJ3/PRKCG/PPP2R2C/PPP2R5D/ATF4/GNAQ/GNG3/PPP2R2A/CACNA1C/ITPR3/LRTOMT/PPP3CB/PPP1CA/PPP2R3B/FOS/CACNA1D/ADCY5/GNAI2/COMT/CAMK2D/KIF5C/GRIA4/PRKACB/CREB3L1/PLCB2/GNAI3/ARRB2/GRIA2/ITPR1/AKT1/GNG12/MAPK14/GNAO1/DRD1/MAPK13/ARNTL/GNB4/ARRB1/PLCB1/CAMK2B/PRKACG/PPP2R5A	107
KEGG	hsa04260	Cardiac muscle contraction	72/5985	87/8135	0.0296	0.1099	0.07513	ATP2A3/MYL4/COX7B/TPM4/ATP1B3/COX6C/UQCRB/COX7C/CACNG6/MYH6/CACNG8/MYH7/CASQ2/TPM2/SLC8A3/TPM1/CACNG5/TNNC1/COX3/UQCRH/UQCRHL/COX4I1/ATP2A2/CACNA2D3/COX1/UQCR10/COX2/COX8A/TNNI3/CACNG2/CACNG1/CACNG4/COX5B/CACNG7/COX6B2/UQCRQ/COX6A1/ATP1B2/CYC1/ATP1A3/CACNB2/COX7A1/TPM3/CACNB1/UQCRFS1/ACTC1/SLC8A2/ATP1A1/CACNA1F/UQCRC1/ASPH/UQCRC2/ATP2A1/CACNA1C/CACNA2D1/CACNA1D/MYL3/COX7A2L/UQCR11/SLC9A7/ATP1A2/RYR2/SLC9A1/TNNT2/CACNG3/CACNB3/COX6B1/CACNB4/COX5A/TRDN/HRC/COX8C	72
KEGG	hsa04330	Notch signaling pathway	50/5985	59/8135	0.03052	0.112	0.07662	DVL3/PSENEN/PSEN1/MAML1/NCOR2/NCSTN/TLE4/DTX3L/RBPJ/NUMB/TLE6/CTBP2/CREBBP/APH1B/RFNG/HEY2/DLL1/KAT2A/KAT2B/PTCRA/DTX3/RBPJL/DTX4/ATXN1L/PSEN2/CIR1/NUMBL/EP300/APH1A/DTX1/NOTCH1/HES5/SNW1/HDAC2/TLE3/NOTCH2/HES1/CTBP1/DLL4/HEY1/TLE2/NOTCH4/MFNG/ATXN1/DLL3/HDAC1/HEYL/NOTCH3/MAML2/DVL1	50
KEGG	hsa03020	RNA polymerase	30/5985	34/8135	0.03309	0.12	0.08204	POLR2A/POLR2K/POLR3K/POLR3G/ZNRD1/POLR2J/POLR3F/TWISTNB/POLR3E/POLR2D/POLR2C/POLR2F/POLR2H/POLR2E/POLR3A/POLR3B/CRCP/POLR2G/CD3EAP/POLR3C/POLR1B/POLR2J3/POLR1E/POLR1D/POLR3H/POLR2M/POLR3D/POLR2B/POLR2J2/POLR1C	30
KEGG	hsa04625	C-type lectin receptor signaling pathway	85/5985	104/8135	0.0334	0.12	0.08204	HRAS/PTPN11/MDM2/MAPKAPK2/KRAS/NFKB2/NFKBIA/JUN/AKT2/ITPR2/RAF1/PPP3CC/NFATC4/NRAS/KSR1/IRF1/CLEC4E/PYCARD/CALM2/CALM3/MAPK8/ARHGEF12/SYK/CALML5/CHUK/LSP1/CALML4/MAPK9/PIK3CB/CLEC1B/IKBKG/STAT2/PPP3CA/CALML3/CALML6/RELB/PAK1/CALM1/PRKCD/SRC/CD209/AKT3/PLK3/BCL3/NFATC2/FCER1G/PIK3CD/CCL17/CASP1/RHOA/IL2/IL17D/CLEC4D/IKBKE/PIK3R3/IL10/MALT1/EGR2/STAT1/CLEC4M/PLCG2/CYLD/IL23A/ITPR3/IL1B/PPP3CB/CARD9/PTGS2/PIK3R2/ITPR1/MAPK1/CLEC7A/PIK3CA/AKT1/MAPK3/MAPK14/CCL22/EGR3/IRF9/MAPK13/CBLB/PPP3R1/NFKB1/IL6/IL12A	85
KEGG	hsa05210	Colorectal cancer	71/5985	86/8135	0.0338	0.1201	0.08213	TP53/HRAS/ARAF/EGFR/KRAS/JUN/BRAF/SMAD3/AKT2/MLH1/MSH6/GSK3B/EGF/AREG/RAF1/NRAS/RPS6KB2/SOS2/SMAD4/MTOR/BCL2L11/MAPK8/RPS6KB1/APPL1/RALB/MAPK9/PIK3CB/GADD45A/CASP9/CTNNB1/AXIN1/APC/RAC1/APC2/TCF7L1/PMAIP1/BAX/BAD/TGFBR1/GRB2/AKT3/TGFA/SMAD2/PIK3CD/BCL2/RHOA/RAC3/MAP2K2/TGFBR2/DCC/TGFB1/PIK3R3/POLK/GADD45B/DDB2/RAC2/FOS/PIK3R2/EREG/MAPK1/PIK3CA/AKT1/CDKN1A/AXIN2/MAPK3/MAP2K1/BAK1/TGFB3/BIRC5/SOS1/RALA	71
KEGG	hsa04659	Th17 cell differentiation	88/5985	108/8135	0.03515	0.1221	0.08353	IL2RG/NFKBIB/RXRB/JAK3/RUNX1/NFKBIA/JUN/SMAD3/JAK1/PPP3CC/IL6R/SMAD4/MTOR/IL12RB1/HSP90AB1/IL6ST/MAPK8/IFNGR2/STAT5B/RXRA/CHUK/MAPK9/HLA-DPA1/IKBKG/IL27RA/IFNGR1/FOXP3/IRF4/PPP3CA/CD247/HLA-DMB/IL4/LCK/HIF1A/TGFBR1/HLA-DRB1/HLA-DQA2/HLA-DRA/IL21/HLA-DMA/SMAD2/IL23R/STAT5A/NFATC2/IL1RAP/HLA-DQB1/TGFBR2/IL2/EBI3/TGFB1/IL1R1/STAT1/RORC/HLA-DOB/TBX21/HLA-DRB4/IL23A/IFNG/IL17A/IL1B/HSP90AA1/PPP3CB/AHR/HLA-DOA/IL2RB/TYK2/FOS/IL17F/PRKCQ/IL21R/IL4R/HLA-DPB1/RARA/STAT3/JAK2/RORA/MAPK1/ZAP70/IL27/IL2RA/MAPK3/MAPK14/HLA-DQA1/MAPK13/PPP3R1/NFKB1/CD3G/IL6	88
KEGG	hsa04137	Mitophagy - animal	60/5985	72/8135	0.03539	0.1221	0.08353	TP53/CITED2/RAB7A/HRAS/UBB/KRAS/AMBRA1/PGAM5/BNIP3L/JUN/TOMM7/UBA52/SP1/GABARAPL2/ATG5/PINK1/TFEB/NRAS/NBR1/CSNK2A1/CSNK2B/MAP1LC3B/BECN1/MAPK8/FIS1/UBC/GABARAPL1/CALCOCO2/RHOT1/GABARAP/MAPK9/OPTN/MAP1LC3A/MITF/MFN2/SRC/ULK1/FUNDC1/MAP1LC3C/HIF1A/MFN1/TFE3/RHOT2/USP8/USP15/ATG9B/TAX1BP1/BNIP3/ATF4/RAB7B/TBC1D17/MAP1LC3B2/SQSTM1/EIF2AK3/CSNK2A2/USP30/ATG9A/FOXO3/RPS27A/BCL2L1	60
KEGG	hsa05213	Endometrial cancer	49/5985	58/8135	0.03569	0.1221	0.08353	TP53/HRAS/ARAF/EGFR/KRAS/BRAF/AKT2/MLH1/GSK3B/EGF/RAF1/NRAS/SOS2/PDPK1/PIK3CB/GADD45A/CASP9/CTNNA3/CTNNB1/ERBB2/AXIN1/APC/APC2/TCF7L1/BAX/BAD/GRB2/AKT3/PIK3CD/MAP2K2/PIK3R3/POLK/PTEN/GADD45B/CDH1/DDB2/CTNNA1/PIK3R2/MAPK1/PIK3CA/AKT1/CDKN1A/AXIN2/MAPK3/MAP2K1/BAK1/ELK1/FOXO3/SOS1	49
KEGG	hsa04614	Renin-angiotensin system	21/5985	23/8135	0.03584	0.1221	0.08353	LNPEP/MME/CPA3/MAS1/PRCP/ATP6AP2/NLN/CTSA/REN/THOP1/KLK2/PREP/CTSG/ACE/KLK1/AGT/ENPEP/AGTR2/CMA1/AGTR1/ACE2	21
KEGG	hsa04932	Non-alcoholic fatty liver disease	124/5985	155/8135	0.03806	0.1275	0.08718	SDHC/COX7B/NDUFA10/COX6C/UQCRB/JUN/ADIPOR1/COX7C/SDHD/MLXIP/NDUFA1/AKT2/NDUFB7/GSK3B/NDUFB6/SOCS3/COX3/UQCRH/UQCRHL/COX4I1/NDUFS5/IL6R/MAP3K5/COX1/BCL2L11/CEBPA/UQCR10/NDUFA4/NDUFS7/ITCH/COX2/NDUFA3/PRKAG3/NDUFA11/MAPK8/NDUFA6/COX8A/RXRA/TNFRSF1A/XBP1/NDUFV1/GSK3A/MAPK9/IRS1/NDUFA8/PIK3CB/BID/NDUFA2/COX5B/FASLG/COX6B2/ADIPOR2/UQCRQ/COX6A1/NDUFA13/CYC1/NDUFB1/INS/NDUFA7/RAC1/MAP3K11/COX7A1/CDC42/BAX/UQCRFS1/NDUFB2/NDUFB10/SDHB/NDUFS6/AKT3/NDUFS3/NDUFV3/PIK3CD/UQCRC1/LEPR/TGFB1/PIK3R3/NDUFA9/NDUFS4/PRKAG1/NDUFB5/ATF4/UQCRC2/TRAF2/PPARG/NDUFA4L2/IL1B/ERN1/SREBF1/FOS/COX7A2L/PRKAB1/UQCR11/NDUFB9/PKLR/NDUFV2/NDUFB8/MLXIPL/EIF2S1/MLX/NDUFS1/PIK3R2/DDIT3/NDUFS2/NDUFB4/COX6B1/CXCL8/EIF2AK3/PIK3CA/AKT1/IRS2/MAPK14/PRKAA1/NDUFB3/COX5A/CYP2E1/NR1H3/IL1A/MAPK13/FAS/NFKB1/IL6/NDUFAB1/COX8C	124
KEGG	hsa05220	Chronic myeloid leukemia	63/5985	76/8135	0.0383	0.1275	0.08718	TP53/HRAS/ARAF/SHC1/PTPN11/MDM2/KRAS/RUNX1/NFKBIA/BRAF/CDK6/SMAD3/AKT2/RAF1/CDKN1B/NRAS/SOS2/SMAD4/CTBP2/STAT5B/CHUK/CRK/PIK3CB/IKBKG/GADD45A/BAX/BAD/TGFBR1/GRB2/GAB2/AKT3/CDK4/E2F3/RB1/STAT5A/PIK3CD/MAP2K2/TGFBR2/TGFB1/PIK3R3/POLK/GADD45B/SHC3/DDB2/HDAC2/MECOM/PIK3R2/CTBP1/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/HDAC1/ABL1/MAP2K1/BAK1/TGFB3/SHC2/CDKN2A/SOS1/NFKB1/BCL2L1	63
KEGG	hsa04120	Ubiquitin mediated proteolysis	114/5985	142/8135	0.03855	0.1275	0.08718	UBE4B/HERC1/ANAPC15/SMURF1/UBA1/MDM2/UBB/UBE3B/HERC3/HUWE1/SKP2/DDB1/CUL4B/UBA52/FBXW11/RHOBTB1/CDC34/UBA7/TRAF6/UBE2D1/UBE4A/UBE2D3/SOCS3/SYVN1/UBE2O/CUL1/DET1/XIAP/UBE2H/FBXW7/WWP2/BRCA1/KEAP1/CUL3/ANAPC16/ANAPC13/UBE2M/FZR1/UBE2NL/RCHY1/ITCH/NEDD4L/MGRN1/ANAPC5/SOCS1/CUL7/UBC/CDC23/UBE3C/FBXW8/UBE2D2/UBE2E3/CBLC/UBE2R2/PML/UBE2G2/CUL5/UBE2B/CUL2/FANCL/SIAH1/UBOX5/HERC2/UBE2Q1/PIAS4/UBE2N/STUB1/UBE2E2/UBE2C/TRIM37/TRIM32/ANAPC7/UBE2L3/CUL4A/ANAPC10/PIAS2/BIRC7/BTRC/PPIL2/ANAPC2/FBXO2/UBE2Z/UBE2S/KLHL13/PRPF19/UBR5/UBE2F/UBE2Q2/DDB2/WWP1/TRIP12/UBA3/UBE2K/UBE2A/RHOBTB2/MID1/AIRE/UBE2L6/UBE2QL1/CDC16/CDC20/KLHL9/SAE1/UBE2I/BIRC6/UBA2/VHL/UBE3A/CBLB/UBE2D4/UBE2U/FBXO4/RPS27A/BIRC3	114
KEGG	hsa00071	Fatty acid degradation	37/5985	43/8135	0.03973	0.1284	0.08781	CPT1A/ALDH9A1/CPT2/HADHB/ALDH1B1/ACSL1/ACAT1/ECI1/ECI2/ADH1B/ACOX1/ACADS/ACADM/CPT1B/ALDH2/HADH/CPT1C/ECHS1/ADH4/ACSL6/ACSL4/ADH5/ACSBG2/ALDH3A2/ACSL3/ADH7/GCDH/ALDH7A1/ACADVL/CYP2U1/ADH1A/ADH6/EHHADH/HADHA/ACSBG1/ACADL/ADH1C	37
KEGG	hsa04510	Focal adhesion	159/5985	201/8135	0.04027	0.1284	0.08781	HRAS/SHC1/MYL12A/PIP5K1A/EGFR/LAMB1/JUN/BRAF/MYLK4/ITGB1/COL1A1/TNN/PPP1CC/ITGB5/AKT2/MYLK3/ACTG1/VASP/GSK3B/EGF/ARHGAP35/ITGA4/PPP1CB/RAF1/PARVA/VWF/ACTB/XIAP/SOS2/PARVG/DIAPH1/CAV3/ACTN4/PDPK1/FLT4/TLN2/COMP/ITGB3/ITGA10/PAK4/MAPK8/COL6A3/ROCK1/ITGA9/CCND2/ITGA5/ACTN1/CAV1/PPP1R12C/MYLK/COL2A1/PDGFA/PTK2/COL1A2/ITGB4/COL4A1/CAV2/MAPK9/ITGA11/ROCK2/CRK/IGF1R/PIK3CB/COL6A1/RELN/VTN/PAK2/CTNNB1/ERBB2/LAMC1/CAPN2/PIP5K1C/RAC1/ITGA2B/COL4A2/FLT1/PAK1/PRKCA/CDC42/MET/SRC/VAV1/PDGFC/ITGB6/CHAD/BAD/GRB2/AKT3/THBS4/PDGFRA/THBS2/RAP1A/LAMB2/PIK3CD/TNR/PIP5K1B/HGF/BCL2/RHOA/RAC3/PAK3/LAMB3/PIK3R3/PRKCG/MYL7/FLNB/RAPGEF1/LAMA2/PTEN/SHC3/MYL9/COL6A2/IBSP/RAC2/PPP1CA/FYN/RAP1B/PGF/PDGFD/RASGRF1/ZYX/PXN/MYLK2/VAV2/MYLPF/FN1/PPP1R12B/FLNC/LAMA5/ITGA1/PIK3R2/COL9A2/MYL5/VAV3/VEGFC/MYL12B/MAPK1/PIK3CA/AKT1/MAPK3/ITGA2/THBS3/SPP1/BCAR1/MAP2K1/THBS1/ELK1/LAMC2/LAMC3/PAK6/SHC2/SOS1/ITGA3/ITGA8/ITGA6/VCL/ARHGAP5/VEGFB/BIRC3	159
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	80/5985	98/8135	0.04036	0.1284	0.08781	PPP1CC/ITPR2/ADCY6/TRPV2/PPP1CB/PTGER4/PLCB3/ADCY7/HTR2B/F2RL1/ALOX12/ASIC3/CALM2/CALM3/MAPK8/MAP2K3/CALML5/CALML4/MAPK9/PIK3CB/HRH1/PLA2G4F/NTRK1/CAMK2G/CYP2J2/PTGER2/CALML3/CALML6/PLA2G4A/ADCY9/ADCY8/PRKCA/CALM1/PRKCD/SRC/NGF/PRKACA/KNG1/TRPV4/TRPA1/ASIC1/PIK3CD/ASIC5/PLCB4/IL1RAP/JMJD7-PLA2G4B/PIK3R3/TRPV1/PRKCG/IL1R1/GNAQ/PLCG2/ITPR3/IL1B/PPP1CA/ADCY5/PRKCQ/CAMK2D/PRKACB/PLCB2/PIK3R2/P2RY2/HTR2A/ITPR1/PIK3CA/PLA2G6/MAPK14/HTR2C/TRPM8/PRKCE/ASIC2/MAPK13/ADCY3/PRKCH/ASIC4/PLCB1/CAMK2B/TRPV3/BDKRB1/PRKACG	80
KEGG	hsa04925	Aldosterone synthesis and secretion	80/5985	98/8135	0.04036	0.1284	0.08781	ATF6B/ATF2/ATP1B3/NR4A2/ATF1/ITPR2/ADCY6/CREB5/CACNA1H/CYP11B2/PLCB3/ADCY7/KCNK3/CREB3L3/STAR/CALM2/CALM3/CREB3/KCNK9/CREB3L4/CALML5/CALML4/SCARB1/CAMK2G/CAMK1D/ATP1B2/CALML3/CALML6/ADCY9/ORAI1/ATP1A3/CAMK1G/ADCY8/GNA11/PRKCA/CALM1/PRKACA/LDLR/MC2R/NPR1/ATP1A1/POMC/CACNA1G/CACNA1F/CREB1/PLCB4/PRKD2/ATP2B3/CYP11A1/PRKCG/ATF4/GNAQ/AGT/ATP2B4/CACNA1C/ATP2B2/ITPR3/HSD3B1/PRKD1/CACNA1D/AGTR1/ADCY5/DAGLA/ATP2B1/LIPE/CAMK2D/ATP1A2/PRKACB/CREB3L1/PLCB2/ITPR1/CACNA1I/PRKCE/PRKD3/NR4A1/ADCY3/PLCB1/CAMK2B/PRKACG/PDE2A	80
KEGG	hsa04141	Protein processing in endoplasmic reticulum	136/5985	171/8135	0.04202	0.1324	0.09055	UBE4B/ATF6B/PRKCSH/UBXN6/SAR1A/UBXN2A/CRYAB/UBQLN1/OS9/BAG1/UBQLN3/EDEM1/MAN1A2/SAR1B/UBE2D1/BCAP31/UBE2D3/SEL1L/DDOST/SYVN1/DNAJC5G/DAD1/CUL1/UBXN4/AMFR/VCP/RNF5/MAP3K5/SEC61A2/UGGT1/RPN1/HSPA1L/ATF6/NGLY1/UBQLN4/SSR2/TRAM1/HSP90AB1/CALR/FBXO6/HSPA1A/HSPA1B/CANX/NFE2L2/MAPK8/SEC24D/TXNDC5/LMAN1/SEC13/HSPA6/DNAJB11/UBE2D2/RNF185/PPP1R15A/XBP1/SEC61G/UBXN1/DNAJC5/UBE2G2/DNAJA2/MAPK9/PLAA/MAN1C1/DNAJC5B/TRAM1L1/HSPBP1/SIL1/SEC62/NPLOC4/CAPN2/PREB/STT3B/NSFL1C/STUB1/RRBP1/HSP90B1/UBQLN2/BAX/CKAP4/EIF2AK1/DNAJB1/PDIA4/CAPN1/SEC61A1/TUSC3/SEC31A/SSR1/ERP29/MBTPS1/BCL2/DNAJB2/SSR4/DERL2/WFS1/ATXN3/FBXO2/PDIA6/SEL1L2/ATF4/EIF2AK4/TRAF2/STT3A/P4HB/GANAB/ERN1/HSP90AA1/ERLEC1/CASP12/YOD1/LMAN2/SEC24A/EIF2S1/EIF2AK2/SEC61B/ATXN3L/DNAJB12/DDIT3/EIF2AK3/UBXN8/SEC23B/DNAJC10/EDEM2/RAD23A/MAN1A1/DERL3/SEC24B/RPN2/HSPA8/DNAJC1/BAK1/MAP2K7/UBE2D4/PDIA3/HSPA5/HSPA2/SEC23A	136
KEGG	hsa04080	Neuroactive ligand-receptor interaction	274/5985	353/8135	0.04264	0.1331	0.09102	OPRK1/HRH3/GABRG2/MC4R/SCT/NPY5R/NPFFR1/CHRM2/AVPR1B/CHRNE/UCN3/S1PR4/NR3C1/ADCYAP1/SSTR2/NMUR1/GALR3/SSTR5/MAS1/ADRA1B/GH2/TAC3/NPW/TAC4/P2RY11/FPR1/TSPO/PTGER4/TAAR9/FPR2/PTAFR/CGA/GABRA4/HTR1D/F2RL2/THRA/P2RX5/HTR2B/F2RL1/GRPR/PPY/NMUR2/GALR2/GRM1/CHRND/DRD2/GRM6/GRIN3A/ADRA2C/GRIK4/PRL/GPHA2/TRH/PTGIR/GRIK1/UCN2/EDN2/P2RX6/ADM/ADCYAP1R1/SLURP1/ADRA2B/P2RY13/GABBR1/GRID1/HTR1B/APLNR/MLNR/CORT/GABRB3/OXTR/AVPR1A/P2RY4/GIP/GHRHR/AVP/SSTR4/P2RY14/HRH1/PTH2R/NTS/GH1/S1PR3/LTB4R2/GLRA3/GRIK2/PARD3/HCRTR1/CHRNB4/OPRL1/PTGER2/CALCB/BRS3/NTSR2/ADRA2A/GRIN2B/TAAR2/LTB4R/P2RX3/GRIK3/ADRA1D/GABBR2/KISS1/CHRNA4/PTH2/LYPD6B/CHRNA9/RLN3/CNR2/C5AR1/PTGER1/CHRNB3/VIP/MC2R/PATE1/ADORA2B/NMB/AVPR2/KNG1/GIPR/GLRA2/CYSLTR1/GABRE/ADORA3/GALP/DRD5/CHRNB2/POMC/PMCH/PRLH/GRIN1/LPAR1/APLN/HTR7/EDNRB/TAAR1/HRH4/CHRNA2/GRM3/FSHR/CSH2/GABRB2/GRIN2A/HRH2/F2R/SCTR/CTSG/CHRNA10/CHRM5/TAAR5/DRD3/CHRM1/P2RX7/MC1R/F2/UTS2B/GPR35/LEPR/ADORA2A/DRD4/GABRP/GPR50/P2RX4/LPAR2/KISS1R/PTH1R/GRM2/NPY2R/GABRQ/TRPV1/GALR1/GPHB5/CHRNA1/GHRH/CALCR/GLRB/PLG/EDN3/HTR4/UCN/GABRR1/GPR156/PENK/OPRM1/NPBWR1/P2RY6/CRHR2/GHSR/HCRT/GRM5/AGT/MC5R/CHRNA3/EDNRA/RLN2/NTSR1/CHRM4/INSL3/PRSS2/IAPP/GCG/AGTR2/ADORA1/GABRR2/AGTR1/TSHB/GCGR/FPR3/CCKAR/MTNR1A/LYNX1/GPR83/CHRM3/GRM8/PTGFR/P2RX1/P2RY8/GRIA4/GRP/ADRB2/NPBWR2/RXFP1/NMU/C3AR1/GRIN2C/GNRHR/CYSLTR2/PATE2/P2RY2/HTR2A/GABRD/GNRH1/MLN/GRIA2/TACR1/GABRA3/PRSS1/CNR1/P2RY1/GRIN2D/FSHB/C5/ADRB1/S1PR5/GRM7/THRB/GZMA/TSHR/APELA/LPAR6/HTR2C/CCK/CALCRL/GRM4/GLP1R/DRD1/GRID2/GLRA1/TACR3/VIPR2/S1PR2/LHB/SST/TAC1/OXT/MC3R/HTR1F/TBXA2R/CHRNG/NPFF/HCRTR2/BDKRB1/TRHR/LPAR4	274
KEGG	hsa05226	Gastric cancer	119/5985	149/8135	0.04511	0.1385	0.09469	TP53/RXRB/HRAS/ARAF/SHC1/DVL3/FZD2/EGFR/KRAS/BRAF/SMAD3/AKT2/MLH1/WNT2/GSK3B/EGF/FRAT2/FGF8/RAF1/CDKN1B/FRAT1/NRAS/RPS6KB2/SOS2/SMAD4/FGF3/MTOR/WNT8A/FGF4/CDH17/RPS6KB1/RXRA/CCNE2/WNT1/FGF23/PIK3CB/SHH/FGF16/GADD45A/WNT2B/CTNNA3/CTNNB1/ERBB2/AXIN1/APC/APC2/WNT9B/TCF7L1/MET/FGF9/FGF18/FGF19/FGF20/BAX/TGFBR1/GRB2/AKT3/FZD3/FZD7/SMAD2/E2F3/WNT3/RB1/FGF1/PIK3CD/FZD10/JUP/HGF/FZD6/FGF2/BCL2/MUC2/FGF22/MAP2K2/TGFBR2/WNT5A/TGFB1/PIK3R3/POLK/CDK2/FZD4/GADD45B/SHC3/FZD8/GAB1/CDH1/CSNK1A1/LRP6/WNT11/DDB2/TERT/FGF21/WNT9A/CDKN2B/WNT7B/CTNNA1/WNT8B/PIK3R2/FGF17/MAPK1/PIK3CA/AKT1/CDKN1A/AXIN2/MAPK3/WNT7A/FGF5/MAP2K1/WNT5B/BAK1/CDX2/TGFB3/LRP5/CCNE1/SHC2/WNT4/DVL1/SOS1/WNT10A	119
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	79/5985	97/8135	0.04549	0.1385	0.09469	CFL1/ARPC1B/PIP5K1A/ARPC4/AKT2/VASP/ASAP2/RAF1/INPPL1/ACTR3/RPS6KB2/DNM2/ARPC1A/ARF6/NCF1/SPHK1/ACTR2/SPHK2/FCGR3B/WASF3/RPS6KB1/LIMK1/CFL2/HCK/SYK/ARPC5L/FCGR2B/CRK/PIK3CB/PLA2G4F/ASAP3/LYN/PLA2G4A/PIP5K1C/RAC1/PAK1/PRKCA/CDC42/PRKCD/VAV1/FCGR3A/GAB2/AKT3/ARPC2/MARCKSL1/AMPH/PIK3CD/PIP5K1B/JMJD7-PLA2G4B/PLD1/PIK3R3/PRKCG/WASF1/MARCKS/SCIN/GSN/PLCG2/LIMK2/RAC2/BIN1/WASF2/VAV2/FCGR1A/PIK3R2/PTPRC/VAV3/ASAP1/WAS/MAPK1/PIK3CA/AKT1/PLA2G6/FCGR2A/MAPK3/MAP2K1/PRKCE/ARPC3/INPP5D/LOC102723407	79
KEGG	hsa05012	Parkinson disease	208/5985	266/8135	0.0456	0.1385	0.09469	TP53/PSMD7/PSMA3/SDHC/UBA1/ND3/SLC39A9/DUSP1/TUBB1/UBB/SNCA/COX7B/ND6/NDUFA10/COX6C/UQCRB/COX7C/KLC3/SDHD/NDUFA1/UBA52/ND2/NDUFB7/UBA7/PSMB3/NDUFB6/ITPR2/SLC18A2/PINK1/COX3/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NDUFS5/TXN/MAP3K5/PSMC2/KLC1/COX1/SLC39A8/KEAP1/PSMB1/ATF6/DRD2/SLC6A3/UQCR10/SLC39A6/NDUFA4/NDUFS7/KIF5A/COX2/NDUFA3/CALM2/CALM3/PSMA5/NFE2L2/NDUFA11/MAPK8/NDUFA6/DAXX/COX8A/LRRK2/UBC/SLC25A31/XBP1/NDUFV1/TUBA1C/CALML5/TXN2/UBE2G2/CALML4/UCHL1/MAPK9/SLC25A4/NDUFA8/ATP6/NDUFA2/COX5B/COX6B2/CAMK2G/CASP9/TUBA1A/PSMB5/PSMB4/UQCRQ/COX6A1/NDUFA13/CALML3/CYC1/CALML6/NDUFB1/NDUFA7/HTRA2/COX7A1/PSMB2/PSMC6/PSMD11/CALM1/MFN2/RYR3/TUBA1B/SLC39A2/PSMD1/GNAL/TH/BAX/PRKACA/UQCRFS1/NDUFB2/APAF1/NDUFB10/SNCAIP/SDHB/NDUFS6/PSMD2/NDUFS3/ND4/MFN1/SLC25A6/NDUFV3/UBE2L3/PARK7/PSMA1/SLC39A13/TUBA3C/TUBA3D/TUBB6/SLC11A2/SLC25A5/UQCRC1/ADORA2A/PSMB6/VDAC1/PSMD3/NDUFA9/TUBB2A/SLC39A5/PSMA7/NDUFS4/SLC39A10/NDUFB5/ATF4/UQCRC2/SLC39A14/PSMC5/PSMA4/NDUFA4L2/ITPR3/ERN1/TUBA4A/SLC39A1/ADRM1/PSMD9/COX7A2L/UQCR11/NDUFB9/PSMA8/ADCY5/SLC39A11/NDUFV2/NDUFB8/GNAI2/UBE2L6/CAMK2D/KIF5C/EIF2S1/PRKACB/PSMC3/SLC39A7/NDUFS1/GNAI3/MAPT/TUBB4A/DDIT3/NDUFS2/PSMD12/NDUFB4/ITPR1/COX6B1/SLC39A4/TUBB3/EIF2AK3/PPIF/TUBB4B/PSMA2/PSMD4/VDAC2/NDUFB3/COX5A/TUBA8/DRD1/PSMB7/TUBB/KLC4/SLC39A3/PSMD8/RPS27A/HSPA5/TUBAL3/NDUFAB1/MCU/CAMK2B/VDAC3/COX8C/PRKACG/BCL2L1	208
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	24/5985	27/8135	0.04798	0.142	0.09712	ABO/B4GALT1/B3GALT2/B3GNT4/B4GALT4/FUT7/FUT2/B3GNT3/FUT6/A4GALT/FUT3/B4GALT3/FUT5/FUT4/B3GALT5/ST3GAL6/B3GNT5/GCNT2/B4GALT2/ST3GAL3/ST3GAL4/FUT9/B3GNT2/ST8SIA1	24
KEGG	hsa04966	Collecting duct acid secretion	24/5985	27/8135	0.04798	0.142	0.09712	SLC4A1/CA2/ATP6V1B2/ATP6V0C/ATP6V0E1/ATP6V0D2/ATP6V1C2/ATP6V1G3/CLCNKB/ATP6V0D1/ATP6V1E1/ATP6V1E2/ATP6V1A/ATP6V1F/ATP6V1C1/ATP6V1B1/ATP4B/SLC12A7/ATP6V0E2/ATP6V0A1/ATP6V1G2/ATP6V1D/ATP6V1G1/TCIRG1	24
KEGG	hsa04724	Glutamatergic synapse	92/5985	114/8135	0.04804	0.142	0.09712	GLS/GNG2/GNG11/GNG4/ITPR2/ADCY6/PPP3CC/PLCB3/ADCY7/GRM1/GRM6/GRIN3A/GNB2/GRIK4/GLS2/GRIK1/GNG5/SLC1A6/GNG10/GNGT1/PLA2G4F/SLC17A7/GRIK2/PPP3CA/PLA2G4A/GRIN2B/GNG7/ADCY9/ADCY8/PRKCA/GRIK3/GNG8/PRKACA/SLC38A3/GRIN1/SLC38A2/SHANK1/CACNA1A/GRM3/GRIN2A/GLUL/GNG13/PLCB4/HOMER2/JMJD7-PLA2G4B/KCNJ3/GRM2/PLD1/PRKCG/DLG4/SLC17A8/HOMER3/SLC1A2/GNAQ/SLC1A1/SLC1A7/GRM5/GNG3/CACNA1C/ITPR3/PPP3CB/CACNA1D/ADCY5/GRM8/TRPC1/GNAI2/GRIA4/PRKACB/SHANK3/PLCB2/GNAI3/SLC17A6/GRIN2C/SHANK2/SLC1A3/GRIA2/ITPR1/MAPK1/GNG12/DLGAP1/GRIN2D/HOMER1/MAPK3/GRM7/GNAO1/GRM4/SLC38A1/ADCY3/PPP3R1/GNB4/PLCB1/PRKACG	92
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	105/5985	131/8135	0.04932	0.1426	0.0975	HRAS/ARAF/SHC1/PTPN11/IFNA10/KRAS/IFNA16/PTK2B/IFNA14/BRAF/IFNA17/HLA-C/HLA-G/RAF1/PPP3CC/NRAS/MICB/SOS2/TNFSF10/CSF2/HLA-E/ICAM2/IFNA13/HLA-A/FCGR3B/TNFRSF10B/IFNGR2/ULBP3/HLA-B/IFNA4/SYK/CD48/MICA/PIK3CB/BID/IFNA7/IFNGR1/FASLG/PPP3CA/HCST/IFNAR1/TYROBP/RAC1/CD247/PAK1/PRKCA/GZMB/VAV1/LCK/RAET1E/FCGR3A/GRB2/SH2D1B/NFATC2/IFNA1/FCER1G/PIK3CD/RAC3/NCR3/ITGAL/MAP2K2/PIK3R3/PRKCG/KLRD1/IFNA5/SHC3/KLRC1/KLRC2/ITGB2/NCR2/PLCG2/IFNG/NCR1/SH2D1A/RAC2/PPP3CB/FYN/IFNA8/PRF1/IFNA6/KIR2DS1/VAV2/IFNA21/PIK3R2/VAV3/IFNA2/MAPK1/PIK3CA/ZAP70/IFNAR2/MAPK3/MAP2K1/LCP2/KIR2DL5A/KLRC4-KLRK1/KLRK1/TNFRSF10A/LOC102723407/SHC2/KIR2DS3/PPP3R1/FAS/SOS1/PTPN6/ULBP2	105
KEGG	hsa00430	Taurine and hypotaurine metabolism	15/5985	16/8135	0.04955	0.1426	0.0975	BAAT/FMO2/FMO4/CSAD/ADO/GGT5/FMO1/FMO5/GADL1/FMO3/CDO1/GGT6/GGT7/GGT1/GAD2	15
KEGG	hsa05321	Inflammatory bowel disease	54/5985	65/8135	0.04978	0.1426	0.0975	IL2RG/JUN/SMAD3/IL12RB1/NOD2/TLR2/IFNGR2/IL5/HLA-DPA1/IFNGR1/FOXP3/TLR4/TLR5/HLA-DMB/IL18RAP/IL4/HLA-DRB1/HLA-DQA2/HLA-DRA/IL21/HLA-DMA/SMAD2/IL23R/IL18/HLA-DQB1/IL2/TGFB1/IL10/STAT1/RORC/HLA-DOB/TBX21/HLA-DRB4/IL23A/IFNG/IL17A/IL1B/HLA-DOA/IL18R1/IL17F/IL21R/IL4R/HLA-DPB1/STAT3/RORA/STAT4/HLA-DQA1/IL1A/IL12RB2/MAF/TGFB3/NFKB1/IL6/IL12A	54
KEGG	hsa05020	Prion disease	213/5985	273/8135	0.04994	0.1426	0.0975	ATF6B/PSMD7/PSMA3/SDHC/STIP1/ND3/ATF2/TUBB1/COX7B/ND6/NDUFA10/COX6C/UQCRB/COX7C/C7/KLC3/SDHD/C8G/NDUFA1/ND2/NDUFB7/PSMB3/GSK3B/CYBA/NDUFB6/ITPR2/PPP3CC/CREB5/COX3/PSMD6/UQCRH/UQCRHL/PSMC4/COX4I1/NDUFS5/CSNK2A1/CAV3/PSMC2/KLC1/COX1/HSPA1L/PSMB1/CSNK2B/GRIN3A/NCF1/UQCR10/CREB3L3/NDUFA4/HSPA1A/HSPA1B/NDUFS7/KIF5A/COX2/NDUFA3/PSMA5/NDUFA11/MAPK8/NDUFA6/CREB3/HSPA6/COX8A/SLC25A31/NCF4/CAV1/C6/NDUFV1/CREB3L4/TUBA1C/NCF2/CAV2/MAPK9/SLC25A4/NDUFA8/PIK3CB/ATP6/NDUFA2/COX5B/COX6B2/CASP9/TUBA1A/PSMB5/PPP3CA/PSMB4/UQCRQ/COX6A1/NDUFA13/CYC1/EGR1/LAMC1/NDUFB1/GRIN2B/NDUFA7/RAC1/COX7A1/PSMB2/PSMC6/PSMD11/RYR3/TUBA1B/PSMD1/PRKCD/BAX/PRKACA/UQCRFS1/NDUFB2/APAF1/NDUFB10/SDHB/BAD/NDUFS6/PSMD2/NDUFS3/ND4/GRIN1/SLC25A6/NDUFV3/CACNA1F/PSMA1/CREB1/GRIN2A/CCL5/PIK3CD/TUBA3C/TUBA3D/TUBB6/SLC25A5/UQCRC1/PSMB6/VDAC1/PSMD3/PIK3R3/NDUFA9/TUBB2A/PSMA7/NOTCH1/NDUFS4/C8B/NDUFB5/ATF4/UQCRC2/PSMC5/CACNA1C/PSMA4/NDUFA4L2/ITPR3/IL1B/TUBA4A/RAC2/PPP3CB/FYN/ADRM1/PSMD9/CACNA1D/COX7A2L/UQCR11/CASP12/NDUFB9/PSMA8/NDUFV2/NDUFB8/C8A/KIF5C/C1QC/EIF2S1/PRKACB/CREB3L1/PSMC3/RYR2/NDUFS1/PIK3R2/GRIN2C/TUBB4A/DDIT3/NDUFS2/PSMD12/NDUFB4/ITPR1/COX6B1/TUBB3/EIF2AK3/MAPK1/PIK3CA/PPIF/GRIN2D/C5/MAPK3/TUBB4B/PSMA2/PSMD4/MAPK14/VDAC2/NDUFB3/COX5A/CSNK2A2/TUBA8/HSPA8/IL1A/PSMB7/TUBB/KLC4/MAPK13/PSMD8/PRNP/PPP3R1/HSPA5/HSPA2/TUBAL3/IL6/NDUFAB1/MCU/VDAC3/COX8C/PRKACG	213
KEGG	hsa04371	Apelin signaling pathway	111/5985	139/8135	0.05212	0.1463	0.1	GNG2/PIK3R5/HRAS/MYL4/KRAS/GNG11/GNG4/PIK3R4/MYLK4/SMAD3/MEF2D/AKT2/MYLK3/SLC8A3/ITPR2/ADCY6/RAF1/NOS3/NRAS/RPS6KB2/SMAD4/PLCB3/ADCY7/MTOR/SPHK1/GNB2/MAP1LC3B/BECN1/SPHK2/CALM2/CALM3/PRKAG3/RPS6KB1/GNG5/PPARGC1A/HDAC5/TFAM/APLNR/GNA13/GNG10/MYLK/CALML5/CALML4/GNGT1/NOS1/MEF2C/ACTA2/PLIN1/MAP1LC3A/KLF2/CALML3/EGR1/CALML6/GNG7/ADCY9/PIK3C3/ADCY8/CALM1/RYR3/GNG8/PRKACA/HDAC4/SLC8A2/MAP1LC3C/TGFBR1/AKT3/APLN/SMAD2/GNG13/PLCB4/NOS2/MAP2K2/NRF1/CDH1/PRKAG1/GNAQ/MAP1LC3B2/GNG3/ITPR3/PLAT/MYL3/PRKAB1/AGTR1/ADCY5/MYLK2/LIPE/GNAI2/PRKACB/PLCB2/RYR2/SLC9A1/GNAI3/ITPR1/PIK3CG/PIK3R6/MAPK1/AKT1/SERPINE1/GNG12/MAPK3/SPP1/APELA/PRKAA1/MAP2K1/PRKCE/NOTCH3/PDE3B/ADCY3/GNB4/PLCB1/PRKACG	111
KEGG	hsa05418	Fluid shear stress and atherosclerosis	111/5985	139/8135	0.05212	0.1463	0.1	TP53/DUSP1/ACVR2A/JUN/MMP2/AKT2/SUMO4/SUMO3/GSTA3/ACTG1/CYBA/GSTM5/MGST1/ACVR1/ARHGEF2/NOS3/ACTB/MMP9/TXN/MAP3K5/CAV3/NPPC/MAP2K5/KEAP1/IL1R2/GPC1/ASS1/NCF1/HSP90AB1/ITGB3/CALM2/CALM3/NFE2L2/MAPK8/MAP3K7/NOX1/CAV1/TNFRSF1A/GSTA4/PDGFA/CALML5/MAP2K4/CHUK/TXN2/NCF2/PTK2/CALML4/CAV2/MAPK9/PIK3CB/IKBKG/SDC4/THBD/MEF2C/CTNNB1/KLF2/CALML3/CALML6/PRKCZ/RAC1/ITGA2B/PIAS4/GSTO1/CALM1/GSTM3/HSP90B1/SELE/SRC/MGST2/TRPV4/AKT3/MAPK7/CDH5/PIK3CD/BCL2/RHOA/RAC3/NQO1/GSTM2/CCL2/PIK3R3/IL1R1/IFNG/BMP4/IL1B/HSP90AA1/RAC2/MIR10A/FOS/PLAT/GSTA1/SQSTM1/GSTM1/SDC2/PECAM1/PIK3R2/BMPR1B/HMOX1/CTSL/GSTM4/PIK3CA/AKT1/MAPK14/PRKAA1/ACVR2B/GSTP1/IL1A/MAP2K7/MAPK13/GSTT2/NFKB1	111
KEGG	hsa04721	Synaptic vesicle cycle	64/5985	78/8135	0.05326	0.1466	0.1002	VAMP2/CLTC/STX3/UNC13B/ATP6V1B2/CLTA/ATP6V0C/SLC18A2/ATP6V0E1/ATP6V0D2/STX1B/NSF/DNM2/ATP6V0B/SLC6A3/ATP6V1C2/AP2A2/ATP6V1G3/SLC1A6/ATP6V1H/AP2B1/SLC17A7/ATP6V0D1/ATP6V1E1/ATP6V1E2/RIMS1/ATP6V1A/ATP6V1F/AP2S1/SLC6A12/ATP6V1C1/SYT1/STX1A/AP2A1/CPLX3/SLC6A4/SLC18A3/ATP6V1B1/CACNA1A/SLC32A1/RAB3A/STXBP1/SLC17A8/SLC1A2/CPLX1/SLC1A1/SLC1A7/SNAP25/SLC6A2/STX2/DNM3/SLC17A6/ATP6V0E2/SLC1A3/UNC13A/ATP6V0A1/CPLX2/ATP6V1G2/SLC6A11/ATP6V1D/ATP6V1G1/CLTCL1/SLC6A5/TCIRG1	64
KEGG	hsa04924	Renin secretion	57/5985	69/8135	0.05353	0.1466	0.1002	ADCYAP1/ITPR2/ADCY6/PPP3CC/KCNJ2/PTGER4/AQP1/PLCB3/CALM2/CALM3/REN/EDN2/ADCYAP1R1/CTSB/CALML5/CALML4/PPP3CA/PTGER2/CALML3/CALML6/CLCA1/ORAI1/CALM1/PRKACA/NPR1/CACNA1F/GUCY1A2/CREB1/PLCB4/ACE/CLCA4/EDN3/GNAQ/AGT/CACNA1C/ITPR3/EDNRA/PPP3CB/CLCA2/PDE3A/ADORA1/CACNA1D/AGTR1/ADCY5/PDE1C/GNAI2/ADRB2/PRKACB/PLCB2/GNAI3/ITPR1/ADRB1/PDE1B/PDE3B/PPP3R1/PLCB1/PRKACG	57
KEGG	hsa05211	Renal cell carcinoma	57/5985	69/8135	0.05353	0.1466	0.1002	HRAS/ARAF/PTPN11/KRAS/JUN/BRAF/ARNT/AKT2/PRCC/RAF1/NRAS/SOS2/FH/PAK4/CREBBP/CRK/PIK3CB/CUL2/EGLN3/PAK2/RAC1/PAK1/CDC42/MET/HIF1A/BAD/GRB2/AKT3/TGFA/TFE3/RAP1A/PIK3CD/HGF/EPAS1/PAK3/MAP2K2/TGFB1/EP300/PIK3R3/RAPGEF1/GAB1/ETS1/FLCN/EGLN2/RAP1B/SLC2A1/PIK3R2/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/MAP2K1/VHL/TGFB3/PAK6/SOS1	57
KEGG	hsa05225	Hepatocellular carcinoma	133/5985	168/8135	0.05522	0.15	0.1026	ARID1A/TP53/HRAS/ARAF/SHC1/DVL3/FZD2/EGFR/KRAS/BRAF/CDK6/SMARCB1/SMAD3/ACTL6A/SMARCA2/AKT2/WNT2/GSTA3/ACTG1/ARID1B/GSK3B/FRAT2/GSTM5/RAF1/MGST1/FRAT1/TXNRD1/ACTB/SMARCD1/NRAS/RPS6KB2/SOS2/SMAD4/MTOR/KEAP1/WNT8A/NFE2L2/RPS6KB1/WNT1/GSTA4/TXNRD3/IGF1R/PIK3CB/ACTL6B/GADD45A/WNT2B/CTNNB1/AXIN1/APC/APC2/WNT9B/TCF7L1/PRKCA/GSTO1/GSTM3/MET/BAX/MGST2/BAD/TGFBR1/GRB2/AKT3/BRD7/FZD3/TGFA/FZD7/CDK4/SMAD2/E2F3/WNT3/RB1/DPF1/PIK3CD/FZD10/HGF/FZD6/NQO1/GSTM2/MAP2K2/TGFBR2/WNT5A/TGFB1/PIK3R3/PRKCG/POLK/TXNRD2/FZD4/PTEN/GADD45B/SHC3/FZD8/GAB1/DPF3/CSNK1A1/LRP6/PLCG2/WNT11/DDB2/TERT/GSTA1/SMARCD2/WNT9A/GSTM1/WNT7B/WNT8B/PIK3R2/SMARCC1/PHF10/HMOX1/GSTM4/SMARCA4/MAPK1/PIK3CA/AKT1/CDKN1A/AXIN2/MAPK3/WNT7A/MAP2K1/WNT5B/GSTP1/BAK1/ELK1/TGFB3/LRP5/SHC2/WNT4/DVL1/GSTT2/CDKN2A/SOS1/WNT10A/BCL2L1	133
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	174/5985	222/8135	0.05606	0.151	0.1033	TP53/IL2RG/ANAPC15/ATF6B/JAK3/HRAS/ZFP36/ATF2/KRAS/NFKB2/RANBP1/DLG1/NFKBIA/ELK4/JUN/B2M/SMAD3/JAK1/AKT2/HLA-C/HLA-G/TBP/ADCY6/PPP3CC/TRRAP/TSPO/CREB5/NFATC4/NRAS/XIAP/SMAD4/SRF/ADCY7/CSF2/HLA-E/CCNA2/ANAPC16/IL1R2/TLN2/ANAPC13/NFYB/CREB3L3/CALR/ESPL1/HLA-A/XPO1/CANX/MAPK8/ANAPC5/CCND2/CREB3/STAT5B/HLA-B/CDC23/SLC25A31/CREBBP/CCNE2/TNFRSF1A/CREB3L4/HLA-F/MAP2K4/CHUK/PTTG2/MAPK9/SLC25A4/PIK3CB/HLA-DPA1/IKBKG/PPP3CA/MSX1/TCF3/EGR1/MAP3K3/KAT2A/ADCY9/RELB/KAT5/CRTC3/KAT2B/ADCY8/VAC14/CCNA1/HLA-DMB/BAX/PRKACA/LCK/TGFBR1/HLA-DRB1/CD40/AKT3/MMP7/HLA-DQA2/SLC25A6/HLA-DRA/ANAPC7/ATM/CDK4/HLA-DMA/FDPS/ANAPC10/SMAD2/E2F3/CREB1/RB1/STAT5A/NFATC2/PIK3CD/CHEK1/SLC25A5/ITGAL/TBPL1/VDAC1/HLA-DQB1/MAP2K2/TGFBR2/IL2/TGFB1/EP300/PIK3R3/CCNB2/ANAPC2/CDK2/IL1R1/PTEN/EGR2/MAD1L1/ITGB2/HLA-DOB/ATF4/NRP1/ETS1/HLA-DRB4/TERT/FOSL1/PPP3CB/HLA-DOA/IL2RB/FOS/ADCY5/CDKN2B/CDKN2C/LTA/SLC2A1/PRKACB/CREB3L1/HLA-DPB1/CDC16/BUB3/CDC20/PIK3R2/MAPK1/IL15/PIK3CA/AKT1/RANBP3/CDKN1A/IL2RA/MAPK3/IL15RA/VDAC2/MAP2K1/HLA-DQA1/ELK1/TGFB3/CCNE1/ADCY3/PPP3R1/CDKN2A/NFKB1/CD3G/IL6/VDAC3/PRKACG/BCL2L1	174
KEGG	hsa04931	Insulin resistance	87/5985	108/8135	0.05762	0.1533	0.1049	PTPN11/PTPN1/CPT1A/NFKBIA/MLXIP/PPP1CC/AKT2/GSK3B/PPP1CB/SOCS3/CREB5/NOS3/RPS6KB2/MTOR/OGT/PDPK1/CREB3L3/CD36/PRKAG3/PYGL/MAPK8/RPS6KB1/CREB3/SLC27A1/PPARGC1A/TNFRSF1A/CREB3L4/CPT1B/PPP1R3D/MAPK9/IRS1/PIK3CB/PTPRF/TRIB3/RPS6KA1/INS/RPS6KA3/PRKCZ/PRKCD/PPP1R3B/AKT3/TBC1D4/PPP1R3C/ACACB/CREB1/PIK3CD/SLC27A5/G6PC2/GFPT2/SLC27A6/G6PC3/PIK3R3/NR1H2/PTEN/PRKAG1/RPS6KA6/AGT/SLC27A4/SREBF1/PPP1CA/GYS1/PRKAB1/PCK2/FOXO1/MLXIPL/PRKCQ/SLC27A3/GYS2/SLC2A1/MLX/CREB3L1/PIK3R2/STAT3/PPARGC1B/PIK3CA/AKT1/IRS2/RPS6KA2/PRKAA1/SLC27A2/NR1H3/PRKCE/PYGM/GFPT1/NFKB1/IL6/G6PC	87
KEGG	hsa00350	Tyrosine metabolism	31/5985	36/8135	0.05784	0.1533	0.1049	MIF/FAHD1/TPO/AOC3/DCT/GOT2/AOX1/ADH1B/FAH/TYR/AOC2/HGD/IL4I1/TYRP1/ALDH3B1/ADH4/TH/DBH/HPD/DDC/TAT/ADH5/ADH7/ALDH3A1/LRTOMT/COMT/ADH1A/ADH6/PNMT/GOT1L1/ADH1C	31
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	23/5985	26/8135	0.05886	0.1548	0.1059	PIGV/MPPE1/PIGU/PIGZ/PIGB/DPM2/PIGX/PIGP/PIGC/PIGA/PGAP1/PIGY/PIGS/PIGN/PIGM/PIGO/PIGQ/PIGH/PIGG/PIGT/PIGK/PIGL/GPLD1	23
KEGG	hsa04921	Oxytocin signaling pathway	122/5985	154/8135	0.06255	0.1624	0.1111	PIK3R5/HRAS/EGFR/KRAS/JUN/CACNG6/MYLK4/PPP1CC/CACNG8/MYL6/MYLK3/ACTG1/CACNG5/ITPR2/ADCY6/PPP1CB/RAF1/PPP3CC/KCNJ2/NFATC4/NOS3/ACTB/NRAS/CACNA2D3/PLCB3/ADCY7/MAP2K5/CALM2/CALM3/PRKAG3/ROCK1/KCNJ6/CACNG2/PPP1R12C/MYLK/OXTR/CALML5/CALML4/CACNG1/ROCK2/KCNJ9/CACNG4/PLA2G4F/MEF2C/CACNG7/CAMK2G/CAMK1D/PPP3CA/CALML3/CALML6/PLA2G4A/ADCY9/CAMK1G/ADCY8/CACNB2/KCNJ4/PRKCA/CALM1/RYR3/SRC/CACNB1/PRKACA/NPR1/MYL6B/CACNA1F/EEF2/RGS2/GUCY1A2/NFATC2/MAPK7/PLCB4/RHOA/CD38/JMJD7-PLA2G4B/MAP2K2/KCNJ3/PRKCG/MYL9/PRKAG1/KCNJ12/KCNJ18/GNAQ/CACNA1C/ITPR3/CACNA2D1/PPP3CB/PPP1CA/FOS/TRPM2/CACNA1D/PRKAB1/ADCY5/MYLK2/PTGS2/GNAI2/CAMK2D/PPP1R12B/RCAN1/PRKACB/PLCB2/RYR2/GNAI3/CACNG3/CACNB3/ITPR1/PIK3CG/PIK3R6/MAPK1/CDKN1A/CACNB4/MAPK3/PRKAA1/GNAO1/MAP2K1/ELK1/ADCY3/PPP3R1/OXT/PLCB1/CAMK2B/PRKACG/EEF2K	122
KEGG	hsa02010	ABC transporters	38/5985	45/8135	0.06287	0.1624	0.1111	ABCC1/ABCA7/ABCA2/ABCD3/ABCB6/ABCC11/ABCC9/TAP2/TAP1/ABCC8/ABCA12/ABCA4/ABCA5/ABCG1/ABCG2/ABCC3/DEFB1/ABCA1/ABCC2/ABCG8/ABCB8/ABCC5/ABCC6/ABCD2/ABCB5/ABCA9/ABCD1/ABCB9/ABCA8/ABCD4/ABCB4/ABCB11/ABCA13/ABCA3/ABCG4/ABCC12/ABCC10/ABCA6	38
KEGG	hsa04152	AMPK signaling pathway	96/5985	120/8135	0.06322	0.1624	0.1111	PPP2R1A/RAB11B/PPP2R3C/CPT1A/STRADB/ADIPOR1/RHEB/PPP2R2D/AKT2/CREB5/RPS6KB2/PPP2R5B/CCNA2/MTOR/PDPK1/RAB14/CREB3L3/CD36/PRKAG3/RAB2A/PPP2R1B/PFKFB4/RPS6KB1/CREB3/MAP3K7/PPP2CA/PPARGC1A/RAB8A/CREB3L4/RAB10/CPT1B/IRS1/IGF1R/PIK3CB/TSC1/ADIPOR2/INS/CPT1C/PFKFB3/STK11/HMGCR/FASN/CCNA1/ULK1/PFKFB2/RPTOR/TSC2/FBP1/AKT3/EIF4EBP1/STRADA/EEF2/ELAVL1/ACACB/SIRT1/CREB1/PFKM/PIK3CD/G6PC2/PPP2R5C/PPP2R3A/LEPR/AKT1S1/G6PC3/PIK3R3/PPP2R2C/MLYCD/PRKAG1/PPP2R5D/PPARG/PPP2R2A/SREBF1/CAB39/PPP2R3B/GYS1/PRKAB1/PCK2/FOXO1/LIPE/GYS2/ACACA/CREB3L1/TBC1D1/CAB39L/PIK3R2/FBP2/PIK3CA/AKT1/IRS2/PRKAA1/FOXO3/PFKP/HNF4A/G6PC/EEF2K/PPP2R5A	96
KEGG	hsa05170	Human immunodeficiency virus 1 infection	166/5985	212/8135	0.06417	0.1636	0.1119	CFL1/TAPBP/GNG2/HRAS/IFNA10/KRAS/IFNA16/NFKBIA/PTK2B/IFNA14/GNG11/GNG4/JUN/B2M/DDB1/TRADD/CCNB3/AKT2/AP1G1/CUL4B/IFNA17/FBXW11/HLA-C/HLA-G/TRAF6/APOBEC3F/FADD/ITPR2/RAF1/PPP3CC/NFATC4/CUL1/NRAS/RPS6KB2/IRAK4/AP1G2/HLA-E/IFNA13/MTOR/GNB2/AP1M2/CALR/IRF3/HLA-A/TLR2/MYD88/CALM2/CALM3/PAK4/MAPK8/TAB1/RPS6KB1/GNG5/LIMK1/HLA-B/MAP3K7/MAP2K3/TNFRSF1A/CFL2/IFNA4/GNG10/APOBEC3D/TAP2/HLA-F/CCR5/CXCR4/CALML5/CHUK/PTK2/CALML4/MAPK9/CUL5/CRK/PIK3CB/BID/IFNA7/GNGT1/IKBKG/FASLG/CASP9/APOBEC3A/APOBEC3A_B/PPP3CA/PAK2/BST2/CALML3/CALML6/GNG7/TLR4/RAC1/CD247/TAP1/PAK1/GNA11/PRKCA/CALM1/APOBEC3B/GNG8/BAX/BAD/AKT3/AP1S3/ATM/CUL4A/NFATC2/IFNA1/TNFRSF1B/PIK3CD/GNG13/CCNB1/BCL2/RAC3/CHEK1/AP1B1/PAK3/MAP2K2/BTRC/PIK3R3/PRKCG/CCNB2/IFNA5/TRAF2/GNAQ/PLCG2/GNG3/LIMK2/ITPR3/AP1S2/RAC2/PPP3CB/APOBEC3C/IFNA8/FOS/IFNA6/PXN/AP1S1/GNAI2/IFNA21/GNAI3/PIK3R2/TAB2/IFNA2/ITPR1/MAPK1/PIK3CA/AKT1/GNG12/IRAK1/MAPK3/MAPK14/GNAO1/MAP2K1/BAK1/MAP2K7/PAK6/MAPK13/TRIM5/PDIA3/PPP3R1/FAS/NFKB1/GNB4/CD3G/AP1M1/CDK1/BCL2L1	166
KEGG	hsa05223	Non-small cell lung cancer	59/5985	72/8135	0.0649	0.1642	0.1123	TP53/RXRB/JAK3/HRAS/ARAF/EGFR/KRAS/BRAF/CDK6/AKT2/EGF/RAF1/NRAS/SOS2/PDPK1/KIF5A/STAT5B/RXRA/PIK3CB/GADD45A/CASP9/ERBB2/RASSF5/EML4/PRKCA/MET/BAX/BAD/GRB2/AKT3/TGFA/CDK4/E2F3/RB1/STK4/STAT5A/PIK3CD/HGF/MAP2K2/PIK3R3/PRKCG/POLK/GADD45B/PLCG2/DDB2/FHIT/KIF5C/PIK3R2/STAT3/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/MAP2K1/BAK1/FOXO3/CDKN2A/SOS1	59
KEGG	hsa04012	ErbB signaling pathway	69/5985	85/8135	0.06656	0.1666	0.1139	HRAS/ARAF/SHC1/EGFR/KRAS/JUN/BRAF/AKT2/GSK3B/EGF/AREG/RAF1/CDKN1B/NRAS/RPS6KB2/SOS2/MTOR/PAK4/MAPK8/NRG4/RPS6KB1/STAT5B/MAP2K4/PTK2/MAPK9/CRK/PIK3CB/CAMK2G/PAK2/ERBB2/PAK1/PRKCA/SRC/BAD/GRB2/AKT3/EIF4EBP1/TGFA/STAT5A/PIK3CD/NRG1/PAK3/NRG2/MAP2K2/PIK3R3/PRKCG/SHC3/GAB1/PLCG2/CAMK2D/PIK3R2/EREG/ERBB4/MAPK1/PIK3CA/AKT1/ERBB3/CDKN1A/MAPK3/ABL1/MAP2K1/ABL2/ELK1/MAP2K7/PAK6/SHC2/CBLB/SOS1/CAMK2B	69
KEGG	hsa01522	Endocrine resistance	79/5985	98/8135	0.06682	0.1666	0.1139	TP53/HRAS/ARAF/SHC1/MDM2/EGFR/KRAS/JUN/BRAF/MMP2/AKT2/SP1/ADCY6/RAF1/CDKN1B/MMP9/NRAS/RPS6KB2/SOS2/ADCY7/MTOR/ESR2/MAPK8/RPS6KB1/PTK2/GPER1/MAPK9/CARM1/NCOR1/IGF1R/PIK3CB/CYP2D6/ERBB2/DLL1/ADCY9/ADCY8/SRC/BAX/PRKACA/BAD/GRB2/AKT3/CDK4/E2F3/RB1/MED1/PIK3CD/NCOA3/ESR1/BCL2/MAP2K2/PIK3R3/SHC3/NOTCH1/BIK/FOS/NOTCH2/ADCY5/CDKN2C/PRKACB/PIK3R2/DLL4/NOTCH4/ABCB11/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/DLL3/MAPK14/MAP2K1/NOTCH3/MAPK13/SHC2/ADCY3/CDKN2A/SOS1/PRKACG	79
KEGG	hsa05212	Pancreatic cancer	62/5985	76/8135	0.06841	0.1692	0.1157	TP53/ARAF/EGFR/KRAS/BRAF/CDK6/SMAD3/JAK1/AKT2/EGF/RAF1/RALBP1/RPS6KB2/SMAD4/MTOR/MAPK8/RPS6KB1/RALB/CHUK/MAPK9/PIK3CB/IKBKG/GADD45A/CASP9/ERBB2/RAC1/CDC42/BAX/BAD/TGFBR1/AKT3/RAD51/TGFA/CDK4/SMAD2/E2F3/RB1/PIK3CD/RAC3/TGFBR2/TGFB1/PLD1/PIK3R3/POLK/GADD45B/STAT1/DDB2/RAC2/PIK3R2/STAT3/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/MAP2K1/BAK1/TGFB3/CDKN2A/NFKB1/RALA/BCL2L1	62
KEGG	hsa04211	Longevity regulating pathway	72/5985	89/8135	0.06937	0.1704	0.1165	TP53/ATF6B/HRAS/EHMT1/ATF2/KRAS/ADIPOR1/RHEB/AKT2/SESN3/ADCY6/ATG5/CREB5/NRAS/RPS6KB2/EIF4E/ADCY7/MTOR/CREB3L3/PRKAG3/RPS6KB1/CREB3/APPL1/CAT/PPARGC1A/CREB3L4/SESN1/IRS1/IGF1R/PIK3CB/TSC1/ADIPOR2/INS/ADCY9/STK11/ADCY8/ULK1/BAX/PRKACA/RPTOR/TSC2/AKT3/EIF4EBP1/ATG13/SIRT1/CREB1/PIK3CD/AKT1S1/PIK3R3/KL/PRKAG1/ATF4/RB1CC1/PPARG/EHMT2/PRKAB1/ADCY5/FOXO1/SESN2/ATG101/PRKACB/CREB3L1/PIK3R2/SOD2/PIK3CA/AKT1/IRS2/PRKAA1/ADCY3/FOXO3/NFKB1/PRKACG	72
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	174/5985	223/8135	0.07114	0.1734	0.1186	HRAS/ARAF/SDHC/PTPN11/ND3/PTPN1/PTPRJ/COX7B/ND6/EGFR/KRAS/NFKBIA/NDUFA10/COX6C/UQCRB/JUN/BRAF/COX7C/ARNT/SDHD/NDUFA1/AKT2/ND2/GSTA3/NDUFB7/CYBA/EGF/NDUFB6/GSTM5/RAF1/MGST1/COX3/UQCRH/UQCRHL/COX4I1/NRAS/NDUFS5/CYP1A1/SLC26A2/SOS2/EPHX1/MAP3K5/CYP1B1/COX1/SLC26A1/KEAP1/PDPK1/NCF1/UQCR10/NDUFA4/NDUFS7/COX2/NDUFA3/NFE2L2/NDUFA11/MAPK8/NDUFA6/COX8A/SLC25A31/NOX1/CAT/NDUFV1/GSTA4/CBR1/MAP2K4/CHUK/NCF2/PTK2/MAPK9/SLC25A4/NDUFA8/PIK3CB/ATP6/NDUFA2/IKBKG/COX5B/COX6B2/UQCRQ/COX6A1/NDUFA13/CYC1/NDUFB1/NDUFA7/RAC1/COX7A1/EPHX2/GSTO1/GSTM3/PRKCD/MET/SRC/UQCRFS1/NDUFB2/MGST2/NDUFB10/HIF1A/SDHB/BAD/NDUFS6/GRB2/AKT3/NDUFS3/ND4/SLC25A6/NDUFV3/SLC26A9/NOX4/AKR1A1/PIK3CD/HGF/SLC25A5/UQCRC1/NQO1/GSTM2/VDAC1/MAP2K2/PRKD2/PLD1/PIK3R3/SLC26A6/NDUFA9/PTEN/AKR1C2/NDUFS4/NDUFB5/UQCRC2/CYP1A2/AKR1C3/CYP2F1/NDUFA4L2/AHR/FOS/EPHX3/PRKD1/GSTA1/COX7A2L/UQCR11/NDUFB9/GSTM1/NDUFV2/NDUFB8/NDUFS1/PIK3R2/HMOX1/AKR1C4/NDUFS2/GSTM4/NDUFB4/COX6B1/SOD2/MAPK1/PIK3CA/AKT1/PPIF/MAPK3/ABL1/MAPK14/ACP1/VDAC2/NDUFB3/MAP2K1/COX5A/CYP2E1/ABL2/PRKD3/MAP2K7/MAPK13/FOXO3/GSTT2/SOS1/NFKB1/NDUFAB1/VDAC3/COX8C	174
KEGG	hsa04962	Vasopressin-regulated water reabsorption	37/5985	44/8135	0.07352	0.1779	0.1217	ARHGDIB/DCTN1/ARHGDIA/VAMP2/RAB11B/DYNLL2/DCTN2/RAB5C/DYNC1H1/RAB5A/DCTN6/ADCY6/CREB5/NSF/CREB3L3/DYNLL1/CREB3/CREB3L4/AVP/ADCY9/PRKACA/AVPR2/AQP2/CREB1/AQP3/DYNC1I2/DYNC1I1/PRKACB/CREB3L1/DYNC1LI1/RAB11A/ARHGDIG/DCTN5/DCTN4/ADCY3/DYNC2LI1/PRKACG	37
KEGG	hsa04670	Leukocyte transendothelial migration	91/5985	114/8135	0.07531	0.181	0.1238	PTPN11/MYL12A/PTK2B/MSN/CLDN7/MMP2/ITGB1/CLDN17/ACTG1/EZR/VASP/CLDN15/CYBA/ARHGAP35/ITGA4/ACTB/MMP9/CLDN3/CLDN20/CLDN19/ACTN4/F11R/NCF1/CLDN8/ROCK1/ACTN1/NCF4/CXCR4/NCF2/PTK2/JAM3/ROCK2/PIK3CB/CLDN5/CTNNA3/CXCL12/CTNNB1/SIPA1/CLDN1/RASSF5/RAC1/TXK/CLDN4/PRKCA/CDC42/ESAM/VAV1/CLDN14/RAP1A/CDH5/PIK3CD/CLDN16/RHOA/ITGAL/PIK3R3/PRKCG/MYL7/MYL9/CLDN11/CLDN10/ITGAM/ITGB2/PLCG2/ITK/RAC2/CD99L2/RAP1B/RHOH/OCLN/PXN/CLDN18/VAV2/MYLPF/CTNNA1/GNAI2/PECAM1/GNAI3/PIK3R2/MYL5/VAV3/MYL12B/CD99/PIK3CA/MAPK14/BCAR1/CLDN23/RAPGEF4/MAPK13/CLDN9/VCL/ARHGAP5	91
KEGG	hsa04916	Melanogenesis	81/5985	101/8135	0.07687	0.183	0.1252	HRAS/DVL3/FZD2/KRAS/WNT2/GSK3B/ADCY6/RAF1/NRAS/PLCB3/ADCY7/CREB3L3/WNT8A/DCT/CALM2/CALM3/ASIP/CREB3/CREBBP/CREB3L4/WNT1/CALML5/CALML4/WNT2B/CAMK2G/TYR/CTNNB1/CALML3/TYRP1/CALML6/MITF/ADCY9/WNT9B/ADCY8/TCF7L1/PRKCA/CALM1/PRKACA/KIT/POMC/FZD3/FZD7/EDNRB/WNT3/CREB1/FZD10/PLCB4/FZD6/MC1R/MAP2K2/WNT5A/EP300/PRKCG/FZD4/FZD8/GNAQ/KITLG/WNT11/WNT9A/ADCY5/WNT7B/GNAI2/CAMK2D/PRKACB/CREB3L1/PLCB2/WNT8B/GNAI3/MAPK1/MAPK3/WNT7A/GNAO1/MAP2K1/WNT5B/WNT4/DVL1/ADCY3/PLCB1/CAMK2B/PRKACG/WNT10A	81
KEGG	hsa05214	Glioma	61/5985	75/8135	0.07726	0.183	0.1252	TP53/HRAS/ARAF/SHC1/MDM2/EGFR/KRAS/BRAF/CDK6/AKT2/EGF/RAF1/NRAS/SOS2/MTOR/CALM2/CALM3/PDGFA/CALML5/CALML4/IGF1R/PIK3CB/GADD45A/CAMK2G/CAMK1D/CALML3/CALML6/CAMK1G/PRKCA/CALM1/BAX/GRB2/AKT3/TGFA/CDK4/E2F3/RB1/PDGFRA/PIK3CD/MAP2K2/PIK3R3/PRKCG/POLK/PTEN/GADD45B/SHC3/PLCG2/DDB2/CAMK2D/PIK3R2/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/MAP2K1/BAK1/SHC2/CDKN2A/SOS1/CAMK2B	61
KEGG	hsa00280	Valine, leucine and isoleucine degradation	40/5985	48/8135	0.08028	0.1871	0.1279	ALDH9A1/HADHB/AGXT2/HMGCS1/ALDH1B1/HSD17B10/ABAT/HMGCL/ACAT1/HIBADH/AACS/BCKDHA/AOX1/OXCT2/AUH/ACADS/ACADM/ACSF3/IVD/ALDH2/HADH/IL4I1/PCCA/ECHS1/DBT/DLD/ALDH6A1/HIBCH/MCCC2/PCCB/OXCT1/ACAD8/ALDH3A2/MCCC1/ALDH7A1/BCAT2/HMGCLL1/BCAT1/EHHADH/HADHA	40
KEGG	hsa05134	Legionellosis	47/5985	57/8135	0.08045	0.1871	0.1279	HSF1/SAR1A/NFKB2/NFKBIA/HSPD1/SAR1B/SEC22B/VCP/HSPA1L/PYCARD/CD14/HSPA1A/HSPA1B/TLR2/MYD88/CR1L/HSPA6/RAB1A/CASP9/CLK1/TLR4/TLR5/HBS1L/APAF1/CLK4/RAB1B/NAIP/CR1/IL18/CASP1/CXCL1/CXCL2/EEF1A2/ITGAM/ITGB2/BNIP3/CXCL3/IL1B/ARF1/CXCL8/HSPA8/EEF1A1/NLRC4/HSPA2/NFKB1/IL6/IL12A	47
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	64/5985	79/8135	0.08065	0.1871	0.1279	HRAS/ARAF/SHC1/EGFR/KRAS/BRAF/JAK1/AKT2/GSK3B/EGF/RAF1/NRAS/RPS6KB2/EIF4E/IL6R/SOS2/FGFR3/MTOR/NF1/BCL2L11/RPS6KB1/PDGFA/IGF1R/PIK3CB/ERBB2/PRKCA/MET/SRC/PDGFC/BAX/BAD/GRB2/AKT3/EIF4EBP1/TGFA/PDGFRA/PIK3CD/HGF/NRG1/FGF2/BCL2/NRG2/MAP2K2/PIK3R3/PRKCG/PTEN/SHC3/GAB1/PLCG2/PDGFD/PIK3R2/STAT3/JAK2/MAPK1/PIK3CA/AKT1/ERBB3/MAPK3/MAP2K1/SHC2/FOXO3/SOS1/IL6/BCL2L1	64
KEGG	hsa05414	Dilated cardiomyopathy	77/5985	96/8135	0.08293	0.188	0.1286	ATP2A3/SGCA/PLN/TPM4/CACNG6/ITGB1/MYH6/CACNG8/MYH7/ITGB5/TPM2/ACTG1/SLC8A3/TPM1/CACNG5/TNNC1/ITGA4/ADCY6/ACTB/ATP2A2/CACNA2D3/ADCY7/ITGB3/ITGA10/ITGA9/ITGA5/TNNI3/CACNG2/ITGB4/CACNG1/ITGA11/CACNG4/CACNG7/ADCY9/ITGA2B/ADCY8/CACNB2/EMD/TPM3/CACNB1/PRKACA/ITGB6/ACTC1/SLC8A2/CACNA1F/DES/SGCD/DMD/SGCB/TGFB1/LAMA2/DAG1/ATP2A1/AGT/CACNA1C/CACNA2D1/CACNA1D/MYL3/ADCY5/PRKACB/RYR2/TNNT2/ITGA1/CACNG3/CACNB3/MYBPC3/CACNB4/ADRB1/TTN/ITGA2/TGFB3/LOC102723407/ADCY3/ITGA3/ITGA8/ITGA6/PRKACG	77
KEGG	hsa04917	Prolactin signaling pathway	57/5985	70/8135	0.08331	0.188	0.1286	HRAS/SHC1/KRAS/AKT2/GSK3B/CISH/CSN2/RAF1/SOCS4/SOCS3/NRAS/CGA/IRF1/SOS2/ESR2/PRL/MAPK8/SOCS7/SOCS1/CCND2/STAT5B/MAPK9/PIK3CB/INS/SRC/TH/GRB2/AKT3/STAT5A/PIK3CD/ESR1/MAP2K2/PIK3R3/SHC3/STAT1/FOS/GCK/TNFRSF11A/GALT/SOCS5/PIK3R2/STAT3/CYP17A1/JAK2/MAPK1/PIK3CA/AKT1/MAPK3/MAPK14/TNFSF11/MAP2K1/LHB/MAPK13/SHC2/FOXO3/SOS1/NFKB1	57
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	57/5985	70/8135	0.08331	0.188	0.1286	PTPN11/EGFR/NFKBIA/JUN/CXCR2/ADAM10/CXCR1/ATP6V1B2/GIT1/ATP6V0C/ATP6V0E1/ATP6V0D2/ATP6V0B/F11R/ATP6V1C2/MAPK8/ATP6V1G3/CSK/ATP6V1H/MAP2K4/CHUK/IGSF5/JAM3/MAPK9/IKBKG/ATP6V0D1/ATP6V1E1/ATP6V1E2/LYN/ATP6V1A/RAC1/ATP6V1F/PAK1/CDC42/ATP6V1C1/MET/SRC/ATP6AP1/ATP6V1B1/CCL5/PTPRZ1/CXCL1/CXCL2/PLCG2/CXCL3/NOD1/TJP1/ATP6V0E2/CXCL8/MAPK14/ATP6V0A1/ATP6V1G2/ATP6V1D/MAPK13/ATP6V1G1/NFKB1/TCIRG1	57
KEGG	hsa05230	Central carbon metabolism in cancer	57/5985	70/8135	0.08331	0.188	0.1286	TP53/GLS/HRAS/EGFR/KRAS/PGAM2/AKT2/IDH1/RAF1/NTRK3/NRAS/FGFR3/PDHA1/HK1/MTOR/PGAM1/G6PD/GLS2/PKM/SLC16A3/PDK1/PIK3CB/NTRK1/HK3/ERBB2/MET/FGFR1/HIF1A/AKT3/KIT/PFKM/PDGFRA/PIK3CD/IDH2/MAP2K2/PIK3R3/SCO2/PTEN/LDHA/GCK/SLC2A1/PIK3R2/LDHB/LDHAL6A/MAPK1/PIK3CA/AKT1/MAPK3/PDHA2/MAP2K1/HK2/SIRT3/SIRT6/SLC1A5/PFKP/LDHAL6B/FLT3	57
KEGG	hsa00531	Glycosaminoglycan degradation	17/5985	19/8135	0.08744	0.196	0.1341	HGSNAT/IDUA/IDS/GUSB/HPSE/HYAL2/NAGLU/SGSH/GLB1/GNS/HEXB/HYAL4/SPAM1/GALNS/HEXA/HPSE2/HYAL1	17
KEGG	hsa05415	Diabetic cardiomyopathy	158/5985	203/8135	0.0928	0.2066	0.1413	SDHC/ATP2A3/ND3/COX7B/ND6/PLN/NDUFA10/COX6C/UQCRB/CPT2/COX7C/MMP2/SDHD/COL1A1/SMAD3/PPP1CC/NDUFA1/AKT2/ND2/NDUFB7/SP1/GSK3B/CYBA/NDUFB6/PPP1CB/COX3/NOS3/MMP9/UQCRH/UQCRHL/COX4I1/NDUFS5/ATP2A2/PDHA1/PLCB3/COX1/MTOR/NCF1/UQCR10/G6PD/CD36/NDUFA4/NDUFS7/COX2/NDUFA3/REN/NDUFA11/MAPK8/NDUFA6/COX8A/SLC25A31/NCF4/PARP1/TNNI3/NDUFV1/CPT1B/NCF2/COL1A2/MAPK9/SLC25A4/IRS1/NDUFA8/PIK3CB/ATP6/NDUFA2/COX5B/COX6B2/GAPDH/CAMK2G/UQCRQ/COX6A1/NDUFA13/CYC1/NDUFB1/MPC1/INS/NDUFA7/PRKCZ/RAC1/AGER/COX7A1/PRKCA/PRKCD/UQCRFS1/NDUFB2/NDUFB10/SDHB/TGFBR1/NDUFS6/AKT3/NDUFS3/ND4/MPC2/TBC1D4/SLC25A6/NDUFV3/SMAD2/PIK3CD/PLCB4/ACE/SLC25A5/UQCRC1/GFPT2/VDAC1/TGFBR2/TGFB1/PIK3R3/PRKCG/NDUFA9/PTEN/NDUFS4/NDUFB5/UQCRC2/ATP2A1/AGT/NDUFA4L2/RAC2/PPP1CA/GYS1/PDK3/COX7A2L/CMA1/AGTR1/UQCR11/NDUFB9/CTSD/NDUFV2/NDUFB8/GYS2/CAMK2D/PDK2/SLC2A1/PLCB2/RYR2/NDUFS1/GSR/PIK3R2/NDUFS2/NDUFB4/COX6B1/PIK3CA/AKT1/PPIF/MAPK14/VDAC2/PDHA2/NDUFB3/COX5A/TGFB3/MAPK13/GFPT1/NFKB1/NDUFAB1/PLCB1/CAMK2B/VDAC3/COX8C/PDK4	158
KEGG	hsa03410	Base excision repair	28/5985	33/8135	0.09678	0.2141	0.1464	LIG3/NEIL2/XRCC1/MPG/PARP4/POLD1/PCNA/PARP1/TDG/SMUG1/POLD4/UNG/POLE3/NEIL3/MBD4/NTHL1/HMGB1/APEX2/POLE4/APEX1/MUTYH/OGG1/PARP3/POLE/POLD3/PARP2/NEIL1/POLD2	28
KEGG	hsa04922	Glucagon signaling pathway	85/5985	107/8135	0.0989	0.2173	0.1486	CPT1A/ATF2/PGAM2/SIK1/AKT2/ITPR2/PPP3CC/CREB5/PDHA1/PLCB3/PHKG1/PGAM1/CREB3L3/PKM/CALM2/CALM3/PRKAG3/PYGL/CREB3/CREBBP/PPARGC1A/CREB3L4/CPT1B/CALML5/PHKB/CALML4/CAMK2G/PPP3CA/CALML3/CALML6/CPT1C/CALM1/PRKACA/FBP1/AKT3/ACACB/SIRT1/CREB1/PFKM/G6PC2/PLCB4/G6PC3/EP300/PRKAG1/PPP4C/ATF4/GNAQ/ITPR3/LDHA/PPP3CB/GCG/GYS1/PRMT1/PRKAB1/GCGR/PCK2/PHKA1/GCK/FOXO1/GYS2/CAMK2D/SLC2A1/PRKACB/ACACA/CREB3L1/PLCB2/SIK2/PHKG2/FBP2/LDHB/ITPR1/LDHAL6A/AKT1/PRKAA1/PDHA2/PHKA2/PYGM/PDE3B/PPP3R1/PFKP/LDHAL6B/PLCB1/CAMK2B/G6PC/PRKACG	85
KEGG	hsa00380	Tryptophan metabolism	35/5985	42/8135	0.09955	0.2173	0.1486	ALDH9A1/ALDH1B1/CYP1A1/AADAT/IDO1/DHTKD1/CYP1B1/ACAT1/AANAT/DLST/CAT/AOX1/TPH2/ALDH2/HADH/IL4I1/ECHS1/DLD/KMO/IDO2/DDC/TPH1/KYNU/ALDH3A2/TDO2/GCDH/ALDH7A1/ALDH8A1/CYP1A2/ACMSD/INMT/ASMT/AOC1/EHHADH/HADHA	35
KEGG	hsa01200	Carbon metabolism	91/5985	115/8135	0.1027	0.2228	0.1524	GLYCTK/SDHC/PGAM2/SDHD/RPEL1/TALDO1/IDH1/CS/MDH2/PDHA1/HK1/FH/ACAT1/PGAM1/G6PD/PKM/RPE/PGLS/DLST/CAT/GOT2/ENO3/ACSS1/ACOX1/ACADS/HAO1/TPI1/HK3/GAPDH/MDH1/CPS1/ALDOA/OGDHL/GPT2/PHGDH/PCCA/ECHS1/TKT/GPT/ACO2/PSAT1/SHMT1/DLD/FBP1/SDHB/ALDH6A1/TKTL2/HIBCH/ESD/ENO1/ACO1/PGK1/PFKM/SDS/PC/SDSL/PCCB/IDH3B/SUCLA2/ADH5/ACSS2/IDH2/ALDOC/PGK2/SUCLG2/ME1/PRPS2/RGN/IDH3G/RPIA/TKTL1/AGXT/ENO2/PKLR/GCK/GCSH/GLUD2/GPI/FBP2/ADPGK/ME2/IDNK/PDHA2/HK2/PRPS1/GLUD1/ME3/SHMT2/PFKP/GOT1L1/DLAT	91
KEGG	hsa05231	Choline metabolism in cancer	78/5985	98/8135	0.1045	0.2252	0.154	SLC22A3/HRAS/PIP5K1A/EGFR/KRAS/DGKE/JUN/RHEB/AKT2/SP1/EGF/SLC22A4/RAF1/LYPLA1/NRAS/RPS6KB2/SOS2/MTOR/PDPK1/SLC5A7/DGKA/MAPK8/WASF3/RPS6KB1/DGKK/PDGFA/MAPK9/PIK3CB/TSC1/PLA2G4F/PCYT1B/PLA2G4A/PIP5K1C/PCYT1A/RAC1/CHPT1/SLC44A3/PRKCA/CHKB/PDGFC/TSC2/HIF1A/GRB2/AKT3/EIF4EBP1/PDGFRA/DGKG/PIK3CD/PIP5K1B/RAC3/JMJD7-PLA2G4B/MAP2K2/PLD1/PIK3R3/DGKZ/PRKCG/WASF1/SLC22A2/RAC2/SLC44A5/FOS/WASF2/PDGFD/CHKA/DGKQ/PIK3R2/WAS/MAPK1/PIK3CA/AKT1/MAPK3/DGKH/MAP2K1/DGKB/SOS1/SLC44A2/GPCPD1/SLC44A4	78
KEGG	hsa04664	Fc epsilon RI signaling pathway	55/5985	68/8135	0.1059	0.2256	0.1543	HRAS/KRAS/AKT2/RAF1/NRAS/SOS2/ALOX5AP/CSF2/PDPK1/FCER1A/MAPK8/IL3/MAP2K3/SYK/MAP2K4/MAPK9/IL5/PIK3CB/PLA2G4F/LYN/PLA2G4A/RAC1/MS4A2/PRKCA/VAV1/IL4/GRB2/GAB2/BTK/AKT3/ALOX5/FCER1G/PIK3CD/RAC3/JMJD7-PLA2G4B/MAP2K2/PIK3R3/PLCG2/RAC2/FYN/VAV2/PIK3R2/VAV3/MAPK1/PIK3CA/AKT1/MAPK3/MAPK14/MAP2K1/LCP2/MAP2K7/INPP5D/LOC102723407/MAPK13/SOS1	55
KEGG	hsa05202	Transcriptional misregulation in cancer	150/5985	193/8135	0.106	0.2256	0.1543	AFF1/TP53/MAX/TMPRSS2/RXRB/ZBTB17/FUS/MDM2/KLF3/SIN3A/LYL1/RUNX1/ELK4/CDK9/TLX1/MEIS1/ATF1/SP1/PRCC/RUNX2/CDKN1B/JMJD1C/DEFA1/DEFA1B/DEFA3/MMP9/PAX5/DUSP6/DOT1L/KDM6A/SS18/CSF2/CCNA2/IL1R2/CEBPA/SLC45A3/CD14/HHEX/PBX1/CEBPB/DEFA6/IL3/CCND2/RXRA/LDB1/TSPAN7/MLLT1/FEV/PML/BCL6/PDGFA/PTK2/SIX1/NCOR1/IGF1R/PER2/NTRK1/GADD45A/MEF2C/TRAF1/KMT2A/TLX3/TCF3/MITF/SUPT3H/FLT1/CCNA1/EWSR1/DEFA4/GZMB/MET/NUPR1/BAX/NR4A3/ASPSCR1/PAX7/CD40/EYA1/PTCRA/SS18L1/CD86/ATM/TFE3/BAIAP3/CCNT2/PROM1/LMO2/JUP/MYCN/HPGD/TGFBR2/ETV7/POLK/MEN1/GADD45B/ITGAM/SPINT1/FLI1/BCL11B/PPARG/DDB2/HDAC2/IL2RB/PLAT/PAX3/IGFBP3/SMAD1/CCNT1/FOXO1/HOXA9/FCGR1A/CDKN2C/NFKBIZ/SIX4/RARA/PBX3/RUNX1T1/ETV4/DDIT3/CXCL8/CEBPE/DEFA5/CSF1R/ETV1/MLLT3/CDKN1A/NGFR/DDX5/HDAC1/BCL2A1/ELANE/REL/MMP3/SSX2B/MAF/BAK1/ETV5/CDK14/WT1/BMP2K/LOC102723407/HOXA10/NFKB1/ID2/ETV6/IL6/FLT3/MPO/BCL2L1/BIRC3	150
KEGG	hsa04972	Pancreatic secretion	81/5985	102/8135	0.1068	0.2257	0.1544	ATP2A3/SCT/SLC4A2/ATP1B3/CA2/CTRL/CPA3/CELA2A/ITPR2/ADCY6/CELA2B/ATP2A2/PLCB3/ADCY7/BST1/PLA2G2D/RAB8A/CPA1/PLA2G1B/PLA2G2F/PLA2G2A/ATP1B2/ADCY9/CLCA1/RAC1/PLA2G12A/ATP1A3/ADCY8/PRKCA/CPB1/RAB3D/ATP1A1/SLC12A2/RAP1A/SCTR/PLCB4/RHOA/CD38/CELA3A/ATP2B3/PRKCG/CLCA4/GNAQ/PLA2G2E/ATP2A1/ATP2B4/ATP2B2/ITPR3/PRSS2/CLCA2/RAP1B/PLA2G12B/CTRB1/AMY1A/AMY1B/AMY1C/AMY2A/CCKAR/ADCY5/ATP2B1/CHRM3/PLA2G3/TRPC1/KCNQ1/ATP1A2/PLCB2/RYR2/SLC9A1/AMY2B/PNLIPRP1/SLC4A4/ITPR1/RAB11A/PLA2G10/PRSS1/CCK/PLA2G5/CPA2/ADCY3/PLCB1/CPB2	81
KEGG	hsa00061	Fatty acid biosynthesis	16/5985	18/8135	0.1082	0.2274	0.1555	MECR/ACSL1/CBR4/ACSF3/FASN/ACSL6/OXSM/ACACB/ACSL4/ACSBG2/ACSL3/ACACA/HSD17B8/ACSBG1/MCAT/OLAH	16
KEGG	hsa04024	cAMP signaling pathway	171/5985	221/8135	0.1094	0.2285	0.1562	ATP2A3/PLN/PDE4C/ATP1B3/NFKBIA/JUN/BRAF/CHRM2/FFAR2/PPP1CC/AKT2/ADCYAP1/SSTR2/SSTR5/ADCY6/PPP1CB/RAF1/CREB5/CGA/HCAR3/HTR1D/ATP2A2/ADCY7/PDE4D/DRD2/GRIN3A/CREB3L3/GPHA2/CALM2/CALM3/MAPK8/EDN2/SUCNR1/ROCK1/PDE4A/ADCYAP1R1/CREB3/CREBBP/GABBR1/TNNI3/HTR1B/CREB3L4/CNGA1/ACOX1/OXTR/CALML5/GIP/CALML4/MAPK9/PPP1R1B/ROCK2/PIK3CB/CAMK2G/PTGER2/ATP1B2/CALML3/CALML6/GRIN2B/ADCY9/AMH/ARAP3/RAC1/ORAI1/ATP1A3/ADCY8/PDE4B/PAK1/CALM1/GABBR2/VAV1/PRKACA/VIP/MC2R/NPR1/BAD/GIPR/ATP1A1/AKT3/DRD5/POMC/GRIN1/CACNA1F/PLCE1/HCN2/FSHR/CREB1/GRIN2A/F2R/RAP1A/PIK3CD/CHRM1/RHOA/RAC3/ADORA2A/MAP2K2/EP300/ATP2B3/PLD1/PIK3R3/GPHB5/GLI3/MYL9/EDN3/HTR4/CNGA4/HHIP/GLI1/CRHR2/GHSR/BDNF/ATP2A1/ATP2B4/CACNA1C/ATP2B2/EDNRA/RAC2/PPP1CA/GCG/FOS/CNGB1/PDE3A/ADORA1/RAP1B/CACNA1D/TSHB/CNGB3/ADCY5/ATP2B1/VAV2/HCAR1/LIPE/GNAI2/CAMK2D/GRIA4/ADRB2/ATP1A2/PRKACB/CREB3L1/RYR2/SLC9A1/GNAI3/PIK3R2/GRIN2C/VAV3/GRIA2/HCN4/MAPK1/PIK3CA/AKT1/FXYD1/GRIN2D/FSHB/ADRB1/MAPK3/TSHR/MAP2K1/PTCH1/GLP1R/DRD1/RAPGEF4/PDE3B/VIPR2/LHB/SST/TIAM1/ADCY3/OXT/HTR1F/NFKB1/CAMK2B/PRKACG	171
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	71/5985	89/8135	0.1104	0.229	0.1566	NFKBIB/HRAS/PTPN11/EGFR/KRAS/NFKBIA/JUN/JAK1/AKT2/TRAF6/EGF/RAF1/PPP3CC/NRAS/RPS6KB2/CSNK2A1/MTOR/CSNK2B/TICAM2/TLR2/MYD88/IFNGR2/RPS6KB1/MAP2K3/CHUK/PIK3CB/IKBKG/IFNGR1/PPP3CA/BATF/MAP3K3/EML4/TLR4/CD247/LCK/HIF1A/AKT3/BATF2/NFATC2/PIK3CD/CD274/MAP2K2/PIK3R3/TIRAP/PTEN/STAT1/BATF3/IFNG/TICAM1/TLR9/PPP3CB/FOS/PRKCQ/PIK3R2/STAT3/JAK2/MAPK1/PIK3CA/AKT1/ZAP70/MAPK3/MAPK14/MAP2K1/CSNK2A2/MAPK13/PPP3R1/NFKB1/PTPN6/PDCD1/CD3G/CD28	71
KEGG	hsa04912	GnRH signaling pathway	74/5985	93/8135	0.113	0.2307	0.1578	HRAS/EGFR/KRAS/MMP14/PTK2B/JUN/MMP2/ITPR2/ADCY6/RAF1/NRAS/CGA/SOS2/PLCB3/ADCY7/CALM2/CALM3/MAPK8/MAP2K3/CALML5/MAP2K4/CALML4/MAPK9/PLA2G4F/MAP3K4/CAMK2G/MAP3K2/CALML3/EGR1/CALML6/MAP3K3/PLA2G4A/ADCY9/ADCY8/GNA11/PRKCA/CALM1/CDC42/PRKCD/SRC/PRKACA/GRB2/CACNA1F/MAPK7/PLCB4/JMJD7-PLA2G4B/MAP2K2/PLD1/ATF4/GNAQ/CACNA1C/ITPR3/CACNA1D/ADCY5/CAMK2D/PRKACB/PLCB2/GNRHR/GNRH1/ITPR1/MAPK1/FSHB/MAPK3/MAPK14/MAP2K1/ELK1/LHB/MAP2K7/MAPK13/ADCY3/SOS1/PLCB1/CAMK2B/PRKACG	74
KEGG	hsa03040	Spliceosome	115/5985	147/8135	0.1139	0.2307	0.1578	DDX42/SNRPE/SRSF3/FUS/HNRNPU/SNRNP70/DDX39B/WBP11/XAB2/U2AF2/LSM3/PRPF3/AQR/MAGOH/SNRPG/NCBP1/SRSF2/DDX23/TRA2B/CHERP/LSM5/U2AF1L4/ACIN1/CRNKL1/CDC5L/TRA2A/SNRPD1/SNRPB/SNRNP27/HNRNPM/EIF4A3/RBM8A/TCERG1/HNRNPA3/DHX15/SNRPA1/HSPA1L/PCBP1/SART1/SRSF6/SRSF4/HSPA1A/HSPA1B/DHX38/SRSF1/HSPA6/U2SURP/DDX46/SNRPD2/PRPF38A/CWC15/CDC40/DHX16/PRPF18/SNRNP40/SF3A3/SYF2/BCAS2/SRSF5/HNRNPA1/PHF5A/MAGOHB/NCBP2/TXNL4A/SNRPC/RBM25/USP39/SRSF10/PRPF6/PRPF8/PPIL1/SF3B1/RP9/SRSF9/ISY1/LSM4/SF3B2/PRPF31/SNRNP200/PLRG1/ALYREF/SNRPB2/SNRPA/PRPF19/THOC1/RBM22/SF3B5/RBM17/SF3B4/HNRNPC/PUF60/BUD31/SNW1/SLU7/SNRPF/SRSF8/PRPF4/SF3A1/DHX8/HNRNPA1L2/PQBP1/LSM7/LSM6/PRPF40B/ISY1-RAB43/SMNDC1/DDX5/PPIH/HSPA8/U2AF1/CTNNBL1/HSPA2/PRPF38B/CCDC12/RBMX	115
KEGG	hsa04136	Autophagy - other	27/5985	32/8135	0.1141	0.2307	0.1578	ATG16L1/PIK3R4/ATG4D/ATG2B/GABARAPL2/ATG5/MTOR/ATG4C/BECN1/PPP2CA/GABARAPL1/GABARAP/WIPI2/ATG12/PIK3C3/ATG7/RPTOR/ATG13/ATG9B/IGBP1/ATG4A/ATG101/ATG2A/ATG9A/ATG4B/ATG10/MLST8	27
KEGG	hsa04623	Cytosolic DNA-sensing pathway	51/5985	63/8135	0.1147	0.2307	0.1578	NFKBIB/IFNA10/IFNA16/NFKBIA/POLR2K/IFNA14/IFNA17/POLR3K/POLR3G/IFNA13/PYCARD/IRF3/POLR3F/IFNA4/MAVS/CHUK/POLR3E/IFNA7/IRF7/IKBKG/POLR2F/POLR2H/POLR2E/POLR3A/ADAR/POLR3B/RIPK3/CXCL10/POLR3C/TREX1/IFNA1/CCL5/IL18/CASP1/AIM2/IKBKE/IFNA5/IL1B/POLR1D/IFNA8/IFNA6/POLR3H/IFNA21/IFNA2/DDX58/ZBP1/POLR3D/POLR1C/NFKB1/CCL4/IL6	51
KEGG	hsa05219	Bladder cancer	34/5985	41/8135	0.1153	0.2307	0.1578	DAPK3/TP53/HRAS/ARAF/MDM2/EGFR/KRAS/BRAF/MMP2/RPS6KA5/EGF/RAF1/MMP9/NRAS/FGFR3/TYMP/ERBB2/SRC/DAPK2/CDK4/E2F3/RB1/MAP2K2/CDH1/MMP1/CXCL8/MAPK1/CDKN1A/MAPK3/MAP2K1/THBS1/UPK3A/CDKN2A/DAPK1	34
KEGG	hsa04713	Circadian entrainment	77/5985	97/8135	0.1153	0.2307	0.1578	GNG2/PER1/GNG11/GNG4/RPS6KA5/ADCYAP1/ADCY6/CACNA1H/PLCB3/ADCY7/PRKG1/GNB2/CALM2/CALM3/GNG5/ADCYAP1R1/KCNJ6/GNG10/CALML5/CALML4/KCNJ9/PER2/GNGT1/NOS1/CAMK2G/CALML3/NOS1AP/CALML6/GRIN2B/GNG7/ADCY9/ADCY8/PRKCA/CALM1/RYR3/GNG8/PRKACA/GRIN1/CACNA1G/GUCY1A2/CREB1/GRIN2A/GNG13/PLCB4/KCNJ3/PRKCG/PER3/GNAQ/GNG3/CACNA1C/ITPR3/FOS/CACNA1D/ADCY5/MTNR1A/GNAI2/CAMK2D/GRIA4/PRKACB/PLCB2/RYR2/GNAI3/GRIN2C/RASD1/GRIA2/ITPR1/MAPK1/GNG12/GRIN2D/MAPK3/CACNA1I/GNAO1/ADCY3/GNB4/PLCB1/CAMK2B/PRKACG	77
KEGG	hsa03320	PPAR signaling pathway	60/5985	75/8135	0.1262	0.251	0.1716	RXRB/CPT1A/DBI/CPT2/HMGCS1/PPARD/FABP5/ACSL1/FABP3/CYP27A1/PDPK1/CD36/CYP8B1/APOA5/UBC/RXRA/SLC27A1/SCP2/ACOX1/ACADM/CPT1B/APOC3/PLIN2/PLIN1/APOA1/CPT1C/AQP7/LOC100509620/ACSL6/APOA2/PLIN5/ACSL4/SLC27A5/GK/PLTP/ACSBG2/SLC27A6/ANGPTL4/ACSL3/ME1/FABP6/FABP2/PPARG/SLC27A4/PLIN4/PCK2/FABP1/FABP7/MMP1/FABP4/SORBS1/EHHADH/OLR1/GK2/SLC27A2/NR1H3/ACSBG1/ME3/ACADL/FADS2	60
KEGG	hsa05150	Staphylococcus aureus infection	76/5985	96/8135	0.127	0.251	0.1717	KRT23/FPR1/FPR2/PTAFR/DEFA1/DEFA1B/DEFA3/SELP/KRT38/KRT10/C4A/C4B/KRT31/KRT37/CFD/CFB/CAMP/DEFB4A/DEFB4B/FCGR3B/KRT19/DEFA6/KRT15/DEFB103A/DEFB103B/KRT33B/KRT9/KRT32/KRT14/KRT34/LOC100653049/FCGR2B/HLA-DPA1/FGG/KRT33A/HLA-DMB/DEFA4/C5AR1/KRT40/FCGR3A/HLA-DRB1/HLA-DQA2/KRT13/KRT16/HLA-DRA/SELPLG/KRT24/HLA-DMA/ITGAL/DEFB1/HLA-DQB1/IL10/PLG/ITGAM/ITGB2/HLA-DOB/KRT35/HLA-DRB4/HLA-DOA/MBL2/FPR3/FCGR1A/C1QC/HLA-DPB1/C3AR1/C2/KRT12/DEFA5/KRT27/FCGR2A/MASP2/C5/HLA-DQA1/LOC102723407/KRT25/KRT20	76
KEGG	hsa00900	Terpenoid backbone biosynthesis	19/5985	22/8135	0.1283	0.2511	0.1717	IDI1/HMGCS1/RCE1/ZMPSTE24/ACAT1/DHDDS/MVD/HMGCR/NUS1/FNTA/FDPS/GGPS1/PDSS1/MVK/PCYOX1/FNTB/ICMT/PDSS2/PMVK	19
KEGG	hsa04213	Longevity regulating pathway - multiple species	50/5985	62/8135	0.129	0.2511	0.1717	HRAS/CRYAB/KRAS/AKT2/ADCY6/ATG5/NRAS/RPS6KB2/ADCY7/MTOR/HSPA1L/HSPA1A/HSPA1B/PRKAG3/RPS6KB1/HSPA6/CAT/IRS1/IGF1R/PIK3CB/CLPB/EIF4EBP2/INS/ADCY9/ADCY8/PRKACA/RPTOR/AKT3/SIRT1/PIK3CD/AKT1S1/PIK3R3/PRKAG1/HDAC2/PRKAB1/ADCY5/FOXO1/PRKACB/PIK3R2/SOD2/PIK3CA/AKT1/IRS2/HDAC1/PRKAA1/HSPA8/ADCY3/FOXO3/HSPA2/PRKACG	50
KEGG	hsa04672	Intestinal immune network for IgA production	40/5985	49/8135	0.1293	0.2511	0.1717	ITGA4/MADCAM1/TNFSF13B/AICDA/TNFSF13/CXCR4/IL5/CD80/HLA-DPA1/CXCL12/HLA-DMB/IL4/HLA-DRB1/CD40/HLA-DQA2/HLA-DRA/CD86/PIGR/HLA-DMA/CD40LG/CCL28/CCR9/HLA-DQB1/IL2/TNFRSF17/TGFB1/CCL25/IL10/HLA-DOB/HLA-DRB4/HLA-DOA/TNFRSF13B/HLA-DPB1/CCR10/IL15/IL15RA/HLA-DQA1/LOC102723407/CD28/IL6	40
KEGG	hsa04064	NF-kappa B signaling pathway	82/5985	104/8135	0.1311	0.2526	0.1727	NFKB2/NFKBIA/TRADD/TRAF6/LTB/XIAP/IRAK4/CSNK2A1/BLNK/CFLAR/CSNK2B/TNFSF14/TICAM2/TNFSF13B/CD14/MYD88/TNFAIP3/TAB1/EDAR/MAP3K7/PARP1/TNFRSF1A/SYK/CHUK/TRIM25/IKBKG/GADD45A/TAB3/TRAF1/EDA2R/CXCL12/LYN/CCL21/RELB/TLR4/CARD10/PIAS4/LCK/CD40/BTK/PIDD1/ATM/CD40LG/BCL2/CXCL1/CARD14/CXCL2/TIRAP/MALT1/IL1R1/GADD45B/TRAF2/PLCG2/CYLD/CXCL3/IL1B/TICAM1/LY96/CARD11/EDARADD/TRAF3/CCL13/PRKCQ/PTGS2/TNFRSF11A/LTA/LBP/TAB2/DDX58/CXCL8/ZAP70/UBE2I/IRAK1/BCL2A1/TNFSF11/CSNK2A2/ERC1/LOC102723407/NFKB1/CCL4/BCL2L1/BIRC3	82
KEGG	hsa00910	Nitrogen metabolism	15/5985	17/8135	0.1334	0.2526	0.1727	CA1/CA2/CA4/CPS1/CA5B/CA14/GLUL/CA8/CA12/CA9/CA5A/CA13/CA7/GLUD2/GLUD1	15
KEGG	hsa00052	Galactose metabolism	26/5985	31/8135	0.1339	0.2526	0.1727	B4GALT1/UGP2/GALE/MGAM/HK1/PGM1/LALBA/HK3/GLA/GLB1/GALK1/PFKM/PGM2/GALM/G6PC2/G6PC3/LCT/GCK/GALT/AKR1B1/B4GALT2/HK2/GAA/AKR1B10/PFKP/G6PC	26
KEGG	hsa00410	beta-Alanine metabolism	26/5985	31/8135	0.1339	0.2526	0.1727	ALDH9A1/ALDH1B1/ABAT/AOC3/DPYD/CSAD/ACOX1/ACADS/ALDH2/AOC2/ECHS1/ALDH3B1/CNDP1/ALDH6A1/HIBCH/SMOX/ALDH3A2/MLYCD/GADL1/ALDH7A1/CNDP2/ALDH3A1/DPYS/EHHADH/HADHA/GAD2	26
KEGG	hsa05310	Asthma	26/5985	31/8135	0.1339	0.2526	0.1727	EPX/FCER1A/RNASE3/IL3/IL5/HLA-DPA1/MS4A2/HLA-DMB/IL4/HLA-DRB1/CD40/HLA-DQA2/HLA-DRA/HLA-DMA/CD40LG/FCER1G/HLA-DQB1/IL10/HLA-DOB/HLA-DRB4/HLA-DOA/HLA-DPB1/PRG2/HLA-DQA1/LOC102723407/IL9	26
KEGG	hsa04668	TNF signaling pathway	88/5985	112/8135	0.1346	0.2526	0.1727	JUNB/ATF6B/ATF2/MMP14/PGAM5/NFKBIA/CXCL5/JUN/RPS6KA5/TRADD/AKT2/FADD/SOCS3/CX3CL1/CREB5/MMP9/IRF1/MAP3K5/CSF2/CFLAR/CREB3L3/NOD2/ITCH/TNFAIP3/CEBPB/MAPK8/TAB1/MLKL/LIF/CREB3/MAP3K7/MAP2K3/TNFRSF1A/CREB3L4/BAG4/MAP2K4/CHUK/MAPK9/PIK3CB/IKBKG/DNM1L/TAB3/TRAF1/SELE/RIPK3/AKT3/CXCL10/BCL3/CREB1/CCL5/TNFRSF1B/PIK3CD/CCL2/CXCL1/PIK3R3/CXCL2/ATF4/TRAF2/CASP10/CCL20/CXCL3/IL1B/CSF1/IL18R1/FOS/TRAF3/PTGS2/LTA/CREB3L1/DAB2IP/PIK3R2/TAB2/VEGFC/MAPK1/IL15/PIK3CA/AKT1/MAPK3/MAPK14/MAP2K1/CXCL6/MMP3/MAP2K7/MAPK13/FAS/NFKB1/IL6/BIRC3	88
KEGG	hsa04935	Growth hormone synthesis, secretion and action	93/5985	119/8135	0.1495	0.279	0.1908	JUNB/ATF6B/HRAS/SHC1/ATF2/KRAS/AKT2/SSTR2/GSK3B/SSTR5/ITPR2/ADCY6/GH2/RAF1/SOCS3/CREB5/NRAS/SOS2/PLCB3/ADCY7/MTOR/CREB3L3/IGFALS/MAPK8/SOCS1/CREB3/STAT5B/MAP2K3/CREBBP/CREB3L4/MAP2K4/PTK2/MAPK9/GHRHR/IRS1/CRK/PIK3CB/GH1/ADCY9/ADCY8/GNA11/PRKCA/PRKACA/POU1F1/GRB2/AKT3/CACNA1F/CSH2/CREB1/STAT5A/PIK3CD/PLCB4/MAP2K2/EP300/PIK3R3/PRKCG/GHRH/SHC3/STAT1/ATF4/GNAQ/PLCG2/GHSR/CACNA1C/ITPR3/FOS/CACNA1D/IGFBP3/ADCY5/GNAI2/PRKACB/CREB3L1/PLCB2/GNAI3/PIK3R2/STAT3/JAK2/ITPR1/MAPK1/PIK3CA/AKT1/IRS2/MAPK3/MAPK14/BCAR1/MAP2K1/SST/MAPK13/SHC2/ADCY3/SOS1/PLCB1/PRKACG	93
KEGG	hsa05410	Hypertrophic cardiomyopathy	71/5985	90/8135	0.151	0.2802	0.1917	ATP2A3/SGCA/TPM4/CACNG6/ITGB1/MYH6/CACNG8/MYH7/ITGB5/TPM2/ACTG1/SLC8A3/TPM1/CACNG5/TNNC1/ITGA4/ACTB/ATP2A2/CACNA2D3/ITGB3/ITGA10/PRKAG3/ITGA9/ITGA5/TNNI3/CACNG2/ITGB4/CACNG1/ITGA11/CACNG4/CACNG7/ITGA2B/CACNB2/EMD/TPM3/CACNB1/ITGB6/ACTC1/SLC8A2/CACNA1F/DES/ACE/SGCD/DMD/SGCB/TGFB1/LAMA2/PRKAG1/DAG1/ATP2A1/AGT/CACNA1C/CACNA2D1/CACNA1D/MYL3/PRKAB1/RYR2/TNNT2/ITGA1/CACNG3/CACNB3/MYBPC3/CACNB4/TTN/ITGA2/PRKAA1/TGFB3/ITGA3/ITGA8/ITGA6/IL6	71
KEGG	hsa05031	Amphetamine addiction	55/5985	69/8135	0.1524	0.2813	0.1924	ATF6B/ATF2/FOSB/JUN/PPP1CC/PPP1CB/PPP3CC/SLC18A2/CREB5/GRIN3A/SLC6A3/CREB3L3/CALM2/CALM3/CREB3/CREB3L4/CALML5/CALML4/PPP1R1B/CAMK2G/PPP3CA/CALML3/CALML6/GRIN2B/PRKCA/CALM1/STX1A/TH/PRKACA/GRIN1/SIRT1/CREB1/GRIN2A/DDC/PRKCG/ATF4/CACNA1C/HDAC2/PPP3CB/PPP1CA/FOS/CACNA1D/ADCY5/CAMK2D/GRIA4/PRKACB/CREB3L1/GRIN2C/GRIA2/GRIN2D/HDAC1/DRD1/PPP3R1/CAMK2B/PRKACG	55
KEGG	hsa00770	Pantothenate and CoA biosynthesis	18/5985	21/8135	0.1542	0.2829	0.1935	PANK2/ALDH1B1/ENPP3/VNN2/DPYD/PPCDC/CSAD/AASDHPPT/ALDH2/VNN1/PPCS/ALDH3A2/GADL1/BCAT2/DPYS/COASY/BCAT1/PANK1	18
KEGG	hsa01524	Platinum drug resistance	58/5985	73/8135	0.1557	0.283	0.1935	TP53/MDM2/AKT2/MLH1/GSTA3/MSH6/XPA/FADD/GSTM5/MGST1/XIAP/MAP3K5/BRCA1/PDPK1/REV3L/SLC31A1/ATP7B/GSTA4/PIK3CB/BID/FASLG/CASP9/ERBB2/GSTO1/GSTM3/PMAIP1/BAX/APAF1/MGST2/BAD/AKT3/ATM/PIK3CD/BCL2/GSTM2/PIK3R3/ABCC2/POLH/TOP2B/GSTA1/GSTM1/ATP7A/PIK3R2/GSTM4/MAPK1/PIK3CA/AKT1/CDKN1A/MAPK3/GSTP1/BAK1/FAS/GSTT2/BIRC5/CDKN2A/ERCC1/BCL2L1/BIRC3	58
KEGG	hsa05142	Chagas disease	80/5985	102/8135	0.1567	0.283	0.1935	PPP2R1A/NFKBIA/JUN/PPP2R2D/AKT2/TRAF6/FADD/TLR6/IRAK4/PLCB3/CFLAR/CALR/TLR2/MYD88/MAPK8/PPP2R1B/IFNGR2/PPP2CA/TNFRSF1A/MAP2K4/CHUK/MAPK9/PIK3CB/GNA15/IKBKG/IFNGR1/FASLG/TLR4/CD247/GNA11/GNAL/KNG1/TGFBR1/AKT3/SMAD2/CCL5/PIK3CD/PLCB4/NOS2/ACE/CCL2/TGFBR2/IL2/TGFB1/GNA14/PIK3R3/IL10/PPP2R2C/GNAQ/IFNG/PPP2R2A/IL1B/TICAM1/TLR9/FOS/GNAI2/C1QC/PLCB2/GNAI3/PIK3R2/CXCL8/MAPK1/PIK3CA/AKT1/SERPINE1/IRAK1/MAPK3/CCL3/CCL3L1/CCL3L3/MAPK14/GNAO1/TGFB3/MAPK13/FAS/NFKB1/CD3G/IL6/PLCB1/IL12A	80
KEGG	hsa05146	Amoebiasis	80/5985	102/8135	0.1567	0.283	0.1935	RAB7A/ARG2/LAMB1/RAB5C/RAB5A/COL1A1/C8G/ARG1/SERPINB3/PLCB3/CD1A/SERPINB4/CSF2/ACTN4/IL1R2/CD1B/CD14/TLR2/ACTN1/HSPB1/PTK2/COL1A2/COL4A1/CD1D/PIK3CB/GNA15/LAMC1/CD1C/TLR4/COL4A2/GNA11/PRKCA/GNAL/PRDX1/PRKACA/LAMB2/PIK3CD/CTSG/PLCB4/NOS2/MUC2/SERPINB6/CXCL1/LAMB3/TGFB1/GNA14/PIK3R3/PRKCG/IL10/CXCL2/LAMA2/IL1R1/SERPINB13/C8B/ITGAM/ITGB2/RAB7B/GNAQ/CXCL3/IFNG/IL1B/C8A/FN1/PRKACB/PLCB2/LAMA5/PIK3R2/CXCL8/PIK3CA/LAMC2/LAMC3/TGFB3/LOC102723407/NFKB1/SERPINB10/IL6/PLCB1/IL12A/PRKACG/VCL	80
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	61/5985	77/8135	0.1586	0.2848	0.1947	ATP2A3/SGCA/CACNG6/ITGB1/CACNG8/ITGB5/ACTG1/SLC8A3/CACNG5/ITGA4/ACTB/ATP2A2/CACNA2D3/ITGB3/ITGA10/ITGA9/ITGA5/ACTN2/CACNG2/ITGB4/CACNG1/ITGA11/CACNG4/ACTN3/CACNG7/CTNNA3/DSP/CTNNB1/ITGA2B/CACNB2/EMD/TCF7L1/DSC2/CACNB1/ITGB6/SLC8A2/CACNA1F/DES/JUP/SGCD/DMD/SGCB/LAMA2/DAG1/ATP2A1/CACNA1C/CDH2/CACNA2D1/CACNA1D/CTNNA1/GJA1/RYR2/ITGA1/CACNG3/CACNB3/PKP2/CACNB4/ITGA2/ITGA3/ITGA8/ITGA6	61
KEGG	hsa04610	Complement and coagulation cascades	67/5985	85/8135	0.1635	0.2919	0.1996	F7/CD46/C7/C8G/F13A1/VWF/F2RL2/C4A/C4B/CFD/CFB/A2M/CR1L/CR2/VSIG4/C6/F8/F10/PROS1/F9/CLU/FGG/THBD/VTN/SERPIND1/CFHR4/SERPING1/SERPINB2/F5/C4BPA/C5AR1/FGA/KNG1/CR1/F2R/CFHR2/CD59/F2/F11/SERPINA1/PLG/C8B/ITGAM/ITGB2/F3/KLKB1/PLAUR/PLAT/F13B/MBL2/CD55/C8A/C1QC/CFHR5/C3AR1/PROCR/C2/SERPINF2/CFHR3/SERPINE1/MASP2/C5/PROC/FGB/CFHR1/BDKRB1/CPB2	67
KEGG	hsa04110	Cell cycle	98/5985	126/8135	0.1643	0.2919	0.1996	YWHAE/TP53/ANAPC15/ZBTB17/MDM2/SMC1A/CDK6/CCNH/SMAD3/SKP2/CCNB3/YWHAB/GSK3B/YWHAG/CDKN1B/MCM4/CUL1/SMAD4/PLK1/ORC2/CCNA2/ANAPC16/PCNA/ANAPC13/FZR1/ESPL1/ANAPC5/CCND2/CDC23/CDC14A/CREBBP/CCNE2/RBL1/TFDP1/PTTG2/SMC1B/GADD45A/PRKDC/CCNA1/MAD2L2/STAG2/ORC6/ORC1/CDC45/ANAPC7/ATM/CDK4/ANAPC10/SMAD2/E2F3/RB1/CCNB1/CHEK1/TGFB1/EP300/CCNB2/ANAPC2/CDK2/GADD45B/PKMYT1/CDKN1C/MAD1L1/YWHAQ/SFN/TFDP2/MCM7/HDAC2/MCM3/CDK7/CDKN2B/STAG1/RBL2/YWHAH/ORC3/E2F4/MCM6/TTK/CDKN2C/E2F5/CDC16/BUB3/CDC20/SMC3/BUB1/CDKN1A/HDAC1/ABL1/CDC25A/MCM5/ORC4/RAD21/TGFB3/CCNE1/CDKN2A/CDK1/ORC5/YWHAZ/CDC7	98
KEGG	hsa00270	Cysteine and methionine metabolism	41/5985	51/8135	0.1719	0.3037	0.2077	MAT2B/BHMT/AGXT2/TST/MDH2/AHCYL1/GCLM/MPST/GOT2/MDH1/IL4I1/PHGDH/ADI1/AHCY/MAT2A/PSAT1/GCLC/APIP/SDS/SDSL/TAT/BCAT2/CDO1/DNMT3B/LACC1/MAT1A/DNMT1/LDHA/ENOPH1/GSS/DNMT3A/BCAT1/LDHB/LDHAL6A/AHCYL2/AMD1/MTAP/MTR/SMS/LDHAL6B/GOT1L1	41
KEGG	hsa04971	Gastric acid secretion	60/5985	76/8135	0.1749	0.306	0.2093	SLC4A2/ATP1B3/CA2/MYLK4/SSTR2/MYLK3/ACTG1/EZR/ITPR2/ADCY6/KCNJ15/KCNJ2/ACTB/PLCB3/ADCY7/CALM2/CALM3/MYLK/CALML5/CALML4/CAMK2G/ATP1B2/CALML3/CALML6/ADCY9/ATP1A3/KCNK10/ADCY8/PRKCA/CALM1/KCNJ1/PRKACA/ATP1A1/HRH2/PLCB4/PRKCG/GNAQ/ATP4B/ITPR3/KCNJ10/KCNK2/ADCY5/MYLK2/CHRM3/GNAI2/KCNQ1/CAMK2D/ATP1A2/PRKACB/PLCB2/SLC9A1/GNAI3/KCNE2/ITPR1/SLC26A7/SST/ADCY3/PLCB1/CAMK2B/PRKACG	60
KEGG	hsa05340	Primary immunodeficiency	31/5985	38/8135	0.175	0.306	0.2093	IL2RG/JAK3/DCLRE1C/CD19/RFXANK/BLNK/AICDA/TAP2/IKBKG/ORAI1/UNG/TAP1/LCK/IGLL1/CD40/BTK/CD40LG/RAG1/CIITA/CD8A/CD79A/IL7R/ADA/AIRE/RFXAP/TNFRSF13B/RAG2/PTPRC/ZAP70/RFX5/LOC102723407	31
KEGG	hsa04926	Relaxin signaling pathway	100/5985	129/8135	0.1782	0.3099	0.212	ATF6B/GNG2/HRAS/SHC1/ATF2/EGFR/KRAS/NFKBIA/GNG11/GNG4/JUN/MMP2/COL1A1/AKT2/ADCY6/RAF1/CREB5/NOS3/MMP9/NRAS/SOS2/PLCB3/ADCY7/GNB2/CREB3L3/MAPK8/GNG5/CREB3/CREB3L4/GNG10/MAP2K4/COL1A2/COL4A1/MAPK9/PIK3CB/GNGT1/NOS1/GNA15/ACTA2/GNG7/ADCY9/PRKCZ/COL4A2/ADCY8/PRKCA/SRC/RLN3/GNG8/PRKACA/TGFBR1/GRB2/AKT3/MMP13/EDNRB/SMAD2/CREB1/PIK3CD/GNG13/PLCB4/NOS2/MAP2K2/TGFBR2/TGFB1/PIK3R3/SHC3/ATF4/GNG3/RLN2/INSL3/FOS/ADCY5/GNAI2/PRKACB/CREB3L1/PLCB2/RXFP1/GNAI3/PIK3R2/ARRB2/VEGFC/MMP1/MAPK1/PIK3CA/AKT1/GNG12/MAPK3/MAPK14/GNAO1/MAP2K1/MAP2K7/MAPK13/SHC2/ADCY3/SOS1/NFKB1/GNB4/ARRB1/PLCB1/PRKACG/VEGFB	100
KEGG	hsa04370	VEGF signaling pathway	47/5985	59/8135	0.1806	0.3126	0.2138	HRAS/MAPKAPK2/KRAS/AKT2/RAF1/PPP3CC/NOS3/NRAS/SPHK1/SPHK2/HSPB1/PTK2/PIK3CB/PLA2G4F/CASP9/PPP3CA/PLA2G4A/RAC1/PRKCA/CDC42/SRC/BAD/AKT3/NFATC2/PIK3CD/RAC3/JMJD7-PLA2G4B/MAP2K2/PIK3R3/PRKCG/PLCG2/RAC2/PPP3CB/PXN/PTGS2/PIK3R2/MAPK1/PIK3CA/AKT1/MAPKAPK3/MAPK3/MAPK14/MAP2K1/SH2D2A/MAPK13/SHC2/PPP3R1	47
KEGG	hsa00310	Lysine degradation	50/5985	63/8135	0.1842	0.3155	0.2157	KMT2D/EHMT1/ALDH9A1/KMT2C/SETD2/ALDH1B1/SMYD2/KMT2B/CAMKMT/PRDM6/PRDM7/PRDM2/DOT1L/AADAT/DHTKD1/ACAT1/EZH1/SUV39H2/EZH2/PRDM16/DLST/SUV39H1/KMT2A/ALDH2/HADH/PLOD1/ECHS1/NSD1/DLD/PLOD2/TMLHE/HYKK/AASS/SETDB1/ALDH3A2/GCDH/ALDH7A1/BBOX1/PLOD3/EHMT2/SMYD1/MECOM/KMT2E/SETD1A/SETDB2/EHHADH/HADHA/SMYD3/SETD7/SETMAR	50
KEGG	hsa03250	Viral life cycle - HIV-1	50/5985	63/8135	0.1842	0.3155	0.2157	AFF4/BICD2/CDK9/SMARCB1/APOBEC3F/FURIN/TSG101/SERINC3/MX2/XPO1/PDCD6IP/RANBP2/CREBBP/MLLT1/APOBEC3D/CCR5/CXCR4/MX1/APOBEC3A/APOBEC3A_B/BST2/VPS4B/PPIA/ELL2/KAT2A/KAT2B/APOBEC3B/CPSF7/MAP1S/SUPT5H/FEZ1/TNPO3/CCNT2/SERINC5/CHMP6/EP300/NELFB/PSIP1/APOBEC3C/MAP1B/CCNT1/BICD1/CPSF6/NELFE/MLLT3/ELL/NUP153/TRIM5/CHMP4A/NELFA	50
KEGG	hsa03013	Nucleocytoplasmic transport	84/5985	108/8135	0.1882	0.3206	0.2193	DDX39B/SAP18/TPR/MAGOH/NUP160/NUP210L/NCBP1/ACIN1/SUMO4/DDX19B/SUMO3/SRRM1/AAAS/RNPS1/CASC3/EIF4A3/RBM8A/XPO6/NUP88/RAE1/PNN/SNUPN/AHCTF1/XPO4/NUP188/POM121/XPO1/NUP50/SEC13/UPF3A/RANBP2/IPO8/KPNB1/NXF1/SENP2/NXF2/NXF2B/RANBP17/POM121C/NUP133/MAGOHB/NCBP2/NUP37/UPF1/NUP155/IPO4/NUP54/KPNA2/UPF3B/NUP85/XPOT/TNPO3/NUP107/TNPO1/THOC6/NMD3/POM121L2/THOC7/NUP62/NXT1/ALYREF/EEF1A2/THOC1/NUP35/XPO5/TMEM33/PHAX/NUP205/IPO5/KPNA3/UBE2I/KPNA4/IPO7/NUP214/NXF3/NUP93/EEF1A1/NUP210/SEH1L/NUP153/KPNA5/IPO9/KPNA6/THOC5	84
KEGG	hsa04130	SNARE interactions in vesicular transport	27/5985	33/8135	0.1918	0.3238	0.2214	VAMP2/STX3/VAMP4/SEC22B/VAMP1/STX1B/VAMP5/VTI1A/YKT6/BET1L/BET1/SNAP23/VAMP7/SNAP29/STX5/STX19/STX16/STX1A/VTI1B/STX6/USE1/STX18/STX11/STX8/STX2/GOSR1/GOSR2	27
KEGG	hsa04918	Thyroid hormone synthesis	59/5985	75/8135	0.1924	0.3238	0.2214	ATF6B/ATF2/TTF1/ATP1B3/GPX1/ITPR2/ADCY6/TPO/CREB5/CGA/GPX2/PLCB3/ADCY7/GPX3/SLC5A5/CREB3L3/DUOX1/CANX/TTR/CREB3/CREB3L4/ATP1B2/ADCY9/ATP1A3/ADCY8/GPX5/ASGR2/PRKCA/HSP90B1/PRKACA/PDIA4/ATP1A1/ASGR1/CREB1/TTF2/SLC26A4/PLCB4/PRKCG/GPX7/ATF4/GNAQ/ITPR3/TSHB/ADCY5/ALB/ATP1A2/PRKACB/CREB3L1/PLCB2/GSR/DUOX2/ITPR1/TSHR/DUOXA2/ADCY3/HSPA5/PLCB1/PRKACG/TG	59
KEGG	hsa04979	Cholesterol metabolism	40/5985	50/8135	0.1929	0.3238	0.2214	NPC1/TSPO/CYP27A1/APOE/CD36/STAR/STARD3/VAPA/APOA4/APOC3/NPC2/SCARB1/APOH/LPA/APOA1/VAPB/LDLR/APOA2/LDLRAP1/ANGPTL3/OSBPL5/LIPA/MYLIP/PLTP/SOAT1/VDAC1/PCSK9/ANGPTL4/LCAT/ABCA1/ABCG8/NCEH1/SORT1/LIPC/ABCB11/LRP1/VDAC2/LIPG/LRPAP1/VDAC3	40
KEGG	hsa03460	Fanconi anemia pathway	43/5985	54/8135	0.1972	0.3268	0.2235	FANCI/EME1/MLH1/ERCC4/EME2/FANCA/PALB2/RMI1/RPA1/BRCA1/RPA2/REV3L/REV1/FANCL/FAN1/FANCB/RMI2/TELO2/TOP3A/RAD51C/RAD51/FANCF/ATRIP/FANCC/WDR48/USP1/POLK/POLN/PMS2/TOP3B/FANCM/POLH/HES1/BRIP1/MUS81/RPA4/FANCD2/BLM/UBE2T/SLX4/SLX1A/SLX1B/ERCC1	43
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	13/5985	15/8135	0.1994	0.3268	0.2235	B4GALNT1/ST3GAL2/ST6GALNAC4/B3GALT4/ST6GALNAC3/ST6GALNAC5/GLB1/HEXB/ST8SIA5/SLC33A1/ST3GAL1/HEXA/ST8SIA1	13
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	20/5985	24/8135	0.1994	0.3268	0.2235	B3GAT3/HS3ST2/B3GALT6/XYLT1/XYLT2/HS3ST3B1/EXTL2/HS2ST1/NDST2/NDST4/B4GALT7/EXTL1/EXT1/NDST1/EXT2/NDST3/GLCE/HS6ST1/HS3ST5/HS3ST1	20
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	30/5985	37/8135	0.1996	0.3268	0.2235	GLS/AGXT2/ABAT/ASRGL1/ASS1/GLS2/ALDH5A1/GOT2/CPS1/IL4I1/GPT2/RIMKLB/GPT/ADSL/RIMKLA/GLUL/GFPT2/AGXT/NAT8L/GLUD2/CAD/ALDH4A1/ASPA/GLUD1/NIT2/GFPT1/DDO/PPAT/GOT1L1/GAD2	30
KEGG	hsa05143	African trypanosomiasis	30/5985	37/8135	0.1996	0.3268	0.2235	HBB/HBA1/HBA2/PLCB3/IDO1/F2RL1/MYD88/FASLG/HPR/APOA1/THOP1/PRKCA/SELE/KNG1/IDO2/IL18/PLCB4/PRKCG/IL10/GNAQ/IFNG/IL1B/TLR9/PLCB2/APOL1/LOC102723407/FAS/IL6/PLCB1/IL12A	30
KEGG	hsa04612	Antigen processing and presentation	61/5985	78/8135	0.2129	0.3469	0.2373	TAPBP/CD74/PSME3/B2M/HLA-C/HLA-G/RFXANK/NFYA/HLA-E/CTSS/HSPA1L/PSME1/NFYB/HSP90AB1/CALR/HSPA1A/HSPA1B/HLA-A/CANX/HLA-B/HSPA6/CTSB/TAP2/HLA-F/HLA-DPA1/IFI30/TAP1/HLA-DMB/NFYC/LGMN/HLA-DRB1/HLA-DQA2/HLA-DRA/HLA-DMA/HSPA4/CREB1/CIITA/HLA-DQB1/CD8A/KLRD1/KLRC1/KLRC2/HLA-DOB/HLA-DRB4/IFNG/HSP90AA1/HLA-DOA/KIR2DS1/RFXAP/PSME2/HLA-DPB1/CTSL/RFX5/KLRC4/KIR2DL5A/HSPA8/HLA-DQA1/KIR2DS3/PDIA3/HSPA5/HSPA2	61
KEGG	hsa04911	Insulin secretion	67/5985	86/8135	0.2158	0.3482	0.2381	VAMP2/ATF6B/ATF2/ATP1B3/ADCYAP1/ADCY6/KCNN1/CREB5/KCNMB2/PLCB3/ADCY7/CREB3L3/ADCYAP1R1/CREB3/KCNMB4/PDX1/CREB3L4/GIP/CAMK2G/ATP1B2/INS/ADCY9/ATP1A3/ADCY8/GNA11/PRKCA/ABCC8/STX1A/PRKACA/ATP1A1/KCNU1/KCNN3/CACNA1F/PCLO/CREB1/PLCB4/RAB3A/PRKCG/ATF4/GNAQ/CACNA1C/ITPR3/KCNMB1/GCG/SNAP25/CACNA1D/KCNN2/CCKAR/ADCY5/GCK/CHRM3/CAMK2D/ATP1A2/SLC2A1/PRKACB/CREB3L1/PLCB2/RYR2/FFAR1/CCK/KCNMB3/GLP1R/RAPGEF4/ADCY3/PLCB1/CAMK2B/PRKACG	67
KEGG	hsa05030	Cocaine addiction	39/5985	49/8135	0.2158	0.3482	0.2381	ATF6B/ATF2/FOSB/JUN/SLC18A2/GPSM1/CREB5/DRD2/GRIN3A/SLC6A3/CREB3L3/CREB3/CREB3L4/PPP1R1B/GRIN2B/CDK5/TH/PRKACA/GRIN1/GRM3/CREB1/GRIN2A/DDC/GRM2/DLG4/ATF4/BDNF/ADCY5/GNAI2/PRKACB/CREB3L1/GNAI3/GRIN2C/GRIA2/GRIN2D/RGS9/DRD1/NFKB1/PRKACG	39
KEGG	hsa04350	TGF-beta signaling pathway	73/5985	94/8135	0.2179	0.3498	0.2393	PPP2R1A/SMURF1/BMP8B/ACVR2A/HAMP/SMAD3/INHBC/SP1/ACVR1/CUL1/RPS6KB2/LTBP1/SMAD4/ID3/NOG/PPP2R1B/ROCK1/RPS6KB1/PPP2CA/CREBBP/RBL1/TFDP1/LEFTY1/ID1/ACVR1C/FMOD/AMH/TGIF1/SMAD6/ZFYVE9/BMP8A/AMHR2/FST/TGFBR1/FBN1/SMAD2/ID4/RHOA/TGFBR2/NBL1/TGIF2/TGFB1/EP300/INHBE/BMP5/NEO1/IFNG/BMP4/INHBA/RGMA/LEFTY2/CDKN2B/SMAD1/E2F4/E2F5/ACVR1B/BMP6/BMPR1B/GDF5/MAPK1/RGMB/CHRD/BAMBI/SMAD5/MAPK3/GREM2/ACVR2B/DCN/ZFYVE16/THBS1/TGFB3/ID2/SMAD7	73
KEGG	hsa00640	Propanoate metabolism	26/5985	32/8135	0.2197	0.3511	0.2401	ECHDC1/ABAT/BCKDHA/ACSS1/ACOX1/ACADS/PCCA/ECHS1/DBT/DLD/ALDH6A1/HIBCH/ACSS3/ACACB/PCCB/SUCLA2/ACSS2/MLYCD/SUCLG2/LDHA/ACACA/LDHB/LDHAL6A/EHHADH/HADHA/LDHAL6B	26
KEGG	hsa04936	Alcoholic liver disease	109/5985	142/8135	0.2214	0.3521	0.2408	CPT1A/IFNA10/IFNA16/ALDH9A1/NFKBIA/IFNA14/ADIPOR1/TRA2B/ALDH1B1/TRADD/AKT2/IFNA17/TRA2A/TRAF6/GSK3B/FADD/IRAK4/MAP3K5/IFNA13/C4A/C4B/IRF3/CD14/MYD88/PRKAG3/MAPK8/LPIN2/TAB1/MAP3K7/MAP2K3/PPARGC1A/TNFRSF1A/IL17RA/IFNA4/ADH1B/ACOX1/ACADM/CPT1B/MAP2K4/CHUK/MAPK9/IFNA7/IKBKG/FASLG/TAB3/ALDH2/CTNNB1/ADIPOR2/CPT1C/TLR4/FASN/TCF7L1/ADH4/C5AR1/AKT3/NOX4/ACACB/SIRT1/IFNA1/ADH5/CXCL1/ALDH3A2/IKBKE/CXCL2/MLYCD/TIRAP/ADH7/IFNA5/PRKAG1/ALDH7A1/CXCL3/ACADVL/IL17A/IL1B/TICAM1/SREBF1/IL17RC/IFNA8/PRKAB1/LY96/IFNA6/TRAF3/FOXO1/FABP1/C1QC/LBP/ACACA/IFNA21/C3AR1/TAB2/C2/ADH1A/IFNA2/CXCL8/ADH6/AKT1/IRAK1/C5/MAPK14/PRKAA1/CYP2E1/MAP2K7/MAPK13/FAS/FOXO3/NFKB1/IL6/ADH1C/IL12A	109
KEGG	hsa03060	Protein export	19/5985	23/8135	0.233	0.367	0.251	SPCS3/SRP19/SRP14/SEC61A2/SPCS2/SEC61G/SRP68/SPCS1/SEC62/SEC11C/IMMP1L/SEC61A1/SRP9/OXA1L/SRP54/SEC61B/SRPRB/SRP72/HSPA5	19
KEGG	hsa03430	Mismatch repair	19/5985	23/8135	0.233	0.367	0.251	MLH1/MSH6/RFC3/POLD1/RPA1/RPA2/PCNA/POLD4/RFC1/RFC2/MLH3/SSBP1/RFC4/PMS2/POLD3/RPA4/RFC5/EXO1/POLD2	19
KEGG	hsa04066	HIF-1 signaling pathway	84/5985	109/8135	0.2373	0.3721	0.2545	EGFR/MKNK1/ARNT/AKT2/EGF/ANGPT2/CDKN1B/NOS3/MKNK2/RPS6KB2/EIF4E/IL6R/PDHA1/HK1/MTOR/TEK/TFRC/IFNGR2/RPS6KB1/CREBBP/ENO3/PDK1/ANGPT1/IGF1R/PIK3CB/IFNGR1/CUL2/HK3/GAPDH/CAMK2G/EGLN3/ALDOA/ERBB2/TIMP1/INS/PFKFB3/TLR4/FLT1/PRKCA/HIF1A/AKT3/EIF4EBP1/ENO1/EPO/PGK1/PFKM/PIK3CD/BCL2/NOS2/ANGPT4/MAP2K2/ALDOC/EP300/PIK3R3/PRKCG/PGK2/PLCG2/IFNG/LDHA/EGLN2/ENO2/CAMK2D/SLC2A1/PIK3R2/STAT3/TF/HMOX1/LDHB/LDHAL6A/MAPK1/PIK3CA/AKT1/SERPINE1/CDKN1A/MAPK3/PDHA2/MAP2K1/HK2/VHL/NFKB1/PFKP/LDHAL6B/IL6/CAMK2B	84
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	12/5985	14/8135	0.2417	0.3772	0.258	B4GALT1/CHST1/ST3GAL2/B4GALT4/CHST4/B3GNT7/B4GALT3/ST3GAL1/CHST6/B4GALT2/ST3GAL3/B3GNT2	12
KEGG	hsa00830	Retinol metabolism	53/5985	68/8135	0.2512	0.3903	0.2669	CYP2A7/UGT1A10/UGT1A4/UGT1A6/CYP3A5/UGT1A1/DHRS9/RETSAT/UGT1A8/UGT1A9/RDH13/CYP1A1/UGT2B15/CYP2C18/CYP2B6/RDH11/DHRS4/DHRS4L2/CYP2C9/RDH16/AOX1/ALDH1A1/CYP3A7/ADH1B/PNPLA4/ADH4/CYP2W1/RDH12/RDH5/CYP26A1/ADH5/CYP26B1/DGAT1/UGT1A3/UGT1A5/ADH7/ALDH1A2/UGT2A3/CYP2A6/RDH10/CYP1A2/SDR16C5/UGT1A7/RDH8/ALDH1A3/DHRS3/CYP2C8/ADH1A/ADH6/UGT2A1/UGT2A2/CYP2S1/ADH1C	53
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	77/5985	100/8135	0.2552	0.3946	0.2699	HRAS/KRAS/JUN/MMP2/COL1A1/SMAD3/AKT2/CDKN1B/NOS3/NRAS/SMAD4/DIAPH1/PLCB3/MAPK8/STAT5B/NOX1/COL1A2/COL4A1/MAPK9/PIK3CB/THBD/EGR1/PRKCZ/RAC1/AGER/COL4A2/PRKCA/CDC42/PRKCD/SELE/BAX/TGFBR1/PLCD4/AKT3/NOX4/CDK4/SMAD2/PLCE1/STAT5A/PIK3CD/PLCB4/PLCD3/BCL2/PIM1/CCL2/TGFBR2/TGFB1/PIK3R3/STAT1/PLCG2/AGT/F3/IL1B/AGTR1/FOXO1/FN1/PLCB2/PIK3R2/STAT3/VEGFC/JAK2/CXCL8/MAPK1/PIK3CA/AKT1/SERPINE1/MAPK3/MAPK14/PRKCE/IL1A/TGFB3/MAPK13/NFKB1/IL6/PLCB1/VEGFB/PLCD1	77
KEGG	hsa00511	Other glycan degradation	15/5985	18/8135	0.2591	0.3988	0.2727	GBA/NEU1/MAN2C1/GLB1/MAN2B2/HEXB/NEU2/MANBA/NEU3/MAN2B1/GBA2/AGA/NEU4/HEXA/FUCA2	15
KEGG	hsa00220	Arginine biosynthesis	18/5985	22/8135	0.2706	0.4146	0.2836	GLS/ARG2/ARG1/NOS3/ASS1/GLS2/GOT2/NOS1/CPS1/GPT2/GPT/GLUL/NOS2/NAGS/OTC/GLUD2/GLUD1/GOT1L1	18
KEGG	hsa04360	Axon guidance	138/5985	182/8135	0.2729	0.4152	0.284	CFL1/HRAS/PTPN11/MYL12A/EFNB3/KRAS/ITGB1/SMO/GSK3B/SEMA5B/RAF1/PPP3CC/RASA1/NFATC4/EPHA8/EFNA1/EPHB1/NRAS/PLXNA3/L1CAM/PDPK1/ABLIM3/FES/PAK4/ROCK1/NTN3/LIMK1/ARHGEF12/CFL2/EPHB3/CXCR4/PTK2/ROCK2/PIK3CB/SHH/RGS3/CAMK2G/PARD3/PPP3CA/CXCL12/PAK2/SEMA3B/TRPC5/SEMA4F/LRRC4/PRKCZ/RAC1/CDK5/PAK1/NTN1/PRKCA/CDC42/PARD6B/MET/SRC/SEMA6B/SEMA6C/LRIG2/NTNG1/SEMA4A/FZD3/SEMA5A/PLXNA2/EPHA6/NTNG2/PARD6A/SEMA6D/NFATC2/EPHB6/PARD6G/PIK3CD/RHOD/RHOA/RAC3/BOC/SEMA4G/PAK3/LRRC4C/WNT5A/DCC/PIK3R3/SEMA3F/UNC5B/MYL9/SEMA3C/SSH2/PLXNA4/TRPC6/EFNA3/NRP1/PLCG2/EPHA2/NEO1/LIMK2/PLXNB1/DPYSL2/RAC2/PPP3CB/FYN/SEMA4B/RGMA/RYK/PLXNB2/UNC5C/SSH1/PLXNB3/TRPC1/GNAI2/CAMK2D/GNAI3/PIK3R2/BMPR1B/NTN4/MYL5/EPHA7/MYL12B/SLIT1/MAPK1/PIK3CA/SSH3/SEMA3D/MAPK3/ABL1/PTCH1/ABLIM1/ENAH/WNT5B/SRGAP2/ABLIM2/PAK6/WNT4/PPP3R1/SEMA7A/SLIT2/EFNB2/CAMK2B/DPYSL5/EFNA4	138
KEGG	hsa05217	Basal cell carcinoma	49/5985	63/8135	0.2735	0.4152	0.284	TP53/DVL3/FZD2/WNT2/SMO/GSK3B/WNT8A/WNT1/SHH/GADD45A/WNT2B/SUFU/CTNNB1/AXIN1/APC/APC2/WNT9B/TCF7L1/KIF7/BAX/FZD3/FZD7/WNT3/FZD10/FZD6/WNT5A/POLK/FZD4/GADD45B/FZD8/GLI3/HHIP/GLI1/WNT11/DDB2/BMP4/WNT9A/WNT7B/WNT8B/CDKN1A/PTCH2/AXIN2/WNT7A/PTCH1/WNT5B/BAK1/WNT4/DVL1/WNT10A	49
KEGG	hsa01230	Biosynthesis of amino acids	58/5985	75/8135	0.2751	0.4158	0.2843	MAT2B/ARG2/PGAM2/RPEL1/TALDO1/IDH1/CS/ARG1/PGAM1/ASS1/PKM/RPE/GOT2/ENO3/PAH/TPI1/GAPDH/CPS1/ALDOA/GPT2/PHGDH/TKT/MAT2A/GPT/ACO2/PSAT1/SHMT1/TKTL2/ENO1/ACO1/PGK1/ALDH18A1/PFKM/SDS/PC/GLUL/SDSL/NAGS/IDH3B/IDH2/ALDOC/OTC/PGK2/PRPS2/BCAT2/IDH3G/MAT1A/RPIA/PYCR2/TKTL1/ENO2/PKLR/BCAT1/PRPS1/MTR/SHMT2/PFKP/GOT1L1	58
KEGG	hsa04950	Maturity onset diabetes of the young	21/5985	26/8135	0.2787	0.4193	0.2867	NEUROD1/NKX6-1/HHEX/PDX1/NEUROG3/INS/MNX1/RFX6/PAX4/HNF1B/ONECUT1/NR5A2/FOXA3/IAPP/HNF4G/PKLR/HES1/GCK/HNF1A/HNF4A/PAX6	21
KEGG	hsa00020	Citrate cycle (TCA cycle)	24/5985	30/8135	0.2845	0.4223	0.2888	SDHC/SDHD/IDH1/CS/MDH2/ACLY/PDHA1/FH/DLST/MDH1/OGDHL/ACO2/DLD/SDHB/ACO1/PC/IDH3B/SUCLA2/IDH2/SUCLG2/IDH3G/PCK2/PDHA2/DLAT	24
KEGG	hsa00030	Pentose phosphate pathway	24/5985	30/8135	0.2845	0.4223	0.2888	GLYCTK/RPEL1/TALDO1/PGM1/G6PD/RPE/PGLS/ALDOA/TKT/FBP1/TKTL2/PFKM/DERA/PGM2/ALDOC/PRPS2/RGN/RPIA/TKTL1/GPI/FBP2/IDNK/PRPS1/PFKP	24
KEGG	hsa00053	Ascorbate and aldarate metabolism	24/5985	30/8135	0.2845	0.4223	0.2888	ALDH9A1/UGT1A10/UGT1A4/ALDH1B1/UGT1A6/UGT1A1/UGT1A8/UGT1A9/MIOX/GUSB/UGT2B15/ALDH2/UGDH/AKR1A1/ALDH3A2/UGT1A3/UGT1A5/UGT2A3/KL/ALDH7A1/RGN/UGT1A7/UGT2A1/UGT2A2	24
KEGG	hsa05332	Graft-versus-host disease	33/5985	42/8135	0.2941	0.4347	0.2973	HLA-C/HLA-G/HLA-E/HLA-A/HLA-B/HLA-F/CD80/HLA-DPA1/FASLG/HLA-DMB/GZMB/HLA-DRB1/HLA-DQA2/HLA-DRA/CD86/HLA-DMA/HLA-DQB1/IL2/KLRD1/KLRC1/HLA-DOB/HLA-DRB4/IFNG/IL1B/HLA-DOA/PRF1/HLA-DPB1/KIR2DL5A/HLA-DQA1/IL1A/FAS/CD28/IL6	33
KEGG	hsa04390	Hippo signaling pathway	119/5985	157/8135	0.2956	0.4349	0.2974	YWHAE/PPP2R1A/LATS1/NF2/DVL3/MPP5/FZD2/LLGL1/BMP8B/DLG1/SMAD3/PPP1CC/PPP2R2D/WNT2/FBXW11/YWHAB/ACTG1/GSK3B/YWHAG/AREG/PPP1CB/ACTB/SMAD4/NKD2/WNT8A/PPP2R1B/CCND2/PPP2CA/WNT1/ID1/WNT2B/LLGL2/PARD3/CTNNA3/CTNNB1/AXIN1/APC/AMH/PRKCZ/TEAD2/APC2/WNT9B/AMOT/WWTR1/TCF7L1/PARD6B/TEAD4/WWC1/SOX2/BMP8A/TGFBR1/FRMD1/FZD3/FZD7/PARD6A/AJUBA/SMAD2/WNT3/FGF1/PARD6G/FZD10/FZD6/FRMD6/CRB2/TGFBR2/WNT5A/BTRC/TGFB1/PPP2R2C/FZD4/DLG4/FZD8/BMP5/CRB1/SAV1/CDH1/ITGB2/YWHAQ/TP73/WNT11/BMP4/PPP2R2A/SCRIB/PPP1CA/LATS2/YAP1/WNT9A/AFP/SMAD1/YWHAH/WNT7B/CTNNA1/MOB1A/TEAD1/WNT8B/BMP6/BMPR1B/GDF5/SERPINE1/PRKCI/AXIN2/STK3/WNT7A/LIMD1/TEAD3/WNT5B/WTIP/TGFB3/WNT4/DVL1/TP53BP2/BIRC5/ID2/DLG3/SMAD7/YWHAZ/WNT10A/SNAI2/BIRC3	119
KEGG	hsa01240	Biosynthesis of cofactors	116/5985	153/8135	0.2969	0.4349	0.2974	PANK2/MAT2B/AK8/PTS/ALAS2/NADSYN1/UGT1A10/UGT1A4/NADK2/ALDH1B1/AK9/UGT1A6/SPR/FPGS/NME6/UGP2/GMPPA/HMBS/VKORC1/ALPP/UGT1A1/AK7/NMNAT3/UGT1A8/UGT1A9/NME7/NMNAT1/RDH13/CPOX/GCLM/ALAS1/EARS2/GUSB/UGT2B15/IDO1/MTHFD2/AK6/AK4/RDH11/PPCDC/COQ5/COQ6/COX10/MOCS2/UROD/ALPI/AK3/ALDH2/FECH/NME3/MAT2A/ADSL/UGDH/PSAT1/GMPPB/SHMT1/PMM1/PPCS/RDH12/DLD/OXSM/NMNAT2/GCLC/UROS/GGH/KMO/IDO2/AKR1A1/HPD/ASPDH/NADK/PDXP/DHODH/CMPK1/NQO1/KYNU/GGCX/MMAB/ALDH3A2/TDO2/UGT1A3/UGT1A5/PNPO/UGT2A3/ALPL/BCAT2/AK2/RGN/MAT1A/SDR16C5/UGT1A7/RFK/PMM2/COQ3/LIPT1/GSS/DHRS3/COASY/VKORC1L1/BCAT1/NFS1/MTHFD1L/UMPS/CAD/CMPK2/UGT2A1/UGT2A2/LIAS/COX15/FLAD1/SHMT2/MOCS1/QPRT/PANK1/NME4/PHOSPHO2	116
KEGG	hsa04514	Cell adhesion molecules	113/5985	149/8135	0.2982	0.435	0.2975	CD276/CLDN7/ITGB1/CLDN17/SPN/HLA-C/HLA-G/CLDN15/ITGA4/SELP/SELL/CLDN3/ICAM3/CLDN20/CLDN19/HLA-E/ICAM2/L1CAM/F11R/MADCAM1/HLA-A/CLDN8/ITGA9/HLA-B/LRRC4B/HLA-F/CD34/JAM3/CD80/HLA-DPA1/CLDN5/SDC4/PTPRF/SDC3/VCAN/CLDN1/MPZL1/LRRC4/NLGN4X/CLDN4/MAG/NRXN2/HLA-DMB/ESAM/SELE/NTNG1/HLA-DRB1/CD40/CD6/HLA-DQA2/NRXN3/NTNG2/HLA-DRA/CD86/SELPLG/HLA-DMA/CDH15/CLDN14/CD2/CD40LG/CDH5/CLDN16/SIGLEC1/CADM1/CD274/ITGAL/ALCAM/HLA-DQB1/CD8A/LRRC4C/CDH3/NRXN1/CLDN11/CDH1/CLDN10/ITGAM/ITGB2/HLA-DOB/HLA-DRB4/NEO1/CNTNAP1/CDH2/CNTN2/HLA-DOA/CD99L2/CTLA4/VTCN1/OCLN/NFASC/CLDN18/SDC2/PECAM1/CADM3/CD226/CNTNAP2/MPZ/HLA-DPB1/PTPRC/TIGIT/CD99/GLG1/PVR/CD22/CLDN23/NLGN4Y/HLA-DQA1/CNTN1/PDCD1/CD28/ITGA8/ITGA6/CDH4/CLDN9	113
KEGG	hsa00120	Primary bile acid biosynthesis	14/5985	17/8135	0.3043	0.4418	0.3022	BAAT/CYP46A1/CYP27A1/CYP8B1/ACOT8/SCP2/HSD3B7/SLC27A5/AKR1D1/CYP39A1/AKR1C4/CH25H/AMACR/HSD17B4	14
KEGG	hsa04970	Salivary secretion	71/5985	93/8135	0.3165	0.4574	0.3128	VAMP2/DMBT1/SLC4A2/ATP1B3/MUC5B/ADRA1B/ITPR2/ADCY6/PRH2/PLCB3/ADCY7/BEST2/PRKG1/CAMP/CALM2/CALM3/AQP5/BST1/CST4/CALML5/CALML4/NOS1/LYZ/ATP1B2/CALML3/CALML6/ADCY9/ATP1A3/ADCY8/PRKCA/CALM1/ADRA1D/RYR3/PRKACA/ATP1A1/PRB1/SLC12A2/GUCY1A2/PLCB4/CD38/CST3/ATP2B3/PRKCG/GNAQ/ATP2B4/STATH/ATP2B2/ITPR3/AMY1A/AMY1B/AMY1C/AMY2A/ADCY5/ATP2B1/CHRM3/MUC7/ADRB2/ATP1A2/PRKACB/PLCB2/SLC9A1/AMY2B/LYZL1/PRH1/ITPR1/ADRB1/HTN1/CST1/ADCY3/PLCB1/PRKACG	71
KEGG	hsa04392	Hippo signaling pathway - multiple species	23/5985	29/8135	0.3213	0.4574	0.3128	LATS1/NF2/RASSF2/TEAD2/WWTR1/PAK1/TEAD4/WWC1/FAT4/FRMD1/AJUBA/FRMD6/RASSF4/SAV1/LATS2/YAP1/MOB1A/TEAD1/STK3/LIMD1/TEAD3/DCHS2/WTIP	23
KEGG	hsa04115	p53 signaling pathway	56/5985	73/8135	0.3222	0.4574	0.3128	TP53/MDM4/MDM2/CDK6/SESN3/CD82/EI24/RCHY1/TNFRSF10B/CCND2/CCNG1/RRM2B/CCNE2/SESN1/SIVA1/BID/GADD45A/ZMAT3/CASP9/SIAH1/PPM1D/PMAIP1/BAX/APAF1/TSC2/PIDD1/ATM/CDK4/CCNG2/CCNB1/BCL2/CHEK1/CCNB2/CDK2/TP53I3/PTEN/GADD45B/TP73/SFN/DDB2/IGFBP3/GTSE1/SESN2/SERPINB5/STEAP3/SERPINE1/CDKN1A/THBS1/TNFRSF10A/CCNE1/FAS/CDKN2A/GORAB/RRM2/CDK1/BCL2L1	56
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	53/5985	69/8135	0.3232	0.4574	0.3128	CYP2A7/UGT1A10/UGT1A4/UGT1A6/GSTA3/NAT2/CYP3A5/GSTM5/UGT1A1/UGT1A8/UGT1A9/MGST1/CYP1A1/EPHX1/UGT2B15/CYP1B1/CYP2C18/CYP2C9/CYP3A7/GSTA4/CBR1/HSD11B1/SULT1A1/NAT1/GSTO1/GSTM3/MGST2/SULT1A2/SULT1A3/SULT1A4/GSTM2/UGT1A3/UGT1A5/SULT2A1/UGT2A3/CYP2A6/AKR1C2/CYP1A2/UGT1A7/GSTA1/CYP3A43/GSTM1/PTGS2/CYP2A13/CYP2C8/GSTM4/CYP2C19/UGT2A1/UGT2A2/GSTK1/CYP2E1/GSTP1/GSTT2	53
KEGG	hsa04310	Wnt signaling pathway	126/5985	167/8135	0.3239	0.4574	0.3128	TP53/DVL3/FZD2/PSEN1/JUN/PPARD/PRICKLE3/SMAD3/WNT2/FBXW11/GSK3B/FRAT2/PPP3CC/NFATC4/FRAT1/CUL1/RNF43/SMAD4/PLCB3/CSNK2A1/TLE4/CTNNBIP1/NKD2/CSNK2B/WNT8A/TLE6/CHD8/LGR5/MAPK8/CTBP2/CCND2/DKK1/PORCN/MAP3K7/CREBBP/ZNRF3/WNT1/INVS/MAPK9/ROCK2/CXXC4/SENP2/WNT2B/CAMK2G/PPP3CA/CTNNB1/SIAH1/CTNND2/RSPO3/AXIN1/ROR1/APC/RAC1/APC2/WNT9B/TCF7L1/PRKCA/PRKACA/SFRP2/MMP7/FZD3/FZD7/LGR4/WNT3/NFATC2/FZD10/PLCB4/FZD6/RHOA/RAC3/WNT5A/BTRC/EP300/PRKCG/FZD4/PRICKLE2/PRICKLE4/FZD8/CBY1/VANGL2/CSNK1A1/GPC4/RSPO2/DKK4/LRP6/RUVBL1/WNT11/SFRP4/FOSL1/RAC2/TLE3/PPP3CB/RYK/RSPO1/DAAM2/DAAM1/WNT9A/SERPINF1/WNT7B/NLK/CAMK2D/PRKACB/PLCB2/WNT8B/CTBP1/TBL1XR1/TLE2/BAMBI/AXIN2/WNT7A/CER1/DKK2/CSNK2A2/WNT5B/TBL1X/LRP5/WNT4/DVL1/PPP3R1/CACYBP/PLCB1/CAMK2B/PRKACG/SOST/SFRP1/WNT10A	126
KEGG	hsa00590	Arachidonic acid metabolism	47/5985	61/8135	0.3248	0.4574	0.3128	PTGES2/GPX1/CYP4F3/PTGES3/GPX2/GPX3/TBXAS1/PTGS1/ALOX12/CYP2B6/CYP4F2/CYP2C9/CYP4F8/PLA2G2D/CBR1/PLA2G1B/PLA2G4F/LTA4H/PLA2G2F/CYP2J2/PLA2G2A/PLA2G4A/PLA2G12A/GPX5/EPHX2/ALOX15B/ALOX5/GGT5/JMJD7-PLA2G4B/GPX7/PTGDS/AKR1C3/PLA2G2E/PLA2G12B/CYP2U1/ALOX15/PLA2G3/PTGS2/LTC4S/CYP2C8/PLA2G10/PLA2G6/CYP2C19/CYP2E1/PLA2G5/GGT1/PLB1	47
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	29/5985	37/8135	0.325	0.4574	0.3128	KRAS/ATP1B3/PDPK1/SLC9A3R2/NEDD4L/IRS1/PIK3CB/ATP1B2/SCNN1G/INS/ATP1A3/SCNN1A/PRKCA/KCNJ1/ATP1A1/HSD11B2/FXYD4/PIK3CD/NR3C2/PIK3R3/PRKCG/SFN/ATP1A2/PIK3R2/MAPK1/PIK3CA/MAPK3/SGK1/SCNN1B	29
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	41/5985	53/8135	0.3259	0.4574	0.3128	ATP1B3/CLTC/SLC8A3/ADCY6/CLTA/PLCB3/DNM2/AP2A2/AP2B1/ATP1B2/ADCY9/ATP1A3/AP2S1/PRKCA/AP2A1/PRKACA/KLK2/SLC8A2/ATP1A1/VDR/TRPV5/ESR1/PLCB4/KLK1/PTH1R/ATP2B3/PRKCG/KL/GNAQ/ATP2B4/ATP2B2/CALB1/ATP2B1/DNM3/ATP1A2/PRKACB/PLCB2/RAB11A/CLTCL1/PLCB1/PRKACG	41
KEGG	hsa04714	Thermogenesis	174/5985	232/8135	0.3387	0.4734	0.3237	ARID1A/HRAS/SDHC/ND3/CPT1A/ATF2/COX7B/ND6/KRAS/NDUFAF5/BMP8B/NDUFA10/COX6C/UQCRB/CPT2/COX7C/SDHD/SMARCB1/RHEB/NDUFA1/ACTL6A/COX14/SMARCA2/ND2/ACTG1/ARID1B/NDUFB7/NDUFB6/ADCY6/NPPB/NDUFAF3/CREB5/ACSL1/COX3/ACTB/SMARCD1/KLB/KDM3B/UQCRH/UQCRHL/COX4I1/NRAS/NDUFS5/RPS6KB2/FRS2/SOS2/COA3/ADCY7/MAP3K5/PRKG1/COX1/MTOR/UQCR10/CREB3L3/NDUFAF1/NDUFA4/NDUFS7/COX2/NDUFA3/PRKAG3/PNPLA2/NDUFA11/NDUFA6/RPS6KB1/CREB3/COX8A/PRDM16/MAP2K3/PPARGC1A/NDUFV1/CREB3L4/ZNF516/CPT1B/COX10/MGLL/NDUFA8/TSC1/ATP6/NDUFA2/ACTL6B/COX5B/COX6B2/COX11/PLIN1/UQCRQ/COX6A1/NDUFA13/CYC1/RPS6KA1/NDUFB1/CPT1C/ADCY9/RPS6KA3/NDUFA7/COX17/ADCY8/COX7A1/SLC25A20/PRKACA/BMP8A/UQCRFS1/NDUFB2/ACSL6/FGFR1/RPTOR/TSC2/NPR1/NDUFB10/SDHB/NDUFS6/GRB2/NDUFS3/ND4/NDUFV3/NDUFAF2/ACSL4/CREB1/DPF1/UQCRC1/AKT1S1/KDM1A/ACSL3/NDUFA9/COX20/NDUFS4/DPF3/PRKAG1/RPS6KA6/NDUFB5/UQCRC2/COA4/PPARG/NDUFA4L2/FGF21/COX16/GCG/COX7A2L/PRKAB1/UQCR11/SMARCD2/NDUFB9/ADCY5/NDUFAF6/COA6/NDUFV2/NDUFB8/LIPE/PRKACB/CREB3L1/NDUFS1/SMARCC1/KDM3A/NDUFS2/NDUFB4/COX6B1/SMARCA4/CNR1/COA7/COA1/RPS6KA2/MAPK14/PRKAA1/COX15/NDUFB3/COX5A/SIRT6/COX19/MAPK13/ADCY3/SOS1/NDUFAB1/MLST8/COX8C/PRKACG	174
KEGG	hsa04512	ECM-receptor interaction	67/5985	88/8135	0.3404	0.4737	0.324	DSPP/LAMB1/FRAS1/ITGB1/COL1A1/TNN/ITGB5/ITGA4/VWF/COMP/CD36/ITGB3/ITGA10/CD44/GP1BB/COL6A3/SV2C/ITGA9/ITGA5/GP9/DMP1/COL2A1/COL1A2/ITGB4/COL4A1/ITGA11/COL6A1/RELN/SDC4/HSPG2/VTN/AGRN/LAMC1/ITGA2B/COL4A2/GP5/CD47/ITGB6/CHAD/THBS4/THBS2/LAMB2/TNR/SV2A/FREM2/SV2B/GP6/LAMB3/LAMA2/GP1BA/HMMR/COL6A2/IBSP/DAG1/FN1/LAMA5/ITGA1/COL9A2/ITGA2/THBS3/SPP1/THBS1/LAMC2/LAMC3/ITGA3/ITGA8/ITGA6	67
KEGG	hsa05133	Pertussis	58/5985	76/8135	0.3456	0.479	0.3276	CFL1/CXCL5/JUN/ITGB1/TRAF6/IRF1/IRAK4/PYCARD/C4A/C4B/TICAM2/IRF3/CD14/MYD88/CALM2/CALM3/MAPK8/ITGA5/CFL2/CALML5/CALML4/MAPK9/IRF8/CALML3/SERPING1/CALML6/TLR4/CALM1/C4BPA/CASP1/NOS2/RHOA/IL10/TIRAP/ITGAM/ITGB2/IL23A/IL1B/TICAM1/FOS/LY96/NOD1/GNAI2/C1QC/GNAI3/C2/CXCL8/MAPK1/IRAK1/C5/MAPK3/MAPK14/CXCL6/IL1A/MAPK13/NFKB1/IL6/IL12A	58
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	159/5985	212/8135	0.3486	0.4811	0.329	ATF6B/RXRB/HRAS/ATF2/EGFR/KRAS/UGT1A10/UGT1A4/JUN/ARNT/UGT1A6/MIR29A/MIR29B1/AKT2/GSTA3/EGF/ADCY6/FGF8/GSTM5/UGT1A1/RAF1/CREB5/UGT1A8/UGT1A9/PAQR8/MGST1/NRAS/XIAP/PTGES3/CYP1A1/RPS6KB2/SOS2/EPHX1/AIPL1/ADCY7/FGF3/UGT2B15/CYP1B1/MTOR/ESR2/CREB3L3/HSP90AB1/FGF4/CYP2B6/AR/PAQR7/RPS6KB1/CREB3/STAT5B/RXRA/KPNB1/CREB3L4/WNT1/BCL6/GSTA4/PIK3CB/FGF16/CHRNB4/RPS6KA1/DLL1/MIR29B2/MIR29C/ADCY9/RPS6KA3/ADCY8/PRKCA/EPHX2/GSTO1/GSTM3/CHRNA4/HSP90B1/FGF9/SRC/CHRNA9/FGF18/FGF20/PRKACA/NR1I3/MGST2/KPNA2/BAD/GRB2/AKT3/CHRNB2/EIF4EBP1/CACNA1F/VDR/CACNA1A/CREB1/RB1/STAT5A/AIP/PIK3CD/ESR1/FGF2/BCL2/FGF22/GSTM2/MAP2K2/IKBKE/PIK3R3/PRKCG/UGT1A3/UGT1A5/UGT2A3/PGR/RPS6KA6/ATF4/CYP1A2/CHRNA3/CACNA1C/HSP90AA1/UGT1A7/AHR/FOS/EPHX3/CACNA1D/GSTA1/PAQR5/NOTCH2/ADCY5/GSTM1/GNAI2/ADRB2/PRKACB/CREB3L1/GNAI3/PIK3R2/STAT3/FGF17/ARRB2/DLL4/JAK2/GSTM4/KPNA3/MAPK1/PIK3CA/AKT1/KPNA4/UGT2A1/UGT2A2/ADRB1/MAPK3/DLL3/CDC25A/FGF5/RPS6KA2/TNFSF11/MAP2K1/KPNA5/ADCY3/GSTT2/BIRC5/SOS1/NFKB1/ARRB1/KPNA6/KLF4/PRKACG	159
KEGG	hsa04978	Mineral absorption	46/5985	60/8135	0.3524	0.4843	0.3312	SLC40A1/ATP1B3/SLC8A3/SLC9A3/MT1M/HMOX2/SLC31A1/FTL/ATP7B/SLC34A3/CYBRD1/TRPM6/MT1HL1/ATP1B2/MT1G/MT1H/ATP1A3/SLC8A2/SLC6A19/ATP1A1/TRPM7/SLC34A2/SLC26A9/MT1E/CLCN2/VDR/MT1F/SLC11A2/MT1X/SLC5A1/ATP2B3/SLC26A6/MT2A/STEAP2/SLC34A1/SLC30A1/ATP2B4/ATP2B2/SLC46A1/ATP2B1/ATP1A2/ATP7A/TF/HMOX1/SLC39A4/FTH1	46
KEGG	hsa00600	Sphingolipid metabolism	40/5985	52/8135	0.3555	0.4866	0.3328	CERS5/CERS2/DEGS1/ENPP7/CERS3/B4GALNT1/DEGS2/CERK/SPHK1/CERS1/SPHK2/SGMS1/PSAPL1/GBA/PSAP/GLA/ACER3/KDSR/NEU1/B4GALT6/SMPD1/ASAH1/GLB1/HEXB/SGPP2/SGMS2/NEU2/UGT8/SPTLC2/SPTLC1/SMPD4/NEU3/CERS4/SMPD2/GAL3ST1/GBA2/GALC/UGCG/NEU4/HEXA	40
KEGG	hsa03030	DNA replication	28/5985	36/8135	0.3603	0.4901	0.3352	RFC3/MCM4/POLD1/RPA1/RPA2/PRIM2/PCNA/POLD4/RFC1/RNASEH2B/POLE3/RFC2/SSBP1/RFC4/RNASEH1/POLE4/RNASEH2A/MCM7/POLE/MCM3/POLD3/MCM6/RNASEH2C/DNA2/RPA4/RFC5/MCM5/POLD2	28
KEGG	hsa00650	Butanoate metabolism	22/5985	28/8135	0.361	0.4901	0.3352	HMGCS1/ABAT/HMGCL/ACAT1/L2HGDH/AACS/ALDH5A1/OXCT2/ACADS/HADH/ACSM5/ECHS1/OXCT1/BDH1/HMGCLL1/EHHADH/HADHA/BDH2/ACSM1/ACSM2B/ACSM2A/GAD2	22
KEGG	hsa04723	Retrograde endocannabinoid signaling	111/5985	148/8135	0.3857	0.5179	0.3542	GNG2/ND3/GABRG2/ND6/NDUFA10/GNG11/GNG4/NDUFA1/ND2/NDUFB7/NDUFB6/ITPR2/ADCY6/NDUFS5/GABRA4/PLCB3/ADCY7/GRM1/GNB2/NDUFA4/NDUFS7/NDUFA3/NDUFA11/MAPK8/NDUFA6/GNG5/KCNJ6/NDUFV1/GNG10/GABRB3/MGLL/MAPK9/NDUFA8/KCNJ9/GNGT1/NDUFA2/SLC17A7/NAPEPLD/RIMS1/NDUFA13/NDUFB1/GNG7/ADCY9/NDUFA7/ADCY8/PRKCA/GNG8/PRKACA/NDUFB2/NDUFB10/GABRE/NDUFS6/NDUFS3/ND4/NDUFV3/CACNA1F/CACNA1A/SLC32A1/GABRB2/GNG13/PLCB4/GABRP/KCNJ3/GABRQ/PRKCG/NDUFA9/NDUFS4/SLC17A8/GABRR1/NDUFB5/GNAQ/GRM5/GNG3/CACNA1C/NDUFA4L2/ITPR3/CACNA1D/GABRR2/NDUFB9/FAAH/ADCY5/NDUFV2/DAGLA/NDUFB8/PTGS2/GNAI2/GRIA4/PRKACB/PLCB2/NDUFS1/GNAI3/SLC17A6/GABRD/NDUFS2/NDUFB4/GRIA2/ITPR1/GABRA3/MAPK1/CNR1/GNG12/MAPK3/MAPK14/GNAO1/NDUFB3/MAPK13/ADCY3/GNB4/NDUFAB1/PLCB1/PRKACG	111
KEGG	hsa00330	Arginine and proline metabolism	39/5985	51/8135	0.3865	0.5179	0.3542	ARG2/ALDH9A1/ALDH1B1/LOC102724788/PRODH/ARG1/NOS3/DAO/HOGA1/OAT/L3HYPDH/P4HA1/GOT2/NOS1/ALDH2/CNDP1/LAP3/PRODH2/SAT2/ALDH18A1/SMOX/NOS2/ALDH3A2/GAMT/ALDH7A1/CNDP2/CKB/AZIN2/GATM/PYCR2/ODC1/AOC1/SAT1/ALDH4A1/AMD1/CKMT2/AGMAT/SMS/GOT1L1	39
KEGG	hsa04913	Ovarian steroidogenesis	39/5985	51/8135	0.3865	0.5179	0.3542	BMP15/ADCY6/CGA/CYP1A1/ADCY7/CYP1B1/HSD17B7/STAR/IGF1R/PLA2G4F/SCARB1/CYP2J2/PLA2G4A/INS/ADCY9/ADCY8/PRKACA/LDLR/HSD17B1/ALOX5/FSHR/ACOT4/JMJD7-PLA2G4B/CYP11A1/ACOT1/ACOT2/AKR1C3/HSD3B1/ADCY5/PTGS2/PRKACB/BMP6/CYP17A1/FSHB/LHB/ADCY3/HSD17B2/CYP19A1/PRKACG	39
KEGG	hsa03420	Nucleotide excision repair	36/5985	47/8135	0.3892	0.5179	0.3542	XPC/CCNH/DDB1/CUL4B/ERCC4/XPA/RFC3/POLD1/ERCC5/RPA1/RPA2/PCNA/GTF2H2C/GTF2H3/POLD4/ERCC2/RFC1/GTF2H2/POLE3/RFC2/CUL4A/CETN2/RFC4/POLE4/ERCC6/DDB2/MNAT1/POLE/POLD3/CDK7/GTF2H1/RPA4/RFC5/RAD23A/ERCC1/POLD2	36
KEGG	hsa04973	Carbohydrate digestion and absorption	36/5985	47/8135	0.3892	0.5179	0.3542	ATP1B3/AKT2/MGAM/PLCB3/HK1/SLC37A4/TAS1R2/PIK3CB/HK3/ATP1B2/ATP1A3/ATP1A1/AKT3/PIK3CD/G6PC2/PLCB4/SLC5A1/G6PC3/PIK3R3/GNAT3/SLC2A5/CACNA1D/AMY1A/AMY1B/AMY1C/AMY2A/LCT/ATP1A2/PLCB2/PIK3R2/AMY2B/PIK3CA/AKT1/HK2/PLCB1/G6PC	36
KEGG	hsa00513	Various types of N-glycan biosynthesis	30/5985	39/8135	0.3948	0.5233	0.3579	B4GALT1/ALG12/MGAT4B/MAN1A2/B4GALNT4/MGAT2/MAN2A1/DDOST/DAD1/RPN1/CHST9/ALG11/ALG13/MAN1C1/STT3B/MGAT4C/HEXB/MGAT4A/TUSC3/MGAT1/ALG2/B4GALT3/STT3A/B4GALNT3/MAN1A1/B4GALT2/ST3GAL3/RPN2/HEXA/MAN2A2	30
KEGG	hsa04622	RIG-I-like receptor signaling pathway	53/5985	70/8135	0.4004	0.5286	0.3615	NFKBIB/DDX3X/OTUD5/IFNA10/IFNA16/NFKBIA/IFNA14/TRADD/IFNA17/SIKE1/TRAF6/FADD/ATG5/IFNA13/IRF3/NLRX1/MAPK8/MAP3K7/IFNA4/MAVS/CHUK/IFIH1/MAPK9/TRIM25/IFNK/IFNA7/IRF7/IKBKG/ATG12/DHX58/ISG15/CXCL10/IFNW1/IFNA1/IFNE/IKBKE/RNF125/IFNA5/TRAF2/CASP10/CYLD/IFNA8/IFNA6/TRAF3/IFNA21/IFNA2/DDX58/CXCL8/TANK/MAPK14/MAPK13/NFKB1/IL12A	53
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	18/5985	23/8135	0.4061	0.533	0.3645	GLS/ATP1B3/CA2/SLC9A3/AQP1/CA4/GLS2/MDH1/ATP1B2/ATP1A3/SLC38A3/ATP1A1/SLC25A10/PCK2/GLUD2/ATP1A2/SLC4A4/GLUD1	18
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	15/5985	19/8135	0.4087	0.533	0.3645	IDH1/CS/AADAT/GOT2/GPT2/GPT/ACO2/ACO1/NAGS/IDH3B/IDH2/BCAT2/IDH3G/BCAT1/GOT1L1	15
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	12/5985	15/8135	0.4107	0.533	0.3645	GBGT1/ST3GAL2/GLA/FUT2/HEXB/NAGA/A4GALT/B3GALT5/ST3GAL1/HEXA/FUT9/ST8SIA1	12
KEGG	hsa00240	Pyrimidine metabolism	44/5985	58/8135	0.4109	0.533	0.3645	ENTPD4/ENTPD6/AK9/NME6/DCK/ENPP3/NME7/NT5C2/NT5M/TYMP/DCTPP1/DPYD/RRM2B/DCTD/CANT1/NUDT2/NME3/NT5C3A/TK2/CDA/DHODH/CMPK1/ENTPD1/UCK1/ENTPD5/UCKL1/ENTPD3/ASMTL/NT5C1B-RDH14/NT5C1B/DPYS/DUT/NT5C1A/TYMS/HDDC2/UMPS/CAD/CMPK2/UPP1/NT5C/NME4/DTYMK/RRM2/UPP2	44
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	9/5985	11/8135	0.4117	0.533	0.3645	VKORC1/COQ5/COQ6/HPD/TAT/NQO1/GGCX/COQ3/VKORC1L1	9
KEGG	hsa04114	Oocyte meiosis	98/5985	131/8135	0.4171	0.5378	0.3678	YWHAE/ANAPC15/PPP2R1A/SPDYE1/SPDYE2B/SPDYE5/SPDYE6/SMC1A/PPP1CC/FBXW11/YWHAB/REC8/YWHAG/ITPR2/ADCY6/PPP1CB/PPP3CC/CUL1/PPP2R5B/PLK1/ADCY7/ANAPC16/SPDYE2/ANAPC13/ESPL1/CALM2/CALM3/PPP2R1B/ANAPC5/AR/PPP2CA/CDC23/CCNE2/CPEB1/STAG3/CPEB4/SLK/CALML5/PTTG2/CALML4/IGF1R/SMC1B/CAMK2G/PPP3CA/CALML3/RPS6KA1/CALML6/INS/ADCY9/RPS6KA3/ADCY8/CALM1/PRKACA/MAD2L2/ANAPC7/ANAPC10/PPP2R5C/CCNB1/CPEB2/BTRC/CCNB2/ANAPC2/CDK2/PKMYT1/PGR/CPEB3/MAD1L1/RPS6KA6/YWHAQ/PPP2R5D/ITPR3/FBXO43/PPP3CB/PPP1CA/ADCY5/YWHAH/CAMK2D/PRKACB/CDC16/MOS/CDC20/SMC3/BUB1/ITPR1/MAPK1/MAPK3/RPS6KA2/MAPK14/MAP2K1/CCNE1/MAPK13/ADCY3/PPP3R1/CDK1/CAMK2B/PRKACG/YWHAZ/PPP2R5A	98
KEGG	hsa00510	N-Glycan biosynthesis	38/5985	50/8135	0.4186	0.5378	0.3678	ALG5/ST6GAL1/B4GALT1/ALG12/MGAT4B/MAN1A2/MGAT2/MAN2A1/DDOST/DAD1/DOLPP1/RPN1/ALG6/ALG11/ALG13/MAN1C1/DPM2/STT3B/ALG10/MGAT3/MGAT4C/MGAT4A/TUSC3/MGAT1/ALG8/ALG2/ALG10B/B4GALT3/STT3A/GANAB/DPM1/DPAGT1/DOLK/MAN1A1/B4GALT2/RPN2/MAN2A2/DPM3	38
KEGG	hsa04658	Th1 and Th2 cell differentiation	69/5985	92/8135	0.4302	0.5485	0.3751	IL2RG/NFKBIB/JAK3/NFKBIA/JUN/JAK1/MAML1/PPP3CC/RBPJ/IL12RB1/MAPK8/IFNGR2/STAT5B/CHUK/MAPK9/IL5/HLA-DPA1/IKBKG/IFNGR1/PPP3CA/DLL1/CD247/HLA-DMB/IL4/LCK/HLA-DRB1/HLA-DQA2/HLA-DRA/HLA-DMA/RBPJL/STAT5A/NFATC2/HLA-DQB1/IL2/NOTCH1/STAT1/HLA-DOB/TBX21/HLA-DRB4/IFNG/PPP3CB/HLA-DOA/IL2RB/TYK2/FOS/NOTCH2/PRKCQ/RUNX3/IL4R/HLA-DPB1/DLL4/JAK2/MAPK1/ZAP70/IL2RA/MAPK3/DLL3/STAT4/MAPK14/HLA-DQA1/IL12RB2/NOTCH3/MAF/MAML2/MAPK13/PPP3R1/NFKB1/CD3G/IL12A	69
KEGG	hsa05222	Small cell lung cancer	69/5985	92/8135	0.4302	0.5485	0.3751	TP53/MAX/RXRB/ZBTB17/LAMB1/NFKBIA/CDK6/ITGB1/SKP2/AKT2/TRAF6/CDKN1B/XIAP/RXRA/CCNE2/CHUK/PTK2/COL4A1/PIK3CB/IKBKG/GADD45A/TRAF1/CASP9/LAMC1/ITGA2B/COL4A2/BAX/APAF1/AKT3/CDK4/E2F3/RB1/LAMB2/PIK3CD/BCL2/NOS2/TRAF4/CKS1B/BIRC7/LAMB3/PIK3R3/POLK/CDK2/LAMA2/PTEN/GADD45B/TRAF2/DDB2/FHIT/TRAF3/CDKN2B/PTGS2/FN1/LAMA5/CKS2/PIK3R2/PIK3CA/AKT1/CDKN1A/ITGA2/BAK1/LAMC2/LAMC3/CCNE1/NFKB1/ITGA3/ITGA6/BCL2L1/BIRC3	69
KEGG	hsa00040	Pentose and glucuronate interconversions	26/5985	34/8135	0.4369	0.5548	0.3794	UGT1A10/UGT1A4/UGT1A6/RPEL1/UGP2/UGT1A1/UGT1A8/UGT1A9/GUSB/UGT2B15/RPE/CRYL1/XYLB/SORD/UGDH/AKR1A1/UGT1A3/UGT1A5/UGT2A3/KL/UGT1A7/DHDH/AKR1B1/UGT2A1/UGT2A2/AKR1B10	26
KEGG	hsa01523	Antifolate resistance	23/5985	30/8135	0.4423	0.5578	0.3815	ABCC1/FPGS/FOLR3/ALOX12/CHUK/IKBKG/SHMT1/GGH/FOLR1/MTHFR/ATIC/ABCG2/ABCC3/ABCC2/ABCC5/IL1B/SLC46A1/SLC19A1/TYMS/FOLR2/SHMT2/NFKB1/IL6	23
KEGG	hsa00983	Drug metabolism - other enzymes	60/5985	80/8135	0.4426	0.5578	0.3815	CYP2A7/UGT1A10/UGT1A4/UGT1A6/NME6/GSTA3/NAT2/XDH/GSTM5/UGT1A1/UGT1A8/UGT1A9/MGST1/NME7/GUSB/UGT2B15/IMPDH2/IMPDH1/TYMP/DPYD/RRM2B/GSTA4/NME3/NAT1/HPRT1/GSTO1/GSTM3/MGST2/CES2/TK2/CDA/CES1/GMPS/ITPA/CMPK1/GSTM2/UCK1/UGT1A3/UGT1A5/UGT2A3/CYP2A6/UCKL1/UGT1A7/DPYS/DUT/GSTA1/GSTM1/GSTM4/UMPS/UGT2A1/UGT2A2/CYP2E1/GSTP1/UPP1/GSTT2/NME4/RRM2/TPMT/UPP2/MPO	60
KEGG	hsa00790	Folate biosynthesis	20/5985	26/8135	0.4482	0.5628	0.3849	PTS/PCBD1/SPR/FPGS/ALPP/CBR1/PAH/QDPR/TPH2/MOCS2/ALPI/TH/GGH/TPH1/ALPL/AKR1C3/PCBD2/AKR1B1/AKR1B10/MOCS1	20
KEGG	hsa03022	Basal transcription factors	34/5985	45/8135	0.4575	0.5723	0.3914	TAF1/TAF10/CCNH/TAF13/TAF4/TAF8/TBP/GTF2F2/GTF2H2C/TAF5L/GTF2H3/TAF9B/GTF2A1/ERCC2/GTF2H2/GTF2E1/TAF11/TAF7/TAF9/GTF2I/GTF2F1/TAF6/TBPL1/GTF2B/TAF12/TAF6L/TAF3/GTF2IRD1/MNAT1/TAF1L/CDK7/GTF2H1/TAF4B/GTF2A1L	34
KEGG	hsa03018	RNA degradation	59/5985	79/8135	0.4692	0.5839	0.3993	DDX6/CNOT1/PABPC3/CNOT6L/EXOSC3/LSM3/PABPC1/CNOT3/PATL1/HSPD1/BTG2/LSM5/MPHOSPH6/XRN1/C1D/EXOSC9/EXOSC5/PABPC1L2A/PABPC1L2B/EXOSC6/EXOSC8/BTG4/BTG1/HSPA9/CNOT7/ENO3/CNOT4/DCP1B/DIS3L/PABPC4L/PARN/WDR61/CNOT8/CNOT10/PNLDC1/BTG3/ENO1/PFKM/LSM4/TTC37/PABPC5/EXOSC7/TOB2/DCPS/EXOSC10/DIS3/CNOT6/ENO2/EXOSC4/PABPC1L/LSM7/LSM6/PAN2/PABPC4/EDC3/TOB1/DHX36/XRN2/PFKP	59
KEGG	hsa05216	Thyroid cancer	28/5985	37/8135	0.4703	0.5839	0.3993	TFG/TP53/RXRB/HRAS/KRAS/TPR/BRAF/NCOA4/NRAS/RXRA/NTRK1/GADD45A/CTNNB1/TPM3/TCF7L1/BAX/MAP2K2/POLK/GADD45B/CDH1/PPARG/DDB2/CCDC6/MAPK1/CDKN1A/MAPK3/MAP2K1/BAK1	28
KEGG	hsa04520	Adherens junction	53/5985	71/8135	0.4799	0.5936	0.406	PTPN1/PTPRJ/EGFR/SMAD3/ACTG1/ACTB/SMAD4/CSNK2A1/ACTN4/CSNK2B/WASF3/MAP3K7/ACTN1/CREBBP/IGF1R/PTPRF/PARD3/CTNNA3/CTNNB1/ERBB2/RAC1/TCF7L1/CDC42/MET/SRC/FGFR1/IQGAP1/TGFBR1/WASL/RHOA/RAC3/TGFBR2/EP300/WASF1/CDH1/RAC2/FYN/WASF2/FER/TJP1/YES1/CTNNA1/NLK/SSX2IP/WAS/MAPK1/SORBS1/MAPK3/ACP1/CSNK2A2/PTPN6/VCL/SNAI2	53
KEGG	hsa00591	Linoleic acid metabolism	22/5985	29/8135	0.4858	0.5965	0.4079	CYP2C9/PLA2G2D/PLA2G1B/PLA2G4F/PLA2G2F/CYP2J2/PLA2G2A/PLA2G4A/PLA2G12A/JMJD7-PLA2G4B/CYP1A2/PLA2G2E/PLA2G12B/ALOX15/PLA2G3/CYP2C8/PLA2G10/PLA2G6/CYP2C19/CYP2E1/PLA2G5/PLB1	22
KEGG	hsa04744	Phototransduction	22/5985	29/8135	0.4858	0.5965	0.4079	GUCA1A/SLC24A1/GRK7/PDE6G/CALM2/CALM3/CNGA1/CALML5/CALML4/PDE6A/GNGT1/CALML3/CALML6/GNAT2/GRK1/CALM1/SAG/GUCA1C/CNGB1/GUCY2D/GNAT1/RGS9	22
KEGG	hsa04727	GABAergic synapse	66/5985	89/8135	0.5054	0.6183	0.4228	GLS/GNG2/GABRG2/SLC38A5/GNG11/GNG4/ABAT/GABARAPL2/ADCY6/HAP1/GABRA4/ADCY7/NSF/GNB2/GLS2/GNG5/KCNJ6/GABBR1/GABARAPL1/GNG10/GABRB3/GABARAP/GNGT1/GNG7/ADCY9/ADCY8/SLC6A12/PRKCA/GABBR2/SRC/GNG8/PRKACA/SLC38A3/GABRE/SLC38A2/CACNA1F/CACNA1A/SLC32A1/GABRB2/PLCL1/GLUL/GNG13/TRAK2/GABRP/GABRQ/PRKCG/GABRR1/SLC12A5/GNG3/CACNA1C/CACNA1D/GABRR2/ADCY5/GNAI2/PRKACB/GNAI3/GABRD/GABRA3/GNG12/GNAO1/SLC38A1/SLC6A11/ADCY3/GNB4/PRKACG/GAD2	66
KEGG	hsa00500	Starch and sucrose metabolism	27/5985	36/8135	0.5098	0.6208	0.4245	UGP2/ENPP3/MGAM/HK1/PGM1/GBE1/PYGL/PGM2L1/HK3/TREH/GYG1/PGM2/G6PC2/G6PC3/GYS1/AMY1A/AMY1B/AMY1C/AMY2A/GCK/GYS2/AMY2B/GPI/HK2/GAA/PYGM/G6PC	27
KEGG	hsa01232	Nucleotide metabolism	63/5985	85/8135	0.5111	0.6208	0.4245	AK8/GMPR/ENTPD4/ENTPD6/AK9/GDA/NME6/XDH/AK7/DCK/ENPP3/NME7/NT5C2/NT5M/IMPDH2/AK6/IMPDH1/PNP/TYMP/DCTPP1/AK4/RRM2B/DCTD/CANT1/AK3/NME3/HPRT1/ADSL/NT5C3A/TK2/CDA/AMPD2/GMPS/ITPA/CMPK1/ENTPD1/AMPD1/UCK1/GMPR2/AK2/ADA/ENTPD5/UCKL1/ENTPD3/ASMTL/NT5C1B-RDH14/LACC1/NT5C1B/DUT/NT5C1A/TYMS/HDDC2/ENTPD2/CMPK2/APRT/UPP1/AMPD3/GUK1/NT5C/NME4/DTYMK/RRM2/UPP2	63
KEGG	hsa00480	Glutathione metabolism	43/5985	58/8135	0.5296	0.6409	0.4383	PRDX6/GPX1/GSTA3/IDH1/GPX4/GSTM5/MGST1/GCLM/NAT8B/GPX2/GPX3/G6PD/NAT8/RRM2B/GSTA4/CHAC1/GPX5/GSTO1/GSTM3/MGST2/LAP3/GCLC/TXNDC12/GGT5/GSTM2/IDH2/GPX7/GSTA1/GSTM1/GSS/GSR/ODC1/GGT6/GSTM4/CHAC2/GSTK1/GSTP1/SMS/GGT7/GSTT2/RRM2/GGT1/LANCL1	43
KEGG	hsa04920	Adipocytokine signaling pathway	51/5985	69/8135	0.5372	0.6478	0.443	NFKBIB/RXRB/PTPN11/CPT1A/NFKBIA/ADIPOR1/TRADD/AKT2/SOCS3/ACSL1/MTOR/CD36/PRKAG3/MAPK8/RXRA/PPARGC1A/TNFRSF1A/CPT1B/CHUK/MAPK9/IRS1/IKBKG/ADIPOR2/CPT1C/STK11/ACSL6/AKT3/POMC/ACACB/ACSL4/TNFRSF1B/G6PC2/LEPR/ACSBG2/G6PC3/ACSL3/PRKAG1/TRAF2/PRKAB1/PCK2/PRKCQ/SLC2A1/STAT3/AGRP/JAK2/AKT1/IRS2/PRKAA1/ACSBG1/NFKB1/G6PC	51
KEGG	hsa04977	Vitamin digestion and absorption	18/5985	24/8135	0.5435	0.653	0.4466	ABCC1/CUBN/SLC23A1/MMACHC/LMBRD1/BTD/RBP2/APOA4/SLC5A6/SCARB1/APOA1/SLC19A3/TCN2/SLC46A1/SLC19A1/SLC52A3/SLC19A2/PLB1	18
KEGG	hsa04914	Progesterone-mediated oocyte maturation	75/5985	102/8135	0.5555	0.6644	0.4544	ANAPC15/KIF22/ARAF/SPDYE1/SPDYE2B/SPDYE5/SPDYE6/KRAS/BRAF/CCNB3/AKT2/ADCY6/RAF1/PLK1/ADCY7/CCNA2/ANAPC16/SPDYE2/ANAPC13/FZR1/HSP90AB1/MAPK8/ANAPC5/CDC23/CPEB1/CPEB4/MAPK9/IGF1R/PIK3CB/RPS6KA1/INS/ADCY9/RPS6KA3/ADCY8/CCNA1/PRKACA/MAD2L2/AKT3/ANAPC7/ANAPC10/PIK3CD/CCNB1/CPEB2/PIK3R3/CCNB2/ANAPC2/CDK2/PKMYT1/PGR/CPEB3/MAD1L1/RPS6KA6/HSP90AA1/ADCY5/STK10/GNAI2/PRKACB/CDC16/MOS/GNAI3/PIK3R2/BUB1/MAPK1/PIK3CA/AKT1/MAPK3/CDC25A/RPS6KA2/MAPK14/MAP2K1/PDE3B/MAPK13/ADCY3/CDK1/PRKACG	75
KEGG	hsa00100	Steroid biosynthesis	15/5985	20/8135	0.559	0.6644	0.4544	EBP/CYP51A1/HSD17B7/FDFT1/CYP2R1/SC5D/DHCR24/CYP27B1/LIPA/LBR/SOAT1/SQLE/DHCR7/MSMO1/TM7SF2	15
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	15/5985	20/8135	0.559	0.6644	0.4544	B3GAT3/B3GALT6/XYLT1/CHST11/XYLT2/CSGALNACT1/CHST14/CHST15/CHST3/CHST12/B4GALT7/CHST13/CHSY3/DSE/CHST7	15
KEGG	hsa00360	Phenylalanine metabolism	12/5985	16/8135	0.5784	0.685	0.4685	MIF/AOC3/GOT2/PAH/AOC2/IL4I1/ALDH3B1/HPD/DDC/TAT/ALDH3A1/GOT1L1	12
KEGG	hsa00190	Oxidative phosphorylation	98/5985	134/8135	0.5904	0.6968	0.4765	SDHC/ND3/COX7B/ND6/NDUFA10/COX6C/UQCRB/COX7C/SDHD/NDUFA1/ND2/NDUFB7/NDUFB6/ATP6V1B2/ATP6V0C/ATP6V0E1/COX3/UQCRH/UQCRHL/COX4I1/NDUFS5/ATP6V0D2/COX1/ATP6V0B/UQCR10/NDUFA4/NDUFS7/ATP6V1C2/COX2/NDUFA3/NDUFA11/NDUFA6/COX8A/ATP6V1G3/NDUFV1/ATP6V1H/COX10/NDUFA8/ATP6/NDUFA2/COX5B/COX6B2/ATP6V0D1/COX11/ATP6V1E1/ATP6V1E2/UQCRQ/COX6A1/NDUFA13/CYC1/NDUFB1/ATP6V1A/NDUFA7/ATP6V1F/COX17/COX7A1/ATP6V1C1/ATP6AP1/UQCRFS1/NDUFB2/NDUFB10/SDHB/NDUFS6/NDUFS3/ND4/NDUFV3/ATP6V1B1/ATP12A/UQCRC1/NDUFA9/NDUFS4/NDUFB5/UQCRC2/PPA1/ATP4B/NDUFA4L2/COX7A2L/UQCR11/NDUFB9/NDUFV2/NDUFB8/NDUFS1/ATP6V0E2/NDUFS2/NDUFB4/COX6B1/COX15/NDUFB3/ATP6V0A1/COX5A/PPA2/ATP6V1G2/ATP6V1D/LHPP/ATP6V1G1/NDUFAB1/COX8C/TCIRG1	98
KEGG	hsa04923	Regulation of lipolysis in adipocytes	41/5985	56/8135	0.5929	0.6973	0.4769	AKT2/ADCY6/CGA/ADCY7/PRKG1/PTGS1/PNPLA2/ABHD5/MGLL/IRS1/PIK3CB/PLIN1/INS/ADCY9/ADCY8/AQP7/LOC100509620/PRKACA/NPR1/AKT3/PIK3CD/PIK3R3/ADORA1/TSHB/ADCY5/PTGS2/LIPE/GNAI2/ADRB2/PRKACB/GNAI3/PIK3R2/FABP4/PIK3CA/AKT1/IRS2/ADRB1/TSHR/PDE3B/ADCY3/PRKACG	41
KEGG	hsa04976	Bile secretion	65/5985	89/8135	0.6002	0.7034	0.481	SCT/SLC4A2/ATP1B3/UGT1A10/UGT1A4/CA2/UGT1A6/BAAT/SLC10A1/SLC4A5/ADCY6/AQP9/UGT1A1/UGT1A8/UGT1A9/SLC9A3/AQP1/EPHX1/ADCY7/UGT2B15/NR1H4/SLCO1A2/RXRA/SLC51B/SCARB1/ATP1B2/ADCY9/HMGCR/ATP1A3/ADCY8/PRKACA/LDLR/ATP1A1/SCTR/ABCG2/SLC27A5/ABCC3/SLC5A1/UGT1A3/UGT1A5/SULT2A1/UGT2A3/ABCC2/SLC10A2/ABCG8/UGT1A7/NCEH1/SLC51A/KCNN2/ADCY5/SLCO1B3/SLC22A8/ATP1A2/SLC2A1/PRKACB/SLC9A1/SLC4A4/SLC22A7/ABCB4/ABCB11/UGT2A1/UGT2A2/SLCO1B1/ADCY3/PRKACG	65
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	22/5985	30/8135	0.6054	0.707	0.4835	GLYCTK/CS/MDH2/HOGA1/ACAT1/CAT/ACSS1/HAO1/MDH1/PCCA/ACO2/HYI/SHMT1/DLD/ACO1/GLUL/PCCB/ACSS2/GRHPR/AGXT/GCSH/SHMT2	22
KEGG	hsa05131	Shigellosis	180/5985	247/8135	0.6312	0.7322	0.5007	PFN1/TP53/NFKBIB/CYTH1/MYL12A/MDM2/UBB/ARPC1B/EGFR/NFKBIA/ATG16L1/ARPC4/JUN/PIK3R4/ITGB1/RPS6KA5/CBX3/TRADD/FNBP1/AKT2/UBA52/U2AF1L4/FBXW11/ACTG1/TRAF6/GSK3B/UBE2D1/ITPR2/CTTN/ATG5/UBE2D3/ARHGEF2/ACTR3/ACTB/CUL1/CYTH4/RPS6KB2/DIAPH1/PLCB3/HK1/FOXO6/CSF2/ACTN4/CAPNS1/MTOR/ARPC1A/ARF6/PYCARD/TLN2/CYTH3/MAP1LC3B/UBE2NL/ACTR2/BECN1/IRF3/CD14/SHARPIN/MYD88/RRAGA/MAPK8/CD44/TAB1/ROCK1/RPS6KB1/ITGA5/MAP3K7/ACTN1/UBC/UBE2D2/TNFRSF1A/FNBP1L/ARPC5L/RRAGD/GSK3A/CALCOCO2/CHUK/PTK2/MAPK9/ROCK2/CRK/PIK3CB/IKBKG/WIPI2/TAB3/HK3/MAP1LC3A/PPID/ATG12/CAPN2/CASP4/TLR4/RAC1/ATG14/PIK3C3/RRAGC/UBE2N/CDC42/TLR5/PRKCD/SRC/BAX/PFN2/RNF31/RPTOR/MAP1LC3C/NAIP/PLCD4/AKT3/ARPC2/CAPN1/ATM/RBCK1/GLMN/PLCE1/CCL5/WASL/IL18/PIK3CD/PLCB4/PLCD3/BCL2/CASP1/RHOA/ELMO2/HCLS1/AKT1S1/VDAC1/BTRC/PIK3R3/MYL7/WASF1/MALT1/IL1R1/MYL9/BNIP3/TRAF2/PLCG2/MAP1LC3B2/ITPR3/IL1B/CYTH2/WASF2/RIPK2/NOD1/ARF1/SQSTM1/PXN/FOXO1/TECPR1/MYLPF/PRKCQ/PLCB2/FOXO4/PIK3R2/MYL5/TAB2/MYL12B/ITPR1/CXCL8/MAPK1/PIK3CA/AKT1/MAPK3/MAPK14/BCAR1/HK2/PRKCE/U2AF1/ARPC3/NLRC4/UBE2V2/MAPK13/UBE2D4/FOXO3/RPS27A/NFKB1/PLCB1/VCL/BCL2L1/PLCD1	180
KEGG	hsa00051	Fructose and mannose metabolism	24/5985	33/8135	0.6313	0.7322	0.5007	TSTA3/GMPPA/HK1/PFKFB4/FPGT/KHK/TPI1/HK3/ALDOA/SORD/PFKFB3/GMPPB/PFKFB2/PMM1/FBP1/PFKM/ALDOC/GMDS/PMM2/FBP2/AKR1B1/HK2/AKR1B10/PFKP	24
KEGG	hsa00260	Glycine, serine and threonine metabolism	29/5985	40/8135	0.6399	0.7374	0.5043	GLYCTK/ALAS2/PGAM2/BHMT/AGXT2/ALAS1/DAO/AOC3/PGAM1/BPGM/AOC2/GCAT/PHGDH/PSAT1/SHMT1/DLD/SARDH/SDS/SDSL/GAMT/ALDH7A1/SRR/GRHPR/GATM/AGXT/GCSH/DMGDH/SHMT2/GNMT	29
KEGG	hsa05032	Morphine addiction	66/5985	91/8135	0.6415	0.7374	0.5043	GNG2/GABRG2/PDE4C/GNG11/GNG4/ADCY6/PDE7B/GABRA4/ADCY7/PDE4D/GNB2/PDE4A/GNG5/KCNJ6/GABBR1/GNG10/GABRB3/KCNJ9/GNGT1/GRK6/GNG7/ADCY9/ADCY8/PDE4B/PRKCA/GABBR2/GNG8/PRKACA/GABRE/PDE8B/CACNA1A/SLC32A1/GABRB2/GNG13/GABRP/KCNJ3/GABRQ/PRKCG/GABRR1/OPRM1/GNG3/PDE7A/PDE3A/ADORA1/GRK5/GABRR2/ADCY5/PDE1C/GNAI2/PRKACB/GNAI3/ARRB2/GABRD/GABRA3/GNG12/PDE8A/GNAO1/PDE1B/PDE11A/DRD1/PDE3B/ADCY3/GNB4/ARRB1/PRKACG/PDE2A	66
KEGG	hsa00340	Histidine metabolism	16/5985	22/8135	0.6424	0.7374	0.5043	ALDH9A1/ALDH1B1/HDC/HAL/ALDH2/ALDH3B1/CNDP1/FTCD/ALDH3A2/ALDH7A1/CNDP2/ALDH3A1/AMDHD1/UROC1/AOC1/ASPA	16
KEGG	hsa00564	Glycerophospholipid metabolism	71/5985	98/8135	0.6494	0.7428	0.508	DGKE/LPCAT3/CDIPT/MBOAT7/MBOAT2/AGPAT4/LYPLA1/ETNK2/LYPLA2/GPD2/AGPAT5/GNPAT/AGPAT1/PTDSS2/DGKA/LPIN2/PNPLA6/ETNK1/PLA2G2D/DGKK/LCLAT1/PLA2G1B/PLA2G4F/PCYT1B/PLA2G2F/PLA2G2A/CEPT1/PLA2G4A/PCYT1A/PISD/PLA2G12A/CHPT1/CHKB/PNPLA7/PTDSS1/CDS1/GPAM/PGS1/DGKG/JMJD7-PLA2G4B/LPCAT2/PLD1/DGKZ/MBOAT1/CDS2/LCAT/PLA2G2E/LPGAT1/LPCAT4/PEMT/PLA2G12B/CHKA/CRLS1/DGKQ/LPCAT1/GPAT2/PLA2G3/GPD1L/GPD1/PLA1A/PLA2G10/PLA2G6/DGKH/PLA2G5/DGKB/AGPAT2/PLA2G15/PLD3/GPCPD1/PLB1/ACHE	71
KEGG	hsa00512	Mucin type O-glycan biosynthesis	26/5985	36/8135	0.6548	0.7464	0.5104	GALNT7/GALNT14/ST3GAL2/ST6GALNAC2/GALNT9/ST6GALNAC4/GALNT11/GCNT4/GALNTL6/ST6GALNAC3/B3GNT6/GALNT3/B3GNT3/GALNT6/ST6GALNAC1/B4GALT5/GALNT15/GALNT2/C1GALT1C1/GALNT12/GALNT13/GALNT1/ST3GAL1/GALNT4/POC1B-GALNT4/GALNTL5	26
KEGG	hsa00982	Drug metabolism - cytochrome P450	52/5985	72/8135	0.6599	0.7496	0.5127	CYP2A7/UGT1A10/UGT1A4/UGT1A6/FMO2/GSTA3/CYP3A5/GSTM5/UGT1A1/UGT1A8/UGT1A9/MGST1/UGT2B15/CYP2B6/FMO4/CYP2C9/AOX1/ADH1B/GSTA4/CYP2D6/ALDH3B1/ADH4/GSTO1/GSTM3/MGST2/FMO1/GSTM2/ADH5/FMO5/UGT1A3/UGT1A5/ADH7/UGT2A3/CYP2A6/FMO3/ALDH3A1/CYP1A2/UGT1A7/GSTA1/GSTM1/CYP2C8/ADH1A/GSTM4/ADH6/CYP2C19/UGT2A1/UGT2A2/GSTK1/CYP2E1/GSTP1/GSTT2/ADH1C	52
KEGG	hsa00140	Steroid hormone biosynthesis	44/5985	61/8135	0.6628	0.7505	0.5133	UGT1A10/UGT1A4/UGT1A6/CYP3A5/UGT1A1/UGT1A8/UGT1A9/CYP11B2/CYP1A1/UGT2B15/HSD17B12/CYP1B1/HSD17B7/CYP3A7/HSD11B1/SRD5A1/HSD17B1/HSD11B2/HSD17B3/SRD5A2/AKR1D1/CYP11A1/UGT1A3/UGT1A5/UGT2A3/AKR1C2/SULT1E1/CYP1A2/AKR1C3/LRTOMT/UGT1A7/HSD3B1/STS/COMT/HSD17B8/CYP17A1/AKR1C4/UGT2A1/UGT2A2/CYP2E1/HSD17B2/CYP19A1/CYP11B1/DHRS11	44
KEGG	hsa04215	Apoptosis - multiple species	23/5985	32/8135	0.6715	0.7577	0.5182	FADD/XIAP/BCL2L11/BECN1/MAPK8/TNFRSF1A/MAPK9/BID/CASP9/HTRA2/PMAIP1/BAX/APAF1/BCL2/BIRC7/BOK/DIABLO/NGFR/BIRC6/BAK1/BIRC5/BCL2L1/BIRC3	23
KEGG	hsa04726	Serotonergic synapse	83/5985	115/8135	0.6778	0.7607	0.5202	GNG2/HRAS/ARAF/DUSP1/KRAS/GNG11/GNG4/BRAF/ITPR2/RAF1/SLC18A2/NRAS/HTR1D/PLCB3/HTR2B/GNB2/PTGS1/CYP2C18/ALOX12/CYP2C9/GNG5/KCNJ6/HTR1B/GNG10/GABRB3/TPH2/KCNJ9/GNGT1/PLA2G4F/CYP2D6/CYP2J2/PLA2G4A/GNG7/PRKCA/GNG8/PRKACA/KCND2/ALOX15B/SLC6A4/ALOX5/HTR7/CACNA1F/CACNA1A/GABRB2/DDC/TPH1/GNG13/PLCB4/JMJD7-PLA2G4B/KCNJ3/PRKCG/HTR4/HTR3B/GNAQ/GNG3/CACNA1C/ITPR3/CACNA1D/KCNN2/ALOX15/ADCY5/PTGS2/TRPC1/GNAI2/PRKACB/PLCB2/GNAI3/CYP2C8/CYP4X1/HTR2A/ITPR1/MAPK1/GNG12/CYP2C19/MAPK3/HTR2C/GNAO1/MAP2K1/APP/HTR1F/GNB4/PLCB1/PRKACG	83
KEGG	hsa04660	T cell receptor signaling pathway	75/5985	104/8135	0.6787	0.7607	0.5202	NFKBIB/HRAS/KRAS/DLG1/NFKBIA/JUN/AKT2/GSK3B/RAF1/PPP3CC/NRAS/SOS2/CSF2/PDPK1/PAK4/MAPK8/MAP3K7/CHUK/MAPK9/IL5/PIK3CB/IKBKG/PPP3CA/PAK2/CD247/PAK1/CDC42/VAV1/IL4/LCK/GRB2/AKT3/CDK4/CD40LG/NFATC2/PIK3CD/RHOA/PAK3/MAP2K2/IL2/CD8A/PIK3R3/IL10/MALT1/IFNG/ITK/PPP3CB/FYN/FOS/CARD11/CTLA4/VAV2/PRKCQ/PIK3R2/PTPRC/VAV3/MAPK1/PIK3CA/AKT1/ZAP70/MAPK3/MAPK14/MAP2K1/LCP2/MAP2K7/PAK6/MAPK13/CBLB/PPP3R1/SOS1/NFKB1/PTPN6/PDCD1/CD3G/CD28	75
KEGG	hsa04730	Long-term depression	43/5985	60/8135	0.6914	0.7703	0.5268	PPP2R1A/HRAS/ARAF/KRAS/BRAF/GNAZ/ITPR2/RAF1/NRAS/PLCB3/PRKG1/GRM1/PPP2R1B/PPP2CA/GNA13/IGF1R/NOS1/PLA2G4F/LYN/PLA2G4A/GNA11/PRKCA/GNA12/CACNA1A/GUCY1A2/PLCB4/JMJD7-PLA2G4B/MAP2K2/PRKCG/GNAQ/ITPR3/GNAI2/PLCB2/GNAI3/GRIA2/ITPR1/MAPK1/MAPK3/GNAO1/MAP2K1/GRID2/PPP1R17/PLCB1	43
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	56/5985	78/8135	0.6919	0.7703	0.5268	CYP2A7/UGT1A10/UGT1A4/UGT1A6/GSTA3/CYP3A5/GSTM5/UGT1A1/UGT1A8/UGT1A9/MGST1/CYP1A1/EPHX1/UGT2B15/CYP1B1/AKR7A3/CYP2B6/AKR7A2/CYP2C9/ADH1B/GSTA4/CBR1/CYP2D6/HSD11B1/ALDH3B1/ADH4/GSTO1/GSTM3/MGST2/GSTM2/ADH5/UGT1A3/UGT1A5/ADH7/SULT2A1/UGT2A3/CYP2A6/ALDH3A1/CYP1A2/CYP2F1/UGT1A7/GSTA1/DHDH/GSTM1/CYP2A13/ADH1A/GSTM4/ADH6/UGT2A1/UGT2A2/GSTK1/CYP2E1/GSTP1/CYP2S1/GSTT2/ADH1C	56
KEGG	hsa00565	Ether lipid metabolism	35/5985	49/8135	0.6991	0.7758	0.5306	PAFAH1B2/GDPD1/PLA2G2D/PLA2G1B/PLA2G4F/PLA2G2F/PLA2G2A/CEPT1/PLA2G4A/PLA2G7/PLA2G12A/CHPT1/ENPP2/PAFAH1B3/PAFAH2/TMEM86B/UGT8/JMJD7-PLA2G4B/AGPS/LPCAT2/PLD1/PLA2G2E/LPCAT4/PLA2G12B/LPCAT1/PLA2G3/GDPD3/GAL3ST1/PLA2G10/PLA2G6/ENPP6/PLA2G5/PAFAH1B1/PLD3/PLB1	35
KEGG	hsa04710	Circadian rhythm	22/5985	31/8135	0.7107	0.786	0.5375	PER1/FBXW11/NR1D1/CUL1/PRKAG3/NPAS2/BHLHE40/PER2/CREB1/BTRC/PER3/PRKAG1/RORC/CRY1/RORB/PRKAB1/CRY2/RORA/FBXL3/PRKAA1/BHLHE41/ARNTL	22
KEGG	hsa05100	Bacterial invasion of epithelial cells	55/5985	77/8135	0.7162	0.789	0.5396	SHC1/ARPC1B/ARPC4/ITGB1/CLTC/ACTG1/CTTN/CLTA/ACTR3/ACTB/CAV3/DNM2/ARPC1A/ACTR2/ITGA5/CAV1/ARPC5L/PTK2/CAV2/CRK/PIK3CB/CTNNA3/CTNNB1/RAC1/CDC42/MET/SRC/MAD2L2/RHOG/ARPC2/ARHGAP10/WASL/PIK3CD/RHOA/ELMO2/HCLS1/PIK3R3/WASF1/SHC3/ELMO3/GAB1/CDH1/ARHGEF26/WASF2/PXN/DNM3/FN1/CTNNA1/PIK3R2/PIK3CA/BCAR1/ARPC3/SHC2/CLTCL1/VCL	55
KEGG	hsa00450	Selenocompound metabolism	12/5985	17/8135	0.7201	0.789	0.5396	PSTK/TXNRD1/PAPSS1/SEPSECS/TXNRD3/SEPHS2/MARS2/SCLY/TXNRD2/INMT/SEPHS1/MTR	12
KEGG	hsa05203	Viral carcinogenesis	147/5985	204/8135	0.7205	0.789	0.5396	YWHAE/TP53/DDX3X/ATF6B/JAK3/HRAS/MDM2/ATF2/MAPKAPK2/KRAS/NFKB2/RANBP1/DLG1/NFKBIA/JUN/CDK6/SKP2/DDB1/JAK1/TRADD/YWHAB/HLA-C/HLA-G/TBP/CCR3/HDAC3/YWHAG/CREB5/CDKN1B/NRAS/ATP6V0D2/SRF/HLA-E/ACTN4/CCNA2/DNAJA3/RBPJ/GTF2H2C/CREB3L3/IRF3/HDAC8/PKM/HLA-A/IL6ST/GTF2H3/CCND2/CREB3/STAT5B/HLA-B/USP7/ACTN1/CREBBP/CCNE2/HDAC5/CREB3L4/SYK/RBL1/HLA-F/CCR5/GTF2A1/PIK3CB/IRF7/IKBKG/GTF2H2/TRAF1/ATP6V0D1/LYN/GTF2E1/KAT2A/RAC1/MRPS18B/KAT2B/HDAC11/CDC42/VAC14/CCNA1/SRC/PMAIP1/BAX/PRKACA/HDAC4/BAD/GRB2/CDK4/RASA2/CREB1/RB1/RBPJL/STAT5A/PIK3CD/RHOA/HDAC10/CHEK1/TBPL1/HPN/GTF2B/EP300/PIK3R3/CDK2/EGR2/MAD1L1/SCIN/YWHAQ/ATF4/GSN/TRAF2/SCRIB/SNW1/HDAC2/HDAC9/TRAF3/PXN/CDKN2B/RBL2/YWHAH/GTF2H1/UBR4/PRKACB/EIF2AK2/CREB3L1/HDAC7/CDC20/PIK3R2/STAT3/CCR4/MAPK1/PIK3CA/CDKN1A/SP100/MAPK3/HDAC1/CCR8/SND1/EGR3/REL/IRF9/BAK1/UBE3A/CCNE1/CDKN2A/NFKB1/HDAC6/CDK1/VDAC3/PRKACG/GTF2A1L/YWHAZ	147
KEGG	hsa03440	Homologous recombination	29/5985	41/8135	0.7285	0.7952	0.5438	EME1/RAD52/PALB2/POLD1/RPA1/BRCA1/RPA2/XRCC3/RAD51B/BABAM1/POLD4/UIMC1/TOP3A/RAD51C/RAD51/ATM/SSBP1/TOP3B/POLD3/BRIP1/MUS81/RPA4/BARD1/SYCP3/BLM/NBN/BRCC3/RBBP8/POLD2	29
KEGG	hsa00920	Sulfur metabolism	7/5985	10/8135	0.7417	0.8069	0.5518	IMPAD1/SELENBP1/TST/ETHE1/PAPSS1/MPST/BPNT1	7
KEGG	hsa04742	Taste transduction	61/5985	86/8135	0.7553	0.8169	0.5587	TAS2R1/ADCY6/CALHM1/GABRA4/HTR1D/TAS2R38/TAS2R45/PLCB3/GRM1/TAS2R19/GABBR1/HTR1B/P2RY4/TAS1R2/SCNN1G/SCNN1A/ADCY8/TAS2R43/P2RX3/GABBR2/TAS2R50/PRKACA/SCN3A/TAS2R39/CACNA1A/TAS2R16/TAS1R1/GNG13/PLCB4/TAS2R41/SCN2A/TAS2R7/GNAT3/TAS2R5/TRPM5/HTR3B/TAS2R4/CACNA1C/ITPR3/TAS2R14/PDE1C/CHRM3/PRKACB/PLCB2/TAS2R3/TAS2R8/GABRA3/TAS2R13/HCN4/ENTPD2/P2RY1/TAS2R9/PDE1B/SCN9A/KCNK5/GRM4/ASIC2/SCNN1B/HTR1F/PLCB1/PRKACG	61
KEGG	hsa00515	Mannose type O-glycan biosynthesis	16/5985	23/8135	0.7557	0.8169	0.5587	B4GALT1/B3GAT2/POMGNT2/POMGNT1/POMK/POMT1/CHST10/FKTN/B3GAT1/POMT2/B4GALT3/FUT4/B4GALT2/ST3GAL3/B3GALNT2/FUT9	16
KEGG	hsa00514	Other types of O-glycan biosynthesis	33/5985	47/8135	0.7589	0.8176	0.5592	ST6GAL1/B4GALT1/GALNT7/GALNT14/OGT/GALNT9/POMT1/GXYLT1/GALNT11/RFNG/GALNTL6/POFUT1/GALNT3/POGLUT1/GALNT6/POMT2/GALNT15/GALNT2/C1GALT1C1/GALNT12/GXYLT2/B4GALT3/GALNT13/PLOD3/GALNT1/MFNG/POFUT2/GALNT4/POC1B-GALNT4/XXYLT1/B4GALT2/ST3GAL3/GALNTL5	33
KEGG	hsa04974	Protein digestion and absorption	73/5985	103/8135	0.7718	0.8261	0.5649	ATP1B3/COL1A1/CTRL/SLC3A1/SLC8A3/MME/CPA3/CELA2A/PRCP/KCNE3/KCNJ13/CELA2B/SLC9A3/COL17A1/SLC16A10/COL11A2/SLC7A9/COL5A3/COL6A3/SLC7A7/CPA1/COL2A1/COL1A2/COL4A1/COL6A1/COL11A1/ATP1B2/ATP1A3/COL4A2/CPB1/ELN/SLC3A2/COL22A1/SLC8A2/COL13A1/COL10A1/SLC6A19/ATP1A1/COL23A1/SLC38A2/SLC7A8/CELA3A/COL18A1/XPNPEP2/COL6A2/COL26A1/SLC1A1/PGA3/PGA4/PGA5/PRSS2/CTRB1/COL28A1/COL24A1/KCNQ1/ATP1A2/COL15A1/COL9A2/COL16A1/COL7A1/COL21A1/MEP1A/PRSS1/COL27A1/SLC15A1/DPP4/KCNK5/CPA2/ACE2/SLC1A5/SLC36A4/MEP1B/CPB2	73
KEGG	hsa00860	Porphyrin metabolism	30/5985	43/8135	0.7741	0.8261	0.5649	BLVRB/ALAS2/UGT1A10/UGT1A4/UGT1A6/HMBS/UGT1A1/UGT1A8/UGT1A9/CPOX/ALAS1/EARS2/GUSB/UGT2B15/HMOX2/HCCS/COX10/CP/UROD/FECH/UROS/MMAB/UGT1A3/UGT1A5/UGT2A3/UGT1A7/HMOX1/UGT2A1/UGT2A2/COX15	30
KEGG	hsa04975	Fat digestion and absorption	30/5985	43/8135	0.7741	0.8261	0.5649	DGAT2/ACAT1/CD36/AGPAT1/MOGAT2/PLA2G2D/SLC27A1/GOT2/APOA4/PLA2G1B/SCARB1/PLA2G2F/PLA2G2A/APOA1/PLA2G12A/MTTP/DGAT1/ABCA1/PLA2G2E/FABP2/ABCG8/SLC27A4/PLA2G12B/FABP1/PLA2G3/PNLIPRP1/MOGAT3/PLA2G10/PLA2G5/AGPAT2	30
KEGG	hsa04930	Type II diabetes mellitus	32/5985	46/8135	0.7868	0.8369	0.5724	SOCS4/SOCS3/HK1/MTOR/PKM/MAPK8/SOCS1/PDX1/MAPK9/IRS1/PIK3CB/HK3/INS/PRKCZ/PRKCD/ABCC8/CACNA1G/CACNA1A/PIK3CD/PIK3R3/CACNA1C/CACNA1D/PKLR/GCK/PIK3R2/MAPK1/PIK3CA/IRS2/MAPK3/HK2/CACNA1E/PRKCE	32
KEGG	hsa00592	alpha-Linolenic acid metabolism	17/5985	25/8135	0.8077	0.8564	0.5857	PLA2G2D/ACOX1/PLA2G1B/PLA2G4F/PLA2G2F/PLA2G2A/PLA2G4A/PLA2G12A/JMJD7-PLA2G4B/PLA2G2E/PLA2G12B/PLA2G3/PLA2G10/PLA2G6/PLA2G5/FADS2/PLB1	17
KEGG	hsa00730	Thiamine metabolism	10/5985	15/8135	0.8186	0.8652	0.5917	AK8/ALPP/AK7/AK4/ALPI/THTPA/ALPL/AK2/NFS1/ACP1	10
KEGG	hsa00230	Purine metabolism	90/5985	128/8135	0.8278	0.8722	0.5965	AK8/GMPR/ENTPD4/PDE4C/ENTPD6/AK9/GDA/NME6/ALLC/ADCY6/XDH/AK7/PDE7B/NUDT5/DCK/ENPP3/NME7/NT5C2/NT5M/PDE6G/ADCY7/PDE4D/IMPDH2/AK6/IMPDH1/PNP/PAPSS1/PGM1/HDDC3/AK4/PDE4A/RRM2B/PDE6A/CANT1/AK3/PAICS/NUDT2/ADCY9/NME3/ADCY8/PDE4B/HPRT1/ADSL/NPR1/PDE8B/GUCY1A2/PGM2/PDE5A/AMPD2/ATIC/GMPS/ITPA/ENTPD1/AMPD1/GMPR2/PDE6C/PRPS2/AK2/ADA/ENTPD5/ENTPD3/NT5C1B-RDH14/LACC1/FHIT/NT5C1B/PDE7A/PDE3A/GUCY2C/ADCY5/NT5C1A/PDE1C/GUCY2D/NUDT9/HDDC2/ENTPD2/PDE8A/PDE1B/PDE11A/PRPS1/APRT/AMPD3/PDE3B/GUK1/ADCY3/NT5C/PDE9A/NME4/PPAT/RRM2/PDE2A	90
KEGG	hsa00561	Glycerolipid metabolism	42/5985	61/8135	0.8379	0.8801	0.6019	GLYCTK/ALDH9A1/DGKE/ALDH1B1/MBOAT2/AGPAT4/DGAT2/MOGAT1/AGPAT5/AGPAT1/DGKA/PNPLA2/MOGAT2/LPIN2/DGKK/LCLAT1/MGLL/ALDH2/GLA/GPAM/AKR1A1/DGKG/GK/ALDH3A2/DGAT1/DGKZ/MBOAT1/ALDH7A1/PNLIPRP3/PNPLA3/DGKQ/GPAT2/PNLIPRP1/MOGAT3/LIPC/AKR1B1/DGKH/GK2/DGKB/AGPAT2/AKR1B10/LIPG	42
KEGG	hsa01212	Fatty acid metabolism	39/5985	57/8135	0.8496	0.8896	0.6084	ELOVL7/CPT1A/CPT2/HADHB/MECR/PPT1/ACSL1/HSD17B12/ACAT1/CBR4/ELOVL1/SCP2/ACOX1/ACADS/ACADM/CPT1B/ACSF3/HADH/CPT1C/ECHS1/FASN/ACSL6/OXSM/ELOVL2/ACSL4/ELOVL5/ACSBG2/TECR/ACSL3/ACADVL/ACACA/HSD17B8/EHHADH/HADHA/ACSBG1/ACADL/MCAT/FADS2/HSD17B4	39
KEGG	hsa00670	One carbon pool by folate	13/5985	20/8135	0.8682	0.9039	0.6182	MTHFD2/ALDH1L2/MTHFS/ST20-MTHFS/SHMT1/MTHFR/ATIC/FTCD/TYMS/MTHFD1L/ALDH1L1/MTR/SHMT2	13
KEGG	hsa04340	Hedgehog signaling pathway	38/5985	56/8135	0.8687	0.9039	0.6182	SMURF1/SPOP/FBXW11/SMO/GSK3B/CSNK1G2/CUL1/CUL3/MGRN1/CCND2/CDON/CSNK1G3/SHH/SUFU/EVC2/KIF7/PRKACA/HHATL/BCL2/BOC/BTRC/GLI3/CSNK1A1/HHIP/GLI1/GAS1/EVC/DISP1/MEGF8/PRKACB/SPOPL/ARRB2/PTCH2/PTCH1/IHH/HHAT/ARRB1/PRKACG	38
KEGG	hsa03450	Non-homologous end-joining	8/5985	13/8135	0.8993	0.9328	0.638	DCLRE1C/XRCC6/POLM/XRCC5/XRCC4/NHEJ1/PRKDC/DNTT	8
KEGG	hsa04217	Necroptosis	110/5985	159/8135	0.9112	0.9422	0.6444	JAK3/IFNA10/IFNA16/PGAM5/IFNA14/JAK1/TRADD/IFNA17/FADD/FAF1/XIAP/CHMP2A/CHMP4C/TNFSF10/IFNA13/CFLAR/CHMP3/RNF103-CHMP3/PYCARD/TICAM2/HSP90AB1/FTL/SHARPIN/TNFAIP3/PYGL/MAPK8/MLKL/TNFRSF10B/IFNGR2/STAT5B/SLC25A31/PARP1/TNFRSF1A/IFNA4/MAPK9/SLC25A4/BID/IFNA7/PLA2G4F/IFNGR1/FASLG/DNM1L/STAT2/CAMK2G/PPID/VPS4B/PPIA/IFNAR1/PLA2G4A/CAPN2/TLR4/SPATA2/SMPD1/BAX/RNF31/RIPK3/TRPM7/SLC25A6/HMGB1/CAPN1/RBCK1/STAT5A/IFNA1/GLUL/BCL2/CASP1/SLC25A5/JMJD7-PLA2G4B/VDAC1/CHMP6/IFNA5/STAT1/TRAF2/USP21/CYLD/IFNG/IL1B/HSP90AA1/TICAM1/TYK2/IFNA8/ALOX15/SPATA2L/IFNA6/SQSTM1/GLUD2/CHMP7/CAMK2D/EIF2AK2/IFNA21/STAT3/JAK2/IFNA2/FTH1/CHMP1A/AIFM1/IFNAR2/ZBP1/STAT4/VDAC2/GLUD1/IRF9/IL1A/PYGM/TNFRSF10A/CHMP4A/FAS/CAMK2B/VDAC3/BIRC3	110
KEGG	hsa05033	Nicotine addiction	26/5985	40/8135	0.9178	0.9461	0.6471	GABRG2/GABRA4/GRIN3A/GABRB3/SLC17A7/GRIN2B/CHRNA4/GABRE/CHRNB2/GRIN1/CACNA1A/SLC32A1/GABRB2/GRIN2A/GABRP/GABRQ/SLC17A8/GABRR1/GABRR2/GRIA4/SLC17A6/GRIN2C/GABRD/GRIA2/GABRA3/GRIN2D	26
KEGG	hsa00062	Fatty acid elongation	17/5985	27/8135	0.9253	0.9509	0.6503	ELOVL7/HADHB/MECR/PPT1/HSD17B12/ELOVL1/HADH/ECHS1/THEM5/ELOVL2/ELOVL5/ACOT4/TECR/ACOT1/ACOT2/ACOT7/HADHA	17
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	15/5985	27/8135	0.9875	1	0.6839	ELOVL7/BAAT/HSD17B12/ELOVL1/SCP2/ACOX1/ELOVL2/ELOVL5/ACOT4/TECR/ACOT1/ACOT2/ACOT7/FADS2/HSD17B4	15
KEGG	hsa03010	Ribosome	101/5985	158/8135	0.9973	1	0.6839	RPL27A/RPL38/RPLP2/RPS11/RPS27L/MRPS18C/MRPS15/RPL23/RPL39/RPL34/RPL10/RPL41/RPL36A/RSL24D1/MRPL34/UBA52/RPL22L1/RPL26L1/RPS3A/MRPL20/RPL37A/RPL21/RPL17/RPL17-C18orf32/RPS2/MRPS21/RPL36A-HNRNPH2/RPS7/MRPL22/MRPS12/RPL9/RPL18A/RPS25/MRPL1/RPL27/MRPL13/RPL24/RPL36AL/RPL30/RPLP1/MRPS10/MRPL24/RPL15/RPS17/RPL22/RPL7/MRPS11/RPS10-NUDT3/MRPL2/RPLP0/MRPL28/RPL35/RPL18/RPL13/FAU/MRPL35/RPS21/RPL6/RPS5/MRPL18/MRPL23/MRPS6/RPS9/MRPS14/RPL11/MRPS17/MRPS16/RPL5/RPL29/MRPL19/RPL7A/MRPL21/RPS19/RPS20/RPL35A/RPL23A/RPS4X/MRPL12/RPS15/RPS3/RPS13/RPS26/MRPS2/MRPL15/RPS14/RPL19/RPL28/RPS10/RPL10L/MRPL9/RPL31/RPS15A/RPS23/RPL3L/RPS29/MRPL30/RPS12/MRPL10/RPS27A/RPL12/RPS28	101
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	62/5985	109/8135	1	1	0.6839	UTP18/HEATR1/SNORD3A/SNORD3B-1/SNORD3B-2/SNORD3C/RPP25L/XRN1/SBDS/REXO1/CSNK2A1/AK6/UTP15/CSNK2B/GAR1/RPP40/POP1/MDN1/NOB1/XPO1/NOL6/TCOF1/UTP14C/RCL1/WDR43/POP4/NXF1/GNL3/NOP10/NXF2/NXF2B/GTPBP4/UTP6/EIF6/NHP2/GNL2/DKC1/IMP4/GNL3L/NMD3/NXT1/IMP3/WDR75/RBM28/NOP56/EMG1/NVL/FBLL1/UTP14A/PWP2/REXO2/NAT10/RIOK1/RPP38/POP5/CSNK2A2/RPP30/NXF3/TBL3/XRN2/LSG1/WDR3	62
KEGG	hsa04613	Neutrophil extracellular trap formation	101/5985	190/8135	1	1	0.6839	AKT2/ACTG1/HAT1/CYBA/HDAC3/AQP9/RAF1/FPR1/FPR2/VWF/SELP/ACTB/PLCB3/MTOR/NCF1/CAMP/HDAC8/ITGB3/FCGR3B/TLR8/TLR2/CR1L/MAP3K7/SLC25A31/NCF4/HDAC5/SYK/NCF2/SLC25A4/PIK3CB/FGG/TLR7/CASP4/TLR4/RAC1/ITGA2B/AGER/PRKCA/HDAC11/ATG7/SRC/C5AR1/HDAC4/CLCN4/FGA/FCGR3A/AKT3/CR1/SLC25A6/HMGB1/CLCN3/SELPLG/PIK3CD/CTSG/PLCB4/CASP1/HDAC10/SLC25A5/ITGAL/VDAC1/MAP2K2/SIGLEC9/PIK3R3/PADI4/PRKCG/AZU1/GP1BA/ITGAM/ITGB2/PLCG2/HDAC2/RAC2/HDAC9/FPR3/FCGR1A/PLCB2/HDAC7/PIK3R2/GSDMD/MAPK1/CLEC7A/PIK3CA/AKT1/FCGR2A/PPIF/C5/MAPK3/HDAC1/MAPK14/VDAC2/MAP2K1/ELANE/LOC102723407/MAPK13/FGB/NFKB1/HDAC6/CLCN5/PLCB1/VDAC3/MPO	101
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	20/5985	66/8135	1	1	0.6839	RARS2/PSTK/PARS2/EARS2/YARS2/SEPSECS/FARS2/TARS2/QRSL1/LARS2/HARS2/MARS2/NARS2/AARS2/VARS2/WARS2/CARS2/IARS2/FARSB/SARS2	20
KEGG	hsa05034	Alcoholism	88/5985	187/8135	1	1	0.6839	ATF6B/GNG2/HRAS/ARAF/SHC1/ATF2/KRAS/FOSB/GNG11/GNG4/BRAF/PPP1CC/HAT1/HDAC3/PPP1CB/RAF1/SLC18A2/CREB5/NRAS/SOS2/DRD2/GRIN3A/SLC6A3/GNB2/CREB3L3/HDAC8/CALM2/CALM3/GNG5/CREB3/CAMKK1/HDAC5/CREB3L4/GNG10/CALML5/CALML4/PPP1R1B/GNGT1/CALML3/CALML6/GRIN2B/GNG7/HDAC11/CALM1/GNG8/TH/PRKACA/HDAC4/ADORA2B/GRB2/SLC29A3/GRIN1/SLC29A2/CREB1/GRIN2A/DDC/GNG13/HDAC10/ADORA2A/SHC3/ATF4/BDNF/GNG3/NTRK2/HDAC2/HDAC9/PPP1CA/ADCY5/PKIA/GNAI2/PRKACB/CREB3L1/HDAC7/GNAI3/GRIN2C/MAPK1/GNG12/GRIN2D/MAPK3/HDAC1/GNAO1/MAP2K1/DRD1/SHC2/SOS1/GNB4/HDAC6/PRKACG	88
KEGG	hsa04740	Olfactory transduction	112/5985	440/8135	1	1	0.6839	OR1A1/OR51I2/OR51B2/OR5P2/OR7C2/OR5P3/OR7A5/OR51M1/OR51I1/OR4D2/OR6A2/OR51B6/OR2F1/OR2H1/SLC8A3/OR14J1/OR1I1/OR12D2/PRKG1/OR4F16/OR4F21/OR4F29/OR4F3/OR10A5/OR51B4/OR51B5/OR51E1/OR1D2/OR3A1/OR10H3/CALM2/CALM3/OR2C1/OR8D1/OR1A2/OR6B1/OR12D3/OR1E1/OR51J1/OR8D2/CALML5/OR5I1/OR2S2/OR2B6/OR1G1/CALML4/OR13C4/OR2K2/OR2F2/OR8G1/OR2M4/CAMK2G/CALML3/CALML6/GNG7/OR51E2/CALM1/OR5V1/LOC102723532/GNAL/OR2B3/OR7E24/OR10J1/PRKACA/SLC8A2/OR2J2/OR1D5/SLC24A4/OR52A1/RGS2/OR2H2/OR10D3/OR7A17/GNG13/OR2L2/OR11A1/OR8B2/OR7C1/OR1E2/OR10H2/CNGA4/OR1J2/OR5K1/OR5L2/OR3A2/OR7D2/OR8B8/OR7A10/CNGB1/OR4N4/OR2J3/OR10A3/PDE1C/CAMK2D/PRKACB/GUCY2D/OR5J2/ARRB2/ANO2/OR1F1/OR10C1/OR1C1/PDE1B/OR1Q1/OR2W1/OR10H1/OR2L13/ADCY3/ARRB1/CAMK2B/PRKACG/PDE2A	112
KEGG	hsa05206	MicroRNAs in cancer	145/5985	310/8135	1	1	0.6839	TP53/DICER1/GLS/MCL1/MDM4/HRAS/SHC1/ABCC1/MDM2/MIR195/EGFR/KRAS/MIR124-1/CDK6/RPS6KA5/TNN/MIR29A/MIR29B1/MIR145/EZR/TPM1/RAF1/CDKN1B/DDIT4/MMP9/EFNA1/NRAS/SOS2/FGFR3/MIR17/MIR18A/MIR19A/MIR19B1/MIR20A/MIR92A1/RDX/CYP1B1/BRCA1/MTOR/BCL2L11/SLC45A3/GLS2/MIR21/ITGB3/PDCD4/PAK4/CD44/ROCK1/SOCS1/SLC7A1/CCND2/ITGA5/EZH2/CREBBP/CCNG1/CCNE2/HDAC5/IGF2BP1/PDGFA/IRS1/CRK/PIK3CB/ERBB2/MIR29B2/MIR29C/APC/APC2/PRKCA/MET/MIR34A/HDAC4/RPTOR/MIR224/GRB2/FZD3/ATM/KIF23/TP63/SIRT1/E2F3/WNT3/MAPK7/PDGFRA/PIK3CD/TNR/BCL2/RHOA/PIM1/MAP2K2/ST14/EP300/PIK3R3/PRKCG/RECK/PTEN/NOTCH1/MIR101-1/MARCKS/EFNA3/MIR205/DNMT3B/PLCG2/ZEB2/DNMT1/HDAC2/MIR10A/HOXD10/SOX4/NOTCH2/MIR155/PTGS2/DNMT3A/SERPINB5/PIK3R2/STAT3/STMN1/HMOX1/NOTCH4/MAPK1/PIK3CA/ERBB3/UBE2I/IRS2/VIM/CDKN1A/MIR23A/MAPK3/HDAC1/ABL1/CDC25A/MAP2K1/MIR146A/PRKCE/THBS1/NOTCH3/BAK1/TRIM71/ZFPM2/CCNE1/CDKN2A/SOS1/NFKB1/FSCN1/BCL2L2/EFNA4	145
KEGG	hsa05322	Systemic lupus erythematosus	44/5985	136/8135	1	1	0.6839	C7/C8G/SNRPD1/SNRPB/ACTN4/SSB/C4A/C4B/FCGR3B/ACTN1/C6/CD80/HLA-DPA1/GRIN2B/HLA-DMB/FCGR3A/HLA-DRB1/CD40/HLA-DQA2/HLA-DRA/CD86/HLA-DMA/CD40LG/GRIN2A/CTSG/HLA-DQB1/TRIM21/IL10/C8B/HLA-DOB/HLA-DRB4/IFNG/HLA-DOA/C8A/FCGR1A/C1QC/HLA-DPB1/C2/FCGR2A/C5/ELANE/HLA-DQA1/LOC102723407/CD28	44