ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05168	Herpes simplex virus 1 infection	290/3397	495/8135	5.737e-15	1.916e-12	1.359e-12	MYD88/TLR2/ZNF813/ZNF302/ZNF420/ZNF589/SOCS3/ZNF566/ZNF112/ZNF564/IRF7/ZNF546/TSC1/NXF1/ITGA5/SRSF5/ZNF570/ZNF84/ZNF223/TNFRSF14/ZNF234/ZNF606/ZNF616/ZNF320/ZNF765/TAP2/ZNF780A/ZNF34/BIRC2/TAP1/STAT1/ZNF253/ZNF331/ZNF571/ZNF763/ZNF250/ZNF615/JAK2/ZNF227/ZNF850/IFNAR1/FAS/ZNF347/ZNF230/ZNF585A/TNF/ZNF304/CD74/NFKBIA/ZNF382/ZNF383/ZNF180/PDIA3/NFKB1/ZNF132/ZNF222/ZNF284/ZNF14/ZNF256/ZNF398/ALYREF/PIK3R3/ZFP82/TICAM1/ZNF879/ZNF552/POU2F1/ZNF184/ZFP30/RELA/ZNF677/IFNGR2/ZNF268/ZNF623/ZNF529/IRAK4/ZNF33B/ZNF630/ZNF600/ZNF746/ZNF225/ZNF573/ZNF416/ZNF557/ZNF627/ZNF658/POU2F2/ZNF91/ZNF569/IRF9/ZNF624/ZNF597/ZNF74/CFP/HLA-F/ZNF141/ZNF567/TRAF6/IKBKG/ZNF766/ZNF212/ZNF585B/ZFP28/ZNF717/EIF2B5/ZNF419/DDX58/RBAK/ZFP14/ZNF671/TRAF3/HLA-DPB1/ZNF248/OAS3/HLA-DPA1/ZNF2/ZNF226/ZNF480/HLA-E/HLA-B/CASP3/ZNF33A/SP100/ZNF780B/ZNF317/ZNF670/CASP8/ZNF30/IL1B/CCL5/ZNF605/ZNF550/PML/SRSF3/OAS2/HLA-DMB/ZNF79/ZNF547/ZNF19/ZNF135/TRADD/ZNF544/ZNF267/ZNF554/HLA-DOB/ZNF441/HLA-G/ZNF43/EIF2S1/ZNF182/MAVS/IL6/HLA-DRA/ZNF610/ZNF41/ZNF565/ZNF431/ZNF785/ZNF700/TAPBP/ZNF224/HLA-DMA/ZNF559/HLA-C/ZNF101/ZNF528/ZNF235/ZFP92/ZNF140/ZNF83/ZNF254/ZIK1/ZNF442/ZNF354C/ZNF286A/IFIH1/ZNF823/ZNF100/TAB1/BCL2/ZNF136/BAX/ZNF777/PIK3CD/ZNF189/TYK2/SRSF6/BIRC3/ZNF343/SRSF7/ZNF649/ZNF57/ZNF12/RNASEL/ZFP90/ZNF808/PILRA/ZNF519/ZNF680/SRPK1/ZNF468/ZNF792/ZNF124/ZNF221/ZNF621/CALR/ZNF114/ZNF701/ZNF283/ZNF684/ZNF10/PPP1CC/PPP1CA/IFNGR1/EIF2AK2/ZNF324/FADD/TRAF2/ZNF133/ZNF211/ZNF169/ZNF551/ZNF200/ZNF782/ZNF282/ZNF665/EIF2AK1/ZNF568/ZNF514/BAD/EIF2B1/SRSF4/ZNF471/TRAF5/HLA-A/ZNF718/IFNG/JAK1/ZNF669/ZNF510/PPP1CB/ZNF611/EIF2B3/TLR3/ZNF786/ZNF418/ZNF708/IFNAR2/ZNF300/IL12B/ZNF582/ZNF709/ZNF689/EIF2AK4/ZNF436/ZNF85/ZNF26/ZNF404/ZNF749/ZNF23/ZNF8/MTOR/ZNF577/ZNF829/ZNF583/ZNF3/ZNF527/ZNF791/ZNF429/ZNF713/ZNF530/BAK1/CHUK/ZFP69B/EIF2B2/ZNF891/ZNF311/DAXX/ZNF426/HLA-DOA/ZNF558/ZNF473/ZNF562/ZNF460/PIK3CB/ZNF563/ZNF275/ZNF607/ZNF44/ZNF354B	290
KEGG	hsa04380	Osteoclast differentiation	86/3397	128/8135	4.368e-09	7.294e-07	5.172e-07	JUNB/FOS/FYN/LILRB2/LILRA3/ACP5/MAPK12/SPI1/SOCS3/FCGR1A/FOSB/JUND/LILRA5/LILRA1/LILRB3/FCGR3B/MAP2K1/STAT1/SQSTM1/LILRA2/LILRA6/CTSK/IFNAR1/TNF/NFKBIA/NFKB1/LILRB1/PIK3R3/LCP2/RELA/IFNGR2/TGFB1/PPP3CB/LILRB5/IRF9/NCF4/MAPK13/OSCAR/LILRB4/TRAF6/NFKB2/NCF2/IKBKG/NCF1/FCGR2C/RELB/IL1B/SIRPB1/PLCG2/MITF/TNFRSF11A/CREB1/TYROBP/BLNK/IL1R1/RAC1/LCK/CYLD/MAPK8/TAB1/NFATC1/NFATC2/PIK3CD/TYK2/TEC/IL1A/GRB2/CYBA/IFNGR1/TRAF2/FHL2/MAPK1/FOSL2/SOCS1/SIRPG/TREM2/FOSL1/IFNG/JAK1/MAPK11/FCGR2A/IFNAR2/CSF1R/CHUK/PIK3CB/MAPK9	86
KEGG	hsa04142	Lysosome	87/3397	132/8135	1.47e-08	1.637e-06	1.161e-06	FUCA1/ATP6V0D2/ASAH1/HEXB/ACP5/CTSA/SLC11A1/GNPTG/MCOLN1/MANBA/CTSF/ATP6AP1/TPP1/CTSD/NAGLU/DMXL1/GM2A/GGA2/NPC2/AP1B1/LIPA/CTSS/CTSC/IDS/LGMN/LAMP2/SUMF1/CTSK/LAMP3/PSAP/LAMP1/WDR7/ATP6V0C/DNASE2B/HEXA/M6PR/ARSB/SGSH/GALC/MAN2B1/NAGPA/CD63/GNPTAB/HYAL2/TCIRG1/AP3M2/GNS/IGF2R/CTSZ/CLTB/NCOA7/PLA2G15/CLN3/CTSB/AGA/GLA/IDUA/AP1M2/AP1G2/CLTCL1/GUSB/MFSD8/AP4S1/NAGA/CTSV/CLN5/HYAL3/CTSE/SLC17A5/AP4B1/LAPTM4B/AP1S3/AP3B1/ARSA/AP1G1/GAA/FUCA2/CTSW/NEU1/AP3M1/AP1M1/SMPD1/CTSG/CTSO/CTNS/DNASE2/DMXL2	87
KEGG	hsa05169	Epstein-Barr virus infection	123/3397	202/8135	2.312e-08	1.93e-06	1.369e-06	MYD88/TLR2/CDKN1A/MAPK12/LYN/IRF7/RBPJ/CD58/STAT3/CCND3/VIM/TNFAIP3/CD40/TAP2/TAP1/STAT1/CD44/MYC/IFNAR1/FAS/TNF/PSMD11/NFKBIA/CXCL10/PDIA3/SKP2/NFKB1/PIK3R3/CCND2/ENTPD1/RELA/CDK4/IRAK4/GADD45B/SIN3A/IRF9/ITGAL/MAPK13/HLA-F/TRAF6/NFKB2/IKBKG/DDX58/TRAF3/HLA-DPB1/OAS3/HLA-DPA1/HLA-E/HLA-B/CASP3/RELB/NFKBIB/CASP8/PSMC4/CD3D/PLCG2/ADRM1/OAS2/HLA-DMB/PSMD13/ISG15/TRADD/BLNK/CCND1/HLA-DOB/HLA-G/RAC1/MAVS/IL6/HLA-DRA/TAPBP/HLA-DMA/HLA-C/PSMD6/PSMC3/HDAC2/BCL2L11/MAPK8/TAB1/FCER2/CCNE1/BCL2/NEDD4/BAX/CD247/PSMC6/PIK3CD/CDKN1B/TYK2/RBPJL/CR2/CD3G/NFKBIE/HES1/CALR/EIF2AK2/FADD/TRAF2/USP7/MDM2/CCNA1/DDB2/PSMC1/MAP2K4/PSMD8/TRAF5/HLA-A/JAK1/MAPK11/RB1/CCNA2/IFNAR2/PSMC5/PSMC2/PSMD4/BAK1/CHUK/PSMD1/CD3E/PSMD3/HLA-DOA/PIK3CB/MAPK9	123
KEGG	hsa05132	Salmonella infection	145/3397	249/8135	7.866e-08	5.254e-06	3.726e-06	MYD88/S100A10/FOS/TLR2/RAB9A/TUBA1A/MAPK12/MYL12A/ARF6/FHOD1/CYTH4/GAPDH/KLC1/NLRP3/TNFRSF10A/TUBB6/FLNA/DYNC1LI1/MAP2K1/BIRC2/LY96/MYC/CYTH1/PTPRC/RRAS/TNF/NFKBIA/PLEKHM2/NFKB1/ACTR2/M6PR/VPS41/RELA/TUBB2A/ACTB/IRAK4/PFN1/PAK1/TLR5/DYNLL2/TAB3/MAPK13/TRAF6/RHOG/IKBKG/KPNA4/AHNAK/SNX18/TLR4/CASP3/HRAS/CYFIP2/TNFSF10/TUBB3/CASP8/IL1B/ARPC1A/VPS33A/CASP5/TRADD/RAF1/CASP7/RAC1/PLEKHM1/ARPC1B/IL6/SNX33/CYFIP1/TCF7L1/ARF1/ARPC5L/ARL8A/MAPK8/TAB1/VPS18/BCL2/DNM2/TUBA1C/BAX/RAB5C/PIK3CD/BIRC3/DCTN2/RAB5A/CSE1L/ACBD3/DYNC2LI1/CASP1/TUBA4A/MLKL/MAP2K2/ACTR3B/RAB7B/DYNLRB1/DYNLRB2/ACTR3/RHOH/ELMO1/TNFRSF10B/MYL5/FLNB/DYNLT3/MYL12B/TXN/IL18/FADD/TRAF2/HSP90B1/CASP4/TUBB4A/MAPK1/TUBAL3/TCF7L2/KPNA1/MAP2K4/TUBB1/ARPC4/TUBA1B/EXOC4/MAPK11/KIF5B/KLC4/HSP90AB1/PIK3CG/VPS16/DYNC1LI2/KLC2/ARPC2/ANXA2/RHOA/SNX9/TIRAP/BAK1/CHUK/DCTN6/ROCK2/DCTN5/KLC3/TLR6/NCKAP1/EXOC2/ELMO2/ARL8B/PIK3CB/MAPK9	145
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	130/3397	222/8135	2.398e-07	1.262e-05	8.946e-06	FOS/IL2RG/IL1R2/CDKN1A/SPI1/ZFP36/CCND3/CD40/MAP2K1/SMAD2/MYC/IL15/EGR1/TNF/PRKACB/NFKBIA/NFKB1/RAN/KRAS/PIK3R3/CCND2/KAT2B/ATF4/RELA/CDK4/TLN1/TGFB1/PPP3CB/CREB5/NFATC3/ITGAL/SRF/HLA-F/NFKB2/IKBKG/HLA-DPB1/IL2RB/HLA-DPA1/HLA-E/HLA-B/CDKN2B/ETS2/HRAS/RELB/STAT5A/CREB3L2/CD3D/FDPS/HLA-DMB/CRTC2/CREB1/CCND1/IL1R1/HLA-DOB/HLA-G/EGR2/ADCY7/IL6/LCK/HLA-DRA/SLC25A5/CDC23/CREB3L4/ESPL1/CRTC1/HLA-DMA/ADCY1/HLA-C/ETS1/ATM/ANAPC5/CRTC3/BUB3/IL15RA/KAT5/MAPK8/NRP1/CCNE1/ADCY3/NFATC1/BAX/NFATC2/ANAPC7/PIK3CD/CDKN2C/TLN2/PRKACA/NRAS/CREB3/CD3G/MAP2K2/VDAC2/CANX/CALR/VDAC1/CDC26/TBPL1/ATR/ELK4/KAT2A/CCNA1/MAPK1/MAP2K4/ANAPC4/TGFB3/HLA-A/FOSL1/CDC27/JAK1/CDC20/MAP3K1/CD4/RB1/CCNA2/TNFRSF13C/MSX1/TERT/POLB/TBP/VDAC3/ANAPC11/VAC14/ANAPC13/CHUK/XIAP/CD3E/HLA-DOA/ATF6B/PIK3CB/MAPK9	130
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	61/3397	89/8135	2.644e-07	1.262e-05	8.946e-06	MYD88/FOS/TLR2/PTPN6/MAPK12/STAT3/BATF3/MAP2K1/STAT1/EML4/JAK2/ALK/BATF/NFKBIA/NFKB1/KRAS/PIK3R3/TICAM1/RELA/IFNGR2/CSNK2A2/PPP3CB/NFATC3/HIF1A/MAPK13/TRAF6/IKBKG/TLR4/HRAS/NFKBIB/CD3D/RASGRP1/CSNK2B/RAF1/LCK/BATF2/NFATC1/CD247/NFATC2/PIK3CD/NRAS/CD3G/MAP2K2/CD274/NFKBIE/IFNGR1/EGFR/MAPK1/IFNG/JAK1/MAPK11/RPS6KB2/CD4/MTOR/PRKCQ/TIRAP/CHUK/CD3E/PDCD1/LAT/PIK3CB	61
KEGG	hsa04210	Apoptosis	84/3397	136/8135	1.702e-06	7.107e-05	5.039e-05	FOS/LMNB1/TUBA1A/AIFM1/LMNA/CTSF/CAPN2/CTSD/TNFRSF10A/PMAIP1/BCL2A1/CTSS/MAP2K1/BIRC2/CASP6/CTSC/CTSK/FAS/TNF/NFKBIA/NFKB1/KRAS/PIK3R3/PTPN13/ATF4/RELA/ACTB/GADD45B/CSF2RB/ITPR1/IL3RA/IKBKG/MCL1/HTRA2/PARP2/CASP3/HRAS/TNFSF10/CTSZ/CASP8/DFFA/CTSB/TRADD/RAF1/CASP7/EIF2S1/ATM/BCL2L11/MAPK8/BCL2/TUBA1C/PARP3/BAX/PIK3CD/CASP2/GZMB/BIRC3/NRAS/TUBA4A/MAP2K2/CTSV/MAP3K5/TRAF1/TNFRSF10B/FADD/TRAF2/PRF1/MAPK1/TUBAL3/BAD/TUBA1B/IL3/CTSW/SPTA1/DIABLO/ERN1/CTSO/BAK1/CHUK/XIAP/ENDOG/DAXX/PIK3CB/MAPK9	84
KEGG	hsa05140	Leishmaniasis	50/3397	77/8135	3.194e-05	0.001185	0.0008404	MYD88/ITGAM/FOS/TLR2/PTPN6/MAPK12/FCGR1A/MARCKSL1/PTGS2/FCGR3B/STAT1/JAK2/TNF/NFKBIA/NFKB1/RELA/IFNGR2/IRAK4/TGFB1/NCF4/MAPK13/TRAF6/NCF2/ITGA4/NCF1/TLR4/HLA-DPB1/HLA-DPA1/FCGR2C/NFKBIB/IL1B/HLA-DMB/HLA-DOB/HLA-DRA/CR1/HLA-DMA/TAB1/IL1A/CYBA/CYBB/EEF1A2/IFNGR1/MAPK1/TGFB3/IFNG/JAK1/MAPK11/FCGR2A/IL12B/HLA-DOA	50
KEGG	hsa04145	Phagosome	88/3397	152/8135	3.812e-05	0.001273	0.0009029	ITGAM/ATP6V0D2/TLR2/TUBA1A/CLEC7A/STX7/FCGR1A/OLR1/ITGA5/ATP6AP1/MRC2/ITGB5/MARCO/TUBB6/ATP6V1C1/FCGR3B/TAP2/DYNC1LI1/CTSS/TAP1/SEC22B/LAMP2/SCARB1/LAMP1/ATP6V0C/THBS3/FCAR/M6PR/TUBB2A/ACTB/SEC61B/CD36/NCF4/HLA-F/CORO1A/NCF2/TCIRG1/NCF1/TLR4/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/CD209/VAMP3/FCGR2C/ATP6V1A/TUBB3/HLA-DMB/ATP6V1G3/HLA-DOB/HLA-G/RAC1/ATP6V1B2/HLA-DRA/HLA-DMA/HLA-C/ATP6V1D/TUBA1C/ATP6V0E2/RAB5C/RAB5A/ITGA2/TUBA4A/HGS/CYBA/CYBB/C1R/RAB7B/ATP6V1G2/CANX/STX18/CALR/TFRC/TUBB4A/SEC61G/TUBAL3/STX12/TUBB1/TUBA1B/HLA-A/FCGR2A/DYNC1LI2/ATP6V1B1/SEC61A2/MPO/TLR6/HLA-DOA	88
KEGG	hsa04141	Protein processing in endoplasmic reticulum	97/3397	171/8135	4.804e-05	0.001459	0.001034	HSPA6/ERP29/DAD1/CAPN2/PPP1R15A/CKAP4/CUL1/MAN1C1/FBXO6/BCAP31/RAD23B/PDIA3/PLAA/SSR4/ATF4/EDEM1/UBE4B/SEC62/DNAJB1/SAR1B/WFS1/SEC61B/STT3A/UBE2D3/SSR1/UBE2D2/HSPA5/NSFL1C/UBE2J1/EIF2S1/DNAJC5B/UBE2G2/EDEM2/DNAJC1/HSPBP1/SAR1A/RPN2/PDIA6/UBXN8/NPLOC4/MAPK8/STT3B/UBQLN2/BCL2/BAX/UBE2D4/MAN1B1/GANAB/DNAJC10/DERL1/LMAN1/NGLY1/MAP3K5/CANX/DERL2/STUB1/CALR/HSPA1L/NFE2L2/ATXN3/MAN1A2/MOGS/TUSC3/EIF2AK2/YOD1/TRAF2/BAG2/HSP90B1/RRBP1/SEC61G/EIF2AK1/UBXN1/DNAJA1/HYOU1/RNF185/HSP90AB1/RNF5/UBE2G1/EIF2AK4/VCP/MBTPS2/ERN1/RBX1/BAK1/MBTPS1/EDEM3/SEC61A2/ATXN3L/PREB/SEC24A/DDOST/TRAM1/ERLEC1/OS9/ATF6B/SEC31B/MAPK9	97
KEGG	hsa04146	Peroxisome	52/3397	82/8135	5.81e-05	0.001617	0.001147	PEX11A/SOD1/FAR2/HMGCL/PEX12/ACAA1/ABCD4/ACSL5/PHYH/PEX11G/SCP2/MPV17/PEX16/ABCD3/PRDX1/ECH1/MPV17L/ACSL4/CAT/AGPS/ACOX1/ECI2/SLC27A2/HSD17B4/IDH1/ACOX2/DAO/DECR2/MLYCD/IDH2/PXMP4/ACSL6/PXMP2/NUDT19/PEX13/PEX3/PEX19/EHHADH/FAR1/NUDT7/PEX14/PEX11B/ACOX3/GNPAT/CROT/ABCD1/MPV17L2/HMGCLL1/HACL1/HAO1/ACOT8/PIPOX	52
KEGG	hsa04659	Th17 cell differentiation	65/3397	108/8135	7.865e-05	0.002021	0.001433	FOS/IL2RG/IL27RA/MAPK12/STAT6/STAT3/STAT1/SMAD2/IL4R/JAK2/NFKBIA/NFKB1/IL1RAP/RELA/IL21R/IFNGR2/TGFB1/PPP3CB/NFATC3/HIF1A/MAPK13/IKBKG/HLA-DPB1/IL2RB/HLA-DPA1/NFKBIB/STAT5A/IL1B/CD3D/AHR/HLA-DMB/IL6ST/IL1R1/HLA-DOB/IL6/LCK/HLA-DRA/HLA-DMA/RXRA/MAPK8/NFATC1/CD247/NFATC2/TYK2/CD3G/IL12RB1/EBI3/NFKBIE/IFNGR1/MAPK1/RORA/IFNG/JAK1/MAPK11/CD4/HSP90AB1/TBX21/MTOR/PRKCQ/CHUK/CD3E/IL23A/HLA-DOA/LAT/MAPK9	65
KEGG	hsa05203	Viral carcinogenesis	111/3397	204/8135	0.0001521	0.00363	0.002574	ATP6V0D2/CDKN1A/LYN/IRF7/RBPJ/EGR3/STAT3/CCND3/PMAIP1/ACTN4/YWHAH/PRKACB/NFKBIA/SKP2/NFKB1/KRAS/PIK3R3/CCND2/KAT2B/REL/ATF4/PKM/RELA/SND1/UBE3A/CDK4/CREB5/IRF9/SRF/ACTN1/HLA-F/HNRNPK/NFKB2/IKBKG/DDB1/GTF2E1/TRAF3/HLA-E/HLA-B/RASA2/CDKN2B/CASP3/HRAS/SP100/CASP8/STAT5A/CREB3L2/HDAC11/CREB1/TRADD/IL6ST/CCND1/HLA-G/RAC1/EGR2/CCR5/CREB3L4/HLA-C/DDX3X/GTF2H4/HDAC10/HDAC2/HDAC7/CCNE1/MAPKAPK2/BAX/HDAC4/PIK3CD/CDKN1B/PRKACA/NRAS/RBPJL/CREB3/CCR4/GRB2/YWHAQ/TRAF1/PXN/CCR3/EIF2AK2/TBPL1/TRAF2/SCIN/USP7/KAT2A/GTF2A1/MDM2/CCNA1/MAPK1/YWHAE/PSMC1/BAD/RBL2/TRAF5/HLA-A/JAK1/MRPS18B/CDC20/RB1/CCNA2/YWHAG/POLB/TBP/VDAC3/HDAC5/HPN/RHOA/VAC14/BAK1/ATF6B/PIK3CB	111
KEGG	hsa05221	Acute myeloid leukemia	43/3397	67/8135	0.0001684	0.003749	0.002659	ITGAM/SPI1/DUSP6/FCGR1A/STAT3/PIM1/PPARD/BCL2A1/MAP2K1/MYC/PER2/NFKB1/KRAS/PIK3R3/RELA/IKBKG/FLT3/CEBPA/HRAS/STAT5A/ARAF/PML/RAF1/CCND1/TCF7L1/PIK3CD/NRAS/MAP2K2/GRB2/CCNA1/MAPK1/TCF7L2/BAD/IL3/RPS6KB2/CCNA2/CSF1R/MTOR/PIM2/CHUK/ZBTB16/MPO/PIK3CB	43
KEGG	hsa04140	Autophagy - animal	80/3397	141/8135	0.000213	0.004447	0.003153	ATG4C/ATG7/PPP2CA/ATG3/TSC1/C9orf72/CTSD/MAP2K1/ULK2/ATG14/SQSTM1/LAMP2/RRAS/LAMP1/PRKACB/KRAS/PIK3R3/ITPR1/HIF1A/MAP1LC3A/ATG101/PRKCD/TRAF6/TP53INP2/IGF1R/HRAS/CTSB/DAPK1/RRAGD/ATG13/HMGB1/WIPI1/RAB8A/RAF1/EIF2S1/RAB33B/IRS2/MLST8/MAP1LC3C/ATG9A/ZFYVE1/MAPK8/BCL2/MTMR4/ATG4B/RAB39B/PIK3CD/PRKACA/NRAS/ATG2B/MAP2K2/AKT1S1/DDIT4/RAB7B/RRAGA/ULK1/DEPTOR/PRKAA1/MAPK1/MTMR3/SH3GLB1/SMCR8/BAD/ATG16L2/IGBP1/RPS6KB2/GABARAPL1/ATG4D/ATG4A/EIF2AK4/SNAP29/MTOR/PRKCQ/ERN1/DAPK2/NRBF2/SUPT20H/PIK3CB/ATG12/MAPK9	80
KEGG	hsa04662	B cell receptor signaling pathway	50/3397	82/8135	0.0003294	0.006472	0.004589	FOS/RAC2/PTPN6/LILRB2/LILRA3/BCL10/LYN/CD72/LILRA5/LILRA1/LILRB3/MAP2K1/RASGRP3/LILRA2/LILRA6/IFITM1/NFKBIA/NFKB1/KRAS/GSK3B/LILRB1/PIK3R3/CD22/RELA/PPP3CB/NFATC3/LILRB5/LILRB4/DAPP1/IKBKG/HRAS/NFKBIB/PLCG2/RAF1/BLNK/RAC1/NFATC1/NFATC2/PIK3CD/NRAS/CR2/MAP2K2/GRB2/NFKBIE/VAV1/MAPK1/MALT1/CHUK/INPPL1/PIK3CB	50
KEGG	hsa03050	Proteasome	31/3397	46/8135	0.0003838	0.006976	0.004947	PSMB9/PSMB8/PSMA5/PSMD11/PSME1/PSMB10/PSMA1/PSMA4/PSMB1/PSMC4/ADRM1/PSMD13/PSMB3/PSMB5/PSMD6/PSMC3/PSME3/PSMC6/POMP/PSMC1/PSMD8/PSMA2/IFNG/PSMC5/PSMC2/PSMB2/PSMD4/PSMD1/PSMB4/PSMD9/PSMD3	31
KEGG	hsa05135	Yersinia infection	77/3397	137/8135	0.0004135	0.006976	0.004947	MYD88/FOS/RPS6KA2/FN1/RAC2/MAPK12/ARF6/ITGA5/NLRP3/RPS6KA3/MAP2K1/TNF/NFKBIA/NFKB1/GSK3B/ACTR2/PIK3R3/TICAM1/LCP2/RELA/ACTB/IRAK4/NFATC3/GNAQ/PTK2B/MAPK13/TRAF6/RHOG/IKBKG/BAIAP2/ITGA4/TLR4/IL1B/ARPC1A/CRK/RAC1/ARPC1B/IL6/LCK/PTK2/ARPC5L/MAPK8/TAB1/WIPF2/MEFV/NFATC1/NFATC2/PIK3CD/CASP1/MAP2K2/ACTR3B/ACTR3/ELMO1/PXN/VAV1/IL18/PKN2/TRAF2/MAPK1/MAP2K4/ARPC4/MAPK11/CD4/FCGR2A/WIPF1/ARPC2/PIP5K1B/RHOA/CHUK/CD8A/WAS/ROCK2/SKAP2/LAT/ELMO2/PIK3CB/MAPK9	77
KEGG	hsa00280	Valine, leucine and isoleucine degradation	32/3397	48/8135	0.0004178	0.006976	0.004947	ALDH3A2/HADHB/HIBADH/ALDH9A1/IL4I1/HADH/HMGCL/ACAA1/ALDH7A1/ALDH6A1/AACS/HMGCS1/AUH/ACADM/DBT/ACADS/MCEE/ALDH2/ACADSB/MCCC1/OXCT1/PCCB/HSD17B10/EHHADH/HADHA/AGXT2/ACAA2/BCKDHB/BCAT2/BCKDHA/HMGCLL1/AOX1	32
KEGG	hsa00030	Pentose phosphate pathway	22/3397	30/8135	0.0004506	0.007063	0.005008	TALDO1/FBP1/PFKM/PFKP/RPE/TKT/ALDOC/RPIA/ALDOA/GPI/G6PD/PGM2/DERA/PRPS1/TKTL2/PRPS1L1/PGD/PRPS2/GLYCTK/PFKL/PGLS/RBKS	22
KEGG	hsa04071	Sphingolipid signaling pathway	68/3397	119/8135	0.0004705	0.007063	0.005008	ASAH1/FYN/RAC2/S1PR4/SGMS2/MAPK12/PPP2CA/S1PR3/CTSD/GNAI3/S1PR1/MAP2K1/CERS2/DEGS1/TNF/NFKB1/KRAS/PIK3R3/PLD1/RELA/GNAQ/SGPL1/PPP2R3A/MAPK13/SGPP2/CERS5/SPTLC2/HRAS/TRADD/RAF1/RAC1/CERS4/PPP2R5C/SPHK1/FCER1A/MAPK8/BCL2/GNAI2/PPP2R2D/BAX/PPP2R2B/PIK3CD/SGMS1/NRAS/PPP2R3C/MAP2K2/MAP3K5/PLCB1/PPP2R1B/TRAF2/PLD2/MAPK1/GNA13/MAPK11/OPRD1/SMPD1/PPP2R5B/PRKCZ/RHOA/ADORA3/SMPD2/ROCK2/PRKCA/S1PR5/PPP2R2C/PIK3CB/DEGS2/MAPK9	68
KEGG	hsa04066	HIF-1 signaling pathway	63/3397	109/8135	0.0004941	0.007063	0.005008	IGF1/HK3/CDKN1A/LDHA/PGK1/FLT1/STAT3/PFKFB3/PFKM/PFKP/GAPDH/MAP2K1/HMOX1/NFKB1/PIK3R3/RELA/IFNGR2/HIF1A/INSR/ALDOC/TLR4/IGF1R/VEGFA/EGLN1/ENO1/ALDOA/PLCG2/EIF4E2/LDHB/IL6/EGLN3/LDHC/LDHAL6B/BCL2/SERPINE1/PIK3CD/CDKN1B/TIMP1/PDK1/MAP2K2/PDHB/CYBB/CAMK2A/PGK2/ARNT/CAMK2D/IFNGR1/EGFR/TFRC/PDHA2/MAPK1/ENO2/CUL2/MKNK2/EIF4E/IFNG/RPS6KB2/MTOR/RBX1/PFKL/PRKCA/PIK3CB/CAMK2B	63
KEGG	hsa04640	Hematopoietic cell lineage	58/3397	99/8135	0.0005075	0.007063	0.005008	ITGAM/IL1R2/CD55/FCGR1A/ITGA5/CD1C/KITLG/CD2/CD44/IL4R/CD1E/CD59/TNF/CD22/IL7R/CSF2RA/CD36/IL3RA/FLT3LG/ITGA4/FLT3/EPOR/HLA-DPB1/HLA-DPA1/IL1B/CD3D/CD1B/HLA-DMB/IL7/IL1R1/HLA-DOB/IL6/HLA-DRA/CR1/HLA-DMA/FCER2/MS4A1/IL1A/ITGA2/CR2/CD3G/CD1D/CD1A/ITGA3/TFRC/CD7/IL3/CD5/CSF3R/CD34/CD4/CD33/CSF1R/CD8A/CD3E/CD24/HLA-DOA/THPO	58
KEGG	hsa04660	T cell receptor signaling pathway	60/3397	104/8135	0.0007109	0.009439	0.006693	FOS/FYN/PTPN6/MAPK12/BCL10/MAP2K1/MAP3K8/PTPRC/TNF/NFKBIA/NFKB1/KRAS/GSK3B/PIK3R3/LCP2/RELA/CDK4/PPP3CB/NFATC3/CBLB/PAK1/MAPK13/IKBKG/NCK1/HRAS/NFKBIB/PAK2/CD3D/RASGRP1/RAF1/ITK/LCK/CTLA4/MAPK8/NFATC1/CD247/NFATC2/PIK3CD/NRAS/TEC/CD3G/MAP2K2/GRB2/ICOS/NFKBIE/VAV1/MAPK1/IFNG/MAPK11/CD4/PRKCQ/RHOA/MALT1/CHUK/CD8A/CD3E/PDCD1/LAT/PIK3CB/MAPK9	60
KEGG	hsa04658	Th1 and Th2 cell differentiation	54/3397	92/8135	0.0007348	0.009439	0.006693	FOS/IL2RG/DLL1/MAPK12/NOTCH2/RBPJ/STAT6/STAT1/IL4R/JAK2/NFKBIA/NFKB1/NOTCH3/RELA/IFNGR2/MAF/PPP3CB/NFATC3/MAPK13/IKBKG/HLA-DPB1/IL2RB/HLA-DPA1/NFKBIB/STAT5A/CD3D/HLA-DMB/HLA-DOB/LCK/HLA-DRA/HLA-DMA/MAPK8/NFATC1/CD247/NFATC2/TYK2/RBPJL/CD3G/IL12RB1/NFKBIE/IFNGR1/MAPK1/IFNG/JAK1/MAPK11/CD4/IL12B/TBX21/PRKCQ/CHUK/CD3E/HLA-DOA/LAT/MAPK9	54
KEGG	hsa01200	Carbon metabolism	65/3397	115/8135	0.0009254	0.01145	0.008118	TALDO1/HK3/FBP1/PGK1/MDH1/PFKM/PFKP/GAPDH/PSPH/ADH5/ME1/ALDH6A1/PGAM1/PKM/RPE/TPI1/TKT/ESD/ALDOC/ACADS/RPIA/CAT/ENO1/ALDOA/MCEE/ME3/ACOX1/OGDH/IDH1/ACO1/GPI/GLUD1/G6PD/IDH2/SHMT2/GLUD2/PCCB/FH/PRPS1/PDHB/GOT2/PGK2/SUCLG2/DLAT/SHMT1/IDH3A/AMT/PDHA2/ENO2/TKTL2/ACOX3/PRPS1L1/PGD/PRPS2/SDHA/PC/ADPGK/SDHD/ME2/IDH3G/GLYCTK/PFKL/PHGDH/HAO1/PGLS	65
KEGG	hsa04120	Ubiquitin mediated proteolysis	78/3397	142/8135	0.000964	0.0115	0.008154	TRIM32/KLHL13/SOCS3/WWP1/RHOBTB1/CUL1/KEAP1/BIRC2/SIAH1/FBXW7/UBE2Z/UBE2N/SKP2/UBE2Q2/UBE4B/TRIM37/UBE3A/UBE2K/CBLB/UBE2S/UBE2D3/TRAF6/DDB1/UBE2D2/UBE2L6/HERC2/UBR5/UBE2J1/UBE2W/PML/UBE2E1/UBE2A/UBE2F/UBE2G2/CDC23/RNF7/ANAPC5/KLHL9/UBA2/UBE2E2/NEDD4/UBE2D4/ANAPC7/BIRC3/UBC/DET1/UBE2C/BIRC7/STUB1/PIAS3/FANCL/FBXO4/CDC26/BRCA1/WWP2/UBE2M/MDM2/DDB2/SOCS1/CUL2/HERC4/ANAPC4/CDC27/CDC20/UBE2I/CUL4B/MAP3K1/PRPF19/UBE2G1/ANAPC11/RBX1/ANAPC13/XIAP/RHOBTB2/UBA1/UBE2B/UBE3B/ERCC8	78
KEGG	hsa05130	Pathogenic Escherichia coli infection	104/3397	197/8135	0.001021	0.01176	0.008337	MYD88/MYO1G/FOS/FYN/EZR/PTPN6/TUBA1A/MAPK12/ARF6/TMBIM6/CYTH4/GAPDH/NLRP3/TNFRSF10A/TUBB6/CYTH1/FAS/TNF/NFKBIA/NFKB1/ACTR2/RELA/TUBB2A/HCLS1/ACTB/IRAK4/LPAR5/PAK1/LPAR2/MYO5A/TLR5/TAB3/MAPK13/CLDN2/TRAF6/IKBKG/BAIAP2/TLR4/NCK1/CASP3/CYFIP2/ABL1/TNFSF10/NFKBIB/TUBB3/CASP8/CLDN7/PAK2/TMED10/IL1B/ARPC1A/ARHGEF2/TRADD/CASP7/IL1R1/RAC1/ARPC1B/IL6/CYFIP1/MYO1C/MYH9/ARF1/MYO5C/ARPC5L/MAPK8/TAB1/WIPF2/TUBA1C/BAX/CASP1/TUBA4A/ACTR3B/LPAR1/F2R/ACTR3/TNFRSF10B/CLDN23/IL18/FADD/TRAF2/CASP4/TUBB4A/MAPK1/GNA13/TUBAL3/TUBB1/ARPC4/TUBA1B/MYO10/MAPK11/CLDN18/FCGR2A/WIPF1/ARPC2/CLDN15/RHOA/TIRAP/BAK1/CHUK/ROCK2/SEC24A/NCKAP1/CLDN6/MAPK9	104
KEGG	hsa00510	N-Glycan biosynthesis	32/3397	50/8135	0.001213	0.01343	0.009521	MGAT2/DAD1/MGAT5/MAN1C1/MGAT4B/MAN2A2/STT3A/ALG2/ALG6/DPM1/RPN2/DOLK/STT3B/ALG12/ALG10/MGAT3/MAN1B1/GANAB/DOLPP1/MGAT5B/ALG13/MAN1A2/MOGS/TUSC3/SRD5A3/DPM3/B4GALT1/ALG14/DDOST/DPAGT1/ALG8/ALG3	32
KEGG	hsa05161	Hepatitis B	87/3397	162/8135	0.001299	0.01343	0.009521	MYD88/FOS/TLR2/CDKN1A/MAPK12/IRF7/EGR3/ATP6AP1/STAT6/STAT3/MAP2K1/STAT1/MYC/JAK2/IFNAR1/FAS/TNF/NFKBIA/NFKB1/KRAS/PIK3R3/TICAM1/ATF4/RELA/IRAK4/TGFB1/CREB5/NFATC3/PTK2B/MAPK13/TRAF6/IKBKG/DDB1/TLR4/DDX58/TRAF3/CASP3/HRAS/CASP8/STAT5A/CREB3L2/ARAF/CREB1/RAF1/MAVS/EGR2/IL6/CREB3L4/DDX3X/IFIH1/MAPK8/TAB1/MMP9/CCNE1/BCL2/PCNA/NFATC1/BAX/NFATC2/PIK3CD/TYK2/NRAS/CREB3/MAP2K2/GRB2/SLC10A1/YWHAQ/FADD/CCNA1/MAPK1/DDB2/MAP2K4/BAD/TGFB3/JAK1/MAPK11/MAP3K1/RB1/CCNA2/TLR3/VDAC3/TIRAP/CHUK/PRKCA/ATF6B/PIK3CB/MAPK9	87
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	102/3397	194/8135	0.001357	0.01343	0.009521	FOS/CDKN1A/MAPK12/LYN/IRF7/ZFP36/ATG3/STAT3/HCK/PTGS2/GNB1/GNB2/MAP2K1/STAT1/ATG14/MYC/GNG5/JAK2/IFNAR1/FAS/NFKBIA/NFKB1/KRAS/GSK3B/PIK3R3/TICAM1/RELA/GNG7/CDK4/PPP3CB/NFATC3/ITPR1/HIF1A/MAP1LC3A/IRF9/MAPK13/HLA-F/IKBKG/TRAF3/HLA-E/HLA-B/VEGFA/CASP3/HRAS/CASP8/PLCG2/PIK3R6/CREB1/TRADD/RAF1/IL6ST/CCND1/HLA-G/RAC1/IL6/PDGFB/CD200R1/GNG2/CLEC2B/MAP1LC3C/CCR5/TCF7L1/GNB3/HLA-C/MAPK8/MAPKAPK2/NFATC1/BAX/NFATC2/PIK3CD/TYK2/NRAS/RCAN1/UBC/CCR4/MAP2K2/GNB4/CCR3/IFNGR1/EIF2AK2/FADD/TRAF2/PREX1/CALML3/MAPK1/TCF7L2/MAP2K4/GNG11/HLA-A/JAK1/MAPK11/GNG12/RB1/TLR3/PIK3CG/IFNAR2/MICA/MTOR/BAK1/CHUK/PIK3CB/MAPK9	102
KEGG	hsa04064	NF-kappa B signaling pathway	59/3397	104/8135	0.001384	0.01343	0.009521	MYD88/BCL10/LYN/PTGS2/TNFAIP3/BCL2A1/CD40/BIRC2/LY96/TNF/NFKBIA/NFKB1/CXCL12/TICAM1/RELA/CSNK2A2/IRAK4/GADD45B/TNFSF13B/TAB3/TRAF6/NFKB2/IKBKG/TLR4/DDX58/TRAF3/CARD14/RELB/IL1B/PLCG2/CSNK2B/TNFRSF11A/TRADD/BLNK/IL1R1/LCK/CYLD/ATM/EDA/CCL13/TAB1/EDAR/BCL2/BIRC3/TRAF1/TRAF2/TRAF5/UBE2I/LBP/TNFRSF13C/CARD10/PRKCQ/CCL19/MALT1/TIRAP/CHUK/XIAP/CCL4/LAT	59
KEGG	hsa04062	Chemokine signaling pathway	101/3397	192/8135	0.001398	0.01343	0.009521	CCR2/CX3CR1/RAC2/LYN/RAP1B/STAT3/HCK/RASGRP2/GNAI3/GNB1/GNB2/MAP2K1/STAT1/PPBP/GNG5/CXCL9/JAK2/CXCL11/PRKACB/NFKBIA/CXCL10/GRK6/NFKB1/KRAS/GSK3B/GRK5/CXCL12/PIK3R3/RELA/GNG7/ARRB1/GNAQ/PAK1/PTK2B/PRKCD/IKBKG/CXCL13/NCF1/FGR/HRAS/NFKBIB/CCL5/PLCG2/RAP1A/SHC1/PIK3R6/CRK/RAF1/CCL7/RAC1/ITK/ADCY7/CXCR1/GNG2/CCR5/GNB3/ADCY1/PTK2/CCL13/ADCY3/GNAI2/CCL8/PIK3CD/CCR6/PRKACA/NRAS/CXCR6/CCR4/GRB2/GNB4/ELMO1/PXN/PLCB1/CCR3/VAV1/CXCR2/CCL20/PREX1/CCL26/MAPK1/BAD/GNG11/GRK4/GNG12/PIK3CG/PRKCZ/RHOA/CX3CL1/SHC3/CXCR3/CCL19/CHUK/CCL4/CCR7/WAS/ROCK2/SHC4/CCL24/CXCL6/FOXO3/PIK3CB	101
KEGG	hsa04150	mTOR signaling pathway	84/3397	156/8135	0.001407	0.01343	0.009521	IGF1/RPS6KA2/WNT5A/TSC1/STRADB/ATP6V1C1/RPS6KA3/MAP2K1/ULK2/CAB39L/PRR5/DVL2/TNF/SKP2/KRAS/GSK3B/PIK3R3/LRP5/WDR24/SEH1L/CLIP1/INSR/SLC7A5/FZD9/IGF1R/EIF4B/HRAS/ATP6V1A/LAMTOR1/RRAGD/NPRL3/RAF1/ATP6V1G3/EIF4E2/ATP6V1B2/MLST8/FLCN/ATP6V1D/GRB10/FNIP1/LAMTOR4/PIK3CD/NRAS/MAP2K2/GRB2/AKT1S1/TBC1D7/DDIT4/FZD5/ATP6V1G2/RRAGA/FZD1/LAMTOR5/ULK1/FZD4/DVL1/DEPTOR/WNT1/PRKAA1/MAPK1/TELO2/NPRL2/EIF4E/RPS6KB2/MAPKAP1/FZD7/WNT2B/MTOR/RHOA/WNT6/DEPDC5/FZD2/ATP6V1B1/WNT10A/CHUK/STRADA/WNT7A/WNT10B/SESN2/PRKCA/TTI1/SLC38A9/FZD10/PIK3CB	84
KEGG	hsa05165	Human papillomavirus infection	165/3397	331/8135	0.001471	0.01365	0.00968	ATP6V0D2/FN1/PTGER4/MPP5/CDKN1A/NOTCH2/RBPJ/PPP2CA/IRF1/WNT5A/TSC1/ITGA5/ATP6AP1/CCND3/ITGB7/PTGS2/ITGB5/SPP1/ATP6V1C1/MAP2K1/LFNG/STAT1/LAMB2/OASL/IFNAR1/FAS/BCAP31/DVL2/TNF/PRKACB/ATP6V0C/NFKB1/KRAS/GSK3B/PIK3R3/CCND2/THBS3/TICAM1/NOTCH3/PKM/RELA/UBE3A/CDK4/MX2/CREB5/PPP2R3A/IRF9/LAMC3/COL4A2/HLA-F/IKBKG/TCIRG1/ITGA4/ITGA7/FZD9/LAMB3/TRAF3/HLA-E/HLA-B/VEGFA/CASP3/HRAS/ATP6V1A/ITGA11/CASP8/CREB3L2/ISG15/HEY1/CREB1/TRADD/RAF1/ATP6V1G3/CCND1/HLA-G/ATP6V1B2/PPP2R5C/TCF7L1/CREB3L4/HLA-C/ATP6V1D/PTK2/ATM/CSNK1A1/HDAC2/CCNE1/PPP2R2D/ATP6V0E2/BAX/PPP2R2B/PIK3CD/CDKN1B/TYK2/MX1/PRKACA/NRAS/RBPJL/ITGA2/PPP2R3C/CREB3/MAP2K2/GRB2/FZD5/PARD6B/VWF/ITGA3/HES1/ATP6V1G2/FZD1/PXN/TUBG2/PPP2R1B/EIF2AK2/EGFR/FADD/TBPL1/ATR/COL2A1/FZD4/HEY2/DVL1/WNT1/LAMA2/PSEN1/MDM2/CCNA1/MAPK1/TCF7L2/NOTCH4/PSMC1/COL4A3/TNXB/BAD/ITGA8/RBL2/HLA-A/JAK1/LLGL1/RPS6KB2/COL6A3/RB1/CCNA2/TLR3/PPP2R5B/FZD7/WNT2B/IFNAR2/TERT/PRKCZ/RELN/TBP/MTOR/WNT6/IBSP/FZD2/ATP6V1B1/WNT10A/BAK1/CHUK/WNT7A/TADA3/WNT10B/PPP2R2C/FZD10/PIK3CB/LAMA1	165
KEGG	hsa05321	Inflammatory bowel disease	39/3397	65/8135	0.002219	0.02003	0.0142	NOD2/IL2RG/TLR2/STAT6/STAT3/STAT1/SMAD2/IL4R/TNF/NFKB1/RELA/IL21R/IFNGR2/MAF/TGFB1/IL18R1/TLR5/TLR4/HLA-DPB1/HLA-DPA1/IL1B/HLA-DMB/HLA-DOB/IL6/HLA-DRA/HLA-DMA/NFATC1/IL1A/IL12RB1/IFNGR1/IL18/TGFB3/RORA/IFNG/IL12B/TBX21/IL18RAP/IL23A/HLA-DOA	39
KEGG	hsa04668	TNF signaling pathway	62/3397	112/8135	0.002396	0.02028	0.01438	JUNB/FOS/NOD2/MAPK12/SOCS3/IRF1/PTGS2/TNFAIP3/MAP2K1/BIRC2/CEBPB/MAP3K8/IL15/FAS/TNF/NFKBIA/CXCL10/NFKB1/PIK3R3/ATF4/RELA/CREB5/IL18R1/TAB3/MAPK13/IKBKG/TRAF3/CASP3/CASP8/IL1B/CREB3L2/CCL5/CREB1/TRADD/CASP7/IL6/CREB3L4/MAPK8/TAB1/MMP9/PIK3CD/BIRC3/MMP3/CREB3/MLKL/MMP14/MAP3K5/TRAF1/DNM1L/FADD/TRAF2/CCL20/MAPK1/MAP2K4/TRAF5/MAPK11/CX3CL1/CHUK/ATF6B/CXCL6/PIK3CB/MAPK9	62
KEGG	hsa05145	Toxoplasmosis	62/3397	112/8135	0.002396	0.02028	0.01438	MYD88/ALOX5/TLR2/MAPK12/HSPA6/STAT3/GNAI3/CD40/BIRC2/LY96/STAT1/LAMB2/JAK2/TNF/NFKBIA/NFKB1/RELA/IFNGR2/IRAK4/TGFB1/LAMC3/MAPK13/TRAF6/IKBKG/TLR4/LAMB3/HLA-DPB1/HLA-DPA1/CASP3/NFKBIB/CASP8/LDLR/PIK3R6/HLA-DMB/HLA-DOB/HLA-DRA/CCR5/HLA-DMA/MAPK8/TAB1/BCL2/GNAI2/TYK2/BIRC3/BIRC7/HSPA1L/IFNGR1/LAMA2/MAPK1/SOCS1/BAD/TGFB3/IFNG/JAK1/MAPK11/PIK3CG/IL12B/CHUK/XIAP/HLA-DOA/MAPK9/LAMA1	62
KEGG	hsa05164	Influenza A	90/3397	171/8135	0.002429	0.02028	0.01438	MYD88/SOCS3/IRF7/NXF1/CCND3/NLRP3/RAB11A/TNFRSF10A/MAP2K1/STAT1/JAK2/IFNAR1/FAS/TNF/NFKBIA/CXCL10/NFKB1/PIK3R3/TICAM1/RELA/IFNGR2/ACTB/CDK4/MX2/IRAK4/DNAJB1/NXT1/IRF9/IKBKG/TLR4/DDX58/TRAF3/HLA-DPB1/OAS3/HLA-DPA1/CASP3/RSAD2/TNFSF10/NFKBIB/CASP8/IL1B/CCL5/PML/FDPS/OAS2/HLA-DMB/TRADD/RAF1/HNRNPUL1/HLA-DOB/EIF2S1/TPSAB1/MAVS/IL6/HLA-DRA/SLC25A5/PRSS3/HLA-DMA/IFIH1/BAX/PIK3CD/TYK2/MX1/IL1A/CASP1/RNASEL/MAP2K2/VDAC1/TPSB2/NXT2/TNFRSF10B/IFNGR1/EIF2AK2/IL18/FADD/MAPK1/KPNA1/IFNG/JAK1/NLRX1/TLR3/IFNAR2/IL12B/ADAR/BAK1/CHUK/PRKCA/HLA-DOA/PRSS2/PIK3CB	90
KEGG	hsa05170	Human immunodeficiency virus 1 infection	109/3397	212/8135	0.00255	0.02077	0.01473	MYD88/FOS/TLR2/RAC2/MAPK12/GNAI3/CUL1/GNB1/GNB2/AP1B1/TAP2/MAP2K1/TAP1/GNG5/FAS/TNF/LIMK2/NFKBIA/PDIA3/NFKB1/KRAS/PIK3R3/RELA/GNG7/IRAK4/PPP3CB/NFATC3/ITPR1/GNAQ/PAK1/PTK2B/CFL2/MAPK13/HLA-F/TRAF6/IKBKG/DDB1/TLR4/HLA-E/HLA-B/CASP3/HRAS/CASP8/PAK2/CD3D/SAMHD1/PLCG2/CRK/TRADD/RAF1/HLA-G/RAC1/APOBEC3G/AP1M2/AP1G2/GNG2/APOBEC3C/CCR5/TAPBP/GNB3/HLA-C/RNF7/PTK2/ATM/MAPK8/TAB1/BCL2/GNAI2/NFATC1/BAX/CD247/NFATC2/PIK3CD/CFL1/NRAS/CD3G/MAP2K2/GNB4/CALR/PXN/AP1S3/FADD/ATR/TRAF2/CALML3/AP1G1/APOBEC3B/MAPK1/BAD/WEE1/GNG11/TRAF5/HLA-A/MAPK11/RPS6KB2/AP1M1/CUL4B/CD4/GNG12/MTOR/RBX1/CCNB3/BAK1/CHUK/CD3E/PRKCA/GNA11/PIK3CB/MAPK9	109
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	12/3397	15/8135	0.002967	0.02319	0.01645	HEXB/SLC33A1/HEXA/ST6GALNAC4/ST3GAL2/B4GALNT1/ST6GALNAC5/ST3GAL1/ST6GALNAC3/ST6GALNAC6/ST8SIA1/ST3GAL5	12
KEGG	hsa05160	Hepatitis C	83/3397	157/8135	0.002986	0.02319	0.01645	CDKN1A/SOCS3/IRF7/PPP2CA/STAT3/MAP2K1/STAT1/YWHAH/MYC/SCARB1/IFNAR1/FAS/TNF/NFKBIA/CXCL10/NFKB1/KRAS/GSK3B/PIK3R3/TICAM1/RELA/CDK4/MX2/IRF9/CLDN2/TRAF6/IKBKG/DDX58/TRAF3/OAS3/CASP3/HRAS/RSAD2/CASP8/CLDN7/LDLR/ARAF/OAS2/TRADD/RAF1/CCND1/EIF2S1/MAVS/RXRA/PSME3/PPP2R2D/BAX/PPP2R2B/PIK3CD/TYK2/NR1H3/MX1/NRAS/RNASEL/MAP2K2/GRB2/IFIT1/YWHAQ/CLDN23/PPP2R1B/EIF2AK2/EGFR/PPARA/FADD/TRAF2/MAPK1/YWHAE/EIF2AK1/BAD/IFNG/JAK1/CLDN18/RB1/TLR3/YWHAG/IFNAR2/EIF2AK4/CLDN15/BAK1/CHUK/PPP2R2C/CLDN6/PIK3CB	83
KEGG	hsa00480	Glutathione metabolism	35/3397	58/8135	0.00321	0.02411	0.0171	SMS/GCLM/LAP3/MGST2/GSTP1/GSR/GPX7/GGCT/GCLC/GSTO1/ODC1/GPX3/GSTA1/IDH1/GPX4/GSTM3/G6PD/IDH2/TXNDC12/MGST1/GSTM5/PRDX6/GSS/HPGDS/RRM2/GSTM4/RRM2B/GGT7/MGST3/GGT5/SRM/PGD/LANCL1/CHAC2/GPX1	35
KEGG	hsa04917	Prolactin signaling pathway	41/3397	70/8135	0.003248	0.02411	0.0171	FOS/MAPK12/SOCS3/IRF1/STAT3/MAP2K1/STAT1/JAK2/CISH/NFKB1/KRAS/GSK3B/PIK3R3/CCND2/RELA/SOCS5/MAPK13/SOCS6/HRAS/STAT5A/SHC1/TNFRSF11A/RAF1/CCND1/SOCS7/MAPK8/PIK3CD/NRAS/MAP2K2/GRB2/GALT/MAPK1/SOCS1/MAPK11/ELF5/SHC3/SHC4/SOCS2/FOXO3/PIK3CB/MAPK9	41
KEGG	hsa05017	Spinocerebellar ataxia	76/3397	143/8135	0.003658	0.02656	0.01884	RBPJ/ULK2/ATG14/PSMA5/PSMD11/PIK3R3/CIC/ITPR1/GNAQ/ATG101/PSMA1/PSMA4/MCU/RYR1/OMA1/PSMB1/PSMC4/ADRM1/PSMD13/ATG13/WIPI1/PSMB3/AFG3L2/SLC25A5/ATXN2/PUM2/PSMB5/PSMD6/PSMC3/ATXN2L/KAT5/MAPK8/PSMC6/PIK3CD/RBPJL/ATG2B/DAB1/VDAC2/MAP3K5/GRIN2C/VDAC1/ATXN3/BEAN1/PLCB1/ULK1/TBPL1/TRAF2/ATP2A2/ATXN1L/PSMC1/PSMD8/RORA/PSMA2/ATXN1/SPTBN2/ATXN10/PSMC5/PSMC2/PSMB2/PSMD4/RELN/TBP/VDAC3/MTOR/ERN1/NRBF2/PSMD1/ATXN3L/PSMB4/PRKCA/GRIA2/PSMD9/PSMD3/PIK3CB/MAPK9/ATXN8OS	76
KEGG	hsa04144	Endocytosis	126/3397	251/8135	0.003745	0.02661	0.01887	IL2RG/STAM/ARF6/SNX1/WWP1/DNM3/HSPA6/ARAP1/CYTH4/RNF41/RAB11A/ARAP3/SMAD2/FOLR2/CYTH1/GRK6/VPS37B/RAB31/ASAP2/ACTR2/GRK5/PLD1/CHMP4B/ARRB1/CBLB/ARF4/CAPZA2/HLA-F/TRAF6/ARFGEF1/IL2RB/ARF5/IGF1R/HLA-E/HLA-B/EHD4/HRAS/IGF2R/ARFGAP3/CLTB/ARPC1A/IQSEC1/RAB11FIP4/VPS37C/LDLR/VTA1/CAPZA1/PML/EHD1/RAB8A/HLA-G/AGAP4/ARPC1B/CXCR1/CCR5/CLTCL1/HLA-C/ARF1/SNX6/DNAJC6/SH3GL1/ARPC5L/DNM1/AP2A2/WIPF2/DNM2/NEDD4/RAB5C/CHMP2A/TSG101/RAB5A/IST1/ACAP1/HGS/AP2S1/ACTR3B/CHMP1A/VPS4B/PARD6B/ACTR3/AP2A1/HSPA1L/VPS25/RABEP1/EGFR/CXCR2/CAV3/IQSEC2/TFRC/PLD2/RAB22A/MDM2/VPS29/SNX5/RAB35/SH3GLB1/STAMBP/ARPC4/HLA-A/IQSEC3/KIF5B/GRK4/EHD3/SNX4/ACAP3/AGAP3/PSD4/WIPF1/ARPC2/AGAP1/VPS26B/AP2M1/PRKCZ/PIP5K1B/RHOA/ACAP2/ASAP1/CHMP1B/ASAP3/ARF3/SMAP2/ARFGAP1/BIN1/PSD3/AMPH/SNX32	126
KEGG	hsa05162	Measles	74/3397	139/8135	0.003874	0.02696	0.01911	MYD88/FOS/IL2RG/TLR2/RAB9A/IRF7/HSPA6/STAT3/CCND3/TNFAIP3/STAT1/IFNAR1/FAS/NFKBIA/NFKB1/GSK3B/PIK3R3/SLAMF1/CCND2/RELA/CSNK2A2/CDK4/MX2/IRAK4/CBLB/IRF9/TRAF6/IKBKG/TLR4/DDX58/TRAF3/IL2RB/OAS3/CD209/CASP3/NFKBIB/CASP8/STAT5A/IL1B/CD3D/OAS2/CSNK2B/TRADD/CCND1/EIF2S1/MAVS/IL6/IFIH1/MAPK8/CCNE1/BCL2/BAX/PIK3CD/CDKN1B/TYK2/MX1/IL1A/CD3G/HSPA1L/EIF2AK2/FADD/EIF2AK1/MSN/BAD/JAK1/IFNAR2/IL12B/EIF2AK4/ADAR/BAK1/CHUK/CD3E/PIK3CB/MAPK9	74
KEGG	hsa00071	Fatty acid degradation	27/3397	43/8135	0.004278	0.02916	0.02068	ALDH3A2/HADHB/ALDH9A1/HADH/ACAA1/ALDH7A1/ADH5/ACSL5/CPT2/ACADM/ACADS/ACSL4/ALDH2/ACOX1/ECI2/ACADSB/ACSL6/ECI1/CPT1A/EHHADH/ACADVL/HADHA/ADH1B/ACAA2/ACOX3/ADH7/CYP2U1	27
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	45/3397	79/8135	0.004411	0.02947	0.0209	IGF1/STAT3/MAP2K1/JAK2/KRAS/GSK3B/GAB1/PIK3R3/AXL/HGF/NRG1/PDGFC/IGF1R/VEGFA/HRAS/PLCG2/ARAF/SHC1/RAF1/EIF4E2/IL6/PDGFB/BCL2L11/BCL2/BAX/PIK3CD/NRAS/MAP2K2/GRB2/PDGFA/EGFR/MAPK1/BAD/EIF4E/JAK1/RPS6KB2/MTOR/SHC3/MET/SHC4/PRKCA/ERBB3/PDGFD/FOXO3/PIK3CB	45
KEGG	hsa05142	Chagas disease	56/3397	102/8135	0.004815	0.03153	0.02236	MYD88/FOS/TLR2/MAPK12/PPP2CA/GNAI3/GNA15/SMAD2/FAS/TNF/NFKBIA/NFKB1/PIK3R3/TICAM1/RELA/IFNGR2/IRAK4/TGFB1/GNAQ/MAPK13/TRAF6/IKBKG/TLR4/CASP8/IL1B/CD3D/CCL5/IL6/ADCY1/MAPK8/GNAI2/PPP2R2D/CD247/PPP2R2B/SERPINE1/PIK3CD/CD3G/CALR/PLCB1/PPP2R1B/IFNGR1/FADD/MAPK1/MAP2K4/C1QC/TGFB3/IFNG/MAPK11/IL12B/CHUK/CD3E/TLR6/GNA11/PPP2R2C/PIK3CB/MAPK9	56
KEGG	hsa01522	Endocrine resistance	54/3397	98/8135	0.005041	0.03238	0.02296	IGF1/FOS/DLL1/CDKN1A/MAPK12/NOTCH2/MAP2K1/PRKACB/KRAS/PIK3R3/NOTCH3/CDK4/NCOA3/MAPK13/IGF1R/HRAS/ARAF/SHC1/RAF1/CCND1/ADCY7/ADCY1/PTK2/NCOR1/CYP2D6/MAPK8/MMP9/BCL2/ADCY3/BAX/PIK3CD/CDKN1B/CDKN2C/PRKACA/NRAS/MAP2K2/GRB2/ABCB11/EGFR/MDM2/MAPK1/NOTCH4/BAD/MAPK11/RPS6KB2/HBEGF/RB1/CARM1/MMP2/MTOR/SHC3/SHC4/PIK3CB/MAPK9	54
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	226/3397	476/8135	0.005385	0.03394	0.02407	TUBA1A/MAPK12/PINK1/WNT5A/SOD1/C9orf72/CAPN2/UQCRC2/PTGS2/KLC1/TUBB6/MAP2K1/ULK2/ALS2/ATG14/UCHL1/SQSTM1/FAS/UQCR11/PSMA5/DVL2/TNF/PSMD11/NDUFA8/NFKB1/IFT57/KRAS/GSK3B/ATF4/LRP5/GPX7/RELA/TUBB2A/CSNK2A2/NDUFC1/PPP3CB/ITPR1/MAP1LC3A/GNAQ/NDUFB11/ATG101/PSMA1/PSMA4/MAPK13/MCU/NDUFS3/HTRA2/RYR1/FZD9/HSPA5/FIG4/NDUFA3/CDK5/CAT/CASP3/UBE2L6/HRAS/TUBB3/CASP8/PSMB1/IL1B/PSMC4/NDUFA11/AGER/ADRM1/FRAT2/GPX3/UBE2J1/FRAT1/ARAF/PSMD13/CSNK2B/ATG13/WIPI1/VAPB/RAB8A/RAF1/PSMB3/CASP7/UQCR10/COX7C/RAC1/EIF2S1/UBE2G2/IL6/DNAL1/SLC25A5/LRRK2/MAP1LC3C/ATXN2/PSEN2/PSMB5/COX7A2L/PSMD6/CSNK1A1/NDUFA4/CSNK1E/PSMC3/ATXN2L/ZFYVE1/COX4I2/NDUFA1/MAPK8/BCL2/TUBA1C/BAX/PSMC6/HSD17B10/RAB39B/DNAI2/FUS/DNAH17/TOMM40L/NRAS/DCTN2/RAB5A/IL1A/TUBA4A/DERL1/ATG2B/UBC/MAP2K2/TOMM40/NDUFA10/VDAC2/NDUFB1/CYBB/NDUFB5/FZD5/UQCRQ/MAP3K5/CAMK2A/GRIN2C/VDAC1/FZD1/ATXN3/NDUFS1/DKK2/CAMK2D/PLCB1/ULK1/DNAL4/FADD/TRAF2/ATP2A2/NDUFB8/FZD4/CALML3/ATXN1L/TUBB4A/DVL1/WNT1/PSEN1/MAPK1/TUBAL3/SMCR8/PSMC1/DNAI1/NDUFB6/TUBB1/BAD/TUBA1B/PSMD8/PSMA2/MAPK11/ATXN1/KIF5B/KLC4/SPTBN2/NDUFB3/FZD7/SDHA/WNT2B/PSMC5/OPTN/KLC2/UBE2G1/PSMC2/GPX1/PSMB2/PSMD4/DNAH10/SNCAIP/VCP/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/MTOR/APP/WNT6/ERN1/SNCA/UQCRB/FZD2/SIGMAR1/WNT10A/NRBF2/NDUFB2/BAK1/DCTN6/COX6C/PSMD1/WNT7A/UBA1/ATXN3L/WNT10B/PSMB4/DCTN5/KLC3/DAXX/CACNA1F/DNAH8/NDUFS2/TARDBP/PRKCA/GRIA2/DNAH2/PSMD9/PSMD3/NDUFA7/FZD10/CAMK2B/MAPK9/COX7B	226
KEGG	hsa05418	Fluid shear stress and atherosclerosis	73/3397	139/8135	0.006359	0.03933	0.02789	NQO1/FOS/KLF2/RAC2/DUSP1/IL1R2/MAPK12/ACVR2B/MEF2A/KEAP1/SQSTM1/MGST2/GSTP1/TNF/HMOX1/NFKB1/PIK3R3/RELA/ACTB/MAPK7/MAPK13/NCF2/IKBKG/NCF1/VEGFA/GSTO1/IL1B/ARHGEF2/GSTA1/THBD/IL1R1/RAC1/PDGFB/CDH5/GSTM3/SUMO1/PTK2/MGST1/BMPR1A/MAPK8/MMP9/BCL2/BMP4/GSTM5/PIK3CD/IL1A/PDGFA/CYBA/GSTM4/MAP3K5/NFE2L2/TXN/CAV3/HSP90B1/CALML3/PRKAA1/MGST3/MAP2K4/IFNG/MAPK11/SUMO4/HSP90AB1/MAP2K5/MMP2/PRKCZ/RHOA/TRPV4/CHUK/BMPR1B/MEF2C/PIK3CB/MAPK9/BMPR2	73
KEGG	hsa05417	Lipid and atherosclerosis	108/3397	215/8135	0.00676	0.04065	0.02883	MYD88/FOS/TLR2/MAPK12/LYN/IRF7/OLR1/RAP1B/HSPA6/STAT3/NLRP3/TNFRSF10A/CD40/LY96/CASP6/JAK2/FAS/TNF/NFKBIA/NFKB1/KRAS/GSK3B/PIK3R3/TICAM1/POU2F1/ATF4/RELA/MIB1/IRAK4/PPP3CB/NFATC3/ITPR1/POU2F2/CD36/NCF4/MAPK13/TRAF6/NCF2/IKBKG/NCF1/CYP2J2/TLR4/TRAF3/HSPA5/CASP3/HRAS/TNFSF10/CASP8/ABCA1/IL1B/AGER/CCL5/LDLR/RAP1A/CASP7/RAC1/EIF2S1/IL6/PTK2/RXRA/MAPK8/TAB1/MMP9/BCL2/NFATC1/BAX/NFATC2/PIK3CD/ABCG1/MMP3/NRAS/CASP1/MMP1/CYBA/CYBB/MAP3K5/CAMK2A/HSPA1L/NFE2L2/TNFRSF10B/CAMK2D/PLCB1/VAV1/IL18/TRAF2/HSP90B1/CALML3/HSPA4/MAPK1/APOA1/MAP2K4/BAD/MAPK11/HSP90AB1/LBP/IL12B/RHOA/ERN1/TIRAP/CHUK/ROCK2/CYP2A6/CYP2C8/PRKCA/TLR6/PIK3CB/CAMK2B/MAPK9	108
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	53/3397	97/8135	0.006816	0.04065	0.02883	VASP/RAC2/ARF6/LYN/FCGR1A/MARCKSL1/HCK/FCGR3B/MAP2K1/PTPRC/LIMK2/ASAP2/ACTR2/PIK3R3/PLD1/PAK1/MARCKS/CFL2/PRKCD/NCF1/ARPC1A/PLCG2/CRK/RAF1/RAC1/ARPC1B/SPHK1/ARPC5L/DNM2/PIK3CD/CFL1/ACTR3B/ACTR3/VAV1/SCIN/PLD2/MAPK1/PLA2G6/ARPC4/MYO10/RPS6KB2/FCGR2A/ARPC2/PIP5K1B/ASAP1/WAS/INPPL1/ASAP3/PRKCA/BIN1/AMPH/LAT/PIK3CB	53
KEGG	hsa04068	FoxO signaling pathway	69/3397	131/8135	0.007178	0.04206	0.02983	IGF1/KLF2/S1PR4/CDKN2D/CDKN1A/MAPK12/STAT3/BCL6/S1PR1/MAP2K1/SKP2/KRAS/PIK3R3/CCND2/IL7R/TGFB1/GADD45B/PCK2/INSR/MAPK13/IGF1R/CDKN2B/PLK2/CAT/HRAS/TNFSF10/HOMER3/NLK/ARAF/RAF1/SIRT1/CCND1/HOMER1/SETD7/IL6/IRS2/ATM/CSNK1E/PRKAG2/BCL2L11/PLK3/MAPK8/PIK3CD/CDKN1B/NRAS/MAP2K2/GRB2/FOXO4/EGFR/USP7/PRKAA1/MDM2/MAPK1/TGFB3/RBL2/MAPK11/PRKAG1/GABARAPL1/FBXO25/CCNG2/CCNB3/CHUK/PRMT1/G6PC/FOXO3/PIK3CB/ATG12/MAPK9/PRKAB1	69
KEGG	hsa04620	Toll-like receptor signaling pathway	56/3397	104/8135	0.008212	0.04649	0.03297	MYD88/FOS/TLR1/TLR2/MAPK12/IRF7/SPP1/CD40/MAP2K1/LY96/STAT1/CXCL9/MAP3K8/CXCL11/CTSK/IFNAR1/TNF/NFKBIA/CXCL10/NFKB1/PIK3R3/TICAM1/RELA/IRAK4/TLR5/MAPK13/TRAF6/IKBKG/TLR4/TRAF3/CASP8/IL1B/CCL5/RAC1/IL6/MAPK8/TAB1/PIK3CD/TOLLIP/MAP2K2/FADD/TLR8/MAPK1/MAP2K4/MAPK11/TLR3/LBP/IFNAR2/IL12B/CD80/TIRAP/CHUK/CCL4/TLR6/PIK3CB/MAPK9	56
KEGG	hsa04625	C-type lectin receptor signaling pathway	56/3397	104/8135	0.008212	0.04649	0.03297	MAPK12/CLEC7A/BCL10/IRF1/CLEC4D/EGR3/PTGS2/NLRP3/CLEC4E/STAT1/RRAS/TNF/NFKBIA/NFKB1/KRAS/PIK3R3/RELA/PPP3CB/NFATC3/ITPR1/CBLB/PAK1/IRF9/PRKCD/MAPK13/NFKB2/IKBKG/CD209/HRAS/RELB/CASP8/IL1B/PLCG2/RAF1/EGR2/IL6/CYLD/PLK3/MAPK8/MAPKAPK2/NFATC1/NFATC2/PIK3CD/NRAS/CASP1/CALML3/MDM2/MAPK1/MAPK11/IL12B/RHOA/MALT1/CHUK/IL23A/PIK3CB/MAPK9	56
KEGG	hsa05146	Amoebiasis	55/3397	102/8135	0.008439	0.04671	0.03312	ITGAM/FN1/TLR2/SERPINB9/IL1R2/ARG2/GNA15/CD1C/ACTN4/LAMB2/VCL/CD1E/TNF/PRKACB/NFKB1/PIK3R3/RELA/TGFB1/GNAQ/HSPB1/PRDX1/LAMC3/COL4A2/ACTN1/TLR4/LAMB3/CASP3/IL1B/CD1B/MUC2/IL1R1/IL6/ADCY1/PTK2/RAB5C/PIK3CD/PRKACA/RAB5A/CD1D/CD1A/RAB7B/PLCB1/LAMA2/COL4A3/TGFB3/IFNG/SERPINB4/CTSG/IL12B/SERPINB6/SERPINB10/PRKCA/GNA11/PIK3CB/LAMA1	55
KEGG	hsa04722	Neurotrophin signaling pathway	63/3397	119/8135	0.008592	0.04671	0.03312	SH2B2/RPS6KA2/MAPK12/RAP1B/RPS6KA3/MAP2K1/MAGED1/IRAK3/NFKBIA/ARHGDIA/NFKB1/KRAS/GSK3B/GAB1/PIK3R3/ATF4/RELA/IRAK4/MAPK7/PRKCD/MAPK13/TRAF6/ARHGDIB/HRAS/ABL1/NFKBIB/PRDM4/PLCG2/RAP1A/SHC1/CRK/RAF1/RAC1/PSEN2/MAPK8/BCL2/MAPKAPK2/BAX/PIK3CD/NRAS/MAP2K2/GRB2/NFKBIE/MAP3K5/CAMK2A/CAMK2D/CALML3/PSEN1/MAPK1/YWHAE/BAD/MATK/MAPK11/MAP3K1/MAP2K5/RHOA/SHC3/SHC4/FOXO3/NTRK2/PIK3CB/CAMK2B/MAPK9	63
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	54/3397	100/8135	0.00867	0.04671	0.03312	FN1/MAPK12/STAT3/PIM1/DIAPH1/VEGFB/STAT1/SMAD2/JAK2/EGR1/TNF/NFKB1/KRAS/PIK3R3/RELA/CDK4/TGFB1/COL4A2/PRKCD/MAPK13/VEGFA/CASP3/HRAS/STAT5A/IL1B/AGER/PLCG2/THBD/CCND1/RAC1/IL6/MAPK8/BCL2/NFATC1/BAX/SERPINE1/PIK3CD/CDKN1B/NRAS/IL1A/CYBB/PLCD1/PLCB1/PLCD4/MAPK1/COL4A3/TGFB3/MAPK11/F3/MMP2/PRKCZ/PRKCA/PIK3CB/MAPK9	54
KEGG	hsa05211	Renal cell carcinoma	39/3397	69/8135	0.009199	0.04752	0.03369	EPAS1/CDKN1A/RAP1B/MAP2K1/KRAS/GAB1/PIK3R3/TGFB1/HGF/HIF1A/PAK1/VEGFA/EGLN1/HRAS/PAK2/RAP1A/ARAF/CRK/RAF1/RAC1/TFE3/PDGFB/EGLN3/FLCN/ETS1/ARNT2/FH/PIK3CD/NRAS/MAP2K2/GRB2/ARNT/MAPK1/CUL2/BAD/TGFB3/RBX1/MET/PIK3CB	39
KEGG	hsa04621	NOD-like receptor signaling pathway	93/3397	184/8135	0.009251	0.04752	0.03369	MYD88/NOD2/NAMPT/GBP2/MAPK12/IRF7/TXNIP/GBP1/NLRP3/TNFAIP3/BIRC2/STAT1/PSTPIP1/TRIP6/NLRP12/IFNAR1/P2RX7/TNF/NFKBIA/GBP5/NFKB1/AIM2/TICAM1/RELA/IRAK4/ITPR1/MAP1LC3A/IRF9/PANX1/GBP4/PRKCD/TAB3/MAPK13/TRAF6/IKBKG/MCU/TLR4/TRAF3/OAS3/NFKBIB/CASP8/IL1B/CCL5/CTSB/OAS2/CASP5/RBCK1/TRPM2/MAVS/IL6/MAP1LC3C/MAPK8/TAB1/MEFV/BCL2/TYK2/BIRC3/CASP1/RNASEL/VDAC2/CYBA/CYBB/DNM1L/VDAC1/PLCB1/TXN/IL18/PKN2/FADD/TRAF2/CASP4/ANTXR2/MAPK1/YWHAE/CARD6/NLRP1/TRAF5/JAK1/MAPK11/GPRC6A/GABARAPL1/NLRX1/HSP90AB1/IFNAR2/VDAC3/RHOA/BRCC3/CHUK/XIAP/NEK7/TRPV2/ATG12/MAPK9	93
KEGG	hsa00010	Glycolysis / Gluconeogenesis	38/3397	67/8135	0.009351	0.04752	0.03369	HK3/ALDH3A2/LDHA/FBP1/PGK1/ALDH9A1/PFKM/PFKP/GAPDH/GALM/ALDH7A1/ADH5/PGAM1/PKM/TPI1/PCK2/AKR1A1/ALDOC/ENO1/ALDOA/ALDH2/GPI/LDHB/PGM2/LDHC/LDHAL6B/PDHB/PGK2/DLAT/ADH1B/PDHA2/ENO2/MINPP1/ADPGK/PFKL/ALDH3A1/ADH7/G6PC	38
KEGG	hsa04657	IL-17 signaling pathway	51/3397	94/8135	0.00939	0.04752	0.03369	S100A9/S100A8/FOS/MAPK12/FOSB/IL17RA/JUND/PTGS2/TNFAIP3/CEBPB/TNF/NFKBIA/CXCL10/NFKB1/GSK3B/RELA/MAPK7/TAB3/MAPK13/TRAF6/IKBKG/TRAF3/CASP3/CASP8/IL1B/TRADD/CCL7/IL6/ANAPC5/MAPK8/MMP9/MMP3/MMP1/FADD/TRAF2/CCL20/HSP90B1/MAPK1/IL25/IL17B/TRAF5/FOSL1/IFNG/MAPK11/HSP90AB1/CHUK/TRAF4/IL17RB/IL17RC/CXCL6/MAPK9	51
KEGG	hsa04218	Cellular senescence	80/3397	156/8135	0.009649	0.0481	0.03411	CDKN1A/MAPK12/TSC1/CCND3/CAPN2/MAP2K1/SMAD2/SQSTM1/MYC/RRAS/NFKB1/KRAS/PIK3R3/CCND2/RELA/CDK4/RAD1/TGFB1/PPP3CB/NFATC3/GADD45B/ITPR1/RASSF5/MAPK13/HLA-F/MCU/HLA-E/HLA-B/CDKN2B/HRAS/RBBP4/RAF1/SIRT1/CCND1/HLA-G/IL6/SLC25A5/HLA-C/ETS1/ATM/CCNE1/MAPKAPK2/NFATC1/SERPINE1/NFATC2/PIK3CD/LIN9/NRAS/IL1A/CDC25A/MAP2K2/VDAC2/HIPK1/LIN54/VDAC1/E2F4/PPP1CC/PPP1CA/KIR2DL4/ATR/CALML3/MDM2/CCNA1/MAPK1/ZFP36L2/TGFB3/RBL2/HLA-A/RAD9A/MAPK11/HIPK3/PPP1CB/RB1/CCNA2/VDAC3/MTOR/TRPV4/CCNB3/FOXO3/PIK3CB	80
KEGG	hsa04216	Ferroptosis	25/3397	41/8135	0.01002	0.04923	0.03491	SLC40A1/ATG7/GCLM/NCOA4/ACSL5/SLC7A11/HMOX1/SAT1/PCBP1/MAP1LC3A/FTL/STEAP3/ACSL4/GCLC/SLC39A8/GPX4/MAP1LC3C/ACSL6/GSS/PCBP2/VDAC2/CYBB/TFRC/VDAC3/LPCAT3	25
KEGG	hsa00270	Cysteine and methionine metabolism	30/3397	51/8135	0.01019	0.04932	0.03497	LACC1/SMS/LDHA/GCLM/MDH1/IL4I1/ADI1/AHCY/MTR/APIP/GCLC/ENOPH1/LDHB/MTAP/LDHC/TST/LDHAL6B/MPST/CTH/BHMT/GSS/GOT2/AHCYL2/AGXT2/AHCYL1/DNMT3A/SRM/BCAT2/PHGDH/MAT1A	30
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	39/3397	70/8135	0.01253	0.05978	0.04239	ATP6V0D2/MAPK12/LYN/CSK/ATP6AP1/ATP6V1C1/F11R/NFKBIA/ATP6V0C/NFKB1/RELA/PAK1/MAPK13/IKBKG/TCIRG1/CASP3/ATP6V1A/CCL5/PLCG2/ATP6V1G3/RAC1/ATP6V1B2/CXCR1/ATP6V1D/MAPK8/ATP6V0E2/ATP6V1G2/EGFR/CXCR2/ADAM17/JAM3/MAP2K4/MAPK11/HBEGF/ATP6V1B1/MET/PTPRZ1/CHUK/MAPK9	39
KEGG	hsa04931	Insulin resistance	57/3397	108/8135	0.01302	0.06126	0.04344	RPS6KA2/SLC27A1/SLC27A3/SOCS3/STAT3/RPS6KA3/TNF/NFKBIA/NFKB1/GSK3B/PIK3R3/RELA/CREB5/CD36/PCK2/PPP1R3E/NR1H2/PRKCD/INSR/GYS1/PPP1R3D/CREB3L2/SLC27A2/ACACB/CRTC2/CREB1/IL6/IRS2/PPARGC1A/CREB3L4/PRKAG2/MAPK8/PIK3CD/PPP1R3B/NR1H3/CREB3/CPT1A/MLX/PPP1CC/PPP1CA/PPARA/GFPT1/PRKAA1/PYGM/PRKAG1/OGT/RPS6KB2/PPP1CB/PYGL/PRKCZ/MTOR/PRKCQ/GFPT2/G6PC/PIK3CB/MAPK9/PRKAB1	57
KEGG	hsa04211	Longevity regulating pathway	48/3397	89/8135	0.01324	0.06143	0.04356	IGF1/TSC1/ADIPOR1/PRKACB/NFKB1/KRAS/PIK3R3/ATF4/RELA/CREB5/ATG101/INSR/IGF1R/CAT/HRAS/CREB3L2/ATG13/CREB1/SIRT1/EIF4E2/ADCY7/IRS2/PPARGC1A/CREB3L4/ADCY1/PRKAG2/ADCY3/BAX/PIK3CD/PRKACA/NRAS/CREB3/AKT1S1/ULK1/SESN1/ADIPOR2/KL/PRKAA1/EIF4E/PRKAG1/RPS6KB2/MTOR/APPL1/SESN2/ATF6B/FOXO3/PIK3CB/PRKAB1	48
KEGG	hsa04919	Thyroid hormone signaling pathway	63/3397	121/8135	0.01354	0.06196	0.04394	NOTCH2/ATP1A1/PFKM/THRA/PFKP/MAP2K1/STAT1/MYC/PRKACB/SLC9A1/KRAS/GSK3B/PIK3R3/KAT2B/NOTCH3/ACTB/SIN3A/HIF1A/NCOA3/SLC16A10/HRAS/PLCG2/MED17/MED27/RAF1/CCND1/ATP1B2/MED16/ATP1B3/MED13/HDAC2/NCOR1/RXRA/BMP4/PIK3CD/ATP1B1/PRKACA/NRAS/SLC16A2/RCAN1/MAP2K2/MED4/MED30/PFKFB2/PLCD1/PLCB1/ATP2A2/PLCD4/KAT2A/MDM2/MAPK1/NOTCH4/BAD/ATP1B4/FXYD2/MED24/MTOR/SLCO1C1/DIO2/ATP1A2/PFKL/PRKCA/PIK3CB	63
KEGG	hsa05416	Viral myocarditis	34/3397	60/8135	0.01379	0.06222	0.04412	FYN/RAC2/CD55/CD40/ACTB/ITGAL/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/CASP3/ABL1/CASP8/HLA-DMB/DMD/CCND1/HLA-DOB/HLA-G/RAC1/HLA-DRA/EIF4G2/HLA-DMA/HLA-C/EIF4G3/ABL2/PRF1/LAMA2/EIF4G1/HLA-A/CD80/DAG1/HLA-DOA/LAMA1	34
KEGG	hsa05163	Human cytomegalovirus infection	110/3397	225/8135	0.01695	0.07548	0.05352	PTGER4/RAC2/CDKN1A/MAPK12/TSC1/PTGER2/STAT3/GNAI3/PTGS2/GNB1/GNB2/TAP2/MAP2K1/TAP1/MYC/GNG5/FAS/TNF/PRKACB/NFKBIA/AKAP13/PDIA3/NFKB1/KRAS/GSK3B/CXCL12/PIK3R3/ATF4/RELA/GNG7/CDK4/PPP3CB/CREB5/NFATC3/ITPR1/GNAQ/PTK2B/MAPK13/HLA-F/IKBKG/HLA-E/HLA-B/VEGFA/CASP3/HRAS/CASP8/IL1B/CREB3L2/CCL5/CREB1/CRK/TRADD/RAF1/CCND1/IL1R1/HLA-G/RAC1/ADCY7/IL6/GNG2/CCR5/TAPBP/CREB3L4/GNB3/ADCY1/HLA-C/PTK2/ADCY3/GNAI2/NFATC1/BAX/NFATC2/PIK3CD/PRKACA/NRAS/CREB3/MAP2K2/GRB2/GNB4/CALR/PXN/PLCB1/CCR3/EGFR/CXCR2/FADD/TRAF2/CALML3/MDM2/MAPK1/GNA13/GNG11/TRAF5/HLA-A/JAK1/MAPK11/RPS6KB2/GNG12/RB1/MTOR/RHOA/CX3CL1/BAK1/CHUK/CCL4/ROCK2/PRKCA/GNA11/ATF6B/PIK3CB	110
KEGG	hsa04152	AMPK signaling pathway	62/3397	120/8135	0.01734	0.07622	0.05405	IGF1/FBP1/PPP2CA/TSC1/PFKFB3/PFKM/PFKP/STRADB/ADIPOR1/CAB39L/HMGCR/PIK3R3/CREB5/PPP2R3A/SCD/CD36/PCK2/LEP/INSR/GYS1/TBC1D1/IGF1R/CREB3L2/ACACB/CRTC2/CREB1/RAB8A/SIRT1/CCND1/IRS2/PFKFB4/PPARGC1A/PPP2R5C/MLYCD/CREB3L4/PRKAG2/PFKFB1/PPP2R2D/PPP2R2B/PIK3CD/PPP2R3C/CREB3/CPT1A/AKT1S1/PFKFB2/PPP2R1B/ULK1/ADIPOR2/PRKAA1/CCNA1/PRKAG1/RPS6KB2/CCNA2/PPP2R5B/MTOR/STRADA/PFKL/G6PC/PPP2R2C/FOXO3/PIK3CB/PRKAB1	62
KEGG	hsa04330	Notch signaling pathway	33/3397	59/8135	0.01926	0.08354	0.05924	DLL1/NOTCH2/RBPJ/APH1B/LFNG/CTBP2/DVL2/PSENEN/KAT2B/NOTCH3/TLE1/DTX4/TLE4/DTX1/NUMB/HEY1/PSEN2/DTX3L/HDAC2/TLE6/RBPJL/HES1/ADAM17/HEY2/ATXN1L/PTCRA/DVL1/KAT2A/PSEN1/NOTCH4/NUMBL/ATXN1/APH1A	33
KEGG	hsa05215	Prostate cancer	51/3397	97/8135	0.0198	0.08479	0.06012	IGF1/IL1R2/CDKN1A/MAP2K1/GSTP1/NFKBIA/NFKB1/KRAS/GSK3B/PIK3R3/ATF4/RELA/CREB5/IKBKG/PDGFC/IGF1R/HRAS/CREB3L2/ARAF/CREB1/RAF1/CCND1/ETV5/PDGFB/TCF7L1/CREB3L4/MMP9/CCNE1/BCL2/PIK3CD/CDKN1B/MMP3/NRAS/SPINT1/CREB3/MAP2K2/GRB2/PDGFA/EGFR/HSP90B1/MDM2/MAPK1/TCF7L2/BAD/HSP90AB1/RB1/MTOR/KLK3/CHUK/PDGFD/PIK3CB	51
KEGG	hsa04612	Antigen processing and presentation	42/3397	78/8135	0.02033	0.08594	0.06094	HSPA6/NFYC/TAP2/CTSS/TAP1/LGMN/TNF/CD74/PDIA3/PSME1/HLA-F/HLA-DPB1/HLA-DPA1/HSPA5/HLA-E/HLA-B/CTSB/HLA-DMB/RFX5/CREB1/HLA-DOB/HLA-G/HLA-DRA/TAPBP/HLA-DMA/HLA-C/PSME3/CANX/CALR/HSPA1L/KIR2DL2/KIR2DL4/HSPA4/HLA-A/IFNG/KIR2DL1/KIR2DS1/CD4/HSP90AB1/CD8A/RFXANK/HLA-DOA	42
KEGG	hsa00620	Pyruvate metabolism	27/3397	47/8135	0.02143	0.08876	0.06294	ALDH3A2/LDHA/MDH1/ALDH9A1/ALDH7A1/ADH5/ME1/PKM/PCK2/AKR1A1/ALDH2/ME3/ACACB/HAGH/LDHB/LDHC/LDHAL6B/FH/ACYP1/PDHB/DLAT/ADH1B/PDHA2/PC/GRHPR/ME2/ADH7	27
KEGG	hsa05010	Alzheimer disease	180/3397	384/8135	0.02153	0.08876	0.06294	TUBA1A/APH1B/WNT5A/CAPN2/UQCRC2/PTGS2/GAPDH/KLC1/TUBB6/MAP2K1/ULK2/ATG14/FAS/UQCR11/PSMA5/DVL2/TNF/PSMD11/NDUFA8/PSENEN/NFKB1/KRAS/APOE/GSK3B/PIK3R3/ATF4/LRP5/RELA/TUBB2A/CSNK2A2/NDUFC1/PPP3CB/ITPR1/GNAQ/NDUFB11/ATG101/PSMA1/PSMA4/INSR/IKBKG/MCU/NDUFS3/FZD9/NDUFA3/CDK5/CASP3/HRAS/SLC39A10/TUBB3/CASP8/PSMB1/IL1B/PSMC4/NDUFA11/AGER/ADRM1/FRAT2/FRAT1/ARAF/PSMD13/CSNK2B/ATG13/LRP1/WIPI1/SLC39A8/RAF1/PSMB3/CASP7/UQCR10/COX7C/SLC39A13/SLC39A1/EIF2S1/IL6/IRS2/SLC25A5/SLC39A7/BACE2/PSEN2/PSMB5/COX7A2L/PSMD6/CSNK1A1/NDUFA4/CSNK1E/RTN3/PSMC3/COX4I2/NDUFA1/MAPK8/TUBA1C/PSMC6/HSD17B10/PIK3CD/NRAS/IL1A/TUBA4A/ATG2B/MAP2K2/NDUFA10/VDAC2/NDUFB1/CYBB/NDUFB5/FZD5/UQCRQ/MAP3K5/SLC39A12/GRIN2C/VDAC1/FZD1/NDUFS1/DKK2/PLCB1/EIF2AK2/ULK1/FADD/ADAM17/TRAF2/ATP2A2/NDUFB8/FZD4/CALML3/TUBB4A/DVL1/WNT1/PSEN1/MAPK1/TUBAL3/PSMC1/NDUFB6/TUBB1/BAD/TUBA1B/PSMD8/PSMA2/KIF5B/KLC4/NDUFB3/FZD7/SDHA/WNT2B/PSMC5/KLC2/PSMC2/PSMB2/PSMD4/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/MTOR/APP/WNT6/RTN4/ERN1/SNCA/UQCRB/FZD2/WNT10A/NRBF2/NDUFB2/APH1A/CHUK/COX6C/PSMD1/WNT7A/WNT10B/PSMB4/KLC3/CACNA1F/NDUFS2/PSMD9/PSMD3/NDUFA7/FZD10/PIK3CB/MAPK9/COX7B	180
KEGG	hsa00051	Fructose and mannose metabolism	20/3397	33/8135	0.02226	0.09065	0.06428	HK3/FBP1/ENOSF1/AKR1B1/PFKFB3/PFKM/PFKP/TPI1/ALDOC/ALDOA/PMM2/PFKFB4/FPGT/KHK/PFKFB1/SORD/PFKFB2/AKR1B10/GMDS/PFKL	20
KEGG	hsa05205	Proteoglycans in cancer	100/3397	205/8135	0.02359	0.09494	0.06732	IGF1/FN1/EZR/TLR2/PTPN6/CDKN1A/MAPK12/WNT5A/ITGA5/STAT3/ITGB5/FLNA/MAP2K1/SMAD2/CD44/MYC/RRAS/FAS/TNF/PRKACB/SLC9A1/KRAS/GAB1/PIK3R3/HCLS1/ACTB/TGFB1/RDX/ITPR1/HGF/HIF1A/PAK1/MAPK13/CD63/TFAP4/TLR4/FZD9/IGF1R/VEGFA/CASP3/EIF4B/HRAS/PLCG2/ARAF/NUDT16L1/RAF1/CCND1/RAC1/PLAUR/PTK2/HPSE/MMP9/PIK3CD/PRKACA/NRAS/ITGA2/MAP2K2/GRB2/FZD5/CAMK2A/FZD1/PXN/FLNB/PPP1CC/CAMK2D/PPP1CA/VAV1/EGFR/CAV3/FZD4/WNT1/MDM2/MAPK1/MSN/MAPK11/RPS6KB2/PPP1CB/HBEGF/FZD7/WNT2B/IL12B/DROSHA/MMP2/MTOR/RHOA/WNT6/PDCD4/FZD2/MET/WNT10A/WNT7A/ROCK2/WNT10B/SMO/PRKCA/ERBB3/PTCH1/FZD10/PIK3CB/CAMK2B	100
KEGG	hsa05225	Hepatocellular carcinoma	83/3397	168/8135	0.02601	0.1034	0.07335	NQO1/CDKN1A/WNT5A/KEAP1/MAP2K1/SMAD2/MYC/MGST2/GSTP1/DVL2/HMOX1/KRAS/GSK3B/GAB1/TXNRD1/PIK3R3/LRP5/ACTB/CDK4/TGFB1/GADD45B/HGF/FZD9/IGF1R/HRAS/GSTO1/PLCG2/FRAT2/FRAT1/ARAF/SHC1/GSTA1/RAF1/CCND1/ARID1B/GSTM3/TCF7L1/CSNK1A1/MGST1/BAX/GSTM5/PIK3CD/NRAS/MAP2K2/GRB2/PBRM1/ARID2/FZD5/GSTM4/FZD1/NFE2L2/EGFR/FZD4/DVL1/WNT1/MGST3/PHF10/MAPK1/TCF7L2/DDB2/BAD/TGFB3/SMARCC2/RPS6KB2/RB1/FZD7/WNT2B/TERT/MTOR/WNT6/SHC3/FZD2/MET/WNT10A/BAK1/SMARCC1/WNT7A/ACTL6A/SHC4/WNT10B/PRKCA/FZD10/PIK3CB	83
KEGG	hsa05020	Prion disease	130/3397	273/8135	0.02693	0.1047	0.07426	FYN/RAC2/TUBA1A/MAPK12/SOD1/HSPA6/UQCRC2/KLC1/TUBB6/EGR1/UQCR11/PSMA5/TNF/PSMD11/PRKACB/NDUFA8/GSK3B/PIK3R3/ATF4/TUBB2A/CSNK2A2/NDUFC1/PPP3CB/CREB5/ITPR1/NDUFB11/PSMA1/PSMA4/NCF4/PRKCD/MAPK13/NCAM1/NCF2/MCU/NDUFS3/NCF1/RYR1/HSPA5/NDUFA3/CASP3/TUBB3/PSMB1/IL1B/PSMC4/CREB3L2/NDUFA11/CCL5/ADRM1/PSMD13/CSNK2B/CREB1/PSMB3/UQCR10/COX7C/RAC1/EIF2S1/IL6/SLC25A5/CREB3L4/PSMB5/COX7A2L/PSMD6/NDUFA4/PSMC3/COX4I2/NDUFA1/MAPK8/TUBA1C/BAX/PSMC6/PIK3CD/PRKACA/IL1A/TUBA4A/CREB3/NDUFA10/VDAC2/CYBA/NDUFB1/CYBB/NDUFB5/UQCRQ/GRIN2C/VDAC1/HSPA1L/NDUFS1/CAV3/NDUFB8/TUBB4A/MAPK1/TUBAL3/PSMC1/NDUFB6/TUBB1/BAD/TUBA1B/C1QC/PSMD8/PSMA2/MAPK11/KIF5B/KLC4/NDUFB3/SDHA/PSMC5/KLC2/PSMC2/PSMB2/PSMD4/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/UQCRB/NDUFB2/COX6C/PSMD1/PSMB4/KLC3/CACNA1F/NDUFS2/PSMD9/PSMD3/ATF6B/NDUFA7/PIK3CB/MAPK9/C7/COX7B	130
KEGG	hsa04932	Non-alcoholic fatty liver disease	77/3397	155/8135	0.02697	0.1047	0.07426	FOS/MAPK12/SOCS3/UQCRC2/ADIPOR1/FAS/UQCR11/TNF/NDUFA8/NFKB1/GSK3B/PIK3R3/ATF4/RELA/NDUFC1/TGFB1/NDUFB11/LEP/INSR/MAPK13/NDUFS3/CEBPA/NDUFA3/CASP3/CASP8/IL1B/NDUFA11/CASP7/UQCR10/COX7C/RAC1/EIF2S1/IL6/IRS2/COX7A2L/NDUFA4/PRKAG2/BCL2L11/COX4I2/NDUFA1/RXRA/MAPK8/BAX/PIK3CD/NR1H3/IL1A/MAP3K11/NDUFA10/NDUFB1/MLX/NDUFB5/UQCRQ/MAP3K5/NDUFS1/PPARA/TRAF2/NDUFB8/ADIPOR2/PRKAA1/NDUFB6/MAPK11/PRKAG1/NDUFB3/SDHA/NDUFS7/NDUFV2/SDHD/ERN1/UQCRB/NDUFB2/COX6C/NDUFS2/NDUFA7/PIK3CB/MAPK9/PRKAB1/COX7B	77
KEGG	hsa01230	Biosynthesis of amino acids	40/3397	75/8135	0.02785	0.1069	0.07583	TALDO1/PGK1/ARG2/PFKM/PFKP/GAPDH/PSPH/MTR/ALDH18A1/PGAM1/PKM/RPE/TPI1/TKT/NAGS/ALDOC/RPIA/ENO1/ALDOA/IDH1/ACO1/IDH2/SHMT2/CTH/ASNS/PRPS1/GOT2/PGK2/SHMT1/IDH3A/ENO2/TKTL2/PRPS1L1/BCAT2/PRPS2/PC/IDH3G/PFKL/PHGDH/MAT1A	40
KEGG	hsa04926	Relaxin signaling pathway	65/3397	129/8135	0.02845	0.108	0.07657	FOS/MAPK12/VEGFB/GNAI3/GNB1/GNB2/GNA15/MAP2K1/SMAD2/GNG5/PRKACB/NFKBIA/NFKB1/KRAS/PIK3R3/ATF4/RELA/GNG7/TGFB1/CREB5/ARRB1/COL4A2/MAPK13/VEGFA/HRAS/CREB3L2/ACTA2/SHC1/CREB1/RAF1/ADCY7/GNG2/CREB3L4/GNB3/ADCY1/MAPK8/MMP9/ADCY3/GNAI2/PIK3CD/PRKACA/NRAS/CREB3/MAP2K2/GRB2/MMP1/GNB4/PLCB1/EGFR/INSL3/MAPK1/MAP2K4/COL4A3/GNG11/MAPK11/GNG12/RXFP2/MMP2/PRKCZ/SHC3/SHC4/PRKCA/ATF6B/PIK3CB/MAPK9	65
KEGG	hsa04360	Axon guidance	89/3397	182/8135	0.02923	0.1097	0.07779	FYN/RAC2/DPYSL2/MYL12A/WNT5A/SEMA4B/LRIG2/GNAI3/SSH2/RRAS/LIMK2/EPHB2/KRAS/GSK3B/CXCL12/PIK3R3/PLXNB2/PPP3CB/NFATC3/PAK1/CFL2/PLXNC1/ROBO3/SEMA4A/NCK1/CDK5/HRAS/ABL1/SRGAP3/PAK2/SEMA4C/PLCG2/SEMA4D/EFNB1/RAF1/BMP7/RAC1/DCC/EPHA8/PTK2/RGS3/SEMA6B/SRGAP2/PLXNA1/NRP1/ABLIM3/SEMA3B/GNAI2/L1CAM/NFATC2/PIK3CD/NTNG2/CFL1/NRAS/UNC5B/SEMA5A/PARD6B/CAMK2A/MYL5/CAMK2D/UNC5C/MYL12B/SLIT2/SEMA5B/MAPK1/EPHB1/PLXNA3/SSH3/PLXNA2/ENAH/PRKCZ/SRGAP1/RHOA/EFNA2/MET/SSH1/ROCK2/BMPR1B/SMO/BOC/PRKCA/PTCH1/DPYSL5/PIK3CB/EFNA3/CAMK2B/BMPR2/ABLIM1/SLIT3	89
KEGG	hsa04670	Leukocyte transendothelial migration	58/3397	114/8135	0.02984	0.1107	0.07852	ITGAM/VASP/EZR/RAC2/MAPK12/MYL12A/RAP1B/GNAI3/ACTN4/F11R/VCL/CXCL12/PIK3R3/ACTB/CTNNA1/PTK2B/ITGAL/RASSF5/NCF4/ACTN1/MAPK13/CLDN2/NCF2/ITGA4/NCF1/CD99/CLDN7/PLCG2/RAP1A/RAC1/ITK/CDH5/PTK2/CTNNA3/CD99L2/MMP9/GNAI2/PIK3CD/CYBA/CYBB/RHOH/PXN/MYL5/CLDN23/MYL12B/VAV1/JAM3/MSN/MAPK11/CLDN18/TXK/MMP2/CLDN15/RHOA/ROCK2/PRKCA/CLDN6/PIK3CB	58
KEGG	hsa05152	Tuberculosis	88/3397	180/8135	0.03023	0.111	0.07868	MYD88/ITGAM/ATP6V0D2/VDR/NOD2/TLR1/TLR2/MAPK12/CLEC7A/BCL10/FCGR1A/ATP6AP1/NFYC/CTSD/MRC2/CLEC4E/FCGR3B/CTSS/CEBPG/STAT1/LAMP2/CEBPB/JAK2/LAMP1/TNF/CD74/ATP6V0C/NFKB1/RELA/IFNGR2/IRAK4/TGFB1/PPP3CB/MAPK13/CORO1A/TRAF6/TCIRG1/TLR4/HLA-DPB1/HLA-DPA1/CD209/FCGR2C/CASP3/CASP8/IL1B/HLA-DMB/RFX5/CREB1/TRADD/RAF1/HLA-DOB/IL6/HLA-DRA/CR1/HLA-DMA/SPHK1/PLK3/MAPK8/BCL2/BAX/RAB5C/RAB5A/IL1A/CAMK2A/CAMK2D/IFNGR1/IL18/FADD/CALML3/MAPK1/CYP27B1/BAD/TGFB3/IFNG/JAK1/MAPK11/FCGR2A/LBP/IL12B/RHOA/MALT1/TIRAP/RFXANK/IL23A/TLR6/HLA-DOA/CAMK2B/MAPK9	88
KEGG	hsa05332	Graft-versus-host disease	24/3397	42/8135	0.03156	0.1146	0.08126	FAS/TNF/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/IL1B/HLA-DMB/HLA-DOB/HLA-G/IL6/HLA-DRA/HLA-DMA/HLA-C/GZMB/IL1A/KIR2DL2/PRF1/HLA-A/IFNG/KIR2DL1/CD80/HLA-DOA	24
KEGG	hsa05340	Primary immunodeficiency	22/3397	38/8135	0.03251	0.1168	0.0828	IL2RG/CD40/TAP2/TAP1/PTPRC/IL7R/UNG/IKBKG/CD3D/RFX5/BLNK/LCK/ICOS/ADA/ORAI1/TNFRSF13B/DCLRE1C/CD4/TNFRSF13C/CD8A/CD3E/RFXANK	22
KEGG	hsa01523	Antifolate resistance	18/3397	30/8135	0.03344	0.1188	0.08421	ABCC5/FOLR2/TNF/NFKB1/RELA/IKBKG/IL1B/IL6/SHMT2/ATIC/SLC46A1/TYMS/SHMT1/DHFR/FPGS/ABCC3/ABCC4/CHUK	18
KEGG	hsa04935	Growth hormone synthesis, secretion and action	60/3397	119/8135	0.03378	0.1188	0.08421	IGF1/JUNB/FOS/MAPK12/SOCS3/STAT3/GNAI3/MAP2K1/STAT1/JAK2/PRKACB/KRAS/GSK3B/PIK3R3/ATF4/CREB5/ITPR1/GNAQ/MAPK13/HRAS/STAT5A/CREB3L2/PLCG2/SHC1/CREB1/CRK/RAF1/ADCY7/IRS2/CREB3L4/ADCY1/PTK2/MAPK8/ADCY3/GNAI2/PIK3CD/PRKACA/NRAS/CREB3/MAP2K2/GRB2/PLCB1/MAPK1/SOCS1/MAP2K4/MAPK11/MAP3K1/MTOR/GHRH/SHC3/GHR/SHC4/SOCS2/CACNA1F/PRKCA/GNA11/ATF6B/GHRL/PIK3CB/MAPK9	60
KEGG	hsa05133	Pertussis	40/3397	76/8135	0.03557	0.1212	0.08595	MYD88/ITGAM/FOS/MAPK12/IRF1/ITGA5/GNAI3/NLRP3/LY96/TNF/NFKB1/TICAM1/RELA/IRAK4/CFL2/MAPK13/TRAF6/TLR4/CASP3/IL1B/CASP7/SERPING1/IL6/MAPK8/GNAI2/CFL1/IL1A/CASP1/C1R/IRF8/CALML3/MAPK1/C1QC/MAPK11/IL12B/RHOA/TIRAP/IL23A/CXCL6/MAPK9	40
KEGG	hsa05212	Pancreatic cancer	40/3397	76/8135	0.03557	0.1212	0.08595	RAC2/CDKN1A/RALGDS/STAT3/MAP2K1/STAT1/SMAD2/NFKB1/KRAS/PIK3R3/PLD1/RELA/CDK4/TGFB1/GADD45B/IKBKG/VEGFA/ARHGEF6/ARAF/RAF1/CCND1/RAC1/MAPK8/BAX/PIK3CD/EGFR/PLD2/RALBP1/MAPK1/DDB2/BAD/TGFB3/JAK1/RPS6KB2/RB1/MTOR/BAK1/CHUK/PIK3CB/MAPK9	40
KEGG	hsa05220	Chronic myeloid leukemia	40/3397	76/8135	0.03557	0.1212	0.08595	CDKN1A/MAP2K1/MYC/CTBP2/NFKBIA/NFKB1/KRAS/PIK3R3/RELA/CDK4/TGFB1/GADD45B/IKBKG/HRAS/ABL1/STAT5A/ARAF/SHC1/CRK/RAF1/CCND1/BCR/HDAC2/BAX/PIK3CD/CDKN1B/NRAS/MAP2K2/GRB2/MDM2/MAPK1/DDB2/BAD/TGFB3/RB1/SHC3/BAK1/CHUK/SHC4/PIK3CB	40
KEGG	hsa05014	Amyotrophic lateral sclerosis	169/3397	364/8135	0.03678	0.1241	0.088	TUBA1A/MAPK12/PINK1/NXF1/SOD1/C9orf72/NUP62/NUP160/UQCRC2/KLC1/TUBB6/ULK2/NUP214/ALS2/ATG14/SQSTM1/UQCR11/PSMA5/TNF/PSMD11/NDUFA8/ALYREF/ATF4/GPX7/TUBB2A/ACTB/NDUFC1/PPP3CB/PFN1/NUP85/NXT1/MAP1LC3A/SEH1L/NDUFB11/ATG101/PSMA1/PSMA4/MAPK13/NRG1/MCU/NDUFS3/NUP43/HSPA5/HNRNPA1/FIG4/NDUFA3/CAT/CASP3/HNRNPA2B1/TUBB3/PSMB1/PSMC4/NDUFA11/ADRM1/GPX3/POM121/SRSF3/PSMD13/ATG13/WIPI1/CHCHD10/VAPB/RAB8A/PSMB3/UQCR10/COX7C/RAC1/EIF2S1/DNAL1/MAP1LC3C/ATXN2/PSMB5/COX7A2L/PSMD6/NDUFA4/SETX/PSMC3/ATXN2L/COX4I2/NDUFA1/UBQLN2/BCL2/TUBA1C/BAX/PSMC6/NUP88/RAB39B/DNAI2/FUS/DNAH17/TOMM40L/SRSF7/DCTN2/RAB5A/NUP107/CASP1/TUBA4A/DERL1/ATG2B/TOMM40/NDUFA10/NDUFB1/NDUFB5/UQCRQ/MAP3K5/GRIN2C/VDAC1/NXT2/NDUFS1/ULK1/DNAL4/NUP93/TRAF2/NDUFB8/TUBB4A/NUP205/TUBAL3/SMCR8/PSMC1/DNAI1/NDUFB6/TUBB1/BAD/TUBA1B/PSMD8/PSMA2/NUP50/MAPK11/KIF5B/KLC4/HNRNPA3/NDUFB3/SDHA/PSMC5/OPTN/KLC2/PSMC2/GPX1/PSMB2/PSMD4/DNAH10/VCP/NDUFS7/NDUFV2/ND4/SDHD/MTOR/ERN1/UQCRB/SIGMAR1/NRBF2/NDUFB2/DCTN6/COX6C/PSMD1/PSMB4/DCTN5/KLC3/DAXX/DNAH8/NDUFS2/TARDBP/GRIA2/DNAH2/PSMD9/PSMD3/POM121C/NDUFA7/COX7B	169
KEGG	hsa01232	Nucleotide metabolism	44/3397	85/8135	0.0391	0.1293	0.09169	TYMP/LACC1/PNP/UPP1/NTPCR/AK3/ENTPD1/AK2/GMPS/DGUOK/NT5C/ADK/GUK1/IMPDH1/CTPS2/AK8/CMPK1/TK1/CMPK2/ASMTL/NME3/NME4/GMPR2/NME1/TYMS/RRM2/AMPD2/ADA/DCK/UCK1/TK2/RRM2B/AK6/DCTD/CTPS1/CDA/DCTPP1/UCKL1/NT5C3A/NT5M/UPP2/AMPD3/DUT/NUDT16	44
KEGG	hsa04012	ErbB signaling pathway	44/3397	85/8135	0.0391	0.1293	0.09169	CDKN1A/MAP2K1/MYC/KRAS/GSK3B/GAB1/PIK3R3/CBLB/PAK1/NRG1/NCK1/HRAS/ABL1/STAT5A/PAK2/PLCG2/ARAF/SHC1/CRK/RAF1/PTK2/MAPK8/PIK3CD/CDKN1B/NRAS/MAP2K2/GRB2/CAMK2A/CAMK2D/EGFR/ABL2/MAPK1/MAP2K4/BAD/RPS6KB2/HBEGF/MTOR/SHC3/SHC4/PRKCA/ERBB3/PIK3CB/CAMK2B/MAPK9	44
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	27/3397	49/8135	0.04053	0.1327	0.09412	HK3/HEXB/NANP/PGM3/GNPDA1/NPL/CYB5R1/CYB5R4/GALE/HEXA/GALK1/UAP1/NAGK/RENBP/PMM2/GPI/FPGT/GNPNAT1/PGM2/GALT/CYB5R3/CMAS/UAP1L1/GFPT1/GNE/GFPT2/GMDS	27
KEGG	hsa05222	Small cell lung cancer	47/3397	92/8135	0.04359	0.1404	0.09955	FN1/CDKN1A/PTGS2/BIRC2/LAMB2/MYC/FHIT/NFKBIA/SKP2/NFKB1/PIK3R3/RELA/CDK4/GADD45B/LAMC3/COL4A2/TRAF6/IKBKG/LAMB3/TRAF3/CDKN2B/CASP3/CCND1/PTK2/RXRA/CCNE1/BCL2/BAX/PIK3CD/CDKN1B/BIRC3/ITGA2/BIRC7/ITGA3/TRAF1/TRAF2/LAMA2/DDB2/COL4A3/TRAF5/RB1/BAK1/CHUK/TRAF4/XIAP/PIK3CB/LAMA1	47
KEGG	hsa04940	Type I diabetes mellitus	24/3397	43/8135	0.04371	0.1404	0.09955	FAS/TNF/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/IL1B/HLA-DMB/HLA-DOB/HLA-G/HLA-DRA/HLA-DMA/HLA-C/GZMB/IL1A/PTPRN2/ICA1/PRF1/HLA-A/IFNG/IL12B/CD80/HLA-DOA	24
KEGG	hsa05219	Bladder cancer	23/3397	41/8135	0.04475	0.1412	0.1001	TYMP/CDKN1A/MAP2K1/MYC/KRAS/CDK4/VEGFA/HRAS/ARAF/DAPK1/RAF1/CCND1/MMP9/NRAS/MAP2K2/MMP1/EGFR/MDM2/MAPK1/HBEGF/RB1/MMP2/DAPK2	23
KEGG	hsa05100	Bacterial invasion of epithelial cells	40/3397	77/8135	0.04481	0.1412	0.1001	FN1/MAD2L2/DNM3/ITGA5/VCL/GAB1/ACTR2/PIK3R3/HCLS1/ACTB/CTNNA1/RHOG/CLTB/ARPC1A/SHC1/CRK/RAC1/ARPC1B/CLTCL1/PTK2/CTNNA3/ARPC5L/DNM1/DNM2/PIK3CD/ELMO3/ACTR3B/CD2AP/ACTR3/ELMO1/PXN/CAV3/ARPC4/ARPC2/RHOA/SHC3/MET/SHC4/ELMO2/PIK3CB	40
KEGG	hsa05216	Thyroid cancer	21/3397	37/8135	0.04672	0.1458	0.1034	CDKN1A/NCOA4/MAP2K1/MYC/TPM3/KRAS/GADD45B/HRAS/PAX8/CCND1/TCF7L1/RXRA/BAX/NRAS/MAP2K2/MAPK1/TCF7L2/CCDC6/DDB2/RET/BAK1	21
KEGG	hsa04510	Focal adhesion	96/3397	201/8135	0.0475	0.1469	0.1042	IGF1/FN1/FYN/VASP/RAC2/MYL12A/ITGA5/RAP1B/FLT1/CCND3/ITGB7/DIAPH1/CAPN2/VEGFB/ITGB5/SPP1/FLNA/MAP2K1/BIRC2/ACTN4/LAMB2/VCL/GSK3B/PIK3R3/CCND2/THBS3/ACTB/TLN1/HGF/PARVB/PAK1/LAMC3/COL4A2/ACTN1/ITGA4/ITGA7/PDGFC/LAMB3/IGF1R/VEGFA/HRAS/ITGA11/PAK2/RAP1A/SHC1/CRK/RAF1/CCND1/RAC1/PDGFB/PTK2/ZYX/MAPK8/BCL2/PIK3CD/BIRC3/TLN2/ITGA2/GRB2/PDGFA/VWF/ITGA3/RASGRF1/PXN/MYL5/FLNB/MYLK/PPP1CC/PPP1CA/MYL12B/VAV1/EGFR/CAV3/COL2A1/LAMA2/MAPK1/COL4A3/TNXB/BAD/ITGA8/PPP1CB/COL6A3/RELN/PIP5K1B/RHOA/IBSP/SHC3/MET/XIAP/ROCK2/SHC4/PRKCA/PDGFD/PIK3CB/MAPK9/LAMA1	96
KEGG	hsa00531	Glycosaminoglycan degradation	12/3397	19/8135	0.04935	0.1512	0.1072	HEXB/NAGLU/IDS/HEXA/ARSB/SGSH/HYAL2/GNS/IDUA/GUSB/HPSE/HYAL3	12
KEGG	hsa04920	Adipocytokine signaling pathway	36/3397	69/8135	0.05138	0.156	0.1106	SOCS3/STAT3/ADIPOR1/ACSL5/JAK2/TNF/NFKBIA/NFKB1/RELA/CD36/PCK2/LEP/IKBKG/ACSL4/NFKBIB/ACACB/TRADD/IRS2/PPARGC1A/ACSL6/PRKAG2/RXRA/MAPK8/CPT1A/NFKBIE/PPARA/TRAF2/ADIPOR2/PRKAA1/PRKAG1/MTOR/PRKCQ/CHUK/G6PC/MAPK9/PRKAB1	36
KEGG	hsa00600	Sphingolipid metabolism	28/3397	52/8135	0.05219	0.157	0.1114	ASAH1/HEXB/SGMS2/CERS2/PSAP/DEGS1/HEXA/SGPL1/GALC/SGPP2/B4GALT6/CERS5/SPTLC2/GLA/CERS4/ENPP7/SPHK1/SGMS1/B4GALNT1/UGCG/ARSA/ACER3/KDSR/CERK/NEU1/SMPD1/SMPD2/DEGS2	28
KEGG	hsa05323	Rheumatoid arthritis	47/3397	93/8135	0.05324	0.1588	0.1126	ATP6V0D2/FOS/TLR2/ACP5/ATP6AP1/FLT1/ATP6V1C1/CTSK/IL15/TNF/ATP6V0C/CXCL12/TGFB1/ITGAL/TNFSF13B/TCIRG1/TLR4/HLA-DPB1/HLA-DPA1/VEGFA/ATP6V1A/IL1B/CCL5/HLA-DMB/TNFRSF11A/ATP6V1G3/HLA-DOB/ATP6V1B2/IL6/HLA-DRA/CTLA4/HLA-DMA/ATP6V1D/ATP6V0E2/MMP3/IL1A/MMP1/ATP6V1G2/IL18/CCL20/TGFB3/IFNG/CD80/ATP6V1B1/IL23A/HLA-DOA/CXCL6	47
KEGG	hsa05202	Transcriptional misregulation in cancer	92/3397	193/8135	0.05411	0.1599	0.1134	IGF1/ITGAM/NFKBIZ/IL1R2/CDKN1A/SPI1/DUSP6/KLF3/FCGR1A/FLT1/ITGB7/BCL6/BCL2A1/CD40/ETV6/BIRC2/MYC/SLC45A3/PER2/CEBPB/LDB1/NUPR1/NFKB1/DOT1L/CCND2/REL/RELA/MAF/GADD45B/SIN3A/LMO2/HPGD/FLT3/CEBPA/IL2RB/IGF1R/PAX8/MITF/PML/TFE3/ETV5/IL6/CDK9/PTK2/ARNT2/ETV7/ATM/LYL1/HDAC2/NCOR1/RXRA/MMP9/BAX/FUS/ID2/MLF1/GZMB/CDKN1B/CDKN2C/BIRC3/MMP3/SPINT1/PDGFA/TRAF1/ASPSCR1/BCL11B/SS18L1/TLX3/ELK4/PTCRA/MDM2/CCNA1/DDB2/SS18/IL3/HOXA10/BMP2K/NR4A3/CCNA2/MEN1/MEIS1/CSF1R/CCNT1/PAX7/MET/PAX5/BAK1/ZBTB16/MPO/PBX3/WT1/MEF2C	92
KEGG	hsa04530	Tight junction	81/3397	169/8135	0.05935	0.1739	0.1233	VASP/EZR/MPP5/TUBA1A/MYL12A/PPP2CA/ARHGEF18/CD1C/ACTN4/F11R/CD1E/PRKACB/RAPGEF6/ACTR2/HCLS1/MYL6B/ACTB/CDK4/RDX/RAPGEF2/ACTN1/RAP2C/CLDN2/CLDN7/ARPC1A/ARHGEF2/CD1B/RAP1A/SYMPK/RAB8A/CCND1/RAC1/ARPC1B/MYL6/MYH9/ARPC5L/PRKAG2/MAPK8/PCNA/PPP2R2D/TUBA1C/NEDD4/PPP2R2B/MICALL2/PRKACA/TUBA4A/CD1D/CD1A/TJAP1/ACTR3B/YBX3/PARD6B/MAP3K5/ACTR3/CLDN23/PPP2R1B/RAB8B/MYL12B/JAM3/HSPA4/PRKAA1/TUBAL3/MSN/ARPC4/TUBA1B/PRKAG1/LLGL1/CLDN18/MAP3K1/ARPC2/PRKCZ/CLDN15/RHOA/AMOTL1/WAS/ROCK2/PPP2R2C/CLDN6/MAPK9/SYNPO/PRKAB1	81
KEGG	hsa04010	MAPK signaling pathway	136/3397	294/8135	0.063	0.183	0.1297	MYD88/IGF1/FOS/RPS6KA2/RAC2/DUSP1/MAPK12/DUSP6/STMN1/DUSP5/RAP1B/HSPA6/FLT1/JUND/VEGFB/RASGRP2/FLNA/DUSP10/RPS6KA3/KITLG/MAP2K1/RASGRP3/MYC/DUSP7/MAP3K8/RRAS/FAS/TNF/PRKACB/NFKB1/IL1RAP/KRAS/MAP3K4/DUSP3/ATF4/CACNA2D3/MAPKAPK3/RELA/IRAK4/TGFB1/TAOK3/PPP3CB/NFATC3/GADD45B/HGF/ARRB1/PAK1/RAPGEF2/HSPB1/MAPK7/SRF/INSR/MAPK13/PTPN7/TRAF6/NFKB2/IKBKG/FLT3LG/DUSP2/FLT3/PDGFC/IGF1R/RASA2/VEGFA/CASP3/HRAS/RELB/PAK2/IL1B/NLK/MAP3K12/RASGRP1/RAP1A/ARAF/CRK/TRADD/RAF1/IL1R1/RAC1/MAP4K2/MAP4K3/PDGFB/FGF1/DUSP4/MAPKAPK5/MAPK8/TAB1/MAPKAPK2/NFATC1/MAP3K6/PRKACA/NRAS/MAP4K1/IL1A/MAP2K2/GRB2/MAP3K11/PDGFA/MAP3K5/RASGRF1/HSPA1L/FLNB/EGFR/TRAF2/ELK4/MAPK1/MAP2K4/TGFB3/MKNK2/MAP3K13/CACNG6/MAPK11/MAP3K1/GNG12/MAP2K5/CACNB3/CSF1R/MAP4K4/EFNA2/MET/CHUK/CACNA2D4/FGF23/ECSIT/CACNA1H/DAXX/CACNA1F/PRKCA/ERBB3/RASGRP4/PDGFD/NTRK2/FGF6/MEF2C/EFNA3/MAPK9	136
KEGG	hsa05330	Allograft rejection	21/3397	38/8135	0.06427	0.1835	0.1301	CD40/FAS/TNF/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/HLA-DMB/HLA-DOB/HLA-G/HLA-DRA/HLA-DMA/HLA-C/GZMB/PRF1/HLA-A/IFNG/IL12B/CD80/HLA-DOA	21
KEGG	hsa05230	Central carbon metabolism in cancer	36/3397	70/8135	0.06427	0.1835	0.1301	SCO2/HK3/LDHA/PFKM/PFKP/MAP2K1/MYC/KRAS/PIK3R3/PGAM1/PKM/HIF1A/SLC7A5/FLT3/HRAS/IDH1/RAF1/LDHB/G6PD/IDH2/LDHC/LDHAL6B/PIK3CD/NRAS/PDK1/MAP2K2/PDHB/GLS/EGFR/PDHA2/MAPK1/RET/MTOR/MET/PFKL/PIK3CB	36
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	28/3397	53/8135	0.06762	0.1914	0.1357	SLC8A1/VDR/ATP2B4/DNM3/ATP1A1/RAB11A/PRKACB/GNAQ/CLTB/ATP1B2/CLTCL1/ATP1B3/DNM1/AP2A2/DNM2/ATP1B1/PRKACA/AP2S1/AP2A1/PLCB1/KL/SLC8A2/ATP1B4/FXYD2/AP2M1/ATP1A2/SLC8A3/PRKCA	28
KEGG	hsa00920	Sulfur metabolism	7/3397	10/8135	0.06889	0.192	0.1362	PAPSS1/IMPAD1/ETHE1/TST/MPST/SUOX/PAPSS2	7
KEGG	hsa00640	Propanoate metabolism	18/3397	32/8135	0.06957	0.192	0.1362	LDHA/ALDH6A1/DBT/ACADS/MCEE/ACOX1/ACACB/LDHB/MLYCD/LDHC/PCCB/LDHAL6B/EHHADH/SUCLG2/HADHA/ACOX3/BCKDHB/BCKDHA	18
KEGG	hsa04136	Autophagy - other	18/3397	32/8135	0.06957	0.192	0.1362	ATG4C/ATG7/PPP2CA/ATG3/ULK2/ATG101/ATG13/WIPI1/MLST8/ATG9A/ATG4B/ATG2B/IGBP1/GABARAPL1/ATG4D/ATG4A/MTOR/ATG12	18
KEGG	hsa00020	Citrate cycle (TCA cycle)	17/3397	30/8135	0.07125	0.1951	0.1383	MDH1/PCK2/ACLY/OGDH/IDH1/ACO1/IDH2/FH/PDHB/SUCLG2/DLAT/IDH3A/PDHA2/SDHA/PC/SDHD/IDH3G	17
KEGG	hsa03320	PPAR signaling pathway	38/3397	75/8135	0.07368	0.1974	0.14	SLC27A1/FABP4/OLR1/CYP27A1/PPARD/ACAA1/PLIN2/ACSL5/GK/ME1/SCP2/CPT2/HMGCS1/SCD/CD36/PCK2/ACADM/ACSL4/ME3/ACOX1/SLC27A2/ACOX2/FABP3/APOA5/ACSL6/RXRA/NR1H3/UBC/CPT1A/EHHADH/MMP1/UCP1/FABP5/PPARA/DBI/APOA1/ACOX3/FADS2	38
KEGG	hsa04910	Insulin signaling pathway	66/3397	137/8135	0.07428	0.1974	0.14	SH2B2/HK3/PRKAR2B/SOCS3/FBP1/TSC1/MAP2K1/FLOT1/PRKACB/KRAS/GSK3B/PIK3R3/CBLB/PCK2/PPP1R3E/INSR/GYS1/PPP1R3D/HRAS/ARAF/SHC1/ACACB/CRK/RAF1/PHKB/EIF4E2/IRS2/PPARGC1A/FLOT2/PHKG1/PRKAG2/MAPK8/PIK3CD/PPP1R3B/RHOQ/TRIP10/PRKACA/NRAS/PPP1R3F/MAP2K2/GRB2/PPP1CC/PPP1CA/CALML3/PRKAA1/MAPK1/SOCS1/BAD/MKNK2/EIF4E/PYGM/PRKAG1/RPS6KB2/PPP1CB/PYGL/PRKCZ/MTOR/SHC3/SHC4/SOCS2/INPPL1/G6PC/INPP5A/PIK3CB/MAPK9/PRKAB1	66
KEGG	hsa05210	Colorectal cancer	43/3397	86/8135	0.07446	0.1974	0.14	FOS/RAC2/CDKN1A/RALGDS/PMAIP1/MAP2K1/SMAD2/MYC/KRAS/GSK3B/PIK3R3/TGFB1/GADD45B/CASP3/HRAS/ARAF/RAF1/CCND1/RAC1/DCC/TCF7L1/BCL2L11/MAPK8/MLH1/BCL2/BAX/PIK3CD/NRAS/MAP2K2/GRB2/EGFR/MAPK1/TCF7L2/DDB2/BAD/TGFB3/RPS6KB2/MTOR/RHOA/BAK1/APPL1/PIK3CB/MAPK9	43
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	14/3397	24/8135	0.07564	0.1974	0.14	HS3ST2/EXTL2/NDST2/HS2ST1/EXT2/EXT1/XYLT1/B3GALT6/GLCE/XYLT2/NDST1/HS3ST1/HS3ST3B1/B3GAT3	14
KEGG	hsa04110	Cell cycle	61/3397	126/8135	0.07614	0.1974	0.14	CDKN2D/CDKN1A/MAD2L2/CCND3/CUL1/MCM6/SMAD2/YWHAH/MYC/MCM2/SKP2/GSK3B/CCND2/CDK4/TGFB1/GADD45B/ORC5/CDKN2B/SFN/ABL1/CCNH/CDKN1C/CCND1/CDC23/ESPL1/ATM/ANAPC5/BUB3/HDAC2/CCNE1/PCNA/ORC6/ANAPC7/CDKN1B/CDKN2C/CDC25A/YWHAQ/ORC4/E2F4/CDC26/ATR/MCM5/MDM2/CCNA1/YWHAE/SMC3/WEE1/ANAPC4/TGFB3/RBL2/CDC27/CDC20/RB1/CCNA2/STAG1/YWHAG/ORC3/ANAPC11/RBX1/ANAPC13/CCNB3	61
KEGG	hsa01524	Platinum drug resistance	37/3397	73/8135	0.07644	0.1974	0.14	CDKN1A/PMAIP1/BIRC2/MGST2/GSTP1/FAS/PIK3R3/CASP3/CASP8/GSTO1/GSTA1/ATP7B/GSTM3/ATM/POLH/MGST1/MLH1/BCL2/BAX/ERCC1/GSTM5/PIK3CD/BIRC3/TOP2B/GSTM4/MAP3K5/BRCA1/FADD/MGST3/MDM2/MAPK1/BAD/ATP7A/BAK1/XIAP/TOP2A/PIK3CB	37
KEGG	hsa04115	p53 signaling pathway	37/3397	73/8135	0.07644	0.1974	0.14	IGF1/CDKN1A/CCND3/TNFRSF10A/PMAIP1/SIAH1/SHISA5/FAS/AIFM2/CCND2/CDK4/GADD45B/STEAP3/CD82/CCNG1/CASP3/SFN/PPM1D/CASP8/GORAB/CCND1/ATM/CCNE1/BCL2/EI24/BAX/SERPINE1/RRM2/TNFRSF10B/ATR/RRM2B/SESN1/MDM2/DDB2/SIVA1/CCNG2/SESN2	37
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	104/3397	223/8135	0.07693	0.1974	0.14	NQO1/EPHX1/FOS/MAPK12/SOD1/UQCRC2/KEAP1/MAP2K1/MGST2/UQCR11/NDUFA8/NFKBIA/HMOX1/AKR1C3/NFKB1/KRAS/PIK3R3/PLD1/RELA/NDUFC1/CYP1B1/HGF/HIF1A/NDUFB11/AKR1A1/PRKCD/MAPK13/NCF2/IKBKG/NDUFS3/NCF1/AKR1C1/VEGFA/NDUFA3/CAT/HRAS/ABL1/GSTO1/NDUFA11/ARAF/AHR/GSTA1/RAF1/UQCR10/COX7C/RAC1/SLC25A5/GSTM3/COX7A2L/PTK2/NDUFA4/COX4I2/NDUFA1/MGST1/CYP1A2/MAPK8/PRKD2/GSTM5/PIK3CD/NRAS/AS3MT/MAP2K2/GRB2/NDUFA10/VDAC2/CYBA/NDUFB1/NDUFB5/GSTM4/UQCRQ/MAP3K5/ARNT/VDAC1/NFE2L2/NDUFS1/EGFR/ABL2/NDUFB8/PLD2/MGST3/MAPK1/MAP2K4/NDUFB6/BAD/MAPK11/NDUFB3/SDHA/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/UQCRB/MET/NDUFB2/CHUK/COX6C/NDUFS2/FOXO3/NDUFA7/PIK3CB/PTPRJ/MAPK9/COX7B	104
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/3397	20/8135	0.07742	0.1974	0.14	CHSY1/CHST13/CSGALNACT1/XYLT1/CHST11/B3GALT6/CHST14/XYLT2/CSGALNACT2/CHST12/B3GAT3/CHST7	12
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	63/3397	131/8135	0.0824	0.2085	0.1479	FYN/ICAM2/RAC2/SH3BP2/PTPN6/TNFRSF10A/FCGR3B/MAP2K1/IFNAR1/FAS/TNF/KRAS/PIK3R3/LCP2/IFNGR2/PPP3CB/PAK1/PTK2B/ITGAL/HLA-E/HLA-B/CASP3/HRAS/TNFSF10/PLCG2/ARAF/SHC1/RAF1/TYROBP/HLA-G/RAC1/LCK/HLA-C/NFATC1/CD247/NFATC2/PIK3CD/GZMB/NRAS/MAP2K2/GRB2/ULBP2/TNFRSF10B/IFNGR1/VAV1/KIR2DL2/PRF1/MAPK1/HLA-A/IFNG/KIR2DL1/NCR3/KIR2DS1/IFNAR2/SH2D1A/MICA/NCR1/SHC3/CD244/SHC4/PRKCA/LAT/PIK3CB	63
KEGG	hsa05131	Shigellosis	114/3397	247/8135	0.08775	0.2204	0.1563	MYD88/HK3/MAPK12/MYL12A/ARF6/BCL10/ITGA5/DIAPH1/CAPN2/CYTH4/CUL1/NLRP3/ACTN4/ATG14/SQSTM1/CD44/CYTH1/VCL/UBE2N/TNF/NFKBIA/NFKB1/GSK3B/ACTR2/PIK3R3/RELA/HCLS1/ACTB/TLN1/ITPR1/PFN1/MAP1LC3A/TLR5/PRKCD/UBE2D3/CAST/TAB3/ACTN1/MAPK13/TRAF6/IKBKG/TLR4/UBE2D2/NFKBIB/IL1B/ARPC1A/CCL5/PLCG2/ARHGEF2/U2AF1/RRAGD/WIPI1/CRK/TRADD/RBCK1/IL1R1/RAC1/ARPC1B/MAP1LC3C/GLMN/PTK2/ATM/ARF1/ARPC5L/MAPK8/TAB1/BCL2/TNIP1/BAX/CBX3/UBE2D4/PIK3CD/TLN2/CASP1/UBC/AKT1S1/ACTR3B/FOXO4/RRAGA/ACTR3/VDAC1/PLCD1/ELMO1/PXN/MYL5/PLCB1/MYL12B/EGFR/U2AF1L4/IL18/TRAF2/CASP4/PLCD4/MDM2/MAPK1/TIFA/ARPC4/TRAF5/MAPK11/RPS6KB2/ARPC2/MTOR/PRKCQ/RHOA/RBX1/MALT1/CHUK/ROCK2/CAPNS1/FOXO3/ELMO2/PIK3CB/ATG12/MAPK9	114
KEGG	hsa05110	Vibrio cholerae infection	26/3397	50/8135	0.09257	0.2307	0.1636	ATP6V0D2/ATP6AP1/ATP6V1C1/PRKACB/ATP6V0C/ACTB/SEC61B/TCIRG1/ATP6V1A/PLCG2/ATP6V1G3/ATP6V1B2/ATP6V1D/ARF1/SLC12A2/KDELR3/ADCY3/ATP6V0E2/PRKACA/KDELR2/KCNQ1/ATP6V1G2/SEC61G/ATP6V1B1/SEC61A2/PRKCA	26
KEGG	hsa03410	Base excision repair	18/3397	33/8135	0.09489	0.2348	0.1665	NEIL2/UNG/PARP2/POLD4/POLD2/HMGB1/TDG/PCNA/XRCC1/PARP3/POLL/POLD1/LIG3/POLB/POLE4/FEN1/MBD4/SMUG1	18
KEGG	hsa05223	Non-small cell lung cancer	36/3397	72/8135	0.09662	0.2373	0.1683	CDKN1A/STAT3/MAP2K1/EML4/ALK/FHIT/KRAS/PIK3R3/CDK4/GADD45B/HGF/RASSF5/HRAS/STAT5A/PLCG2/ARAF/RAF1/CCND1/RXRA/BAX/PIK3CD/NRAS/MAP2K2/GRB2/EGFR/MAPK1/DDB2/BAD/RET/KIF5B/RB1/MET/BAK1/PRKCA/FOXO3/PIK3CB	36
KEGG	hsa00052	Galactose metabolism	17/3397	31/8135	0.09802	0.239	0.1695	HK3/AKR1B1/MGAM/PFKM/PFKP/GALM/GALE/GALK1/GLA/PGM2/LCT/GALT/AKR1B10/GAA/B4GALT1/PFKL/G6PC	17
KEGG	hsa04151	PI3K-Akt signaling pathway	160/3397	354/8135	0.09936	0.2405	0.1705	IGF1/IL2RG/FN1/TLR2/CDKN1A/PPP2CA/TSC1/ITGA5/FLT1/CCND3/ITGB7/VEGFB/ITGB5/SPP1/GNB1/GNB2/KITLG/MAP2K1/LAMB2/YWHAH/MYC/IL4R/GNG5/JAK2/IFNAR1/NFKB1/KRAS/GSK3B/PIK3R3/CCND2/THBS3/ATF4/IL7R/RELA/GNG7/CDC37/CDK4/CREB5/HGF/LPAR5/PPP2R3A/LPAR2/PCK2/LAMC3/IL3RA/COL4A2/INSR/GYS1/IKBKG/FLT3LG/ITGA4/MCL1/ITGA7/TLR4/FLT3/PDGFC/EPOR/LAMB3/IL2RB/IGF1R/VEGFA/EIF4B/HRAS/ITGA11/CREB3L2/PIK3R6/CRTC2/CREB1/IL7/RAF1/CCND1/EIF4E2/RAC1/LPAR6/IL6/MLST8/PDGFB/GNG2/FGF1/PPP2R5C/CREB3L4/GNB3/PTK2/BCL2L11/RXRA/CCNE1/BCL2/PPP2R2D/PPP2R2B/PIK3CD/CDKN1B/THEM4/NRAS/LPAR3/ITGA2/OSM/PPP2R3C/CREB3/MAP2K2/GRB2/PDGFA/YWHAQ/DDIT4/VWF/ITGA3/LPAR1/GNB4/CHRM2/F2R/PPP2R1B/BRCA1/EGFR/PKN2/COL2A1/HSP90B1/LAMA2/PRKAA1/MDM2/MAPK1/YWHAE/COL4A3/TNXB/BAD/GNG11/ITGA8/IL3/RBL2/EIF4E/JAK1/RPS6KB2/CSF3R/COL6A3/GNG12/HSP90AB1/PPP2R5B/PIK3CG/PHLPP2/YWHAG/IFNAR2/RELN/CSF1R/MTOR/IBSP/EFNA2/MET/CHUK/GHR/FGF23/PRKCA/ERBB3/G6PC/PPP2R2C/ATF6B/PDGFD/FOXO3/NTRK2/FGF6/PIK3CB/EFNA3/LAMA1	160
KEGG	hsa05016	Huntington disease	139/3397	306/8135	0.1029	0.2472	0.1753	TUBA1A/SOD1/UQCRC2/KLC1/TUBB6/ULK2/ATG14/UQCR11/PSMA5/PSMD11/NDUFA8/IFT57/GPX7/TUBB2A/NDUFC1/CREB5/SIN3A/ITPR1/GNAQ/NDUFB11/ATG101/PSMA1/PSMA4/NDUFS3/NDUFA3/CASP3/TUBB3/CASP8/PSMB1/PSMC4/CLTB/CREB3L2/NDUFA11/ADRM1/GPX3/PSMD13/ATG13/POLR2L/WIPI1/CREB1/PSMB3/UQCR10/COX7C/DNAL1/SLC25A5/PPARGC1A/POLR2H/CREB3L4/CLTCL1/PSMB5/COX7A2L/PSMD6/NDUFA4/PSMC3/HDAC2/COX4I2/NDUFA1/AP2A2/MAPK8/TUBA1C/TGM2/BAX/PSMC6/DNAI2/DNAH17/DCTN2/TUBA4A/ATG2B/CREB3/AP2S1/NDUFA10/VDAC2/NDUFB1/NDUFB5/POLR2F/UQCRQ/MAP3K5/POLR2D/UCP1/AP2A1/VDAC1/NDUFS1/PLCB1/ULK1/DNAL4/TBPL1/TRAF2/NDUFB8/TUBB4A/POLR2K/TUBAL3/PSMC1/DNAI1/NDUFB6/TUBB1/TUBA1B/TAF4/PSMD8/PSMA2/KIF5B/KLC4/NDUFB3/SDHA/PSMC5/KLC2/PSMC2/GPX1/AP2M1/POLR2J2/PSMB2/PSMD4/DNAH10/NDUFS7/TBP/NDUFV2/VDAC3/ND4/SDHD/MTOR/ERN1/UQCRB/NRBF2/NDUFB2/DCTN6/COX6C/PSMD1/POLR2I/PSMB4/DCTN5/KLC3/DNAH8/NDUFS2/GRIA2/DNAH2/PSMD9/PSMD3/NDUFA7/MAPK9/COX7B	139
KEGG	hsa04540	Gap junction	43/3397	88/8135	0.1061	0.253	0.1794	HTR2B/TUBA1A/GNAI3/TUBB6/MAP2K1/PRKACB/KRAS/TUBB2A/ITPR1/GNAQ/MAPK7/CSNK1D/PDGFC/ADRB1/HRAS/TUBB3/RAF1/ADCY7/PDGFB/ADCY1/ADCY3/GNAI2/TUBA1C/PRKACA/NRAS/TUBA4A/MAP2K2/GRB2/PDGFA/LPAR1/PLCB1/EGFR/TUBB4A/MAPK1/TUBAL3/TUBB1/TUBA1B/MAP2K5/GJD2/GJA1/PRKCA/GNA11/PDGFD	43
KEGG	hsa00380	Tryptophan metabolism	22/3397	42/8135	0.1076	0.2548	0.1807	ALDH3A2/ALDH9A1/IL4I1/HADH/ALDH7A1/CYP1B1/MAOA/CAT/IDO1/ALDH2/KYNU/HAAO/DHTKD1/CYP1A2/ALDH8A1/EHHADH/HADHA/TPH2/IDO2/MAOB/AOX1/TDO2	22
KEGG	hsa03060	Protein export	13/3397	23/8135	0.1107	0.2577	0.1828	IMMP1L/SEC62/SEC61B/HSPA5/IMMP2L/OXA1L/SPCS2/SRP14/SRP72/SRP68/SEC61G/SEC11A/SEC61A2	13
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	13/3397	23/8135	0.1107	0.2577	0.1828	MDH1/ATP1A1/PCK2/SLC25A10/ATP1B2/GLUD1/ATP1B3/GLUD2/ATP1B1/GLS/ATP1B4/FXYD2/ATP1A2	13
KEGG	hsa00260	Glycine, serine and threonine metabolism	21/3397	40/8135	0.1117	0.2577	0.1828	PSPH/ALDH7A1/PGAM1/MAOA/GATM/DAO/SHMT2/CTH/BHMT/GAMT/AGXT2/SHMT1/MAOB/AMT/SRR/ALAS1/GRHPR/GLYCTK/CHDH/PHGDH/PIPOX	21
KEGG	hsa05214	Glioma	37/3397	75/8135	0.1119	0.2577	0.1828	IGF1/CDKN1A/CAMK1D/MAP2K1/KRAS/PIK3R3/CDK4/GADD45B/IGF1R/HRAS/PLCG2/ARAF/SHC1/RAF1/CCND1/PDGFB/BAX/PIK3CD/NRAS/MAP2K2/GRB2/PDGFA/CAMK2A/CAMK2D/EGFR/CALML3/MDM2/MAPK1/DDB2/RB1/MTOR/SHC3/BAK1/SHC4/PRKCA/PIK3CB/CAMK2B	37
KEGG	hsa05012	Parkinson disease	121/3397	266/8135	0.117	0.2676	0.1898	DUSP1/TUBA1A/PINK1/SOD1/UQCRC2/GNAI3/KLC1/TUBB6/KEAP1/UCHL1/UQCR11/PSMA5/PSMD11/PRKACB/NDUFA8/ATF4/TUBB2A/NDUFC1/ITPR1/NDUFB11/PSMA1/PSMA4/MCU/NDUFS3/HTRA2/MAOA/HSPA5/NDUFA3/CASP3/UBE2L6/SLC39A10/TUBB3/PSMB1/PSMC4/NDUFA11/ADRM1/UBE2J1/PSMD13/SLC39A8/PSMB3/UQCR10/COX7C/SLC39A13/SLC39A1/EIF2S1/UBE2G2/SLC25A5/LRRK2/SLC39A7/PSMB5/COX7A2L/PSMD6/NDUFA4/PSMC3/COX4I2/NDUFA1/MAPK8/GNAI2/TUBA1C/BAX/PSMC6/PRKACA/TUBA4A/UBC/NDUFA10/VDAC2/NDUFB1/NDUFB5/UQCRQ/MAP3K5/CAMK2A/SLC39A12/VDAC1/NFE2L2/NDUFS1/CAMK2D/TXN/NDUFB8/CALML3/MAOB/TUBB4A/TUBAL3/PSMC1/NDUFB6/TUBB1/TUBA1B/PSMD8/PSMA2/KIF5B/KLC4/NDUFB3/SDHA/PSMC5/KLC2/UBE2G1/PSMC2/PSMB2/PSMD4/SNCAIP/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/ERN1/SNCA/UQCRB/NDUFB2/COX6C/PSMD1/UBA1/PSMB4/KLC3/DAXX/NDUFS2/PSMD9/PSMD3/NDUFA7/CAMK2B/MAPK9/COX7B	121
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/3397	11/8135	0.1223	0.278	0.1971	NQO1/COQ7/COQ5/COQ3/VKORC1/COQ6/GGCX	7
KEGG	hsa04922	Glucagon signaling pathway	51/3397	107/8135	0.1257	0.2837	0.2012	LDHA/FBP1/PFKM/PFKP/SIK1/PRKACB/PPP4C/PGAM1/ATF4/PKM/PPP3CB/CREB5/ITPR1/GNAQ/PCK2/GYS1/CREB3L2/SIK2/ACACB/CRTC2/CREB1/SIRT1/PHKB/LDHB/PPARGC1A/PHKG1/CREB3L4/LDHC/PRKAG2/LDHAL6B/PFKFB1/PRKACA/CREB3/CPT1A/PDHB/CAMK2A/CAMK2D/PLCB1/PPARA/CALML3/PRKAA1/PDHA2/PYGM/PRKAG1/PYGL/GCG/PRMT1/PFKL/G6PC/CAMK2B/PRKAB1	51
KEGG	hsa00240	Pyrimidine metabolism	29/3397	58/8135	0.1267	0.284	0.2014	TYMP/UPP1/ENTPD1/NT5C/CTPS2/DPYD/CMPK1/TK1/CMPK2/ASMTL/NME3/NME4/NME1/TYMS/RRM2/DCK/UCK1/TK2/RRM2B/DCTD/CTPS1/CAD/CDA/DCTPP1/UCKL1/NT5C3A/NT5M/UPP2/DUT	29
KEGG	hsa04215	Apoptosis - multiple species	17/3397	32/8135	0.1303	0.2901	0.2057	PMAIP1/BIRC2/HTRA2/CASP3/CASP8/CASP7/BCL2L11/MAPK8/BCL2/BAX/BIRC3/BIRC7/FADD/DIABLO/BAK1/XIAP/MAPK9	17
KEGG	hsa04630	JAK-STAT signaling pathway	75/3397	162/8135	0.1352	0.2991	0.2121	IL2RG/STAM/PTPN6/IL27RA/CDKN1A/SOCS3/STAT6/STAT3/PIM1/PTPN2/CCND3/IL13RA1/STAT1/MYC/IL4R/JAK2/IL15/IFNAR1/CISH/PIK3R3/CCND2/IL7R/IL21R/IFNGR2/CSF2RA/CSF2RB/IRF9/SOCS5/LEP/IL3RA/MCL1/IL20RB/EPOR/SOCS6/IL2RB/HRAS/STAT5A/IL7/RAF1/IL6ST/CCND1/IL6/SOCS7/PDGFB/IL15RA/BCL2/PIK3CD/TYK2/FHL1/IFNK/OSM/IL12RB1/GRB2/PDGFA/PIAS3/CNTF/IFNGR1/EGFR/IL13RA2/CNTFR/SOCS1/IL3/TSLP/IFNG/JAK1/CSF3R/IFNAR2/IL12B/MTOR/GHR/AOX1/SOCS2/IL23A/THPO/PIK3CB	75
KEGG	hsa04916	Melanogenesis	48/3397	101/8135	0.14	0.3076	0.2181	WNT5A/GNAI3/KITLG/MAP2K1/DVL2/PRKACB/KRAS/GSK3B/GNAQ/FZD9/HRAS/ASIP/CREB3L2/MITF/CREB1/RAF1/ADCY7/TCF7L1/CREB3L4/ADCY1/ADCY3/GNAI2/PRKACA/NRAS/CREB3/MAP2K2/FZD5/CAMK2A/FZD1/CAMK2D/PLCB1/DCT/FZD4/CALML3/DVL1/WNT1/MAPK1/TCF7L2/FZD7/WNT2B/WNT6/FZD2/WNT10A/WNT7A/WNT10B/PRKCA/FZD10/CAMK2B	48
KEGG	hsa03250	Viral life cycle - HIV-1	31/3397	63/8135	0.1413	0.3077	0.2182	MAP1S/ELL2/RAN/KAT2B/CHMP4B/MX2/BICD2/FURIN/SAMHD1/APOBEC3G/AFF4/ELL3/CDK9/APOBEC3C/CCR5/BICD1/SERINC3/TSG101/MX1/SUPT4H1/HGS/VPS4B/MAP1A/KAT2A/APOBEC3B/NELFCD/TNPO3/PIN1/CD4/CCNT1/CPSF7	31
KEGG	hsa04310	Wnt signaling pathway	77/3397	167/8135	0.1419	0.3077	0.2182	RAC2/WNT5A/CCND3/CUL1/PPARD/SIAH1/LGR4/MYC/CTBP2/DVL2/PRKACB/GSK3B/CCND2/LRP5/CSNK2A2/PPP3CB/NFATC3/DAAM1/TLE1/ROR2/CBY1/RUVBL1/FZD9/TLE4/NLK/FRAT2/FRAT1/SFRP4/CSNK2B/CCND1/RAC1/TCF7L1/CSNK1A1/CSNK1E/MAPK8/NFATC1/NFATC2/ROR1/PRKACA/TLE6/NKD2/FZD5/CAMK2A/FZD1/CACYBP/DKK2/CAMK2D/PLCB1/FZD4/DVL1/WNT1/PSEN1/RNF43/TCF7L2/LGR5/FOSL1/FZD7/WNT2B/TBL1X/LGR6/GPC4/RHOA/WNT6/FZD2/RBX1/WNT10A/WNT7A/SFRP5/ROCK2/WNT10B/CER1/DAAM2/PRKCA/CXXC4/FZD10/CAMK2B/MAPK9	77
KEGG	hsa04936	Alcoholic liver disease	66/3397	142/8135	0.1435	0.3086	0.2188	MYD88/ALDH3A2/TRA2B/MAPK12/IL17RA/ALDH9A1/ADIPOR1/LY96/ALDH7A1/ADH5/FAS/TNF/NFKBIA/NFKB1/GSK3B/TICAM1/RELA/IRAK4/SCD/TAB3/MAPK13/ACADM/TRAF6/IKBKG/TLR4/TRAF3/CASP3/CASP8/IL1B/ALDH2/ACOX1/ACACB/TRADD/SIRT1/CCND1/IL6/PPARGC1A/MLYCD/TCF7L1/C3AR1/PRKAG2/MAPK8/TAB1/CPT1A/ACADVL/MAP3K5/ADH1B/PPARA/FADD/ADIPOR2/PRKAA1/TCF7L2/MAP2K4/ACOX3/C1QC/MAPK11/PRKAG1/LBP/IL12B/TIRAP/CHUK/ADH7/IL17RC/FOXO3/MAPK9/PRKAB1	66
KEGG	hsa05226	Gastric cancer	69/3397	149/8135	0.1462	0.3086	0.2188	CDKN1A/WNT5A/MAP2K1/SMAD2/MYC/DVL2/KRAS/GSK3B/GAB1/PIK3R3/LRP5/TGFB1/GADD45B/HGF/CTNNA1/FZD9/CDKN2B/HRAS/FRAT2/FRAT1/ARAF/SHC1/MUC2/RAF1/CCND1/FGF1/TCF7L1/CSNK1A1/CTNNA3/RXRA/CCNE1/MLH1/BCL2/BAX/PIK3CD/CDKN1B/NRAS/MAP2K2/GRB2/FZD5/FZD1/EGFR/CDH17/FZD4/DVL1/WNT1/MAPK1/TCF7L2/DDB2/TGFB3/RPS6KB2/RB1/FZD7/WNT2B/TERT/MTOR/WNT6/SHC3/FZD2/MET/WNT10A/BAK1/WNT7A/SHC4/FGF23/WNT10B/FZD10/FGF6/PIK3CB	69
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	14/3397	26/8135	0.1464	0.3086	0.2188	PIGV/PIGP/PIGK/PIGN/PIGF/PIGB/GPAA1/PIGM/MPPE1/PIGQ/PIGO/PIGH/PIGT/PGAP1	14
KEGG	hsa00790	Folate biosynthesis	14/3397	26/8135	0.1464	0.3086	0.2188	GCH1/AKR1B1/PCBD1/AKR1C3/QDPR/MOCS2/PTS/SPR/ALPP/AKR1B10/DHFR/TPH2/FPGS/PCBD2	14
KEGG	hsa00513	Various types of N-glycan biosynthesis	20/3397	39/8135	0.1478	0.3086	0.2188	HEXB/MGAT2/DAD1/MAN1C1/HEXA/MGAT4B/MAN2A2/STT3A/ALG2/RPN2/STT3B/ALG12/MAN1B1/ALG13/MAN1A2/TUSC3/B4GALT1/ALG14/DDOST/ALG3	20
KEGG	hsa04810	Regulation of actin cytoskeleton	99/3397	218/8135	0.1493	0.3086	0.2188	ITGAM/FN1/EZR/RAC2/MYL12A/ITGA5/ITGB7/DIAPH1/SPATA13/ITGB5/SSH2/MAP2K1/ACTN4/VCL/RRAS/LIMK2/SLC9A1/IQGAP2/KRAS/ACTR2/CXCL12/PIK3R3/ITGAD/ACTB/RDX/PFN1/LPAR5/PAK1/LPAR2/CFL2/ITGAL/ACTN1/BAIAP2/ITGA4/ITGA7/PDGFC/DIAPH2/HRAS/CYFIP2/ITGA11/ARHGEF6/PAK2/ARPC1A/ARAF/CRK/RAF1/RAC1/ARPC1B/PDGFB/FGF1/CYFIP1/ITGAE/PTK2/MYH9/ARPC5L/PIK3CD/CFL1/NRAS/ITGA2/MAP2K2/ACTR3B/PDGFA/ITGA3/LPAR1/CHRM2/F2R/ACTR3/MOS/PXN/MYL5/MYLK/PPP1CC/PPP1CA/MYL12B/VAV1/EGFR/SCIN/MAPK1/GNA13/MSN/ARPC4/ITGA8/FGD3/SSH3/PPP1CB/BDKRB1/GNG12/ENAH/ARPC2/PIP5K1B/RHOA/SSH1/ARHGEF4/ROCK2/FGF23/NCKAP1/PDGFD/FGF6/PIK3CB	99
KEGG	hsa04622	RIG-I-like receptor signaling pathway	34/3397	70/8135	0.1494	0.3086	0.2188	MAPK12/IRF7/TNF/NFKBIA/CXCL10/NFKB1/RELA/MAPK13/TRAF6/IKBKG/DDX58/TRAF3/NFKBIB/CASP8/ISG15/TRADD/MAVS/CYLD/DDX3X/AZI2/IFIH1/MAPK8/OTUD5/IFNK/FADD/TRAF2/MAPK11/PIN1/MAP3K1/NLRX1/IL12B/CHUK/ATG12/MAPK9	34
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	50/3397	106/8135	0.1497	0.3086	0.2188	FOS/VDR/CDKN1A/MEF2A/NR4A2/JUND/GNAI3/MAP2K1/EGR1/PRKACB/AKAP13/PLD1/ATF4/LRP5/CREB5/ITPR1/ARRB1/GNAQ/PDE4B/CREB3L2/ARAF/CREB1/RAF1/ADCY7/CREB3L4/ADCY1/RXRA/BCL2/ADCY3/GNAI2/PRKACA/CREB3/MMP14/PLCB1/EGFR/PLD2/KL/MAPK1/GNA13/CYP27B1/PTHLH/HBEGF/RHOA/MMP16/GCM2/FGF23/PRKCA/GNA11/ATF6B/MEF2C	50
KEGG	hsa04370	VEGF signaling pathway	29/3397	59/8135	0.1531	0.3121	0.2213	RAC2/MAPK12/PTGS2/MAP2K1/KRAS/PIK3R3/MAPKAPK3/PPP3CB/HSPB1/MAPK13/VEGFA/HRAS/PLCG2/RAF1/RAC1/PTK2/SPHK1/MAPKAPK2/NFATC2/PIK3CD/NRAS/MAP2K2/PXN/MAPK1/BAD/MAPK11/SH2D2A/PRKCA/PIK3CB	29
KEGG	hsa01250	Biosynthesis of nucleotide sugars	19/3397	37/8135	0.1542	0.3121	0.2213	HK3/NANP/PGM3/GALE/GALK1/UAP1/NAGK/PMM2/GPI/FPGT/GNPNAT1/PGM2/GALT/CMAS/UAP1L1/GFPT1/GNE/GFPT2/GMDS	19
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	19/3397	37/8135	0.1542	0.3121	0.2213	IGF1/ATP1A1/KRAS/PIK3R3/NR3C2/INSR/SFN/KCNJ1/ATP1B2/ATP1B3/PIK3CD/ATP1B1/MAPK1/ATP1B4/FXYD2/ATP1A2/PRKCA/PIK3CB/SLC9A3R2	19
KEGG	hsa01212	Fatty acid metabolism	28/3397	57/8135	0.1594	0.3188	0.2261	HADHB/CBR4/HADH/ACAA1/ACSL5/ELOVL5/SCP2/CPT2/SCD/OXSM/ACADM/ACADS/ACSL4/ACOX1/TECR/HSD17B4/ELOVL7/ACADSB/ACSL6/CPT1A/EHHADH/ACADVL/HADHA/ACAA2/ACOX3/ELOVL6/FADS2/HSD17B12	28
KEGG	hsa05134	Legionellosis	28/3397	57/8135	0.1594	0.3188	0.2261	MYD88/ITGAM/TLR2/HSPA6/SEC22B/TNF/NFKBIA/NFKB1/RELA/SAR1B/TLR5/NFKB2/TLR4/CASP3/CASP8/IL1B/CASP7/IL6/CR1/SAR1A/ARF1/CASP1/EEF1A2/HSPA1L/IL18/IL12B/VCP/CLK1	28
KEGG	hsa04918	Thyroid hormone synthesis	36/3397	75/8135	0.1626	0.3232	0.2292	ATP1A1/PRKACB/GSR/ATF4/GPX7/CREB5/ITPR1/GNAQ/HSPA5/PAX8/CREB3L2/GPX3/CREB1/ATP1B2/ADCY7/CREB3L4/ADCY1/ATP1B3/ADCY3/ATP1B1/PRKACA/ASGR2/CREB3/CANX/SLC26A4/PLCB1/HSP90B1/ATP1B4/SERPINA7/FXYD2/GPX1/ASGR1/ATP1A2/PRKCA/ATF6B/ALB	36
KEGG	hsa04130	SNARE interactions in vesicular transport	17/3397	33/8135	0.1679	0.3316	0.2352	STX7/STX11/SEC22B/VAMP5/VAMP3/BET1/GOSR2/GOSR1/STX5/STX16/VTI1A/YKT6/STX18/VTI1B/STX8/VAMP1/SNAP29	17
KEGG	hsa04962	Vasopressin-regulated water reabsorption	22/3397	44/8135	0.1688	0.3316	0.2352	RAB11A/DYNC1LI1/PRKACB/ARHGDIA/CREB5/DYNLL2/ARHGDIB/CREB3L2/CREB1/CREB3L4/ADCY3/RAB5C/PRKACA/DCTN2/RAB5A/DYNC2LI1/CREB3/AQP3/DYNC1LI2/DCTN6/DCTN5/AVPR2	22
KEGG	hsa04934	Cushing syndrome	71/3397	155/8135	0.171	0.3322	0.2355	CDKN1A/WNT5A/RAP1B/GNAI3/MAP2K1/SCARB1/DVL2/PRKACB/WDR5B/GSK3B/ATF4/CDK4/CREB5/ITPR1/GNAQ/FZD9/CDKN2B/CREB3L2/LDLR/RAP1A/AHR/CREB1/CCND1/ADCY7/TCF7L1/CREB3L4/ADCY1/CCNE1/ADCY3/GNAI2/FH/CDKN1B/CDKN2C/PRKACA/CREB3/MAP2K2/KCNK2/FZD5/CAMK2A/ARNT/FZD1/CAMK2D/PLCB1/EGFR/ORAI1/FZD4/DVL1/WNT1/MAPK1/TCF7L2/NCEH1/RB1/KCNA4/FZD7/MEN1/WNT2B/PDE8A/WNT6/FZD2/WNT10A/WNT7A/WNT10B/CACNA1H/CACNA1F/GNA11/WDR5/PDE8B/ATF6B/FZD10/CAMK2B/AIP	71
KEGG	hsa00511	Other glycan degradation	10/3397	18/8135	0.171	0.3322	0.2355	FUCA1/HEXB/MANBA/HEXA/MAN2B1/AGA/FUCA2/NEU1/ENGASE/MAN2B2	10
KEGG	hsa04213	Longevity regulating pathway - multiple species	30/3397	62/8135	0.1751	0.3365	0.2386	IGF1/SOD1/HSPA6/PRKACB/KRAS/PIK3R3/INSR/IGF1R/CAT/HRAS/SIRT1/EIF4EBP2/ADCY7/IRS2/ADCY1/HDAC2/PRKAG2/ADCY3/PIK3CD/PRKACA/NRAS/AKT1S1/HSPA1L/PRKAA1/PRKAG1/RPS6KB2/MTOR/FOXO3/PIK3CB/PRKAB1	30
KEGG	hsa04710	Circadian rhythm	16/3397	31/8135	0.1753	0.3365	0.2386	BHLHE40/CUL1/PER2/CSNK1D/CREB1/FBXL3/CSNK1E/PRKAG2/CLOCK/PRKAA1/RORA/ARNTL/PRKAG1/PER3/RBX1/PRKAB1	16
KEGG	hsa05213	Endometrial cancer	28/3397	58/8135	0.19	0.3626	0.2571	CDKN1A/MAP2K1/MYC/KRAS/GSK3B/PIK3R3/GADD45B/CTNNA1/HRAS/ARAF/RAF1/CCND1/TCF7L1/CTNNA3/MLH1/BAX/PIK3CD/NRAS/MAP2K2/GRB2/EGFR/MAPK1/TCF7L2/DDB2/BAD/BAK1/FOXO3/PIK3CB	28
KEGG	hsa04966	Collecting duct acid secretion	14/3397	27/8135	0.1916	0.3637	0.2579	ATP6V0D2/ATP6V1C1/ATP6V0C/TCIRG1/ATP6V1A/ATP4A/ATP6V1G3/ATP6V1B2/ATP6V1D/ATP6V0E2/ATP6V1G2/SLC4A1/SLC12A7/ATP6V1B1	14
KEGG	hsa03040	Spliceosome	67/3397	147/8135	0.1937	0.3654	0.2591	TRA2B/SRSF5/HSPA6/PRPF4/PRPF38A/U2SURP/ALYREF/PPIL1/MAGOHB/PCBP1/RP9/SRSF10/LSM5/CRNKL1/HNRNPK/SYF2/SNRNP200/HNRNPA1/RBM8A/SNRPB/TXNL4A/U2AF1/SRSF3/SNRPA1/BCAS2/BUD31/DHX8/LSM7/SNRPD1/PRPF3/SNRPA/PUF60/SNRPC/ISY1/SNRPB2/HNRNPC/PRPF40B/PRPF40A/FUS/THOC2/SRSF6/SNRPF/SRSF7/DDX46/CDC40/PRPF8/SF3A3/SMNDC1/SF3B4/HNRNPM/HSPA1L/PRPF31/U2AF1L4/SART1/SRSF4/WBP11/RBM25/DHX38/HNRNPA3/PRPF19/CCDC12/AQR/CHERP/DHX16/EFTUD2/SNRPG/SNRPD2	67
KEGG	hsa03030	DNA replication	18/3397	36/8135	0.201	0.3771	0.2674	MCM6/RNASEH2B/MCM2/RPA1/SSBP1/PRIM2/POLD4/POLD2/RFC3/RNASEH1/PCNA/MCM5/RNASEH2C/POLD1/POLA1/POLA2/POLE4/FEN1	18
KEGG	hsa05415	Diabetic cardiomyopathy	91/3397	203/8135	0.2041	0.3771	0.2674	RAC2/PDK4/MAPK12/CTSD/UQCRC2/GAPDH/SMAD2/UQCR11/NDUFA8/GSR/NFKB1/GSK3B/PIK3R3/RELA/PDK2/CPT2/NDUFC1/TGFB1/CD36/NDUFB11/NCF4/PRKCD/INSR/MAPK13/GYS1/NCF2/NDUFS3/NCF1/NDUFA3/NDUFA11/AGER/MPC2/UQCR10/COX7C/RAC1/SLC25A5/G6PD/COX7A2L/NDUFA4/COX4I2/NDUFA1/MAPK8/MMP9/PIK3CD/NDUFA10/PDHB/VDAC2/CYBA/NDUFB1/CYBB/NDUFB5/UQCRQ/CAMK2A/VDAC1/NDUFS1/PPP1CC/CAMK2D/PLCB1/PPP1CA/PPARA/ATP2A2/NDUFB8/CMA1/GFPT1/PDHA2/NDUFB6/TGFB3/MAPK11/PPP1CB/NDUFB3/SDHA/REN/MMP2/PRKCZ/NDUFS7/NDUFV2/VDAC3/ND4/SDHD/MTOR/GFPT2/UQCRB/NDUFB2/COX6C/NDUFS2/PRKCA/NDUFA7/PIK3CB/CAMK2B/MAPK9/COX7B	91
KEGG	hsa04137	Mitophagy - animal	34/3397	72/8135	0.2043	0.3771	0.2674	PINK1/SQSTM1/TBC1D15/RRAS/KRAS/ATF4/RELA/CSNK2A2/FIS1/HIF1A/MAP1LC3A/TFEB/HRAS/RHOT2/MITF/CSNK2B/TFE3/MAP1LC3C/CITED2/ATG9A/TBC1D17/MAPK8/NRAS/UBC/USP30/RAB7B/ULK1/TAX1BP1/GABARAPL1/OPTN/NBR1/FOXO3/MAPK9/FUNDC1	34
KEGG	hsa05218	Melanoma	34/3397	72/8135	0.2043	0.3771	0.2674	IGF1/CDKN1A/MAP2K1/KRAS/PIK3R3/CDK4/GADD45B/HGF/PDGFC/IGF1R/HRAS/MITF/ARAF/RAF1/CCND1/PDGFB/FGF1/BAX/PIK3CD/NRAS/MAP2K2/PDGFA/EGFR/MDM2/MAPK1/DDB2/BAD/RB1/MET/BAK1/FGF23/PDGFD/FGF6/PIK3CB	34
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	68/3397	150/8135	0.2078	0.3813	0.2704	SLC8A1/ATP2B4/MAPK12/PPP2CA/ATP1A1/GNAI3/TPM3/PRKACB/SLC9A1/ATF4/CACNA2D3/CREB5/GNAQ/PPP2R3A/MAPK13/SCN1B/ADRB1/ACTC1/CREB3L2/PIK3R6/CREB1/ATP1B2/ADCY7/PPP2R5C/CREB3L4/ADCY1/ATP1B3/CREM/TPM4/BCL2/ADCY3/GNAI2/PPP2R2D/TPM1/PPP2R2B/ATP1B1/PRKACA/ADRB2/PPP2R3C/CREB3/KCNQ1/CAMK2A/PPP1CC/CAMK2D/PLCB1/PPP1CA/PPP2R1B/ATP2A2/CALML3/SLC8A2/MAPK1/ATP1B4/ADRA1D/CACNG6/MAPK11/FXYD2/PPP1CB/PPP2R5B/PIK3CG/CACNB3/ATP1A2/SLC8A3/CACNA2D4/CACNA1F/PRKCA/PPP2R2C/ATF6B/CAMK2B	68
KEGG	hsa04072	Phospholipase D signaling pathway	67/3397	148/8135	0.2142	0.391	0.2772	FYN/ARF6/RALGDS/DNM3/TSC1/DGKA/CYTH4/KITLG/MAP2K1/CYTH1/RRAS/KRAS/GAB1/PIK3R3/PLD1/LPAR5/DGKD/LPAR2/PTK2B/INSR/PDGFC/HRAS/AGPAT3/PLCG2/SHC1/PIK3R6/RAF1/ADCY7/LPAR6/CXCR1/PDGFB/AGPAT4/ADCY1/ARF1/SPHK1/FCER1A/DNM1/ADCY3/DNM2/PIK3CD/NRAS/LPAR3/MAP2K2/GRB2/PDGFA/LPAR1/F2R/PLCB1/EGFR/CXCR2/AGPAT5/PLD2/MAPK1/GNA13/DGKG/PIK3CG/AGPAT1/MTOR/PIP5K1B/RHOA/SHC3/AGPAT2/SHC4/PRKCA/AVPR2/PDGFD/PIK3CB	67
KEGG	hsa04514	Cell adhesion molecules	67/3397	149/8135	0.2359	0.4281	0.3036	ITGAM/ICAM2/SELL/VCAN/ICAM3/CD58/ITGB7/CD40/CD2/ALCAM/F11R/PTPRC/CD22/CD226/ITGAL/CLDN2/HLA-F/NCAM1/ITGA4/CD99/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/CLDN7/HLA-DMB/ICOSLG/HLA-DOB/HLA-G/HLA-DRA/CDH5/CTLA4/HLA-DMA/HLA-C/SELPLG/TIGIT/PDCD1LG2/CD99L2/L1CAM/NTNG2/MPZL1/PVR/MADCAM1/CD274/ICOS/CLDN23/CD276/JAM3/ITGA8/HLA-A/CLDN18/CD34/CD4/GLG1/CD80/SIGLEC1/CLDN15/SDC3/CADM3/CDH3/CD8A/PDCD1/NLGN2/CNTN1/HLA-DOA/CLDN6/PTPRM	67
KEGG	hsa00650	Butanoate metabolism	14/3397	28/8135	0.2425	0.4349	0.3084	HADH/HMGCL/ACSM5/AACS/HMGCS1/ACADS/BDH1/BDH2/ALDH5A1/OXCT1/EHHADH/HADHA/L2HGDH/HMGCLL1	14
KEGG	hsa05224	Breast cancer	66/3397	147/8135	0.243	0.4349	0.3084	IGF1/FOS/DLL1/CDKN1A/NOTCH2/WNT5A/MAP2K1/MYC/DVL2/KRAS/GSK3B/PIK3R3/NOTCH3/LRP5/CDK4/GADD45B/NCOA3/NFKB2/FZD9/IGF1R/HRAS/FRAT2/FRAT1/ARAF/SHC1/HEY1/RAF1/CCND1/FGF1/TCF7L1/CSNK1A1/BAX/PIK3CD/NRAS/MAP2K2/GRB2/FZD5/HES1/FZD1/BRCA1/EGFR/FZD4/HEY2/DVL1/WNT1/MAPK1/TCF7L2/DDB2/NOTCH4/RPS6KB2/RB1/FZD7/WNT2B/MTOR/WNT6/SHC3/FZD2/WNT10A/BAK1/WNT7A/SHC4/FGF23/WNT10B/FZD10/FGF6/PIK3CB	66
KEGG	hsa00450	Selenocompound metabolism	9/3397	17/8135	0.2435	0.4349	0.3084	SEPHS2/MTR/PAPSS1/SEPSECS/TXNRD1/PSTK/PAPSS2/CTH/MARS2	9
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	8/3397	15/8135	0.2565	0.4557	0.3231	HEXB/HEXA/ST3GAL2/GLA/NAGA/ST3GAL1/B3GALT5/ST8SIA1	8
KEGG	hsa00330	Arginine and proline metabolism	24/3397	51/8135	0.2638	0.4661	0.3305	SMS/ALDH3A2/ARG2/ALDH9A1/LAP3/ALDH7A1/SAT1/ALDH18A1/MAOA/ODC1/ALDH2/GATM/ALDH4A1/DAO/L3HYPDH/CNDP2/GAMT/GOT2/MAOB/SRM/AZIN2/AGMAT/P4HA1/CKMT2	24
KEGG	hsa03450	Non-homologous end-joining	7/3397	13/8135	0.2708	0.476	0.3375	XRCC5/XRCC4/LIG4/POLL/XRCC6/DCLRE1C/FEN1	7
KEGG	hsa01240	Biosynthesis of cofactors	68/3397	153/8135	0.2742	0.4795	0.34	NQO1/QPRT/ALDH3A2/GCH1/GCLM/MTHFD2/FECH/PANK2/NMNAT3/UROD/AK3/LIPT1/AK2/DHRS3/NFS1/ALAD/COQ7/COQ5/OXSM/PANK3/AKR1A1/PANK1/CTPS2/NMNAT1/IDO1/GCLC/CPOX/PHOSPHO2/AK8/NADK2/PMM2/ALDH2/CMPK1/RFK/TPK1/CMPK2/COQ3/MOCS2/PTS/RDH12/KYNU/HAAO/SPR/NME3/GUSB/SHMT2/NME4/MMAB/VKORC1/ALPP/NME1/GSS/COX15/COQ6/NMNAT2/FLAD1/GGCX/SHMT1/DHFR/IDO2/AK6/FPGS/ALAS1/CTPS1/CAD/BCAT2/TDO2/MAT1A	68
KEGG	hsa03018	RNA degradation	36/3397	79/8135	0.2811	0.4837	0.343	PFKM/PFKP/TOB1/DIS3L/BTG2/LSM5/XRN2/ENO1/DCP1B/DCP2/ZCCHC7/LSM7/BTG3/DCPS/BTG1/XRN1/EXOSC2/CNOT4/EDC4/EXOSC7/TTC37/CNOT7/ENO2/MPHOSPH6/EXOSC9/EXOSC3/CNOT10/EXOSC6/PNPT1/SKIV2L/EXOSC8/NUDT16/PFKL/C1D/PABPC4L/EXOSC5	36
KEGG	hsa00340	Histidine metabolism	11/3397	22/8135	0.2826	0.4837	0.343	ALDH3A2/ALDH9A1/ALDH7A1/HAL/HNMT/MAOA/ALDH2/CNDP2/MAOB/AMDHD1/ALDH3A1	11
KEGG	hsa00900	Terpenoid backbone biosynthesis	11/3397	22/8135	0.2826	0.4837	0.343	PCYOX1/HMGCR/HMGCS1/PDSS1/FDPS/RCE1/IDI1/ZMPSTE24/NUS1/DHDDS/ICMT	11
KEGG	hsa04912	GnRH signaling pathway	42/3397	93/8135	0.2853	0.4837	0.343	MAPK12/MAP2K1/EGR1/PRKACB/KRAS/MAP3K4/PLD1/ATF4/ITPR1/GNAQ/PTK2B/MAPK7/PRKCD/MAPK13/HRAS/RAF1/ADCY7/ADCY1/MAPK8/ADCY3/PRKACA/NRAS/MAP2K2/GRB2/MMP14/CAMK2A/CAMK2D/PLCB1/EGFR/CALML3/PLD2/MAPK1/MAP2K4/MAPK11/HBEGF/MAP3K1/MMP2/CACNA1F/PRKCA/GNA11/CAMK2B/MAPK9	42
KEGG	hsa00310	Lysine degradation	29/3397	63/8135	0.2855	0.4837	0.343	ALDH3A2/ALDH9A1/HADH/ALDH7A1/PHYKPL/SETDB2/EZH2/DOT1L/SUV39H2/NSD1/SETMAR/ALDH2/SETD7/PLOD1/SMYD3/DHTKD1/KMT2E/SUV39H1/ASH1L/PLOD2/SETDB1/EHHADH/HADHA/PRDM2/PRDM6/KMT2B/HYKK/EZH1/PIPOX	29
KEGG	hsa05217	Basal cell carcinoma	29/3397	63/8135	0.2855	0.4837	0.343	CDKN1A/WNT5A/DVL2/GSK3B/GADD45B/FZD9/BMP2/PTCH2/TCF7L1/BMP4/BAX/FZD5/FZD1/FZD4/DVL1/WNT1/TCF7L2/DDB2/FZD7/WNT2B/WNT6/FZD2/WNT10A/BAK1/WNT7A/WNT10B/SMO/PTCH1/FZD10	29
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	45/3397	100/8135	0.2867	0.4837	0.343	IL2RG/CCR2/CX3CR1/TNFRSF14/TNFRSF10A/PPBP/ACKR3/CXCL9/CXCL11/TNFRSF10D/TNF/CXCL10/CXCL12/IL18R1/CXCL13/IL20RB/IL2RB/TNFRSF10C/TNFSF10/CCL5/CCL7/IL6ST/CXCR1/IL6/CCR5/CCL13/CCL8/CCR6/CCR4/TNFRSF10B/CCR3/CXCR2/IL18/CCL20/CCL26/CSF1R/IL18RAP/CX3CL1/CXCR3/CCL19/CCL4/CCR7/CCL24/CXCL6/IL37	45
KEGG	hsa00564	Glycerophospholipid metabolism	44/3397	98/8135	0.2964	0.4966	0.3522	LPCAT2/PLD3/CDS1/PLA2G12A/CHPT1/DGKA/GPAM/MBOAT7/GPCPD1/CDS2/PTDSS2/MBOAT1/LYPLA2/LPGAT1/PNPLA6/PLD1/DGKD/PLA1A/PNPLA7/AGPAT3/PLA2G15/PLB1/CDIPT/AGPAT4/CRLS1/PLA2G3/MBOAT2/LCAT/ADPRM/CHKA/PLD4/AGPAT5/PLD2/PLA2G6/DGKG/GNPAT/AGPAT1/CHAT/TAZ/LPCAT1/CHKB/PGS1/AGPAT2/LPCAT3	44
KEGG	hsa00670	One carbon pool by folate	10/3397	20/8135	0.2984	0.4966	0.3522	MTHFD2/MTR/SHMT2/ATIC/TYMS/SHMT1/DHFR/AMT/MTFMT/ALDH1L1	10
KEGG	hsa04664	Fc epsilon RI signaling pathway	31/3397	68/8135	0.3001	0.4966	0.3522	ALOX5/FYN/RAC2/MAPK12/ALOX5AP/LYN/MAP2K1/TNF/KRAS/PIK3R3/LCP2/MAPK13/HRAS/PLCG2/RAF1/RAC1/FCER1A/MAPK8/PIK3CD/NRAS/MAP2K2/GRB2/VAV1/MAPK1/MAP2K4/IL3/MAPK11/PRKCA/LAT/PIK3CB/MAPK9	31
KEGG	hsa02010	ABC transporters	21/3397	45/8135	0.3003	0.4966	0.3522	ABCC5/TAP2/TAP1/ABCD4/DEFB1/ABCD3/ABCB6/ABCA1/ABCB10/ABCA5/ABCB5/ABCG1/ABCB4/ABCB11/ABCA7/ABCC10/ABCA6/ABCC3/ABCC4/ABCD1/ABCB7	21
KEGG	hsa04217	Necroptosis	70/3397	159/8135	0.306	0.5034	0.3569	AIFM1/STAT6/STAT3/CAPN2/NLRP3/TNFRSF10A/TNFAIP3/BIRC2/STAT1/SQSTM1/JAK2/IFNAR1/FAS/TNF/TICAM1/IFNGR2/CHMP4B/FTL/IRF9/TLR4/TNFSF10/CASP8/STAT5A/IL1B/SPATA2L/HMGB1/SPATA2/TRADD/RBCK1/GLUD1/CYLD/SLC25A5/GLUD2/MAPK8/BCL2/BAX/CHMP2A/TYK2/BIRC3/IL1A/CASP1/MLKL/VDAC2/ZBP1/CHMP1A/CYBB/VPS4B/CAMK2A/DNM1L/VDAC1/TNFRSF10B/CAMK2D/IFNGR1/EIF2AK2/FADD/TRAF2/TRAF5/IFNG/JAK1/PYGM/SMPD1/HSP90AB1/TLR3/IFNAR2/PYGL/VDAC3/XIAP/CHMP1B/CAMK2B/MAPK9	70
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	17/3397	36/8135	0.3075	0.5034	0.3569	PNP/NAMPT/QPRT/BST1/SIRT4/NMNAT3/NT5C/NMNAT1/SIRT7/NADK2/SIRT1/SIRT5/NMRK2/NMNAT2/NT5M/AOX1/NNT	17
KEGG	hsa04014	Ras signaling pathway	101/3397	232/8135	0.3115	0.5072	0.3596	IGF1/RAC2/PLA2G12A/ARF6/RALGDS/RAP1B/FLT1/VEGFB/RASGRP2/GNB1/GNB2/KITLG/MAP2K1/RASGRP3/GNG5/RRAS/SHOC2/PRKACB/NFKB1/KRAS/GAB1/PIK3R3/REL/PLD1/RELA/GNG7/HGF/PAK1/RASSF5/PLA1A/INSR/IKBKG/FLT3LG/FLT3/PDGFC/RGL1/IGF1R/RASA2/VEGFA/ETS2/HRAS/ABL1/PAK2/PLCG2/RASGRP1/RAP1A/RASAL3/SHC1/RAF1/RAC1/PDGFB/GNG2/FGF1/GNB3/ETS1/RASA3/PLA2G3/MAPK8/RAB5C/PIK3CD/PRKACA/NRAS/RAB5A/SYNGAP1/MAP2K2/GRB2/PDGFA/FOXO4/KSR2/GNB4/RASGRF1/EGFR/ABL2/CALML3/PLD2/RALBP1/MAPK1/BAD/PLA2G6/GNG11/RASAL1/GNG12/RIN1/CSF1R/RHOA/SHC3/EFNA2/MET/CHUK/SHC4/FGF23/PRKCA/RASGRP4/LAT/EXOC2/PDGFD/NTRK2/FGF6/PIK3CB/EFNA3/MAPK9	101
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	13/3397	27/8135	0.3134	0.5072	0.3596	ACAA1/ACOT7/ELOVL5/SCP2/SCD/ACOX1/TECR/HSD17B4/ELOVL7/ACOX3/ELOVL6/FADS2/HSD17B12	13
KEGG	hsa04390	Hippo signaling pathway	69/3397	157/8135	0.3143	0.5072	0.3596	MPP5/PPP2CA/WNT5A/CCND3/SMAD7/MOB1A/BIRC2/SMAD2/YWHAH/MYC/DVL2/GSK3B/CCND2/ACTB/TGFB1/CTNNA1/CSNK1D/LATS1/FZD9/BMP2/SAV1/BMP7/CCND1/FGF1/TCF7L1/CSNK1E/CTNNA3/BMP5/BMPR1A/PPP2R2D/BMP4/PPP2R2B/SERPINE1/ID2/BIRC3/NKD2/YWHAQ/TEAD2/FZD5/PARD6B/FZD1/PPP1CC/PPP1CA/PPP2R1B/FZD4/DVL1/WNT1/TCF7L2/YWHAE/TGFB3/LLGL1/LATS2/PPP1CB/FZD7/WNT2B/YWHAG/PRKCZ/WNT6/MOB1B/FZD2/WNT10A/WNT7A/WNT10B/BMPR1B/WWC1/PPP2R2C/FZD10/BMPR2/GDF5	69
KEGG	hsa03013	Nucleocytoplasmic transport	48/3397	108/8135	0.3172	0.5093	0.3612	NXF1/NUP62/NUP160/IPO13/NUP214/TNPO1/RAN/ALYREF/RNPS1/MAGOHB/NUP85/NXT1/SEH1L/KPNA4/NUP43/RBM8A/TMEM33/SNUPN/DDX19B/POM121/XPOT/SUMO1/IPO4/NUP88/THOC2/CSE1L/NUP107/THOC5/NXT2/EEF1A2/NUP93/IPO9/THOC6/SRRM1/NUP205/IPO7/PHAX/KPNA1/NUP50/SUMO4/UBE2I/TNPO3/SAP18/KPNB1/XPO4/POM121C/AAAS/UPF1	48
KEGG	hsa04725	Cholinergic synapse	50/3397	113/8135	0.327	0.5225	0.3705	FOS/FYN/GNAI3/GNB1/GNB2/MAP2K1/GNG5/JAK2/PRKACB/KRAS/PIK3R3/ATF4/GNG7/CREB5/ITPR1/GNAQ/HRAS/CREB3L2/PIK3R6/CREB1/ADCY7/GNG2/CREB3L4/GNB3/ADCY1/BCL2/ADCY3/GNAI2/PIK3CD/PRKACA/NRAS/CREB3/KCNQ1/GNB4/CAMK2A/CHRM2/CHRNA4/CAMK2D/PLCB1/MAPK1/CHRNB2/GNG11/GNG12/PIK3CG/CHAT/CACNA1F/PRKCA/GNA11/PIK3CB/CAMK2B	50
KEGG	hsa04371	Apelin signaling pathway	61/3397	139/8135	0.3337	0.5307	0.3763	SLC8A1/KLF2/MEF2A/GNAI3/SPP1/GNB1/GNB2/MAP2K1/SMAD2/GNG5/RRAS/EGR1/PRKACB/SLC9A1/KRAS/NOTCH3/GNG7/ITPR1/MAP1LC3A/GNAQ/RYR1/HRAS/ACTA2/PIK3R6/RAF1/CCND1/ADCY7/GNG2/PPARGC1A/MAP1LC3C/GNB3/ADCY1/SPHK1/PRKAG2/ADCY3/GNAI2/SERPINE1/HDAC4/PRKACA/NRAS/MAP2K2/GNB4/UCP1/MYLK/PLCB1/CALML3/SLC8A2/PRKAA1/MAPK1/GNA13/GNG11/PRKAG1/RPS6KB2/GNG12/PIK3CG/MTOR/HDAC5/SLC8A3/MEF2C/APLN/PRKAB1	61
KEGG	hsa03015	mRNA surveillance pathway	43/3397	97/8135	0.3381	0.5353	0.3796	PCF11/PPP2CA/NXF1/CSTF3/ALYREF/DAZAP1/RNPS1/MAGOHB/NXT1/PPP2R3A/RBM8A/DDX19B/SYMPK/CPSF3/CLP1/PPP2R5C/PAPOLA/RNGTT/GSPT2/FIP1L1/PPP2R2D/PPP2R2B/FUS/ETF1/PPP2R3C/CSTF1/NXT2/PPP1CC/PPP1CA/PPP2R1B/SRRM1/PPP1CB/MSI2/PPP2R5B/CPSF2/SAP18/CPSF1/CPSF7/WDR82/PABPC4L/TARDBP/PPP2R2C/UPF1	43
KEGG	hsa04720	Long-term potentiation	30/3397	67/8135	0.3505	0.5522	0.3915	RPS6KA2/RAP1B/RPS6KA3/MAP2K1/PRKACB/KRAS/ATF4/PPP3CB/ITPR1/GNAQ/HRAS/RAP1A/ARAF/RAF1/ADCY1/PRKACA/NRAS/MAP2K2/CAMK2A/GRIN2C/PPP1CC/CAMK2D/PLCB1/PPP1CA/CALML3/MAPK1/PPP1CB/PRKCA/GRIA2/CAMK2B	30
KEGG	hsa05143	African trypanosomiasis	17/3397	37/8135	0.3602	0.5644	0.4003	MYD88/FAS/TNF/GNAQ/HBB/IDO1/IL1B/IL6/APOL1/PLCB1/IL18/IDO2/APOA1/IFNG/THOP1/IL12B/PRKCA	17
KEGG	hsa04911	Insulin secretion	38/3397	86/8135	0.3616	0.5644	0.4003	KCNMB1/KCNN4/ATP1A1/PRKACB/ATF4/CREB5/GNAQ/CREB3L2/CREB1/TRPM4/ATP1B2/ADCY7/CREB3L4/ADCY1/ATP1B3/ADCY3/ATP1B1/PRKACA/CREB3/PDX1/CAMK2A/CAMK2D/PLCB1/RAB3A/ATP1B4/FXYD2/KCNMA1/KCNMB4/RIMS2/GCG/ATP1A2/CACNA1F/ADCYAP1R1/PRKCA/GNA11/ATF6B/CAMK2B/CCKAR	38
KEGG	hsa04623	Cytosolic DNA-sensing pathway	28/3397	63/8135	0.3776	0.5831	0.4135	IRF7/NFKBIA/CXCL10/NFKB1/AIM2/RELA/IKBKG/DDX58/NFKBIB/IL1B/CCL5/POLR2L/MAVS/IL6/POLR2H/CASP1/POLR1C/ZBP1/POLR2F/IL18/POLR3E/POLR2K/POLR3F/ADAR/POLR3GL/CHUK/CCL4/POLR3K	28
KEGG	hsa04340	Hedgehog signaling pathway	25/3397	56/8135	0.3784	0.5831	0.4135	DISP1/CUL1/CSNK1G2/EVC/PRKACB/GSK3B/CCND2/ARRB1/MEGF8/CSNK1D/PTCH2/CCND1/IQCE/CSNK1A1/CSNK1E/BCL2/HHAT/PRKACA/CSNK1G3/SPOPL/GPR161/CSNK1G1/SMO/BOC/PTCH1	25
KEGG	hsa04672	Intestinal immune network for IgA production	22/3397	49/8135	0.3788	0.5831	0.4135	ITGB7/CD40/IL15/CXCL12/TGFB1/TNFSF13B/ITGA4/HLA-DPB1/HLA-DPA1/HLA-DMB/ICOSLG/HLA-DOB/IL6/HLA-DRA/HLA-DMA/IL15RA/MADCAM1/ICOS/TNFRSF13B/TNFRSF13C/CD80/HLA-DOA	22
KEGG	hsa04060	Cytokine-cytokine receptor interaction	126/3397	295/8135	0.3893	0.5965	0.423	IL2RG/CCR2/CX3CR1/IL27RA/IL1R2/ACVR2B/IL17RA/TNFRSF14/TNFRSF10A/RELT/IL13RA1/CD40/PPBP/ACKR3/IL4R/CXCL9/CXCL11/IL15/IFNAR1/FAS/TNFRSF10D/TNF/TNFRSF21/CXCL10/IL1RAP/CXCL12/IL32/IL7R/IL21R/IFNGR2/CSF2RA/TGFB1/CSF2RB/IL18R1/LEP/TNFSF13B/IL3RA/CXCL13/IL20RB/EPOR/IL2RB/BMP2/TNFRSF10C/TNFRSF12A/TNFSF10/IL1B/CCL5/TNFRSF11A/IL7/CCL7/TNFRSF18/IL1RN/IL6ST/BMP7/IL1R1/CXCR1/IL6/ACVR1B/IL16/CCR5/EDA/IL15RA/CCL13/BMP5/BMPR1A/EDAR/CCL8/BMP4/CLCF1/CCR6/IL1A/IFNK/OSM/INHBA/IL12RB1/CXCR6/CCR4/EBI3/TNFRSF10B/CNTF/CCR3/IFNGR1/CXCR2/IL18/CCL20/TNFRSF13B/CCL26/TNFSF4/IL13RA2/CNTFR/TNFRSF4/IL25/IL17B/IL3/TGFB3/TSLP/IFNG/TNFSF18/CSF3R/CD4/TNFRSF25/INHA/TNFRSF13C/IFNAR2/IL12B/CSF1R/IL18RAP/CX3CL1/CXCR3/CCL19/CCL4/GHR/CCR7/TNFSF8/IL26/CCL24/BMPR1B/IL17RB/AMHR2/IL23A/IL17RC/CXCL6/THPO/BMPR2/IL37/GDF5	126
KEGG	hsa04728	Dopaminergic synapse	57/3397	132/8135	0.4014	0.6121	0.4341	KCNJ5/FOS/MAPK12/PPP2CA/GNAI3/GNB1/GNB2/GNG5/PRKACB/GSK3B/ATF4/GNG7/PPP3CB/CREB5/ITPR1/ARRB1/GNAQ/PPP2R3A/MAPK13/MAOA/CREB3L2/CREB1/GNG2/PPP2R5C/CREB3L4/GNB3/MAPK8/GNAI2/PPP2R2D/PPP2R2B/PRKACA/PPP2R3C/CREB3/GNB4/CAMK2A/PPP1CC/CAMK2D/PLCB1/PPP1CA/PPP2R1B/CLOCK/CALML3/MAOB/GNG11/ARNTL/MAPK11/KIF5B/PPP1CB/GNG12/PPP2R5B/LRTOMT/PRKCA/GRIA2/PPP2R2C/ATF6B/CAMK2B/MAPK9	57
KEGG	hsa00410	beta-Alanine metabolism	14/3397	31/8135	0.4162	0.6318	0.448	ALDH3A2/ALDH9A1/ALDH7A1/ALDH6A1/ACADS/DPYD/ALDH2/ACOX1/MLYCD/CNDP2/EHHADH/HADHA/ACOX3/ALDH3A1	14
KEGG	hsa05410	Hypertrophic cardiomyopathy	39/3397	90/8135	0.4197	0.6343	0.4498	IGF1/SLC8A1/LMNA/ITGA5/ITGB7/ITGB5/TPM3/TNF/CACNA2D3/ACTB/TGFB1/ITGA4/ITGA7/ACTC1/ITGA11/MYBPC3/EMD/DMD/IL6/TPM4/PRKAG2/TPM1/ITGA2/ITGA3/ATP2A2/SLC8A2/LAMA2/PRKAA1/ITGA8/TGFB3/CACNG6/PRKAG1/CACNB3/DAG1/SLC8A3/CACNA2D4/CACNA1F/PRKAB1/LAMA1	39
KEGG	hsa00350	Tyrosine metabolism	16/3397	36/8135	0.4337	0.6525	0.4627	IL4I1/MIF/ADH5/FAH/MAOA/GSTZ1/GOT2/ADH1B/DCT/MAOB/FAHD1/DBH/LRTOMT/AOX1/ALDH3A1/ADH7	16
KEGG	hsa00730	Thiamine metabolism	7/3397	15/8135	0.4453	0.6669	0.4729	NTPCR/AK2/NFS1/AK8/TPK1/ALPP/THTPA	7
KEGG	hsa00983	Drug metabolism - other enzymes	34/3397	80/8135	0.489	0.7292	0.5171	TYMP/UPP1/TPMT/MGST2/GSTP1/GMPS/IMPDH1/DPYD/GSTO1/CMPK1/TK1/CES2/GSTA1/GSTM3/NME3/GUSB/NME4/MGST1/GSTM5/NME1/RRM2/GSTM4/UCK1/TK2/RRM2B/MGST3/NAT2/CDA/UCKL1/UPP2/NAT1/DUT/CYP2A6/MPO	34
KEGG	hsa00561	Glycerolipid metabolism	26/3397	61/8135	0.4943	0.7328	0.5196	ALDH3A2/AKR1B1/ALDH9A1/DGKA/GPAM/ALDH7A1/GK/MGLL/MBOAT1/PNPLA3/DGKD/AKR1A1/AGPAT3/ALDH2/DGAT2/GLA/AGPAT4/MBOAT2/AKR1B10/AGK/AGPAT5/DGKG/PNLIPRP1/AGPAT1/GLYCTK/AGPAT2	26
KEGG	hsa00562	Inositol phosphate metabolism	31/3397	73/8135	0.4958	0.7328	0.5196	ALDH6A1/INPP1/SACM1L/TPI1/SYNJ1/FIG4/PLCG2/SYNJ2/CDIPT/OCRL/MTMR4/INPP5K/IMPA2/MTMR6/PIK3CD/PI4K2A/MTMR2/INPP5F/PLCD1/PLCB1/IPPK/PLCD4/MTMR3/MINPP1/PIK3CG/PIP5K1B/INPPL1/INPP5A/PIK3CB/IMPA1/PI4KB	31
KEGG	hsa04914	Progesterone-mediated oocyte maturation	43/3397	102/8135	0.5053	0.7403	0.5249	IGF1/RPS6KA2/MAPK12/MAD2L2/GNAI3/RPS6KA3/MAP2K1/PRKACB/KRAS/PIK3R3/MAPK13/IGF1R/ARAF/RAF1/ADCY7/CDC23/ADCY1/ANAPC5/MAPK8/ADCY3/GNAI2/ANAPC7/PIK3CD/CPEB1/PRKACA/CDC25A/CPEB3/MOS/CDC26/CCNA1/MAPK1/ANAPC4/CDC27/MAPK11/HSP90AB1/CCNA2/AURKA/ANAPC11/ANAPC13/CCNB3/CPEB2/PIK3CB/MAPK9	43
KEGG	hsa04972	Pancreatic secretion	43/3397	102/8135	0.5053	0.7403	0.5249	ATP2B4/PLA2G12A/BST1/ATP1A1/RAP1B/RAB11A/SLC9A1/ITPR1/GNAQ/SCTR/CTRL/RAP1A/RAB8A/RAC1/ATP1B2/ADCY7/PRSS3/ADCY1/ATP1B3/SLC12A2/PLA2G3/CPA3/ADCY3/ATP1B1/CELA3A/CTRB2/KCNQ1/PLCB1/ATP2A2/CELA3B/ATP1B4/FXYD2/CLCA1/PNLIPRP1/KCNMA1/RHOA/RAB3D/ATP1A2/CPB1/PRKCA/PRSS2/CPA2/CCKAR	43
KEGG	hsa03420	Nucleotide excision repair	20/3397	47/8135	0.5117	0.7421	0.5262	RAD23B/ERCC6/ERCC4/RPA1/DDB1/CCNH/POLD4/POLD2/RFC3/GTF2H4/PCNA/ERCC1/CETN2/DDB2/ERCC2/POLD1/CUL4B/RBX1/POLE4/ERCC8	20
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	60/3397	143/8135	0.5128	0.7421	0.5262	KLF4/IGF1/MAPK12/SKIL/ACVR2B/WNT5A/STAT3/SMAD5/MAP2K1/SMAD2/MYC/JAK2/DVL2/KRAS/GSK3B/PIK3R3/PCGF2/MAPK13/PCGF1/FZD9/PCGF3/IGF1R/HRAS/RAF1/SMARCAD1/IL6ST/ACVR1B/BMPR1A/BMP4/PIK3CD/ID2/NRAS/SETDB1/INHBA/MAP2K2/GRB2/FZD5/FZD1/HOXB1/FZD4/DVL1/WNT1/POU5F1B/MAPK1/JAK1/MAPK11/FZD7/WNT2B/MEIS1/ESRRB/WNT6/FZD2/WNT10A/WNT7A/WNT10B/BMPR1B/FZD10/HOXD1/PIK3CB/BMPR2	60
KEGG	hsa04022	cGMP-PKG signaling pathway	70/3397	167/8135	0.5132	0.7421	0.5262	SLC8A1/VASP/KCNMB1/ATP2B4/MEF2A/ATP1A1/GNAI3/MAP2K1/RGS2/ATF4/PPP3CB/CREB5/NFATC3/ITPR1/GNAQ/SRF/INSR/ADRB1/CREB3L2/PIK3R6/CREB1/RAF1/ATP1B2/ADCY7/IRS2/SLC25A5/MRVI1/CREB3L4/ADCY1/ATP1B3/ADCY3/GNAI2/NFATC1/NFATC2/ATP1B1/KCNJ8/ADRB2/CREB3/MAP2K2/VDAC2/VDAC1/MYLK/PPP1CC/PLCB1/PPP1CA/ATP2A2/CALML3/SLC8A2/MAPK1/GNA13/BAD/ATP1B4/ADRA1D/FXYD2/PPP1CB/OPRD1/PIK3CG/VDAC3/KCNMA1/RHOA/KCNMB4/ADORA3/ATP1A2/SLC8A3/ROCK2/CACNA1F/GNA11/ATF6B/MEF2C/GTF2I	70
KEGG	hsa04971	Gastric acid secretion	32/3397	76/8135	0.5194	0.7478	0.5303	KCNJ15/EZR/ATP1A1/GNAI3/PRKACB/SLC9A1/ACTB/ITPR1/GNAQ/ATP4A/KCNJ1/ATP1B2/ADCY7/ADCY1/ATP1B3/ADCY3/GNAI2/ATP1B1/PRKACA/KCNQ1/KCNK2/CAMK2A/MYLK/CAMK2D/PLCB1/CALML3/ATP1B4/CCKBR/KCNE2/ATP1A2/PRKCA/CAMK2B	32
KEGG	hsa05231	Choline metabolism in cancer	41/3397	98/8135	0.5325	0.7633	0.5413	FOS/RAC2/SLC22A4/RALGDS/TSC1/CHPT1/DGKA/MAP2K1/GPCPD1/SLC22A5/KRAS/PIK3R3/PLD1/DGKD/HIF1A/PDGFC/HRAS/RAF1/RAC1/PDGFB/MAPK8/PIK3CD/NRAS/MAP2K2/GRB2/PDGFA/CHKA/EGFR/PLD2/MAPK1/DGKG/RPS6KB2/SLC44A2/MTOR/PIP5K1B/CHKB/WAS/PRKCA/PDGFD/PIK3CB/MAPK9	41
KEGG	hsa04979	Cholesterol metabolism	21/3397	50/8135	0.5402	0.7677	0.5444	CYP27A1/NPC2/LIPA/APOC1/SCARB1/SOAT1/CETP/APOE/CD36/LRPAP1/ABCA1/LDLR/LRP1/VAPB/LCAT/VDAC2/ABCB11/VDAC1/APOA1/NCEH1/VDAC3	21
KEGG	hsa05144	Malaria	21/3397	50/8135	0.5402	0.7677	0.5444	MYD88/TLR2/GYPC/CD40/TNF/THBS3/TGFB1/HGF/CD36/ITGAL/HBB/TLR4/IL1B/LRP1/IL6/CR1/KLRB1/IL18/TGFB3/IFNG/MET	21
KEGG	hsa00770	Pantothenate and CoA biosynthesis	9/3397	21/8135	0.5424	0.7677	0.5444	ALDH3A2/PANK2/PANK3/PANK1/DPYD/ALDH2/VNN1/AASDHPPT/BCAT2	9
KEGG	hsa05414	Dilated cardiomyopathy	40/3397	96/8135	0.5464	0.7701	0.5461	IGF1/SLC8A1/LMNA/ITGA5/ITGB7/ITGB5/TPM3/TNF/PRKACB/CACNA2D3/ACTB/TGFB1/ITGA4/ITGA7/ADRB1/ACTC1/ITGA11/MYBPC3/EMD/DMD/ADCY7/ADCY1/TPM4/ADCY3/TPM1/PRKACA/ITGA2/ITGA3/ATP2A2/SLC8A2/LAMA2/ITGA8/TGFB3/CACNG6/CACNB3/DAG1/SLC8A3/CACNA2D4/CACNA1F/LAMA1	40
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	32/3397	77/8135	0.5578	0.7828	0.5551	SLC8A1/LMNA/ITGA5/ITGB7/ITGB5/CACNA2D3/ACTB/CTNNA1/ITGA4/ITGA7/ITGA11/EMD/DMD/TCF7L1/CTNNA3/ITGA2/ITGA3/DSC2/ATP2A2/SLC8A2/LAMA2/TCF7L2/ITGA8/CACNG6/PKP2/CACNB3/DAG1/SLC8A3/CACNA2D4/GJA1/CACNA1F/LAMA1	32
KEGG	hsa05310	Asthma	13/3397	31/8135	0.5604	0.7832	0.5554	CD40/TNF/RNASE3/HLA-DPB1/HLA-DPA1/HLA-DMB/PRG2/HLA-DOB/HLA-DRA/HLA-DMA/FCER1A/IL3/HLA-DOA	13
KEGG	hsa00512	Mucin type O-glycan biosynthesis	15/3397	36/8135	0.5679	0.7903	0.5604	GALNT14/ST6GALNAC4/ST3GAL2/GALNT7/GALNT6/GCNT1/GALNT12/GALNT10/B4GALT5/GALNT9/ST3GAL1/ST6GALNAC3/C1GALT1/GALNT1/GALNT15	15
KEGG	hsa03440	Homologous recombination	17/3397	41/8135	0.5747	0.7933	0.5626	BARD1/SYCP3/RPA1/SSBP1/UIMC1/POLD4/RAD51B/PALB2/POLD2/ATM/RAD52/RAD54B/BRCA1/POLD1/TOPBP1/BRCC3/TOP3B	17
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	8/3397	19/8135	0.5748	0.7933	0.5626	NAGS/IDH1/ACO1/IDH2/GOT2/IDH3A/BCAT2/IDH3G	8
KEGG	hsa04114	Oocyte meiosis	54/3397	131/8135	0.5832	0.8016	0.5684	IGF1/RPS6KA2/MAPK12/MAD2L2/PPP2CA/CUL1/RPS6KA3/MAP2K1/YWHAH/PRKACB/REC8/PPP3CB/ITPR1/MAPK13/IGF1R/SLK/ADCY7/CDC23/PPP2R5C/ESPL1/ADCY1/ANAPC5/CCNE1/ADCY3/ANAPC7/CPEB1/PRKACA/YWHAQ/CPEB3/CAMK2A/MOS/PPP1CC/CDC26/CAMK2D/PPP1CA/STAG3/PPP2R1B/CALML3/MAPK1/YWHAE/SMC3/ANAPC4/CDC27/MAPK11/CDC20/PPP1CB/PPP2R5B/YWHAG/AURKA/ANAPC11/RBX1/ANAPC13/CPEB2/CAMK2B	54
KEGG	hsa04611	Platelet activation	51/3397	124/8135	0.591	0.809	0.5736	FYN/VASP/APBB1IP/MAPK12/MYL12A/LYN/RAP1B/RASGRP2/GNAI3/PRKACB/PIK3R3/LCP2/ACTB/TLN1/ITPR1/GNAQ/MAPK13/PLCG2/RASGRP1/RAP1A/PIK3R6/P2RY12/ADCY7/ADCY1/P2RX1/ADCY3/GNAI2/PIK3CD/TLN2/PRKACA/ITGA2/VWF/F2R/MYLK/PPP1CC/PLCB1/PPP1CA/MYL12B/ORAI1/MAPK1/GNA13/MAPK11/PPP1CB/FCGR2A/PIK3CG/PRKCZ/RHOA/ROCK2/P2RY1/PTGS1/PIK3CB	51
KEGG	hsa05030	Cocaine addiction	20/3397	49/8135	0.607	0.8275	0.5868	FOSB/GNAI3/PRKACB/NFKB1/ATF4/RELA/CREB5/MAOA/CDK5/CREB3L2/CREB1/GPSM1/CREB3L4/GNAI2/PRKACA/CREB3/GRIN2C/MAOB/GRIA2/ATF6B	20
KEGG	hsa00120	Primary bile acid biosynthesis	7/3397	17/8135	0.6105	0.8281	0.5872	CYP27A1/SCP2/HSD17B4/ACOX2/CH25H/CYP46A1/ACOT8	7
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	40/3397	98/8135	0.6133	0.8281	0.5872	IGF1/HTR2B/PTGER4/MAPK12/PTGER2/PRKACB/IL1RAP/PIK3R3/ITPR1/GNAQ/PRKCD/MAPK13/CYP2J2/IL1B/PLCG2/IL1R1/ADCY7/ADCY1/MAPK8/ADCY3/PIK3CD/PRKACA/CAMK2A/PPP1CC/CAMK2D/PLCB1/PPP1CA/CALML3/PLA2G6/MAPK11/PPP1CB/BDKRB1/PRKCQ/TRPV4/PRKCA/TRPV3/TRPV2/PIK3CB/CAMK2B/MAPK9	40
KEGG	hsa00062	Fatty acid elongation	11/3397	27/8135	0.6149	0.8281	0.5872	HADHB/HADH/ACOT7/ELOVL5/TECR/ELOVL7/THEM4/HADHA/ACAA2/ELOVL6/HSD17B12	11
KEGG	hsa04015	Rap1 signaling pathway	86/3397	210/8135	0.6207	0.8325	0.5904	IGF1/ITGAM/FPR1/VASP/RAC2/SIPA1L1/APBB1IP/MAPK12/RALGDS/RAP1B/FLT1/VEGFB/RASGRP2/GNAI3/ARAP3/KITLG/MAP2K1/RASGRP3/RRAS/RAPGEF6/KRAS/PIK3R3/LCP2/EVL/ACTB/TLN1/PFN1/HGF/LPAR5/GNAQ/RAPGEF2/LPAR2/ITGAL/RASSF5/INSR/MAPK13/PDGFC/IGF1R/VEGFA/HRAS/RAP1A/CRK/RAF1/RAC1/ADCY7/PDGFB/FGF1/KRIT1/ADCY1/ADORA2B/PRKD2/ADCY3/GNAI2/RGS14/PIK3CD/TLN2/NRAS/LPAR3/SIPA1L3/MAP2K2/PDGFA/PARD6B/LPAR1/F2R/PLCB1/VAV1/EGFR/CALML3/MAPK1/SKAP1/MAPK11/ENAH/PRKCZ/CSF1R/RHOA/EFNA2/MET/SIPA1L2/FGF23/PRKCA/P2RY1/LAT/PDGFD/FGF6/PIK3CB/EFNA3	86
KEGG	hsa00230	Purine metabolism	52/3397	128/8135	0.636	0.8497	0.6025	LACC1/PNP/PAPSS1/FHIT/NTPCR/AK3/ENTPD1/AK2/HDDC3/GMPS/DGUOK/NT5C/ADK/GUK1/PAICS/IMPDH1/PDE4B/AK8/PDE6G/NUDT9/ADCY7/PDE6D/ADCY1/NME3/PGM2/NME4/GMPR2/ATIC/ADCY3/PDE7A/PAPSS2/NME1/NUDT5/PRPS1/PPAT/ALLC/RRM2/AMPD2/ADPRM/ADA/DCK/RRM2B/AK6/GUCY2D/PRPS1L1/PRPS2/PDE8A/ENPP4/NT5M/AMPD3/NUDT16/PDE8B	52
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	12/3397	30/8135	0.6448	0.858	0.6084	MDH1/CAT/MCEE/ACO1/SHMT2/PCCB/HYI/SHMT1/AMT/GRHPR/GLYCTK/HAO1	12
KEGG	hsa03022	Basal transcription factors	18/3397	45/8135	0.6494	0.8607	0.6103	GTF2E1/TAF5L/CCNH/TAF11/TAF12/GTF2F2/TAF5/GTF2H4/GTF2F1/TAF6L/TBPL1/GTF2A1/ERCC2/TAF9B/TAF4/TBP/TAF7/GTF2I	18
KEGG	hsa04927	Cortisol synthesis and secretion	26/3397	65/8135	0.6586	0.8694	0.6165	SCARB1/PRKACB/ATF4/CREB5/ITPR1/GNAQ/CREB3L2/LDLR/CREB1/ADCY7/CREB3L4/ADCY1/ADCY3/PRKACA/CREB3/KCNK2/PLCB1/ORAI1/NCEH1/KCNA4/PDE8A/CACNA1H/CACNA1F/GNA11/PDE8B/ATF6B	26
KEGG	hsa04714	Thermogenesis	94/3397	232/8135	0.6749	0.8821	0.6255	RPS6KA2/MAPK12/TSC1/UQCRC2/RPS6KA3/SLC25A20/COX11/ACSL5/MGLL/UQCR11/PRKACB/NDUFA8/ZNF516/KRAS/COA5/ACTB/CPT2/NDUFC1/CREB5/NDUFB11/COX19/MAPK13/NDUFAF4/NDUFAF7/NDUFS3/ACSL4/COX20/NDUFA3/HRAS/CREB3L2/NDUFA11/CREB1/UQCR10/COX7C/ARID1B/ADCY7/MLST8/PPARGC1A/CREB3L4/ADCY1/COX7A2L/NDUFA4/ACSL6/PRKAG2/COX4I2/NDUFA1/NDUFAF3/ADCY3/COA7/COX16/PRKACA/NRAS/CREB3/COA6/COX15/GRB2/CPT1A/AKT1S1/NDUFA10/NDUFB1/NDUFB5/UQCRQ/MAP3K5/UCP1/NDUFS1/COA3/COA4/KLB/NDUFB8/PRKAA1/COX14/NDUFB6/SMARCC2/MAPK11/PRKAG1/RPS6KB2/NDUFB3/SDHA/NDUFS7/NDUFAF2/NDUFV2/ND4/SDHD/MTOR/UQCRB/NDUFB2/SMARCC1/COX6C/GCG/ACTL6A/NDUFS2/NDUFA7/PRKAB1/COX7B	94
KEGG	hsa03430	Mismatch repair	9/3397	23/8135	0.6761	0.8821	0.6255	RPA1/SSBP1/POLD4/POLD2/RFC3/MLH1/PCNA/EXO1/POLD1	9
KEGG	hsa04614	Renin-angiotensin system	9/3397	23/8135	0.6761	0.8821	0.6255	CTSA/PREP/ATP6AP2/NLN/CPA3/CMA1/CTSG/REN/THOP1	9
KEGG	hsa04930	Type II diabetes mellitus	18/3397	46/8135	0.6934	0.9011	0.639	HK3/SOCS3/TNF/PIK3R3/PKM/PRKCD/INSR/IRS2/MAPK8/PIK3CD/PDX1/MAPK1/SOCS1/PRKCZ/MTOR/SOCS2/PIK3CB/MAPK9	18
KEGG	hsa04929	GnRH secretion	25/3397	64/8135	0.7126	0.9139	0.6481	KCNJ5/KCNN4/GABBR1/SPP1/MAP2K1/KRAS/PIK3R3/ITPR1/ARRB1/GNAQ/HRAS/RAF1/PIK3CD/NRAS/MAP2K2/PLCB1/KISS1R/MAPK1/HCN1/CACNA1H/CACNA1F/PRKCA/GNA11/KISS1/PIK3CB	25
KEGG	hsa03460	Fanconi anemia pathway	21/3397	54/8135	0.7128	0.9139	0.6481	ERCC4/RPA1/RMI2/PALB2/POLI/POLH/MLH1/ERCC1/RMI1/USP1/HES1/FANCL/BRCA1/ATR/FANCF/FANCG/FANCM/TELO2/FANCD2/FANCA/TOP3B	21
KEGG	hsa05031	Amphetamine addiction	27/3397	69/8135	0.7129	0.9139	0.6481	FOS/FOSB/PRKACB/ATF4/PPP3CB/CREB5/MAOA/CREB3L2/CREB1/SIRT1/ARC/CREB3L4/HDAC2/PRKACA/CREB3/CAMK2A/GRIN2C/PPP1CC/CAMK2D/PPP1CA/CALML3/MAOB/PPP1CB/PRKCA/GRIA2/ATF6B/CAMK2B	27
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	85/3397	212/8135	0.7142	0.9139	0.6481	KLF4/EPHX1/FOS/VDR/RPS6KA2/DLL1/PAQR7/NOTCH2/STAT3/CCND3/GNAI3/BCL6/RPS6KA3/MAP2K1/MYC/MGST2/JAK2/PRKACB/NFKB1/KRAS/PIK3R3/ATF4/RELA/CREB5/CYP1B1/ARRB1/KPNA4/ADRB1/VEGFA/HRAS/STAT5A/GSTO1/CREB3L2/AHR/GSTA1/CREB1/RAF1/CCND1/ADCY7/GSTM3/CREB3L4/ADCY1/PTGES3/MGST1/RXRA/CYP1A2/BCL2/ADCY3/GNAI2/GSTM5/PIK3CD/PRKACA/NRAS/ADRB2/KLF5/CDC25A/CREB3/MAP2K2/GRB2/PAQR5/GSTM4/ARNT/CHRNA4/EGFR/PPARA/HSP90B1/WNT1/MGST3/MAPK1/CHRNB2/KPNA1/BAD/RPS6KB2/HSP90AB1/RB1/MTOR/PAQR8/KPNB1/XIAP/CACNA1F/PRKCA/ATF6B/FGF6/PIK3CB/AIP	85
KEGG	hsa03020	RNA polymerase	13/3397	34/8135	0.7205	0.9165	0.6499	POLR2L/POLR2H/POLR1C/POLR2F/POLR2D/POLR3E/POLR2K/POLR2J2/CD3EAP/POLR3F/POLR3GL/POLR2I/POLR3K	13
KEGG	hsa00360	Phenylalanine metabolism	6/3397	16/8135	0.7216	0.9165	0.6499	IL4I1/MIF/MAOA/GOT2/MAOB/ALDH3A1	6
KEGG	hsa04260	Cardiac muscle contraction	34/3397	87/8135	0.7305	0.924	0.6552	SLC8A1/ATP1A1/UQCRC2/TPM3/UQCR11/SLC9A1/CACNA2D3/ACTC1/UQCR10/COX7C/ATP1B2/SLC9A7/COX7A2L/ATP1B3/TPM4/COX4I2/TPM1/ATP1B1/UQCRQ/ATP2A2/SLC8A2/ATP1B4/CASQ2/CACNG6/HRC/FXYD2/CACNB3/UQCRB/COX6C/ATP1A2/SLC8A3/CACNA2D4/CACNA1F/COX7B	34
KEGG	hsa04977	Vitamin digestion and absorption	9/3397	24/8135	0.7331	0.924	0.6552	SLC19A2/SCARB1/BTD/PLB1/MMACHC/SLC46A1/SLC5A6/LMBRD1/APOA1	9
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	14/3397	37/8135	0.7407	0.9285	0.6584	ASRGL1/IL4I1/ALDH4A1/GLUD1/ALDH5A1/GLUD2/ASNS/PPAT/GLS/GOT2/AGXT2/GFPT1/CAD/GFPT2	14
KEGG	hsa04610	Complement and coagulation cascades	33/3397	85/8135	0.7448	0.9285	0.6584	SERPINA1/ITGAM/SERPINB2/F5/CD55/PROS1/PROCR/TFPI/A2M/CD59/CFD/THBD/CLU/SERPING1/PLAUR/CR1/CFHR4/VSIG4/C3AR1/SERPINE1/CR2/C1R/VWF/F2R/CFB/C1QC/BDKRB1/F3/MASP2/CFHR5/SERPINF2/F9/C7	33
KEGG	hsa04730	Long-term depression	23/3397	60/8135	0.7475	0.9285	0.6584	IGF1/LYN/PPP2CA/GNAI3/MAP2K1/KRAS/ITPR1/GNAQ/RYR1/IGF1R/HRAS/ARAF/RAF1/GNAI2/NRAS/MAP2K2/PLCB1/PPP2R1B/MAPK1/GNA13/PRKCA/GRIA2/GNA11	23
KEGG	hsa04726	Serotonergic synapse	45/3397	115/8135	0.7478	0.9285	0.6584	KCNJ5/HTR2B/ALOX5/DUSP1/GNAI3/PTGS2/GNB1/GNB2/MAP2K1/GNG5/PRKACB/KRAS/GNG7/HTR1F/ITPR1/GNAQ/CYP2J2/MAOA/CASP3/HRAS/ARAF/RAF1/GNG2/GNB3/ALOX15B/CYP2D6/HTR4/GNAI2/PRKACA/NRAS/GNB4/PLCB1/TPH2/MAOB/MAPK1/GNG11/HTR5A/GNG12/HTR3B/APP/CYP2C8/CACNA1F/PRKCA/HTR3A/PTGS1	45
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	10/3397	27/8135	0.7539	0.9317	0.6606	FUT4/FUT7/B3GNT2/B3GNT5/FUT6/B3GNT4/GCNT2/B3GALT5/B4GALT1/ST8SIA1	10
KEGG	hsa04925	Aldosterone synthesis and secretion	38/3397	98/8135	0.7587	0.9317	0.6606	KCNJ5/ATP2B4/NR4A2/ATP1A1/CAMK1D/SCARB1/PRKACB/ATF4/CREB5/ITPR1/GNAQ/CREB3L2/LDLR/CREB1/ATP1B2/ADCY7/CREB3L4/ADCY1/ATP1B3/DAGLB/PRKD2/ADCY3/ATP1B1/PRKACA/CREB3/CAMK2A/CAMK2D/PLCB1/ORAI1/CALML3/ATP1B4/ATP1A2/CACNA1H/CACNA1F/PRKCA/GNA11/ATF6B/CAMK2B	38
KEGG	hsa04974	Protein digestion and absorption	40/3397	103/8135	0.7589	0.9317	0.6606	SLC8A1/KCNN4/COL23A1/SLC36A1/ATP1A1/DPP4/KCNE3/SLC7A7/COL8A2/COL4A2/SLC16A10/CTRL/ATP1B2/PRSS3/ATP1B3/CPA3/SLC7A8/COL7A1/ATP1B1/CELA3A/CTRB2/KCNQ1/SLC36A4/COL20A1/COL2A1/SLC8A2/CELA3B/COL4A3/COL15A1/ATP1B4/FXYD2/MEP1A/COL6A3/COL18A1/COL11A2/ATP1A2/SLC8A3/CPB1/PRSS2/CPA2	40
KEGG	hsa04915	Estrogen signaling pathway	54/3397	138/8135	0.763	0.9317	0.6606	KCNJ5/FOS/GABBR1/HSPA6/CTSD/GNAI3/MAP2K1/PRKACB/KRAS/PIK3R3/ATF4/CREB5/ITPR1/GNAQ/NCOA3/PRKCD/HRAS/FKBP5/CREB3L2/EBAG9/SHC1/CREB1/RAF1/ADCY7/KRT36/CREB3L4/ADCY1/MMP9/BCL2/ADCY3/GNAI2/PIK3CD/PRKACA/NRAS/KRT10/CREB3/KRT23/MAP2K2/GRB2/HSPA1L/PLCB1/EGFR/HSP90B1/CALML3/MAPK1/KRT27/HBEGF/HSP90AB1/MMP2/KRT14/SHC3/SHC4/ATF6B/PIK3CB	54
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/3397	14/8135	0.7643	0.9317	0.6606	B3GNT2/CHST2/ST3GAL2/ST3GAL1/B4GALT1	5
KEGG	hsa04520	Adherens junction	27/3397	71/8135	0.7757	0.9421	0.6681	FYN/RAC2/PTPN6/ACTN4/VCL/CSNK2A2/ACTB/CTNNA1/INSR/ACTN1/BAIAP2/IGF1R/NLK/CSNK2B/RAC1/TCF7L1/CTNNA3/FER/EGFR/MAPK1/TCF7L2/SNAI1/RHOA/MET/WAS/PTPRM/PTPRJ	27
KEGG	hsa00190	Oxidative phosphorylation	52/3397	134/8135	0.7838	0.943	0.6687	ATP6V0D2/ATP6AP1/UQCRC2/PPA1/ATP6V1C1/COX11/UQCR11/NDUFA8/ATP6V0C/NDUFC1/NDUFB11/NDUFS3/TCIRG1/NDUFA3/ATP6V1A/ATP4A/PPA2/NDUFA11/ATP6V1G3/UQCR10/COX7C/ATP6V1B2/COX7A2L/ATP6V1D/NDUFA4/COX4I2/NDUFA1/ATP6V0E2/COX15/NDUFA10/NDUFB1/NDUFB5/UQCRQ/ATP6V1G2/NDUFS1/NDUFB8/NDUFB6/NDUFB3/SDHA/NDUFS7/NDUFV2/ND4/SDHD/UQCRB/ATP6V1B1/NDUFB2/LHPP/COX6C/ATP12A/NDUFS2/NDUFA7/COX7B	52
KEGG	hsa04350	TGF-beta signaling pathway	36/3397	94/8135	0.7843	0.943	0.6687	ACVR2B/PPP2CA/CUL1/SMAD5/SMAD7/SMAD2/MYC/TNF/TGFB1/BMP2/CDKN2B/BMP7/ACVR1B/RGMB/BMP5/BMPR1A/BMP4/ID2/INHBA/TGIF1/TGIF2/E2F4/PPP2R1B/HAMP/MAPK1/TGFB3/IFNG/RPS6KB2/THSD4/RHOA/RBX1/GREM1/BMPR1B/AMHR2/BMPR2/GDF5	36
KEGG	hsa04921	Oxytocin signaling pathway	60/3397	154/8135	0.7856	0.943	0.6687	KCNJ5/FOS/CDKN1A/GNAI3/PTGS2/CAMK1D/MAP2K1/RGS2/PRKACB/KRAS/CACNA2D3/MYL6B/ACTB/PPP3CB/NFATC3/ITPR1/GNAQ/MAPK7/RYR1/HRAS/PIK3R6/RAF1/CCND1/TRPM2/ADCY7/MYL6/ADCY1/PRKAG2/ADCY3/GNAI2/NFATC1/NFATC2/PRKACA/NRAS/RCAN1/MAP2K2/CAMK2A/MYLK/PPP1CC/CAMK2D/PLCB1/PPP1CA/EGFR/CALML3/PRKAA1/MAPK1/CACNG6/PRKAG1/PPP1CB/MAP2K5/PIK3CG/CACNB3/RHOA/CACNA2D4/ROCK2/CACNA1F/PRKCA/MEF2C/CAMK2B/PRKAB1	60
KEGG	hsa04024	cAMP signaling pathway	87/3397	221/8135	0.7877	0.943	0.6687	FOS/RAC2/ATP2B4/GABBR1/ATP1A1/RAP1B/PTGER2/GNAI3/ARAP3/MAP2K1/RRAS/HCAR3/PRKACB/NFKBIA/SLC9A1/NFKB1/PIK3R3/PLD1/RELA/HTR1F/CREB5/FFAR2/PAK1/ADRB1/PDE4B/CREB3L2/ACOX1/RAP1A/CREB1/RAF1/RAC1/ATP1B2/ADCY7/CREB3L4/ADCY1/ATP1B3/HCN4/MAPK8/FXYD1/ADCY3/HTR4/GNAI2/NFATC1/PIK3CD/ATP1B1/PRKACA/ADRB2/CREB3/MAP2K2/CAMK2A/CHRM2/F2R/GRIN2C/PPP1CC/CAMK2D/PPP1CA/VAV1/ORAI1/PPARA/ATP2A2/CALML3/PLD2/GIPR/GPHB5/MAPK1/ACOX3/BAD/GPHA2/ATP1B4/VIP/FXYD2/PPP1CB/SUCNR1/FSHR/ABCC4/RHOA/GCG/ATP1A2/ROCK2/CACNA1F/ADCYAP1R1/GRIA2/PTCH1/GHRL/PIK3CB/CAMK2B/MAPK9	87
KEGG	hsa04070	Phosphatidylinositol signaling system	37/3397	97/8135	0.796	0.9488	0.6728	CDS1/DGKA/CDS2/IMPAD1/INPP1/PIK3R3/SACM1L/ITPR1/DGKD/IP6K1/SYNJ1/PLCG2/PPIP5K2/SYNJ2/CDIPT/OCRL/MTMR4/IMPA2/MTMR6/PIK3CD/PI4K2A/MTMR2/INPP5F/PLCD1/PLCB1/IPPK/CALML3/PLCD4/MTMR3/DGKG/PIP5K1B/INPPL1/PRKCA/INPP5A/PIK3CB/IMPA1/PI4KB	37
KEGG	hsa00100	Steroid biosynthesis	7/3397	20/8135	0.7983	0.9488	0.6728	LIPA/SQLE/SOAT1/TM7SF2/MSMO1/SC5D/CYP27B1	7
KEGG	hsa04723	Retrograde endocannabinoid signaling	57/3397	148/8135	0.8135	0.9635	0.6832	KCNJ5/MAPK12/GNAI3/PTGS2/GNB1/GNB2/ABHD6/GNG5/MGLL/PRKACB/NDUFA8/GNG7/NDUFC1/ITPR1/GNAQ/NDUFB11/MAPK13/NAPEPLD/NDUFS3/NDUFA3/NDUFA11/ADCY7/GNG2/GNB3/ADCY1/NDUFA4/DAGLB/NDUFA1/MAPK8/ADCY3/GNAI2/PRKACA/NDUFA10/NDUFB1/NDUFB5/GNB4/NDUFS1/PLCB1/NDUFB8/MAPK1/NDUFB6/GNG11/MAPK11/GNG12/NDUFB3/NDUFS7/NDUFV2/ND4/GABRA4/NDUFB2/CACNA1F/NDUFS2/PRKCA/GRIA2/GABRP/NDUFA7/MAPK9	57
KEGG	hsa00061	Fatty acid biosynthesis	6/3397	18/8135	0.8323	0.9823	0.6965	CBR4/ACSL5/OXSM/ACSL4/ACACB/ACSL6	6
KEGG	hsa04392	Hippo signaling pathway - multiple species	10/3397	29/8135	0.8374	0.9849	0.6984	MOB1A/DCHS1/PAK1/LATS1/SAV1/CSNK1E/TEAD2/LATS2/MOB1B/WWC1	10
KEGG	hsa05320	Autoimmune thyroid disease	19/3397	53/8135	0.845	0.9903	0.7022	CD40/FAS/HLA-F/HLA-DPB1/HLA-DPA1/HLA-E/HLA-B/HLA-DMB/HLA-DOB/HLA-G/HLA-DRA/CTLA4/HLA-DMA/HLA-C/GZMB/PRF1/HLA-A/CD80/HLA-DOA	19
KEGG	hsa00565	Ether lipid metabolism	17/3397	49/8135	0.8758	1	0.7091	LPCAT2/PLD3/PLA2G12A/ENPP2/CHPT1/PAFAH2/PLA2G7/PLD1/PAFAH1B1/AGPS/PLB1/PLA2G3/TMEM86B/PLD4/PLD2/PLA2G6/LPCAT1	17
KEGG	hsa04721	Synaptic vesicle cycle	28/3397	78/8135	0.8796	1	0.7091	ATP6V0D2/DNM3/ATP6V1C1/ATP6V0C/STXBP1/UNC13B/TCIRG1/ATP6V1A/CLTB/ATP6V1G3/ATP6V1B2/CLTCL1/ATP6V1D/DNM1/AP2A2/SLC6A5/NAPA/DNM2/ATP6V0E2/AP2S1/ATP6V1G2/AP2A1/RAB3A/SYT1/AP2M1/SLC6A13/ATP6V1B1/SLC6A12	28
KEGG	hsa00592	alpha-Linolenic acid metabolism	8/3397	25/8135	0.885	1	0.7091	PLA2G12A/ACAA1/ACOX1/PLB1/PLA2G3/ACOX3/PLA2G6/FADS2	8
KEGG	hsa00500	Starch and sucrose metabolism	12/3397	36/8135	0.8853	1	0.7091	HK3/MGAM/AGL/GYS1/GYG2/GPI/PGM2/GAA/PYGM/PYGL/TREH/G6PC	12
KEGG	hsa00514	Other types of O-glycan biosynthesis	16/3397	47/8135	0.8905	1	0.7091	LFNG/GALNT14/POGLUT1/GALNT7/GALNT6/GALNT12/GALNT10/POMT1/GALNT9/XXYLT1/POMT2/OGT/C1GALT1/B4GALT1/GALNT1/GALNT15	16
KEGG	hsa04973	Carbohydrate digestion and absorption	16/3397	47/8135	0.8905	1	0.7091	HK3/ATP1A1/MGAM/SLC37A4/PIK3R3/ATP1B2/ATP1B3/PIK3CD/ATP1B1/LCT/PLCB1/ATP1B4/FXYD2/ATP1A2/G6PC/PIK3CB	16
KEGG	hsa04713	Circadian entrainment	35/3397	97/8135	0.8939	1	0.7091	KCNJ5/FOS/GNAI3/GNB1/GNB2/PER2/GNG5/PRKACB/GNG7/ITPR1/GNAQ/RYR1/CREB1/ADCY7/GNG2/GNB3/ADCY1/ADCY3/GNAI2/PRKACA/GNB4/CAMK2A/GRIN2C/CAMK2D/PLCB1/CALML3/MAPK1/GNG11/GNG12/PER3/CACNA1H/ADCYAP1R1/PRKCA/GRIA2/CAMK2B	35
KEGG	hsa00515	Mannose type O-glycan biosynthesis	7/3397	23/8135	0.9077	1	0.7091	POMGNT2/FUT4/FKRP/MGAT5B/POMT1/POMT2/B4GALT1	7
KEGG	hsa04512	ECM-receptor interaction	31/3397	88/8135	0.9137	1	0.7091	FN1/ITGA5/ITGB7/ITGB5/SPP1/LAMB2/CD44/THBS3/CD36/LAMC3/COL4A2/ITGA4/ITGA7/LAMB3/ITGA11/CD47/ITGA2/VWF/ITGA3/COL2A1/LAMA2/COL4A3/TNXB/ITGA8/COL6A3/DSPP/RELN/DAG1/IBSP/LAMA1/SV2B	31
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	27/3397	78/8135	0.9205	1	0.7091	EPHX1/ADH5/MGST2/GSTP1/AKR7A2/CYP1B1/AKR7A3/DHDH/AKR1C1/CYP2S1/GSTO1/HSD11B1/GSTA1/GSTM3/MGST1/CYP2D6/CYP1A2/CBR3/GSTM5/HPGDS/GSTM4/ADH1B/MGST3/HSD11B1L/CYP2A6/ALDH3A1/ADH7	27
KEGG	hsa04020	Calcium signaling pathway	90/3397	240/8135	0.9234	1	0.7091	SLC8A1/HTR2B/ATP2B4/MCOLN1/FLT1/TPCN1/VEGFB/CAMK1D/GNA15/ORAI2/P2RX7/PRKACB/PPP3CB/ITPR1/HGF/PTAFR/GNAQ/PTK2B/MCU/RYR1/PDGFC/ADRB1/VEGFA/STIM2/PLCG2/CYSLTR1/PHKB/ADCY7/ORAI3/PDGFB/SLC25A5/FGF1/PHKG1/ADCY1/SPHK1/P2RX1/ADORA2B/ADCY3/HTR4/TNNC2/PRKACA/ADRB2/VDAC2/PDGFA/MCOLN2/CAMK2A/CHRM2/F2R/GRIN2C/VDAC1/PLCD1/GRPR/MYLK/CAMK2D/PLCB1/MST1/EGFR/ORAI1/ATP2A2/CALML3/PLCD4/SLC8A2/TACR1/CASQ1/CASQ2/ADRA1D/HRC/HTR5A/RET/BDKRB1/VDAC3/P2RX2/MET/CCKBR/SLC8A3/MCOLN3/FGF23/CACNA1H/CACNA1F/PRKCA/ERBB3/GNA11/TACR2/NTSR1/PDGFD/NTRK2/FGF6/CAMK2B/P2RX5/CCKAR	90
KEGG	hsa04978	Mineral absorption	20/3397	60/8135	0.9293	1	0.7091	SLC8A1/SLC40A1/VDR/ATP2B4/ATP1A1/HMOX1/ATOX1/CYBRD1/FTL/ATP7B/ATP1B2/ATP1B3/ATP1B1/SLC46A1/SLC8A2/ATP1B4/ATP7A/FXYD2/ATP1A2/SLC8A3	20
KEGG	hsa00590	Arachidonic acid metabolism	20/3397	61/8135	0.9418	1	0.7091	ALOX5/PLA2G12A/PTGS2/AKR1C3/GPX7/CYP2J2/GPX3/PLB1/PTGES3/ALOX15B/PLA2G3/CBR3/HPGDS/GGT5/PLA2G6/GPX1/CYP4F3/CYP2C8/PTGS1/CYP2U1	20
KEGG	hsa04923	Regulation of lipolysis in adipocytes	18/3397	56/8135	0.9469	1	0.7091	FABP4/GNAI3/PTGS2/MGLL/PRKACB/PIK3R3/INSR/ADRB1/ADCY7/IRS2/ADCY1/ADCY3/GNAI2/PIK3CD/PRKACA/ADRB2/PTGS1/PIK3CB	18
KEGG	hsa00220	Arginine biosynthesis	6/3397	22/8135	0.9481	1	0.7091	ARG2/NAGS/GLUD1/GLUD2/GLS/GOT2	6
KEGG	hsa00430	Taurine and hypotaurine metabolism	4/3397	16/8135	0.951	1	0.7091	FMO4/GGT7/GGT5/FMO2	4
KEGG	hsa04976	Bile secretion	30/3397	89/8135	0.9525	1	0.7091	EPHX1/AQP9/ATP1A1/SCARB1/PRKACB/SLC9A1/HMGCR/SCTR/LDLR/ATP1B2/ADCY7/ADCY1/ATP1B3/RXRA/ADCY3/ATP1B1/PRKACA/ABCB4/SLC10A1/ABCB11/SLC4A5/NCEH1/ATP1B4/FXYD2/SLC22A8/ABCC3/ABCC4/ATP1A2/NR1H4/SLCO1B1	30
KEGG	hsa04913	Ovarian steroidogenesis	16/3397	51/8135	0.9525	1	0.7091	IGF1/ALOX5/PTGS2/SCARB1/PRKACB/AKR1C3/CYP1B1/INSR/CYP2J2/IGF1R/LDLR/ADCY7/ADCY1/ADCY3/PRKACA/FSHR	16
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	37/3397	109/8135	0.9622	1	0.7091	NXF1/GNL2/RPP38/RAN/EIF6/CSNK2A2/NXT1/GTPBP4/UTP14A/XRN2/CSNK2B/RPP25/NAT10/FBL/RRP7A/NHP2/UTP15/XRN1/REXO2/LSG1/GAR1/RPP25L/WDR36/RCL1/NXT2/WDR75/RIOK2/AK6/RPP40/IMP4/GNL3L/FBLL1/POP7/DROSHA/MDN1/NOP10/GNL3	37
KEGG	hsa00982	Drug metabolism - cytochrome P450	23/3397	72/8135	0.9669	1	0.7091	ADH5/MGST2/GSTP1/FMO4/MAOA/GSTO1/GSTA1/GSTM3/MGST1/CYP2D6/CYP1A2/GSTM5/HPGDS/GSTM4/ADH1B/MAOB/MGST3/FMO2/AOX1/CYP2A6/ALDH3A1/ADH7/CYP2C8	23
KEGG	hsa04727	GABAergic synapse	29/3397	89/8135	0.9708	1	0.7091	GABBR1/GNAI3/GNB1/GNB2/GNG5/PRKACB/GNG7/TRAK2/ADCY7/GNG2/GNB3/SLC38A1/ADCY1/PLCL1/ADCY3/GNAI2/PRKACA/GLS/GNB4/GNG11/GABARAPL1/GNG12/SLC6A13/GABRA4/SLC6A12/SLC38A5/CACNA1F/PRKCA/GABRP	29
KEGG	hsa00040	Pentose and glucuronate interconversions	9/3397	34/8135	0.9789	1	0.7091	AKR1B1/CRYL1/RPE/AKR1A1/DHDH/GUSB/SORD/AKR1B10/KL	9
KEGG	hsa04975	Fat digestion and absorption	12/3397	43/8135	0.9794	1	0.7091	SLC27A1/PLA2G12A/SCARB1/CD36/ABCA1/DGAT2/PLA2G3/GOT2/APOA1/PNLIPRP1/AGPAT1/AGPAT2	12
KEGG	hsa05032	Morphine addiction	29/3397	91/8135	0.9801	1	0.7091	KCNJ5/GABBR1/GNAI3/GNB1/GNB2/GNG5/PRKACB/GRK6/GRK5/GNG7/ARRB1/PDE4B/ADCY7/GNG2/GNB3/ADCY1/ADCY3/GNAI2/PDE7A/PRKACA/GNB4/GNG11/GRK4/GNG12/PDE8A/GABRA4/PRKCA/GABRP/PDE8B	29
KEGG	hsa04924	Renin secretion	21/3397	69/8135	0.9807	1	0.7091	PTGER4/PTGER2/GNAI3/PRKACB/PPP3CB/ITPR1/GNAQ/ADRB1/CTSB/CREB1/GNAI2/PRKACA/ADRB2/PLCB1/ORAI1/CALML3/CLCA1/REN/KCNMA1/CACNA1F/ADCYAP1R1	21
KEGG	hsa05171	Coronavirus disease - COVID-19	82/3397	232/8135	0.9818	1	0.7091	MYD88/FOS/TLR2/MAPK12/STAT3/NLRP3/STAT1/IFNAR1/TNF/NFKBIA/CXCL10/NFKB1/PIK3R3/RELA/MX2/IRAK4/IRF9/MAPK13/TRAF6/CFD/IKBKG/TLR4/DDX58/TRAF3/OAS3/RPL36AL/NFKBIB/IL1B/PLCG2/FAU/RPL8/OAS2/ISG15/IL6ST/RPS24/MAVS/IL6/RPL22L1/RPS21/RPS9/RPS19/C3AR1/IFIH1/MAPK8/NRP1/PIK3CD/TYK2/MX1/MMP3/CASP1/MMP1/CYBB/C1R/VWF/EIF2AK2/EGFR/ADAM17/TLR8/MAPK1/CFB/RPL24/C1QC/RPS16/RPS12/JAK1/MAPK11/HBEGF/RPL26L1/FCGR2A/TLR3/RPL32/IFNAR2/IL12B/ADAR/CHUK/MASP2/RPL3L/PRKCA/PIK3CB/MAPK9/C7/RPL10A	82
KEGG	hsa00591	Linoleic acid metabolism	7/3397	29/8135	0.9854	1	0.7091	PLA2G12A/CYP2J2/PLB1/PLA2G3/CYP1A2/PLA2G6/CYP2C8	7
KEGG	hsa04950	Maturity onset diabetes of the young	6/3397	26/8135	0.9863	1	0.7091	PDX1/HES1/HNF1B/HNF1A/IAPP/PAX4	6
KEGG	hsa05150	Staphylococcus aureus infection	30/3397	96/8135	0.9873	1	0.7091	ITGAM/FPR2/FPR1/FCGR1A/FCGR3B/DEFB1/FCAR/PTAFR/ITGAL/CFD/HLA-DPB1/HLA-DPA1/FCGR2C/HLA-DMB/HLA-DOB/KRT36/HLA-DRA/HLA-DMA/SELPLG/C3AR1/KRT10/KRT23/C1R/CFB/C1QC/KRT27/FCGR2A/KRT14/MASP2/HLA-DOA	30
KEGG	hsa00830	Retinol metabolism	20/3397	68/8135	0.9873	1	0.7091	ALDH1A1/RDH10/ADH5/RETSAT/DHRS3/DHRS9/RDH16/CYP2S1/RDH12/CYP1A2/CYP26B1/RDH5/ADH1B/CYP26A1/CYP2W1/AOX1/CYP2A6/ADH7/CYP2C8/PNPLA4	20
KEGG	hsa00053	Ascorbate and aldarate metabolism	7/3397	30/8135	0.9895	1	0.7091	ALDH3A2/ALDH9A1/ALDH7A1/AKR1A1/ALDH2/GUSB/KL	7
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	20/3397	69/8135	0.99	1	0.7091	EPHX1/PTGS2/MGST2/GSTP1/CYP1B1/GSTO1/HSD11B1/GSTA1/GSTM3/MGST1/CYP1A2/GSTM5/HPGDS/GSTM4/MGST3/HSD11B1L/NAT2/NAT1/CYP2A6/CYP2C8	20
KEGG	hsa00910	Nitrogen metabolism	3/3397	17/8135	0.9916	1	0.7091	CA5B/GLUD1/GLUD2	3
KEGG	hsa04970	Salivary secretion	28/3397	93/8135	0.9926	1	0.7091	KCNN4/ATP2B4/BST1/ATP1A1/PRKACB/SLC9A1/CST3/ITPR1/GNAQ/ADRB1/ATP1B2/ADCY7/ADCY1/ATP1B3/SLC12A2/ADCY3/ATP1B1/PRKACA/ADRB2/DMBT1/PLCB1/CALML3/ATP1B4/ADRA1D/FXYD2/KCNMA1/ATP1A2/PRKCA	28
KEGG	hsa04613	Neutrophil extracellular trap formation	62/3397	190/8135	0.9964	1	0.7091	ITGAM/FPR2/FPR1/TLR2/RAC2/MAPK12/CLEC7A/ATG7/AQP9/FCGR1A/AZU1/FCGR3B/MAP2K1/HAT1/NFKB1/PIK3R3/RELA/ACTB/ITGAL/NCF4/MAPK13/NCF2/NCF1/TLR4/CLCN3/AGER/HDAC11/PLCG2/HMGB1/RAF1/RAC1/SLC25A5/CR1/SELPLG/HDAC10/HDAC2/HDAC7/HDAC4/PIK3CD/CASP1/MAP2K2/VDAC2/CYBA/CYBB/VWF/VDAC1/PLCB1/CASP4/TLR8/MAPK1/CLCN4/MAPK11/CTSG/FCGR2A/VDAC3/MTOR/HDAC5/CLCN5/MPO/PRKCA/SIGLEC9/PIK3CB	62
KEGG	hsa00860	Porphyrin metabolism	10/3397	43/8135	0.9966	1	0.7091	BLVRB/FECH/HMOX1/UROD/ALAD/CPOX/GUSB/MMAB/COX15/ALAS1	10
KEGG	hsa04270	Vascular smooth muscle contraction	40/3397	134/8135	0.9984	1	0.7091	KCNMB1/PLA2G12A/MAP2K1/PRKACB/MYL6B/ITPR1/GNAQ/PRKCD/PPP1R14A/ACTA2/ARAF/RAF1/ADCY7/MRVI1/MYL6/ADCY1/MYH9/PLA2G3/ADORA2B/ADCY3/PRKACA/MAP2K2/MYLK/PPP1CC/PLCB1/PPP1CA/CALML3/MAPK1/GNA13/PLA2G6/ADRA1D/PPP1CB/PRKCQ/KCNMA1/RHOA/KCNMB4/ROCK2/CACNA1F/PRKCA/GNA11	40
KEGG	hsa04724	Glutamatergic synapse	32/3397	114/8135	0.9992	1	0.7091	GNAI3/GNB1/GNB2/GNG5/PRKACB/PLD1/GNG7/PPP3CB/ITPR1/GNAQ/HOMER3/HOMER1/ADCY7/GNG2/GNB3/SLC38A1/ADCY1/ADCY3/GNAI2/PRKACA/SHANK1/GLS/GNB4/GRIN2C/PLCB1/PLD2/MAPK1/GNG11/GNG12/SHANK3/PRKCA/GRIA2	32
KEGG	hsa04744	Phototransduction	4/3397	29/8135	0.9998	1	0.7091	GNB1/PDE6G/CALML3/GUCY2D	4
KEGG	hsa04742	Taste transduction	21/3397	86/8135	0.9998	1	0.7091	PKD2L1/GABBR1/PRKACB/HTR1F/TAS2R4/GNB3/HCN4/PRKACA/TAS2R50/PLCB1/TAS2R8/P2RY4/TAS2R7/HTR3B/SCN9A/SCN3A/GABRA4/P2RX2/TAS2R9/P2RY1/HTR3A	21
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	14/3397	66/8135	0.9999	1	0.7091	PARS2/SEPSECS/NARS2/LARS2/PSTK/IARS2/MARS2/HARS2/MTFMT/YARS2/DARS2/QRSL1/AARS2/WARS2	14
KEGG	hsa00140	Steroid hormone biosynthesis	12/3397	61/8135	0.9999	1	0.7091	SRD5A1/AKR1C3/CYP1B1/AKR1C1/HSD11B1/CYP1A2/STS/SRD5A3/HSD17B3/HSD11B1L/LRTOMT/HSD17B12	12
KEGG	hsa05033	Nicotine addiction	6/3397	40/8135	0.9999	1	0.7091	GRIN2C/CHRNA4/CHRNB2/GABRA4/GRIA2/GABRP	6
KEGG	hsa05034	Alcoholism	52/3397	187/8135	1	1	0.7091	SLC29A1/SLC29A3/FOSB/GNAI3/GNB1/GNB2/MAP2K1/GNG5/PRKACB/HAT1/KRAS/ATF4/GNG7/CREB5/MAOA/HRAS/CREB3L2/HDAC11/ARAF/SHC1/CREB1/RAF1/GNG2/CREB3L4/GNB3/HDAC10/HDAC2/HDAC7/ADORA2B/GNAI2/HDAC4/PRKACA/NRAS/CREB3/GRB2/SLC29A2/GNB4/GRIN2C/PPP1CC/PPP1CA/CALML3/MAOB/MAPK1/GNG11/PPP1CB/GNG12/PKIA/HDAC5/SHC3/SHC4/ATF6B/NTRK2	52
KEGG	hsa05206	MicroRNAs in cancer	91/3397	310/8135	1	1	0.7091	BMF/EZR/CDKN1A/STMN1/NOTCH2/ITGA5/STAT3/PIM1/VIM/PTGS2/MAP2K1/CD44/MYC/SLC45A3/EZH2/HMOX1/NFKB1/KRAS/ZEB2/PIK3R3/CCND2/NOTCH3/RDX/CYP1B1/MARCKS/MAPK7/HNRNPK/MCL1/CCNG1/VEGFA/CASP3/HRAS/ABL1/PLCG2/SHC1/CRK/RAF1/SIRT1/CCND1/IRS2/PDGFB/ATM/MIR34A/SLC7A1/DICER1/HDAC2/BCL2L11/MMP9/CCNE1/BCL2/TPM1/HDAC4/PIK3CD/CDKN1B/NRAS/CDC25A/MAP2K2/GRB2/PDGFA/DDIT4/GLS/BRCA1/EGFR/DNMT3A/SPRY2/FSCN1/MDM2/MAPK1/NOTCH4/SOCS1/TNXB/UBE2I/MTOR/HDAC5/FOXP1/RHOA/PDCD4/SOX4/EFNA2/MET/BAK1/MMP16/BCL2L2/SHC4/PRKCA/ERBB3/MIR205/PIK3CB/EFNA3/BMPR2/MIR146A	91
KEGG	hsa03010	Ribosome	33/3397	158/8135	1	1	0.7091	MRPS6/MRPL35/MRPL34/RPL36AL/MRPS16/FAU/RPL8/MRPS14/RPS24/RPL22L1/MRPL33/RPS21/RPS9/RPS19/MRPL3/MRPL4/RPL24/MRPL20/RPS16/RPS12/MRPL24/MRPL36/RPL26L1/MRPS15/RPL32/MRPL2/MRPS2/MRPS9/RPL3L/MRPL30/MRPL1/RPL10A/MRPS17	33
KEGG	hsa04080	Neuroactive ligand-receptor interaction	97/3397	353/8135	1	1	0.7091	FPR2/HTR2B/FPR1/PTGER4/S1PR4/GABBR1/S1PR3/PTGER2/THRA/P2RY14/S1PR1/P2RY8/P2RX7/HTR1F/PTAFR/LPAR2/LEP/P2RY6/SCTR/ADRB1/GZMA/VIPR1/CYSLTR1/CHRNA2/LPAR6/PRSS3/C3AR1/P2RX1/NMUR2/ADORA2B/HTR4/CHRNA10/P2RY13/LPAR3/ADRB2/CHRNG/UTS2B/CNR2/LPAR1/CHRM2/F2R/GRIN2C/NPB/CHRNA4/PMCH/GRPR/KISS1R/NMB/NPBWR1/INSL3/GIPR/TACR1/GPHB5/GPR35/GALR1/CHRNB2/P2RY4/HCRTR1/GPHA2/ADRA1D/HTR5A/VIP/BDKRB1/OPRD1/FSHR/CTSG/RXFP2/OPRL1/SLURP1/CHRNE/P2RY10/GHRH/GABRA4/IAPP/P2RX2/ADORA3/GPR50/CCKBR/GCG/GHR/NMBR/ADCYAP1R1/UCN3/GRIA2/GABRP/P2RY1/AVPR2/S1PR5/PRSS2/TACR2/NTSR1/GHRL/KISS1/NTSR2/APLN/P2RX5/CCKAR	97
KEGG	hsa05322	Systemic lupus erythematosus	24/3397	136/8135	1	1	0.7091	FCGR1A/CD40/FCGR3B/ACTN4/TNF/ACTN1/HLA-DPB1/HLA-DPA1/SNRPB/HLA-DMB/HLA-DOB/HLA-DRA/HLA-DMA/SNRPD1/TRIM21/C1R/SSB/C1QC/IFNG/CTSG/FCGR2A/CD80/HLA-DOA/C7	24
KEGG	hsa04740	Olfactory transduction	38/3397	440/8135	1	1	0.7091	SLC8A1/GNB1/RGS2/PRKACB/GNG7/ARRB1/OR7C2/OR6B1/OR14J1/ADCY3/OR1D2/PRKACA/OR12D2/OR7A17/OR5I1/CAMK2A/CAMK2D/OR1A1/CALML3/OR13C4/SLC8A2/OR2S2/OR7A10/GUCY2D/OR10H2/SLC24A4/OR8D1/OR2H2/OR1F1/OR51B4/OR10H1/SLC8A3/OR2F1/OR10A3/OR51M1/OR1E1/CAMK2B/OR2B6	38