ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
KEGG	hsa05168	Herpes simplex virus 1 infection	160/1562	495/8135	4.857e-13	1.617e-10	1.457e-10	ZFP69/NFKBIA/ZNF420/ZNF559/ZNF860/SOCS3/ZNF354B/ZNF253/ZNF124/ZNF596/ZNF792/ZNF181/ZNF25/ZNF425/ZNF786/ZNF226/ZNF470/ZNF569/ZNF799/ZNF343/DAXX/ZNF514/ZNF382/ZNF705D/ZNF415/OAS1/ZNF233/OAS2/SRSF3/ZNF670/ZNF605/ZNF41/ZNF573/RHEB/ZNF320/ZNF2/ZNF613/ZNF630/ZNF780B/SRSF1/ZNF74/ZNF544/ZNF419/HLA-B/ZNF248/ZNF768/ZNF772/ZSCAN32/ZNF674/ZNF404/TLR9/ZNF302/NFKB1/ZNF534/AKT3/HLA-DOB/ZNF416/ZNF585B/ZNF578/ZNF234/ZNF701/POU2F2/ZNF33B/SRSF6/ZNF684/ZIK1/ZNF765/ZNF566/ZNF443/ZNF235/ZNF658/ZNF607/HLA-DRA/ZNF311/DDX58/ZNF324/ZNF200/ZNF519/ZNF721/ZNF229/HLA-DOA/ZNF540/ZNF141/ZNF100/ZNF30/HLA-DMB/ZNF570/HLA-DPA1/IKBKB/ZFP1/ZNF418/PIK3CD/ZNF568/ZNF558/ZNF549/ZNF354A/ZNF12/ZNF676/ZNF813/RNASEL/TRAF6/ZNF317/PIK3CA/HLA-E/ZNF337/IRF3/ZNF680/ZNF585A/BIRC3/ZNF606/ZNF230/ZNF99/TRAF5/HLA-A/ZNF616/ZNF250/TRADD/ALYREF/ZNF675/ZNF816/MAVS/ZNF398/TSC1/ZNF169/ZNF552/PPP1CA/ZNF93/IKBKE/TAP1/HLA-F/ZNF718/ZNF107/ZNF225/ZNF275/ZNF175/IFNA1/ZNF227/HLA-DPB1/ZNF37A/ZNF331/ZNF208/ZNF221/ZFP90/ZNF473/ZNF528/ZNF17/ZNF808/ZNF773/ZNF619/ZNF623/ZNF782/ZNF543/ZNF556/EIF2S1/STAT2/ZNF441/ZNF550/ZNF160/ZNF479/HLA-DQA1	160
KEGG	hsa05169	Epstein-Barr virus infection	65/1562	202/8135	6.092e-06	0.001014	0.0009137	NFKBIA/CDKN1A/TNFAIP3/GADD45B/OAS1/OAS2/NFKBIB/BCL2L11/CIR1/HLA-B/NFKBIE/NFKB1/AKT3/HLA-DOB/NEDD4/MAP2K6/HDAC1/PSMD4/HLA-DRA/CCND1/HDAC2/CR2/HES1/DDX58/PLCG2/MDM2/POLK/ENTPD1/RIPK1/HLA-DOA/HLA-DMB/MAPK8/JUN/HLA-DPA1/IKBKB/PIK3CD/RELB/PSMC2/TRAF6/PIK3CA/HLA-E/IRF3/CDK4/TRAF5/HLA-A/CD44/TRADD/BTK/CCND3/MAVS/IKBKE/TAP1/HLA-F/SIN3A/IFNA1/HLA-DPB1/CD19/LYN/BLNK/RBPJ/CD40/STAT2/CCNA2/PSMD7/HLA-DQA1	65
KEGG	hsa04662	B cell receptor signaling pathway	30/1562	82/8135	0.0001619	0.01797	0.01619	NFKBIA/RAC2/PTPN6/FOS/NFKBIB/LILRA4/CD79B/NFKBIE/NFKB1/AKT3/DAPP1/INPP5D/CR2/PLCG2/JUN/IKBKB/PIK3CD/PIK3CA/CD81/MAPK1/FCGR2B/BTK/GRB2/CD19/LYN/NFATC2/VAV2/BLNK/LILRB1/CD72	30
KEGG	hsa04146	Peroxisome	29/1562	82/8135	0.0004026	0.03181	0.02866	SOD2/HMGCL/HSD17B4/PXMP4/DAO/PRDX1/MPV17/MLYCD/CAT/PMVK/PEX5L/ECI2/IDH1/SOD1/PEX6/ACOX3/ACSL5/XDH/PEX11B/EPHX2/MPV17L/NUDT12/GNPAT/ACSL6/ABCD4/PEX10/DHRS4/SLC25A17/PIPOX	29
KEGG	hsa05162	Measles	43/1562	139/8135	0.0005702	0.03181	0.02866	NFKBIA/TNFAIP3/FOS/HSPA8/BBC3/OAS1/HSPA1B/OAS2/HSPA1A/IL2RG/CSNK2A1/NFKBIB/TLR9/NFKB1/IL2RA/AKT3/RAB9B/CCND1/STAT5B/DDX58/MX1/TP73/SLAMF1/MAPK8/JUN/IKBKB/PIK3CD/TRAF6/PIK3CA/IRF3/FCGR2B/CDK4/TRADD/CCND3/EIF3H/MAVS/CSNK2A3/IKBKE/IFNA1/HSPA1L/MX2/EIF2S1/STAT2	43
KEGG	hsa00020	Citrate cycle (TCA cycle)	14/1562	30/8135	0.0005732	0.03181	0.02866	SDHD/SDHA/MDH1/FH/PDHB/IDH1/PCK2/SUCLG2/DLAT/SDHC/PDHA1/SDHB/SUCLG1/DLST	14
KEGG	hsa04140	Autophagy - animal	42/1562	141/8135	0.001517	0.07215	0.065	HIF1A/IRS2/PPP2CA/ATG2A/HMGB1/RHEB/ATG12/ATG4A/VAMP8/AKT3/ATG10/C9orf72/GABARAPL1/RB1CC1/ATG13/MAP1LC3B/RAB39B/SQSTM1/RAB1A/ATG4C/MAPK8/PIK3CD/DDIT4/GABARAPL2/TRAF6/PIK3CA/ATG9A/MAPK1/PRKACB/RAB7A/MTMR4/ULK1/TSC1/TP53INP2/PTEN/IRS1/ATG7/RAB8A/PRKCD/EIF2S1/STK11/STX17	42
KEGG	hsa04145	Phagosome	44/1562	152/8135	0.002216	0.08607	0.07754	M6PR/CORO1A/ATP6V0E1/TUBB2A/ATP6V1B1/ATP6V1D/EEA1/CYBA/HLA-B/ACTG1/TUBB4A/TUBB2B/HLA-DOB/STX7/MRC1/TUBB4B/HLA-DRA/NCF1/RAB5B/HLA-DOA/HLA-DMB/ATP6V1G3/HLA-DPA1/SEC22B/ATP6V1G1/HLA-E/SEC61G/DYNC1I2/ATP6V1F/NCF4/FCGR2B/RAB7A/ATP6V1A/HLA-A/SEC61A2/DYNC1I1/TAP1/HLA-F/HLA-DPB1/C1R/RAB5C/COLEC11/MSR1/HLA-DQA1	44
KEGG	hsa00280	Valine, leucine and isoleucine degradation	18/1562	48/8135	0.002326	0.08607	0.07754	HIBCH/HMGCL/DBT/IVD/ACADSB/HIBADH/AUH/ACAD8/ACADM/ALDH7A1/BCAT2/MCEE/HADHB/ACAT1/HADH/BCKDHB/ALDH3A2/ALDH1B1	18
KEGG	hsa05132	Salmonella infection	66/1562	249/8135	0.002613	0.08701	0.07839	NFKBIA/CDC42/KIF5C/FOS/M6PR/TUBB2A/MYL12A/PTPRC/ARF1/CASP4/ARPC3/TNFSF10/ACTG1/TUBB4A/TLR9/ACBD3/NFKB1/TUBB2B/AKT3/PIK3C2G/RAB9B/MAP2K6/ARPC5/KIF5A/DYNLL2/PLEKHM2/MYL12B/TUBB4B/ACTR2/RIPK2/RHOG/RIPK1/CTNNB1/RAB5B/MAPK8/JUN/IKBKB/PIK3CD/TRAF6/PIK3CA/DYNC1I2/MAPK1/BIRC3/DYNLT1/ROCK2/CASP1/BRK1/RAB7A/TRADD/HSP90B1/GSDMD/EXOC2/DYNLL1/DYNC1I1/ACTR3B/SNX9/KIF5B/HSP90AB1/RAB5C/FYCO1/LY96/DCTN6/RHOJ/HSP90AA1/MYL7/VPS33A	66
KEGG	hsa03410	Base excision repair	13/1562	33/8135	0.005647	0.1584	0.1427	POLD3/UNG/HMGB1/MBD4/OGG1/APEX2/PARP1/POLD4/PCNA/POLL/NTHL1/APEX1/SMUG1	13
KEGG	hsa04659	Th17 cell differentiation	32/1562	108/8135	0.005707	0.1584	0.1427	NFKBIA/HIF1A/IL6ST/FOS/IL2RG/NFKBIB/NFKBIE/NFKB1/IL2RA/HLA-DOB/STAT6/HLA-DRA/STAT5B/HLA-DOA/HLA-DMB/MAPK8/JUN/HLA-DPA1/IKBKB/RXRB/RARA/AHR/MAPK1/HLA-DPB1/HSP90AB1/SMAD3/NFATC2/TBX21/HSP90AA1/SMAD2/EBI3/HLA-DQA1	32
KEGG	hsa05014	Amyotrophic lateral sclerosis	89/1562	364/8135	0.006703	0.1717	0.1547	PSMA8/NXT1/HSPA5/DDIT3/KIF5C/ATF4/UQCRFS1/ERBB4/DAXX/TUBB2A/UQCR10/ATG2A/SDHD/SRSF3/COX4I1/NUP210L/NUP43/NDUFB3/ACTG1/NEFL/TUBB4A/SDHA/DNAI2/DNAL4/TUBB2B/MAP2K6/RANBP2/XBP1/KIF5A/CAT/C9orf72/NDUFA8/RB1CC1/NDUFS2/NRG3/DNAH5/NDUFB1/ATG13/ATXN2/PSMD4/TUBB4B/SOD1/NDUFB5/HNRNPA2B1/MAP1LC3B/RAB39B/SQSTM1/NUP37/MATR3/RAB1A/CYC1/NUP153/PSMA7/SDHC/PSMC2/PSMB2/CASP1/NRG4/ALYREF/VAPB/COX7C/ULK1/DNAL1/NEFH/CASP12/DNAH2/DNAH10/ANXA7/CCS/DNAH9/GRIA2/NEFM/COX6B2/SDHB/KIF5B/HNRNPA1/PSMA3/COX7A2L/NDUFA7/RAB8A/DNAH6/HNRNPA1L2/DCTN6/DNAH3/UBQLN4/EIF2S1/NDUFA12/MAP3K5/PSMD7	89
KEGG	hsa05166	Human T-cell leukemia virus 1 infection	57/1562	222/8135	0.009936	0.23	0.2072	NFKBIA/CDKN1A/ATF4/FOS/TGFB3/ANAPC16/ZFP36/CHEK2/CREB3L4/VDAC3/ANAPC15/VDAC2/IL2RG/TLN2/HLA-B/NFKB1/IL2RA/AKT3/HLA-DOB/ETS1/FDPS/HLA-DRA/CCND1/RANBP1/STAT5B/CDC26/HLA-DOA/HLA-DMB/MAPK8/JUN/HLA-DPA1/IKBKB/PIK3CD/RELB/PIK3CA/HLA-E/MAPK1/PRKACB/CDK4/HLA-A/CCND3/ANAPC7/HLA-F/PTEN/CDC23/HLA-DPB1/ADCY2/SMAD3/NFATC2/SRF/CD40/CRTC1/SMAD2/EP300/ELK4/CCNA2/HLA-DQA1	57
KEGG	hsa03018	RNA degradation	24/1562	79/8135	0.01116	0.23	0.2072	BTG3/DCP1A/HSPA9/CNOT7/EXOSC6/DCP1B/PABPC4/EXOSC1/PABPC1/TOB2/EXOSC2/ENO4/BTG1/LSM6/DIS3L/EXOSC5/DDX6/LSM2/PFKL/WDR61/PABPC3/EXOSC3/LSM5/DCPS	24
KEGG	hsa00620	Pyruvate metabolism	16/1562	47/8135	0.01151	0.23	0.2072	LDHB/MDH1/FH/PDHB/ADH6/PCK2/ACSS1/DLAT/ALDH7A1/PDHA1/ACYP1/GLO1/GRHPR/ACAT1/ALDH3A2/ALDH1B1	16
KEGG	hsa00330	Arginine and proline metabolism	17/1562	51/8135	0.01174	0.23	0.2072	SAT1/ALDH4A1/DAO/ODC1/ALDH18A1/MAOB/ALDH7A1/GATM/GOT2/L3HYPDH/PYCR2/MAOA/CNDP2/CKMT1A/ALDH3A2/ALDH1B1/ARG2	17
KEGG	hsa05220	Chronic myeloid leukemia	23/1562	76/8135	0.01344	0.2486	0.224	NFKBIA/CDKN1A/GADD45B/TGFB3/NFKB1/AKT3/MECOM/HDAC1/CCND1/HDAC2/STAT5B/MDM2/POLK/SHC3/IKBKB/PIK3CD/CRK/PIK3CA/MAPK1/CTBP1/CDK4/GRB2/SMAD3	23
KEGG	hsa02010	ABC transporters	15/1562	45/8135	0.01737	0.2919	0.2629	ABCB11/ABCB7/ABCC9/ABCA12/ABCC5/ABCA4/ABCC11/ABCA10/ABCB5/TAP1/ABCB6/ABCA1/ABCG2/ABCA13/ABCD4	15
KEGG	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1562	26/8135	0.01753	0.2919	0.2629	PIGM/PIGN/PIGA/PIGF/PIGV/GPLD1/PIGU/PIGB/DPM2/PIGO	10
KEGG	hsa04621	NOD-like receptor signaling pathway	47/1562	184/8135	0.01972	0.2959	0.2665	NFKBIA/TNFAIP3/NAMPT/VDAC3/OAS1/OAS2/VDAC2/NFKBIB/CASP4/CYBA/ATG12/BRCC3/NFKB1/GABARAPL1/MAP1LC3B/IFI16/RIPK2/RIPK1/NLRX1/MAPK8/JUN/IKBKB/TRPV2/SUGT1/AIM2/GABARAPL2/RNASEL/TRAF6/IRF3/ANTXR1/MAPK1/BIRC3/TXNIP/CASP1/TRAF5/MAVS/GSDMD/CASP12/IKBKE/DHX33/IFNA1/HSP90AB1/PRKCD/HSP90AA1/STAT2/GPRC6A/NEK7	47
KEGG	hsa04141	Protein processing in endoplasmic reticulum	44/1562	171/8135	0.02081	0.2959	0.2665	HSPA5/UBE2D3/DDIT3/ATF4/HSPA8/HERPUD1/HSPA1B/HSPA1A/PPP1R15A/CAPN1/UBE2D2/XBP1/ERP29/DERL2/HSPA4L/UBE2J2/SAR1A/MAPK8/DAD1/HSPH1/DNAJB11/RNF5/SEC61G/HYOU1/EDEM3/HSP90B1/PREB/FBXO2/CASP12/SVIP/SEC61A2/UBXN8/HSP90AB1/HSPA1L/ATXN3/SEL1L/DNAJC5B/SEC24C/UBQLN4/SEC62/HSP90AA1/EIF2S1/SSR4/MAP3K5	44
KEGG	hsa04068	FoxO signaling pathway	35/1562	131/8135	0.0213	0.2959	0.2665	CDKN1A/IRS2/GADD45B/TGFB3/SOD2/KLF2/PRMT1/BCL2L11/ATG12/S1PR4/TNFSF10/AKT3/BCL6/CAT/GABARAPL1/SETD7/CCND1/MDM2/PCK2/INSR/MAPK8/IKBKB/PIK3CD/GABARAPL2/NLK/PIK3CA/MAPK1/SGK1/FOXG1/PTEN/GRB2/IRS1/SMAD3/EP300/STK11	35
KEGG	hsa04930	Type II diabetes mellitus	15/1562	46/8135	0.02132	0.2959	0.2665	SOCS3/IRS2/CACNA1B/CACNA1A/CACNA1C/INSR/MAPK8/CACNA1G/IKBKB/PIK3CD/PIK3CA/MAPK1/IRS1/PRKCD/ADIPOQ	15
KEGG	hsa04210	Apoptosis	36/1562	136/8135	0.02267	0.297	0.2676	NFKBIA/PMAIP1/DDIT3/ATF4/FOS/GADD45B/BBC3/DAXX/CASP2/CAPN1/BCL2L11/TNFSF10/ACTG1/NFKB1/AKT3/CASP10/RIPK1/MAPK8/JUN/IKBKB/CTSC/PIK3CD/HTRA2/PARP1/PIK3CA/MAPK1/BIRC3/TRADD/CTSO/CASP12/AIFM1/SPTAN1/EIF2S1/CASP6/MAP3K5/ENDOG	36
KEGG	hsa03250	Viral life cycle - HIV-1	19/1562	63/8135	0.02416	0.297	0.2676	ELL2/APOBEC3F/CXCR4/RANBP2/TRIM5/CHMP4A/APOBEC3C/BICD2/MX1/PSIP1/NUP153/BICD1/APOBEC3G/SERINC3/APOBEC3D/ELL3/PDCD6IP/MX2/EP300	19
KEGG	hsa05208	Chemical carcinogenesis - reactive oxygen species	55/1562	223/8135	0.02446	0.297	0.2676	NFKBIA/HIF1A/FOS/UQCRFS1/SOD2/UQCR10/VDAC3/SDHD/COX4I1/VDAC2/NDUFB3/CYBA/NQO1/SDHA/NFKB1/AKT3/CAT/NDUFA8/GSTM5/NDUFS2/PPIF/NDUFB1/SOD1/NDUFB5/NCF1/GSTT1/CYC1/MAPK8/PRKD1/KEAP1/JUN/IKBKB/PIK3CD/SDHC/PIK3CA/AHR/MAPK1/CBR1/COX7C/EPHX2/ARNT/PTEN/COX6B2/GRB2/SDHB/PLD1/CYP2F1/GSTA1/COX7A2L/GSTM4/NDUFA7/PRKCD/PRKD3/NDUFA12/MAP3K5	55
KEGG	hsa04380	Osteoclast differentiation	34/1562	128/8135	0.02498	0.297	0.2676	NFKBIA/JUNB/SOCS3/FOS/CYLD/LILRA4/CYBA/NFKB1/CALCR/AKT3/MAP2K6/JUND/ACP5/PLCG2/SQSTM1/NCF1/FOSL2/MAPK8/JUN/IKBKB/PIK3CD/RELB/FOSB/TRAF6/PIK3CA/NCF4/MAPK1/FCGR2B/BTK/GRB2/NFATC2/BLNK/LILRB1/STAT2	34
KEGG	hsa04137	Mitophagy - animal	21/1562	72/8135	0.02659	0.3054	0.2751	HIF1A/UBC/TFEB/ATF4/CSNK2A1/USP30/GABARAPL1/MAP1LC3B/TOMM7/SQSTM1/MAPK8/JUN/NBR1/GABARAPL2/ATG9A/RAB7A/ULK1/BNIP3L/CSNK2A3/RHOT1/FUNDC1	21
KEGG	hsa05130	Pathogenic Escherichia coli infection	49/1562	197/8135	0.02801	0.3109	0.2801	NLRP4/NFKBIA/GNA13/CDC42/PTPN6/FOS/LPAR5/TUBB2A/NFKBIB/ARF1/CASP4/ARPC3/TNFSF10/ACTG1/TUBB4A/MYH10/NFKB1/TUBB2B/ARPC5/WIPF3/CLDN11/WIPF1/ARHGEF2/MYO1H/HCLS1/TUBB4B/ACTR2/RIPK1/RAB1A/MAPK8/JUN/IKBKB/PAK2/MYO1G/TRAF6/MAPK1/CLDN19/MYO5B/ROCK2/CASP1/BRK1/ABCF2/TRADD/CLDN7/LPAR4/GNA12/ACTR3B/MYH11/SEC24C	49
KEGG	hsa00640	Propanoate metabolism	11/1562	32/8135	0.03109	0.3112	0.2803	HIBCH/LDHB/MLYCD/DBT/ECHDC1/ACSS1/SUCLG2/ACOX3/MCEE/SUCLG1/BCKDHB	11
KEGG	hsa04136	Autophagy - other	11/1562	32/8135	0.03109	0.3112	0.2803	PPP2CA/ATG2A/ATG12/ATG4A/ATG10/GABARAPL1/ATG13/ATG4C/GABARAPL2/ATG9A/ATG7	11
KEGG	hsa03030	DNA replication	12/1562	36/8135	0.03163	0.3112	0.2803	POLD3/DNA2/MCM3/RNASEH2B/RPA2/RNASEH2C/RFC2/RNASEH2A/RNASEH1/POLD4/PRIM1/PCNA	12
KEGG	hsa00260	Glycine, serine and threonine metabolism	13/1562	40/8135	0.03177	0.3112	0.2803	DAO/ALAS1/SHMT2/MAOB/DMGDH/ALDH7A1/GATM/PGAM2/GRHPR/BPGM/MAOA/PHGDH/PIPOX	13
KEGG	hsa04612	Antigen processing and presentation	22/1562	78/8135	0.03404	0.3162	0.2848	HSPA5/HSPA8/HSPA1B/HSPA1A/HLA-B/HLA-DOB/RFXAP/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/HLA-A/NFYC/TAP1/HLA-F/HLA-DPB1/HSP90AB1/HSPA1L/HSP90AA1/KIR3DL3/HLA-DQA1	22
KEGG	hsa04144	Endocytosis	60/1562	251/8135	0.03536	0.3162	0.2848	CDC42/KIF5C/HSPA8/FGFR2/SNX1/RAB10/HSPA1B/HSPA1A/IL2RG/IST1/ARF1/ARPC3/EEA1/HLA-B/VPS36/EPN2/SNX2/IL2RA/CXCR4/NEDD4/ARPC5/WIPF3/KIF5A/WIPF1/VPS45/SNX6/CHMP4A/EPS15/STAM2/CAPZA1/SMURF1/ACTR2/SNX3/MDM2/PIP5K1A/RAB5B/BIN1/RUFY2/TRAF6/GRK6/HLA-E/STAMBP/RAB7A/EHD3/HLA-A/ACTR3B/HLA-F/PLD1/PDCD6IP/KIF5B/HSPA1L/SMAD3/RAB5C/VPS35/VTA1/RAB8A/RAB11A/SMAD2/CAPZB/AMPH	60
KEGG	hsa05320	Autoimmune thyroid disease	16/1562	53/8135	0.03634	0.3162	0.2848	TSHB/CGA/HLA-B/HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/HLA-A/HLA-F/IFNA1/HLA-DPB1/TPO/CD40/HLA-DQA1	16
KEGG	hsa04622	RIG-I-like receptor signaling pathway	20/1562	70/8135	0.03693	0.3162	0.2848	NFKBIA/DDX3X/DHX58/CYLD/NFKBIB/ATG12/NFKB1/CASP10/DDX58/RIPK1/NLRX1/MAPK8/IKBKB/TRAF6/RNF125/IRF3/TRADD/MAVS/IKBKE/IFNA1	20
KEGG	hsa04672	Intestinal immune network for IgA production	15/1562	49/8135	0.03726	0.3162	0.2848	ICOSLG/HLA-DOB/AICDA/CXCR4/HLA-DRA/ITGA4/HLA-DOA/HLA-DMB/HLA-DPA1/ITGB7/HLA-DPB1/MADCAM1/CCR9/CD40/HLA-DQA1	15
KEGG	hsa03440	Homologous recombination	13/1562	41/8135	0.03861	0.3162	0.2848	POLD3/BRCC3/PALB2/RAD54L/RPA2/RAD51D/POLD4/BRIP1/BARD1/RAD51C/XRCC2/MUS81/RAD54B	13
KEGG	hsa04932	Non-alcoholic fatty liver disease	39/1562	155/8135	0.03919	0.3162	0.2848	CDC42/DDIT3/SOCS3/ATF4/FOS/IRS2/UQCRFS1/UQCR10/SDHD/COX4I1/NDUFB3/BCL2L11/SDHA/NFKB1/AKT3/XBP1/NDUFA8/NDUFS2/NDUFB1/NDUFB5/INSR/CYC1/MAPK8/JUN/IKBKB/PIK3CD/SDHC/PIK3CA/COX7C/GSK3A/COX6B2/SDHB/IRS1/COX7A2L/NDUFA7/EIF2S1/NDUFA12/MAP3K5/ADIPOQ	39
KEGG	hsa04213	Longevity regulating pathway - multiple species	18/1562	62/8135	0.03988	0.3162	0.2848	IRS2/HSPA8/SOD2/HSPA1B/HSPA1A/AKT3/CAT/HDAC1/HDAC2/SOD1/INSR/PIK3CD/PIK3CA/PRKACB/IRS1/ADCY2/HSPA1L/FOXA2	18
KEGG	hsa03460	Fanconi anemia pathway	16/1562	54/8135	0.04276	0.3311	0.2983	UBE2T/POLH/RMI2/SLX1A/PALB2/HES1/RPA2/POLK/FANCF/BRIP1/FANCE/RAD51C/RMI1/MUS81/FANCC/WDR48	16
KEGG	hsa00340	Histidine metabolism	8/1562	22/8135	0.0452	0.3345	0.3013	ASPA/AMDHD1/MAOB/ALDH7A1/MAOA/CNDP2/ALDH3A2/ALDH1B1	8
KEGG	hsa00900	Terpenoid backbone biosynthesis	8/1562	22/8135	0.0452	0.3345	0.3013	PMVK/FDPS/GGPS1/RCE1/ZMPSTE24/ACAT1/IDI1/ICMT	8
KEGG	hsa05330	Allograft rejection	12/1562	38/8135	0.04725	0.3348	0.3016	HLA-B/HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/HLA-A/HLA-F/HLA-DPB1/CD40/HLA-DQA1	12
KEGG	hsa05340	Primary immunodeficiency	12/1562	38/8135	0.04725	0.3348	0.3016	PTPRC/UNG/IL2RG/AICDA/RFXAP/AIRE/DCLRE1C/BTK/TAP1/CD19/BLNK/CD40	12
KEGG	hsa05145	Toxoplasmosis	29/1562	112/8135	0.04925	0.3417	0.3078	NFKBIA/HSPA8/TGFB3/IL10RB/HSPA1B/HSPA1A/NFKBIB/NFKB1/AKT3/HLA-DOB/MAP2K6/PPIF/GNAI1/HLA-DRA/HLA-DOA/HLA-DMB/MAPK8/HLA-DPA1/IKBKB/TRAF6/MAPK1/BIRC3/IL10RA/LAMC3/HLA-DPB1/HSPA1L/CD40/LY96/HLA-DQA1	29
KEGG	hsa05210	Colorectal cancer	23/1562	86/8135	0.05383	0.3514	0.3165	CDKN1A/RAC2/PMAIP1/FOS/GADD45B/TGFB3/AREG/BBC3/BCL2L11/AKT3/MSH2/CCND1/POLK/CTNNB1/MAPK8/JUN/PIK3CD/PIK3CA/MAPK1/DCC/GRB2/SMAD3/SMAD2	23
KEGG	hsa00071	Fatty acid degradation	13/1562	43/8135	0.05527	0.3514	0.3165	ECI2/ADH6/ACADSB/ACADM/ALDH7A1/ACOX3/ACSL5/HADHB/ACAT1/HADH/ACSL6/ALDH3A2/ALDH1B1	13
KEGG	hsa04940	Type I diabetes mellitus	13/1562	43/8135	0.05527	0.3514	0.3165	HLA-B/HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/CPE/HLA-DPA1/HLA-E/HLA-A/HLA-F/PTPRN2/HLA-DPB1/HLA-DQA1	13
KEGG	hsa05416	Viral myocarditis	17/1562	60/8135	0.0555	0.3514	0.3165	RAC2/HLA-B/ACTG1/HLA-DOB/SGCA/HLA-DRA/CCND1/SGCB/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/HLA-A/HLA-F/HLA-DPB1/CD40/HLA-DQA1	17
KEGG	hsa04920	Adipocytokine signaling pathway	19/1562	69/8135	0.05798	0.3514	0.3165	NFKBIA/SOCS3/IRS2/NFKBIB/NFKBIE/NFKB1/AKT3/PCK2/MAPK8/IKBKB/RXRB/ACSL5/TRADD/PPARGC1A/IRS1/NPY/ACSL6/STK11/ADIPOQ	19
KEGG	hsa05211	Renal cell carcinoma	19/1562	69/8135	0.05798	0.3514	0.3165	HIF1A/CDKN1A/CDC42/TGFB3/EGLN2/FH/AKT3/ETS1/JUN/PIK3CD/PAK2/CRK/PIK3CA/MAPK1/EGLN3/ARNT/GRB2/PRCC/EP300	19
KEGG	hsa03060	Protein export	8/1562	23/8135	0.05803	0.3514	0.3165	HSPA5/SPCS2/IMMP1L/SEC61G/SPCS3/SEC61A2/SEC62/SRP9	8
KEGG	hsa04658	Th1 and Th2 cell differentiation	24/1562	92/8135	0.064	0.3745	0.3374	NFKBIA/FOS/IL2RG/NFKBIB/NFKBIE/NFKB1/IL2RA/HLA-DOB/STAT6/HLA-DRA/STAT5B/HLA-DOA/HLA-DMB/MAPK8/JUN/HLA-DPA1/IKBKB/NOTCH2/MAPK1/HLA-DPB1/NFATC2/RBPJ/TBX21/HLA-DQA1	24
KEGG	hsa04962	Vasopressin-regulated water reabsorption	13/1562	44/8135	0.06519	0.3745	0.3374	ARHGDIB/CREB3L4/ARHGDIA/DYNLL2/RAB5B/GNAS/DYNC1I2/PRKACB/DYNLL1/DYNC1I1/RAB5C/RAB11A/DCTN6	13
KEGG	hsa01200	Carbon metabolism	29/1562	115/8135	0.06635	0.3745	0.3374	HIBCH/SDHD/SDHA/MDH1/FH/CAT/PDHB/ALDOC/IDH1/ENO4/SHMT2/ACSS1/SUCLG2/DLAT/SDHC/PRPS2/ACOX3/PDHA1/GOT2/PFKL/PGAM2/MCEE/ACAT1/SDHB/SUCLG1/PHGDH/DLST/ALDOB/RPE	29
KEGG	hsa04666	Fc gamma R-mediated phagocytosis	25/1562	97/8135	0.06746	0.3745	0.3374	RAC2/CDC42/PTPRC/ARPC3/AKT3/ARPC5/INPP5D/ACTR2/PLCG2/NCF1/PIP5K1A/BIN1/SPHK2/PIK3CD/CRK/PIK3CA/MAPK1/FCGR2B/PLA2G4C/ACTR3B/PLD1/LYN/VAV2/PRKCD/AMPH	25
KEGG	hsa05033	Nicotine addiction	12/1562	40/8135	0.06747	0.3745	0.3374	GABRG2/CACNA1B/GABRB3/CACNA1A/GABRB2/GRIA3/SLC17A8/CHRNA7/GRIA2/GABRA4/GABRA5/CHRNA6	12
KEGG	hsa01240	Biosynthesis of cofactors	37/1562	153/8135	0.07283	0.3976	0.3582	NMNAT1/MAT2B/NQO1/SDR16C5/OXSM/COQ2/COQ5/MOCS2/ALAS1/SHMT2/FLAD1/RDH13/PTS/PPOX/UGT2B7/UGDH/MTHFD1L/BCAT2/HPD/KYNU/EARS2/COX15/AK2/AFMID/CPOX/ALPP/COASY/NMNAT2/PPCS/LIPT1/GCLM/CAD/ALDH3A2/UGT2B10/LIAS/HMBS/ALDH1B1	37
KEGG	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	23/1562	89/8135	0.07513	0.4031	0.3631	NFKBIA/HIF1A/PTPN6/FOS/CSNK2A1/NFKBIB/NFKBIE/TLR9/NFKB1/AKT3/MAP2K6/JUN/IKBKB/PIK3CD/TRAF6/PIK3CA/MAPK1/BATF/BATF2/CSNK2A3/PTEN/NFATC2/TICAM2	23
KEGG	hsa00010	Glycolysis / Gluconeogenesis	18/1562	67/8135	0.07834	0.4031	0.3631	LDHB/PDHB/GAPDHS/ALDOC/ADH6/ENO4/PCK2/ACSS1/DLAT/ALDH7A1/PDHA1/PFKL/PGAM2/BPGM/ALDH3A2/ALDOB/MINPP1/ALDH1B1	18
KEGG	hsa05212	Pancreatic cancer	20/1562	76/8135	0.07921	0.4031	0.3631	CDKN1A/RAC2/CDC42/GADD45B/TGFB3/NFKB1/AKT3/CCND1/RALBP1/POLK/MAPK8/IKBKB/PIK3CD/PIK3CA/MAPK1/ERBB2/CDK4/PLD1/SMAD3/SMAD2	20
KEGG	hsa04216	Ferroptosis	12/1562	41/8135	0.07942	0.4031	0.3631	PRNP/SLC3A2/VDAC3/VDAC2/SAT1/FTH1/MAP1LC3B/ACSL5/GCLM/ATG7/ACSL6/LPCAT3	12
KEGG	hsa05020	Prion disease	62/1562	273/8135	0.07989	0.4031	0.3631	PSMA8/PRNP/HSPA5/RAC2/DDIT3/KIF5C/ATF4/HSPA8/UQCRFS1/CREB3L4/TUBB2A/UQCR10/VDAC3/HSPA1B/HSPA1A/SDHD/COX4I1/VDAC2/CACNA1B/CSNK2A1/NDUFB3/CYBA/NCAM2/TUBB4A/SDHA/TUBB2B/KIF5A/NDUFA8/NDUFS2/PPIF/NDUFB1/PSMD4/TUBB4B/SOD1/NDUFB5/NCF1/CACNA1C/CYC1/MAPK8/PIK3CD/PSMA7/SDHC/PSMC2/PIK3CA/NCF4/MAPK1/PRKACB/PSMB2/COX7C/CASP12/CSNK2A3/COX6B2/SDHB/KIF5B/PSMA3/HSPA1L/COX7A2L/NDUFA7/PRKCD/EIF2S1/NDUFA12/PSMD7	62
KEGG	hsa00310	Lysine degradation	17/1562	63/8135	0.08254	0.4042	0.3642	SUV39H2/EZH2/PRDM2/MECOM/SETD7/TMLHE/ALDH7A1/EZH1/ACAT1/HADH/SETDB2/DLST/SETD1A/PHYKPL/ALDH3A2/ALDH1B1/PIPOX	17
KEGG	hsa04623	Cytosolic DNA-sensing pathway	17/1562	63/8135	0.08254	0.4042	0.3642	NFKBIA/POLR3D/NFKBIB/NFKB1/POLR3GL/POLR3B/DDX58/POLR3K/RIPK1/IKBKB/AIM2/IRF3/CASP1/MAVS/IKBKE/IFNA1/POLR2F	17
KEGG	hsa05110	Vibrio cholerae infection	14/1562	50/8135	0.08426	0.4058	0.3656	ATP6V0E1/ATP6V1B1/ATP6V1D/ARF1/ACTG1/PLCG2/ATP6V1G3/GNAS/ATP6V1G1/SEC61G/ATP6V1F/PRKACB/ATP6V1A/SEC61A2	14
KEGG	hsa04130	SNARE interactions in vesicular transport	10/1562	33/8135	0.08545	0.4058	0.3656	BNIP1/VAMP8/STX7/VAMP1/VTI1A/SEC22B/VTI1B/BET1/SNAP23/STX17	10
KEGG	hsa04010	MAPK signaling pathway	66/1562	294/8135	0.08792	0.4058	0.3656	DUSP5/RAC2/DUSP1/CDC42/DDIT3/ATF4/FOS/HSPA8/GADD45B/FGFR2/MAP3K8/TGFB3/ERBB4/AREG/DAXX/DUSP2/HSPA1B/HSPA1A/CACNA1B/EFNA3/ANGPT1/CACNA1A/MKNK2/CACNG2/MAPT/NFKB1/AKT3/MAP2K6/JUND/MECOM/CACNG8/DUSP10/DUSP8/CACNA1C/EFNA4/LAMTOR3/INSR/MAPK8/CACNA1G/JUN/IKBKB/RELB/PAK2/CRK/NR4A1/TRAF6/NLK/RPS6KA1/MAPK1/PRKACB/ERBB2/DUSP4/TRADD/GNA12/CACNA2D2/PLA2G4C/RASGRP2/GRB2/FGF16/HSPA1L/NF1/SRF/TEK/MAP4K4/ELK4/MAP3K5	66
KEGG	hsa05140	Leishmaniasis	20/1562	77/8135	0.08852	0.4058	0.3656	NFKBIA/PTPN6/FOS/TGFB3/NFKBIB/CYBA/NFKB1/HLA-DOB/HLA-DRA/NCF1/ITGA4/HLA-DOA/HLA-DMB/JUN/HLA-DPA1/TRAF6/NCF4/MAPK1/HLA-DPB1/HLA-DQA1	20
KEGG	hsa05135	Yersinia infection	33/1562	137/8135	0.09018	0.4058	0.3656	NFKBIA/RAC2/CDC42/FOS/ARHGEF28/ARPC3/ACTG1/NFKB1/AKT3/MAP2K6/ARPC5/PTK2B/WIPF3/WIPF1/ACTR2/RHOG/PIP5K1A/ITGA4/MAPK8/JUN/IKBKB/PIK3CD/CRK/TRAF6/PIK3CA/IRF3/RPS6KA1/MAPK1/ROCK2/CASP1/ACTR3B/NFATC2/VAV2	33
KEGG	hsa00770	Pantothenate and CoA biosynthesis	7/1562	21/8135	0.09085	0.4058	0.3656	ENPP1/VNN2/BCAT2/COASY/PPCS/ALDH3A2/ALDH1B1	7
KEGG	hsa00380	Tryptophan metabolism	12/1562	42/8135	0.09262	0.4058	0.3656	CAT/ACMSD/MAOB/ALDH7A1/KYNU/AFMID/MAOA/ACAT1/HADH/DLST/ALDH3A2/ALDH1B1	12
KEGG	hsa05332	Graft-versus-host disease	12/1562	42/8135	0.09262	0.4058	0.3656	HLA-B/HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/HLA-A/HLA-F/HLA-DPB1/KIR3DL3/HLA-DQA1	12
KEGG	hsa04722	Neurotrophin signaling pathway	29/1562	119/8135	0.09509	0.4112	0.3705	NFKBIA/CDC42/ATF4/CALM2/ARHGDIB/NFKBIB/SH2B3/NFKBIE/NFKB1/AKT3/ARHGDIA/PLCG2/RIPK2/SHC3/SH2B2/TP73/MAPK8/JUN/IKBKB/PIK3CD/CRK/TRAF6/PIK3CA/RPS6KA1/MAPK1/GRB2/IRS1/PRKCD/MAP3K5	29
KEGG	hsa05164	Influenza A	40/1562	171/8135	0.09745	0.416	0.3748	NFKBIA/NXT1/SOCS3/OAS1/OAS2/NFKBIB/TNFSF10/ACTG1/NFKB1/AKT3/HLA-DOB/FDPS/HLA-DRA/DDX58/MX1/NLRX1/HLA-DOA/HLA-DMB/HLA-DPA1/IKBKB/PIK3CD/TMPRSS2/RNASEL/PIK3CA/IRF3/MAPK1/CASP1/CDK4/TRADD/CCND3/MAVS/IKBKE/IFNA1/HLA-DPB1/RAB11A/MX2/EIF2S1/STAT2/EP300/HLA-DQA1	40
KEGG	hsa05417	Lipid and atherosclerosis	49/1562	215/8135	0.1043	0.4331	0.3902	NFKBIA/HSPA5/CDC42/DDIT3/ATF4/FOS/CALM2/HSPA8/SOD2/HSPA1B/HSPA1A/CYBA/TNFSF10/NFKB1/AKT3/MAP2K6/XBP1/POU2F2/CYP2C9/NCF1/MAPK8/JUN/IKBKB/PIK3CD/RXRB/TRAF6/PIK3CA/IRF3/NCF4/MAPK1/ROCK2/CASP1/HSP90B1/IKBKE/CYP2A7/IFNA1/ABCA1/LYN/HSP90AB1/HSPA1L/NFATC2/TICAM2/VAV2/CD40/LY96/HSP90AA1/EIF2S1/CASP6/MAP3K5	49
KEGG	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1562	30/8135	0.1053	0.4331	0.3902	MDH1/CAT/SHMT2/ACSS1/AFMID/MCEE/GRHPR/ACAT1/GLUL	9
KEGG	hsa03015	mRNA surveillance pathway	24/1562	97/8135	0.1054	0.4331	0.3902	NXT1/ETF1/PPP2CA/DDX19B/CSTF3/RNMT/PPP2R2B/PABPC4/PPP2R1A/PABPC1/PPP2R3B/PAPOLA/UPF3B/EIF4A3/RNGTT/CPSF2/ALYREF/PPP1CA/PABPC3/RBM8A/PAPOLG/SRRM1/CPSF3/MSI1	24
KEGG	hsa00220	Arginine biosynthesis	7/1562	22/8135	0.1122	0.4554	0.4103	GLS2/NAGS/GLS/GOT2/ASS1/GLUL/ARG2	7
KEGG	hsa01230	Biosynthesis of amino acids	19/1562	75/8135	0.1157	0.4572	0.4119	MAT2B/NAGS/ALDOC/IDH1/ENO4/SHMT2/ALDH18A1/PRPS2/BCAT2/GOT2/PFKL/ASS1/PGAM2/PYCR2/GLUL/PHGDH/ALDOB/RPE/ARG2	19
KEGG	hsa04530	Tight junction	39/1562	169/8135	0.1176	0.4572	0.4119	CDC42/WHAMM/PPP2CA/YBX3/MYL12A/PPP2R2B/ARPC3/ACTG1/MYH10/NEDD4/PPP2R1A/ARPC5/CLDN11/ARHGEF2/HCLS1/MYL12B/CCND1/ACTR2/CGN/ARHGAP17/NF2/MAPK8/JUN/AMOTL1/AMOT/CLDN19/PRKACB/ROCK2/ERBB2/CDK4/CLDN7/PCNA/ACTR3B/MYH11/TJAP1/MAGI1/RAB8A/STK11/MAP3K5	39
KEGG	hsa05202	Transcriptional misregulation in cancer	44/1562	193/8135	0.118	0.4572	0.4119	CDKN1A/DDIT3/GADD45B/NFKB1/BCL6/BMI1/HDAC1/KDM6A/HDAC2/FLI1/MDM2/POLK/GRIA3/BMP2K/PAX5/TMPRSS2/RXRB/RARA/CDK14/MEN1/BIRC3/WNT16/WT1/LYL1/ITGB7/NR4A3/FUT8/SPINT1/ATF1/IGFBP3/NFKBIZ/SIN3A/PRCC/ETV7/JMJD1C/CD40/PAX7/HHEX/ETV4/ELK4/PBX1/SIX1/CCNA2/EWSR1	44
KEGG	hsa04211	Longevity regulating pathway	22/1562	89/8135	0.1181	0.4572	0.4119	ATF4/IRS2/SOD2/CREB3L4/RHEB/NFKB1/AKT3/CAT/RB1CC1/ATG13/INSR/PIK3CD/PIK3CA/PRKACB/ULK1/TSC1/PPARGC1A/SESN3/IRS1/ADCY2/STK11/ADIPOQ	22
KEGG	hsa04064	NF-kappa B signaling pathway	25/1562	104/8135	0.1293	0.4872	0.4389	NFKBIA/TNFAIP3/GADD45B/LTB/CYLD/CSNK2A1/NFKB1/DDX58/PLCG2/RIPK1/EDA2R/IKBKB/RELB/PARP1/TRAF6/BIRC3/TRAF5/TRADD/BTK/CSNK2A3/LYN/TICAM2/BLNK/CD40/LY96	25
KEGG	hsa05165	Human papillomavirus infection	72/1562	331/8135	0.1295	0.4872	0.4389	CDKN1A/CDC42/PPP2CA/PTGER4/ATP6V0E1/CREB3L4/ATP6V1B1/ATP6V1D/RHEB/PPP2R2B/HLA-B/ITGA3/NFKB1/AKT3/PPP2R1A/PPP2R3B/COL6A5/HDAC1/CCND1/HDAC2/HES1/MX1/TUBG2/MDM2/NOTCH4/CTNNB1/WNT11/WNT3/ITGA4/ITGA1/ATP6V1G3/IKBKB/PIK3CD/ITGA10/GNAS/ATP6V1G1/PIK3CA/NOTCH2/HLA-E/IRF3/ATP6V1F/MAPK1/WNT16/PRKACB/MFNG/TUBG1/CDK4/ITGA8/ATP6V1A/ITGB7/HLA-A/TRADD/CCND3/IRF1/TSC1/IKBKE/HLA-F/LAMC3/COL9A1/PTEN/WNT6/GRB2/IFNA1/MAGI1/FZD3/RBPJ/MX2/ITGB6/STAT2/EP300/CCNA2/HES2	72
KEGG	hsa04966	Collecting duct acid secretion	8/1562	27/8135	0.1302	0.4872	0.4389	ATP6V0E1/ATP6V1B1/ATP6V1D/ATP6V1G3/ATP6V1G1/ATP6V1F/ATP6V1A/CA2	8
KEGG	hsa05030	Cocaine addiction	13/1562	49/8135	0.1317	0.4873	0.439	ATF4/CREB3L4/NFKB1/GNAI1/GRM3/JUN/MAOB/FOSB/GNAS/DLG4/PRKACB/GRIA2/MAOA	13
KEGG	hsa05223	Non-small cell lung cancer	18/1562	72/8135	0.1356	0.4929	0.4441	CDKN1A/KIF5C/GADD45B/AKT3/KIF5A/RASSF1/CCND1/STAT5B/PLCG2/POLK/PIK3CD/RXRB/PIK3CA/MAPK1/ERBB2/CDK4/GRB2/KIF5B	18
KEGG	hsa05022	Pathways of neurodegeneration - multiple diseases	101/1562	476/8135	0.1379	0.4929	0.4441	PSMA8/PRNP/HSPA5/UBC/DDIT3/KIF5C/ATF4/CALM2/UQCRFS1/DAXX/TUBB2A/UQCR10/ATG2A/VDAC3/SDHD/COX4I1/VDAC2/CACNA1B/CSNK2A1/NDUFB3/CAPN1/NEFL/TUBB4A/SDHA/DNAI2/MAPT/DNAL4/NFKB1/TUBB2B/ATXN1L/MAP2K6/XBP1/KIF5A/CAT/C9orf72/NDUFA8/RB1CC1/NDUFS2/PPIF/DNAH5/NDUFB1/ATG13/ATXN2/PSMD4/TUBB4B/SOD1/NDUFB5/MAP1LC3B/UBE2J2/RAB39B/SQSTM1/CACNA1C/CTNNB1/WNT11/WNT3/RAB1A/GRIA3/CYC1/MAPK8/CHRM3/HTRA2/PSMA7/SDHC/PSMC2/FRAT1/DLG4/MAPK1/WNT16/PSMB2/VAPB/COX7C/ULK1/DNAL1/NEFH/CASP12/CSNK2A3/CHRNA7/DNAH2/DNAH10/CCS/DNAH9/GRIA2/NEFM/COX6B2/WNT6/SDHB/KIF5B/PSMA3/ATXN3/FZD3/DKK4/COX7A2L/NDUFA7/RAB8A/DNAH6/DCTN6/DNAH3/EIF2S1/NDUFA12/MAP3K5/PSMD7	101
KEGG	hsa04071	Sphingolipid signaling pathway	28/1562	119/8135	0.1385	0.4929	0.4441	RAC2/GNA13/S1PR2/PPP2CA/PPP2R2B/S1PR4/NFKB1/AKT3/PPP2R1A/PPP2R3B/GNAI1/SGPP1/CERS6/MAPK8/SPHK2/PIK3CD/PIK3CA/MAPK1/ROCK2/KNG1/TRADD/CERS4/GNA12/PTEN/PLD1/NSMAF/SMPD2/MAP3K5	28
KEGG	hsa05161	Hepatitis B	37/1562	162/8135	0.1391	0.4929	0.4441	NFKBIA/CDKN1A/ATF4/FOS/TGFB3/DDX3X/CREB3L4/VDAC3/NFKB1/AKT3/MAP2K6/PTK2B/CASP10/STAT6/STAT5B/DDX58/MAPK8/JUN/IKBKB/PIK3CD/TRAF6/PIK3CA/IRF3/MAPK1/MAVS/CASP12/IKBKE/PCNA/GRB2/IFNA1/SMAD3/NFATC2/TICAM2/DDB1/STAT2/EP300/CCNA2	37
KEGG	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1562	11/8135	0.1438	0.5039	0.454	NQO1/COQ2/COQ5/HPD	4
KEGG	hsa00562	Inositol phosphate metabolism	18/1562	73/8135	0.1494	0.513	0.4621	PI4K2A/MTMR6/PIP4K2A/PIK3C2G/SACM1L/INPP5D/PLCG2/INPP4B/PIP5K1A/PI4K2B/PIK3CD/INPP5F/PIK3CA/MTMR4/PLCE1/PTEN/PI4KB/MINPP1	18
KEGG	hsa01524	Platinum drug resistance	18/1562	73/8135	0.1494	0.513	0.4621	CDKN1A/PMAIP1/POLH/BBC3/AKT3/XPA/MSH2/GSTM5/MDM2/GSTT1/PIK3CD/PIK3CA/MAPK1/BIRC3/ERBB2/GSTA1/GSTM4/MAP3K5	18
KEGG	hsa05207	Chemical carcinogenesis - receptor activation	47/1562	212/8135	0.1531	0.5201	0.4685	ATF4/FOS/CREB3L4/CACNA1B/CACNA1A/PAQR7/NFKB1/PAQR8/AKT3/BCL6/GSTM5/GNAI1/CCND1/STAT5B/MIRLET7D/CACNA1C/GSTT1/JUN/PIK3CD/GNAS/RXRB/UGT2B7/PTGES3/PIK3CA/NOTCH2/RPS6KA1/ESR1/AHR/MAPK1/PRKACB/AIP/HSP90B1/CHRNA9/CCND3/EPHX2/ARNT/CHRNA7/IKBKE/GRB2/ADCY2/HSP90AB1/FGF16/NR1I3/GSTA1/GSTM4/HSP90AA1/UGT2B10	47
KEGG	hsa05012	Parkinson disease	58/1562	266/8135	0.1546	0.5201	0.4685	PSMA8/HSPA5/UBC/DUSP1/DDIT3/KIF5C/ATF4/CALM2/UQCRFS1/DAXX/TUBB2A/UQCR10/VDAC3/SDHD/COX4I1/VDAC2/SLC39A10/NDUFB3/TUBB4A/SDHA/MAPT/TUBB2B/XBP1/KIF5A/NDUFA8/NDUFS2/PPIF/NDUFB1/GNAI1/PSMD4/TUBB4B/SOD1/NDUFB5/UBE2J2/CYC1/MAPK8/KEAP1/MAOB/HTRA2/PSMA7/SDHC/PSMC2/GNAS/PRKACB/PSMB2/COX7C/MAOA/COX6B2/SDHB/SLC39A1/KIF5B/PSMA3/COX7A2L/NDUFA7/EIF2S1/NDUFA12/MAP3K5/PSMD7	58
KEGG	hsa05215	Prostate cancer	23/1562	97/8135	0.1573	0.5237	0.4718	NFKBIA/CDKN1A/ATF4/FGFR2/CREB3L4/NFKB1/AKT3/CCND1/MDM2/CTNNB1/IKBKB/PIK3CD/TMPRSS2/PIK3CA/MAPK1/ERBB2/HSP90B1/SPINT1/PTEN/GRB2/HSP90AB1/HSP90AA1/EP300	23
KEGG	hsa05016	Huntington disease	66/1562	306/8135	0.1591	0.5245	0.4725	PSMA8/KIF5C/UQCRFS1/SOD2/BBC3/CREB3L4/TUBB2A/UQCR10/ATG2A/VDAC3/SDHD/COX4I1/VDAC2/CACNA1B/NDUFB3/TUBB4A/SDHA/DNAI2/DNAL4/TUBB2B/KIF5A/NDUFA8/RB1CC1/NDUFS2/PPIF/DNAH5/NDUFB1/ATG13/HDAC1/PSMD4/TUBB4B/HDAC2/SOD1/NDUFB5/GRIA3/CYC1/MAPK8/PSMA7/SDHC/PSMC2/DLG4/PSMB2/COX7C/ULK1/DNAL1/PPARGC1A/DNAH2/DNAH10/DNAH9/GRIA2/POLR2A/COX6B2/SDHB/SIN3A/KIF5B/PSMA3/POLR2F/COX7A2L/NDUFA7/DNAH6/DCTN6/DNAH3/NDUFA12/EP300/MAP3K5/PSMD7	66
KEGG	hsa04923	Regulation of lipolysis in adipocytes	14/1562	56/8135	0.1734	0.5537	0.4988	IRS2/TSHB/CGA/LIPE/AKT3/GNAI1/INSR/PIK3CD/GNAS/PIK3CA/PRKACB/IRS1/ADCY2/NPY	14
KEGG	hsa04917	Prolactin signaling pathway	17/1562	70/8135	0.1743	0.5537	0.4988	SOCS3/FOS/CGA/NFKB1/AKT3/ELF5/LHB/CCND1/STAT5B/SHC3/MAPK8/PIK3CD/PIK3CA/ESR1/MAPK1/IRF1/GRB2	17
KEGG	hsa05230	Central carbon metabolism in cancer	17/1562	70/8135	0.1743	0.5537	0.4988	HIF1A/FGFR2/LDHB/GLS2/AKT3/SLC7A5/PDHB/IDH1/PIK3CD/GLS/PIK3CA/MAPK1/PDHA1/ERBB2/PFKL/PGAM2/PTEN	17
KEGG	hsa04150	mTOR signaling pathway	35/1562	156/8135	0.1746	0.5537	0.4988	SLC3A2/ATP6V1B1/ATP6V1D/RHEB/AKT3/SLC7A5/SLC38A9/LPIN3/WNT11/WNT3/LAMTOR3/INSR/ATP6V1G3/IKBKB/PIK3CD/DDIT4/ATP6V1G1/PIK3CA/RPS6KA1/ATP6V1F/MAPK1/WNT16/ATP6V1A/NPRL2/ULK1/SGK1/TSC1/DEPDC5/TTI1/PTEN/WNT6/GRB2/IRS1/FZD3/STK11	35
KEGG	hsa04392	Hippo signaling pathway - multiple species	8/1562	29/8135	0.1781	0.5596	0.5042	LIMD1/WTIP/MOB1A/RASSF1/FRMD6/NF2/TEAD4/SAV1	8
KEGG	hsa05160	Hepatitis C	35/1562	157/8135	0.1853	0.5766	0.5195	NFKBIA/CDKN1A/SOCS3/PPP2CA/OAS1/OAS2/PPP2R2B/NFKB1/AKT3/PPP2R1A/CLDN11/CCND1/DDX58/MX1/RIPK1/CTNNB1/IKBKB/PIK3CD/RNASEL/TRAF6/PIK3CA/CD81/IRF3/MAPK1/CLDN19/CDK4/TRADD/MAVS/CLDN7/IKBKE/GRB2/IFNA1/MX2/EIF2S1/STAT2	35
KEGG	hsa01212	Fatty acid metabolism	14/1562	57/8135	0.1916	0.5909	0.5324	HSD17B4/OXSM/ACADSB/HSD17B12/ELOVL1/ACADM/ELOVL5/ACOX3/ACSL5/TECR/HADHB/ACAT1/HADH/ACSL6	14
KEGG	hsa05418	Fluid shear stress and atherosclerosis	31/1562	139/8135	0.202	0.617	0.5558	RAC2/DUSP1/FOS/CALM2/KLF2/CYBA/NQO1/ACTG1/NFKB1/AKT3/MAP2K6/ARHGEF2/GSTM5/SUMO2/SQSTM1/NCF1/CTNNB1/GSTT1/MAPK8/KEAP1/JUN/IKBKB/PIK3CD/PIK3CA/HSP90B1/ASS1/HSP90AB1/GSTA1/GSTM4/HSP90AA1/MAP3K5	31
KEGG	hsa04152	AMPK signaling pathway	27/1562	120/8135	0.2073	0.6275	0.5653	IRS2/RAB10/PPP2CA/CREB3L4/RHEB/PPP2R2B/MLYCD/LIPE/AKT3/PPP2R1A/PPP2R3B/CCND1/ELAVL1/PCK2/INSR/PIK3CD/ADRA1A/PIK3CA/PFKL/ULK1/TSC1/PPARGC1A/IRS1/RAB8A/STK11/ADIPOQ/CCNA2	27
KEGG	hsa04919	Thyroid hormone signaling pathway	27/1562	121/8135	0.2208	0.6507	0.5863	HIF1A/RHEB/ACTG1/AKT3/HDAC1/MED12/MED16/CCND1/HDAC2/PLCG2/ATP1A1/MDM2/NOTCH4/CTNNB1/PIK3CD/RXRB/PIK3CA/NOTCH2/ESR1/MAPK1/PRKACB/PFKL/PLCE1/MED13L/SIN3A/RCAN2/EP300	27
KEGG	hsa00830	Retinol metabolism	16/1562	68/8135	0.221	0.6507	0.5863	DHRS9/SDR16C5/CYP3A5/RPE65/ADH6/CYP2C9/RDH5/RDH13/RDH16/DHRS4L2/UGT2B7/CYP27C1/CYP2A7/DHRS4/ALDH1A3/UGT2B10	16
KEGG	hsa04110	Cell cycle	28/1562	126/8135	0.2225	0.6507	0.5863	CDKN1A/GADD45B/TGFB3/ANAPC16/DBF4/CHEK2/MCM3/ANAPC15/SMC1B/ORC5/HDAC1/CCND1/HDAC2/WEE1/MDM2/CDC26/CDK4/CCND3/WEE2/PCNA/ANAPC7/CDC45/CDC23/SMAD3/SMC1A/SMAD2/EP300/CCNA2	28
KEGG	hsa04070	Phosphatidylinositol signaling system	22/1562	97/8135	0.2245	0.6507	0.5863	CALM2/PI4K2A/MTMR6/DGKH/PIP4K2A/PIK3C2G/SACM1L/DGKG/INPP5D/PLCG2/INPP4B/PIP5K1A/PI4K2B/DGKB/PIK3CD/INPP5F/PIK3CA/MTMR4/PLCE1/PTEN/PPIP5K1/PI4KB	22
KEGG	hsa04115	p53 signaling pathway	17/1562	73/8135	0.2252	0.6507	0.5863	CDKN1A/SIVA1/PMAIP1/GADD45B/CHEK2/BBC3/CD82/CCND1/MDM2/TP73/CDK4/CCND3/SESN3/IGFBP3/PTEN/RRM2B/AIFM2	17
KEGG	hsa03450	Non-homologous end-joining	4/1562	13/8135	0.2284	0.6507	0.5863	DCLRE1C/XRCC5/LIG4/POLL	4
KEGG	hsa04218	Cellular senescence	34/1562	156/8135	0.2304	0.6507	0.5863	CDKN1A/CALM2/GADD45B/TGFB3/CHEK2/VDAC3/VDAC2/RHEB/CAPN1/HLA-B/NFKB1/AKT3/ETS1/MAP2K6/CCND1/MDM2/SQSTM1/PIK3CD/PIK3CA/HLA-E/MAPK1/CDK4/HLA-A/CCND3/LIN37/TSC1/PPP1CA/IGFBP3/HLA-F/PTEN/SMAD3/NFATC2/SMAD2/CCNA2	34
KEGG	hsa04668	TNF signaling pathway	25/1562	112/8135	0.2312	0.6507	0.5863	NFKBIA/TNFAIP3/JUNB/SOCS3/ATF4/FOS/BCL3/MAP3K8/CREB3L4/NFKB1/AKT3/MAP2K6/CASP10/RIPK1/MAPK8/JUN/IKBKB/PIK3CD/PIK3CA/MAPK1/BIRC3/TRAF5/TRADD/IRF1/MAP3K5	25
KEGG	hsa05310	Asthma	8/1562	31/8135	0.2325	0.6507	0.5863	HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-DPB1/CD40/HLA-DQA1	8
KEGG	hsa05323	Rheumatoid arthritis	21/1562	93/8135	0.2378	0.658	0.5928	FOS/TGFB3/ATP6V0E1/ATP6V1B1/LTB/ATP6V1D/ANGPT1/HLA-DOB/ACP5/HLA-DRA/HLA-DOA/HLA-DMB/ATP6V1G3/JUN/HLA-DPA1/ATP6V1G1/ATP6V1F/ATP6V1A/HLA-DPB1/TEK/HLA-DQA1	21
KEGG	hsa05031	Amphetamine addiction	16/1562	69/8135	0.2397	0.658	0.5928	ATF4/FOS/CALM2/CREB3L4/HDAC1/HDAC2/CACNA1C/GRIA3/JUN/MAOB/FOSB/GNAS/PRKACB/PPP1CA/GRIA2/MAOA	16
KEGG	hsa03040	Spliceosome	32/1562	147/8135	0.2411	0.658	0.5928	HSPA8/HSPA1B/HSPA1A/SRSF3/SNRPB/SRSF1/TRA2B/BUD31/WBP11/SNRPD3/SRSF6/THOC3/SNRPA1/EIF4A3/LSM6/CTNNBL1/SNRPF/SF3A3/LSM2/ALYREF/PLRG1/RBM8A/SF3B3/HNRNPM/TRA2A/HNRNPA1/HSPA1L/LSM5/PRPF38A/TCERG1/SF3B1/HNRNPA1L2	32
KEGG	hsa04657	IL-17 signaling pathway	21/1562	94/8135	0.2544	0.6583	0.593	NFKBIA/TNFAIP3/FOS/TRAF4/SRSF1/NFKB1/CCL17/JUND/ELAVL1/MAPK8/JUN/IKBKB/FOSB/TRAF6/MAPK1/TRAF5/TRADD/HSP90B1/IKBKE/HSP90AB1/HSP90AA1	21
KEGG	hsa05321	Inflammatory bowel disease	15/1562	65/8135	0.2555	0.6583	0.593	TGFB3/IL2RG/NFKB1/HLA-DOB/STAT6/HLA-DRA/HLA-DOA/HLA-DMB/JUN/HLA-DPA1/HLA-DPB1/SMAD3/TBX21/SMAD2/HLA-DQA1	15
KEGG	hsa03050	Proteasome	11/1562	46/8135	0.2582	0.6583	0.593	PSMA8/PSMB9/PSMB8/POMP/PSMD4/PSMB10/PSMA7/PSMC2/PSMB2/PSMA3/PSMD7	11
KEGG	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1562	70/8135	0.2591	0.6583	0.593	NFKBIA/CDC42/ATP6V0E1/ATP6V1B1/ATP6V1D/NFKB1/PLCG2/MAPK8/ATP6V1G3/JUN/IKBKB/ATP6V1G1/ATP6V1F/ATP6V1A/LYN/ADAM10	16
KEGG	hsa05415	Diabetic cardiomyopathy	43/1562	203/8135	0.2592	0.6583	0.593	RAC2/UQCRFS1/TGFB3/UQCR10/VDAC3/SDHD/COX4I1/VDAC2/NDUFB3/CYBA/SDHA/NFKB1/AKT3/NDUFA8/NDUFS2/PPIF/NDUFB1/PDHB/NDUFB5/NCF1/INSR/CYC1/MAPK8/PIK3CD/SDHC/PARP1/MPC1/PIK3CA/NCF4/PDHA1/COX7C/PPP1CA/PTEN/COX6B2/SDHB/IRS1/SMAD3/COX7A2L/NDUFA7/PRKCD/SMAD2/NDUFA12/GSR	43
KEGG	hsa04810	Regulation of actin cytoskeleton	46/1562	218/8135	0.2595	0.6583	0.593	RAC2/GNA13/CDC42/LPAR5/FGFR2/MYL12A/IQGAP1/ARPC3/ACTG1/PIP4K2A/ITGA3/MYH10/FGD1/CXCR4/FGD3/PPP1R12A/ARPC5/ENAH/MYL12B/ACTR2/PIP5K1A/ITGA4/ITGA1/PIK3CD/CHRM3/ITGA10/PAK2/CRK/PIK3CA/MAPK1/ROCK2/BRK1/ITGA8/ABI2/KNG1/ITGB7/LPAR4/GNA12/PPP1CA/ACTR3B/MYH11/FGF16/VAV2/ITGB6/ARHGEF4/MYL7	46
KEGG	hsa04066	HIF-1 signaling pathway	24/1562	109/8135	0.2598	0.6583	0.593	HIF1A/CDKN1A/EGLN2/LDHB/ANGPT1/MKNK2/NFKB1/AKT3/PDHB/ALDOC/ENO4/PLCG2/INSR/PIK3CD/PIK3CA/MAPK1/PDHA1/ERBB2/PFKL/EGLN3/ARNT/TEK/ALDOB/EP300	24
KEGG	hsa04670	Leukocyte transendothelial migration	25/1562	114/8135	0.2612	0.6583	0.593	RAC2/CDC42/MYL12A/CYBA/RAPGEF3/ACTG1/CXCR4/PTK2B/CLDN11/GNAI1/MYL12B/TXK/PLCG2/NCF1/CTNNB1/ITGA4/PIK3CD/PIK3CA/NCF4/CLDN19/ROCK2/SIPA1/CLDN7/VAV2/MYL7	25
KEGG	hsa03320	PPAR signaling pathway	17/1562	75/8135	0.2623	0.6583	0.593	UBC/SLC27A4/FABP3/PLIN2/LPL/SLC27A6/PLTP/FABP2/PCK2/ACADM/RXRB/DBI/ACOX3/ACSL5/ACSL6/APOA5/ADIPOQ	17
KEGG	hsa04935	Growth hormone synthesis, secretion and action	26/1562	119/8135	0.2625	0.6583	0.593	JUNB/SOCS3/ATF4/FOS/IRS2/CREB3L4/AKT3/MAP2K6/GNAI1/STAT5B/PLCG2/SHC3/CACNA1C/MAPK8/PIK3CD/CRK/GNAS/PIK3CA/MAPK1/PRKACB/IGFBP3/GRB2/IRS1/ADCY2/SSTR2/EP300	26
KEGG	hsa04012	ErbB signaling pathway	19/1562	85/8135	0.2674	0.6583	0.593	CDKN1A/ERBB4/AREG/AKT3/NRG3/STAT5B/PLCG2/SHC3/MAPK8/JUN/PIK3CD/PAK2/CRK/PIK3CA/MAPK1/ERBB2/NRG4/GRB2/BTC	19
KEGG	hsa04514	Cell adhesion molecules	32/1562	149/8135	0.2677	0.6583	0.593	SELL/NLGN4X/PTPRC/NCAM2/ICOSLG/HLA-B/HLA-DOB/CLDN11/ICAM2/CNTNAP2/LRRC4C/HLA-DRA/ITGA4/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-E/NTNG1/CLDN19/ITGA8/ITGB7/HLA-A/CLDN7/HLA-F/HLA-DPB1/CADM3/ALCAM/MADCAM1/CD40/MPZL1/NLGN4Y/HLA-DQA1	32
KEGG	hsa00250	Alanine, aspartate and glutamate metabolism	9/1562	37/8135	0.2704	0.6583	0.593	GLS2/ALDH4A1/ASPA/FOLH1/GLS/GOT2/ASS1/GLUL/CAD	9
KEGG	hsa03430	Mismatch repair	6/1562	23/8135	0.2708	0.6583	0.593	POLD3/MSH2/RPA2/RFC2/POLD4/PCNA	6
KEGG	hsa04964	Proximal tubule bicarbonate reclamation	6/1562	23/8135	0.2708	0.6583	0.593	GLS2/MDH1/ATP1A1/PCK2/GLS/CA2	6
KEGG	hsa04520	Adherens junction	16/1562	71/8135	0.2791	0.6734	0.6067	RAC2/CDC42/PTPN6/IQGAP1/CSNK2A1/ACTG1/PTPRB/CTNNB1/INSR/NLK/MAPK1/ERBB2/CSNK2A3/SSX2IP/SMAD3/EP300	16
KEGG	hsa00860	Porphyrin metabolism	10/1562	43/8135	0.3041	0.7267	0.6547	HEPHL1/ALAS1/HMOX2/PPOX/UGT2B7/EARS2/COX15/CPOX/UGT2B10/HMBS	10
KEGG	hsa05222	Small cell lung cancer	20/1562	92/8135	0.3055	0.7267	0.6547	NFKBIA/CDKN1A/GADD45B/TRAF4/ITGA3/NFKB1/AKT3/CCND1/POLK/IKBKB/PIK3CD/RXRB/TRAF6/PIK3CA/BIRC3/CDK4/TRAF5/LAMC3/PTEN/CKS1B	20
KEGG	hsa04390	Hippo signaling pathway	33/1562	157/8135	0.3096	0.727	0.655	TGFB3/PPP2CA/AREG/BBC3/SMAD7/PPP2R2B/ACTG1/PPP2R1A/LIMD1/WTIP/MOB1A/RASSF1/CCND1/TP73/CTNNB1/FRMD6/WNT11/NF2/WNT3/AMOT/DLG4/BIRC3/WNT16/CCND3/PPP1CA/TEAD4/CRB2/WNT6/SMAD3/FZD3/SAV1/SMAD2/CRB1	33
KEGG	hsa04664	Fc epsilon RI signaling pathway	15/1562	68/8135	0.3189	0.727	0.655	RAC2/AKT3/MAP2K6/INPP5D/PLCG2/ALOX5AP/MAPK8/PIK3CD/PIK3CA/MAPK1/BTK/PLA2G4C/GRB2/LYN/VAV2	15
KEGG	hsa00730	Thiamine metabolism	4/1562	15/8135	0.322	0.727	0.655	AK2/ALPP/THTPA/NTPCR	4
KEGG	hsa03020	RNA polymerase	8/1562	34/8135	0.3228	0.727	0.655	POLR3D/TWISTNB/POLR3GL/POLR3B/POLR3K/POLR2A/POLR2F/ZNRD1	8
KEGG	hsa01522	Endocrine resistance	21/1562	98/8135	0.3246	0.727	0.655	CDKN1A/ABCB11/FOS/AKT3/CCND1/MDM2/NOTCH4/SHC3/MAPK8/JUN/PIK3CD/GNAS/PIK3CA/NOTCH2/ESR1/MAPK1/PRKACB/ERBB2/CDK4/GRB2/ADCY2	21
KEGG	hsa05231	Choline metabolism in cancer	21/1562	98/8135	0.3246	0.727	0.655	HIF1A/RAC2/FOS/RHEB/DGKH/AKT3/SLC44A4/DGKG/PIP5K1A/GPCPD1/DGKB/MAPK8/JUN/PIK3CD/PIK3CA/MAPK1/TSC1/PLA2G4C/GRB2/PLD1/SLC44A2	21
KEGG	hsa03013	Nucleocytoplasmic transport	23/1562	108/8135	0.3252	0.727	0.655	NXT1/DDX19B/AHCTF1/TMEM33/NUP210L/NUP43/RANBP2/THOC7/THOC3/SUMO2/UPF3B/EIF4A3/NUP37/SNUPN/XPO5/NUP153/IPO13/IPO7/ALYREF/AAAS/RBM8A/RANBP17/SRRM1	23
KEGG	hsa04931	Insulin resistance	23/1562	108/8135	0.3252	0.727	0.655	NFKBIA/SOCS3/IRS2/NR1H2/CREB3L4/SLC27A4/NFKB1/AKT3/SLC27A6/PCK2/INSR/MAPK8/IKBKB/PIK3CD/OGT/PIK3CA/RPS6KA1/PPARGC1A/PPP1CA/PTEN/IRS1/PPARGC1B/PRKCD	23
KEGG	hsa00230	Purine metabolism	27/1562	128/8135	0.3253	0.727	0.655	GUK1/DCK/NUDT9/ENPP1/HDDC2/HDDC3/AMPD3/ADK/PDE4B/ENTPD1/PDE11A/PDE7A/PDE9A/AMPD1/PRPS2/XDH/PDE6A/AK2/PDE1A/GART/PDE6D/ADCY2/RRM2B/DGUOK/NTPCR/APRT/NUDT5	27
KEGG	hsa05203	Viral carcinogenesis	42/1562	204/8135	0.3322	0.7375	0.6645	NFKBIA/CDKN1A/IL6ST/CDC42/PMAIP1/ATF4/GTF2A1/DDX3X/CREB3L4/VDAC3/HLA-B/NFKB1/HDAC1/DNAJA3/CCND1/HDAC2/RANBP1/STAT5B/MDM2/GTF2H1/MRPS18B/JUN/PIK3CD/PIK3CA/HLA-E/IRF3/MAPK1/PRKACB/CDK4/TRAF5/HLA-A/TRADD/CCND3/HLA-F/GRB2/LYN/RBPJ/SRF/HDAC9/DDB1/EP300/CCNA2	42
KEGG	hsa04330	Notch signaling pathway	13/1562	59/8135	0.3384	0.7464	0.6724	DTX3L/CIR1/ATXN1L/HDAC1/HDAC2/HES1/NOTCH4/NUMBL/NOTCH2/CTBP1/MFNG/RBPJ/EP300	13
KEGG	hsa04625	C-type lectin receptor signaling pathway	22/1562	104/8135	0.3428	0.7511	0.6767	NFKBIA/CALM2/BCL3/CYLD/NFKB1/AKT3/CCL17/PLCG2/MDM2/MAPK8/JUN/IKBKB/PIK3CD/RELB/PIK3CA/MAPK1/CASP1/IRF1/IKBKE/NFATC2/PRKCD/STAT2	22
KEGG	hsa04730	Long-term depression	13/1562	60/8135	0.3625	0.7845	0.7067	GNA13/PPP2CA/CACNA1A/PPP2R1A/GNAI1/PPP1R17/GRIA3/GNAS/MAPK1/GNA12/PLA2G4C/GRIA2/LYN	13
KEGG	hsa01232	Nucleotide metabolism	18/1562	85/8135	0.3628	0.7845	0.7067	DUT/GUK1/DCK/ENPP1/HDDC2/AMPD3/ADK/DCTPP1/ENTPD1/AMPD1/XDH/AK2/ASMTL/RRM2B/DGUOK/DTYMK/NTPCR/APRT	18
KEGG	hsa00360	Phenylalanine metabolism	4/1562	16/8135	0.3699	0.7947	0.7159	MAOB/HPD/GOT2/MAOA	4
KEGG	hsa04360	Axon guidance	37/1562	182/8135	0.3772	0.8035	0.7239	RAC2/CDC42/SEMA4F/TRPC1/MYL12A/EFNA3/BOC/PLXNA4/CXCR4/ENAH/LRRC4C/GNAI1/MYL12B/DPYSL5/PLCG2/EFNA4/EPHA3/EPHA6/SEMA7A/PIK3CD/PAK2/PIK3CA/NTNG1/MAPK1/DCC/ROCK2/SMO/SEMA3G/NFATC2/FZD3/EPHA7/RND1/SLIT2/PTCH1/SEMA4B/UNC5D/SEMA3E	37
KEGG	hsa04950	Maturity onset diabetes of the young	6/1562	26/8135	0.3818	0.8035	0.7239	NEUROD1/HES1/RFX6/HHEX/FOXA2/HNF4G	6
KEGG	hsa00410	beta-Alanine metabolism	7/1562	31/8135	0.3845	0.8035	0.7239	HIBCH/MLYCD/ALDH7A1/ACOX3/CNDP2/ALDH3A2/ALDH1B1	7
KEGG	hsa00350	Tyrosine metabolism	8/1562	36/8135	0.3861	0.8035	0.7239	ADH6/MAOB/HPD/FAHD1/GOT2/MAOA/TPO/DCT	8
KEGG	hsa00760	Nicotinate and nicotinamide metabolism	8/1562	36/8135	0.3861	0.8035	0.7239	NMNAT1/NAMPT/ENPP1/SIRT5/NNT/SIRT4/NUDT12/NMNAT2	8
KEGG	hsa04914	Progesterone-mediated oocyte maturation	21/1562	102/8135	0.3992	0.8258	0.7439	ANAPC16/ANAPC15/CPEB3/AKT3/GNAI1/SPDYE6/CDC26/AURKA/MAPK8/SPDYE2B/PIK3CD/PIK3CA/RPS6KA1/MAPK1/PRKACB/ANAPC7/CDC23/ADCY2/HSP90AB1/HSP90AA1/CCNA2	21
KEGG	hsa05010	Alzheimer disease	76/1562	384/8135	0.4027	0.8278	0.7458	PSMA8/DDIT3/KIF5C/ATF4/CALM2/IRS2/UQCRFS1/TUBB2A/UQCR10/ATG2A/VDAC3/SDHD/COX4I1/VDAC2/CSNK2A1/SLC39A10/NDUFB3/CAPN1/TUBB4A/SDHA/MAPT/LPL/NFKB1/TUBB2B/AKT3/XBP1/KIF5A/NDUFA8/RB1CC1/NDUFS2/PPIF/NDUFB1/ATG13/PSMD4/TUBB4B/NDUFB5/CACNA1C/CTNNB1/WNT11/WNT3/INSR/CYC1/MAPK8/IKBKB/PIK3CD/CHRM3/PSMA7/SDHC/PSMC2/FRAT1/PIK3CA/BACE2/MAPK1/WNT16/PSMB2/COX7C/ULK1/CASP12/CSNK2A3/CHRNA7/COX6B2/WNT6/SDHB/IRS1/SLC39A1/KIF5B/PSMA3/FZD3/DKK4/COX7A2L/NDUFA7/ADAM10/EIF2S1/NDUFA12/MAP3K5/PSMD7	76
KEGG	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1562	77/8135	0.4068	0.8291	0.7469	ACTG1/CACNG2/EMD/ITGA3/CACNG8/SGCA/CACNA1C/CTNNB1/SGCB/ITGA4/ITGA1/ITGA10/ITGA8/ITGB7/CACNA2D2/ITGB6	16
KEGG	hsa00982	Drug metabolism - cytochrome P450	15/1562	72/8135	0.4083	0.8291	0.7469	GSTM5/CYP3A5/ADH6/CYP2C9/GSTT1/MAOB/UGT2B7/CYP2C19/CYP2A7/FMO4/MAOA/GSTA1/GSTM4/FMO1/UGT2B10	15
KEGG	hsa05134	Legionellosis	12/1562	57/8135	0.4128	0.8307	0.7484	NFKBIA/HSPA8/CLK1/HSPA1B/HSPA1A/ARF1/NFKB1/SAR1A/RAB1A/SEC22B/CASP1/HSPA1L	12
KEGG	hsa04974	Protein digestion and absorption	21/1562	103/8135	0.4183	0.8307	0.7484	SLC3A2/CTRL/COL6A5/CELA3A/DPP4/ATP1A1/COL27A1/ELN/CPB2/COL25A1/SLC6A19/SLC36A2/KCNJ13/COL9A1/SLC36A3/SLC3A1/XPNPEP2/MEP1B/COL23A1/MEP1A/COL5A1	21
KEGG	hsa00062	Fatty acid elongation	6/1562	27/8135	0.4193	0.8307	0.7484	HSD17B12/ELOVL1/ELOVL5/TECR/HADHB/HADH	6
KEGG	hsa01040	Biosynthesis of unsaturated fatty acids	6/1562	27/8135	0.4193	0.8307	0.7484	HSD17B4/HSD17B12/ELOVL1/ELOVL5/ACOX3/TECR	6
KEGG	hsa04912	GnRH signaling pathway	19/1562	93/8135	0.4223	0.8307	0.7484	CDC42/ATF4/CALM2/CGA/MAP2K6/PTK2B/LHB/GNRH1/CACNA1C/MAPK8/JUN/GNAS/MAPK1/PRKACB/PLA2G4C/GRB2/PLD1/ADCY2/PRKCD	19
KEGG	hsa05131	Shigellosis	49/1562	247/8135	0.4241	0.8307	0.7484	NFKBIA/UBE2D3/UBC/CDC42/MYL12A/NFKBIB/ARF1/CASP4/ARPC3/CAPN1/ATG12/TLN2/ACTG1/NFKB1/AKT3/UBE2D2/ARPC5/GLMN/ARHGEF2/HCLS1/MYL12B/ACTR2/MAP1LC3B/PLCG2/MDM2/RIPK2/SQSTM1/RIPK1/MAPK8/JUN/IKBKB/PIK3CD/UBE2V2/CRK/TRAF6/PIK3CA/IRF3/MAPK1/ROCK2/CASP1/TRAF5/CD44/TRADD/GSK3A/PLCE1/ACTR3B/PRKCD/TIFA/MYL7	49
KEGG	hsa04611	Platelet activation	25/1562	124/8135	0.4282	0.8339	0.7512	GNA13/MYL12A/TLN2/VAMP8/ACTG1/AKT3/PPP1R12A/GNAI1/MYL12B/PLCG2/PIK3CD/GNAS/PIK3CA/MAPK1/APBB1IP/PRKACB/ROCK2/BTK/PPP1CA/PLA2G4C/RASGRP2/SNAP23/ADCY2/LYN/TBXA2R	25
KEGG	hsa04620	Toll-like receptor signaling pathway	21/1562	104/8135	0.4374	0.839	0.7558	NFKBIA/FOS/MAP3K8/TLR9/NFKB1/AKT3/MAP2K6/RIPK1/MAPK8/JUN/IKBKB/PIK3CD/TRAF6/PIK3CA/IRF3/MAPK1/IKBKE/IFNA1/TICAM2/CD40/LY96	21
KEGG	hsa04660	T cell receptor signaling pathway	21/1562	104/8135	0.4374	0.839	0.7558	NFKBIA/CDC42/PTPN6/FOS/MAP3K8/PTPRC/NFKBIB/NFKBIE/NFKB1/AKT3/MAPK8/JUN/IKBKB/PIK3CD/PAK2/PIK3CA/MAPK1/CDK4/GRB2/NFATC2/VAV2	21
KEGG	hsa05213	Endometrial cancer	12/1562	58/8135	0.4384	0.839	0.7558	CDKN1A/GADD45B/AKT3/CCND1/POLK/CTNNB1/PIK3CD/PIK3CA/MAPK1/ERBB2/PTEN/GRB2	12
KEGG	hsa04727	GABAergic synapse	18/1562	89/8135	0.4451	0.8452	0.7615	GABRG2/SLC6A11/CACNA1B/GLS2/GABRB3/CACNA1A/GABARAPL1/GNAI1/GABRB2/CACNA1C/GABARAPL2/GLS/PRKACB/GABRA4/GABRA5/ADCY2/GLUL/PLCL1	18
KEGG	hsa04975	Fat digestion and absorption	9/1562	43/8135	0.4467	0.8452	0.7615	PLA2G2D/SLC27A4/FABP2/GOT2/MOGAT3/PNLIP/PLA2G5/ACAT1/ABCA1	9
KEGG	hsa00650	Butanoate metabolism	6/1562	28/8135	0.4565	0.8549	0.7702	HMGCL/BDH2/ACSM2A/ACAT1/HADH/BDH1	6
KEGG	hsa05204	Chemical carcinogenesis - DNA adducts	14/1562	69/8135	0.457	0.8549	0.7702	NAT1/GSTM5/CYP3A5/CYP2C9/GSTT1/HSD11B1/UGT2B7/CBR1/CYP2C19/CYP2A7/GSTA1/GSTM4/CYP2A13/UGT2B10	14
KEGG	hsa04120	Ubiquitin mediated proteolysis	28/1562	142/8135	0.4714	0.864	0.7784	UBE2D3/UBC/SOCS3/ANAPC16/KLHL9/ANAPC15/TRIM32/RHOBTB2/UBE2D2/NEDD4/AIRE/SMURF1/UBE2J2/MDM2/CDC26/KEAP1/UBE2E2/HERC4/TRAF6/BIRC3/UBE2S/UBE2M/FBXO2/ANAPC7/CDC23/DDB1/UBE3B/UBE2Z	28
KEGG	hsa04936	Alcoholic liver disease	28/1562	142/8135	0.4714	0.864	0.7784	NFKBIA/TRA2B/MLYCD/NFKB1/AKT3/MAP2K6/CCND1/LPIN3/ADH6/RIPK1/CTNNB1/MAPK8/IKBKB/ACADM/ALDH7A1/TRAF6/ACOX3/IRF3/TRADD/PPARGC1A/IKBKE/IFNA1/TRA2A/LY96/ALDH3A2/MAP3K5/ADIPOQ/ALDH1B1	28
KEGG	hsa05163	Human cytomegalovirus infection	44/1562	225/8135	0.473	0.864	0.7784	NFKBIA/CDKN1A/RAC2/GNA13/ATF4/CALM2/PTGER4/CREB3L4/IL10RB/RHEB/HLA-B/NFKB1/AKT3/CXCR4/MAP2K6/PTK2B/GNAI1/CCND1/MDM2/RIPK1/CTNNB1/IKBKB/PIK3CD/CRK/GNAS/PIK3CA/HLA-E/IRF3/MAPK1/PRKACB/ROCK2/CDK4/TRAF5/HLA-A/TRADD/IL10RA/TSC1/GNA12/TAP1/HLA-F/GRB2/IFNA1/ADCY2/NFATC2	44
KEGG	hsa05225	Hepatocellular carcinoma	33/1562	168/8135	0.4731	0.864	0.7784	CDKN1A/GADD45B/TGFB3/NQO1/ACTG1/AKT3/GSTM5/SMARCC2/CCND1/PLCG2/POLK/SHC3/ACTL6A/CTNNB1/WNT11/WNT3/GSTT1/KEAP1/PIK3CD/FRAT1/PIK3CA/MAPK1/TXNRD2/WNT16/CDK4/PTEN/WNT6/GRB2/SMAD3/FZD3/GSTA1/GSTM4/SMAD2	33
KEGG	hsa05214	Glioma	15/1562	75/8135	0.4764	0.864	0.7784	CDKN1A/CALM2/GADD45B/AKT3/CCND1/PLCG2/MDM2/POLK/SHC3/PIK3CD/PIK3CA/MAPK1/CDK4/PTEN/GRB2	15
KEGG	hsa04728	Dopaminergic synapse	26/1562	132/8135	0.4774	0.864	0.7784	KIF5C/ATF4/FOS/CALM2/PPP2CA/CREB3L4/CACNA1B/PPP2R2B/CACNA1A/AKT3/PPP2R1A/KIF5A/PPP2R3B/GNAI1/CACNA1C/GRIA3/MAPK8/MAOB/GNAS/PRKACB/SCN1A/GSK3A/PPP1CA/GRIA2/MAOA/KIF5B	26
KEGG	hsa05414	Dilated cardiomyopathy	19/1562	96/8135	0.4825	0.8686	0.7825	TGFB3/ACTG1/CACNG2/EMD/ITGA3/CACNG8/SGCA/CACNA1C/SGCB/ITGA4/ITGA1/ITGA10/GNAS/PRKACB/ITGA8/ITGB7/CACNA2D2/ADCY2/ITGB6	19
KEGG	hsa05017	Spinocerebellar ataxia	28/1562	143/8135	0.4879	0.8734	0.7869	PSMA8/ATG2A/VDAC3/VDAC2/CACNA1A/AKT3/ATXN1L/XBP1/RB1CC1/PPIF/ATG13/ATXN2/PSMD4/OMA1/GRIA3/MAPK8/PIK3CD/PSMA7/PSMC2/PIK3CA/PSMB2/ULK1/GRIA2/PSMA3/ATXN3/RBPJ/MAP3K5/PSMD7	28
KEGG	hsa05142	Chagas disease	20/1562	102/8135	0.4984	0.8875	0.7996	NFKBIA/FOS/TGFB3/PPP2CA/PPP2R2B/TLR9/NFKB1/AKT3/PPP2R1A/GNAI1/MAPK8/JUN/IKBKB/PIK3CD/GNAS/TRAF6/PIK3CA/MAPK1/KNG1/SMAD2	20
KEGG	hsa01210	2-Oxocarboxylic acid metabolism	4/1562	19/8135	0.5097	0.9011	0.8118	NAGS/IDH1/BCAT2/GOT2	4
KEGG	hsa00190	Oxidative phosphorylation	26/1562	134/8135	0.5114	0.9011	0.8118	UQCRFS1/ATP6V0E1/UQCR10/ATP6V1B1/SDHD/COX4I1/ATP6V1D/NDUFB3/SDHA/NDUFA8/NDUFS2/NDUFB1/NDUFB5/CYC1/ATP6V1G3/SDHC/ATP6V1G1/ATP6V1F/COX15/ATP6V1A/COX7C/COX6B2/SDHB/COX7A2L/NDUFA7/NDUFA12	26
KEGG	hsa00561	Glycerolipid metabolism	12/1562	61/8135	0.5143	0.9015	0.8121	DGKH/LPL/AGK/DGKG/LPIN3/LCLAT1/DGKB/ALDH7A1/MOGAT3/PNLIP/ALDH3A2/ALDH1B1	12
KEGG	hsa00564	Glycerophospholipid metabolism	19/1562	98/8135	0.5222	0.9078	0.8178	PLA2G2D/ETNK1/LYPLA2/DGKH/PLD4/DGKG/LPIN3/GPCPD1/LCLAT1/DGKB/PLA2G5/CRLS1/PLA2G4C/GNPAT/PLD1/PTDSS1/TAZ/LPCAT3/LPCAT1	19
KEGG	hsa00030	Pentose phosphate pathway	6/1562	30/8135	0.5289	0.9078	0.8178	ALDOC/RBKS/PRPS2/PFKL/ALDOB/RPE	6
KEGG	hsa00053	Ascorbate and aldarate metabolism	6/1562	30/8135	0.5289	0.9078	0.8178	ALDH7A1/UGT2B7/UGDH/ALDH3A2/UGT2B10/ALDH1B1	6
KEGG	hsa01523	Antifolate resistance	6/1562	30/8135	0.5289	0.9078	0.8178	NFKB1/ABCC5/SHMT2/IKBKB/GART/ABCG2	6
KEGG	hsa04640	Hematopoietic cell lineage	19/1562	99/8135	0.5418	0.923	0.8315	IL7/ITGA3/IL2RA/HLA-DOB/HLA-DRA/GYPA/CR2/ITGA4/HLA-DOA/ITGA1/HLA-DMB/HLA-DPA1/MS4A1/CD44/HLA-DPB1/CD19/CD37/IL9R/HLA-DQA1	19
KEGG	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/1562	78/8135	0.5433	0.923	0.8315	GSTM5/CYP3A5/ADH6/CYP2C9/GSTT1/HSD11B1/UGT2B7/CBR1/CBR3/CYP2A7/CYP2F1/GSTA1/GSTM4/CYP2A13/UGT2B10	15
KEGG	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1562	194/8135	0.548	0.9257	0.834	CD200R1/NFKBIA/HIF1A/CDKN1A/UBC/IL6ST/CD200R1L/FOS/CALM2/CLEC2B/ZFP36/HLA-B/NFKB1/AKT3/MAP2K6/CCND1/MAP1LC3B/PLCG2/CTNNB1/MAPK8/JUN/IKBKB/PIK3CD/PIK3CA/HLA-E/IRF3/MAPK1/CDK4/HLA-A/TRADD/IKBKE/HLA-F/IFNA1/LYN/NFATC2/STAT2/EP300	37
KEGG	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1562	20/8135	0.5532	0.9257	0.834	CHST12/CHST15/UST/CHST11	4
KEGG	hsa00670	One carbon pool by folate	4/1562	20/8135	0.5532	0.9257	0.834	MTFMT/SHMT2/MTHFD1L/GART	4
KEGG	hsa03420	Nucleotide excision repair	9/1562	47/8135	0.5625	0.9366	0.8437	POLD3/GTF2H5/XPA/RPA2/GTF2H1/RFC2/POLD4/PCNA/DDB1	9
KEGG	hsa04510	Focal adhesion	38/1562	201/8135	0.5719	0.9433	0.8498	RAC2/CDC42/MYL12A/TLN2/ACTG1/ITGA3/AKT3/PPP1R12A/COL6A5/MYL12B/CCND1/SHC3/CTNNB1/PIP5K1A/ITGA4/ITGA1/MAPK8/JUN/PIK3CD/ITGA10/PAK2/CRK/PIK3CA/MAPK1/BIRC3/ROCK2/ERBB2/ITGA8/ITGB7/CCND3/PPP1CA/LAMC3/COL9A1/PTEN/GRB2/VAV2/ITGB6/MYL7	38
KEGG	hsa05152	Tuberculosis	34/1562	180/8135	0.5734	0.9433	0.8498	CALM2/CORO1A/TGFB3/IL10RB/HSPA9/EEA1/TLR9/NFKB1/AKT3/HLA-DOB/RFXAP/CEBPG/CASP10/MRC1/HLA-DRA/RIPK2/RAB5B/HLA-DOA/HLA-DMB/MAPK8/SPHK2/HLA-DPA1/TRAF6/MAPK1/FCGR2B/RAB7A/TRADD/IL10RA/NFYC/IFNA1/HLA-DPB1/RAB5C/EP300/HLA-DQA1	34
KEGG	hsa04915	Estrogen signaling pathway	26/1562	138/8135	0.5779	0.9433	0.8498	ATF4/FOS/CALM2/HSPA8/CREB3L4/HSPA1B/HSPA1A/AKT3/GNAI1/SHC3/JUN/PIK3CD/GNAS/PIK3CA/RARA/ESR1/MAPK1/PRKACB/HSP90B1/KRT10/GRB2/ADCY2/HSP90AB1/HSPA1L/PRKCD/HSP90AA1	26
KEGG	hsa05170	Human immunodeficiency virus 1 infection	40/1562	212/8135	0.5779	0.9433	0.8498	NFKBIA/RAC2/FOS/CALM2/APOBEC3F/HLA-B/NFKB1/AKT3/CXCR4/MAP2K6/TRIM5/PTK2B/GNAI1/APOBEC3C/AP1S1/PLCG2/WEE1/RIPK1/MAPK8/JUN/IKBKB/PIK3CD/PAK2/CRK/APOBEC3G/TRAF6/PIK3CA/HLA-E/IRF3/MAPK1/APOBEC3D/TRAF5/HLA-A/TRADD/WEE2/TAP1/HLA-F/IFNA1/NFATC2/DDB1	40
KEGG	hsa04960	Aldosterone-regulated sodium reabsorption	7/1562	37/8135	0.5836	0.9434	0.8499	ATP1A1/INSR/PIK3CD/PIK3CA/MAPK1/SGK1/IRS1	7
KEGG	hsa05216	Thyroid cancer	7/1562	37/8135	0.5836	0.9434	0.8499	CDKN1A/GADD45B/CCND1/POLK/CTNNB1/RXRB/MAPK1	7
KEGG	hsa04918	Thyroid hormone synthesis	14/1562	75/8135	0.5936	0.951	0.8567	HSPA5/ATF4/CREB3L4/TSHB/CGA/ATP1A1/SLC5A5/GNAS/PRKACB/HSP90B1/ADCY2/TPO/DUOX1/GSR	14
KEGG	hsa04934	Cushing syndrome	29/1562	155/8135	0.595	0.951	0.8567	CDKN1A/ATF4/CREB3L4/RBBP5/WDR5B/FH/ASH2L/GNAI1/CCND1/PDE11A/CACNA1C/CTNNB1/WNT11/WNT3/CACNA1G/GNAS/NR4A1/AHR/MAPK1/MEN1/WNT16/PRKACB/CDK4/AIP/ARNT/WNT6/ADCY2/FZD3/PBX1	29
KEGG	hsa04215	Apoptosis - multiple species	6/1562	32/8135	0.5969	0.951	0.8567	PMAIP1/BBC3/BCL2L11/MAPK8/HTRA2/BIRC3	6
KEGG	hsa00920	Sulfur metabolism	2/1562	10/8135	0.5997	0.951	0.8567	BPNT1/SUOX	2
KEGG	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1562	27/8135	0.6131	0.9548	0.8601	FUT7/B3GALT2/FUT2/FUT1/GCNT2	5
KEGG	hsa05133	Pertussis	14/1562	76/8135	0.615	0.9548	0.8601	FOS/CALM2/NFKB1/GNAI1/MAPK8/JUN/TRAF6/IRF3/MAPK1/CASP1/IRF1/C1R/TICAM2/LY96	14
KEGG	hsa04022	cGMP-PKG signaling pathway	31/1562	167/8135	0.6152	0.9548	0.8601	RGS2/GNA13/ATF4/CALM2/IRS2/CREB3L4/VDAC3/VDAC2/MEF2D/AKT3/PPP1R12A/PPIF/ATP2B1/GNAI1/ATP1A1/CACNA1C/INSR/ADRA1A/MAPK1/GTF2IRD1/ROCK2/KCNU1/KNG1/GNA12/PPP1CA/IRS1/ADCY2/NFATC2/ATP2B2/SRF/GTF2I	31
KEGG	hsa04310	Wnt signaling pathway	31/1562	167/8135	0.6152	0.9548	0.8601	RAC2/PRICKLE1/CSNK2A1/PRICKLE3/CBY1/CXXC4/CCND1/DAAM1/CTNNB1/WNT11/WNT3/MAPK8/JUN/FRAT1/NLK/RUVBL1/WNT16/PRKACB/CTBP1/ROCK2/TBL1XR1/VANGL1/CCND3/FRZB/CSNK2A3/WNT6/SMAD3/NFATC2/FZD3/DKK4/EP300	31
KEGG	hsa00565	Ether lipid metabolism	9/1562	49/8135	0.6164	0.9548	0.8601	PLA2G2D/PLD4/GDPD1/PAFAH1B1/PLA2G5/PLA2G4C/GDPD3/PLD1/LPCAT1	9
KEGG	hsa05224	Breast cancer	27/1562	147/8135	0.6354	0.9758	0.8791	CDKN1A/FOS/GADD45B/AKT3/CCND1/HES1/NOTCH4/POLK/SHC3/CTNNB1/WNT11/WNT3/JUN/PIK3CD/FRAT1/PIK3CA/NOTCH2/ESR1/MAPK1/WNT16/ERBB2/CDK4/PTEN/WNT6/GRB2/FGF16/FZD3	27
KEGG	hsa05100	Bacterial invasion of epithelial cells	14/1562	77/8135	0.6359	0.9758	0.8791	CDC42/ARPC3/ACTG1/ARPC5/HCLS1/ACTR2/RHOG/SHC3/CTNNB1/PIK3CD/CRK/PIK3CA/ACTR3B/ARHGAP10	14
KEGG	hsa04910	Insulin signaling pathway	25/1562	137/8135	0.6466	0.98	0.8829	SOCS3/CALM2/IRS2/RHEB/PRKAR1A/MKNK2/LIPE/AKT3/SHC3/SH2B2/PCK2/INSR/MAPK8/IKBKB/PIK3CD/CRK/PIK3CA/MAPK1/PRKACB/PHKB/TSC1/PPARGC1A/PPP1CA/GRB2/IRS1	25
KEGG	hsa04072	Phospholipase D signaling pathway	27/1562	148/8135	0.6502	0.98	0.8829	GNA13/LPAR5/RHEB/ARF1/RAPGEF3/DGKH/AKT3/PTK2B/DGKG/PLCG2/SHC3/GRM3/PIP5K1A/INSR/DGKB/SPHK2/PIK3CD/GNAS/PIK3CA/MAPK1/LPAR4/TSC1/GNA12/PLA2G4C/GRB2/PLD1/ADCY2	27
KEGG	hsa04340	Hedgehog signaling pathway	10/1562	56/8135	0.6543	0.98	0.8829	KIF3A/BOC/DISP1/CCND1/SMURF1/PRKACB/SMO/CDON/HHAT/PTCH1	10
KEGG	hsa03022	Basal transcription factors	8/1562	45/8135	0.6553	0.98	0.8829	GTF2A1/GTF2H5/TAF5/GTF2H1/GTF2IRD1/TAF11/TAF12/GTF2I	8
KEGG	hsa04721	Synaptic vesicle cycle	14/1562	78/8135	0.6561	0.98	0.8829	ATP6V0E1/ATP6V1B1/SLC6A11/ATP6V1D/CACNA1B/CACNA1A/CPLX4/SLC6A4/ATP6V1G3/SLC6A2/ATP6V1G1/ATP6V1F/ATP6V1A/SLC17A8	14
KEGG	hsa00910	Nitrogen metabolism	3/1562	17/8135	0.6611	0.98	0.8829	GLUL/CA2/CA12	3
KEGG	hsa04062	Chemokine signaling pathway	35/1562	192/8135	0.6641	0.98	0.8829	NFKBIA/RAC2/CDC42/CCR6/NFKBIB/NFKB1/AKT3/CCL17/CXCR4/PTK2B/GNAI1/STAT5B/PLCG2/SHC3/NCF1/IKBKB/PIK3CD/CRK/GRK6/PIK3CA/MAPK1/CCL16/PRKACB/ROCK2/GSK3A/RASGRP2/XCL1/FGR/GRB2/ADCY2/LYN/VAV2/CCR9/PRKCD/STAT2	35
KEGG	hsa00270	Cysteine and methionine metabolism	9/1562	51/8135	0.6667	0.98	0.8829	MAT2B/LDHB/MDH1/AHCYL1/APIP/BCAT2/GOT2/GCLM/PHGDH	9
KEGG	hsa04913	Ovarian steroidogenesis	9/1562	51/8135	0.6667	0.98	0.8829	CGA/LHB/HSD17B1/HSD17B7/INSR/GNAS/PRKACB/PLA2G4C/ADCY2	9
KEGG	hsa05410	Hypertrophic cardiomyopathy	16/1562	90/8135	0.6764	0.98	0.8829	TGFB3/ACTG1/CACNG2/EMD/ITGA3/CACNG8/SGCA/CACNA1C/SGCB/ITGA4/ITGA1/ITGA10/ITGA8/ITGB7/CACNA2D2/ITGB6	16
KEGG	hsa00591	Linoleic acid metabolism	5/1562	29/8135	0.6792	0.98	0.8829	PLA2G2D/CYP2C9/CYP2C19/PLA2G5/PLA2G4C	5
KEGG	hsa04744	Phototransduction	5/1562	29/8135	0.6792	0.98	0.8829	CALM2/SLC24A1/GNAT2/PDE6A/GUCA1A	5
KEGG	hsa04922	Glucagon signaling pathway	19/1562	107/8135	0.6866	0.98	0.8829	SIK1/ATF4/CALM2/CREB3L4/LDHB/PRMT1/AKT3/PDHB/PCK2/GNAS/PRKACB/PHKB/PDHA1/PFKL/PPARGC1A/PGAM2/ADCY2/SIK2/EP300	19
KEGG	hsa05217	Basal cell carcinoma	11/1562	63/8135	0.6871	0.98	0.8829	CDKN1A/GADD45B/POLK/CTNNB1/WNT11/WNT3/WNT16/WNT6/SMO/FZD3/PTCH1	11
KEGG	hsa04015	Rap1 signaling pathway	38/1562	210/8135	0.6871	0.98	0.8829	RAC2/CDC42/CALM2/LPAR5/FGFR2/EFNA3/ANGPT1/TLN2/RAPGEF3/ACTG1/AKT3/MAP2K6/ENAH/KRIT1/GNAI1/CTNNB1/EFNA4/INSR/PRKD1/PIK3CD/CRK/GNAS/PIK3CA/MAPK1/APBB1IP/SIPA1/LPAR4/RASGRP2/PLCE1/ADCY2/FGF16/MAGI1/VAV2/MAGI3/RGS14/PRKD3/TEK/MAGI2	38
KEGG	hsa05205	Proteoglycans in cancer	37/1562	205/8135	0.6918	0.98	0.8829	HIF1A/CDKN1A/CDC42/PTPN6/ERBB4/IQGAP1/ACTG1/AKT3/PPP1R12A/ANK3/HCLS1/CCND1/PLCG2/MDM2/CTNNB1/WNT11/WNT3/PIK3CD/PIK3CA/ESR1/MAPK1/WNT16/PRKACB/ROCK2/ERBB2/NANOG/ANK2/CD44/PPP1CA/PLCE1/WNT6/GRB2/SMO/FZD3/VAV2/PTCH1/SMAD2	37
KEGG	hsa04714	Thermogenesis	42/1562	232/8135	0.6925	0.98	0.8829	UQCRFS1/NDUFAF5/CREB3L4/UQCR10/SDHD/COX4I1/RHEB/NDUFB3/NDUFAF3/ACTG1/SDHA/LIPE/COA3/NDUFA8/NDUFS2/NDUFB1/SMARCC2/NDUFB5/ACTL6A/CYC1/SDHC/GNAS/ACSL5/RPS6KA1/PRKACB/COX15/COX7C/TSC1/PPARGC1A/SLC25A29/COX6B2/GRB2/KDM1A/SDHB/ADCY2/NDUFAF7/COX7A2L/ACSL6/NDUFA7/NDUFA12/COA6/MAP3K5	42
KEGG	hsa05032	Morphine addiction	16/1562	91/8135	0.6942	0.98	0.8829	GABRG2/CACNA1B/GABRB3/CACNA1A/GNAI1/PDE4B/GABRB2/PDE11A/PDE7A/GNAS/GRK6/PRKACB/PDE1A/GABRA4/GABRA5/ADCY2	16
KEGG	hsa05219	Bladder cancer	7/1562	41/8135	0.6968	0.98	0.8829	CDKN1A/RASSF1/CCND1/MDM2/MAPK1/ERBB2/CDK4	7
KEGG	hsa00240	Pyrimidine metabolism	10/1562	58/8135	0.6994	0.98	0.8829	DUT/DCK/ENPP1/HDDC2/DCTPP1/ENTPD1/ASMTL/RRM2B/CAD/DTYMK	10
KEGG	hsa00061	Fatty acid biosynthesis	3/1562	18/8135	0.7005	0.98	0.8829	OXSM/ACSL5/ACSL6	3
KEGG	hsa00514	Other types of O-glycan biosynthesis	8/1562	47/8135	0.705	0.9821	0.8848	ST6GAL1/GALNTL6/GALNT7/OGT/GALNT8/MFNG/GALNT2/C1GALT1C1	8
KEGG	hsa04929	GnRH secretion	11/1562	64/8135	0.7078	0.9821	0.8848	TRPC1/CGA/AKT3/LHB/GNRH1/CACNA1C/CACNA1G/PIK3CD/PIK3CA/MAPK1/KISS1R	11
KEGG	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1562	53/8135	0.7129	0.9833	0.8858	ATP2B1/ATP1A1/KLK1/GNAS/ESR1/PRKACB/ATP2B2/RAB11A/CALB1	9
KEGG	hsa00512	Mucin type O-glycan biosynthesis	6/1562	36/8135	0.7153	0.9833	0.8858	GALNTL6/GALNT7/GALNT8/GCNT1/GALNT2/C1GALT1C1	6
KEGG	hsa04925	Aldosterone synthesis and secretion	17/1562	98/8135	0.7192	0.9833	0.8858	ATF4/CALM2/NR4A2/CREB3L4/LIPE/ATP2B1/ATP1A1/CACNA1C/PRKD1/CACNA1G/GNAS/NR4A1/PRKACB/ATF1/ADCY2/ATP2B2/PRKD3	17
KEGG	hsa04370	VEGF signaling pathway	10/1562	59/8135	0.7205	0.9833	0.8858	RAC2/CDC42/AKT3/PLCG2/SPHK2/PIK3CD/PIK3CA/MAPK1/PLA2G4C/NFATC2	10
KEGG	hsa04726	Serotonergic synapse	20/1562	115/8135	0.7258	0.9865	0.8887	DUSP1/TRPC1/CACNA1B/GABRB3/CACNA1A/RAPGEF3/GNAI1/GABRB2/SLC6A4/CYP2C9/CACNA1C/MAOB/GNAS/MAPK1/PRKACB/CYP2C19/PLA2G4C/MAOA/HTR3D/CYP4X1	20
KEGG	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1562	143/8135	0.7325	0.9912	0.893	IL6ST/SMAD9/FGFR2/PCGF5/AKT3/BMI1/ISL1/SKIL/CTNNB1/WNT11/WNT3/PIK3CD/PIK3CA/ID4/MAPK1/WNT16/NODAL/NANOG/WNT6/GRB2/SMAD3/FZD3/SMAD2/PCGF6/ZFHX3	25
KEGG	hsa00592	alpha-Linolenic acid metabolism	4/1562	25/8135	0.7352	0.9912	0.893	PLA2G2D/ACOX3/PLA2G5/PLA2G4C	4
KEGG	hsa04978	Mineral absorption	10/1562	60/8135	0.7406	0.9944	0.8959	HEPHL1/FTH1/ATP2B1/ATP1A1/SLC6A19/HMOX2/STEAP1/ATP2B2/SLC5A1/SLC26A3	10
KEGG	hsa04024	cAMP signaling pathway	39/1562	221/8135	0.7492	0.9984	0.8994	NFKBIA/RAC2/FOS/CALM2/CREB3L4/TSHB/CGA/RAPGEF3/NFKB1/LIPE/AKT3/PPP1R12A/ATP2B1/GNAI1/PDE4B/LHB/ATP1A1/CACNA1C/GRIA3/MAPK8/JUN/PIK3CD/GNAS/PIK3CA/ACOX3/MAPK1/PRKACB/ROCK2/PPP1CA/PLCE1/GRIA2/PLD1/ADCY2/NPY/VAV2/PTCH1/ATP2B2/SSTR2/EP300	39
KEGG	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1562	100/8135	0.7505	0.9984	0.8994	CDC42/TGFB3/NFKB1/AKT3/CCND1/STAT5B/PLCG2/MAPK8/JUN/PIK3CD/PIK3CA/MAPK1/CDK4/PLCE1/SMAD3/PRKCD/SMAD2	17
KEGG	hsa05218	Melanoma	12/1562	72/8135	0.7525	0.9984	0.8994	CDKN1A/GADD45B/AKT3/CCND1/MDM2/POLK/PIK3CD/PIK3CA/MAPK1/CDK4/PTEN/FGF16	12
KEGG	hsa04928	Parathyroid hormone synthesis, secretion and action	18/1562	106/8135	0.7566	0.9998	0.9007	CDKN1A/GNA13/ATF4/FOS/NR4A2/CREB3L4/MEF2D/JUND/GNAI1/PDE4B/GNAS/RXRB/MAPK1/PRKACB/GNA12/PLD1/ADCY2/MMP16	18
KEGG	hsa00790	Folate biosynthesis	4/1562	26/8135	0.764	1	0.9009	MOCS2/PTS/CBR1/ALPP	4
KEGG	hsa05221	Acute myeloid leukemia	11/1562	67/8135	0.7647	1	0.9009	NFKB1/AKT3/CCND1/STAT5B/IKBKB/PIK3CD/PIK3CA/RARA/MAPK1/GRB2/CCNA2	11
KEGG	hsa00100	Steroid biosynthesis	3/1562	20/8135	0.7685	1	0.9009	HSD17B7/DHCR24/FDFT1	3
KEGG	hsa04979	Cholesterol metabolism	8/1562	50/8135	0.7704	1	0.9009	ABCB11/VDAC3/VDAC2/LPL/PLTP/VAPB/MYLIP/ABCA1	8
KEGG	hsa04972	Pancreatic secretion	17/1562	102/8135	0.7794	1	0.9009	PLA2G2D/TRPC1/CTRL/ATP2B1/CELA3A/ATP1A1/CPB2/CHRM3/GNAS/PNLIP/PLA2G5/ADCY2/ATP2B2/RAB8A/RAB11A/CA2/SLC26A3	17
KEGG	hsa00051	Fructose and mannose metabolism	5/1562	33/8135	0.7873	1	0.9009	ALDOC/FPGT/ENOSF1/PFKL/ALDOB	5
KEGG	hsa04724	Glutamatergic synapse	19/1562	114/8135	0.7891	1	0.9009	TRPC1/GLS2/CACNA1A/GRIK2/GNAI1/CACNA1C/GRM3/GRIA3/GNAS/DLG4/GLS/MAPK1/PRKACB/SLC17A8/PLA2G4C/GRIA2/PLD1/ADCY2/GLUL	19
KEGG	hsa04217	Necroptosis	27/1562	159/8135	0.7918	1	0.9009	TNFAIP3/VDAC3/CYLD/HMGB1/VDAC2/CAPN1/TNFSF10/FTH1/CHMP4A/STAT6/STAT5B/SQSTM1/RIPK1/MAPK8/PARP1/BIRC3/CASP1/TRAF5/TRADD/PLA2G4C/AIFM1/IFNA1/GLUL/HSP90AB1/TICAM2/HSP90AA1/STAT2	27
KEGG	hsa04723	Retrograde endocannabinoid signaling	25/1562	148/8135	0.7934	1	0.9009	GABRG2/CACNA1B/GABRB3/NDUFB3/CACNA1A/NDUFA8/NDUFS2/NDUFB1/GNAI1/GABRB2/NDUFB5/NAPEPLD/CACNA1C/GRIA3/MAPK8/MAPK1/PRKACB/ABHD6/SLC17A8/GRIA2/GABRA4/GABRA5/ADCY2/NDUFA7/NDUFA12	25
KEGG	hsa03008	Ribosome biogenesis in eukaryotes	18/1562	109/8135	0.7974	1	0.9009	NXT1/SBDS/UTP6/CSNK2A1/RPP25L/REXO2/RIOK1/NOP58/WDR43/RCL1/IMP3/TCOF1/FBLL1/UTP14A/CSNK2A3/RPP38/NOP10/NAT10	18
KEGG	hsa04014	Ras signaling pathway	40/1562	232/8135	0.8021	1	0.9009	PLA2G2D/RAC2/CDC42/CALM2/FGFR2/EFNA3/ANGPT1/NFKB1/AKT3/ETS1/SYNGAP1/RASSF1/PLCG2/RALBP1/SHC3/EFNA4/RAB5B/INSR/MAPK8/SHOC2/RASAL3/IKBKB/PIK3CD/PAK2/PIK3CA/MAPK1/PRKACB/PLA2G5/EXOC2/PLA2G4C/RASGRP2/PLCE1/GRB2/PLD1/FGF16/NF1/RAB5C/KSR2/TEK/RASAL2	40
KEGG	hsa04750	Inflammatory mediator regulation of TRP channels	16/1562	98/8135	0.8021	1	0.9009	CALM2/PTGER4/MAP2K6/PLCG2/MAPK8/TRPV2/PIK3CD/GNAS/PIK3CA/PRKACB/KNG1/PPP1CA/PLA2G4C/ADCY2/TRPA1/PRKCD	16
KEGG	hsa05226	Gastric cancer	25/1562	149/8135	0.8044	1	0.9009	CDKN1A/GADD45B/FGFR2/TGFB3/AKT3/CCND1/POLK/SHC3/CTNNB1/WNT11/WNT3/CDH17/PIK3CD/FRAT1/RXRB/PIK3CA/MAPK1/WNT16/ERBB2/WNT6/GRB2/FGF16/SMAD3/FZD3/SMAD2	25
KEGG	hsa00480	Glutathione metabolism	9/1562	58/8135	0.8092	1	0.9009	GSTM5/IDH1/ODC1/GSTT1/GCLM/GSTA1/RRM2B/GSTM4/GSR	9
KEGG	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1562	15/8135	0.8138	1	0.9009	FUT2/FUT1	2
KEGG	hsa04512	ECM-receptor interaction	14/1562	88/8135	0.8214	1	0.9009	HMMR/ITGA3/COL6A5/ITGA4/ITGA1/FRAS1/FREM2/ITGA10/ITGA8/ITGB7/CD44/LAMC3/COL9A1/ITGB6	14
KEGG	hsa04926	Relaxin signaling pathway	21/1562	129/8135	0.8317	1	0.9009	NFKBIA/ATF4/FOS/CREB3L4/NFKB1/AKT3/GNAI1/SHC3/ACTA2/MAPK8/JUN/RXFP1/PIK3CD/GNAS/PIK3CA/MAPK1/PRKACB/RXFP4/GRB2/ADCY2/SMAD2	21
KEGG	hsa00430	Taurine and hypotaurine metabolism	2/1562	16/8135	0.8418	1	0.9009	FMO4/FMO1	2
KEGG	hsa04151	PI3K-Akt signaling pathway	61/1562	354/8135	0.849	1	0.9009	CDKN1A/ATF4/LPAR5/FGFR2/ERBB4/PPP2CA/AREG/CREB3L4/IL7/IL2RG/RHEB/PPP2R2B/EFNA3/BCL2L11/ANGPT1/ITGA3/NFKB1/IL2RA/AKT3/PPP2R1A/PPP2R3B/COL6A5/CCND1/MDM2/PCK2/ITGA4/EFNA4/INSR/ITGA1/IKBKB/PIK3CD/ITGA10/DDIT4/NR4A1/PIK3CA/CDC37/MAPK1/ERBB2/CDK4/ITGA8/ITGB7/HSP90B1/CCND3/SGK1/LPAR4/TSC1/LAMC3/COL9A1/PTEN/GRB2/IFNA1/IRS1/CD19/HSP90AB1/FGF16/MAGI1/ITGB6/TEK/MAGI2/HSP90AA1/STK11	61
KEGG	hsa04720	Long-term potentiation	10/1562	67/8135	0.8538	1	0.9009	ATF4/CALM2/RAPGEF3/CACNA1C/RPS6KA1/MAPK1/PRKACB/PPP1CA/GRIA2/EP300	10
KEGG	hsa00140	Steroid hormone biosynthesis	9/1562	61/8135	0.854	1	0.9009	CYP7B1/CYP3A5/HSD17B1/HSD17B7/HSD17B12/HSD11B1/SULT1E1/UGT2B7/UGT2B10	9
KEGG	hsa00590	Arachidonic acid metabolism	9/1562	61/8135	0.854	1	0.9009	PLA2G2D/CYP2C9/PTGES3/CBR1/CYP2C19/PLA2G5/EPHX2/PLA2G4C/CBR3	9
KEGG	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1562	79/8135	0.8549	1	0.9009	FGFR2/BCL2L11/AKT3/PLCG2/SHC3/PIK3CD/PIK3CA/MAPK1/ERBB2/PTEN/GRB2/NF1	12
KEGG	hsa01250	Biosynthesis of nucleotide sugars	5/1562	37/8135	0.8647	1	0.9009	GALE/NAGK/UGDH/FPGT/TGDS	5
KEGG	hsa00120	Primary bile acid biosynthesis	2/1562	17/8135	0.8659	1	0.9009	HSD17B4/CYP7B1	2
KEGG	hsa00450	Selenocompound metabolism	2/1562	17/8135	0.8659	1	0.9009	SEPHS2/TXNRD2	2
KEGG	hsa04977	Vitamin digestion and absorption	3/1562	24/8135	0.8668	1	0.9009	MMACHC/FOLH1/PNLIP	3
KEGG	hsa04261	Adrenergic signaling in cardiomyocytes	24/1562	150/8135	0.8676	1	0.9009	ATF4/CALM2/PPP2CA/CREB3L4/PPP2R2B/RAPGEF3/CACNG2/AKT3/PPP2R1A/CACNG8/PPP2R3B/ATP2B1/GNAI1/ATP1A1/CACNA1C/GNAS/ADRA1A/MAPK1/PRKACB/SCN7A/CACNA2D2/PPP1CA/ADCY2/ATP2B2	24
KEGG	hsa00510	N-Glycan biosynthesis	7/1562	50/8135	0.8706	1	0.9009	MGAT3/ST6GAL1/DAD1/FUT8/DPM3/ALG8/DPM2	7
KEGG	hsa05144	Malaria	7/1562	50/8135	0.8706	1	0.9009	TGFB3/TLR9/GYPA/CD81/HBA1/CD40/HBA2	7
KEGG	hsa04710	Circadian rhythm	4/1562	31/8135	0.8725	1	0.9009	PER1/CRY2/NPAS2/BHLHE40	4
KEGG	hsa04260	Cardiac muscle contraction	13/1562	87/8135	0.8774	1	0.9009	UQCRFS1/UQCR10/COX4I1/CACNG2/CACNG8/ATP1A1/CACNA1C/CYC1/COX7C/CACNA2D2/COX6B2/COX7A2L/TRDN	13
KEGG	hsa04270	Vascular smooth muscle contraction	21/1562	134/8135	0.8781	1	0.9009	PLA2G2D/GNA13/CALM2/PPP1R14A/MYH10/PPP1R12A/CACNA1C/ACTA2/GNAS/ADRA1A/MAPK1/PRKACB/ROCK2/KCNU1/PLA2G5/GNA12/PPP1CA/PLA2G4C/MYH11/ADCY2/PRKCD	21
KEGG	hsa04350	TGF-beta signaling pathway	14/1562	94/8135	0.8873	1	0.9009	SMAD9/TGFB3/PPP2CA/SMAD7/PPP2R1A/SMURF1/ID4/MAPK1/SMAD6/NODAL/SMAD3/SMAD2/EP300/GREM2	14
KEGG	hsa04971	Gastric acid secretion	11/1562	76/8135	0.8876	1	0.9009	CALM2/ACTG1/GNAI1/ATP1A1/CHRM3/GNAS/PRKACB/KCNE2/ADCY2/SSTR2/CA2	11
KEGG	hsa04916	Melanogenesis	15/1562	101/8135	0.8963	1	0.9009	CALM2/CREB3L4/GNAI1/CTNNB1/WNT11/WNT3/GNAS/MAPK1/WNT16/PRKACB/WNT6/ADCY2/FZD3/EP300/DCT	15
KEGG	hsa04725	Cholinergic synapse	17/1562	113/8135	0.8973	1	0.9009	ATF4/FOS/CREB3L4/CACNA1B/CACNA1A/AKT3/GNAI1/CACNA1C/PIK3CD/CHRM3/PIK3CA/MAPK1/PRKACB/CHRNA7/ADCY2/CHRNA6/KCNJ12	17
KEGG	hsa04927	Cortisol synthesis and secretion	9/1562	65/8135	0.9002	1	0.9009	ATF4/CREB3L4/CACNA1C/CACNA1G/GNAS/NR4A1/PRKACB/ADCY2/PBX1	9
KEGG	hsa00531	Glycosaminoglycan degradation	2/1562	19/8135	0.9043	1	0.9009	HYAL2/IDS	2
KEGG	hsa04973	Carbohydrate digestion and absorption	6/1562	47/8135	0.9107	1	0.9009	SLC37A4/AKT3/ATP1A1/PIK3CD/PIK3CA/SLC5A1	6
KEGG	hsa00040	Pentose and glucuronate interconversions	4/1562	34/8135	0.9144	1	0.9009	UGT2B7/UGDH/UGT2B10/RPE	4
KEGG	hsa04742	Taste transduction	12/1562	86/8135	0.9208	1	0.9009	PKD1L3/CACNA1A/CACNA1C/PKD2L1/CHRM3/PRKACB/TAS2R5/PDE1A/GABRA4/GABRA5/TRPM5/HTR3D	12
KEGG	hsa00983	Drug metabolism - other enzymes	11/1562	80/8135	0.9222	1	0.9009	DUT/NAT1/GSTM5/GSTT1/UGT2B7/XDH/CYP2A7/GSTA1/RRM2B/GSTM4/UGT2B10	11
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/1562	100/8135	0.9321	1	0.9009	IL6ST/CCR6/IL10RB/IL24/IL2RG/TNFSF10/IL2RA/CCL17/CXCR4/IL20RA/CCL16/IL10RA/XCL1/CCR9	14
KEGG	hsa00500	Starch and sucrose metabolism	4/1562	36/8135	0.935	1	0.9009	ENPP1/PGM2L1/GANC/AGL	4
KEGG	hsa04114	Oocyte meiosis	19/1562	131/8135	0.9357	1	0.9009	CALM2/ANAPC16/PPP2CA/ANAPC15/SMC1B/CPEB3/PPP2R1A/SPDYE6/CDC26/AURKA/SPDYE2B/RPS6KA1/MAPK1/PRKACB/PPP1CA/ANAPC7/CDC23/ADCY2/SMC1A	19
KEGG	hsa04650	Natural killer cell mediated cytotoxicity	19/1562	131/8135	0.9357	1	0.9009	RAC2/PTPN6/HLA-B/CD48/TNFSF10/PTK2B/ICAM2/PLCG2/SHC3/PIK3CD/PIK3CA/HLA-E/MAPK1/HLA-A/GRB2/IFNA1/NFATC2/VAV2/KIR3DL3	19
KEGG	hsa04630	JAK-STAT signaling pathway	24/1562	162/8135	0.9411	1	0.9009	CDKN1A/IL6ST/PTPN6/SOCS3/IL7/IL10RB/IL24/IL2RG/IL2RA/AKT3/STAT6/STAM2/IL20RA/CCND1/STAT5B/PIK3CD/PIK3CA/CCND3/IL10RA/GRB2/IFNA1/IL9R/STAT2/EP300	24
KEGG	hsa05143	African trypanosomiasis	4/1562	37/8135	0.9435	1	0.9009	TLR9/KNG1/HBA1/HBA2	4
KEGG	hsa03010	Ribosome	23/1562	158/8135	0.949	1	0.9009	MRPL18/MRPL35/MRPS5/MRPL1/RPS7/MRPS14/MRPS6/MRPS18C/RPS9/MRPL20/MRPL24/MRPS18A/MRPL3/MRPL34/RSL24D1/MRPL36/MRPS21/MRPS9/MRPL9/MRPL27/MRPS10/RPLP0/RPL36AL	23
KEGG	hsa04713	Circadian entrainment	13/1562	97/8135	0.9492	1	0.9009	PER1/FOS/CALM2/GNAI1/CACNA1C/MTNR1A/GRIA3/CACNA1G/GNAS/MAPK1/PRKACB/GRIA2/ADCY2	13
KEGG	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1562	14/8135	0.9496	1	0.9009	FUT8	1
KEGG	hsa00600	Sphingolipid metabolism	6/1562	52/8135	0.9512	1	0.9009	SGPP1/CERS6/SPHK2/CERS4/SMPD3/SMPD2	6
KEGG	hsa00052	Galactose metabolism	3/1562	31/8135	0.9536	1	0.9009	GALE/GANC/PFKL	3
KEGG	hsa00970	Aminoacyl-tRNA biosynthesis	8/1562	66/8135	0.9546	1	0.9009	FARSA/QRSL1/MTFMT/IARS2/TARS2/EARS2/FARSB/PARS2	8
KEGG	hsa04921	Oxytocin signaling pathway	22/1562	154/8135	0.9563	1	0.9009	CDKN1A/RGS2/FOS/CALM2/ACTG1/CACNG2/PPP1R12A/CACNG8/GNAI1/CCND1/CACNA1C/JUN/GNAS/MAPK1/PRKACB/ROCK2/CACNA2D2/PPP1CA/PLA2G4C/ADCY2/NFATC2/KCNJ12	22
KEGG	hsa04911	Insulin secretion	11/1562	86/8135	0.9569	1	0.9009	ATF4/CREB3L4/ATP1A1/CACNA1C/CHRM3/GNAS/PRKACB/KCNU1/FFAR1/PCLO/ADCY2	11
KEGG	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1562	15/8135	0.9593	1	0.9009	B3GALT4	1
KEGG	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1562	24/8135	0.96	1	0.9009	HS3ST1/EXTL2	2
KEGG	hsa04976	Bile secretion	11/1562	89/8135	0.9684	1	0.9009	ABCB11/ATP1A1/GNAS/UGT2B7/PRKACB/SLC4A5/ADCY2/ABCG2/CA2/SLC5A1/UGT2B10	11
KEGG	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1562	49/8135	0.9713	1	0.9009	CHIT1/GALE/NAGK/UGDH/FPGT	5
KEGG	hsa05206	MicroRNAs in cancer	47/1562	310/8135	0.9748	1	0.9009	CDKN1A/MIR150/IRS2/MIR103A2/TP63/MIR101-1/GLS2/EZH2/EFNA3/MIR32/BCL2L11/NFKB1/BMI1/HDAC1/MIR223/RASSF1/CCND1/HDAC2/PLCG2/MDM2/NOTCH4/MIRLET7D/WNT3/EFNA4/IKBKB/PIK3CD/SLC7A1/CRK/DDIT4/GLS/PIK3CA/NOTCH2/MAPK1/ERBB2/CD44/MIR215/MIR194-1/MIR128-2/MIR128-1/MIR19B2/PTEN/GRB2/IRS1/FZD3/MMP16/MIR210/EP300	47
KEGG	hsa04970	Salivary secretion	11/1562	93/8135	0.9795	1	0.9009	CALM2/ATP2B1/MUC7/ATP1A1/CHRM3/GNAS/ADRA1A/PRKACB/STATH/ADCY2/ATP2B2	11
KEGG	hsa04142	Lysosome	17/1562	132/8135	0.9798	1	0.9009	M6PR/MFSD8/HYAL2/AP4M1/CTNS/LAPTM4A/ACP5/AP1S1/NAPSA/LAPTM5/CTSC/CTSO/CLN5/NCOA7/GM2A/IDS/DNASE2	17
KEGG	hsa04540	Gap junction	10/1562	88/8135	0.9831	1	0.9009	TUBB2A/TUBB4A/TUBB2B/GNAI1/TUBB4B/GNAS/MAPK1/PRKACB/GRB2/ADCY2	10
KEGG	hsa05146	Amoebiasis	12/1562	102/8135	0.9842	1	0.9009	TGFB3/PRDX1/NFKB1/RAB5B/PIK3CD/GNAS/PIK3CA/PRKACB/RAB7A/LAMC3/RAB5C/ARG2	12
KEGG	hsa04924	Renin secretion	7/1562	69/8135	0.9865	1	0.9009	CALM2/PTGER4/GNAI1/CACNA1C/GNAS/PRKACB/PDE1A	7
KEGG	hsa04371	Apelin signaling pathway	17/1562	139/8135	0.9898	1	0.9009	GNA13/CALM2/KLF2/MEF2D/LIPE/AKT3/GNAI1/CCND1/MAP1LC3B/ACTA2/SPHK2/MAPK1/PRKACB/PPARGC1A/ADCY2/SMAD3/SMAD2	17
KEGG	hsa00515	Mannose type O-glycan biosynthesis	1/1562	23/8135	0.9926	1	0.9009	FKTN	1
KEGG	hsa04614	Renin-angiotensin system	1/1562	23/8135	0.9926	1	0.9009	KLK1	1
KEGG	hsa05171	Coronavirus disease - COVID-19	31/1562	232/8135	0.9932	1	0.9009	NFKBIA/IL6ST/FOS/OAS1/OAS2/NFKBIB/NFKB1/RPS7/DDX58/PLCG2/MX1/RPS9/MAPK8/JUN/IKBKB/PIK3CD/TMPRSS2/RSL24D1/TRAF6/PIK3CA/IRF3/MAPK1/CASP1/MAVS/IKBKE/IFNA1/C1R/RPLP0/MX2/STAT2/RPL36AL	31
KEGG	hsa05150	Staphylococcus aureus infection	10/1562	96/8135	0.9935	1	0.9009	HLA-DOB/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/FCGR2B/KRT10/HLA-DPB1/C1R/HLA-DQA1	10
KEGG	hsa04020	Calcium signaling pathway	31/1562	240/8135	0.9966	1	0.9009	CALM2/FGFR2/ERBB4/VDAC3/VDAC2/CACNA1B/CACNA1A/CXCR4/PTK2B/PPIF/ATP2B1/PLCG2/CACNA1C/SPHK2/CACNA1G/CHRM3/P2RX5/GNAS/ADRA1A/PRKACB/PHKB/ERBB2/PDE1A/CHRNA7/PLCE1/ORAI3/ADCY2/FGF16/ATP2B2/TRDN/TBXA2R	31
KEGG	hsa04613	Neutrophil extracellular trap formation	23/1562	190/8135	0.9969	1	0.9009	RAC2/CLCN3/VDAC3/HMGB1/VDAC2/CASP4/CYBA/ACTG1/NFKB1/AKT3/PPIF/HDAC1/HDAC2/PLCG2/NCF1/PIK3CD/PIK3CA/NCF4/MAPK1/CASP1/GSDMD/ATG7/HDAC9	23
KEGG	hsa00513	Various types of N-glycan biosynthesis	2/1562	39/8135	0.9975	1	0.9009	DAD1/FUT8	2
KEGG	hsa04610	Complement and coagulation cascades	6/1562	85/8135	0.9996	1	0.9009	CR2/CPB2/KNG1/A2M/C1R/PROCR	6
KEGG	hsa05034	Alcoholism	18/1562	187/8135	0.9999	1	0.9009	ATF4/CALM2/CREB3L4/HDAC1/GNAI1/HDAC2/SHC3/MAOB/FOSB/GNAS/PKIA/MAPK1/PRKACB/PPP1CA/MAOA/GRB2/NPY/HDAC9	18
KEGG	hsa05322	Systemic lupus erythematosus	11/1562	136/8135	0.9999	1	0.9009	SNRPB/HLA-DOB/SNRPD3/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DPA1/HLA-DPB1/C1R/CD40/HLA-DQA1	11
KEGG	hsa04060	Cytokine-cytokine receptor interaction	30/1562	295/8135	1	1	0.9009	IL6ST/IL16/CCR6/TGFB3/IL7/IL10RB/TNFRSF19/IL24/LTB/IL2RG/TNFSF10/IL2RA/CCL17/CXCR4/IL20RA/EDA2R/IL36B/BMP3/CCL16/NODAL/TNFSF18/IL1F10/IL10RA/XCL1/IL26/IFNA1/CCR9/CD40/IL9R/EBI3	30
KEGG	hsa04080	Neuroactive ligand-receptor interaction	38/1562	353/8135	1	1	0.9009	GABRG2/S1PR2/PTGER4/LYPD6B/TSHB/GABRB3/CGA/S1PR4/CALCR/GRIK2/CHRNA5/LHB/GABRB2/GNRH1/GRM3/MTNR1A/NPFFR2/P2RY14/GRIA3/RXFP1/CHRM3/P2RX5/ADRA1A/GALP/KNG1/CHRNA9/RXFP4/LPAR4/CHRNA7/GLRB/GRIA2/GABRA4/GABRA5/KISS1R/NPY/SSTR2/CHRNA6/TBXA2R	38
KEGG	hsa04740	Olfactory transduction	20/1562	440/8135	1	1	0.9009	RGS2/OR13C2/CALM2/OR8H2/OR10W1/OR5H6/OR13A1/OR13C5/PRKACB/OR2V1/OR52R1/PDE1A/OR6C75/OR10G3/OR2B11/OR52N5/OR4K2/OR8S1/OR13C9/OR51V1	20