RNAsnp is an efficient method to predict the effect of SNPs on local RNA secondary structure based on the RNA folding algorithms implemented in the Vienna RNA package.
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MutaRNA is a web server for visualization and interpretation of mutation-induced changes on the RNA structure in an intuitive and integrative fashion.
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LncCASE is a user-friendly web interface for exploring lncRNAs-CNV and their driving subpathways in various cancer types.
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PON-mt-tRNA is multifactorial probability-based prediction method which collect the mt-tRNA variations data and classify the classification of mt-tRNA single nucleotide substitutions.
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SNPfold can help identify the regulatory RNA in which a specific SNP has a structural consequence that results in a disease phenotype by leveraging GWAS data and an analysis of the mRNA structural ensemble. Unfortunately, this tool is not currently available.
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corRna is a web server for predicting the multiple-point deleterious mutations in structural RNAs.
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RNAmutants is a web server provides several efficient tools to compute the ensemble of low-energy secondary structures for all k-mutants of a given RNA sequence, where k is bounded by a user-specified upper bound. Unfortunately, this tool is not currently available.
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RDMAS web server is an online tool for evaluating structural deleteriousness of single nucleotide mutation in RNA genes. Unfortunately, this tool is not currently available.
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RNAmute is a structure based and relies on RNA secondary-structure prediction program for assisting in RNA mutational analysis. Unfortunately, this tool is not currently available.
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MultiRNAmute is a efficient addition to RNAmute that is as user friendly as the original application but that facilitates the practical analysis of multiple-point mutations is presented.
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RNAMute is a user friendly tool that can be used to predict single point mutations leading to conformational rearrangements in the secondary structure of RNAs.
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NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. Unfortunately, this tool is not currently available.
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INPS-MD (Impact of Non synonymous variations on Protein Stability-Multi-Dimension) is a web server for the prediction of protein stability changes upon single point variation from protein sequence and/or structure.
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mCSM is a web server, which relies on graph-based signatures to encode distance patterns between atoms to represent the protein residue environment and train predictive models for the study of missense mutations. Unfortunately, this tool is not currently available.
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DynaMut2 is a web server that combines Normal Mode Analysis (NMA) methods to capture protein motion and graph-based signatures to represent the wildtype environment to investigate the effects of single and multiple point mutations on protein stability and dynamics.
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mCSM-PPI2 is a novel machine learning computational tool designed to more accurately predict the effects of missense mutations on protein-protein interaction binding affinity.
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PhyreRisk is a web server designed to empower researchers to translate genetic data into protein structural information, thereby providing a more comprehensive appreciation of the functional impact of variants.
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mmCSM-PPI is a scalable and effective machine learning model for accurately assessing changes in protein-protein binding affinity caused by single and multiple missense mutations.
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SNP@Domain is a web resource to identify SNPs within human protein domains which will help scientists select and interpret SNPs associated with diseases. Unfortunately, this tool is not currently available.
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WS-SNPs&GO is a web server based on Support Vector Machines (SVM) and uses protein functional annotation to predict the deleterious Single Amino acid Polymorphisms (SAPs).
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StSNP is a web server which provides 'on the fly' comparative modeling of nsSNPs with links to metabolic pathway information, along with real-time visual comparative analysis of the modeled structures. Unfortunately, this tool is not currently available.
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SNP2Structure is a structure database resource which provides mapping of nsSNPs to 3D protein structures enabling researchers to explore the likely functional impact of human disease-causing mutations. Unfortunately, this tool is not currently available.
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STRUM is a web server for predicting stability change caused by single-point mutations, which demonstrates the feasibility to use low-resolution structure modeling for high-accuracy stability change prediction upon point mutations.
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GenProBiS is a web server that maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein-protein, protein-nucleic acid, protein-compound, and protein-metal ion binding sites.
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SNPs3D is a web resource and database that combines SNP impact analysis, knowledge based network of gene relationships, and candidate genes. SNPs3D provides and integrates as much information as possible on disease/gene relationships at the molecular level.
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mmCSM-NA is a web server combined with an optimized version of graph-based signatures and uses the first scalable method capable of quantitatively and accurately predicting the effects of multiple-point mutations on nucleic acid binding affinities.
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SuSPect (Disease-Susceptibility-based SAV Phenotype Prediction) is a web server for predicting how likely SAVs are to be associated with disease.
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visualCMAT is a web-server designed to assist experimental research in the fields of protein/enzyme biochemistry, protein engineering, and drug discovery by providing an intuitive and easy-to-use interface to the analysis of correlated mutations/co-evolving residues.
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IntSplice is a web server to predict splicing-affecting SNVs at intronic positions from -50 to -3.
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NLP-SNPPred is a web server to read scientific literature and learn the implicit features that cause certain variations to be pathogenic. Unfortunately, this tool is not currently available.
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