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Search for: rheumatoid arthritis    methotrexate    autoimmune disease    biomarker    gene expression    GWAS    HLA genes    non-HLA genes   

ID PMID Title PublicationDate abstract
1608603 [Stress proteins in medicine]. 1992 May 31 The stress, or heat-shock proteins are essential for the homeostasis of living cells. Their role in the intracellular transport, refolding, or elimination of proteins becomes especially important after any unusual stimuli (stress) of the cell. This central role explains why stress proteins represent one of the most conservative structures of living cells. Human and bacterial stress proteins also show a homology as high, as 50%. This structural similarity links the immune responses against bacterial infections with a number of autoimmune diseases, such as lupus erythematosus, rheumatoid arthritis and insulin dependent diabetes mellitus, IDDM. In the end of our review we also discuss the possible role of stress proteins in protection against cardiac ischaemia and their putative role in aging.
20429989 [Antibodies to Collagen in the Patients with primary Operation and Reoperation of Endopros 1992 Using ELISA method titres were determined of antibodies to collagen of type I, II and III in the serum of the patients who underwent implantation or reoperation of total endoprosthesis of the hip joint. The group of primary operations included mainly patients with osteoarthritis (OA), ankylosing spondyllitistis (AS), rheumatoid arthritis (RA), the group of the reoperated comprised also patients after various traumas of the hip joint. Increased titres were generally found in all patients, however, in the group of reoperated patients the average values were higher than in the patients after primary operations. In the reoperated patients the level of antibodies against all types of collagen monitored was statistically significantly increased in comparison with the control group both prior to and after the surgical operation, mainly in type II. The patients before the primary operation have the levels of antibodies against collagen type II significantly increased in comparison with the controls. The increase found may be caused by the primary articular disease - inflammatory changes, which were found also in decompensated OA. Key words: hip joint replacement, reoperation, collagen, antibodies.
8902772 The catastrophic antiphospholipid syndrome 1996: acute multi-organ failure associated with 1996 Oct Thirty one patients with antiphospholipid antibodies who developed multi-organ failure ("Catastrophic Antiphospholipid Syndrome") are reviewed. Thirteen suffered from a 'Primary' antiphospholipid syndrome, 13 from defined SLE, 4 from 'lupus-like' disease and one from rheumatoid arthritis. In more than one third precipitating factors were evident (e.g. infections, major/minor surgical procedures, oral contraceptives). Death occurred in 60% of patients from a variety of causes (myocardial failure, ARDS, CNS causes or, often a combination). Disseminated Intravascular Coagulation was present in 8 of 31 patients. Plasmapheresis appeared to be useful in several who had not responded to conventional therapy (e.g. IV heparin, steroids, immunosuppression).
7645110 [Methotrexate treatment of patients with prednisolone dependent bronchial asthma]. 1995 Aug 21 In this review we went through eight placebo-controlled clinical trials of the folic acid antagonist methotrexate in the treatment of bronchial asthma. The studies, which differ in their methods and findings, are reviewed critically. Some studies seem to give documentation of methotrexate as an effective drug in reducing the corticosteroid requirements in patients with chronic corticosteroid-dependent asthma. Adverse effects are wellknown from the use of methotrexate in patients with rheumatoid arthritis and include nausea, diarrhoea, vomiting, transient increases in liver enzymes, alopecia and stomatitis. Rare but potentially life-threatening adverse effects are interstitial pneumonitis, opportunistic infections, bone marrow- and renal insufficiency. The role of methotrexate in patients with chronic corticosteroid-dependent asthma still needs to be clarified. Practical guide-lines in treating asthma patients with methotrexate are suggested.
7787700 [The pharmacokinetics of the new Russian prolonged-action form of diclofenac sodium--Ortop 1995 Jan Ortopak tablets, 100 mg, were investigated. The pharmacokinetics of Ortopak was studied in 10 rheumatoid arthritis patients after a single oral dose of 100 mg. Ortophenum and voltaren-retard (Ciba-Geigy) were used for comparison. Diclophenac-sodium was measured in the patient's plasma by using high performance liquid chromatography. Ortopak was shown to be eliminated from the patient's body much slower than Ortophenum. The bioequivalence of Ortopak versus Ortophenum was 62.7%. The pharmacokinetic properties of Ortopak were similar to those of Voltaren-retard, which were close to those of diclophenac-sodium in the blood plasma within the therapeutic range.
7587634 Treatment of inflammatory diseases with a monoclonal antibody to intercellular adhesion mo 1995 A mouse monoclonal antibody to intercellular adhesion molecule 1 (ICAM-1) has been evaluated in multiple animal models of inflammation as well as in the clinic. Anti-ICAM-1 has been found to protect against allograft rejection and ischaemia/reperfusion injury in non-human primates and rabbits. In open-label phase I-II studies, anti-ICAM-1 appears to have prolonged kidney allograft survival when used as induction therapy in conjunction with traditional triple immunosuppressive therapy. Anti-ICAM-1 has shown beneficial effects in the treatment of rheumatoid arthritis when given for five days. Most patients receiving anti-ICAM-1 made antibodies to the mouse immunoglobulin.
7932345 The role of computerized tomography in shoulder arthrography. 1994 Jun Double contrast computerized tomographic (CT) shoulder arthrograms of 55 shoulders were reviewed. This investigation was compared with conventional arthrograms and the findings were correlated with subsequent clinical and surgical follow-up. CT arthrograms were found to be useful in demonstrating bony, ligamentous and cartilaginous structures and have helped the surgeon in deciding the approach and type of surgical procedure. Indications for CT arthrography are recurrent dislocation, multidirectional instability, severe rheumatoid arthritis and other arthritides, complex shoulder deformities and suspected loose bodies. We found that this examination was not as helpful for rotator cuff injuries, impingement syndrome, adhesive capsulitis and in cases of vague or mild shoulder pain.
8049699 Molecular bases for human leucocyte elastase inhibition. 1994 Apr Human leucocyte elastase is a serine proteinase involved in phagocytosis, defence against invading micro-organisms, degradation of elastin, collagen, proteoglycans, fibrinogen and fibrin, being also responsible for the digestion of damaged tissues and of the bacterial degradation products. Lack of the enzyme regulation is at the basis of pathological states, such as pulmonary emphysema, cystic fibrosis, rheumatoid arthritis, atherosclerosis and glomerulonephritis. A detailed characterisation of the enzyme:inhibitor recognition process, based on extensive thermodynamic, kinetic and structural information, as well as on the comparative analysis with the homologous proteinase from porcine pancreas, is reported in the present review.
8302491 Vitamin B6 and immune competence. 1993 Aug Animal and human studies suggest that vitamin B6 deficiency affects both humoral and cell-mediated immune responses. Lymphocyte differentiation and maturation are altered by deficiency, delayed-type hypersensitivity responses are reduced, and antibody production may be indirectly impaired. Although repletion of the vitamin restores these functions, megadoses do not produce benefits beyond those observed with moderate supplementation. Additional human studies indicate that vitamin B6 status may influence tumor growth and disease processes. Deficiency of the vitamin has been associated with immunological changes observed in the elderly, persons infected with human immunodeficiency virus (HIV), and those with uremia or rheumatoid arthritis. Future research efforts should focus on establishing the mechanism underlying the effects of vitamin B6 on immunity and should attempt to establish safe intake levels that optimize immune response.
8230029 Myasthenia gravis and scleroderma. 1993 Aug Myasthenia gravis is an autoimmune disease that is associated with antibodies to acetylcholine receptors. It is associated with other autoimmune diseases such as thyroiditis (10%), systemic lupus erythematosus (2-8%), rheumatoid arthritis (4-7%), Sjögren's syndrome and polymyositis. It is not commonly found with scleroderma. We describe a case of scleroderma developing in a patient 6 years after the onset of myasthenia gravis. HLA-B8/DR3 may play a role in the association of the 2 conditions.
8501366 The use of ultrasonography in detection of synovitis in carpal tunnel syndrome. 1993 Apr The findings of pre-operative ultrasonography of the carpal tunnel were compared with synovial histology in 50 surgically treated wrists with carpal tunnel syndrome. Eight wrists with a massive hypoechoic area (group 3) had synovitis. 28 with a minimal hypoechoic area (group 1) had no evidence of inflammation. 14 with a moderately increased hypoechoic area (group 2) consisted of three with synovitis, four with lymphocytic infiltration and seven without inflammation. Group 3 strongly indicates synovitis, in which case one should consider aetiology other than the idiopathic cause. Bilateral synovial thickening suggests carpal tunnel syndrome as the initial clinical picture of rheumatoid arthritis, and group 1 indicates idiopathic carpal tunnel syndrome provided that there are no primary causes.
8477406 Pharmacological basis of immunotherapy in autoimmune diseases. 1993 Apr The clinical development of immunomodulatory agents for the treatment of autoimmune diseases is an arduous process. This can be explained by the fact that the true pathogenic mechanism of the disease(s) is unknown. Moreover, the properties and pharmacokinetic profile of these immunomodulatory agents are different from other classic therapeutic compounds. The aim of this brief review is to discuss a number of general aspects of the clinical pharmacology of i.v. immune globulin as well as more recent immunotherapeutic approaches such as anti-cytokine therapy, which are currently being applied in the immunotherapy for neurologic and rheumatic autoimmune disorders such as myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and rheumatoid arthritis. A better understanding of the interaction of the therapeutic compound and the host immune response, the knowledge of its kinetic profile, and the development of surrogate markers of clinical efficacy should help in designing randomized and blinded clinical trials that will ultimately determine the optimal therapeutic regimen.
8453317 Methotrexate pneumonitis in bronchial asthma. 1993 Methotrexate pneumonitis is one of the most unpredictable and potentially serious adverse effects associated with the use of low-dose pulse methotrexate in treating rheumatoid arthritis. However, its occurrence in treating bronchial asthma has never been reported. A patient with steroid-dependent bronchial asthma developed interstitial pneumonitis during methotrexate therapy. Dyspnea, fever and oral ulcer occurred successively during the initial 4 months of intermittent low-dose methotrexate pulse therapy. Despite severe hypoxemia and interstitial infiltration in both lung fields, the lung lesions disappeared after treatment with corticosteroid and discontinuation of methotrexate therapy. In conclusion, methotrexate pneumonitis might develop after treatment. Once pneumonitis is suspected, methotrexate should be withdrawn.
8296671 Lactoferrin, anti-lactoferrin antibodies and inflammatory disease. 1993 The nucleophilic properties of human lactoferrin (Lf) were demonstrated by immunofluorescence microscopy using cryostat rat tissue sections, and the nuclear/perinuclear distribution of Lf in ethanol-fixed human neutrophils was visualized with rabbit anti-human Lf, producing a P-ANCA/GS-ANA staining pattern. Prevention of complement activation by Lf was confirmed in a haemolytic assay. Antibodies (IgG) against human Lf were studied by ELISA in sera from patients with Crohn's disease, ulcerative colitis, primary sclerosing cholangitis, rheumatoid arthritis, systemic lupus erythematous and primary Sjögren's syndrome. Anti-Lf antibodies were found in high frequency in ulcerative colitis and primary sclerosing cholangitis, but only occasionally in the other conditions.
1480970 [Treatment of aseptic post-traumatic pseudarthrosis]. 1992 Nov We report our first experience of using the Ilisarov technique in the treatment of ten patients with aseptic nonunions of fractures. In nine cases there was a nonunion of the tibia. One 76-year-old woman suffered from a nonunion of a supracondylar fracture of the humerus with concomitant rheumatoid arthritis. In this case, treatment failed. In two other cases we had to change the procedure. The mean duration of fixation for the successful cases was 22 weeks. The Ilisarov technique is sophisticated and needs special experience but has advantages in difficult cases.
1340948 [Severe hemorrhagic syndrome secondary to active circulating inhibitors of the intrinsic p 1992 Nov The study of three adults with severe bleeding due to the presence of acquired anticoagulants that inhibit procoagulant action of Factor VIII and to a lesser degree of factors IX and XI, is described. In one case, this phenomenon occurred during the course of a rheumatoid arthritis, in one case coincided with a megaloblastic anemia (pernicious anemia) and the last case did not have any coexisting disease. Corticosteroids were useless, intravenous cyclophosphamide improved one patient and given orally failed in other patient. The circulating inhibitor disappeared in the patient successfully treated with cyclophosphamide and persisted and was the cause of death in the other two patients. In one patient, column fractioning demonstrated that the anticoagulant was an G immunoglobulin, with higher activity at pH 6.5.
1624073 Gm and Km allotypes in autoimmune diseases. 1992 Jan The associations or linkages between the polymorphisms of the Gm and Km immunoglobulin allotypes and the susceptibility to autoimmune diseases, including diseases with immuno-pathological pathogenesis are reported in this review. These diseases include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, insulin-dependent diabetes mellitus, Crohn's disease, coeliac disease, Graves' disease, atrophic thyroiditis, Hashimoto's thyroiditis, myasthenia gravis, chronic active hepatitis, alopecia areata, uveitis, vitiligo, Turner's syndrome, glomerular nephritis, Berger's disease and idiopathic dilated cardiomyopathy. Immunoglobulin allotypes are described as well as the statistical methods used to analyse the data.
1598769 [Nerve compression syndrome caused by synovial cyst of the hip joint]. 1992 Mar Synovitis of the iliopectineal bursa have been described in pigmented villanodular synovitis, synovial chondromatosis, rheumatoid arthritis, osteoarthritis and necrosis of the femoral head. We report a case of enlargement of such a cyst in necrosis of femoral head and consecutive osteoarthritis, leading to entrapment of the femoral nerve. Simple drainage of the cyst did resolve pain for a short period and only elimination of the primum pathologicum agens did definitively release pain, irradiating to the ipsilateral leg.
9041730 [Noncardiogenic pulmonary edema associated with hydrochlorothiazide use]. 1996 Jun A 54 years old female patient with a mitral valve prolapse and a rheumatoid arthritis treated with steroids was admitted with dyspnea and hypotension, that started 30 min after taking a pill containing enapril and hydrochlorothiazide. Hemodynamic monitoring with a Swan-Ganz catheter showed a pulmonary capillary pressure of 5 mm Hg, a systemic vascular resistance of 887 (dyn sec)/cm5 and a cardiac output of 10 l/min. The patient had a history of adverse reactions to thiazides and responded to volume replacement, dopamine and steroids.
8728288 [Extracellular matrix components and angiogenesis]. 1996 Mar Angiogenesis, the formation of new capillaries, is critical for normal physiological processes such as embryonic development and wound repair. However, it also facilitates pathological processes including tumor growth, metastases, proliferative diabetic retinopathy and pannus formation in rheumatoid arthritis. It has been described that the angiogenesis occurs through a series of events that include endothelial cell protease production, migration and proliferation, tubule formation, and basement membrane incorporation. Within the last two decades, with in vivo assay systems, various kinds of growth factors were identified as angiogenic factors that promote endothelial cell proliferation and migration, while an in vitro model for angiogenesis indicated that extracellular matrix (ECM) proteins stimulated endothelial cells to organize into a capillary-like tubular network and suggested that the ECM proteins are involved in the tubule formation process of antiogenesis. Recent papers reported the identification of the specific receptors on endothelial cells involved in the ECM-induced capillary tube formation. This article will focus on papers describing the in vitro analyses of tube formation of endothelial cells.