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ID PMID Title PublicationDate abstract
9417658 [Are life experiences of children significant for the development of somatic disease? A li 1997 Oct 20 This review presents the relationship between serious life events, chronic family difficulties and illness, and focuses on how healthy children cope. Hospitalised children had experienced about twice as many serious life events as children in healthy environments. Known diseases related to stress are eczema, upper respiratory tract infections, asthma, ulcerative colitis, heart disease in adults, juvenile rheumatoid arthritis, fibromyalgia and juvenile diabetes. Research on healthy children at risk (resiliences) has revealed a number of social and interpersonal protective factors. A modified biopsychosocial model, for the purpose of understanding the health status and care of children at high risk, is presented. More research is needed to understand these multietiological diseases in order to develop strategies for the promotion of good health.
11924399 [Success of implants in the moderately resorbed edentate maxilla]. 1997 Jul In applications of implants in the moderately resorbed maxilla factors such as bone quantity and the loading of the bone are of importance for the prognosis. Long-term studies have shown that for the maxilla the results were less good than for the mandible. The main reason for this is the condition of the bone, especially reduced bone quantity together with a thin corticalis an low bone density. Beside these factors there are also the general negative factors such as rheumatoid arthritis, osteoporosis, smoking and radiotherapy. The prognosis of implant supported prostheses is not primarily determined by the number of implants, but by the condition of the bone and to some extent by the splinting effect of the implants.
9180962 [The HLA system: a clinical help?]. 1997 Mar Chronic diseases are polymorph and influenced by many environmental and genetic factors. The HLA system is implicated in the modulation the onset and the evolution of chronic diseases. These observations are important to be considered for the prediction, prognosis and treatment adaptation. Evaluation tests are mainly statistical and are based on epidemiological studies. Thus, results must be considered with caution. Two aspects are to be considered: DIAGNOSIS: Associations between HLA alleles and chronic diseases are well known but concern very few diseases like narcolepsy or rheumatoid arthritis. Insulin dependent diabetes mellitus is particular because the prediction is limited to familial studies. PROGNOSIS: This point is less documented in clinical applications but is of interest particularly in inflammatory bowel diseases or systemic affections. This observation can be considered as a compartmental response which is a kind of adaptation to stress.
10832164 [Whole-body cryotherapy in rehabilitation of patients with rheumatoid diseases--pilot stud 2000 Apr Cryotherapy as a whole-body cold therapy (with cold air cooled by addition of nitrogen blown on the patients in an open cabin) for treatment of inflammatory rheumatic diseases already started in Bad Säckingen in 1986. In 1996, a new cold chamber (this time a closed chamber without any addition of nitrogen) based on compressor technology was introduced. The aim of our study was to test whether significant pain relief could be achieved by means of this cold therapy. Furthermore, we were interested in the practicability and acceptance of this new technique. Wellbeing during the treatment application and pain level were assessed using verbal and numerical rating scales. The sample consisted of 120 consecutive patients (75% women, age: 30-67 yrs, M = 52.6 yrs). These patients were suffering from primary fibromyalgia (40.7%), rheumatoid arthritis (17.3%), chronic low back pain (16.4%), ankylosing spondylitis (10.9%), osteoarthritis (9.1%), secondary fibromyalgia (3.6%) and other autoimmune diseases (1.8%) (mean duration of symptoms: 4 yrs). The patients were treated 2.5 minutes on average in the main chamber (mean temperature: -105 degrees C). The patients' statements concerning their pain level were analyzed by means of analyses of variance with repeated measures and paired-sample t-tests. RESULTS: The pain level after application of the cold therapy decreases significantly. The pain reduction lasts about 90 minutes. The initial pain level decreases during the whole time of treatment, no significant improvement, though, can be shown from the middle to the end of the four-weeks treatment. According to the results of our study, there is evidence that the whole-body cold therapy generates important short-term effects and somewhat weaker effects over the treatment period as a whole. Short-term pain reduction facilitates intensive application of physiotherapy and Occupational Therapy. The treatment procedure is practicable, and all in all well tolerated. From the patients' point of view, whole-body cold therapy is an essential part of the rehabilitation programme.
15992019 The therapeutic potential of anti-cytokine antibodies in the treatment of chronic inflamma 1998 Jul The outcome of inflammatory diseases is likely to be dependent upon the relative balance of pro- versus anti-inflammatory cytokines. Control of this balance through the use of anti-cytokine monoclonal antibodies (mAbs) promises to be an effective means of disease therapy. The treatment of rheumatoid arthritis (RA) or inflammatory bowel disease (IBD) with anti- tumour necrosis factor alpha (TNF-alpha) mAb has dramatically ameliorated disease symptoms, indicating that such a treatment approach can be highly successful. Similarly, based on animal studies, the use of neutralising anti-interleukin (IL)-12 mAb may prove efficacious in a number of inflammatory disorders, particularly for IBD.
12879104 Lornoxicam, a new potent NSAID with an improved tolerability profile. 2000 Jan Lornoxicam is a member of the oxicam group of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams have potent antiinflammatory and analgesic effects, but their use is associated with a high risk of gastrointestinal adverse effects. Lornoxicam has been shown to be at least as effective as comparative NSAIDs and more effective than 10 mg morphine when used at doses > or = 8 mg to control pain after oral surgery. In addition, oral doses of lornoxicam of 16-24 mg daily have been more effective than tramadol 300 mg daily in pain following knee surgery. Lornoxicam combines the high therapeutic potency of oxicams with an improved gastrointestinal toxicity profile as compared to naproxen, for example. This is probably due to the short half-life of lornoxicam as compared to the other oxicams. The clinical trials published so far, mostly comparative, clearly do- cument the efficacy of lornoxicam as a potent analgesic with excellent antiinflammatory properties in a range of painful and/or inflammatory conditions, including postoperative pain and rheumatoid arthritis.
11578009 Rheumatic diseases and malignancy--is there an association? 2001 An association between rheumatic diseases and malignancy has been claimed in a variety of settings. This editorial reviews published data addressing the overall risk of malignancy, and of particular types of cancer, in the context of various autoimmune rheumatic diseases. For patients with Sjögren's syndrome, systemic sclerosis with pulmonary fibrosis, or with dermatomyositis/polymyositis there is a documented association with an increased risk of malignant disease. Patients with rheumatoid arthritis may also have an increased risk of cancer. It is still controversial whether systemic lupus erythematosus is associated with an increased risk of developing malignancy. More epidemiologic studies are needed to try and clarify many of these associations, in particular the potential risks associated with cytotoxic therapy.
11552335 [Autoimmune cholangiopathy]. 2001 May We report two patients with mixed characteristics of primary biliary cirrhosis and autoimmune hepatitis. They are two female patients in their fifties (54 and 58 years-old) one of them with autoimmune phenomenon, rheumatoid arthritis and Sjögren syndrome. Both of them showed laboratory values of cholestasis and the liver biopsy revealed liver cirrhosis with significant lesions of the bile ducts. They were treated with prednisolone with a rapid improvement and normalisation of their blood tests. They belong to a group called as overlap syndrome or autoimmune cholangitis with mixed characteristics, clinical, biochemical, immunological, and histopathologic overlapping between primary biliary cirrhosis and autoimmune hepatitis type I.
11542870 From growing plants to killing tumors. 2000 Apr
11230461 Case of synovitis potentially caused by Dolosigranulum pigrum. 2001 Mar We report a case of synovitis in a 64-year-old man who developed the infection while on steroid therapy for rheumatoid arthritis. Dolosigranulum pigrum, a gram-positive catalase-negative coccus, was isolated from two sets of blood cultures prior to antibiotic therapy. The patient was treated with 4 weeks of appropriate antibiotics, and the synovial inflammation resolved. Although synovial aspirates were never positive for any bacteria or fungi, the timing of positive blood cultures and absence of other pathogens suggest the possible etiology as D. pigrum.
11092801 The psychology of rheumatic diseases. 2000 Dec Most chronic rheumatological disorders require major psychological adaptation, and levels of psychological distress among those with rheumatological disease have been found to be higher than in the general population. Research suggests that the relationship between disease severity, disablement and psychological well-being is not simple. This chapter highlights the complex nature of this relationship and will indicate, in particular, how psychological factors can impact on patients' perceptions of their symptoms and physical functioning. Psychological concepts that may mediate between the disease and its consequences are also discussed. A range of psychosocial interventions have been developed for individuals with rheumatological disorders. Most have related to rheumatoid arthritis, and although their primary focus has usually been on alleviating pain and improving physical functioning, this chapter examines their impact on psychological well-being. It also discusses a number of methodological issues that need to be addressed in this area of work.
10790752 Microglia dysfunction in schizophrenia: an integrative theory. 2000 Feb Schizophrenia is a devastating illness of unknown etiology. It is characterized by increased brain ventricular volume, suggesting a progressive neurodevelopmental condition. There is evidence suggesting a correlation between in utero viral exposure and subsequent occurrence of schizophrenia. Many neurotransmitter systems have been implicated as being dysfunctional in schizophrenia. There are also data suggesting immune system dysfunction in schizophrenia, and a negative correlation between schizophrenia and rheumatoid arthritis. Microglia are phagocytic immune cells in the central nervous system (CNS) derived from peripheral blood monocytes. They are involved in brain development, neuroproliferative and neurodegenerative activities, several CNS illnesses, and CNS viral immunity. They may also be involved in neurotransmitter regulation. The current theory postulates microglial dysfunction initiated by early CNS viral exposure results in the abnormal neural development and neurotransmitter dysfunction seen in schizophrenia.
10207318 [Clinical picture of pure corneal ulcers of different localizations]. 1999 Jan Pure corneal ulcers can be localized at the periphery and in the center. Peripheral ulcers are bilateral in 66% and multifocal in 48% cases. They are combined with local vasculitis of perilimbic vessels of the conjunctiva. In 84% cases the disease occurred in patients with connective tissue and articular diseases. Clinical picture of the peripheral corneal ulcer differs from Mourene's phagodenic ulcer. Central corneal ulcers are bilateral in 40% patients, are associated with primary and secondary "dry eye" syndrome in Sjogren's disease, rheumatoid arthritis, systemic vasculitis, Behçet's disease, and in 18% patients with cicatricial deformation of the conjunctiva after Stevens-Johnson's syndrome, trachoma, and chemical burns of the eyes. Pure corneal ulcers run a chronic relapsing course, complicated in one-fourth of patients by corneal perforation and secondary infections.
10091307 [Status of problems with administration of hormonal contraceptives]. 1999 Following the application of oral hormonal contraceptives situations may occur which need fast clarification. In this report we discuss the practical aspects of forgetting to take hormonal contraceptives, the risk for birth defects, the time when to restart taking oral contraceptives after delivery and abortion, the indications for stopping the application, the taking of oral contraceptives under anticoagulant therapy, the behaviour during migraine, the raising need of ethinylestradiol in the case of epilepsy, the procedure in case of oligophrenia, the prevention of the rheumatoid arthritis as well as special questions in cases of diabetes mellitus and gestational diabetes.
9987959 [Genetic aspects of rheumatic diseases]. 1998 The paper presents the results of the long-term studies of the pattern of hereditary predisposition to rheumatism, rheumatoid arthritis (RA), ankylosing spondyloarthritis (AS), osteoarthrosis which have been conducted at the Institute of Rheumatology, Russian Academy of Medical Sciences. It gives data on the type of inheritance of these diseases, the affliction heritability ratio, the penetrance of three genotypes within the model of an autosomal one-allele locus (SAL-2) for rheumatism and RA. The contribution of additive and dominant components in the determination of rheumatism and RA, the results of tests of their genetic heterogeneity, associations with HLA antigens are assessed. The paper outlines the results of tests of the candidate genes COLIA2, TCRB, TCRD as major RA predisposition genes via analysis of adherence and DNA polymorphism.
9621888 Patellar tendon rupture in five deer. 1998 Jun 1 Acute unilateral or bilateral rupture of the patellar tendon was diagnosed in 5 aged obese female Pere David's deer housed at a zoological park. Rupture occurred after an episode of sudden exertion in 4 of 5 deer. Fragmentation, degeneration, necrosis, and mineralization of ruptured patellar tendon fibers were found on histologic examination. Similar changes were often seen in intact contralateral tendons that did not have gross lesions. Patellar tendon rupture in humans is associated with concurrent systemic disease, such as systemic lupus erythematosus, rheumatoid arthritis, or chronic renal failure. Without evidence of underlying systemic disease, spontaneous patellar tendon rupture in deer can be considered a sequela to age-related tendinous degeneration compounded by sudden exertion and chronic overload attributable to obesity.
10178626 Cataracts in systemic diseases and syndromes. 1998 Feb This review attempts to interpret the basic science and more esoteric aspects of diseases associated with cataract, in the context of practical management and diagnostic implications. In the past year, the large epidemiologic Beaver Dam Eye Study has dismissed many putative relationships between cataract and cardiovascular risk factors. However, glycated hemoglobin and high density lipoprotein cholesterol levels still have an association. Cataract continues to be associated with a number of systemic diseases and syndromes such as atherosclerosis, diabetes mellitus, atopy, juvenile rheumatoid arthritis, Marfan's syndrome, and the Cronkhite-Canada syndrome. The unifying role of oxidative stress in the formation of these, as well as iatrogenically induced laser cataracts, is presented, together with a biochemical update on the pathogenesis. Finally, to bridge the gap between the basic science and clinical significance, recent controversial and practical management issues have been highlighted.
9159545 Rheumatology out-patient workload increases inexorably. 1997 Apr Rheumatology out-patient consultations in the south-west of England from 1 to 30 November 1994 were recorded by standard methods and compared to 1988, 1990, 1991 and 1992. Historical records at one centre provided additional detailed information. There has been an overall increase of 31% in the number of patients seen (30% for follow-up cases, 36% for new referrals), but the mean waiting time for new patient consultations increased from 65 to 108 days. The proportion of new patient consultations with non-arthritic diseases increased by 8.2%, and those with rheumatoid arthritis and polyarthritis decreased by 9.0%. Variation in discharge rates and length of follow-up appointments occurred, but mostly in uncommon diagnostic categories. Referral rates have been rising faster since the introduction of National Health Service reforms than can be accommodated by the increased workload undertaken.
10168274 Pediatric cataracts. 1997 Feb Posterior chamber intraocular lenses are a well-accepted treatment of aphakia in children 2 years of age and older, with many now considering them as the treatment of choice. Infants, however, are usually treated with contact lens, rather than intraocular lens implantation, as the infant eye undergoes significant axial elongation. The use of intraocular lenses in children with cataracts associated with juvenile rheumatoid arthritis remains controversial, but a recent article [9] describes good results in these patients, who historically have a poor prognosis. The management of amblyopia associated with unilateral congenital cataracts is evolving. In the 1970s and 1980s, full-time occlusion of the sound eye was advocated for infants with unilateral congenital cataracts. It was also taught that binocular fusion was impossible to obtain, and children with unilateral cataracts inevitably develop strabismus. Recent studies have shown that part-time occlusion may in fact yield better results, allowing the development of binocular vision and stereopsis and reducing the incidence of strabismus.
9538401 [ANCA (antineutrophil cytoplasmic antibodies). Contribution of ANCA to the understanding o 1997 ANCA (antineutrophil cytoplasmic antibodies) are a growing class of interest; these antibodies target lysosomial enzymes from polymorphonuclear cells. They represent diagnosis tools and prognosis markers in systemic vasculitis (Wegener's granulomatosis and microscopic polyangiitis). They are also detected in other chronic inflammatory diseases as lupus and rheumatoid arthritis. Their description, ten years ago, led to a huge amount of clinical and experimental work. The role of ANCA as pathogenic auto-antibodies in the disease is supported in numerous studies giving new insights into the pathogenesis of systemic vasculitis.