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ID PMID Title PublicationDate abstract
11554071 [A case of primary lung adenocarcinoma with diffuse calcification in the tumor by psamoma 2001 Sep A 78-year-old asymptomatic woman was referred to our department for the treatment of a right lung tumor. The patient had been suffering from rheumatoid arthritis and followed up in outpatient clinic. On March 6, 1995, abnormal shadow in the right upper lobe was pointed out by routine chest X-ray. Chest CT revealed calcification in the shadow, and benign lesion, such as old pulmonary tuberculosis, was suspected. During follow-up, the size of the shadow and calcification area in the shadow gradually increased. Malignancy was suspected based on the increasing size of the tumor. On July 12, 2000, video-assisted right upper lobectomy with hilar and mediastinal lymph node sampling was performed. Pathological examination revealed that the tumor was primary lung adenocarcinoma containing psamoma bodies in the tumor.
11051789 [A novel monocyte chemotactic factor that connects innate immunity and acquired immunity]. 2000 Jul A monocyte chemotactic factor was separated from rheumatoid arthritis synovium, and identified as a homo-dimer of S19 ribosomal protein. When S19 protein was treated with the plasma transglutaminase, an inter-molecular isopeptide bond was formed between Lys122 and Gln137, and the chemotactic activity appeared. The S19 protein dimer caused chemotaxis via the receptor on monocytes to C5a, the complement C5-derived chemotactic factor. This dimer antagonized the C5a receptor on neutrophils. This dimer was released from apoptotic cells, and functioned in the phagocytic clearance of these cells by recruiting circulating monocytes. After engulfment, the macrophages moved to regional lymph nodes, and presented apoptotic cell-derived antigens to T cells. T cells proliferated and activated B cells, and eventually the IgM antibody response was observed. Cooperation between the innate immune response and the acquired response would induce an effective host defense primarily against viral infection.
10862391 Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome: a review 2000 May Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a disease that commonly produces symmetrical synovitis and swelling of both the upper and lower extremities. It generally involves the wrists, hands, feet, and ankles of the affected individual. This syndrome most often resembles that of polymyalgia rheumatica and rheumatoid arthritis and usually affects elderly Caucasian males. Serological testing is typically negative except for a mild to moderate elevation of the erythrocyte sedimentation rate. The HLA-B7 phenotype is present in approximately 50% of patients with this syndrome. Treatment of RS3PE syndrome is heralded by the predictable response to low-dose corticosteroid or hydroxychloroquine therapy. There has been no previous mention of this condition in the podiatric literature. Presented below is a review of this syndrome and three case studies.
10847975 Rotatory motion of a cemented acetabular component caused by aseptic loosening and dissoci 1999 A 63-year-old woman without rheumatoid arthritis who had undergone cemented total hip arthroplasty developed coxalgia 1 year later. Radiography showed a clear zone at the cement-implant interface and rotatory motion of the acetabular component, so revision surgery was performed 4.5 years after the first operation. Aseptic loosening was noted and 7 spacers outside the acetabular component were broken and buried under the cement mantle. We consider that the rotatory motion may be caused by circumferential loosening of the acetabular component stemming from incomplete implant fixation and also dissociation of the ultra-high-molecular weight polyethylene (UHMWPE) liner from the metal base plate.
10818609 Detection of DNA in the plasma of septic patients. 2000 Apr Small amounts of plasma-free DNA have been observed both in healthy individuals and in patients with various diseases such as systemic lupus erythematosus, rheumatoid arthritis, viral hepatitis, and cancer. This communication demonstrates that septic patients also release DNA in plasma. After DNA extraction from plasma, exon 1 of the K-ras gene was amplified by PCR and products were analyzed by dot-blot hybridization. Plasmas from polytraumatic patients and control healthy individuals were used for comparisons with septic patients. Our results show that septic patients present DNA in their plasma. As far as we know, this is the first evidence of circulating DNA in septic patients.
10810768 Potential applications of gene therapy in sports medicine. 2000 May Gene therapy has the potential to improve greatly the management of sports medicine injuries. By the expeditious introduction of the appropriate genes to sites of injury, it should prove possible to initiate healing responses in those tissues that normally fail to heal, to accelerate healing in tissues which do naturally heal, and to improve the quality of the repair tissue. In addition, genes with anti-inflammatory properties offer novel possibilities for the control of chronic, sports related inflammation. None of these applications of gene therapy in sports medicine is yet in the clinic. It would seem, however, only a matter of time before the first clinical trials emerge. Their acceptance will be facilitated by the two human protocols that are presently underway for the treatment of rheumatoid arthritis. The present status of sports medicine gene therapy is summarized in Table 3.
10090183 Anteroposterior atlantoaxial subluxation in cervical spine osteoarthritis: case reports an 1999 Mar Nontraumatic anteroposterior atlantoaxial subluxation (AAS) has been described in several rheumatic or inherited disorders, especially rheumatoid arthritis and to a lesser extent the inflammatory spondyloarthropathies. We describe AAS secondary to osteoarthritis (OA) of the cervical spine in a 76-year-old man and a 73-year-old woman with severe cervical OA, symptomatic C1-C2 facet joints, and signs of generalized OA. Only 6 similar cases exist in the literature. OA should be added to the causes of AAS, and conversely AAS should be assessed in cases with severe OA of the upper cervical spine.
9585886 Development of the selective adsorbent for EDA containing fibronectin using heparin immobi 1998 Apr We have noticed that extra domain A containing fibronectin (EDA(+)FN) is closely related to inflammatory diseases and accordingly investigated a selective adsorbent to remove EDA(+)FN, which may increase the severity of the symptoms, from the plasma of rheumatoid arthritis (RA) patients. Three types of heparin immobilized cellulose (HC) were prepared and their adsorptive properties were evaluated by batchwise adsorption tests. The results showed that EDA(+)FN was adsorbed more efficiently than total FN on HC. In particular HC in which heparin was immobilized to amino residue had an excellent capacity. The adsorption rates of EDA(+)FN, total FN and antithrombin-III were 89, 15 and 17% respectively. This adsorbent is extremely useful in selectively removing EDA(+)FN from plasma.
9521358 The erythrocyte sedimentation rate: old and new clinical applications. 1998 Mar BACKGROUND: The erythrocyte sedimentation rate (ESR) is a simple and inexpensive laboratory test. It is commonly used to assess the acute phase response. METHODS: A review of the recent literature was done to evaluate the role of the ESR and its importance in different clinical conditions both inflammatory and noninflammatory. RESULTS: Despite the critical role cytokines have in inflammatory conditions, the ESR still maintains its important role in the diagnosis and follow-up of rheumatoid arthritis and temporal arteritis. Recently, ESR has been reported to be of clinical significance in sickle cell disease, osteomyelitis, and, surprisingly, in noninflammatory conditions such as stroke, coronary artery disease, and prostate cancer. Erythrocyte sedimentation rate measured by the Westergren method is marginally affected by age, race, and blood storage. CONCLUSION: Despite its importance in many clinical conditions, ESR should be used only as a clinical guide to aid the diagnosis, management, and follow-up of these different clinical situations.
9058664 Salazosulfapyridine suppresses chondrocyte mediated degradation induced by interleukin 1be 1997 Mar OBJECTIVE: To investigate the effects of salazosulfapyridine (SASP) and methotrexate (MTX) on interleukin (IL)-1beta treated rabbit chondrocytes. METHODS: Normal rabbit chondrocytes were cultured to confluency. IL-1beta was added to serum-free culture medium in the presence or absence of SASP or MTX. After 2 days' incubation, the effects were evaluated from the responses of metalloproteinases, glycosaminoglycan (GAG), and prostaglandin E2 (PGE2). RESULTS: SASP and MTX suppressed GAG and collagenase release into the culture medium from IL-1beta stimulated rabbit chondrocytes in a dose dependent manner. Only SASP suppressed stromelysin and PGE2 release. CONCLUSION: SASP may have a protective effect on cartilage degradation of patients with rheumatoid arthritis.
19078445 Fibromyalgia-Like Syndrome Secondary to Addison's Disease. 2000 Feb Fibromyalgia is a syndrome of musculoskeletal pain and tenderness in specific sites, fatigue, and sleep disturbance. Fibromyalgia may occur in patients with rheumatoid arthritis and other connective tissue diseases. Despite the fact that fibromyalgia patients may have alterations in the hypothalamic-pituitary-adrenal axis, no relationship had been established between fibromyalgia and diseases of the adrenal cortex. We report a case of a 46-year-old woman who presented with a new onset of a fibromyalgia-like syndrome meeting all American College of Rheumatology criteria except chronicity. Additional clinical features, including skin pigmentation, mild hypertension, and hyponatremia, as well as further laboratory testing led to a diagnosis of autoimmune Addison's disease. After steroid replacement, the symptoms of fibromyalgia disappeared. This is the first case in English-language literature of fibromyalgia secondary to Addison's disease. We suggest Addison's disease should be considered in the differential diagnosis of any patient with a fibromyalgia-like syndrome.
24383778 Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pul 2001 Dec Abstract A 57-year-old woman with RA of 10 years' duration presented with a history of right coxalgia. Three weeks after total hip arthroplasty, the patient developed an acute pulmonary embolism. The results of screening for hypercoagulable states revealed a protein S (PS) deficiency, and all PS values, i.e., total PS antigen, free PS antigen, and PS cofactor, were lower than the normal ranges, showing that the patient had type I PS deficiency. She had no past history of embolism or deep venous thrombosis. The values of three PS-related parameters were also lower than normal in her daughter. The responsible mutation may be located on exon 15 of genomic PS DNA, as indicated by polymerase chain reaction. We therefore diagnosed hereditary PS deficiency.
11560834 The ferromagnetic pillow: a potential MR hazard not detectable by a hand-held magnet. 2001 Sep This paper describes an incident in which an apparently normal hospital pillow became a ferromagnetic missile when brought into the proximity of a 1.5 T MR system owing to a fine internal spring system within the pillow. Measurements revealed that the 1 kg pillow reached a maximum velocity of 33.7 km h(-1) after undergoing a maximum acceleration of 9.9g. Non-pathological cervical spines should sustain the measured forces and torques without significant injury. However, the effect could be injurious or even fatal to patients suffering from an existing cervical instability, for example due to rheumatoid arthritis. Of more general concern is the fact that the use of a powerful hand-held magnet did not reveal the presence of ferromagnetic components in this instance. Large objects containing sparsely distributed ferromagnetic materials may not be deflected by such a magnet but could still represent a hazard in the MR environment.
11417306 A case of nodular scleritis in association with Behcet's disease. 2001 Mar Approximately 50% of patients with scleritis are known to be associated with systemic connective tissue diseases or vasculitic diseases such as rheumatoid arthritis (RA), Wegener's granulomatosis, relapsing polychondritis, and systemic lupus erythematosus. The patients with scleritis in association with Behcet's disease (BD) have been rarely described in the literature. We report a 46-year-old female patient with BD who developed the nodular scleritis.
10750004 Endoscopic bursal resection: the olecranon bursa and prepatellar bursa. 2000 Apr We treated 31 cases of olecranon bursitis and 19 cases of prepatellar bursitis. The average duration of symptoms before surgery was 1.1 years with a range of 3 months to 4 years. All patients had had preoperative aspiration and injection of cortisone. Patients underwent an arthroscopic bursal resection, removing all the bursal sack that could be seen. The results indicated that 86% of patients after olecranon bursectomy had no pain whatsoever. In the patients with prepatellar bursitis, 66% had no pain whatsoever, but we did note some residual tenderness in 24% of the patients, and 10% had pain on kneeling. There were 2 recurrences; 1 patient had rheumatoid arthritis and 1 repetitive daily trauma to the knee. There were no significant complications.
10686640 [Neuromuscular complications of long-term treatment of inflammatory diseases. 3 cases]. 1999 Dec Chloroquine and colchicine, widely used in internal medicine practice for a variety of inflammatory diseases including systemic lupus erythematosus, rheumatoid arthritis, familial Mediterranean fever, and Behçet's disease, may induce neuromuscular complications. Physicians must be familiar with this diagnosis as this iatrogenic neuromuscular pathology may simulate polymyositis, leading thus to inappropriate treatment with prednisone whereas the only effective treatment is to discontinue the drug involved whenever possible. We report three cases of toxic myopathy and/or neuropathy related to chronic chloroquine or colchicine therapy for systemic diseases, and outline the main points to be considered in this situation.
10101218 Recent advances in neurokinin receptor antagonists. 1999 May The structurally related neuropeptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), which belong to a family of molecules termed tachykinins and are widely distributed in the central and peripheral nervous systems, influence the function of many tissues. SP and NKA have links to the following chronic diseases: asthma, inflammatory bowel disorders, rheumatoid arthritis, pain and psychiatric disorders. These peptides exert their effects through three G-protein coupled receptor subtypes, namely, the NK1, NK2, and NK3 receptors. Non-peptide antagonists of these receptors may provide opportunities for disease treatments. In this review, the very recent advances in nonpeptide neurokinin receptor antagonists will be described with an emphasis on structure-activity relationships which have been developed.
9973659 ber die laquo;Omnipotenz>> der Chelattherapie. 1998 About the 'Omnipotence' of the Chelation Therapy In the eighties the 'method of treatment proven in many thousands of cases over 20 years' was transferred from the USA to Germany (enjoys a priori considerable faith) using very dubious promises. It was Clarke et al. who introduced this 'therapy' in 1955. The dubious promise was to maintain that the chelation therapy eliminates or alleviates symptoms in the case of the following illnesses: Alzheimer's disease, senility, schizophrenia, rheumatoid arthritis, osteoarthritis, gout, renal calculus, apoplectic coma, gallstones, multiple sclerosis, osteoporosis, chronic fatigue syndrome, varicose veins, hypertension, failure of memory, scleroderma, Raynaud's disease, digitalis intoxication, intermittent claudication, diabetic ulcer, disturbance of the blood supply, ulcer on the legs, snake poison, impotence, emotional difficulties, defective hearing, vision disorder. There is not the slightest proof of effectiveness for any of the listed indications. The burden of proof lies with the supplier. Even in the case of the relatively often examined peripheral atherosclerotic changes (claudicatio intermittens) there is no proof that EDTA has a greater effect than placebo. For coronary heart disease too there is no evidence for any usefulness of the chelation therapy beyond that of a placebo effect. Only controlled studies can help to improve the therapy in the sense of 'Evidence-based medicine'. Retrospective investigations on thousands of patients cannot 'prove' anything, although this is maintained again andagain.
9914949 Cytokines in autoimmune disorders. 1998 Cytokines are important protein mediators of immunity, inflammation, cell proliferation, differentiation, fibrosis, etc. (Oppenheim and Saklatvala, 1993). As these are the major biological processes underlying autoimmunity, it is not surprising that there is now convincing evidence that cytokines have an important role in the pathogenesis of autoimmunity (Brennan and Feldmann, 1996; Feldmann et al., 1996). There has been much progress since we first highlighted the role of cytokines such as IFN gamma in autoimmunity in the early 1980s (Bottazzo et al., 1983). The number of cytokines molecularly cloned has increased greatly, and the biochemical and structural basis of their action are partly understood, as cytokine genes and that of their receptors have been cloned. Knowledge of cytokine signalling is rapidly expanding (see Chapter XIII). In medical terms, clear evidence of the importance of cytokines in autoimmunity is demonstrated by therapeutic advances. Thus it is possible to dramatically improve patients with rheumatoid arthritis and Crohn's disease by blocking TNF alpha, and a new target for therapy, TNF alpha, has thus been validated for both these diseases.
9372342 Fatality due to severe Salmonella enteritis associated with acute renal failure and septic 1997 Oct A 66-year-old man was hospitalized for abdominal pain and diarrhea of more than 10 times a day. He had been under regular medication with prednisolone for rheumatoid arthritis. On admission, laboratory data and clinical examination indicated inflammation, dehydration, acute renal failure with a high level of serum musculogenic enzyme (creatine kinase), and ileus. Salmonella enteritidis was isolated from his fecal and blood samples. The patient died within 24 hours after admission, and autopsy showed hemorrhagic necrotic enteritis localized to the ileum. Enterocolitis due to Salmonella enteritidis, which is usually an acute self-limited gastrointestinal illness, may occasionally be a serious and lethal disease.