Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 11907517 | Methotrexate treatment for refractory subacute cutaneous lupus erythematosus. | 2002 Apr | Methotrexate is beneficial in rheumatoid arthritis and has been used in small studies of patients with systemic lupus erythematosus. We describe a patient with severe subacute cutaneous lupus erythematosus refractory to therapy with antimalarials and corticosteroids. Treatment with methotrexate resulted in complete clearing of the skin lesions without any side effects. | |
| 11874847 | Progress towards an OMERACT-ILAR guideline for economic evaluations in rheumatology. | 2002 Apr | A working report from the OMERACT Health Economics Group. The group is working towards creating common standards for economic evaluation in rheumatology and also towards improving the scientific underpinning of economic evaluation, particularly pertaining to the rheumatic diseases. Preliminary recommendations for "reference cases" in osteoporosis, rheumatoid arthritis, and osteoarthritis are proposed. | |
| 11805940 | One-stage débridement and knee fusion for infected total knee arthroplasty using the hybr | 2002 Jan | In 1997 and 1998, a hybrid fixator was used for a one-step arthrodesis in 2 cases of infected total knee arthroplasty. One patient had rheumatoid arthritis, and the other had an infected reimplant arthroplasty. Neither patient was a candidate for reimplantation. Fusions were achieved with the hybrid frame in an average of 10 weeks. All signs of local and systemic infections were eliminated. After 24 months for patient 1 and 37 months for patient 2, both are infection-free and ambulatory without the aid of a wheelchair. | |
| 15678887 | [Immunomodulatory activities of statins]. | 2004 Dec | HMG-CoA (3-hydroxy-3-methyglutaryl coenzyme A) reductase inhibitors (statins) reduce cardiovascular morbidity and mortality. Although statins work in part via lipid modulation, several findings of statins indicate they have broader properties, including alteration of inflammatory pathways. Ex-vivo activities of statins include suppression of adhesion molecule expression, MHC class II expression, and effects on reactive oxygen and nitrogen intermediate production. Statins also modify apoptosis in smooth muscle and endothelial cells leading to altered vascular function and neovascularization. These properties offer the potential to modify the states of chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis with drugs that show minimal toxic effects in both the short and long term. | |
| 15035786 | Regulation of bone lysis in inflammatory diseases. | 2003 | Focal bone erosion is a major pathological feature of several common inflammatory diseases. Over the past decade there have been major advances in our understanding of the factors that regulate osteoclast formation and activity. It is now apparent that receptor activator for NFkappaB (RANK), its ligand RANKL (also known as TRANCE, osteoclast differentiation factor and osteoprotegerin (OPG) ligand) and the RANKL inhibitor OPG, are the major factors regulating osteoclast formation. These molecules influence normal bone physiology and now there is growing evidence that RANK-RANKL interactions also regulate osteoclast formation in disease. This paper reviews recent findings showing expression of RANK, RANKL and OPG in inflammatory diseases including rheumatoid arthritis, periodontal disease and peri-implant loosening. It is emerging that OPG and RANKL are key molecules regulating bone loss in disease and therapeutic intervention that targets these molecules may be helpful in treating a wide range of diseases. | |
| 14648093 | [Innovations in total knee arthroplasty]. | 2003 | The development of total knee arthroplasty started in the fifth decade last century. Modern total knee joint systems represent a high grade of modularity for a usage within the whole range of joint destruction situations, such as for rheumatoid arthritis. Innovations for improved long term survival can be seen in methods reducing aseptic loosening, such as new implant materials or mobile platforms. Moreover improved surgical techniques for precise component orientation and reconstruction of a neutral leg axis have been introduced using computer assisted surgery. So far the results using this technique are very promising. Long term results are not yet available. | |
| 14616717 | Recurrent catheter-related Rhodotorula rubra infection. | 2003 Aug | A 34-year-old male receiving chronic parenteral nutrition for treatment of short bowel syndrome and intermittent immunosuppressive agents for juvenile rheumatoid arthritis developed recurrent, catheter-associated Rhodotorula rubra fungemia over a one-year period. Infection with this yeast is associated with insertion of central venous catheters. Recurrence of R. rubra infection is an unusual event that presumably occurred because of chronic skin colonization by the organism. | |
| 12964045 | Peroxyl radical scavenging capability of fish sauces measured by the chemiluminescence met | 2003 Oct | Oxygen-related free radicals have been suggested as a cause of aging and various diseases, for example, various cancers and rheumatoid arthritis. A radical scavenger as an antioxidant has been sought in foods. Fish sauces are traditional Asian fermented seasonings. Using the luminol chemiluminescence method, the peroxyl radical scavenging capability of fish sauces was examined. From the IC50 values, many fish sauces have been shown to have a strong scavenging capability as well as soy sauces. A scavenging mechanism is also proposed. | |
| 12924107 | [Rehabilitation of rheumatic diseases]. | 2003 | Rehabilitation aims at restoration of function and integration of the disabled or chronically ill patient in his social environment. Cooperation of health professionals in a multidisciplinary rehabilitation team is required. Functional deficits are defined on the levels of impairment, activity, and participation. A rehabilitation concept tailored to the individual patient and the use of outcome measures are mandatory. The principles of rehabilitation of rheumatoid arthritis and osteoarthritis are outlined. | |
| 12575915 | Oxidative stress and apoptosis in immune diseases. | 2002 Sep | Antigenic stimuli increase ROS that influence T-cell activation by interfering with the oxidant-antioxidant balance. Oxidative stress takes place when excess of ROS production is not counterbalanced by antioxidant mechanisms and bcl-2 gene product that inhibits apoptosis by interacting with mitochondrial superoxide dismutase. ROS Excess induces apoptosis both by activation of NF-kB-dependent genes and DNA damage. The latter has been shown to elicit the activation of poly-ADP-ribose transferase and the accumulation of p53, thus determining apoptosis. Additionally, oxidative stress may induce formation of cell membrane oxidized lipids, potent inducers of apoptosis. Oxidative stress is also involved in immune diseases. In AIDS, ROS excess and deficiency of antioxidants lead to apoptosis and virus activation. ROS produced at sites of chronic inflammation, have genotoxic effects. As a consequence, abnormalities of the p53 genes might explain the conversion from an inflammatory phase into autonomous progression of rheumatoid arthritis or other chronic inflammatory disorders. | |
| 12235851 | Study on the roles of cytokines involved in mycobacterial infection. | 2002 Aug | The roles of various cytokines in early-phase mycobacterial infection were investigated utilizing murine tuberculosis models. Among them, IFN-gamma and TNF-alpha are very important in protective immunity against mycobacterial infection. This finding is closely associated with human tuberculosis. It is reported that persons with IFN-gamma receptor 1 deficiency and patients with rheumatoid arthritis and Crohn's disease are susceptible to Mycobacterium tuberculosis. It is expected that a novel immunotherapy and a diagnostic method of tuberculosis are developed by clarifying roles of various cytokines immunologically in early-phase mycobacterial infection. | |
| 12186258 | Regenerative medicine through mesenchymal stem cells for bone and cartilage repair. | 2002 Jul | Bone and cartilage defects are common features of bone fracture and joint diseases, such as rheumatoid arthritis or osteoarthritis, that have great social and economic impact on the aging occidental population. Despite progress in orthopedic surgery, bone and cartilage repair is a major challenge as large defects will not spontaneously heal. Recent investigations on the stromal mesenchymal stem cell (MSC) offer a new perspectivefor bone and cartilage tissue engineering. However, the standard offull healing is extremely demanding and may be achieved through the engineering of MSCs combined with scaffolds and growth factors as recombinant proteins, or using a gene therapy approach. | |
| 18365043 | Phosphinegold(I) thiolates--pharmacological use and potential. | 2003 | A brief overview of the use of gold compounds in medicine, namely in the treatment of rheumatoid arthritis is presented, including that of the orally-administered triethylphosphinegold(I) tetraacetylatedthioglucose species, auranofin. A summary of an evaluation for anti-arthritic activity of novel phosphinegold(I) thiolate analogues containing biologically active thiols is given. This shows that compounds with greater efficacy and reduced toxic side-effects, at least in the in vivo model studied, can be developed. More recent investigations on this class of compound have focussed on their putative anti-tumour activity. Significant cytotoxicity and apparent cellular specificity have been discovered for certain phosphinegold(I) thiolates carrying water-solubilising groups. All indications are there that the continued exploration of the medicinal properties of phosphinegold(I) thiolates offers very real opportunities in metallotherapeutics. | |
| 14740402 | [Evaluation of molecular weights of hyaluronate preparations by multi-angle laser light sc | 2003 | Hyaluronate (HA), a glycosaminoglycan polysaccharide, has been used for osteoarthritis, periartritis of the shoulder and rheumatoid arthritis by intraarticular administration, and in ophthalmic surgery such as anterior segment surgery, and eye lotion. In this study, the molecular weight (Mw) of HA preparations were estimated by size-exclusion chromatography (SEC) system consisted of a refractometer (RI) and a multi-angle laser light scattering (MALS). From the results, it has been clarified that a successful characterization of HA samples with Mw up to 2 - 3 x 10(6) g/mol was possible by multidetector system. | |
| 12095463 | Rheumatic mimics and selected triggers of fibromyalgia. | 2002 Aug | Fibromyalgia is a chronic pain syndrome of unknown etiology characterized by diffuse pain and tender points, which have been present for more than 3 months. Many patients with systemic illnesses can have diffuse pain similar to that found in fibromyalgia, including rheumatic diseases such as polymyalgia rheumatica, rheumatoid arthritis, idiopathic inflammatory myopathy, systemic lupus erythematosus, and joint hypermobility. Osteomalacia and thyroid disease are also in the differential diagnosis of diffuse pain and are imminently treatable. In addition, there has been interest throughout the past 10 years in infectious diseases including hepatitis C, Lyme disease, coxsackie B, HIV, and parvovirus infection, which may cause or trigger fibromyalgia. This paper provides a framework to use when identifying these diseases as part of the evaluation of a patient with chronic widespread musculoskeletal pain. | |
| 11926127 | Recombinant antibodies for the selective targeting of tumor neovasculature. | 2002 Mar | Angiogenesis, the sprouting of new blood vessels from preexisting ones, is a characteristic feature of many aggressive solid tumors. Advances in the identification of markers of angiogenesis and new methodologies for the production of human recombinant antibodies are making it possible to deliver bioactive molecules to the tumor neovasculature in a selective fashion. This review illustrates how recombinant antibody derivatives may open new avenues for the imaging and therapy of angiogenesis-related diseases, such as cancer, blinding ocular disorders and rheumatoid arthritis. | |
| 12113888 | Tissue-specific regulation of expression and activity of P-glycoprotein in adjuvant arthri | 2002 Jul | Cyclosporine A and steroids are effective against rheumatoid arthritis and also known as substrates of P-glycoprotein (P-gp). We investigated the effect of arthritis on the hepatic and intestinal P-gp activity in rats, and substantiated the expression level of the hepatic P-gp. Doxorubicin was used as a P-gp substrate. Cumulative biliary excretion and intestinal exsorption of doxorubicin following intravenous administration were compared between adjuvant arthritis (AA) and normal rats. Intestinal P-gp activity was also investigated by intestinal everted sac method, and hepatic P-gp was detected by FITC-labeled antibody and visualized using a confocal laser microscope system. Biliary clearance of doxorubicin in AA rats was significantly decreased from that in normal rats. The expression level of the hepatic P-gp in AA rats was very low compared to normal rats, indicating down-regulation. Intestinal exsorption clearance was not different between AA and normal rats. Permeability of doxorubicin across intestinal everted sac was comparable between AA and normal rats, corresponding to in vivo study. In AA rats, hepatic P-gp activity was decreased due to the reduction of expression level, but intestinal P-gp activity was not changed. Different regulation systems may be involved in liver and intestine. | |
| 12594249 | Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) | 2003 Mar 1 | Collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA) are murine models for rheumatoid arthritis both in terms of their pathology and genetics. Using the F(2) hybrids of the CIA-susceptible, but PGIA-resistant DBA/1 mice, and the CIA-resistant, but PGIA-susceptible BALB/c mice, our goals were to 1) identify both model-specific and shared loci that confer disease susceptibility, 2) determine whether any pathophysiological parameters could be used as markers that distinguish between nonarthritic and arthritic mice, and 3) analyze whether any immune subtraits showed colocalization with arthritis-related loci. To identify chromosomal loci, we performed a genome scan on 939 F(2) hybrid mice. For pathophysiological analyses, we measured pro- and anti-inflammatory cytokines (IL-1, IL-6, TNF-alpha, IFN-gamma, IL-4, IL-10, IL-12), Ag-specific T cell proliferation and IL-2 production, serum IgG1 and IgG2 levels of both auto- and heteroantibodies, and soluble CD44. In addition to multiple CIA- and PGIA-related loci identified in previous studies, we have identified nine new CIA- and eight new PGIA-linked loci. Comprehensive statistical analysis demonstrated that IL-2 production, T cell proliferation, and IFN-gamma levels differed significantly between arthritic and nonarthritic animals in both CIA and PGIA populations. High levels of TNF-alpha, IFN-gamma, IL-2, and Ab production were detected in F(2) hybrids with CIA, whereas T cell proliferation, IL-2 and IFN-gamma production, and a shift to IgG2a isotype were more characteristic of PGIA. Quantitative trait loci analysis demonstrated colocalization of numerous immune subtraits with arthritis-related traits. Quantitative trait loci on chromosomes 5, 10, 17, 18, and X were found to control arthritis in both models. | |
| 15364051 | More sympathy for autoimmunity with neuropeptide Y? | 2004 Oct | Substantial evidence indicates a dysfunctional communication between the sympathetic nervous system and the immune system in Th1-mediated autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In this Opinion, we propose that the sympathetic regulation of immunity is not only mediated by catecholamines but also involves neuropeptide Y (NPY), an additional postganglionic SNS transmitter that is shown to modulate various immunological functions in vitro and in vivo. Based on recent experimental findings, we believe that a more precise understanding of the role of NPY in the regulation of autoimmune Th1 cells will provide novel insights into the neuroimmunological basis of autoimmunity. | |
| 15253677 | The causes of intestinal dysbiosis: a review. | 2004 Jun | Alterations in the bowel flora and its activities are now believed to be contributing factors to many chronic and degenerative diseases. Irritable bowel syndrome, inflammatory bowel disease, rheumatoid arthritis, and ankylosing spondylitis have all been linked to alterations in the intestinal microflora. The intestinal dysbiosis hypothesis suggests a number of factors associated with modern Western living have a detrimental impact on the microflora of the gastrointestinal tract. Factors such as antibiotics, psychological and physical stress, and certain dietary components have been found to contribute to intestinal dysbiosis. If these causes can be eliminated or at least attenuated then treatments aimed at manipulating the microflora may be more successful |