Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1173025 | Benign lymphoepithelial lesions of the salivary glands. | 1975 Jan | The benign lymphoepithelial lesion of the salivary glands has been labeled with multiple, confusing terms. We recommend the abandonment of the vague term of Mikulicz disease. The histopathologic findings of lymphoid infiltration, intraductal proliferation, epimyoepithelial islands, and acinar atrophy are presented. The relationship between this lesion and autoimmune diseases, including Sjögren syndrome, is noted. Difficulty of histopathologic differentiation between this lesion and malignant lymphoma can occur. The association of the benign lymphoepithelial lesion with the simultaneous presence or future development of lymphoma is discussed. | |
| 3891940 | Lymphocytic interstitial pneumonia identified as lymphoma of mucosa associated lymphoid ti | 1985 Jun | The widespread interstitial pulmonary infiltration in two patients, showing the clinical, radiological and histological features of lymphocytic interstitial pneumonia (LIP), has been characterized by histological and immunological criteria as malignant lymphoma of follicle centre cell (FCC) origin with plasmacytic differentiation. One patient also had malignant lymphoma of the parotid glands which had been present for many years and was previously considered benign (benign lymphoepithelial lesion). The other patient had a long history of Sjögrens syndrome. The lymphomas in these patients are presented as typical examples of malignant lymphoma of mucosa-associated lymphoid tissue. | |
| 3872074 | Complete heart block in a fetus associated with maternal Sjögren's syndrome. | 1985 Mar 1 | This report illustrates the case of a fetus who was diagnosed by M-mode echocardiography, at the twentieth week of gestation, as having a complete heart block. The mother had a positive antinuclear antibody test result with antibodies directed against the Ro (SSA) and La (SSB) antigen system consistent with the diagnosis of Sjögren's syndrome. Management and outcome of the pregnancy are discussed. | |
| 6691757 | Fat embolism in sickle cell disease. Report of a case with brief review of the literature. | 1984 Jan | This is a unique instance of fatal fat embolism secondary to bone marrow necrosis in a patient with sickle cell-hemoglobin C disease, systemic lupus erythematosus, and Sjögren's syndrome. An elevated level of IgG and treatment with corticosteroids appeared to be major factors in the death of this patient. This complication occurs most often in patients with sickle cell-hemoglobin C disease, especially in pregnant women near term. It should be suspected in any patient with sickle cell disease in whom unexplained fever, respiratory, and neurologic symptoms typical of fat emboli develop following the onset of bone pain. Exchange blood transfusion may be lifesaving. | |
| 6972210 | Serologic studies in patients with keratoconjunctivitis sicca. | 1981 May | Thirty-two patients with keratoconjunctivitis sicca (KCS) were screened for the presence of antinuclear antibodies, rheumatoid factor, and autoantibodies associated with Sjögren's syndrome (designated SS-A and SS-B). None of these patients had or were found to have clinical evidence of connective-tissue disease. The conditions of 19 (59%) patients were antinuclear-antibody-positive and 18 (56%) were rheumatoid-factor-positive. We found SS-A and/or SS-B autoantibodies in ten (31%) patients. There seems to be a high incidence of serologic abnormalities in patients with KCS, even when those patients with connective-tissue disease are excluded. Serologic testing seems to be a useful adjunct in the early diagnosis of primary Sjögren's syndrome. The presence of SS-A and SS-B autoantibodies correlated well with the clinical diagnosis of Sjögren's syndrome and seemed to identify the conditions of patients who may have a higher incidence of systemic complications with KCS. | |
| 6945655 | [Lesion of the parotid, still known as Godwin's syndrome. A case report (author's transl)] | 1981 | Parotidectomy with conservation of the facial nerve, followed by radiotherapy to lymph glands, was employed to treat a benign lympho-epithelial lesion in the parotid. Clinical characteristics, therapy, and prognosis of this rare affection are described though diagnosis is difficult, the presence of such a lesion should be considered in all cases of parotid tumours. | |
| 818413 | Decreased spleen size and increased neutrophils in patients with Felty syndrome. Effects o | 1976 May 17 | Three patients with Felty syndrome were treated with gold sodium thiomalate. In all three, there was an increase in total numbers of peripheral blood neutrophils and total white blood cells, as well as marked clinical improvement of the arthritic complaints. In two patients there was a marked decrease in spleen size. | |
| 4726949 | Progressive systemic sclerosis. "Something old, something new, something borrowed, somethi | 1973 Aug | These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. David W. Martin, Jr., Assistant Professor of Medicine, and Kenneth A. Woeber, Associate Professor of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine. Requests for reprints should be sent to the Department of Medicine, University of California, San Francisco, CA 94143. | |
| 4008179 | Lacrimal gland autoimmunity in New Zealand mice. | 1985 Summer | We studied the spleen cell-mediated as well as antibody-mediated cytotoxicity to lacrimal gland acinar cells in New Zealand mice, an excellent animal model of Sjögren's syndrome. We found no difference in spleen cell-mediated cytotoxicity between young (3 months old) and old (6 to 12 months old) animals. With age, however, New Zealand mice developed an increasing level of serum autoantibodies to the lacrimal gland acinar cells. Such antibodies may play a role in the tissue damage of the lacrimal gland in these mice. | |
| 6566363 | Collagen-vascular diseases. | 1984 Jun | Some of the collagen-vascular diseases and overlap syndromes included are polymyosititis, systemic lupus erythematosus, scleroderma, Sjögren's syndrome, and Raynaud's phenomenon. Because diagnosis and treatment can be complicated, primary care physicians may want to seek experienced consultation. | |
| 6840751 | Clinical and biologic significance of antibodies to Ro/SSA. | 1983 May | Study of the clinical associations of antibodies to the soluble antigens Ro/SSA and La/SSB leads to several conclusions. Production of such antibodies are linked to the D locus antigens DR2 and DR3, suggesting involvement of disease susceptibility or immune response genes in the regulation of their synthesis. Genetics therefore provides one of the factors that contribute to the disease expression and the clinical heterogeneity that characterize systemic lupus erythematosus (SLE). The uniform presence of anti-Ro/SSA in neonatal lupus and the almost uniform presence of these antibodies in the vasculitis of Sjögren's syndrome suggest the participation of these antibodies in the immunopathogenesis of these particular clinical manifestations. Finally, identification of the molecular nature of these antigens as RNA-protein conjugates and the ability of the antibodies to La/SSB to bind viral-specific RNA-protein conjugates provide clues that may lead to elucidation of etiologic events in the development of SLE. | |
| 1082749 | Cryoimmunoglobulinemia in Felty's syndrome. | 1976 Jan | Seven of 9 patients with Felty's syndrome exhibited cryoglobulins in greater amounts than found in uncomplicated RA but similar to amounts found in RA with vasculitis. Antinuclear antibodies were found in high titer in the sera and cryoglobulins of Felty's patients; when compared to SLE patients, whose sera and cryoglobulins also contained antinuclear factors, an antinuclear antibody reacting with nuclei of polymorphonuclear granulocytes appeared to be selectively concentrated in the cryoglobulins of some Felty's patients. | |
| 674550 | Analgesic nephropathy: an important cause of chronic renal failure. | 1978 Jan | Study of case-notes and autopsy reports of patients with renal disease suggests that analgesic nephropathy is responsible for at least 12 per cent of cases of chronic renal failure, Between 1970 and 1975 eight new cases of analgesic nephropathy were seen annually in a population of three-quarters of a million. This is equivalent to an incidence of 490 new cases per year in England and Wales. Fifty-five patients with analgesic nephropathy were followed from one to 84 months for a total of 190 patient years. Changes in renal function were correlated with bacteriuria, hypertension and analgesic consumption. One-third of the cases had been misdiagnosed and analgesic abuse was only revealed by thorough examination of case-notes and autopsy records, together with careful questioning of patients and relatives. A number of cases had been classified as chronic pyelonephritis. The calculated survival rate at five years was 44 per cent. Mortality was related to the level of analgesic consumption and the degree of renal failure at the time of diagnosis. The prognosis was poor if serum creatinine at presentation was greater than 400 mumol/l. There was no significant correlation between deterioration in renal function and bacteriuria or hypertension. Forty-two per cent of the patients were taking analgesics for arthritis; 27 per cent had rheumatoid arthritis. Most had been taking large quantities of analgesic mixtures containing phenacetin. Renal papillary necrosis was present in only 26 per cent on intravenous urography but was found in all those examined at autopsy. Twenty thousand, two hundred and twenty-nine autopsy reports were examined for the presence of renal disease. Renal papillary necrosis was found in 0.41 per cent, and could be attributed to analgesic nephropathy in 24 per cent. In patients under 65 years of age analgesic nephropathy appeared to be a more frequent cause of death than chronic pyelonephritis. The report indicates the need for careful enquiry about analgesic consumption in all patients with renal disease, and emphasizes the importance of early diagnosis and cessation of analgesics in suspected cases of analgesic nephropathy. | |
| 6316400 | Cryptogenic fibrosing alveolitis associated with peripheral neuropathy. | 1983 Summer | Eight patients who presented with fibrosing alveolitis and developed peripheral neuropathy are described. Seven had a positive rheumatoid factor, but only one had arthritis. The neuropathy affected both motor and sensory fibres. Two patients underwent peripheral nerve biopsy, one showing vasculitis and the other an axonal neuropathy. The two disorders responded differently to corticosteroid therapy, and immunosuppressant drugs may be useful in treating the neuropathy. The similarities of the patients suggests that this uncommon association is a real category. | |
| 3871835 | Induction of severe autoimmune disease in normal mice by simultaneous action of multiple i | 1985 Feb 1 | Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute. | |
| 6607734 | Clinical and laboratory associations of anticentromere antibody in patients with progressi | 1984 Feb | Anticentromere antibody (ACA) was found in the serum of 4 (3%) of 120 patients with progressive systemic sclerosis with diffuse scleroderma and in 69 (49%) of 141 with progressive systemic sclerosis with the CREST syndrome variant. The 69 CREST syndrome patients with ACA were compared with the 72 CREST syndrome patients without ACA. The former were older at the onset of symptoms and significantly more frequently female (97% versus 78%, P less than 0.01). Those with ACA more often had telangiectasiae of the digits (93% versus 75%) and calcinosis (55% versus 22%). These differences were also present after the groups were stratified according to duration of disease. Cutaneous involvement was similar in both degree and extent in the 2 groups; 20% of CREST patients both with and without ACA had forearm skin thickening. Pulmonary interstitial fibrosis on chest roentgenogram and restrictive disease on pulmonary function testing were significantly less frequent in the ACA patients. Gastrointestinal involvement, pulmonary arterial hypertension, and cardiac abnormalities were similar in both groups, and there has been no difference in survival between CREST syndrome patients with and without ACA. Tissue typing studies revealed a significant association between ACA and HLA-DR1. | |
| 3919659 | Demonstration and identification of monoclonal proteins in the urine of patients with Sjö | 1985 Feb | Fresh sera and concentrated urine from 17 patients with primary Sjögren's syndrome (SS) were fractionated by high-resolution agarose electrophoresis to investigate the presence of monoclonal immunoglobulins or their components. Homogeneous protein bands were found in the gamma-globulin region in 47% of serum samples and 76% of urine specimens of all patients tested. These monoclonal proteins were detected more often in patients with extraglandular SS (77% in serum, 100% in the urine) than in patients with glandular SS (14% in serum, 43% in the urine). Immunofixation electrophoresis showed that the majority of these monoclonal proteins were free kappa or lambda light chains. Fractionation of unconcentrated parotid salivas from five SS patients failed to reveal the presence of monoclonal light chains or immunoglobulins. The present findings further substantiate our previous observation that a monoclonal process coexists with the polyclonal activation in SS patients. | |
| 6319447 | Possible existence of anti-renal tubular plasma membrane autoantibody which blocked parath | 1984 Feb | We examined the effects of serum from a patient with pseudohypoparathyroidism type II and Sjögren's syndrome on renal function in rats. Infusion of 50-100 mg of the patient's immunoglobulin G (IgG) fraction inhibited the PTH-induced increase in urinary phosphate excretion, but had no effect on the PTH-induced increase in urinary cAMP excretion. Infusion of the IgG fraction obtained from the sera of control subjects did not affect PTH-induced increases in urinary excretion of either cAMP or phosphate. Binding of the patient's serum IgG fraction to the membrane of isolated rat renal cortical tubules was observed by immunofluorescent techniques. We conclude that the IgG fraction from the serum of this patient with pseudohypoparathyroidism type II and Sjögren's syndrome contains an autoantibody(ies) reacting with a component(s) of renal tubular plasma membranes and blocking PTH-induced phosphaturia. | |
| 315097 | Auto-antibodies in Sjögren's syndrome. With special reference to liver-cell membrane anti | 1979 | Sera from 70 patients with Sjogren's syndrome (SS), of whom 40 had primary and 30 secondary SS, were tested for various auto-antibodies of the IgG, IgA and IgM classes. 20% had liver-cell-membrane antibody (LMA), 90% had anti-nuclear antibodies (ANA), 40% salivary-gland antibodies (SGA), 13% anti-mitochondrial antibodies (AMA), 33% smooth-muscle cell antibodies (SMA), 9% skeletal-muscle antibodies (SKA) and only 1% had parietal-cell antibodies (PCA). In addition, 53% had IgM rheumatoid factor and 6 patients with anti-DNA antibodies all had SLE. 64% had increased serum IgG, 24% IgA and 14% IgM. A significantly higher incidence of ANA was found within all three Ig classes in patients with secondary SS. AMA and IgM-rheumatoid factor were also found to be elevated in this group. On the other hand, SGA occurred most frequently in patients with primary SS. LMA was mainly of the IgG class and IgG AMA and SMA were more often present in these patients than in those with a negative LMA reaction. The results of the investigation suggest inter alia that inflammatory liver disease, although not indicated by either the case history, physical examination or biochemical values, is probably present in patients with SS. | |
| 6354194 | Lymphocyte infiltrations of the gastric mucosa in Sjögren's syndrome. An immunoperoxidase | 1983 Oct | Biopsy specimens of the gastric mucosa from 7 patients with primary or secondary Sjögren's syndrome were studied using the immunohistochemical avidin-biotin-peroxidase complex (ABC) method. Monoclonal antibodies (OKT series) were used as a primary layer to detect the surface antigens of various lymphocyte subsets in situ. Chronic inflammation with mononuclear cell infiltrates and/or glandular atrophy was seen in all 7 biopsy specimens. Immunohistochemical staining showed that the cell infiltrates consisted mainly of OKT3-positive T lymphocytes. In 1 patient plasma cells predominated at the sites of inflammation. Most of the T cells were OKT4-reactive lymphocytes, the OKT4/OKT8 ratio varying between 3 and 7. These findings from the gastric mucosa are in agreement with those obtained from the salivary glands of patients with Sjögren's syndrome and confirm the view that Sjögren's syndrome is a systemic disease affecting many organs, rather than a local disease restricted only to some exocrine glands. |