Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3258915 | High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis. | 1988 Feb | Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500 mg/m2) followed by leucovorin (50 mg/m2). Four courses of chemotherapy were given over a 2-month interval. At the end of the final course, there was a 50% or greater improvement in joint swelling and pain indices and morning stiffness in all patients. Clinical responses persisted for 6-14 weeks posttherapy. High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes. | |
| 2524320 | [Telethermographic evaluation of the intra-articular administration of thymopentin in rheu | 1989 Mar 15 | Fifteen subjects with rheumatoid arthritis defined as "classical" or "definite" according to A.R.A. criteria and classified according to Steinbrocker as stages I to III were submitted to knee joint infiltration (bilateral where both knees were involved) with 50 mg thymopentin in 1 ml, once a week for five weeks. Telethermographic examination was performed in all cases in order to evaluate the thermal inflammatory component before the first and 48 hours after the last infiltration. In none of the patients with the exception of only one case, did the drug lead to a significant change of the thermal index. This evaluation does not take into account any other objective and subjective parameters the study of which was beyond the scope of the above research. | |
| 2754671 | Multiple stress fractures in the hindfoot in rheumatoid arthritis. | 1989 May | A case of nontraumatic bilateral multiple stress fractures of the hindfoot in a 60-year-old white man with rheumatoid arthritis (RA) is described. Review of the literature indicates that stress fractures of the calcaneus and other bones of the hindfoot are an unusual complication of RA and have not been reported previously. Factors leading to the development of stress fractures in the patient with RA are discussed. | |
| 3954462 | Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treate | 1986 Jan | A 49 year old man with rheumatoid arthritis developed a proliferative glomerulonephritis with progressive renal impairment during treatment with D-penicillamine. His renal function continued to deteriorate after the drug was stopped but improved after treatment with corticosteroids and azathioprine. | |
| 1792025 | Oesophageal involvement in rheumatoid arthritis patients: a study with oesophageal radionu | 1991 Oct | Rheumatoid arthritis (RA) is an inflammatory disease affecting mainly the joints. In addition, signs of systemic disease are likely to be present although they are not always clinically evident. Oesophageal motility dysfunction, present in 75% of progressive systemic sclerosis patients, was also reported in various other connective tissue diseases. The present study involved 32 rheumatic patients devoid of any gastrointestinal complaints or diseases: 16 RA, nine Raynaud's syndrome and seven mild osteoarthritis as controls. Oesophageal transit was assessed by using 81Krm radionuclide scan, a sensitive and non-invasive technique. Diffusing lung capacity for carbon monoxide (DLCO) was performed as evidence of subclinical systemic involvement. Abnormal oesophageal transit was observed in 5/16 RA (31%). Two of them were subsequently discarded due to the presence of asymptomatic goiter and asymptomatic gastrointestinal reflux leaving 3/14 RA for analysis. They all had extra-articular features (EAF) (pericarditis, nodules) and two of them had diminished DLCO. Two with Raynaud's syndrome had abnormal oesophageal transit but none of the controls had abnormal oesophageal transit. Upper gastrointestinal dysfunction after exclusion of symptomatic patients appears thus to be not very frequent in RA, even when a sensitive technique is used. Radionuclide transit scanning of the oesophagus is not a more useful method than others in detecting early EAF in RA. | |
| 3944225 | Factors influencing mortality in rheumatoid arthritis. | 1986 | The prognosis in rheumatoid arthritis respecting mortality was studied in a consecutive series of 489 hospital patients over a period of 18 years. The relative risk of mortality was raised in both men (2.6; p less than 0.001) and women (3.4; p less than 0.001). In the women the relative risk was also influenced by prior duration of RA and was characterised by a diminution in risk 5-9 years after first presentation. Relative risks for men were more uniformly distributed over time. Annual excess mortality rates were strongly associated with age at first presentation in women, the rate increasing with increasing age in both the group seen within 5 years of onset of disease (chi 2(1) for trend = 30.4; p less than 0.001) and in the later referral group (chi 2(1) = 34.0; p less than 0.001). A similar but much less marked effect was observed in men in the early referral group (chi 2(1) = 13.7; p less than 0.001) only. These results suggest that initially women may have a milder form of disease and that hormonal status may affect prognosis. Future long-term therapeutic studies in RA should take into account the prognostic factors of age, sex and duration of disease. | |
| 3238356 | IgA and IgM rheumatoid factors as markers of later erosive changes in rheumatoid arthritis | 1988 | Stored samples from within the first year of disease of 119 patients with rheumatoid arthritis (RA) enrolled in a long-running prospective study have been studied for the presence of IgM and IgA rheumatoid factors (RF), using agglutination of rabbit IgG-coated red blood cells to detect IgMRF and an ELISA technique using rabbit IgG coated on the microtitre plates and labelled F(aB)2 fragment of goat anti-IgA. Outcome measures at a mean follow-up of 10.1 years (range 3-20) included the Steinbrocker functional grade and grading of erosive changes on hand and feet Xrays using a modification of Lawrence's method. Both IgA and IgG levels at presentation correlated significantly with outcome measured by erosive changes and functional grade at a mean of 10 years and with the time of first appearance of erosions. In patients who are IgMRF negative early in the disease, IgARF positivity indicates a greater chance of developing both erosions and impaired function than when both tests are negative. IgARF positivity seems to precede IgMRF. | |
| 2915740 | Mesangial glomerulopathy and IgM rheumatoid factor in rheumatoid arthritis. | 1989 | Hematuria and proteinuria in rheumatoid arthritis (RA) are commonly associated with drug therapy but occur independently of drugs, amyloid or urologic disorders. The latter occurrences suggest a primary renal lesion associated with RA. Review of reported renal biopsies identifies mesangial glomerulopathy as a common finding in RA patients without associated drug therapy and that it is frequently associated with hematuria in nonrheumatoid patients. Moreover, immunoglobulins have been shown to concentrate in the mesangium in experimental animals, suggesting that a functional response by the kidney mesangium to remove IgM rheumatoid factor (RF)-IgG complexes could lead to this mesangial lesion. We describe 3 patients with RA who had a mesangiopathy characterized by increased quantities of mesangial matrix and deposition of IgM without other lesions. Together, these observations suggest that: (1) mesangial glomerulopathy is common in RA; (2) removal of circulating RF-IgG complexes is a function of the mesangium and might produce this renal lesion; (3) mesangial glomerulopathy may be responsible for much of the hematuria observed in RA patients and, in many cases, may not be drug related and thus may not require discontinuing beneficial therapy. | |
| 1870864 | [Analysis of radiographic changes in the cervical spine in rheumatoid arthritis]. | 1991 Aug 18 | At the outpatient department of rheumatology 100 patients having definitive or classic rheumatoid arthritis (RA) were examined and their cervical spine was radiographed with traditional X-ray technique. Correlation between roentgen signs and some parameters of the patient and of the disease was processed by regression analysis. The presence of the rheumatoid factor and second line drug therapy did not influence radiographic changes. Degenerative roentgen signs showed a linear correlation with the RA functional capacity and the duration of cervical complaints, and an exponential correlation with the duration of disease and the age of the patient. There was a linear correlation between osteoporosis and all the parameters examined. Inflammatory radiographic changes showed an exponential correlation with functional capacity and duration of cervical complaints, and a linear correlation with the duration of illness and the age of the patient. Symptoms of patients never treated with steroids was more severe than of those receiving short steroid therapy, but less serious than of those who had taken steroids for a long time (for longer than 10 years). | |
| 2494956 | Impaired delayed type cutaneous hypersensitivity in rheumatoid arthritis reversed by chrys | 1989 Feb | A prospective 24 week study of 31 patients with active rheumatoid arthritis (18 women, 13 men) was undertaken to determine whether weekly intramuscular sodium aurothiomalate (gold) would influence delayed type cutaneous hypersensitivity (DTH) and other indices of cell mediated immunity. DTH to seven recall antigens was measured by Multitest on three occasions during the study. Twenty five patients completed the study. At entry 13 patients (12 female) were anergic, and no significant correlations were found between DTH and other clinical and immunological indices. Women showed a significantly greater depression of DTH than men. At week 24 only three of the patients were anergic with significant increase in mean DTH score being noted particularly to tuberculin, candida, and streptococcus. Improvement in DTH was observed in both gold responders and non-responders. In conclusion, patients with active rheumatoid arthritis show impairment of DTH, which is reversed by chrysotherapy. This effect is most apparent in women and appears to be relatively independent of the clinical response. | |
| 1787504 | Iliolumbar ligament ossification as a radiologic feature of reactive arthritis. | 1991 Nov | We describe the case of a 21-year-old woman with the clinical picture of HLA-B27+ reactive arthritis (ReA) in whom the ossification of the left iliolumbar ligament was detected. Our case proves that ligament calcifications, which have so far been ascribed to diffuse idiopathic skeletal hyperostosis may also occur in young patients with ReA not primarily affected by metabolic osteoarticular diseases with negative family history. | |
| 3791753 | The energy cost of walking with arthritis of the hip and knee. | 1987 Jan | The physiologic energy expenditure of walking was measured in patients with severe arthritis. Nine patients were tested following Girdlestone hip resection arthroplasty, six patients prior to total knee arthroplasty (TKA) for unilateral osteoarthritis of the knee, and 49 rheumatoid arthritis patients prior to unilateral TKA; 27 were retested after operation. The results were compared with previously published pre- and postoperative data for total hip arthroplasty (THA) following primary osteoarthritis. There were severe energetic penalties caused by rheumatoid or osteoarthritis involving the hip or knee or following Girdlestone arthroplasty. Walking speed was severely reduced in all groups (range, 33-46 m/minute). The rate of oxygen consumption was not significantly greater than the mean rate of oxygen uptake for normal subjects; however, the oxygen cost per meter travelled was elevated because of the slow walking speed. The heart rate was significantly elevated in all patient groups. The elevated cardiac response can be accounted for on the basis of deconditioning resulting from the patients' pain, limited ambulatory activities, and the systemic effects of rheumatoid disease. In addition, the elevated cardiac response may be caused by added physical exertion by the arms in patients on crutches or walkers. The improvements in speed and energy cost were the same for the group of rheumatoid patients tested after unilateral TKA as in the group of patients tested before and after THA. The clinician can anticipate the same magnitude of improvement from surgery in a rheumatoid patient as in an osteoarthritis patient if the primary joint disease is restricted to a single joint. | |
| 3401058 | Response of rheumatoid arthritis to chemotherapy for Hodgkin's disease in a patient with I | 1988 Jul | A patient with IgA deficiency presented with classical rheumatoid arthritis (RA) and subsequently, features of multiple other connective tissue diseases (CTD). When Hodgkin's disease later developed the patient received combination chemotherapy, which induced remission of both neoplastic and connective tissue diseases. As the RA remained in remission for three years this case may offer insight into a mode of use of cytotoxic agents in CTD. | |
| 1795313 | Longterm treatment of rheumatoid arthritis with OM-8980. A retrospective study. | 1991 Dec | OM-8980 is an immunomodulating drug which has been shown in double blind placebo controlled trials to be effective in the management of rheumatoid arthritis (RA). For this report, longterm information was collected from 32 patients (27 women, 5 men) with RA who had been treated for periods ranging from one to over 8 years with OM-8980 daily (median 5 years). Statistically significant reductions were observed in duration of morning stiffness, articular index, pain and erythrocyte sedimentation rate (ESR). An improvement or strong improvement in overall condition was noted in 23 patients. Adverse events were reported in only 3 patients and were minimal in nature. Our study demonstrates that OM-8980 is an effective longterm slow acting antirheumatic drug which has minimal adverse effects and should be considered to have a role to play in the management of RA. | |
| 2665756 | Sensitivity of a health status measure to short-term clinical changes in arthritis. | 1989 Jul | To assess the sensitivity of the Arthritis Impact Measurement Scales (AIMS), we analyzed data from 3 clinical trials. One trial involving 255 patients with rheumatoid arthritis (RA) was a 12-week, randomized controlled trail of diclofenac, naproxen, and aspirin. Two trials were open-label studies of 24 weeks duration that included 165 RA and 355 osteoarthritis (OA) patients, all of whom were treated with diclofenac. In addition to the AIMS, tender joint count, morning stiffness, and erythrocyte sedimentation rate were used as outcome measures in the trials. The AIMS results showed substantial improvements in Physical Function, Psychological Status, and Pain, as well as in overall Arthritis Impact. These improvements were detected by the time of the initial outcome assessment at 4 weeks or 8 weeks, and were detected in patients with either OA or RA. These AIMS results closely parallel improvements shown by traditional clinical measures, and demonstrate that the AIMS health status measure is sensitive to improvements in OA as well as in RA. The AIMS also detects responses produced by therapy with nonsteroidal antiinflammatory drugs (NSAIDs), and these improvements can be demonstrated in as short a treatment time as 4 weeks. These findings confirm the utility of the AIMS for assessing outcome in rheumatic disease studies, and they have implications for the design of future clinical trials of NSAIDs. | |
| 2958011 | Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis. | 1987 Aug | New monoclonal antibodies allow CD4 lymphocytes to be categorized into helper/inducer (HI) CD4+ 4B4+, and suppressor inducer (SI) CD4+ 2H4+ subpopulations. Blood and synovial lymphocytes from 30 patients with rheumatoid arthritis (RA), 13 patients with other articular diseases, and 24 control subjects were exposed to these monoclonal antibodies and analyzed by flow cytometry. CD4:CD8 ratios were similar for the 3 groups. In RA patients, there was a depletion of SI cells in blood and synovial fluid, and the ratio of HI cells to SI cells was elevated, particularly in the synovial lymphocytes. These data provide new evidence for T cell dysregulation in the perpetuation of RA. | |
| 1927045 | [Arthritic pathogenicity of Mycoplasma and Mycoplasma arthritis in humans]. | 1991 | The review deals with Mycoplasma-induced arthritis. It provides the author's own results and the data available in the literature, which suggest that "arthritogenic" Mycoplasma make an etiological contribution to the development of human rheumatic arthritis. It also discusses some well-known and hypothetic mechanisms responsible for the pathogenesis of Mycoplasma-induced arthritis. | |
| 3207389 | Haematuria in rheumatoid arthritis: a follow up study. | 1988 Dec | Twenty one patients with seropositive rheumatoid arthritis and previously documented isolated haematuria were recalled at a median 7.7 years (range 3-12) after initial investigation. Eighteen subjects had previously undergone renal biopsy, which had shown mesangial glomerulonephritis in all but four cases. Renal function was found to have remained normal in all patients with previous mesangial changes despite the presence of persistent haematuria in most cases. | |
| 3767630 | Serratus anterior disruption: a complication of rheumatoid arthritis. | 1986 Oct | Pathology influencing the serratus anterior muscle contributes to classical medial winging of the scapula. Serratus anterior weakness or injury interferes with regular shoulder movement as this muscle stabilizes the medial border of the scapula against the thorax and rotates the scapula upward and laterally with arm elevation. Traumatic injury to the serratus anterior muscle without electrodiagnostic evidence of neurogenic involvement has only been reported once previously. We report an unusual case of disruption of the serratus anterior as a complication of rheumatoid arthritis. Involvement of the long thoracic nerve was ruled out by electromyography and nerve conduction studies. The injury occurred during routine activities of daily living and was complicated by a recurring subscapular hematoma. Contributing factors of shoulder joint contractures and coagulation abnormalities were associated with the course and treatment of rheumatoid arthritis. Initial treatment was by joint immobilization and reversal of coagulation abnormalities. Later treatment was directed toward joint protection and gradually increasing range of motion exercises. | |
| 3108634 | Rheumatoid arthritis: a disturbance in copper homeostasis. | 1987 Mar | That understanding the mode of action of antirheumatic drugs could help understand the etiology of rheumatoid arthritis is complicated by their apparent different actions on different target cells. The point of view adopted here is that the primary defect in rheumatoid arthritis will be similarly altered by such drugs. The common reactivity of two of the most widely prescribed drugs, D-penicillamine and sodium aurothiomalate, toward albumin-bound copper is proposed as their primary site of action. Elevated serum concentration of this form of copper has previously been suggested to perturb synovial cell metabolism and trigger the disease. |