Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2746584 | Protective HLA-DR phenotypes in rheumatoid arthritis. | 1989 Apr | In a study of HLA-DR phenotypes in patients with rheumatoid arthritis (RA) and controls from the Saskatoon area and in Newfoundland, we found that certain phenotypes occurred more frequently in the patients than in healthy controls in both populations ("increased risk phenotypes"). The reverse was also true: certain phenotypes were reduced or excluded from patients with RA compared with controls. Three increased risk phenotypes with twice the expected frequencies or more were HLA-DR1,DR4; DR4 and DR4,DR5. Four "protective" phenotypes with half or less the expected frequencies were HLA-DR1, DR5; DR2; DR2,DR3 and DR3,DR7. We speculate that at least for the DR3,DR7 phenotype, the protective effect may be due to a hybrid DQw2 molecule. | |
| 3264891 | [Audio-vestibular changes in patients with rheumatoid arthritis]. | 1988 Dec | A functional audio-vestibular investigation based on impedance metric techniques and electronystagmography was carried out in a group of patients with "classical" rheumatoid arthritis (RA) and with treated or untreated "definite" RA in various stages. Data obtained from these patients were compared with those obtained from a control group. Significant hypoacusis of the transmissive type was found in initial stages of RA while sensorineural or mixed type hypoacusis was found in later stages of RA. Significant vestibular alterations of the central type suggesting supratentorial involvement were found in several cases independently of the stage of RA and of the age of the patients. | |
| 2424642 | A case of rheumatoid arthritis with various enzyme-immunoglobulin complexes. | 1986 May 30 | Several complexes of enzymes and immunoglobulins were detected at the same time in the serum of a patient with seropositive rheumatoid arthritis. The enzymes which were found to complex with immunoglobulins were lactate dehydrogenase, alkaline phosphatase (liver, bone, placental, and intestinal isoenzymes), amylase, cytosol leucine aminopeptidase, and microsomal leucine aminopeptidase. Reconstitution studies after papain or pepsin digestion showed that the association site of the enzymes was in the Fab portion of the immunoglobulin component. We found these complexes to be the result of an antibody-antigen reaction. The binding capacity of each enzyme was variable over the entire time course. The patient's immunoglobulins, complexed with lactate dehydrogenase or amylase, could not be reconstituted using alkaline phosphatase, cytosol leucine aminopeptidase, or microsomal leucine aminopeptidase in vitro. Therefore, this suggests that the immunoglobulins which bind to each enzyme are independent of each other. | |
| 3473615 | Analysis of cellular and membrane extracts of human leukocytes from rheumatoid arthritis p | 1986 | Peripheral blood leukocytes from 30 patients with classic or definite rheumatoid arthritis (RA) and 18 healthy controls were separated into lymphocytes, monocytes and granulocytes and labelled with 35S-methionine. The integral membrane proteins with an amphiphilic nature were separated from hydrophilic proteins by use of the nonionic detergent Triton X-114. Both whole cells and membrane proteins were isotope labelled and separated by high resolution two-dimensional electrophoresis under denaturing conditions. Polypeptide spots were visualised by autoradiography. No consistent differences were found when leukocytes from RA patients were compared to the controls. | |
| 3278694 | Pulse steroid therapy in rheumatoid arthritis: can equivalent doses of oral prednisolone g | 1988 Jan | Pulse methylprednisolone therapy has dramatic effects on clinical and immunological parameters of disease activity in patients with rheumatoid arthritis. Previous studies of this treatment have all used the intravenous route and methylprednisolone succinate. This study addresses the question of whether oral prednisolone in equivalent doses can substitute for intravenous methylprednisolone in pulse therapy in a double blind parallel study. It is shown that oral prednisolone has clinical and immunological effects equivalent to those of intravenous methylprednisolone, making it possible to administer pulse therapy to patients with rheumatoid arthritis as outpatients without the inconvenience and inherent dangers of intravenous administration. | |
| 3476632 | Overview of Sjögren's syndrome. | 1987 Feb | Sjögren's syndrome, a chronic inflammatory and autoimmune disorder (Shoenfeld and Schwartz, 1984; Smith and Steinberg, 1983), is characterized by diminished lacrimal and salivary gland secretion (sicca complex), resulting in keratoconjunctivitis sicca (KCS) and xerostomia. As originally described, the syndrome consisted of a triad of dry eyes, dry mouth, and rheumatoid arthritis. We now know that other connective tissue diseases (e.g., systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis) may be present in place of rheumatoid arthritis, and that the sicca complex can exist as a primary pathologic entity with no associated disorder (Strand and Talal, 1980; Talal, 1985). Moreover, generalized lymphoproliferation, pseudolymphoma, or even lymphoid malignancy may appear in some patients (Talal and Bunim, 1964; Talal et al., 1967). More than 90% of patients are women, with a mean age of 50 years at diagnosis. The disease occurs in all races and all ages. | |
| 2449305 | Antibodies to basement membrane proteins nidogen and laminin in sera from streptococcal-re | 1987 Dec | Using the ELISA technique, antibodies against two different basement proteins, laminin and nidogen (ALNA), were determined in 226 children suffering from one of 37 different inflammatory or infectious diseases. These included 80 patients with streptococcal infection and 40 with juvenile rheumatoid arthritis. Forty-eight percent of the streptococcus-infected patients (or 75% of those in the acute phase) and 60% of juvenile rheumatoid arthritis patients had significantly elevated ALNA levels compared with healthy controls. Interestingly 10 adult rheumatoid arthritis patients displayed normal ALNA levels, suggesting a particular immune process occurring in children affected by juvenile rheumatoid arthritis. By means of periodate oxidation and glycosidase treatments we have shown that ALNA positive sera recognized terminal alpha-galactose as the reactive epitope. | |
| 3595079 | Radiographic image analysis in the study of bone morphology. | 1987 May | Early changes in bone morphology, arising from such conditions as rheumatoid arthritis and osteoarthritis, are difficult to detect and even more difficult to quantify when estimates are based upon visual examination of conventional radiographs. In this paper, we describe in detail the software operations of a computer-based image analysis system that will readily detect small changes in periarticular bone contours. Detailed studies have shown that the system compares favourably with clinical evaluations, and that the results so obtained are both reliable and reproducible. | |
| 1890163 | Rheumatoid factor (RF) distribution in periodontal disease. | 1991 May | This study investigated the occurrence of an autoantibody, IgM rheumatoid factor, that may result from the chronic inflammation noted in periodontal disease and rheumatoid arthritis. In order to detect IgM-RF, a biotin-avidin ELISA was developed. This assay was found to be sensitive and accurate by testing a rheumatoid arthritis population. The characteristics of this rheumatoid arthritis group were further determined, such that the total serum immunoglobulin concentrations were slightly elevated although within the normal range for IgM, IgG, and IgA; IgG antibody levels were elevated against oral microorganisms of the genus Capnocytophaga, while elevated IgM antibody levels were noted to Bacteroides species. In a population of 260 subjects of which 171 were periodontal disease patients, 16 of 171 (9.4%) were seropositive for IgM-RF, of which the predominant disease types were advanced destructive periodontitis and adult periodontitis. For comparison, a random population of seronegative periodontal disease patients was constructed that was matched for sex and approximate age to the seropositive group. The total immunoglobulin levels of the two groups were not significantly different and the means of both were slightly lower than the rheumatoid arthritis group. When the antibody profiles of the two periodontal disease populations were compared it became evident that the RF-positive group showed IgM and IgG antibody that was significantly elevated to Capnocytophaga species and F. nucleatum. Therefore, the chronic inflammation associated with periodontitis appears to increase significantly the formation of IgM-RF; however, there does appear to be a relationship between IgM-RF and elevated antibody to selected oral microorganisms. | |
| 3120055 | A tricky trigger finger: a patient with intermittent intrinsic locking of a metacarpophala | 1987 Oct | A trigger finger is not always caused by a stenosing tenosynovitis, but may rarely be due to an internal derangement of the metacarpophalangeal (MCP) joint. Several different mechanisms may be responsible for this intrinsic joint locking. A patient is described with intermittent locking of an index MCP joint due to an osteophyte tethering the radial accessory collateral ligament. Removal of the osteophyte solved the problem. Awareness of this condition may prevent unnecessary exploration of the proximal pulley and tendon sheath. | |
| 2323479 | Vascular changes in peripheral corneal destructive disease. | 1990 | A clinical classification of peripheral corneal destructive disease is presented. These syndromes all start within 2 mm of the limbus and are accompanied by varying degrees of vaso-occlusion of the adjacent limbal vascular networks. Close observation of the configuration, integrity and pattern of the limbal vessels can indicate whether the disease is active, quiescent or brought under control with treatment. | |
| 1959293 | The Total Condylar III prosthesis in complex knee reconstruction. | 1991 Dec | Sixty-one Total Condylar III (TC III) prostheses were implanted in 59 patients at the authors' institution between March 1977 and December 1987. Among the knees with adequate clinical and roentgenographic data, the average follow-up period was 6.1 years. There were six primary arthroplasties and 29 revisions in this group. The primary diagnosis was osteoarthrosis in 17 patients, rheumatoid arthritis in 16 patients, and juvenile rheumatoid arthritis in two patients. The knee score improved from 21.9 preoperatively to 73.7 at last follow-up evaluation. Based on the knee score, there were 71% good or excellent results. There were three failures (8.6%). Radiolucent lines were present in at least one component in 71% of patients, but few of these were considered significant. Although rarely needed, the TC III prosthesis has been shown to be a satisfactory and durable solution to complex knee reconstructive problems including severe deformity, ligamentous instability, and bone loss. | |
| 3422170 | The oncogenicity of chlorambucil in rheumatoid arthritis. | 1988 Feb | Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent. A retrospective survey was performed to assess the incidence of all types of malignancy in 39 patients treated with chlorambucil (mean daily dose 4.25 mg, mean duration of treatment 25 months). These patients were compared with 30 patients with RA who received contemporaneously, the purine analogues azathioprine or 6-mercaptopurine (mean dose 100 mg, mean duration of treatment 24 months). Eight patients treated with chlorambucil and one patient receiving purine analogues developed cutaneous malignancy (p = 0.03). In the chlorambucil-treated patients these were mostly multiple and recurrent. Three patients treated with chlorambucil developed myeloid leukaemia or a preleukaemic state, whilst no patient treated with purine analogues developed this complication. The use of chlorambucil in RA is associated with an increased risk of cutaneous as well as haematological oncogenesis. | |
| 2420498 | Electrophoretic transfer blotting analysis of immune complexes in rheumatoid arthritis. | 1986 Jan | Immunochemical analysis of immune complexes (IC) derived from synovial fluid and serum of patients with rheumatoid arthritis (RA) was undertaken. IC were isolated by differential polyethylene glycol precipitation and competitive binding to staphylococcal Protein A. Anti-IC antisera were raised in rabbits by immunization with purified IC. IC were characterized by SDS-polyacrylamide gel electrophoresis (SDS-PAGE), electrophoretic transfer to nitrocellulose sheets, reaction with either anti-IC antiserum or monospecific antiserum against putative components, then developed with 125I-Protein A and autoradiography. Synovial fluid IC from both RA and control inflammatory joint diseases contained immunoglobulin light chains, and mu and gamma heavy chains. IC from RA synovial fluid also contained alpha chain, and Clq. Cross-over studies of IC and antisera revealed cross-reactive antigens in IC of RA synovial fluid and that remained unidentified were of the following relative molecular masses: 26,000; 39,000; 40,000; and 43,000. Studies using early and late serum samples to probe the blotted IC failed to disclose serological autoreactivity. This sensitive analytical technique provides a means for detailed description of the constituents of IC in inflammatory joint diseases. | |
| 3489468 | Cryoglobulinemia in autoimmune rheumatic diseases. Evidence of circulating monoclonal cryo | 1986 Sep | The incidence and nature of cryoglobulins, as well as their correlation with the clinical and serologic picture of Sjögren's syndrome (SS), were studied in the sera of 30 consecutive primary SS patients. Sera from 29 patients with systemic lupus erythematosus, 58 patients with rheumatoid arthritis, and 125 healthy blood donors were also studied. It was shown that one-third of the patients with SS had cryoglobulinemia. These cryoglobulins were mixed monoclonal IgM immunoglobulins, whereas those observed in systemic lupus erythematosus and rheumatoid arthritis patients were mixed polyclonal. The nature of the cryoglobulins was demonstrated using high-resolution electrophoresis combined with immunofixation. The presence of cryoglobulins in the sera of SS patients correlated with extraglandular disease and with antibodies to Ro (SS-A) and IgM rheumatoid factor. SS patients with cryoglobulins had lower serum C4 levels than did patients without cryoglobulins. These findings suggest that SS expresses, in addition to polyclonal B cell hyperreactivity, a monoclonal process in the absence of lymphoid neoplasia. Further, they show that the extraglandular manifestations of the syndrome may be due to an immune complex-mediated pathology. | |
| 2226086 | Retroperitoneal air after routine hemorrhoidectomy. Report of a case. | 1990 Nov | Retroperitoneal air as a complication after routine hemorrhoidectomy has not been reported in the literature. This occurred recently after hemorrhoidectomy in a 34-year-old patient receiving glucocorticoid therapy for rheumatoid arthritis. Adverse steroidal effects of wound healing have been well documented. It is believed that steroid-induced tissue changes contributed to the development of this unique complication. | |
| 2591396 | Penicillamine-induced polymyositis with complete heart block. | 1989 Nov | Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis. After drug withdrawal the muscle enzymes and the cardiac rhythm gradually normalized, only leaving a right bundle branch block. Although this is the first report to show that severe cardiac damage associated with penicillamine-induced polymyositis is a potentially reversible condition, the severity of the three cases reported so far warrants close observation for cardiac involvement in patients with penicillamine-induced polymyositis. | |
| 2838438 | Determination of gold accumulation in human tissues caused by gold therapy using x-ray flu | 1988 | Human autopsy tissues from five patients with rheumatoid arthritis, who had been treated with aqueous solutions of gold and from an untreated control cadaver with the same disease, were analysed by x-ray flurescence spectrometry using a conventional Si(Li) detection system. The gold and zinc concentrations of tissues were determined and compared to some results available in the literature. Correlation has been found between Zn and Au concentrations in heart, lung, kidney and liver tissues. | |
| 3337931 | District rheumatology services. A report by the Committee on Rheumatology of the Royal Col | 1988 Feb | The Committee on Rheumatology was seriously concerned about variations in the availability of services for patients with rheumatic diseases in different parts of the country. It commissioned a draft report to document various aspects of the present situation which would then be augmented, on this basis, by proposals for the establishment of basic requirements and minimum standards for a district rheumatology service. The draft was considered and adopted, and the report has now been approved by the Royal College of Physicians of London; in its final form it is now an official College document. This paper sets out the contents of the report endorsed by the College Committee. | |
| 2716005 | Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid art | 1989 Jan | The carbonyl content of proteins in the synovial fluid (SF) of patients with rheumatoid arthritis was significantly (p less than or equal to 0.10) elevated over levels in the SF of patients with osteoarthritis (OA). Other indicators of oxidative damage including catalse, ceruloplasmin, ferritin and superoxide dismutase also showed statistically significant differences (p less than or equal to 0.05) compared to patients with OA. |