Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1972308 | Suppression of experimental autoimmune encephalomyelitis by sulfasalazine. | 1990 Mar | It has recently been suggested that the sulfidopeptide leukotriene C4 (LTC4), a 5-lipoxygenase product of the arachidonic acid metabolism and one of the most potent mediators of vascular permeability, might be involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). Subsequently, 20 guinea pigs with EAE were treated with sulfasalazine, a substance with a proved leukotriene inhibiting effect, which has previously been described as exerting beneficial effects in patients with inflammatory bowel disease and rheumatoid arthritis. The sulfasalazine-treated guinea pigs showed a significantly better clinical outcome, as well as a significantly lower histological inflammation score compared with 19 controls. | |
| 2091685 | New enzyme-linked immunosorbent assay methods for measurement of serum erythropoietin leve | 1990 | For clinical studies with erythropoietin (EPO), enzyme-linked immunosorbent assays for the determination of EPO and EPO antibodies were developed. Using polyclonal and monoclonal EPO antibodies in a sandwich technique, serum EPO levels greater than 10 pg/ml (corresponding to 1 mU/ml, calibrated with the 2nd WHO IRP EPO) can be determined. In 103 healthy blood donors, a mean (+/- SD) value of 36 +/- 19 pg EPO/ml was found. Very high EPO concentrations were found in patients suffering from myelodysplastic syndrome and aplastic anemia; elevated levels were associated with rheumatoid arthritis and myelomatosis. No EPO antibodies were detectable in EPO-treated patients. | |
| 2519162 | [Clinical experience with etretinate (Tigason) in 26 patients with psoriasis]. | 1989 May | The effect of etretinate was evaluated in 26 patients with psoriasis unresponsive to conventional therapy. Twenty patients had the common variety of the disease, 3 had inverse psoriasis, 2 had arthropathy and 1 had plantar psoriasis. In addition, 17 patients had nail involvement. The drug was started at dose of 0.6 mg/kg/day; and was adjusted according to clinical response over a mean period of 6.8 months. Disappearance of the plaque occurred in 14 patients (54%) and remained stable for a mean of 7.3 months after therapy. Success rate was higher in patients with nail involvement (80%). Results were good in patients with arthralgia associated to hyperuricemia, psoriatic arthropathy and in one patients with rheumatoid arthritis. Mild effects of vitamin A toxicity were observed in 100% of cases. The drug was discontinued in 4 patients due to hypertriglyceridemia. | |
| 2642587 | Clinical and serologic characteristics of patients with overlap syndrome: is mixed connect | 1989 Jan | We discuss the clinical and serologic features of 27 patients with overlap syndrome followed prospectively by our group. The findings are similar to those of other reports, but we have drawn attention to the presence of peritendinous nodules in these patients and mentioned some peculiar neurologic manifestations. Rheumatoid arthritis was the most common diagnosis in our patients. The presence of high-titer antibodies against the nuclear ribonucleoprotein fraction of extractable nuclear antigen (nRNP) did not allow the identification of a particular subgroup. However, patients with this antibody tended to fulfill more criteria of more diseases than those without it. The findings lead us to conclude that antibodies to nRNP do not identify a particular subgroup within the overlap syndromes and that mixed connective tissue disease does not appear to be a distinct entity. | |
| 3041835 | Idiopathic multicentric osteolysis: report of two new cases and a review of the literature | 1988 Apr | Idiopathic multicentric osteolysis is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bones usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of this syndrome. Mental retardation and minor facial abnormalities have been noted in some patients. We report on 2 unrelated, sporadic cases, one with facial anomalies and the other with nephropathy. Our second patient is the first black child to be diagnosed with this disease. The mode of presentation, differential diagnosis, and natural history of this disorder are briefly reviewed. | |
| 3410657 | Psychosomatic disorders in psychiatric patients in a developing country. | 1988 Summer | This study reports the prevalence of psychosomatic disorders in psychiatric patients in India. The psychosomatic disorders studied were hypertension, peptic ulcer, bronchial asthma, rheumatoid arthritis, ischaemic heart disease and chronic pain. 21.5% of psychiatric patients had psychosomatic illnesses. Fifty five cases had two psychosomatic illnesses. Chronic pain (14.4%) and hypertension (9.9%) were the commonest. Patients with psychosomatic disorders were significantly more often older in age, females, married and from an urban habitat. Neurotic illness was the commonest diagnosis in them. Psychosis was significantly and inversely associated with psychosomatic disorders. This report emphasises the need for as much attention on psychosomatic problems in developing countries as in affluent ones. | |
| 3291096 | Physical disease and schizophrenia. | 1988 | Researchers have long speculated about the existence of a relationship between physical disease and schizophrenia. Psychodynamic and life-stress theories offer opposing predictions about the nature of this relationship. Unfortunately, the empirical research on this topic is often contradictory and frequently plagued by various methodological inadequacies. Despite the theoretical controversy and methodological problems, the present review of the empirical literature suggests that patients with schizophrenia may be at increased risk for breast cancer and possibly for cardiovascular disease. On the other hand, patients with schizophrenia seem to be at reduced risk for developing either rheumatoid arthritis or lung cancer. The epidemiological investigations are worth pursuing since the convincing demonstration of a relationship between schizophrenia and a particular physical disease would yield valuable information about the pathogenesis of both disorders. Future research on this topic will need to consider the possible mediating effects of third variables, such as smoking habits, which may be associated with schizophrenia and which also are, independently, recognized as risk factors for particular physical disorders. | |
| 3209076 | Circumferential nodulocystic keratopathy. A case report. | 1988 | An apparently unique type of corneal nodular keratopathy is presented. The keratopathy was characterized by large, circumferentially bilaterally located, cystic nodules just inside the limbus. No epithelial cell or collagenous degeneration nor evidence of chronic inflammatory process was found on histopathologic examination of a biopsy of a nodule. Proteinaceous material was present between the epithelial cell basement membrane and collagenous stroma. There was no antecedent history of keratitis or uveitis. The patient was known to have inflammatory bowel disease (regional ileitis) and rheumatoid arthritis with ankylosing spondylitis. However, the corneal lesions could not definitely be associated with any of these disorders. This case does not correspond with any previously described corneal disorders. We have termed it circumferential nodulocystic keratopathy, which best describes its clinical and histologic features. | |
| 3307356 | Sonography of thigh abscess: detection, diagnosis, and drainage. | 1987 Oct | Sonographic characteristics and percutaneous catheter drainage of thigh abscesses in 18 patients are described. Most of these patients had underlying diseases including osteomyelitis, trauma, diabetes mellitus, rheumatoid arthritis, leukemia, lymphoma, sepsis, bleeding dyscrasia, and autoimmune disease. Previous procedures on these thigh collections included seven operations and 12 nondiagnostic ward aspirations. All collections were shown by sonography to be either anterior or anterolateral. Two cases referred for drainage were posteromedial; sonography showed these to be mycotic pseudoaneurysms. The abscesses were either anechoic or hypoechoic, and occasionally had debris and septations. Abscesses associated with underlying osteomyelitis abutted the femur; those related to other causes generally were more superficial within muscle or fascial layers. Sonographically guided catheter drainage successfully cured all patients, even those in whom ward aspiration or formal surgery had been unsuccessful. Sonography is a simple and inexpensive method of imaging and guiding the drainage of thigh abscesses. Percutaneous catheter drainage is the treatment of choice in cases in which simple emergency room or ward incision and drainage are inadequate. | |
| 3586692 | The effect of an oral gold preparation on the gastrointestinal tract motility in two speci | 1987 Apr | The oral gold preparation, auranofin, used in rheumatoid arthritis has been reputed to cause chronic diarrhea. To investigate this the G.I. tract motility was measured before auranofin therapy and after 1, 3, and 5 weeks of therapy using scintigraphy following indium-111-labeled meals in three beagle dogs. The gastric emptying times of the dogs accelerated throughout the duration of the experiment, although the large bowel transit times did not seem to be affected. The affect of auranofin on the stools of the baboon Papio ursinus was also noted. The baboon stools were observed for any change in consistency. Sigmoidoscopic examination including mucosal biopsies was carried out monthly over a 6-month period. The baboon's stools were noted to become very soft in consistency, but histology indicated no mucosal changes. | |
| 2885415 | Effects of auranofin and other antirheumatic drugs on human myelopoiesis in vitro. | 1987 Apr | Leukopenia is one of the more serious side effects of auranofin (AF) therapy for rheumatoid arthritis. AF and its deacetylated form inhibited the development of macrophage and granulocytic colonies from progenitor cells in human bone marrow even at concentrations less than or equal to 10(-9)M. The disease suppressive activity of AF could result in part from the reduction of cell numbers in arthritic lesions and our findings provide a mechanism for this possibility. In contrast, other slow acting antirheumatic drugs, sulfasalazine, chloroquine and hydroxychloroquine, show partial inhibition of colony development but at concentrations of the order of 10(-5)M. | |
| 3778178 | Trochanteric bursitis: a common clinical problem. | 1986 Nov | In 72 patients followed for two years, the diagnosis of trochanteric bursitis was based on precise clinical signs without significant contribution from laboratory tests or radiologic signs. In six of the patients (8.3%) the bursitis was an isolated condition of unknown origin. Six other patients had rheumatoid arthritis without involvement of the ipsilateral hip joint. The remaining 60 patients (83.4%) had pathologic conditions of the adjacent areas, such as symptomatic lumbar spine arthrosis or ipsilateral hip damage, conditions that often mask the actual source of pain and disability. A rapid and prolonged improvement of the pain and disability caused by the bursitis was achieved in all 65 patients (90.3%) treated by local corticosteroid and anesthetic infiltrations: in 48 patients after one, in 13 after two and in 4 after three local treatments. Local corticosteroid infiltration proved to be the treatment of choice as well as a diagnostic test. | |
| 3721202 | Dizziness, falling, and fainting: differential diagnosis in the aged (Part II). | 1986 Jul | Salicylates used for rheumatoid arthritis, or in inadvertently high dosages by patients themselves, often cause toxicity manifested by tinnitus, hearing impairment, and imbalance. Vestibulotoxic drugs should always be considered in older patients when the cause of imbalance is not apparent. Gait disturbance is an important presenting symptom of subdural hematoma, along with a fluctuating level of alertness. A high degree of suspicion is required to diagnose this treatable condition early. | |
| 3731718 | A preliminary evaluation of the dimensionality and clinical importance of pain and disabil | 1986 Jun | Current methods of clinical assessment in osteoarthritis show a high degree of variability. By contrast, patients with rheumatoid arthritis may be evaluated using a number of standardised and validated indices. One hundred patients with primary osteoarthritis of the hip and knee were interviewed in order to determine the dimensionality of their discomfort and disability and to define the clinical importance of each component item. The symptomatology of osteoarthritis was captured by five pain, one stiffness, twenty-two physical, eight social and eleven emotional items. In spite of a high degree of variability in the frequency of involvement of the individual items, their clinical importance was similar both within as well as across dimensions. Further studies are indicated to determine the reliability, validity and responsiveness of each of the items identified as a prelude to developing a standardized method of assessing patients with osteoarthritis of the hip and knee. | |
| 3604987 | Vasculitis in primary Sjögren's syndrome. Histologic classification and clinical presenta | 1987 Jul | Nine out of 70 patients with primary Sjögren's syndrome had vasculitis of small and/or medium-sized vessels. The small vessel vasculitis was of the hypersensitivity type: leukocytoclastic and lymphocytic. The medium vessel vasculitis was acute necrotizing and simulated polyarteritis nodosa histologically but lacked the characteristic aneurysmal formation. A healing stage of vasculitis, presenting as endarteritis obliterans, was seen in patients with Sjögren's syndrome and a long-standing history of vasculitis. The hypersensitivity vasculitis was localized mainly in the skin and provided mild clinical symptoms. The polyarteritis nodosa-like vasculitis was localized predominantly in internal organs and was associated with life-threatening symptoms. Endarteritis obliterans was mainly seen in acral sites of the extremities and presented with recurrent symptoms of obstruction. One patient died of vasculitis. The remaining patients are alive. The presence of anemia, cryoglobulinemia, and hypocomplementemia suggested an immune-complex origin of the vasculitic process. | |
| 1998399 | Types of atrophic gastritis in patients with primary Sjögren's syndrome. | 1991 Feb | Histological examination of the gastric mucosa was performed in 44 patients with primary Sjögren's syndrome with extraglandular symptoms (mean age 51.9, range 22-76). Biopsy specimens were taken from each of three separate regions: the antrum, the corpus, and the transitional zone between the antrum and the corpus. The incidence of chronic atrophic gastritis was considerably higher in patients with Sjögren's syndrome than in the controls. In the young patients with Sjögren's syndrome atrophic lesions were more common both in the antrum and in the corpus than in the control group. In middle aged patients, however, only the antrum, and in the elderly only the corpus, was much more commonly affected than in the controls. All three types of chronic atrophic gastritis occurred in patients with Sjögren's syndrome. Decreased gastric acid secretion was associated mainly with atrophic gastritis of types A and AB, whereas hypergastrinaemia occurred almost exclusively in gastritis of type A. | |
| 1771398 | Clinical features of patients with mild systemic lupus erythematosus. | 1991 | Clinical features of 16 patients with mild systemic lupus erythematosus (SLE) were compared with those of 21 control patients with moderate or severe disease. Age at the time of diagnosis of SLE was higher in mild disease group. The incidence of the coexistence of Sjögren's syndrome (SS) at the time of diagnosis of SLE was higher in patients who later developed mild disease. Anti-Sm antibody and decreased levels of C3, C4, and CH50 occurred less frequently in patients with mild disease. SLE patients with the coexistence of SS at the time of diagnosis of SLE may represent a subset with a benign prognosis. | |
| 2617229 | Sicca syndrome and anti-SSA/Ro antibodies in patients with suspected or definite multiple | 1989 | Thirty-eight consecutive patients with primary Sjögren's syndrome (SS) and 36 with suspected (15 cases) or probable to definite (21 cases) multiple sclerosis (MS) underwent thorough neuropsychiatric and rheumatological examinations in order to detect either the presence of central neurologic involvement in SS or the presence of clinical and immunologic abnormalities typical of SS in MS. The only neuropsychiatric abnormality we found in patients first recorded for primary SS was major depression in 5 cases. On the other hand, one patient with suspected MS because of mild gait ataxia and right hemiparesis fulfilled the diagnostic criteria for SS. As for serologic tests, 6 out of 21 patients with probable to definite MS and 1 out of 15 with suspected MS had low-titre antinuclear antibodies. One patient with definite MS had also circulating anti-SSA/Ro antibodies, detected by gel double diffusion, but did not develop sicca symptoms after a 2-year follow-up. In the present study, the association between SS and MS was considerably weaker than that recently reported in other studies, and might be regarded as a chance finding. | |
| 3948626 | Esophageal function, radiography, and dysphagia in Sjögren's syndrome. | 1986 Mar | Esophageal function and anatomy were investigated with manometry, acid perfusion test, acid clearing test, and x-ray in 11 patients with primary Sjögren's syndrome (SS) and in 11 with secondary SS. The manometric investigation revealed minor motor differences in the SS patients as compared to 16 controls, ie, shorter peristaltic contraction time of the whole esophagus, and faster peristaltic velocity preferably in the distal part of the esophagus, while the results from the reflux tests did not differ between patients and controls. Radiographic examination revealed upper esophageal webs in 10% (2/20), and hiatal hernia in 25% (5/20). The dysphagia as reported by 73% of the patients cannot be explained by webs or impaired motor function and is regarded to be secondary to lack of saliva, making the solid bolus passage difficult. | |
| 2033900 | [A case of diffuse panbronchiolitis complicated by malignant thymoma and Sjögren's syndro | 1991 Feb | A patient with diffuse panbronchiolitis (DPB) complicated by malignant thymoma and Sjögren's syndrome with pseudolymphoma is reported. A 58-year-old woman developed productive cough, dyspnea and sicca in the mouth. Laboratory findings on admission indicated a high titer of cold hemagglutinin, positive of anti-DNA and negative PPD skin test. Chest-X ray revealed diffuse reticulonodular shadows in the lower lung field and anterior mediastinal mass shadow. Pulmonary function studies showed reduction of the vital capacity, forced expiratory volume in one second, DLco and hypoxia (PaO2; 69.1 Torr). Lung biopsy and resection were performed. Histologically infiltration of mononuclear cells and accumulation of foamy cells around respiratory bronchioles and stenosis of terminal bronchioles by granulation tissue was compatible with the diagnosis of DPB and the mediastinal tumor appeared to be a malignant thymoma invading to pericardium. Focal infiltration of lymphocytes was also recognized around the salivary glands (Sjögren's syndrome) and in the alveolar septa (pseudolymphoma). This case of DPB might have been associated with lymphoproliferative disorders. |