Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1529284 | Effect of six months of fish oil supplementation in stable rheumatoid arthritis. A double- | 1992 | Therapeutic effects of fish oil (10 g/day) in rheumatoid arthritis were investigated in a randomized, controlled, double-blind study. Forty-three patients completing the study were evaluated at 0, 3 and 6 months. The nutrient intake in the fish oil group and in the control group was essentially similar. In the fish oil group, the percentage of n-3 fatty acids in serum phosphatidylcholine increased by 9.6 (range 2.6-16.1). Patients in the fish oil group reported a significantly decreased consumption of NSAID at 3 and 6 months, and the status of global arthritic activity improved at 3 months in physician's assessment. Control patients reported an increased global arthritic activity at 6 months. No change was found in patient assessment of pain, duration of morning stiffness or functional capacity. Essentially no change occurred in biochemical markers of inflammation. We conclude that fish oil has small anti-inflammatory effects with at most a NSAID-saving potential. The value of prolonged supplementation remains to be evaluated. | |
| 1588744 | [Surgical treatment of rheumatoid arthritis]. | 1992 Mar | Synovectomy, total arthroplasty and arthrodesis are the main surgical methods for rheumatoid arthritis. Although recurrent synovitis and radiological deterioration after synovectomy have been reported, the procedure can be an effective treatment if it is performed in the early stage where articular cartilage and bone are minimally damaged. Arthrodesis is indicated for severely destroyed joints. However, since loss of motion in the proximal joints often leads to severe disability, its indication is limited to the distal joints, such as the wrist and ankle. Total rthroplasty seems to be an ideal method because relief of pain and recovery of function can be obtained simultaneously. However, there are some complications, such as loosening and wear of the prosthesis. Solution of these would bring much benefit to the disabled rheumatoid arthritis patient. | |
| 1570492 | HLA haplotype sharing in rheumatoid arthritis sibships: risk estimates in siblings. | 1992 | The distribution of the number of parental HLA haplotypes shared by sibs with rheumatoid arthritis (RA) has been used to obtain information on the genetics of the disease. Thirty-four RA sibships (25 sib-pairs, 9 sib-trios) were ascertained, all of which were HLA typed and which satisfied the 1958 American Rheumatism Association criteria for "definite" RA. These were combined with other published but nonoverlapping data from the literature; thus, 143 sib-pairs, 36 sib-trios and 4 sibquads were identified. The affected RA sibs shared two, one and zero parental HLA haplotypes in a ratio of 40: 45: 15 which was significantly different from random expectations (p less than 0.05). Risk estimates for sibs of probands for those sharing two, one and zero parental HLA haplotypes were 6.2%, 3.5% and 2.3% respectively. Risks subdivided by DR genotype of the proband are also calculated, the highest (8.7%) being for sibs sharing two haplotypes with a proband carrying at least one DR4 allele. The manuscript also considers genetic information in relatives other than siblings; an extension of the affected relative pair haplotype sharing method to second and third degree kinships is presented. | |
| 7674226 | HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young | 1995 Jun | OBJECTIVE: To confirm the reported strong association between the HLA-DRB1*0401/0404 genotype and susceptibility to rheumatoid arthritis (RA), and to investigate the influence of sex, age at disease onset, and variables of disease severity on the strength of this association. METHODS: A case control design was adopted comparing the frequency of specific HLA-DRB1 genotypes between 201 Caucasian patients with RA and 139 controls. HLA typing was performed using a polymerase chain reaction based oligonucleotide approach with HLA-DR4 subtyping using an amplification refractory mutation system RFLP technique. RESULTS: The risk of RA in those carrying a single shared epitope (SE) allele was 4 times, and in those carrying 2 SE alleles, 8 times that in the SE negative individuals. This increase was highest in individuals carrying 2 different SE alleles, with the risk in *0401/*0404 cases being 26 times higher. This genotype was associated with a 90-fold increased risk in men and this was more than doubled when age at disease onset was below 30. In all patients with RA, this genotype was associated with a substantially increased risk of being rheumatoid factor positive and having subcutaneous nodules and/or radiological erosion. CONCLUSION: Possession of the HLA-DRB1*0401/*0404 genotype carries a substantially high risk for RA development specifically in its more severe forms. The risks are particularly increased in young men. | |
| 1582106 | Ulnar translation of the scaphoid: an early X-ray sign of rheumatoid arthritis. | 1992 Mar | The distance between the os trapezium and radius (which we called scaphoid distance) became shorter during the course of rheumatoid arthritis (RA). Measurement of this distance was performed in 600 hands (300 patients), using standard position of patient's hand in supination with permanent angle (15-20%) between the axis of the radius and the axis of the third metacarpal bone (scaphoid distance). This provided a stable distance between the most distal point of the radial styloid process and most proximal point of the os trapezium. The patients were divided into two groups: a control group consisting of 100 patients with no inflammatory joint disease, and a group of 200 patients suffering from RA. Patients suffering from RA with bone erosions had smaller scaphoid distance than those suffering from RA without bone erosions. The ratio between the distance from the distal radius to the most distal point of the third metacarpal bone and scaphoid index was called carpo-metacarpo-scaphoid index. It excluded the constitutional influence on the scaphoid distance. The shorter the scaphoid distance, the bigger the carpo-metacarpo-scaphoid index. The average indexes were: in the control group 7.8 (+/- 0.4), in group 2A with advanced RA 21.1 (+/- 4.1), and in group 2B with early RA without bone changes 12.0 (+/- 1.6). The results were statistically significant. The measurements are easy to perform and may be helpful in the early X-ray diagnosis of RA, when there are no bone erosions, or narrowing of articular spaces. | |
| 8658380 | Neurone-specific enolase levels in pleural effusions in patients with rheumatoid arthritis | 1996 Jan | BACKGROUND: High pleural fluid levels of neurone-specific enolase (NSE) have been reported, not only in patients with small cell lung cancer but also in those with chronic inflammatory diseases. METHODS: NSE concentrations were determined in pleural fluid and serum from 342 patients with pleural effusions including 17 with rheumatoid arthritis. RESULTS: The median NSE concentration in pleural fluid was higher in rheumatoid effusions than in any other condition studied. The median pleural fluid:serum NSE ratio was highest in patients with rheumatoid arthritis (11.6) and about unity in all other diseases including small cell lung cancer (0.9). In patients with rheumatoid arthritis pleural fluid concentrations of NSE correlated inversely with pleural fluid glucose concentrations and the pH of the pleural fluid. CONCLUSIONS: A high pleural fluid:serum NSE ratio was found consistently in pleural effusions from patients with rheumatoid disease. | |
| 1588733 | [Biotechnology for rheumatology researches]. | 1992 Mar | Recent developments in biotechnology include cellular engineering and molecular engineering. In order to further investigate several aspects of rheumatic diseases, it is necessary to know and apply these new techniques. They are, for example, monoclonal antibody productions, T cell lines, T cell hybridomas, gene cloning, Southern blot, Northern blot, recombinant protein productions and PCR. Out lines of these techniques are described. | |
| 1450509 | Rheumatoid nodules of the lung in a patient with palindromic rheumatism. | 1992 Jul | We report a case of rheumatoid nodules of the lung seen in a patient with palindromic rheumatism. A 54-year-old man with palindromic rheumatism was admitted for evaluation of three nodules in the right upper lobe on chest roentgenogram. Wedge resection was performed for the purpose of confirmative diagnosis and treatment. Histology of these lung lesions revealed palisaded histiocytic cells surrounding a layer of central necrosis, which were considered to be characteristic findings of rheumatoid nodule. Such a case is extremely rare. To our knowledge, only one other case has been reported before in the literature. | |
| 7674225 | Soluble class I HLA antigens in patients with rheumatoid arthritis and their families. | 1995 Jun | OBJECTIVE: To study Class I soluble HLA in black patients with rheumatoid arthritis (RA) and their families, and to compare the findings to a group of healthy families of the same racial background. METHODS: ELISA was developed measure soluble HLA Class I (sHLAI) in the serum of 25 patients with RA. Family studies were performed in seven patients with RA and their 28 first degree relatives. These family studies were compared to similar measurements for 66 members of 13 healthy families. RESULTS: Mean sHLAI values were higher in patients with RA than those observed in healthy black individuals. Patients with RA were characterized by elevated serum HLAI, while no change was observed between patients with RA positive or negative for rheumatoid factor. The relatives of patients with RA had high concentrations of sHLAI, compared to families without RA. Highest serum concentrations of sHLAI were found in individuals who were HLA-A23 or HLA-Aw33 positive. CONCLUSION: sHLAI may play a role in the pathophysiology of RA, and there is an association between either augmented release or production of sHLAI and specific HLA allotypes. | |
| 8720741 | Low dose corticosteroids in early rheumatoid arthritis. Can these drugs slow disease progr | 1996 Mar | The role of corticosteroids in treating rheumatoid arthritis is controversial, but recourse to the available evidence of efficacy should guide patient management decisions. Earlier evidence suggested that symptomatic control could be improved for periods of 6 to 12 months, but not longer, without increasing doses to unacceptably high levels. The effect of corticosteroids on joint destruction has been unclear. Recent findings from a controlled clinical trial show that prednisolone 7.5 mg/day can significantly retard the rate of erosive progression in patients with relatively early disease (< 2 years' duration). These results have implications for both disease management and our understanding of the pathogenesis of joint destruction in rheumatoid arthritis. | |
| 8167623 | [Rheumatoid arthritis and multiple myeloma. Apropos of 22 cases. Results of a multicenter | 1993 Apr | Although studies of patients with rheumatoid arthritis have found no increases in overall cancer rates, significant elevations in rates of lymphoma and myeloma have been reported, suggesting a causal relationship between autoimmune disorders and lymphoid malignancies. Nevertheless, only 22 cases of concomitant rheumatoid arthritis and multiple myeloma were identified during a retrospective national multicenter study carried out in France. Neither disease exhibited unusual features. In every case, rheumatoid arthritis preceded multiple myeloma. Monoclonal gammopathy preceded multiple myeloma in two patients, by 3 and 7 years respectively. No patient had amyloid arthritis. Analysis of data from the cancer registry of the Somme district in northern France did not suggest a significantly increased risk of multiple myeloma in rheumatoid arthritis patients (relative risk 2.3). Use of interferon alpha to treat myeloma has been reported to exacerbate concomitant autoimmune disorders. | |
| 1395217 | Tiopronine-induced reduction of rheumatoid factor functional affinity and asialylated IgG | 1992 Jul | Serum and synovial fluid (SF) from 16 rheumatoid arthritis patients were evaluated before and after a 2-month treatment with tiopronine (TP). The levels of rheumatoid factor (RF) declined, as did the functional affinity of the remaining RF (p less than 0.01 in serum and p less than 0.05 in SF). Concomitant restoration of the sialylation of IgG was observed (p less than 0.05 in serum and SF). Following an initial increase, a significant reduction was observed in the level of soluble interleukin-2 receptors in serum (p less than 0.05) and SF (p less than 0.05) after treatment with TP. | |
| 1575785 | The American College of Rheumatology 1991 revised criteria for the classification of globa | 1992 May | OBJECTIVE: To develop and validate revised criteria for global functional status in rheumatoid arthritis (RA). METHODS: Revised criteria were formulated and tested for criterion and discriminant validity in 325 patients with RA. RESULTS: The revised criteria developed are as follows: class I = able to perform usual activities of daily living (self-care, vocational, and avocational); class II = able to perform usual self-care and vocational activities, but limited in avocational activities; class III = able to perform usual self-care activities but limited in vocational and avocational activities; class IV = limited in ability to perform usual self-care, vocational, and avocational activities. Usual self-care activities include dressing, feeding, bathing, grooming, and toileting; vocational and avocational activities are both patient-desired and age-, and sex-specific. The distribution properties of this classification schema were superior to those of the original Steinbrocker criteria. Mean Health Assessment Questionnaire scores were significantly (P less than 0.0001) different between, and increased across, the 4 classes. CONCLUSION: Although there are limitations inherent in the use of global ordinal scales, the American College of Rheumatology revised criteria will be useful in describing the functional consequences of RA. A more detailed quantitative measure of physical disability should be used, however, for optimal monitoring of patients' clinical status in office practice and clinical research. | |
| 1464864 | Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumat | 1992 Oct | In a controlled, double blind, clinical trial we tested the effect of dietary omega-3 fatty acid supplementation with and without naproxen and placebo, respectively, in 67 patients with active rheumatoid arthritis. The patients were randomized into 3 groups that received the following treatment: Group 1, corn oil ("placebo omega-3 fatty acids"), 7 g/day for 16 weeks, and naproxen, 750 mg/day for 10 weeks followed by a stepwise reduction to 0 mg/day during the following 3 weeks; Group 2, omega-3 fatty acids, 3.8 g of eicosapentaenoic acid plus 2.0 g of docosahexaenoic acid, and naproxen, 750 mg/day for 16 weeks; and Group 3, omega-3 fatty acids as Group 2 and naproxen as Group 1. At the end of the trial, patients in Group 2 had improved with respect to duration of morning stiffness and global assessment by physician and patient. In Groups 1 and 3 there was a significant deterioration for most of the variables measured. However, for duration of morning stiffness the deterioration was significantly less pronounced in Group 3 compared with Group 1. These effects might be ascribed to the dietary omega-3 fatty acid supplementation. | |
| 8996473 | Undernutrition in rheumatoid arthritis patients with disability. | 1996 | Clinical evaluation of nutritional status (NS) was performed in 75 rheumatoid arthritis patients. They were distributed according to functional class, radiological stage and other prognostic factors (rheumatoid factor, extraarticular disease, disease duration). Evaluation of the different anthropometrical measurements in this group of long-standing RA patients (average disease duration: 10 years) revealed a significant impairment of lean body mass (LBM), especially among those with greater disability (Functional Class III and IV). Patients in more severe radiological stages (Radiological Stage III and IV) or patients with extraarticular disease also presented a significant loss of LBM compared with a matched cohort of the general population and patients with a more benign-course disease. There was less impairment of the fat mass, according to our clinical evaluation. Serological parameters of undernutrition (albumin and transferrin) did not show significant differences among the groups of patients. Clinical evaluation of NS in RA patients is a useful procedure for recognising patients at high risk of related complications by means of their poor nutritional status. | |
| 1352450 | T cell receptor gamma variable gene locus polymorphism in patients with rheumatoid arthrit | 1992 Jul | OBJECTIVE: We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor gamma (TCR gamma) genes. METHODS: We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCR gamma genes in a group of French control subjects and a group of French RA patients. RESULTS: No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III. CONCLUSION: These results exclude TCRV gamma I polymorphism as a disease susceptibility marker in RA. | |
| 8749295 | Results of CFV total wrist arthroplasty: review and early report. | 1995 Dec | Articulated total wrist arthroplasties have been used in the United States since 1974. In the 1980s the CFV wrist was developed in an attempt to reduce the incidence of imbalance, loosening, and bone resorption that has been seen in the early implants, and also to eliminate the use of bone cement. Since 1988, we have implanted 15 of these wrists. To date, nine patients are satisfied because of pain relief and motion; however, there have been 6 failures: 2 for infection, 3 because of a loose distal component, and 1 because of balance. Other problems that have been observed are flexor tenosynovitis, carpal tunnel syndrome, and a balancing problem. | |
| 7938652 | [Current views on pathogenesis and treatment of anemia in rheumatoid arthritis]. | 1994 | Anemia, especially anemia of chronic disease (ACD), is a frequent manifestation of rheumatoid arthritis. In the paper the mechanisms involved in the development of ACD and other causes of anemia in this disorder are reviewed. The new aspects in the treatment of anemia associated with rheumatoid arthritis, including erythropoietin, iron and chelation therapy are also discussed. | |
| 7633798 | Rheumatoid arthritis patients cannot accurately report signs of inflammatory activity. | 1995 Jun | If patients with rheumatoid arthritis (RA) could self-report symptoms in a manner which correlated with laboratory measures of inflammation this would be a valuable research or clinical tool. Developing such a tool means ensuring that the questions are understood and a variety of combinations of signs, symptoms and joints explored. Preliminary studies in two groups of 20 RA out-patients established an acceptable self-report questionnaire format by which patients could identify their joints. Fifty RA out-patients completed these self-report forms on four grades of each of four symptoms (pain, heat, stiffness, swelling) in each of 64 joints, as well as visual analogue scales (VAS) on overall pain and perceived disease activity. A clinical research assistant recorded the Thompson-Kirwan articular index (TKAI) and plasma viscosity (PV) was measured. The data were analysed in a variety of ways in an attempt to construct a self-report articular index (SRAI) which correlated with PV. The strongest models were then tested in 11 in-patients undergoing a flare of their disease. No adequate SRAI could be constructed which correlated with PV and in addition neither VAS score correlated with PV. There was a moderate correlation between the TKAI and a patient SRAI using the same joints, symptoms and weightings (r = 0.6, P < 0.01). Patients can clearly report different grades of multiple symptoms in multiple joints, but such reports cannot be shown to be a reliable indicator of inflammatory activity. | |
| 1564459 | Minimum 4-year follow-up of the PCA total knee arthroplasty in rheumatoid patients. | 1992 Mar | One hundred twenty-one consecutive nonrandomized primary total knee arthroplasties in 94 patients were performed between 1980 and 1984 using the Porous-Coated Anatomic prosthesis in patients with a diagnosis of severe rheumatoid arthritis. Of the 94 patients, 81 patients were able to be followed for more than 4 years, with the remaining 13 dying from unrelated causes prior to the 48-month follow-up. Of those arthroplasties with 48-month follow-up, 55 were uncemented and 26 were cemented. An 81% good to excellent result was seen for the cemented group and a 91% good to excellent result for the uncemented group. The postoperative arc of motion for the cemented group was 94 degrees, with the postoperative arc of motion in the uncemented group being 102 degrees. In evaluation of component interfaces, there were almost no lucencies seen among the femoral group, with no component failures in either group. Thirty-six percent of the uncemented group developed nonprogressive radiolucent lines along the tibial tray; 97% of these radiolucencies were less than 1 mm. Complications in the cemented group included a revision of one patellar and one tibial component for component loosening. In the uncemented group, complications included one case of deep sepsis following an intra-articular injection, loosening of two patellar components requiring revision, and loosening of two tibial components requiring revision. |