Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8595932 | Blood polymorphonuclear leukocyte migratory activities during rheumatoid arthritis. | 1995 Dec | Blood polymorphonuclear leukocyte (PMN) migratory activity was investigated in adult rheumatoid arthritis (RA) patients and in healthy control subjects using fresh whole blood in a novel membrane filter assay. The PMNs migrated under FMLP stimulation and under blank control conditions (spontaneous migration). Essential evaluation criteria were the percentage of PMNs that migrated from the entire blood sample into the filters (TMI) and the penetration depth of the migrating cell bulk into the filters (DC). PMNs from healthy subjects penetrate deeper under FMLP stimulation than under blank control conditions. Migration depends on age and sex: the TMI decreases, while the DC and the reactivity towards FMLP increase with age. FMLP triggers a stronger DC reaction in females than in males. Compared with healthy subjects, patients with RA develop an increased PMN reaction, whereas FMLP inhibits migration in comparison with the blank controls. There is no correlation between disease activity estimated by joint functions and PMN migratory activity, while there are strong correlations between disease activity and the classical RA laboratory parameters WBC, platelets, BSR, CRP, hemoglobin and rheumatoid factor. PMNs therefore probably do not play a major role in joint injury. Gold therapy inhibits DC reactivity. PMN migration in RA differs markedly from the reactions in juvenile rheumatoid arthritis, where high disease activity is associated with high PMN migratory activity, and the correlations between classical laboratory parameters and disease activity follow other patterns than in RA. | |
| 8434456 | Liver cirrhosis in rheumatoid arthritis patients treated with long-term methotrexate. | 1993 Feb | We undertook a retrospective review of all the liver biopsies done by us between 1985 and 1990 for the purpose of monitoring methotrexate (MTX)-induced hepatotoxicity in rheumatoid arthritis (RA) patients. A total of 29 biopsies were done in 25 patients. The mean total cumulative dose of MTX was 1585 +/- 348 (SD) mg. Average duration of MTX therapy was 31 +/- 9.8 mo (SD). Liver biopsy after accumulating 900 mg and 1200 mg MTX, respectively, in 2 obese diabetic patients showed evidence of cirrhosis. Obese diabetics may represent a subgroup of RA patients at risk for developing MTX-induced hepatotoxicity. | |
| 8970271 | The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knee | 1996 Apr | OBJECTIVE: To examine the efficacy of dexamethasone sodium phosphate (DEX) iontophoresis for the treatment of rheumatoid arthritis (RA) of the knee, and to obtain statistical information for a future randomized controlled trial (RCT). METHODS: Ten subjects with RA, ranging in age from 34-75, were randomly assigned to either the experimental or placebo group. Iontophoresis treatments were given to both groups on days 1, 3, and 5. Five subjects in the experimental group received a mixture of 1 ml of DEX (4 mg/ml) and 1 ml of injectable sterile water; those in the placebo group received 2 ml of saline solution. Pain on movement, at rest, and on pressure, active joint count, and active range of motion, were evaluated on days 1, 5, and 20. The patient's global assessment of treatment efficacy was also assessed on days 5 and 20. Mann-Whitney U tests and Friedman two-way analyses of variance were performed for statistical analyses. RESULTS: Pain at rest was found to be statistically different between the two groups (P = 0.0317). Statistical significance was also found over time for pain on movement within the experimental group (P = 0.0224). CONCLUSION: The results suggest that DEX iontophoresis is more effective than placebo in relieving pain at rest and on movement in the RA knee. Based on the study data, a total of 40 subjects will be required for an RCT of a similar nature. | |
| 7604173 | [Laboratory and instrumental clinical study of 150 patients with psoriatic arthritis]. | 1995 May | The study included a 5-year-follow-up. We noticed that our data did not agree with the data in literature as regards the distribution percentage of the various articular subsets. It was pointed out that the distribution percentage of some particular clinical subsets of the disease (for example the symmetrical polyarticular subset and the spondylitic and/or sacro-iliac subset) were linked to sex. The study of the bio-humoral parameters showed that the most significant data was the particular clinical and radiological severity of PA in the patients with high IgA levels. Radiological findings showed the involvement of the sterno-clavicular and manubriosternal joints by osteoproduction and/or erosive manifestations, which was associated with a particular clinical severity of the disease. Eventually, our study revealed a significant relationship between psycho-physical stress and articular and/or cutaneous manifestations of the disease. This data seems to confirm the recent neuro-immunological studies hypothesizing a likely role of stress and subsequent depression in the ethiopathogenesis of rheumatic diseases caused by an immune imbalance. | |
| 8156309 | Overall long-term impact of total hip and knee joint replacement surgery on patients with | 1994 Apr | All patients with OA or RA entering an orthopaedic waiting list for total hip or knee replacement surgery over a period of 2.5 yr were prospectively assessed for overall pain (Visual Analogue Scale) and disability (Health Assessment Questionnaire) prior to and following their operation at annual intervals for up to 5 yr. A total of 293 patients had 335 operations (OA, hip 164; OA, knee 76; RA, hip 41; RA, knee 54). A few patients (14) showed a deterioration in pain and function 1 yr after surgery, but the remainder showed improvements which took 1 yr or more to reach maximum and were maintained for at least 3 yr. Although greater for OA hip patients, improvements occurred and were maintained in all groups, in spite of the polyarticular nature of RA. | |
| 8046330 | Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice. | 1994 Aug 1 | B10.Q (H-2q) mice congenic for the truncated T cell receptor (TCR) V beta a and V beta c haplotypes were derived to examine the influence of TCR V beta genomic deletions in murine collagen-induced arthritis (CIA). Previous studies using gene complementation and segregation analyses suggested that in SWR (H-2q) mice, possession of the V beta a gene deletion results in CIA resistance. However, other studies have suggested alternative hypotheses. Thus, analysis of TCR V beta congenic mice allows for direct examination of V beta genotypes in CIA control. After immunization with bovine type II collagen, B10.Q-V beta a mice showed no difference in arthritis susceptibility, onset, or severity when compared with prototype B10.Q mice. In contrast, B10.Q-V beta c mice, which lack the V beta 6, 15, 17, and 19 families in addition to the V beta a deletion, were highly resistant to CIA. In vivo depletion of V beta 6+ T cells in B10.Q-V beta a mice significantly delayed arthritis onset suggesting that, among those V beta genes present in V beta a but absent in V beta c, V beta 6+ T cells contribute to arthritogenesis. Our findings show that, in B10.Q-V beta congenic mice, while the V beta a genotype does not prevent CIA, the highly truncated V beta c genotype renders B10.Q mice resistant to CIA. Thus, deletions within the V beta TCR genome can indeed influence CIA and suggests that the TCR repertoire displays only marginal flexibility in response to arthritogenic stimuli. | |
| 8438179 | Subluxation of the upper thoracic spine in rheumatoid arthritis. | 1993 | Only single cases with rheumatoid arthritis of the thoracic spine with vertebral subluxation have been reported to date. In a review of 100 patients with severe rheumatoid arthritis who had undergone occipitocervical fusion, arthritis of the upper thoracic spine with subluxation was discovered on conventional radiographs in four patients. Two additional patients were found elsewhere. Magnetic resonance imaging (MRI) was performed in three of the patients, confirming the diagnosis of subluxation of the upper thoracic vertebrae. In addition, MRI revealed encroachment on the anterior subarachnoid space and compression of the spinal cord. | |
| 8809445 | IgA isotype rheumatoid factor in rheumatoid arthritis: clinical implications. | 1996 May | OBJECTIVES: To study the clinical, biological and radiological characteristics of RA with a predominant increase of IgA isotype rheumatoid factor (IgA-RF) over IgM-RF. METHODS: The presence of IgA-RF was determined by a sandwich-type ELISA with an antibody against the human IgA used to capture the immunoglobulin. Associated RF activity was revealed with a peroxidase-conjugated human IgG Fc fragment. Forty-nine RA patients were studied, of whom 19 had an increase in IgA-RF (38%). The control group comprised 30 RA patients without IgA-RF. RESULTS: None of the patients had isolated IgA-RF. In the selected 19 RA patients, the OD of IgA-RF (0.971 +/- 0.62 U) was higher than the IgM-RF (mean OD: 0.675 +/- 0.522 U). A statistically significant correlation was found between IgA-RF and IgM-RF (r = 0.64, p < 0.0001). No correlation was noted between the IgA concentration and the IgA-RF titer. The two groups were comparable for age, disease duration, sex ratio and previous DMARD use. We observed that patients with RA associated with increased IgA-RF more often had the sicca syndrome, but no other extra-articular features. RA patients with IgA RF also had more erosive disease: the mean Larsen score at the hand and wrist was 76 (SD = 68) versus 54 (SD = 60) in the controls, p < 0.02. Replacement surgery for the hip or knee was necessary in 47% of the RA patients with IgA-RF, versus 13% in the controls, p < 0.01. No association of IgA-RF with disease activity was noted. CONCLUSION: Our study showed that RA patients with a predominant increase of IgA-RF had a more erosive disease and a high frequency of associated sicca syndrome. | |
| 7561491 | Inner ear involvement in rheumatoid arthritis: a prospective clinical study. | 1995 Aug | Sensorineural hearing loss in rheumatoid arthritis (RA) has been reported to be the result of the extra-articular manifestation of the disease (rheumatoid nodular vasculitis) or due to drug ototoxicity. In an attempt to investigate the presence of sensorineural hearing loss and the possible causes for it we investigated prospectively 45 RA patients (42 female; three male) with a mean age of 52.5 +/- 10.7 years and a mean disease duration of 8.5 +/- 7.3 years. All patients underwent a complete physical examination and audiological evaluation which included pure tone audiometry and impedance audiometry (tympanogram, static compliance, acoustic reflex, reflex decay, acoustic reflex latency test. We found a sensorineural hearing loss > 20 dB HL in 44.4 per cent (40/90) ears. In all cases the site of hearing loss was the cochlea and in most of them it was bilateral and symmetric (16 patients out of 45 had bilateral sensorineural hearing loss i.e. 35.5 per cent. There was no correlation between sensorineural hearing loss and age, sex, disease duration, articular and extra-articular manifestations and the presence of autoantibodies in our patients. In addition, no correlation was found between sensorineural hearing loss and drug therapy for one at least of the following drugs: NSAIDs, D-penicillamine, plaquenil and methotrexate. We noticed a prologation of acoustic reflex latency in five patients (10 per cent) which was found to be correlated with the temporomandibular joint involvement and the presence of rheumatoid factor (RF). We conclude that inner ear involvement in RA is expressed by: (1) mild symmetric, bilateral sensorineural hearing loss of cochlear type in 35.5 per cent of patients; (2) normal acoustic reflex thresholds; (3) nondecay; and (4) prologation of acoustic reflex latency which appeared in a small number of patients (10 per cent). | |
| 10150834 | Ocular manifestations of immunologic and rheumatologic inflammatory disorders. | 1994 Dec | Exciting new discoveries into the pathophysiological mechanisms of immunologic and inflammatory ocular disease continue. The genetic locus for susceptibility to Behçet's disease and Sjögrens syndrome has been further characterized. Important guidelines for serial slit-lamp examinations for the early detection of iridocyclitis in juvenile rheumatoid arthritis is suggested. In ocular allergy, further investigation of the interaction between mast cell and eosinophil sheds more light on the pathophysiological mechanism of vernal keratoconjunctivitis and vernal corneal ulcers. Unusual manifestations of Behçet's disease, sarcoidosis, scleritis, and Wegener's granulomatosis are reported. A possible pathophysiological mechanism for lacrimal gland destruction in Sjögrens syndrome is presented. | |
| 8339473 | Surgery of the rheumatoid cervical spine. Correlation of the pathology and prognosis. | 1993 Aug | Twenty-eight rheumatoid arthritis patients with symptomatic subluxation of the cervical spine had 34 operative procedures in the period from 1983 to 1989. Two distinct groups are noted with regard to management and prognosis. The treatment of isolated atlantoaxial instability has been straightforward and the morbidity low. Subaxial instability and combined atlantoaxial and subaxial instability were more difficult to manage: The incidence of preoperative neurologic deficit was higher and the operative technique more demanding. There have been two late deaths of quadriparesis. Half of the other patients were ambulant and independent. The halo jacket has been used to reduce subaxial subluxation and neurologic deficit before surgery. Both anterior and posterior approaches have been successfully employed. | |
| 8515024 | Motion after metacarpophalangeal joint reconstruction in rheumatoid disease. | 1993 May | The outcome of reconstruction of the rheumatoid metacarpophalangeal joint may deteriorate with time, especially with respect to active motion. This study assesses active finger motion after crossed intrinsic transfer and Swanson implant arthroplasty at increasing durations of follow-up to determine the effect of time. In a total of 58 patients, 21 hands had the crossed intrinsic transfer operation and 49 had the arthroplasty. Follow-up time averaged 6 years for the crossed intrinsic transfers and 21 months for the arthroplasties. Measurement of metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joint active motion at each follow-up interval were analyzed by the univariate repeated measures analysis of variance method. After crossed intrinsic transfer the overall average active range of motion decreased significantly (18 degrees) at the metacarpophalangeal joint. Proximal interphalangeal and distal interphalangeal average range of motion significantly increased during the first 5 years as a result of increases in flexion. After implant arthroplasty, the overall average metacarpophalangeal range of motion analysis at the different follow-up intervals showed that the metacarpophalangeal average range of motion significantly increased during the first 2 years and then gradually declined through the duration of follow-up. Active proximal interphalangeal flexion was also significantly increased during the first 2 postoperative years. The effects of metacarpophalangeal joint reconstruction on active finger joint motion are related to the duration of postoperative follow-up; this concept should be considered when one is planning metacarpophalangeal joint reconstruction in rheumatoid patients. | |
| 8804206 | [Development of standards by the Norwegian Society of Rheumatology. Control of disease mod | 1996 Aug 20 | Rheumatoid arthritis is a serious disease associated with increased morbidity and mortality, and requires adequate routines for therapy and follow-up examination. This article presents the work of the Norwegian Society for Rheumatology to improve the quality of the therapeutic assessment of patients with rheumatoid arthritis in Norway. The process of reaching an agreement involved a large number of rheumatologists. The final meeting included a variety of activities, plenary lectures, workshops, group discussions and opinion polls. A literature search through Medline was provided continuously. Agreement was achieved on a programme for monitoring therapy with disease-modifying antirheumatic drugs, which was to comprise visits to the physician and laboratory tests. This programme was later voted on and affirmed by the Annual Meeting of the Norwegian Society for Rheumatology. Proposals were issued regarding endpoint measures to assess progression of the disease. These proposals can be expected to improve the quality of treatment and management of patients with rheumatoid arthritis, both in primary health care and in the specialized rheumatological health service. | |
| 8782125 | Measurement of serum hyaluronic acid in patients with rheumatoid arthritis: correlation wi | 1996 Jun | OBJECTIVE: To examine serum concentrations of hyaluronic acid (HA) in patients with rheumatoid arthritis (RA) and to investigate the relationship between clinical measures of disease activity and serum HA concentrations in these patients. METHODS: Sixty-five patients with established RA were enrolled and RA disease activity was measured by clinical variables. Serum samples obtained at the time of the clinical evaluation were assayed for serum HA, erythrocyte sedimentation rate (ESR), and C reactive protein (CRP), and correlations between these laboratory variables and clinical disease activity were sought. RESULTS: Concentrations of serum HA were higher in patients with RA than in healthy controls. There was statistically significant correlation between patient age and serum HA and between serum HA and disease activity measured by physician assessment and number of swollen joints. Correction for age strengthened the correlation between serum HA and measures of disease activity. ESR did not correlate with any measure of clinical disease activity. CRP concentrations correlated with physician assessment of disease activity, and number of swollen joints and tender joints, but the correlation was not as strong as the correlation between serum HA and disease activity variables. CONCLUSION: Measurement of serum HA may be a useful measure of disease activity in patients with RA. Measurement of serum HA appears to be a better correlate of clinical disease activity in patients with RA than ESR or CRP. | |
| 7551668 | Atlanto-occipital subluxation in rheumatoid arthritis demonstrated by magnetic resonance i | 1995 Aug | Atlanto-occipital subluxation is a rare but recognized form of subluxation that occurs in rheumatoid arthritis (RA) at the cranio-cervical junction. Magnetic resonance imaging (MRI) clearly demonstrates the bony and soft tissue changes of RA in the cervical spine. We report a single case of atlanto-occipital subluxation in RA demonstrated by MRI. | |
| 7966056 | Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in v | 1994 Jul | OBJECTIVE: To independently confirm previous probe drug findings that patients with rheumatoid arthritis (RA) have defective oxidation of cysteine derivatives. METHODS: Measurement of cysteine dioxygenase substrate (cysteine) and product (sulfate) under controlled conditions, with elemental assessment by proton induced x-ray emission (PIXE). RESULTS: Plasma inorganic sulfate was significantly depressed in patients with rheumatoid arthritis (RA) compared to both controls and non-RA disease, 85 +/- 36 nm/ml vs 267 +/- 146 and 604 +/- 412 (mean +/- SD. RA patients vs non-RA disease p < 0.001). Fasting cysteine levels were significantly raised compared to controls (59 +/- 20 nm/ml vs 17 +/- 81 nm/ml p < 0.001). Synovial fluid (SF) sulfate was also significantly reduced in patients with RA compared to non-RA controls (202 +/- 117 nm vs 1041 +/- 700 p < 0.001). PIXE data confirmed the low sulfate levels in serum and SF while showing no reduction in the levels of other elements analyzed. CONCLUSIONS: These cysteine/sulfate findings confirm the validity of the previous probe drug abnormalities and the importance of defective cysteine dioxygenase activity in RA. | |
| 8519939 | [Acute ischemia of the lower limb in a patient with temporal arteritis and rheumatoid arth | 1995 Oct | We report a case of Temporal Arteritis, carrier of IgG anticardiolipin antibodies, who presented seronegative polyarthritis with AR criteria after 7 months. Three months later he developed acute ischemia in the right leg, which induced to amputate it. The biopsy showed thrombosis of the femoral arteria, and a dense lymphoplasmocytic infiltrate in its wall. We underline this association (TA-RA) with anticardiolipin antibodies, the exceptional affectation of the femoral arteries in this disease and the probable participation of anticardiolipin antibodies in the genesis of the arterial thrombosis. | |
| 7871907 | [Incidence of acral nodulosis with long-term methotrexate therapy in patients with inflamm | 1994 Nov | The significance of acral nodulosis under methotrexate therapy is still controversial. Among patients with rheumatoid arthritis and methotrexate therapy this manifestation could be observed in 8/163 (5%). All cases were seropositive and already treated with other LAAD. Patients with other inflammatory rheumatic diseases under methotrexate therapy (n = 83) did not develop this nodulosis. The acral nodulosis is interpreted as a typical side-effect of methotrexate only in patients with rheumatoid arthritis. Histopathologically, these nodules do not differ from the typical rheumatoid nodule. | |
| 9213882 | [Incorrect diagnosis of peripheral arthritis in ankylosing spondylitis]. | 1996 | We present a case of female patient who's been treated 28 years, under the diagnosis of rheumatoid arthritis because of the symmetric polyarthritis. After 28 years radiography of sacro-iliac joints and thoracolumbar vertebra was taken and showed changes typical for ankylosing spondylitis with asymmetrical affection of peripheral joints and with irreversible changes only in knees joints. Rheumatoid factor in serum was always negative, and the patient has also an iridocyclitis. We conclude that the diagnosis is surely ankylosing spondilitis. | |
| 7699620 | High levels of anti-type II collagen IgG in west African patients with rheumatoid arthriti | 1994 Dec | OBJECTIVE: To compare levels of antitype II collagen IgG in West African and British patients with rheumatoid arthritis (RA). METHODS: IgG levels to native and denatured type II collagen were measured by ELISA: RESULTS: Serum levels of antinative type II collagen IgG were raised in 17 of 58 (29%) West African patients with RA. In contrast, 14 of 89 (16%) British RA patients had raised levels of antinative type II collagen IgG. Levels of antinative type II collagen IgG were also higher in West African patients with RA than in the British patients. CONCLUSION: Our results suggest that type II collagen autoimmunity plays a more prominent role in RA in West Africa than in Britain. |