Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8403586 | A double-blind study to determine the duration of action of flurbiprofen in a sustained re | 1993 Jul | This double-blind, placebo-controlled, parallel-group study proves that the duration of activity of a sustained-release preparation of flurbiprofen 200 mg covers a full 24 hour period. In a group of 24 patients with clinically active rheumatoid arthritis a statistically significant increase of pain was noted 37 hours after the last active dose. The increase in disease symptoms was inversely related to the plasma flurbiprofen levels and was rapidly reversed with one active dose of sustained release flurbiprofen. | |
| 8294822 | Wrist arthrodesis using an embedded iliac crest bone graft. | 1993 Oct | 34 patients treated by the iliac crest bone graft technique for wrist arthrodesis were reviewed. The average age was 45.6 years and the mean follow-up was 45 months. The procedure is performed through a straight ulnar approach and the head of the ulna is removed. A longitudinal trench is created in both distal radius and carpus preserving the anterior, posterior and lateral cortices. A curved trapezoidal monocortical iliac crest bone graft is embedded inside the trench. The position of the arthrodesis automatically follows the curvature of the graft. No fixation device is used. A short-arm cast is applied for 2 to 3 months. All arthrodeses except two fused within 3 months. Pain was completely relieved in 85% of the cases. Pronation and supination returned to normal 5 months post-operatively. Grip strength was increased in 80% of the cases. The carpometacarpal joints remained pain-free even when not fused. Complications were rare: two lesions of the dorsal branch of the ulnar nerve; two cases of delayed union due to errors in technique, and displacement of the graft in one case. Although it is technically demanding, the embedded iliac crest graft wrist arthrodesis improves pronation and supination as a result of resection of the distal radio-ulnar joint, preserves or improves grip strength, and relieves pain. | |
| 8578543 | Effective anticoagulation by argatroban during immunoadsorption therapy for malignant rheu | 1995 Oct 1 | Polymorphonuclear leukocyte elastase (PMNE) is a glycoprotein with a molecular weight of about 30000 and exists in 3 isozymes (1). It has a biological role in host defense mechanisms, but it sometimes induces abnormal blood coagulation and injury of the vascular intima (1,2). We were not able to obtain a satisfactory anticoagulant effect when using heparin during immunoadsorption therapy in a patient with malignant rheumatoid arthritis and high PMNE level, but found that argatroban, a selective antithrombin agent, produced satisfactory anticoagulation. This finding is interesting as far as the various pathologic roles of PMNE are attracting increasing clinical attention (1,2,3). | |
| 1364169 | Does C-reactive protein modulate T-lymphocyte function in methotrexate-treated rheumatoid | 1992 Nov | Thirty-four patients with rheumatoid arthritis were treated with oral methotrexate for 6 months. Methotrexate was given as a single weekly dose of 7.5-10 mg. A correlation between serum concentration of CRP and proportion of CD8+ lymphocytes in peripheral blood was found in this group of patients. This correlation can be described by a linear regression equation. According to the results obtained, CRP suppresses lymphocyte function in patients with RA. This is the consequence of the stimulating effect on suppressor mechanisms. | |
| 8444628 | Social support interventions for rheumatoid arthritis patients: the cart before the horse? | 1993 Spring | Enthusiasm about the potential of social support to promote successful adaptation to chronic illness has already led to support interventions for arthritis patients designed to increase coping ability, reduce the need for professional mental health services, and limit periods of disability. But have we put the cart before the horse? Do these interventions achieve these goals? Existing interventions are reviewed, and a number of research issues are addressed from within an ecological framework, including the content of support interventions, the source of support, the type of support provided, support as an intervention variable versus outcome, and the need to target interventions not only to patients but to their family members and health professionals. It is suggested that future interventions be more theoretically grounded. | |
| 9036723 | [Hormonal status of the woman and its effect on symptoms and progression of chronic polyar | 1996 | In a retrospective study 434 female patients suffering from rheumatoid arthritis (mean age at the onset of disease 45.7 +/- 13.3 years) were asked about information concerning number of deliveries, abortions, hormonal contraception or treatment respectively, and any changes of complaints during pregnancy, after deliveries or hormonal treatment. The effect of oral contraceptives on the progression of the disease was of particular interest. The present results show that the progression of RA is not influenced dramatically by the hormonal situation or hormonal treatment respectively. The worldwide opinion of female sex hormones regarding their influence on symptoms and progression of RA and the risk of developing RA are controversial. Positive and negative studies on the influence of hormonal situation or treatment respectively are depending very much on the individual study conditions. In order to find out more on the effects of hormones on RA, a prospective approach and much more data would be required. This is the reason why no study so far has shown unanimously acceptable results. | |
| 7529838 | Validity of acute phase proteins as markers of disease activity. | 1994 Oct | It has long been recognized that various rheumatic diseases, including rheumatoid arthritis (RA), are associated with a rise in concentration of acute phase proteins, particularly C-reactive protein (CRP) and serum amyloid A. The levels of these 2 proteins increase very rapidly over hours after the acute phase response is initiated. However, at present, only the measurement of CRP is widely available. Studies have shown that CRP is a better indicator of disease activity than erythrocyte sedimentation rate. CRP also appears to correlate with, and be predictive of, radiographic progression in RA. Although CRP has been shown to reflect disease activity and radiographic progression, there appears to be discordance between CRP response and drug therapy. With nonsteroidal anti-inflammatory drugs, there is essentially no change in the CRP response. However, CRP levels have been shown to decrease in patients who respond to disease modifying antirheumatic drugs. It is possible, therefore, that CRP could be used as an early predictor of response to therapy. | |
| 1455045 | Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping | 1992 Nov | Recent methodologic advances now allow the precise identification of HLA genes in individuals. Population studies using these methods have pinpointed the HLA alleles strongly associated with rheumatoid arthritis (RA). This article summarizes the current status of these RA-associated HLA genes in disease susceptibility and uses that information to derive estimates of risk ratios for prediction of disease in an individual. | |
| 8664936 | Sequential occupational dexterity assessment (SODA): a new test to measure hand disability | 1996 Jan | Measuring hand-related disability poses a problem due to a lack of validated tests. This report introduces the sequential occupational dexterity assessment (SODA), a test that measures bimanual dexterity in daily life. The design of the SODA is described. Validity and reliability of the SODA are demonstrated in a sample of patients with rheumatoid arthritis (RA), in whom impairment of the hands may cause serious disability in daily life. Good reliability was found, as measured by internal consistency, test-retest correlation, and interrater stability. Validity was established by relating the SODA to a number of other variables. Current disease activity was only weakly related to the SODA score. Impairment of the hands is more strongly related to dexterity than to current disease activity. However, dexterity could vary considerably in patients with similar degrees of impairment. Pain during the SODA proved to be more important for dexterity than general level of pain. Considerable variation was found in self-reported and observed dexterity. It was concluded that the SODA may guide the therapist in making decisions about hand therapy. The use of the SODA allows standardized evaluation of the effects of hand surgery on bimanual dexterity. | |
| 7918726 | Social network characteristics in fibromyalgia or rheumatoid arthritis. | 1994 Mar | PURPOSE: To describe trends in the personal social network characteristics of the fibromyalgia patients compared with the network of patients with another chronic disorder such as rheumatoid arthritis (RA). METHODS: A structured interview was applied to 10 fibromyalgia patients and 10 matched RA patients. RESULTS: The networks of the 10 fibromyalgia and 10 RA patients were comparable in most respects, namely: the small number of intimate friends, the reliance for support on the spouse and the physician, and the relative lack of new social contacts. Furthermore, the fibromyalgia networks were closed networks within a small geographic area. These networks lacked initiative to establish and maintain relations, and can hardly fulfill the patients' psychosocial needs. CONCLUSION: Based on small numbers, the study provides some evidence that social networks of patients with fibromyalgia are more restricted than those of RA patients. Further studies should include larger numbers of patients to clarify cause and effect relationships and to suggest new directions in the treatment of chronic disorders such as fibromyalgia. | |
| 1586243 | Influence of the severity of rheumatoid arthritis on sex differences in health assessment | 1992 Apr | In a study of 284 consecutive patients with rheumatoid arthritis attending hospital clinics a previous observation that female patients score higher on the Stanford Health Assessment Questionnaire (HAQ) than men was confirmed. A clinical disease severity score and the spread/severity index also showed that women had more severe disease. Although scores in some categories of the HAQ were higher in women, they were not disproportionately so, providing no evidence that domestic categories of the HAQ are biased against women. A multiple regression analysis showed that the spread/severity index score was the best predictor of HAQ scores, with sex making no significant contribution. The severity of the disease adequately explained the higher HAQ scores in female patients with rheumatoid arthritis. | |
| 1504435 | Follicular bronchiolitis associated with rheumatoid arthritis. | 1992 May | Follicular bronchiolitis is a rare disorder, though it has been recognized as a pulmonary involvement of rheumatoid arthritis in recent years. A 57-year-old woman with rheumatoid arthritis was admitted to the hospital with persistent productive cough and breathlessness on exertion. An open lung biopsy was performed to establish a definite pathologic diagnosis of her disease, and she was diagnosed as having follicular bronchiolitis on the basis of the histopathological findings. It is essential to differentiate this disease from other bronchiolar or lymphoproliferative disorders of the lung. | |
| 8975346 | [Results of early rehabilitation using various knee prosthesis models]. | 1996 Aug | The present contribution deals with the early rehabilitation outcomes achieved using total knee arthroplasties with major differences in design. Hinged and unhinged total knee replacements are compared for a total of 100 patients included in the prospective study (48 hinged prostheses, and 52 unhinged ones). Evaluation of the functional and subjective parameters included shows that major improvements in total scores had been achieved in both groups already after 5 weeks, even more pronounced after 10 weeks. With a number of differences found for the various criteria assessed, it in particular is the fact of early stability of the joint in using the hinged prostheses that entails speedy progress and a good rehabilitation outcome. Due consideration of the different early outcomes for the various parameters, hence, is imperative in pre-operative decision-making. | |
| 8326356 | Validity of rheumatoid arthritis diagnoses listed in the Saskatchewan Hospital Separations | 1993 Jul | A Saskatchewan hospital separations database was compared to abstracted hospital records to determine the reliability of the database (i.e. accuracy with which the computer data reflect the charts from which they were coded) and the validity of classifying rheumatoid arthritis status with the database (i.e. the extent to which rheumatoid arthritis mentioned in the database reflected the condition of the patient). A sample of hospitalized subjects fell into three categories: 144 who never had a database diagnosis of any arthritis, 146 who had a database diagnosis of osteoarthritis, and 142 who had a database diagnosis of rheumatoid arthritis. These 432 people experienced 1717 hospitalizations eligible to match a hospital database listing by date, and 1618 matched. Of the remaining 99, 35 were relatively recent and probably had not yet been entered into the database, 39 were possibly entered incorrectly, and 25 could not be matched in any way. Of 150 hospitalizations with a database diagnosis of rheumatoid arthritis, this diagnosis was in the hospital record for 125. Chart documentation of rheumatoid arthritis status was greatest for subjects who, according to the database, were hospitalized by a rheumatologist: of 73 subjects in this category, abstractions showed 69.9% met > or = 5 American Rheumatism Association criteria, 15.1% met < 5 criteria but had a rheumatologist's diagnosis of rheumatoid arthritis, 1.3% met < 5 criteria and had a rheumatoid arthritis diagnosis by a non-rheumatologist, and 13.7% had no mention of rheumatoid arthritis or its symptoms in any medical record abstracted. In summary, reliability of the database was excellent, but validity depended on the source of diagnosis. | |
| 8401999 | Major histocompatibility complex variants and articular disease severity in rheumatoid art | 1993 Oct | In the light of associations previously described between DR4, DQw7, the C4B null allele and Felty's syndrome, and between Dw14, the C4A null allele and rheumatoid vasculitis, we have looked for associations between these and other DRB1, DQB, DQA and C4 encoded variants, and articular disease severity assessed radiologically in 119 subjects with RA but without major extra-articular features. The association of DR4 with more severe disease and DR1 and DR2 with mild disease was confirmed but no associations were found between the presence of DQw7, Dw14, C4A or C4B null alleles and articular disease severity. This suggests that the associations noted previously between these markers and extra-articular disease features of Felty's syndrome or rheumatoid vasculitis are unlikely to reflect an overall effect on disease severity but more likely to represent associations with these particular extra-articular disease subsets. | |
| 10162991 | By the numbers. Care for arthritis and other chronic conditions. | 1996 Nov | This issue's "By the Numbers" highlights recent findings on care for patients with rheumatoid arthritis in HMO and fee-for-service (FFS) settings. It also looks at the prevalence of arthritis and other chronic conditions in these plans. | |
| 8519073 | Rheumatoid arthritis: other rheumatoid lung problems. | 1993 Feb | In summary, it appears that factors such as smoking and the presence of secondary Sjögren's syndrome might be important in predisposing the rheumatoid patient to the development of lung disease. Genetic factors may moderate or magnify these risks. At a cellular level, specific macrophage colonies within the lung may interact with a subgroup of CD4 T lymphocytes to produce unopposed B-cell activation, leading to local IgM production and the formation of immune complexes. This can damage lung both directly by cytolysis and indirectly by granulocyte recruitment through the release of neutrophil chemotaxins. Early in the evolution of these processes, steroids appear able to reduce lymphocyte numbers and prevent lung damage occurring, presumably by immunological mechanisms, while later they may reduce granulocyte numbers and activity, halting further progression of lung disease in some patients, perhaps by a direct anti-inflammatory effect. Confirmation of these mechanisms and the development of more specific therapeutic tools is probably dependent on studies which examine lung tissue directly by biopsy and may be aided by the application of more sensitive imaging techniques. | |
| 8747080 | Biological markers in inflammatory rheumatic diseases. | 1995 Dec | Biological markers of inflammation are useful for the diagnosis and the monitoring of inflammatory rheumatisms and connective tissue diseases. These markers are not specific, and often poorly correlate with the long term evolution of the disease. C-reactive protein (CRP) is a sensitive marker, and is used to monitor inflammatory and infectious diseases. In rheumatoid arthritis (RA), CRP correlates with disease activity and response to therapy, and CRP levels are influenced by disease-modifying drugs and corticosteroids. Serum amyloid A (SAA) is another acute phase protein (APP) which appears in RA as a more sensitive marker than CRP. Several antinuclear antibodies serve as markers of systemic disorders; they are not implicated in the disease by themselves, but their production could be related to the genetic background underlying the pathogenesis of the disease. In systemic lupus erythematosus (SLE), the titer of anti-ds DNA antibodies often correlates with disease activity. DNA is poorly immunogenic and the production of anti-ds DNA antibodies could be linked to the association of DNA with more immunogenic protein antigens. Cellular DNA is associated with proteins in nucleosomes and it now appears more appropriate to consider the anti-DNA antibody production as a response to a DNA-protein complex. Antibodies can be directed to histones and DNA-protein complexes such as transcription or replication complexes. Antibodies to ribonuclear proteins are associated with different disease subsets and help to define the prognosis in SLE and connective tissue diseases. The identification of antibodies directed against proteins and RNA components is still a field of research. | |
| 1374251 | Amelioration of antigen-induced arthritis in rabbits treated with monoclonal antibodies to | 1992 May | OBJECTIVE: To examine the effects of treatment of antigen-induced arthritis in rabbits with a monoclonal antibody against CD18, the common beta chain of the leukocyte adhesion molecules. Intraarticular injection of antigen into primed rabbits elicits an acute inflammatory response followed by chronic arthritis in this model. METHODS: Anti-CD18 was given at the time of intraarticular antigen administration, and effects on the acute and chronic arthritis were investigated. Twenty-four rabbits were examined (11 controls, 3 receiving normal mouse IgG, and 10 receiving anti-CD18). RESULTS: Flow cytometry of blood leukocytes at anti-CD18 administration showed saturating amounts of mouse Ig coating all the circulating cells. Treatment effects on the acute arthritis (measured by quantitating the synovial cell exudate 24 hours after arthritis induction) were a profound reduction in the number of inflammatory cells and a striking decrease in the proportion of polymorphonuclear leukocytes recovered from the synovial cavity, indicating a decrease in acute inflammation. Treatment effects on the chronic synovitis (2 and 4 weeks later) compared with controls showed a significant decrease in synovial fluid cell counts at 2 weeks (1.7 versus 21.0 x 10(6)/joint, P less than 0.03) and at 4 weeks (7.4 versus 22.6 x 10(6)/joint, P less than 0.05). Histologic evaluation of the synovium (0-3+ scale, scored "blindly") of anti-CD18-treated rabbits and controls showed marked decreases in subsynovial cell infiltration and lymphoid follicle formation both at 2 weeks (1.0 versus 2.25, P less than 0.005; and 0 versus 1.75, P less than 0.001) and at 4 weeks (1.48 versus 2.17, P less than 0.01; and 0.75 versus 2.08, P less than 0.02). Quantitation of cartilage-bound immune complexes, and of synovial synthesis of Ig and specific antibody showed no differences between groups. CONCLUSION: These findings indicate that treatment with monoclonal antibody to CD18 not only modifies the initial acute arthritis, but also results in significant amelioration of the subsequent chronic inflammation in this animal model of rheumatoid arthritis. | |
| 8036601 | [A comparative evaluation of the treatment results with cyclosporin A, methotrexate and az | 1993 | In a randomized trial 43 patients with RA systemic manifestations received for 6 months immunodepressants: azathioprine, methotrexate and cyclosporin A (12.15 and 16 patients, respectively). Ten more patients resistant to immunodepressants were given cyclosporin A. The drugs were found to produce a positive effect on clinical symptoms and laboratory indices of the disease. Cyclosporin A is thought a basic immunodepressant without serious hematological or infectious complications. Occasionally it can be useful in failure of other immunodepressants administered to RA patients. |