prior knowledge of Biomarkers
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miRNA_namehsa-mir-26b
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PMID26088648
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DescriptionMiR-26b regulates ÉÇ-catenin and CyclinD1 levels by inhibiting GSK-3ÉÇ expression, which in-turn alters the Wnt/GSK-3ÉÇ/ÉÇ-catenin pathway to lower RAFLS proliferation and elevate cell apoptosis and the secretion of TNF-Ï«,IL-1ÉÇ and IL-6 cytokines. Therefore, our results show that miR-26B plays a central role in inhibiting the inflammation associated with rheumatoid arthritis.
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CausalityYES
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