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prior knowledge of Biomarkers

  • circRNA_name
    hsa_circ_0060144
  • Synonyms
    hsa_circRNA_104871
  • Chromosome
    9
  • Position
    114840817-114842445
  • Strand
    -
  • Genome_Version
    hg19
  • Gene_symbol
    SUSD1
  • Circ_Sequence
    TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG
  • Circ_Type
    exonic
  • Disease_name
    rheumatoid arthritis
  • Methods
    microarray; qRT-PCR
  • Sample
    PBMCs from 35 patients with RA and 30 healthy controls
  • Location
    N/A
  • Expression_pattern
    up-regulated
  • miRNA
    N/A
  • miRNA_Target
    N/A
  • RBP
    N/A
  • RBP_Target
    N/A
  • Functional_description
    We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.
  • PubMed_ID
    28618429
  • Pub_Year
    2017
  • Journal
    Cell Physiol Biochem
  • Title
    Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients
  • Notes
    N/A
  • UpGene
    NA
  • DownGene
    NA
  • Regulation_Description
    NA
  • details
    circRNA_name
  • NA
  • download source file
    Circ2Disease.xlsx