Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2931846 | [Comparative analysis of the effectiveness and tolerance of chrysanol and myochrysine in p | 1985 | Fifty patients with a significant rheumatoid arthritis (RA) were treated with gold salts for 6 months to 4 years. Patients with highly active conditions (stages II-III) and with erosive arthritis (stages IIb-IV) prevailed. Extraarticular manifestations were recognized in 76% of the patients. The efficacy of chrisanol given in a dose of 1.5 ml of a 5% solution was compared to that of myocrisin in a dose of 50 mg, i. e. 25 mg metallic gold once a week. The efficacy of the drugs was evaluated from their effects on the disease activity (clinical manifestations of the articular syndrome, ESR, morphological signs of rheumatoid synovitis) and progression (the rate of the development of erosive arthritis in hand and foot joints, the time course of serum RF content, and systemic disease manifestations). These characteristics were examined with the aid of modern ultrasonic and radionuclide research methods. The evaluations were made by the treatment onset and by months 3, 6, 12 and 18 of the treatment. Analysis of the data obtained attests to a high clinical efficacy of both the drugs exhibiting basic activity which is confirmed by a decrease in the degree of the morphological manifestations of synovitis and extraarticular signs of RA, particularly of myocarditis. A method for following up outpatients to prevent grave complications of chrysotherapy is offered. | |
| 2982178 | [Differential diagnostic value of the hand arteriogram in primary and secondary Raynaud's | 1985 Jan | Arteriograms of the hands were carried out in 348 patients. Functional and organic changes were analysed in an attempt to differentiate primary from secondary Raynaud's syndrome. The value and limitations of this technique are illustrated by a number of examples. | |
| 7252153 | Increased Fc receptor activity in monocytes from patients with rheumatoid arthritis: a stu | 1981 Aug | We studied the binding and catabolic function of adherent monocytes from patients with rheumatoid arthritis (RA) and normal subjects using stable, heat aggregates of IgG125I (A-IgG) as a model for soluble immune complexes. Scatchard plots of 4 degrees C binding data showed that RA monocytes had increased binding avidity and higher maximal binding capacity for A-IgG compared with monocytes from normal subjects. These data suggest that RA monocytes have increased numbers of Fc receptors for IgG, although a concomitant increase in the avidity of individual Fc receptors could not be excluded. At 37 degrees C, RA monocytes; kinetic analysis suggested that increases in catabolized A-IgG were due to increased binding of A-IgG with no change in the fractional rates of catabolism. Latex titers of RA patients correlated with the number of Fc receptors detected on RA monocytes. Mononuclear phagocytes from RA patients are often exposed to endogenous immune complexes that may be present in the blood of such patients; immune complexes may stimulate monocytes and possibly other mononuclear phagocytes to increase their capacity to bind and catabolize soluble immune complexes. | |
| 6971488 | Antibodies against polyriboadenylic acid in systemic lupus erythematosus and rheumatoid ar | 1981 | An enzyme-linked immunosorbent assay (ELISA) for the demonstration of class-specific antibodies against polyriboadenylic acid (poly-(A)) is described. The results revealed the presence of IgG-anti-poly(A) antibodies in 63% (22/35) of patients with systemic lupus erythematosus (SLE) and in 25% (22/88) of patients with rheumatoid arthritis (RA), the mean antibody level being significantly higher in the SLE patients. Anti-poly(A) antibodies of IgM class were seen in 15 and 17% of the patients, respectively. The prevalence of anti-poly(A) and anti-ssDNA antibodies of IgG class was similar in the patients with SLE, but the occurrence of antibodies against poly(A), DNA and extractable nuclear antigens varied independently of each other. In the RA-patients, a positive correlation was seen between the levels of IgG-anti-ssDNA and IgG-anti-poly(A) antibodies. | |
| 3001922 | [Activation of T lymphocytes in the blood and joints of patients with rheumatoid polyarthr | 1985 Jul | The proportion of T Lymphocytes with receptors for interleukin 2 is increased in the blood, the synovial fluid and, in particular, the synovial membrane in rheumatoid arthritis. However, there is no correlation between the percentage in blood and the percentage in the joints. The helper T lymphocytes are proportionately more activated than the suppressor T lymphocytes. | |
| 421967 | Salicylsalicylic acid revisited: a multicentre study. | 1979 | Twenty-eight medical specialists (internists, rheumatologists) selected 102 primarily arthritic patients for a two-week efficacy and safety field study of salicylsalicylic acid. Data were gathered on pain, morning stiffness, range of motion, serum salicylate concentration, erythrocyte sedimentation rate (ESR) and gastro-intestinal bleeding before and after a 15-day drug trial. Results showed a 67% favourable clinical response in the physician's global evaluation and a 60% improvement in pain; the drug itself was well tolerated by 96% of patients. Response correlations with morning stiffness and range of motion were equivocal. Of fifty-four patients examined before and after treatment for intestinal bleeding, only two (3.7%) had detectable faecal blood loss. Good clinical response had a statistically significant association with serum drug concentrations of 13.6 to 13.8 mg%; unsatisfactory response was noted in those patients with mean serum salicylate levels of 8.6 mg%. ESR decreased or was unchanged in thirty-five patients with satisfactory clinical response and in fourteen patients with unsatisfactory response. | |
| 666879 | Association of systemic lupus erythematosus and SLE-like syndromes with hereditary and acq | 1978 Jun | The most prominent association of rheumatic diseases with hereditary complement deficiency is systemic lupus erythematosus (SLE) and discoid lupus erythematosus with homozygous C2 deficiency in females. The lupus disease in these patients differ from classic lupus in 1) the increased incidence of discoid lesions, 2) the low incidence of renal disease, 3) the low or absent titers of antibodies to native DNA, and 4) the infrequent finding of immunoglobulin and complement in skin lesions. The strong positive linkage disequilibrium between C2 deficiency and HLA genes raises the possibility that genes other than those determining C2 levels may have the primary role in determining predisposition to disease in these patients. However, the finding of similar diseases in certain patients with hereditary angioedema and SLE-related syndrome who have acquired deficiency of the early components of complement supports a primary role of the C2 deficiency gene in predisposing to lupus disease in these patients. | |
| 1095794 | Ibuprofen or aspirin in rheumatoid arthritis therapy. | 1975 Jul 28 | Ibuprofen is a nonsteroidal drug with analgesic, antipyretic, and anti-inflammatory properties that was recently introduced for use in antiarthritis therapy in the United States. In a year-long double-blind multiclinic trial in 885 patients with rheumatoid arthritis, ibuprofen was at least as satisfactory as aspirin, considering both efficacy and tolerance. In the majority of patients, daily doses ranged from 800 to 1,600 mg of ibuprofen and 3 to 6 gm of aspirin. The drugs did not differ greatly in providing relief from arthritis symptoms, but ibuprofen was definitely better tolerated, especially in regard to gastrointestinal complaints. Seven percent of the ibuprofen group dropped out of the study because of adverse reactions, as compared with 16% of the aspirin group; 17% of the ibuprofen group and 31% of the aspirin group had gastrointestinal symptoms. | |
| 1200874 | [Morphological changes in the gingiva in collagen disease, uncomplicated or complicated by | 1975 | Biopsy specimens of the gum of patients with systemic lupus erythematodes, rheumatoid arthritis, and systemic sclerodermia, complicated or not with chronic odontogenous infection, and of 10 those of practically healthy persons with chronic odontogenous infection were studied. In patients with collagenous diseases outside the odontogenous infection foci there were observed considerable lesions of the microcirculatory bed vessels, largely of inflammatory nature.--productive vasculitis of the epithelium and connective tissue of the mucosa proper of the gum. The immunopathological character of the above-mentioned lesions in some cases was confirmed by the immunofluorescent method of investigation. The observed changes in vessels and the connective tissue of the gum in collagenous diseases reflected a locally generalized vasopathy of immune character and systemic disorganization of the connective tissue. Studies of gum biopsy materials in patients with collagenous diseases taken from chronic odontogenous infection foci revealed inflammatory changes in the gum tissues much more serious than in practically healthy people in analogous foci od odontogenous infection. Lesions of the gum in patients with collagenous diseases, not complicated with odontogenous infection, represented a background which aggravated the effect of this infection on the gum. | |
| 6653133 | Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of ar | 1983 | In a 12-week crossover study, a formulation of paracetamol (500 mg) and metoclopramide (5 mg) was compared with paracetamol (500 mg) alone for adjunct analgesia in 39 patients with arthritis. Most were on stabilized therapy with anti-inflammatory drugs and all had a history of a tendency to develop gastro-intestinal symptoms. Patients were allocated at random to receive 2 tablets 3-times daily of either treatment for 6 weeks and were then crossed over to the alternative treatment at the same dosage for a further 6 weeks. The results showed that the paracetamol/metoclopramide formulation appeared more effective as an analgesic than paracetamol alone and gave a highly significant reduction in the mean score for upper gastro-intestinal symptoms when compared with paracetamol. There were no side-effects associated with the metoclopramide component. It is concluded that the paracetamol/metoclopramide formulation is a suitable adjunct analgesic for osteoarthritis and rheumatoid arthritis in those patients prone to gastro-intestinal disturbance. | |
| 3938944 | Comparison of three immunoassays for C-reactive protein determination. | 1985 | Three widely used immunoassays for C-reactive protein (CRP) determination (RID. RIEP and LN--Behring) were compared. According to the CRP calcium dependent structural changes or ligand binding properties two buffer systems, Ca2+ rich and Ca2+ depleted, were used in all methods. In RID and RIEP mean values of studied samples were higher when Ca2+ depleted buffer was used (r = 0.94 and r = 0.88, respectively). However, in LN mean values of studied samples were higher when Ca2+ rich buffer was employed (r = 0.923). Comparison of RID and RIEP showed better correlation when Ca2+ depleted buffer was used with r = 0.913 and regression equation y = 0.92 chi + 2.76. Comparison of RID with LN gave similar results as in the case of RIEP and LN. In both cases mean values of studied samples were much higher in LN. Best correlation between RID and LN was obtained when RID was run in Ca2+ depleted buffer and LN performed in Ca2+ rich buffer (r = 0.845, y = 1.25 chi + 18.4). When RIEP and LN were compared highest correlation was obtained when Ca2+ rich buffer in both methods had been used (r = 0.84, y = 1.45 chi + 33.7). However, comparison of both methods run in Ca2+ depleted buffer yielded better regression equation: y = 1.05 chi + 26.1 with r = 0.795. | |
| 7191306 | [Metabolism and pharmacokinetics of acemetacin in man (author's transl)]. | 1980 | Metabolism and pharmacokinetics of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy]-acetic acid (acemetacin, TV 1322, Rantudil) in comparison to equimolar doses of indometacin was investigated in human volunteers after a single oral application and in rheumatic patients after multiple application. After multiple application (t.i.d. for 10 days) of equimolar doses of acemetacin and indometacin, mean blood level curves. The bioavailability of acemetacin derived from these data, corresponds to that of indometacin, i.e., approx. 100%, whereas after a single dose bioavailability of acemetcin is found to be smaller (66% from blood level, 64% from urine). This difference between single and multiple application is explained by slow filling-up of compartments. Degradation of acemetacin occurs by esterolytic cleavage to indometacin, by O-demethylation and N-desacylation and by partial conjugation of all these compounds to glucuronic acid. Blood level ratios of acemetacin and indometacin are equal after single and after multiple application of acemetacin. Therefore, degradation of acemetacin is not induced after multiple application. After a steady-state has been reached half-life of elimination is 4.5 +/- 2.8 h, which is longer than for indometacin (2.2 +/- 0.5 h). Interindividual differences are in the same range as described for indometacin. | |
| 465098 | Ophthalmologic safety of long-term hydroxychloroquine treatment. | 1979 Aug | Ocular toxicity of long-term hydroxychloroquine treatment was assessed by regular ophthalmologic examinations in 99 patients. No patient developed significant loss of vision or visual field constriction to a white test object. Three patients had evidence of toxicity, but the medication had to be permanently discontinued in only one who subsequently had regression of all abnormalities except visual field constriction to a red test object. Neither duration of treatment nor the diagnosis of systemic lupus erythematosus predisposed patients to toxicity. | |
| 71968 | A long-term assessment of flurbiprofen. | 1977 | A multi-centre open study of flurbiprofen was started in 1971 to provide regular clinical and laboratory data on patients with a variety of arthritic conditions. To date, 1220 patients have received the drug in a dosage varying from 75 mg to 400 mg daily. Flurbiprofen has been shown to be effective in relieving symptoms in the degenerative and inflammatory arthritides and side-effects have not proved a problem. Patients aged 65 years and over appear to tolerate the drug as well as their younger counterparts, an important finding in a group of patients notoriously intolerant of many drugs. | |
| 6417768 | Three assays for the characterization and quantitation of human serum amyloid A. | 1983 Oct | Two different radioimmunoassays (RIA) and an enzyme-linked immunosorbent assay (ELISA) were developed for the quantitation and antigenic characterization of amyloid A (AA) and serum amyloid A (SAA) proteins, and the three assays were evaluated and compared with each other. Sensitivity, reproducibility, effect of denaturation and storage of serum and range of determination were considered. All three assays were found useful, but for different purposes. The most suitable method for the determination of SAA in whole serum was a second antibody precipitation RIA with purified SAA as labelled tracer and standard, and polyclonal rabbit anti-SAA as first antibody. This assay provided SAA concentrations in absolute amounts (mg/l) and acceptable reproducibility without need for prior denaturation of serum. Both advantages and disadvantages of ELISA using monoclonal antibodies to SAA and a solid-phase RIA using AA, SAA, anti-AA and anti-SAA were observed. The three assays were found suitable for antigenic studies of AA and SAA. | |
| 6501984 | [Double contrast arthrography of the shoulder joint]. | 1984 Aug | The shoulder joint consists of the soft as well as the hard components. Therefore, the shoulder arthrography is a very important diagnostic tool. Although both positive and negative contrast arthrography have been critically studied, there has been little literature on the double contrast arthrography. The purpose of this paper is to determine the standard technique of the double contrast arthrography, to describe arthrographic findings and to assess its clinical effectiveness of this method. Firstly, the author macroscopically examined the anatomical specimens and molded the interior of the joints with Mercox in the various arm positions. From this experiment, the author correlated the anatomical structures with the shadows on the double contrast arthrogram. Secondly, the arthrography was performed in the normal young adults to determine the ideal volume of the contrast media and the standard positioning of roentgenography. The standard findings were obtained from the arthrograms of normal adults. Thirdly, the author performed the double contrast arthrography to the various shoulder disorders based on the previous experiments to determine the effectiveness of this method. It was concluded as follows pertaining to the double contrast arthrography of the shoulder: The ideal volume of the contrast media is the combination of 1.0-1.5 ml of 76% Urografin and 10-12 ml of room-air. The minimal standard projections needed are antero-posterior views in internal and external rotation, scapular Y view in standing position and axillary view in supine position. This method provides many informations about the interior of the joint and enables us to build up three-dimensional image. This is best indicated to examine the anatomical changes in the disturbance of the anterior capsular mechanism. | |
| 3917937 | Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated with | 1985 Jan 21 | Recombinant immune interferon, (interferon-gamma, IFN-gamma) inhibits types I and III collagen synthesis by rheumatoid synovial fibroblast-like cells in culture. This decrease is associated with a decrease in the levels of types I and III procollagen mRNAs in these cells as measured by dot blot hybridization. In the control synovial cells the level of alpha 2(I) mRNA is disproportionately high compared with that of alpha 1(I) or alpha 1(III) mRNA, and IFN-gamma suppresses the level of alpha 1(I) and alpha 1(III) mRNA to a greater extent than that of alpha 2(I) mRNA. The lymphokine, IFN-gamma, may thus have a role in the regulation of collagen synthesis in inflammatory joint disease and other conditions. | |
| 6773530 | Acute nongonococcal infectious arthritis. Evaluation of risk factors, therapy, and outcome | 1980 Aug | A retrospective analysis of 71 nongonococcal joint infections in 63 patients is reported. Staphylococcus aureus was isolated from 59% of the patients. Five patients died as a result of infections. The outcome in Gram-negative joint infections was similar to the overall outcome in the entire series of patients. All 11 joints with infected prostheses ultimately required removal of the prostheses. All patients were treated with appropriate parenteral antibiotics, and surgical intervention was used in 40 joints. Six patients underwent surgical treatment because of inability to sterilize the joint with antibiotics and because of repeated joint aspirations. The outcome with surgical intervention was good only in patients younger than 16 years of ages. Medical therapy (parenteral antibiotics and frequent joint aspirations) led to good results in 74% of the patients. Outcome of joint infection was also influenced by factors which contribute to impaired host resistance. | |
| 6259211 | Elevated levels of antibodies to Epstein-Barr virus antigens in sera and synovial fluids o | 1981 Apr | The frequencies and levels of antibodies to Epstein-Barr virus (EBV)-specific antigens were determined in paired sera and synovial fluids from patients with rheumatoid arthritis (RA) and in sera from patients with other connective tissue diseases; i.e., systemic lupus erythematosus, progressive systemic sclerosis, and osteoarthritis (OA). The specimens were also tested for the presence of antibodies to RA-associated nuclear antigen. Compared to healthy controls, the patients' sera showed increased frequencies of elevated antibody titers (>/=320) to Epstein-Barr viral capsid antigen, a correspondingly enhanced (twofold to threefold) geometric mean titer, and an increased frequency of antibodies at elevated titers (>/=10), usually to the restricted component and rarely the diffuse component of the early antigen complex. Levels of antibody to the EBV-associated nuclear antigen were within the normal range. Enhancement of antibody titers was more pronounced in seropositive RA patients (i.e., positive for rheumatoid factor) than in those who were not. Enhancement was also found in systemic lupus erythematosus and progressive systemic sclerosis. Antibody to RA-associated nuclear antigen was detected at an increased frequency only in the group of seropositive RA patients (90%), as compared to 8-15% in the other connective tissue diseases and 6-8% in healthy controls. The antibody titers in the synovial fluids equaled or were at most twofold higher or lower than those in the sera. In addition, levels of EBV-specific antibodies were studied serially over a period of 6-10 mo in patients with RA and OA. Parameters of disease activity were determined and compared to antibody levels. EBV-specific antibodies in sera of OA patients remained constant and within normal limits throughout the study. Although EBV-specific antibodies were often elevated in RA patients, they also remained constant, with the exception of three patients, who showed gradual increases in one of the four antibodies, which did not correlate with disease activity. | |
| 6284664 | Messenger function of prostaglandins in cell to cell interactions and control of proteinas | 1982 | Destruction of joint structures in arthritis may result from failure of normal mechanisms controlling interactions among cells of the various tissues of the joint. Normal synovium in culture produces less prostaglandin E (PGE) and collagenase than rheumatoid. When rheumatoid synovium is dissociated into cells, the adherent cell cultures rapidly lose the ability to synthesize large amounts of PGE and collagenase and become indistinguishable from normal synovial cells. A mononuclear cell factor (MCF) derived from supernatant media of cultured human blood mononuclear cells and a 'synovial factor(s)' (SF) from cultures of either normal or rheumatoid synovial fragments both stimulate production of PGE and proteinase by cells derived from human synovium, cartilage and bone. The activities of factors which may be present in these stimulatory supernatants may be unmasked in vitro when they are removed from the normal control present in vivo. Normal synovium probably contains cells which, with the appropriate stimulus, may be recruited to participate in joint tissue degradation. Normal connective tissue turnover may also be controlled by a neutral metallo-proteinase inhibitor (TIMP), which is produced in considerable amounts by normal synovium, but which cannot be detected in cultures of rheumatoid synovium. While corticosteroids inhibit the production and action of MCF and SF, they stimulate production of TIMP by normal or rheumatoid synovial tissue in vitro and may contribute to the endogenous control mechanisms. PGE may also have a modulatory role in these cellular interactions. |