Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1101375 | Comparative double-blind trial of intra-articular injections of two long-acting forms of b | 1975 | Two injectable betamethasone preparations, betamethasone dipropionate/betamethasone phosphate and betamethasone acetate/betamethasone phosphate were compared in a controlled trial on 22 "matched patient pairs" with rheumatic diseases. The two preparations were injected intra-articularly in knee joints affected by active synovitis. The time until onset of action and the duration of clinically adequate anti-inflammatory effect were recorded. All injections produced clinically significant effects. The interval before recurrence of symptoms varied from 2 days to more than 3 months. The dipropionate form showed statistically significantly longer duration of action. No difference was noted in the time until onset of action. Local side effects were not observed. The double-blind method of clinical evaluation proved useful in comparing duration of action between long-acting corticosteroids. | |
| 6382428 | The lateral chest radiograph in the assessment of nonpulmonary health and disease. | 1984 Sep | The lateral chest radiograph contains a wealth of data on the status of the thoracic cage, pleura, heart, pericardium, bronchi, and upper abdomen. The appearances of slightly oblique projections deviating from the "true" lateral projection are reviewed. Careful attention to these common variations of projection is advocated. | |
| 6207959 | Nephelometry of acute-phase glycoproteins by binding to concanavalin A. | 1984 Nov | Nephelometry of serum acute-phase glycoproteins by binding to concanavalin A (con-A) was compared with assays for haptoglobin and alpha 1-acid glycoprotein, and for C-reactive protein. The cutoff points for positive reactions were determined on the basis of results for a random sample (n = 130) from a middle-aged population. The sensitivity of the con-A binding assay compared favorably with that of individual acute-phase glycoproteins in a follow-up cohort of 198 patients with inflammatory joint diseases. Unlike the case in many individual acute-phase glycoprotein assays, the distribution of con-A binding values in healthy subjects is remarkably symmetrical, allowing an easy distinction between abnormal and normal values. | |
| 2423053 | Lectin inhibition system for determination of concanavalin A glycoprotein complexes dissoc | 1985 | A new system for lectin-glycoprotein complexes dissociation constants (K) determination is presented. The system is based on agarose affinity electrophoresis where equal lectin (Con A) concentrations are inhibited by variable specific sugar (alpha-methyl-mannoside) amounts. Moreover, the system allows lectin-sugar inhibition constants (Ki) studies. For determination of mechanisms as well as K and Ki values calculations mathematical equations are developed. Values of K for two variants of alpha 1 acid-glycoprotein, two variants of alpha 1-antitrypsin, one variant of alphafetoprotein and Ki for Con A-alpha-MM are calculated according to the introduced equations and compared in a computed system. Moreover, the influence of sugar on lectin-glycoproteins interaction is demonstrated and discussed. | |
| 6218857 | Influence of previous gold toxicity on subsequent development of penicillamine toxicity. | 1982 Aug 28 | The incidence of penicillamine toxicity was determined in 250 patients who had never previously received gold, 76 patients who had received gold without toxic reaction, and 79 patients with a previous history of gold toxicity. The results suggest that there may be a higher incidence of penicillamine toxicity in patients who have previously shown toxic reactions. The interval between stopping the gold and starting the penicillamine did not influence incidence of toxicity. The development of a rash during gold treatment does not seem to influence the development of a rash during penicillamine treatment, but patients who have had proteinuria or bone-marrow depression during gold treatment may have an increased likelihood of developing a similar side effect with penicillamine. | |
| 176844 | [The potentiating effects of azathioprine and azapropazone on the enzyme activity in exper | 1976 Jan | The influence of prednisolone, azathioprine, and azapropazone on the activity of collagen peptidase, acid phosphatase (complete), and the lactate dehydrogenase of granulation tissue was studied using a model of proliferative inflammation i.e. the cotton-granuloma in rats. The authors observed significant decreases in the activities of the collagen peptidase and acid phosphatase during treatment with prednisone and under combined treatment with azathioprine and azapropazone. In contrast, administration of either azathioprine or azapropazone by itself caused no changes in these enzyme activities as compared with a control group. These studies suggest that the last mentioned drugs potentiate each other in their inhibiting effect upon these enzyme activities. Whether or not these findings are of importance in the clinical treatment of chronic bacterial inflammations must be studied in further trials. | |
| 1093368 | Avulsion injuries in patients receiving corticosteroids. | 1975 Jun | Minor trauma often produces avulsion injuries to the skin and soft tissue of patients who are receiving corticosteroid therapy on a continuing basis. Effective emergency management of these wounds reduces the duration of disability for the patient. Early grafting is a more conservative course in terms of predictable patient recovery than watchful waiting. The most important aspects of this treatment are immediate grafting and sufficient immobilization of the graft by the dressing. | |
| 6365028 | Gold-associated nephropathy. | 1984 Mar | Renal biopsy specimens from 11 cases of gold-associated nephropathy were studied by light, immunofluorescence, and electron microscopy. Seven biopsy specimens disclosed the typical glomerular lesions of membranous nephropathy. Four cases disclosed other patterns of glomerular injury, including minimal-change nephrotic syndrome. Although a membranous pattern of immune complex deposition is the most frequent type seen in gold nephropathy, our data indicate that other patterns of immune complex deposition may occur in renal biopsy specimens of patients receiving gold therapy. | |
| 950630 | Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effec | 1976 Jun | Azathioprine was administered to 25 patients with severe, progressive polyarthritis in a mean dose of 1.4 mg/kg daily. Synovitis improved in 12 patients. Psoriasis and vasculitis were also ameliorated. The therapeutic response did not correlate with dose, concomitant steroid therapy or leukopenia, the latter occurring in nine patients. Carcinoma developed in two patients, after four and nine months of treatment respectively. Low dose azathioprine therapy may be useful in the management of some patients with refractory polyarthritis, but the unsettled issue of oncogenesis requires further investigation. | |
| 684354 | [Dosage of ionized calcium in osteo-articular pathology]. | 1978 Jun | The dosage of calcium ionized serum using a selective electrode, was performed in a series of controls and patients with osteo-articular diseases. Normal values were 43 mg/l between 20 and 50 years of age, and 41 mg/l after 60 years. The level of ionized calcium, when given as a percentage of total blood calcium, did not decrease with age (normal value : 44%). It was increased in hyper-parathyroidism, rhumatoid polyarthritis and lytic bone metastasis. It did not vary in Paget's disease, osteoporosis, osteomalacia, condensing metastasis, Kahler's disease and spasmophilia. The ionized calcium in definitely diminished in hypoparathyroidism. | |
| 6093509 | Inhibition of neutrophil activation by nonsteroidal anti-inflammatory drugs. | 1984 Oct 15 | Nonsteroidal anti-inflammatory drugs are thought to prevent inflammation in rheumatoid arthritis by inhibiting prostaglandin synthesis. This observation does not explain, however, why nonsteroidal anti-inflammatory drugs are able to control inflammation caused by other mediators. To determine whether nonsteroidal anti-inflammatory drugs also exert an effect on neutrophil activation, in vitro and in vivo studies were undertaken. Aggregation, superoxide anion generation, and lysosomal enzyme release were assessed. The nonsteroidal anti-inflammatory drugs were found to inhibit these neutrophil responses, but the patterns of inhibition varied from drug to drug. These findings suggest that nonsteroidal anti-inflammatory drugs may have direct effects on neutrophil activation that are independent of their shared inhibition of prostaglandin synthesis. | |
| 6137275 | Gamma-glutamyltranspeptidase levels as an aid in the management of human cancer. | 1983 Nov 1 | Plasma gamma-glutamyltranspeptidase (GGTP) levels were measured in 435 cancer patients, 120 healthy controls, 15 patients with systemic lupus erythematosis, and 10 patients with rheumatoid arthritis. The mean GGTP activity of all cancer patients studied, with the exception of malignant lymphoma, was significantly elevated compared to control values. Several patient groups were retrospectively analyzed to determine whether GGTP levels correlated with clinical status. Patients who were disease-free had GGTP levels in the normal range, whereas patients with metastases had elevated levels. Serially increasing GGTP levels were associated with disease progression and death. Persons who remained free of disease had serial GGTP levels within the normal range. Furthermore, decreasing levels were associated with response to therapy. These results indicate that GGTP levels may have prognostic value in various human malignancies. | |
| 773499 | Four new anti-inflammatory drugs: responses and variations. | 1976 May 1 | Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen. Fenoprofen and naproxen were slightly more effective than the other two drugs but there were striking individual variations in response. Groups of patients could be identified who preferred each of the four drugs. The commonest side effects were those related to the upper gastrointestinal tract; these showed individual variation and seldom occurred with more than one or two of the drugs. Side effects were least common with ibuprofen and naproxen. Since naproxen combined greater effectiveness with a lower incidence of side effects it must be regarded as the first choice among these drugs. It may be necessary to try several drugs before finding the right one for a particular patient. | |
| 535259 | Arthroplasty of the knee. | 1979 Nov | A stable polycentric knee mechanism which allows axial rotation as well as simulating other knee movements was introduced into clinical use in 1971. The surgical and mechanical problems that presented over the past 7 1/2 years have greatly helped in improving our understanding of knee reconstruction and design. A patient satisfaction rate of 95% compares favorably with the results achieved with hip arthroplasty but the complexity of knee reconstruction far outweights that of the hip. | |
| 119643 | Radioimmunoassay for type III procollagen peptide and its application to human liver disea | 1979 Dec | A sensitive and specific radioimmunoassay was developed for the precursor-specific peptide segment located at the amino end of bovine type III procollagen. Human material showed high cross-reactivity in this assay. Two forms of human procollagen peptides were detected in body fluids. The larger peptide (45K) was found in serum and ascites, and resembled the whole precursor-specific segment which is presumably released from human type III procollagen by a single enzymatic cleavage. The smaller peptide (10K) was found mainly in urine indicating that further degradation of circulating procollagen peptides is required prior to their passage through the kidney. Compared to peptide concentrations in normal human serum two to twenty-fold increases were observed in all patients with alcoholic liver disease, in fifteen of seventeen patients with acute hepatitis, and in ten of fourteen patients with chronic active hepatitis. Much higher levels were detected in ascites fluid. Patients with rheumatoid arthritis and other diseases showed far smaller elevations of the serum peptide. In alcoholic liver disease peptide levels correlated well with inflammation and necrosis observed in liver biopsies, but not with other laboratory parameters. | |
| 1173776 | [Effect of naproxen on DNA synthesis and DNA repair of human lymphocytes in in vivo experi | 1975 Feb | This investigation was conducted in order to evaluate the possibility of late defects caused by drugs. After their base-line blood levels had been assessed, 3 patients with classical rheumatoid arthritis (according to ARA criteria; American Rheumatism Association) received 500 mg of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) daily (in capsules). At the peak of naproxen blood levels following the first naproxen dose, and once monthly for 7 months, thereafter, blood samples were drawn. After separating the lymphocytes from the whole blood, they were damaged by means of 60-Co. Hydroxyurea was added for the suppression of their semiconservative DNA-synthesis. The incorporation of 3-H-THYMIDINE INTO THE DNA of the cells was measured after radiation at different incubation periods. The results showed normal behaviour of the DNA-synthesis following naproxen administration in all three patients. The DNA-repair capacity was normal in one female patient, but slightly lowered in the remaining two. | |
| 6487396 | Arthritis confined to knee joints. Synovial lymphocyte responses to microbial antigens cor | 1984 Oct | The responses of synovial lymphocytes to Chlamydia/Ureaplasma and to enteric antigens were studied in 31 patients with arthritis confined to knee joints, 15 patients with sexually-transmitted Reiter's syndrome, 9 with enteric Reiter's syndrome, and 24 with rheumatoid arthritis. The frequency of HLA antigens was studied in 28 patients with knee joint arthritis; this group was characterized by elevated frequencies of HLA-A2 and DR1. A subgroup of 8 responders to Chlamydia/Ureaplasma was characterized by an increase of HLA-Bw44 and DR7 or 8, while a subgroup of 8 responders to enteric antigens was characterized by increases of HLA-A1 and DR5. The frequency of HLA-B27 in the groups responding to antigens was 25-30%, less than half the frequency in patients with Reiter's syndrome. | |
| 3912712 | Multicentric reticulohistiocytosis: a report of a case and a review of the pathology. | 1985 Oct | A case of multicentric reticulohistiocytosis (MR) in a 24-yr-old woman is presented. MR is a rare disorder characterized by progressive polyarthropathy and a papulo-nodular skin rash. The diagnosis was established by histological examination of biopsies of erythematous nodules on the fingers which showed circumscribed collections of large mononuclear cells and multinucleate giant cells in the reticular dermis. These were embedded in a fine network of mature fibrous tissue with a scanty lymphocytic infiltrate. Histochemical, immunopathological and ultrastructural investigations confirmed that the large mononuclear cells had the properties of macrophages. The histopathological features of MR are reviewed in the light of current knowledge of macrophage physiology, and evidence for lymphocyte-histiocyte interactions in the pathogenesis of this bizarre granulomatous disorder is presented. | |
| 6385227 | Acute and long-term complications of corticosteroid pulse therapy. | 1984 | Complications caused by pulse therapy (PT) using "suprapharmacological" doses of methylprednisolone (MP) are reviewed. The reported adverse effects vary between 0 and 56% in different series. More intense and prolonged PT seems to result in higher toxicity. An improvement in therapeutic index for PT over oral corticosteroids has been found in two out of three controlled studies on renal transplant rejection. No controlled studies of PT in SLE have been published. Neuropsychiatric reactions occur in both SLE and RA. | |
| 6819108 | Plasma viscosity, haematocrit and red-cell transport. | 1982 Nov | An erythrocyte transport function (ETF) is proposed, as an index of the efficiency of the circulation of red cells. Under defined conditions, this ETF is shown to be proportional to the ratio of haematocrit to whole-blood viscosity (phi/eta), a ratio already used by Chien. The variations of phi/eta with phi, at selected driving pressures in a capillary viscometer, are presented, both for normal and for pathological blood samples. Maximal values of phi/eta appear generally to occur at haematocrits of about 42%, and are strongly dependent upon plasma viscosity. They are also influenced by shear. The concept of 'isograds' (curves of phi/eta against phi at constant velocity gradient) is introduced, and is analysed in technical appendices which also deal with rates of shear in capillary and rotational viscometers when Newtonian or shear-sensitive liquids are measured. |