Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6448525 | [Gold therapy in chronic polyarthritis. Differentiation of allergic and toxic side effects | 1980 Mar | The data from 310 patients treated with gold were analysed. The occurrence of side effects is lower than the average data in the literature: with "Solganal" 21.5%, with "Tauredon" 21%. The clinical importance of the differentiation of toxic and allergic side effects is pointed out. It seems possible to differentiate between the toxic-allergic and the dosage dependent, actually toxic side effects. In cases of toxicity caused by retarded metabolisation the use of the barbiturate enzyme induction made it possible to continue treatment. | |
| 85016 | Is chloroquine obsolete in treatment of rheumatic disease? | 1979 Feb 17 | Retinal changes associated with chloroquine occurred in 22 out of 222 patients on long-term therapy for rheumatic diseases and were related to patient age, total dose, and duration of treatment. Ophthalmic review showed progression of the retinopathy with deterioration of visual acuity in only 1 case while the remainder retained normal vision. The results suggest that the risks of ocular toxicity related to chloroquine therapy are acceptably low. | |
| 1190215 | Yttrium-90 citrate colloid for radioisotope synovectomy. | 1975 Oct | The preparation of an yttrium-90 citrate colloid is described. This formulation localizes in the synovial membrane and thereby eliminates any irradiation received by extra-articular tissues. Yttrium-90 is eluted from Sr-90 bound to a sulphonic acid ion exchange resin. The colloid is prepared using a 3:1 ratio of carrier yttrium and citrate. Contamination with ionic 90Y and ionic 90Sr was less than 1 percent and 0.001 percent, respectively. In the 28 patients studied, all of the injected dose of 90Y remained in the region of the joint. Brief clinical results are presented. | |
| 2932399 | Injectable gold dermatitis and proteinuria: retreatment with auranofin. | 1985 | Seven female patients with classical rheumatoid arthritis (RA), treated successfully with injectable gold salts (Fosfocrisolo ICI, 0.10 g/week, with a serum gold concentration of 200-400 mcg/dl), experienced severe gold side-effects after 3 to 20 months of therapy, requiring their withdrawal from gold despite the good results in both clinical and laboratory findings. Four patients showed mucocutaneous side-effects (2 dermatitis and 2 stomatitis) and three a moderate or severe proteinuria. Renal biopsy was performed in these patients, with a histological picture of membranous glomerulonephritis referable to gold therapy. Remission inducing drug (R.I.D.) therapy being mandatory in patients with a chronic progressive disease, and in view of the previous efficacy of gold salts, the patients were put on oral gold, Auranofin being administered 3 mg b.i.d. Both the mucocutaneous side-effects and the proteinuria ameliorated within 2 to 6 months, and the remission of the disease was maintained. The chemical and pharmacokinetic differences between the above two gold compounds are discussed. | |
| 6972962 | Activated T cells in the synovial fluid of arthritic patients. II. In vitro activation of | 1981 Aug | Lymphocytes isolated from the synovial fluid of arthritic patients were shown to express characteristics of immunoactivated T cells, such as the formation of stable E rosettes and natural attachment to normal and malignant cells. During 5 days incubation in autologous serum, the synovial T cells reverted to resting state. If, however, the synovial serum was present in the culture, the activated state was maintained. The blood lymphocytes of these patients did not have the markers of activation. When blood lymphocytes were mixed in vitro with the autologous synovial T cells, a proportion of them acquired the capacity to form stable E rosettes and to express natural attachment. Synovial polymorphonuclear cells or synovial serum were without effect on the blood lymphocytes. This phenomenon may represent an in vivo mechanism for the perpetuation of the cellular immune reactivity in the joint cavity. | |
| 790547 | Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis. Results of a multi-cen | 1976 | In a multi-centre, double-blind, cross-over trial comprising 38 patients with rheumatoid arthritis, ketoprofen was given at a dosage of 150 mg daily and phenylbutazone at a dosage of 300 mg daily, each for 2 weeks. On the basis of patient preference, general evaluation of the disease, morning stiffness, pain on movement and need for analgesics (dextropropoxyphene), it could be concluded that there was no significant difference between phenylbutazone and ketoprofene, although a tendency to more frequent and severe side-effects was seen with pehnylbutazone. | |
| 518715 | Infection in patients with systemic lupus erythematosus. Association with a serum inhibito | 1979 Dec | We have found subnormal amounts of chemotactic activity in zymosan-treated sera from 13 of 29 patients with systemic lupus erythematosus (SLE). As an explanation for this abnormality, the presence of a uniquely specific, heat-stable inhibitor of complement (C5)-derived chemotactic activity has been documented in sera from 11 of these patients. Sera from 2 other patients contained elevated levels of nonspecific, heat-labile chemotactic factor inactivator (CFI) activity. The serum from 1 patient contained the heat-stable inhibitor as well as elevated levels of CFI. Patients with SLE whose sera contained the heat-stable inhibitor had more active disease clinically, but otherwise they were indistinguishable from patients without the inhibitor. When patients with the heat-stable inhibitor improved clinically, this usually was accompanied by a decrease in serum inhibitory activity. Only one episode of bacterial infection was observed among 16 patients with SLE whose sera yielded normal amounts of chemotactic activity after treatment with zymosan. In contrast, 7 of 11 patients with SLE whose sera contained the heat-stable inhibitor suffered serious bacterial infections. The presence of this heat-stable inhibitor in sera from some patients with SLE may contribute, in part, to their increased susceptibility to infection. | |
| 6658396 | Sebaceous glands in the buccal mucosa in patients with rheumatic disorders. | 1983 | When seeking oral lesions in patients with rheumatic disorders (RD), the most frequent discernible finding in the buccal mucosa seems to be sebaceous glands (SG). The purpose of the present study was to examine whether or not SG are associated with RD, especially Reiter's syndrome (RS). Observation of SG in the buccal mucosa took place by thorough inspection of 50 males and 80 females suffering from RD. Controls were 237 males and 231 females from an oto-rhino-laryngologic clientèle. Further rheumatological examination was made of 12 males and 7 females from the control group who showed positive SG findings. Biopsies from SG were performed for 9 patients suffering from RS. SG were observed in 24 males (48%) and 35 females (43.8%) among patients with RD and in 19 males (8%) and 8 females (3.7%) in the control group (p less than 0.001). Rheumatological examination of the above-mentioned 12 males and 7 females revealed either a history and/or objective signs of RD, most often RS, in 7 males (58.3%) and 6 females (85.7%). The histological pattern of SG was different from that of the mucocutaneous lesions of RS. The results speak in favour of a close association of oral SG and RD, with a certain emphasis in the direction of RS. SG seem to be an important additional non-specific clinical sign in the protean picture of rheumatic disorders. | |
| 7668 | The pharmacology of flazalone: a new class of anti-inflammatory agent. | 1976 Aug | The anti-inflammatory activity of flazalone, a unique chemical drug, is described. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits. The pattern of anti-inflammatory activity does not allow one to classify this drug in the usual groups. | |
| 6605109 | Detection of antibodies to histones in human systemic lupus erythematosus and in murine lu | 1983 May | An enzyme-linked immunosorbent microassay (micro-ELISA) was improved for the detection of anti-histone antibodies. Detection of these antibodies in autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerodermitis sclerosis (SCL), showed a positive correlation between the presence of antinuclear antibodies detected by indirect immunofluorescence and the level of anti-histone antibodies (p less than or equal to 0.02) having anti-H1 (p less than or equal to 0.001) and anti-H2B (p less than or equal to 0.01) specificities. These antibodies were more frequently detected, and at a higher level, in human SLE than in RA and SCL. Anti-H1 and anti-H2B (and less frequently anti-H3) antibodies were also found in mice with lupus-like syndrome (MRL/1, PN and Swan). Their level rose with age and they were prevalent in the severe forms, especially in MRL/1 and PN. | |
| 7458607 | A review of early mortality and morbidity in elderly patients following Charnley total hip | 1980 | To assess the effects of ageing upon the outcome of total hip replacement, the in-patient records of 100 elderly patients who had undergone Charnley hip replacement procedures within the last decade were reviewed. There were 74 women and 26 men and their mean age was 80 years. Osteoarthritis was the cause of hip disease in 94 patients and rheumatoid arthritis the cause in the remaining six patients. The early mortality and morbidity rates were 4% and 77%, respectively, and the average duration of hospital treatment 42 days. Infection was the commonest post-operative complication followed by mental confusion and adverse drug reactions; multiple complications were a frequent finding. Avoidable complications are indicated and recommendations made regarding the pre-operative, operative and post-operative management of elderly patients. | |
| 1097473 | Interaction in vitro between synovial cells and autologous lymphocytes and sera from arthr | 1975 Jul | Synovial cells from patients with rheumatoid arthritis (RA) when grown in vitro in media supplemented with 20% fetal calf serum failed to show any difference in growth rate, life span, uptake of tritiated thymidine or cellular and nuclear characteristics when compared with synovial cells from patients with osteoarthritis or other joint diseases grown similarly in 20% serum enriched medium. There was also no evidence that lymphocytes and/or sera from RA patients were more cytotoxic to autologous synovial cells than sera and/or lymphocytes from OA patients. It is unlikely that antisynovial antibodies or lymphocytes from RA patients act as triggers for synovial damage. | |
| 6841533 | Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells a | 1983 Jan 14 | The amount of chloroquine and desethyl-chloroquine was determined in samples of total blood and in blood cell fractions from three normal subjects after one oral dose of 1000 mg of chloroquine diphosphate. About 70-85% of the total whole blood content of chloroquine and its metabolite desethyl-chloroquine were recovered in blood cells isolated from whole blood, indicating that these compounds have a high cell/plasma concentration ratio. They were mainly present in thrombocytes and granulocytes. A study of 40 patients taking chloroquine regularly as a treatment for rheumatoid arthritis showed significantly higher concentrations of chloroquine and desethyl-chloroquine in serum than in plasma. The concentration of chloroquine was about two times higher in serum than in plasma and for desethyl-chloroquine the concentration was about four times higher in serum than in plasma. These differences may be explained by a release of chloroquine and desethyl-chloroquine from thrombocytes during the coagulation of blood. The practical implication of the results is that the samples taken for chloroquine determination must be clearly identified as serum or plasma. | |
| 137737 | Treatment of peripheral corneal ulcers by limlial conjunctivectomy. | 1976 Oct | We report the rapid healing of several cases of marginal corneal ulceration of various aetiologies after the excision of a 4 to 7 mm strip of adjacent limbal conjunctiva. After conjunctivectomy the remaining conjunctiva was loosely recessed (without sutures). In one case with coexisting scleromalacia, we excised strips of adjacent bulbar conjunctiva with equally good results. Some of the cases had failed to respond to other modes of treatment including topical collagenase inhibitors. One case responded to peritomy and cryotherapy to the ulcer edges, but we have abandoned this treatment in favour of conjunctival excision. Limbal conjunctivectomy with recession is presumed to act by eliminating conjunctival sources of collagenase and proteoglycanase. | |
| 6880415 | [Immunopathologic aspects of chronic erysipelas polyarthritis in swine]. | 1983 May | Chronic erysipelas polyarthritis in pigs is considered to be an animal model closely resembling human rheumatoid arthritis. In an experimental study using SPF pigs infected with Erysipelothrix rhusiopathiae several immunopathological aspects were studied for up to 14 months after infection. After an initial febrile phase a progressive polyarthritis and discospondylitis developed at 2 weeks after infection. Quantitative determination of IgG and IgM revealed a significant increase in these immunoglobulins both in the serum and the synovia from arthritic joints. Arthritic joints containing viable Erysipelothrix bacteria at termination of the experiment have a higher content of IgG and IgM than bacteriologically negative joints. During the entire experiment the rheumatoid factor titer, determined by the Waaler Rose test, remained relatively low with increases and decreases. The Erysipelothrix antibody titers are highly significant. The total complement activity in the serum increases discontinuously and shows fluctuations similar to those of the rheumatoid factor titer. The highest enzyme activities of acid phosphatase and lactate dehydrogenase are demonstrable in the synovial fluid of arthritic joints with positive bacteriological or immunohistological findings. These joints also have the greatest numbers of IgG-producing plasma cells. By means of immunohistological methods Erysipelothrix antigen can be demonstrated in macrophages of the proliferating synovial membrane. Finally, there is a discussion of the pathogenic significance for the perpetuation of chronic polyarthritis of Erysipelothrix persisting in arthritic joints in spite of focal immune reactions. | |
| 7364805 | The spherocentric knee: a re-evaluation and modification. | 1980 Apr | The purpose of this study was to assess prospectively the initial results of total knee replacement with the standard spherocentric component and to identify retrospectively the pathogenesis of any unsatisfactory results. As a consequence of this study, the femoral component was modified. Thirty-six knees were reviewed twenty-two to fifty-two months after a standard spherocentric total knee replacement, with a mean follow-up of thirty-five months. Twenty-five (70 per cent) of the knees had significant relief of pain and improved function. Eleven knees were not improved because of confirmed loosening in five, supracondylar fracture in two, infection in one, and suspected loosening in three. Ten of these eleven complications became manifest within the first postoperative year. Alignment in the coronal plane was not consistently precise and hyperextension was a recurrent problem in twelve of the thirty-six knees. A modification in the femoral component was made: the stem was lengthened to 10.0 centimeters and the body was reoriented so that there was 5 degrees of valgus and 15 more degrees of posterior rotation than the original design. This modified prosthesis was used in twenty-five additional knees, with definite improvement in alignment, but the follow-up was insufficient to ascertain the effect of the modification on lossening and fracture. | |
| 154987 | Dependence of collagen synthesis by embryonic chick tendon cells on the extracellular conc | 1978 | An agent in rheumatoid synovial fluid which stimulates collagen synthesis by embryonic chick tendon cells was identified as glutamine. The stimulating effect was observed only at a subnormal concentration of proline (0.02 mM). The concentration of glutamine in rheumatoid synovial fluid is about 2.5 mM but it falls rapidly during storage even at -20 degrees C. Collagen synthesis is shown to depend on the extracellular concentrations of glutamine and proline in addition to any connective tissue activating factors. | |
| 6688509 | The affected sib method. II. The intermediate model. | 1983 Jul | An iteration procedure is outlined which uses HLA haplotype sharing data from sib pairs in which both sibs have the disease of interest. The procedure allows estimation of the degree of dominance of the HLA linked 'disease' allele, and its frequency in the population, for intermediate models where it is assumed that individuals who do not have at least one copy of the 'disease' allele do not contract the disease. Parameter estimates from sib-pair data on multiple sclerosis, insulin dependent diabetes mellitus, haemochromatosis, coeliac disease juvenile rheumatoid arthritis, and Graves' and Hashimoto's diseases are given. | |
| 6943959 | A comparative study of platelet reactivity in arthritis. | 1981 | We utilized a standardized in vitro method which employs transmission electron microscopy to monitor the degree of surface activation (cytoplasmic spreading) and amount of aggregation displayed by platelet populations from 314 patients with one of five distinct rheumatic diseases and from 72 normal subjects. The percentage of patients in each group whose platelet populations were hyperactive was as follows: polymyalgia rheumatica, 75 percent; scleroderma, 65 percent; primary gout, 61 percent; rheumatoid arthritis, 57 percent; and degenerative joint disease, 40 percent. Pair-wise contrasts performed after an analysis of variance suggest the following differences and similarities: (1) the mean differential platelet count of the normal subjects differed from that in each disease state; (2) the platelet responsivity in patients with degenerative joint disease most closely resembled that in normal subjects; (3) the platelet response in polymyalgia rheumatica plus temporal arteritis was the most abnormal; and (4) platelet response in scleroderma, rheumatoid arthritis, and gout closely resembled each other. The increased platelet response in vitro may reflect the in vivo presence of disease-related "risk factors" (hyperuricemia, immune complexes, and atherosclerosis). Those patients with "triggered" platelet populations may be appropriate candidates for antiplatelet therapy. | |
| 6236824 | Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint. | 1984 Sep | Histochemical and ultrastructural studies of bone-cartilage junctions from 21 rheumatoid knee joints have demonstrated the presence of both osteoclasts and chondroclasts. Significant erosions of bone and mineralized cartilage were observed in 15 specimens, and 6 showed localized erosions of unmineralized (hyaline) cartilage. Chondroclasts, defined by their close association with both mineralized and unmineralized cartilage, were morphologically and histochemically similar to osteoclasts. Our observations suggest that these multinucleate cells play a crucial role in subchondral tissue destruction, but that erosion of unmineralized cartilage is primarily the result of synovial pannus tissue. |