Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 373085 | A comparative clinical study of a new antirheumatic agent, tolfenamic acid (Clotam), and p | 1979 | A double-blind crossover study was carried out in 33 patients with rheumatoid arthritis using a new anthranilic acid derivative, tolfenamic acid, and phenylbutazone. Each drug was given in doses of 100 mg 3 times daily. Both periods of treatment lasted 3 weeks. Objective and clinical studies of the antirheumatic effect showed no significant difference between the two forms of treatment. On phenylbutazone treatment, however, there were significantly greater numbers of, and more serious, side-effects (especially dyspeptic symptoms and fluid retention) than on tolfenamic acid treatment. | |
| 1147450 | Thyroid autoimmunity: increased frequency in relatives of insulin-dependent diabetes patie | 1975 Aug | Thyroid antibodies were found significantly more often in insulin-dependent diabetics than in their spouses or in non-insulin-dependent diabetics. The poor correlation between presence of thyroid autoimmunity and duration of disease and the significantly increased prevalence of thyroid antibodies in first-degree relatives of insulin-dependent probands are interpreted to suggest that thyroid autoimmunity in probands with insulin-dependent diabetes is not secondary to diabetes. Since married couples in which both members had thyroid antibodies were not found more frequently than predicted by chance alone, acquired environmental factors are not the sole determinants of familial thyroid autoimmunity in diabetes; it is likely that inherited predisposition is of major importance. Relatives of probands with thyroid antibodies have significantly higher frequency of these antibodies than do relatives of negative probands. This finding suggests that there are several kinds of insulin-dependent diabetes, one of which may be an "autoimmune" disease. | |
| 636665 | Plasma amino acid level in rheumatoid arthritis and ankylosing spondylitis and its variati | 1978 Mar | 28 plasma amino acids of 40 female patients with rheumatoid arthritis (RA), 24 male patients with ankylosing spondylitis (ASp) and 19 controls (14 females and 5 males) were investigated. In RA-patients 19 amino acids showed statistically significant differences to healthy people of which 18 were decreased. In ASp-patients 14 amino acid concentrations were statistically altered whereby 10 showed enhanced values. In female RA-patients and controls a linear dependency between distinct amino acids (threonine, glutamic acid, proline, alanine, citrulline, tyrosine, phenylalanine, ornithine, lysine and 3-methylhistidine) - and advanced age could be demonstrated. | |
| 6333245 | Self-associating IgG rheumatoid factors in MRL/l autoimmune mice. | 1984 Oct | Previous work has shown that the intermediate complexes isolated from the plasma of patients with rheumatoid arthritis are composed of self-associating IgG rheumatoid factors. Mice of the MRL/l strain develop spontaneous autoimmune disease with arthritis that is pathologically similar to human rheumatoid arthritis. Also, the sera of MRL/l mice contain autoantibodies to nuclear antigens as well as IgM and IgG rheumatoid factors. The present studies were done to determine if the IgG rheumatoid factors isolated from these mice undergo self-association. MRL/l mouse sera were categorized into groups A and B based on serum-serum precipitin interactions. Thirteen of 13 MRL/l mice sera examined contained intermediate complexes sedimenting between the 6.6S and 19S components of normal serum by sedimentation velocity ultracentrifugation. There were no differences in the level of intermediate complexes between groups A and B. IgG rheumatoid factors were isolated from the sera of 9 other mice. Upon sedimentation equilibrium ultracentrifugation, these rheumatoid factors underwent concentration-dependent self-association similar to that described for human self-associating IgG rheumatoid factors, although the precise stoichiometry of self-association could not be determined. The IgG rheumatoid factors from group B had higher energies of self-interaction than those from group A. These studies provide additional evidence that MRL/l mice may be the best available animal model for the study of human rheumatoid arthritis. | |
| 975668 | ICLH (Freeman/Swanson) arthroplasty in the treatment of arthritic knee: a 2 to 4-year revi | 1976 Oct | A prospective follow-up using a standardized data recording form was carried out by independent, experienced orthopedic surgeons on a small number (116) of knees operated upon at The London Hospital in the period January 1, 1971 to October 31, 1973. An additional 93 knees have been operated upon at other hospitals and followed prospectively using the same data recording system. A total of 159 knees have been reviewed 2 to 4 years after operation. The complications specific to ICLH arthroplasty have been unremarkable and generally correctable. Two tibial components have sunk and have been revised at The London Hospital. The results show that ICLH arthroplasty has been used to correct satisfactorily flexion deformities up to 70 degrees, valgus deformities up to 45 degrees, and varus deformities up to 35 degrees. (Deformities of greater magnitude can be corrected but were not present among the knees in this study.) The operation may be said to be "worthwhile" with reference to pain in 94 per cent of the knees, with reference to the ability to walk in 80 per cent of the knees, and with reference to the range of movement in 71 per cent. Overall, 47 per cent of the knees had no complaint postoperatively, while a further 47 per cent were improved; thus for 94 per cent the procedure was "worthwhile." | |
| 6177323 | Antibodies to collagen in scleroderma. | 1982 May | Using the enzyme-linked immunosorbent assay (ELISA), we detected antibodies to interstitial (type I) and basement membrane (type IV) collagens in the sera of patients with scleroderma (systemic sclerosis). Antibodies against type IV collagen were found in significant levels in these patients and correlated with the presence of abnormal pulmonary diffusion capacity. Levels of antibodies to type I collagens also correlated significantly with pulmonary diffusion capacity. Absorption of sera with type I or type IV collagens before analysis in the ELISA eliminated reactivity in an antigen-specific pattern, indicating that these antibodies reacted with determinants specific for either type I or type IV collagens. The removal of immune complexes by ultracentrifugation had no effect on serum antibody levels. Autoantibodies to basement membrane and interstitial collagens may participate in the pathogenesis of scleroderma. | |
| 6766523 | Disease-modifying drugs for progressive rheumatoid arthritis. | 1980 Mar | In patients with rheumatoid arthritis who do not respond to therapy with salicylates or nonsteroidal anti-inflammatory agents, stronger and potentially more toxic drugs are then considered. At the present time in the United States, this generally means a trial of hydroxychloroquine, gold, penicillamine, azathioprine, or cyclophosphamide. Each of these drugs is discussed with regard to pharmacology and possible modes of action, pertinent clinical studies, and toxicity. | |
| 317533 | [Physiopathology of rheumatoid psoriasis]. | 1979 Oct | The physiopathology of rhumatoid psoriasis (RP) is poorly known. Besides the genetic factors we study immunological disorders from a series of 51 cases. We found mainly an increase of serum IgA, a decrease of IgM, a low level of circulating immune complexes, sometimes IgG type antiglobulin factor (very seldom IgM type, which explains the sero-negativity) seldom antinuclear antibodies; we found also a diminution of T lymphocytes detected by a decrease of E rosette - forming cells and an increase of the lymphocyte subpopulation forming high avidity EA rosettes, whereas the mitogenic response is normal or slightly decreased in the presence of Con A (not significant). A increased frequency of HLA DRW5 and DRW2 was found but too few cases were studied to make possible a definite conclusion. This immunopathologic profile is compared to that of psoriasis with anthropathy. The relevance of immune disorders in the physiopathology of RP is discussed. | |
| 6626246 | Effect of heavy metals on human rheumatoid synovial cell proliferation and collagen synthe | 1983 Sep 15 | The dose-dependent effects of heavy metals on cell proliferation, collagen synthesis, and non-collagen protein synthesis were studied in early passage cultures of human synovial cells exposed to 1-100 microM concentration of gold, silver, mercury, cadmium or lead for 5 days. The incorporation of [3H]thymidine into trichloroacetic acid insoluble material was inhibited 50% by each of the heavy metals at concentrations between 1 and 10 microM. Gold, lead and mercury (10 microM) decreased the DNA content of the cultures by less than 15%; silver (10 microM) and cadmium (10 microM) resulted in decreased DNA content, which was attributed to cytotoxicity. A dose-dependent inhibition of [3H]proline incorporation into bacterial collagenase resistant (non-collagen) protein was observed after incubation with 10 microM mercury, lead and silver. During incubations with 10 microM gold and cadmium, collagenase resistant protein accumulation increased. All the heavy metals except for gold inhibited collagen accumulation to a greater extent than non-collagen protein accumulation. Gold (10 microM) stimulated the amount of collagen produced per cell, and the percentage of collagen to total protein was increased 50%. The rate of collagen accumulation in medium decreased during incubation with 10 microM silver, mercury, cadmium and lead. The stimulation of collagen synthesis may be a unique property of gold related to the therapeutic indices of gold, compared to other heavy metals, in rheumatoid arthritis. | |
| 3981521 | The effect of serum from patients with systemic lupus erythematosus on the immune response | 1985 Feb | In contrast to influences that act to reduce the function of suppressor T cells, we describe a factor found in the sera of 13/28 patients with systemic lupus erythematosus (SLE) that augments the response of normal donor peripheral blood lymphocytes to stimulation by pokeweed mitogen (PWM) in vitro. This factor was present in 1/2 of our patients with active SLE, but not in normal blood donors; it required the presence of pooled AB serum in the culture medium; was specific for stimulation by PWM and not by phytohemagglutinin, concanavalin A or purified protein derivative; it appeared to act predominantly on B lymphocytes and was neither immunoglobulin nor interferon. This augmentation was seen to a lesser degree with rheumatoid sera, but not with psoriatic arthritis sera or sera of SLE patients on dialysis. | |
| 3970732 | Abnormal calcium and magnesium stores in erythrocytes and granulocytes from patients with | 1985 Feb | The mass fraction of Ca and Mg in isolated erythrocytes and granulocytes was measured using the nuclear microprobe technique. Conspicuous abnormalities were observed in cells from patients with rheumatoid arthritis and other inflammatory arthritides. Compared with the normal cellular content, total Ca was increased an average of 3 times in erythrocytes and 5 times in granulocytes. Total granulocyte Mg was increased about 3 times, whereas erythrocyte Mg was reduced to as much as 60% of normal. These abnormalities were less prominent or were absent in scleroderma patients, except for levels of granulocyte Ca, which were increased more than 3 times beyond normal in this patient group. A significant positive correlation was found between serum haptoglobin and erythrocyte or granulocyte Ca content among these patients, but not between haptoglobin and erythrocyte or granulocyte Mg values. During corticosteroid treatment, a significant increase in erythrocyte Mg and a significant reduction in erythrocyte Ca were noted, but normalization of these levels was not achieved. Granulocyte Ca was also significantly reduced, while granulocyte Mg remained unaltered. Serum levels of Ca and Mg were within normal ranges and were not influenced by corticosteroid therapy. The results indicate that at least Ca abnormalities in erythrocytes and granulocytes are associated with the intensity of the inflammatory process and that the amounts of Ca and Mg in these cells are influenced by potent antiinflammatory therapy. | |
| 6851441 | Platelet associated IgG and immune thrombocytopenia in lymphoproliferative and autoimmune | 1983 | Thrombocytopenia is frequently encountered in patients with lymphoproliferative disorders (LPD) and systemic erythromatosus (SLE) and to a lesser extent in association with other diseases such as rheumatoid arthritis (RA), pernicious anaemia (PA) and autoimmune haemolytic anaemia (AIHA). This report attempts to document the incidence of thrombocytopenia in these disorders, other than that overtly due to malignant infiltration or marrow suppression by drugs and to demonstrate, that in a significant proportion antibody mediated immune destruction of platelets can be confirmed by positive platelet antibody tests. Platelet associated IgG (PAIgG) was measured in all patients by a quantitative enzyme linked assay. Platelet antibodies were found in 11 of 24 (46%) thrombocytopenic patients with LPD, 10 of 16 (62%) patients with SLE and thrombocytopenia, and in all patients with RA and PA who had low platelet counts at the time of study. In addition, elevated PAIgG levels were found in the following non-thrombocytopenic patients: 9 of 43 (21%) patients with LPD, 2 of 12 (17%) with SLE, 2 of 12 (17%) with AIHA, 2 of 39 (5%) with PA and 5 of 61 (8%) patients with RA. The nature and the role of raised PAIgG levels in diseases other than autoimmune thrombocytopenia is controversial. Our reasons for interpreting these as true platelet autoantibodies in this selected group of disorders and the clinical implications of our results are discussed. | |
| 316939 | IgM anti-IgM cold lymphocytotoxins to B cells. | 1979 Dec | Cytotoxic antibodies to B lymphocytes have been shown to be IgM. They are not absorbed by red blood cells and therefore not absorbed by red blood cells and therefore not directed against the I antigen of red cells. They are also not inhibited by mannose, as are certain natural cytotoxins against lymphocytes. Methods for producing purified eluates of IgM anti-IgM antibodies are given. These antibodies are postulated to be immunoregulative by acting on B lymphocytes. | |
| 6161033 | Synovial cell antigens--production of heterologous anti-human synovial cell sera and gener | 1981 | Antisera to cultured human synovial cells were produced in several rabbits by a variety of immunization procedures. The antisera were assayed by a number of immunologic techniques for specificities against live synovial and other fibroblastic cell lines and against additional antigen sources including human serum and synovial fluid, and fetal calf serum. While the antisera reacted well and with the same titers to all synovial cell lines, reactivities varied with several nonsynovial cell lines showing that synovial tissue-derived cells are antigenically different from other tissue fibroblastic cell strains. Also, the major antigens cross-reactive between synovial and certain other fibroblastic cell lines were partially defined as those in or cross-reactive with fetal calf serum and human serum or plasma components. The differential reactivities of the antisera demonstrated that the antibody specificity populations were markedly affected by the immunization manipulations. Methods for analyzing those differences are presented by defining specificity and reactivity indices. The antisera to the synovial cells distinguished 7 electrophoretically distinct reactivities in human serum or plasma, synovial fluid, and in fetal calf serum. 1 antigen was identified as fibronectin, 3 as components of fetal calf serum and 3 additional unidentified human serum cross-reactive antigens. | |
| 60533 | Letter: Marrow aplasia and penicillamine. | 1976 Sep 25 | A prospective study involving 87 patients was carried out to evaluate the necessity for a high dose of contrast material in addition to delayed computed tomographic (CT) scanning for optimal detection of the lesions of multiple sclerosis in the brain. In patients with either clinically definite multiple sclerosis or laboratory-supported definite multiple slerosis, CT scans were obtained with a uniform protocol. Lesions consistent with multiple sclerosis were demonstrated on the second scan in 54 patients. In 36 of these 54 patients, the high-dose delayed scan added information. These results are quite similar to those of a previous study from this institution using different patients, in whom the second scan was obtained immediately after the bolus injection of contrast material containing 40 g of organically bound iodine. The lack of real difference in the results of the two studies indicates that the increased dose, not just the delay in scanning, is necessary for a proper study. | |
| 1163724 | Multicentric reticulohistiocytosis (lipoid dermato-arthritis). An erosive polyarthritis wi | 1975 Aug | Detailed analysis of the progressive roentgenographic changes found in complete serial skeletal surveys of 2 men with multicentric reticulohistiocytosis (MR) have been correlated with pathologic finds and compared to features preivously reported. The lesions of MR predominate in skin and synovium and result in the following characteristic features: (1) sharply circumscribed, rapidly progressive, strikingly bilaterally symmetric erosions spreading from joint margins to articular surfaces; (2) interphalangeal joint predominance; (3) early and severe atlanto-axial involvement; (4) disproportion between severity of joint destruction and mildness of symptoms; (5) absent or minimal periosteal reaction; (6) absent or disproportionately mild osteoporosis compared to the severity of erosions; and (7) prominent, uncalcified soft tissue nodules. Since arthritis often precedes cutaneous manifestations, careful roentgenologic evaluation may play key role in early diagnosis. | |
| 6334888 | Modulation of natural killer cell activity in the rheumatoid joint and peripheral blood. | 1984 Dec | Natural killer (NK) cell activity and its regulation in synovial fluid (SF), synovial tissue (ST), and peripheral blood (PB) was studied in 23 patients with active rheumatoid arthritis (RA). NK activity was reduced in PB (P less than 0.005), SF (P less than 0.002), and ST of patients with RA compared to the PB of 28 healthy controls. NK activity in SF was inversely correlated with disease activity as measured by erythrocyte sedimentation rate (r = -0.561; P less than 0.02). Poly I:C, an interferon inducer, stimulated NK activity in RA patients' PB and SF and control subjects' PB to similar extents. However, augmentation of NK activity by interleukin-2 was significantly greater in SF than in PB of RA (P less than 0.02). Preincubation of mononuclear cells with indomethacin significantly increased the NK activity of normal and RA PB but had no effect on that of SF. These observations suggest that the NK activity may be reduced in both PB and SF of RA and that functional differences between populations of cells with NK-like activity and/or differences in the control or modulation of NK activity exist between PB and SF. | |
| 3967443 | The anatomic total knee resurfacing arthroplasty. | 1985 Jan | The long-term results of total knee arthroplasty are largely dependent on the degree to which the implants and the technique for their insertion duplicate the normal joint anatomy, mechanics, and kinematics. Aberrations in these modalities, occasioned by technical malalignment of the joint or by nonanatomic designing, sizing, or positioning of the implants, are the predominant causes of postoperative limitation of motion and loosening of the implants. Although inadequacies in the bonding effect of cement and in the structural strength of polyethylene have been cited as contributing factors in the incidence of loosening of the tibial component, this complication occurred in less than 2% of 532 cemented Anatomic Total Knee (ATK) replacements that were available for review at a follow-up period of two to 11 years. The long-term follow-up results, based on pain relief, motion, and level of activity, were judged excellent or good in 89% of the knees. Problems related to the patella and loosening of the tibial component were the predominant mechanical complications that required revision. The incidence of loosening was routinely related to technical malalignment of the knee joint or the prosthesis. However, experimental and recent clinical studies indicate that porous-surfaced implants may provide a more durable and long-lasting mode of stabilization. Except for the adaptation of the implants to the porous-coated, noncemented technique, the ATK arthroplasty ensemble has remained essentially unchanged from the original 1972 design. | |
| 6803978 | Benoxaprofen: side-effect profile in 300 patients. | 1982 May 8 | Out of 300 patients who had taken benoxaprofen for a mean of 6.4 months, 196 (65.3%) reported side effects, resulting in 104 patients (34.6%) having the drug withdrawn. Out of 42 patients aged over 70, 35 (83.3%) had side effects and 29 (69.0%) had the drug withdrawn because of them. cutaneous side effects accounted for 180 (69.5%) of all 259 side effects reported. The commonest cutaneous side effect was photosensitivity, which occurred in 86 patients (28.6%). Photosensitivity, which occurred in half of the patients treated in the summer, resulted in withdrawal of benoxaprofen in 26 (30.2%) of the patients who experienced it. Onycholysis was observed in 38 patients (12.6%) and was frequently unnoticed by patients. The overall incidence of gastric side effects was 12.6% (38 patients), and the figure rose to 40.5% (17 cases) in patients over 70. During treatment with benoxaprofen one patient developed an active duodenal ulcer but no cases of major gastrointestinal haemorrhage occurred. Multiple subepidermal cysts (milia) were observed in 16 patients, who had been treated for a mean of 10.8 months. These findings show that benoxaprofen is a potent phototoxic drug and that the manufacturers' recommended dosage of 600 mg daily is associated with an unacceptable incidence of side effects in the elderly. | |
| 42386 | Native cross-links in collagen fibrils induce resistance to human synovial collagenase. | 1979 Sep 1 | A model system consisting of highly purified lysyl oxidase and reconstituted lathyritic chick bone collagen fibrils was used to study the effect of collagen cross-linking on collagen degradation by mammalian collagenase. The results indicate that synthesis of approx. 0.1 Schiff-base cross-link per collagen molecule results in a 2--3-fold resistance to human synovial collagenase when compared with un-cross-linked controls or samples incubated in the presence of beta-aminopropionitrile to inhibit cross-linking. These results confirm previous studies utilizing artificially cross-linked collagens, or collagens isolated as insoluble material after cross-linking in vivo, and suggest that increased resistance to collagenase may be one of the earliest effects of cross-linking in vivo. The extent of intermolecular cross-linking among collagen fibrils may provide a mechanism for regulating the rate of collagen catabolism relative to synthesis in normal and pathological conditions. |