Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 555022 | [Morvan's fibrillary chorea]. | 1979 | Two cases of Morvan's chorea are reported. One of the patients presented the characteristic of having had two attacks, the first after organic mercury preparations, and the second after gold salts for inflammatory rheumatism. The second case had facial fibrillations only, and this was followed by a regressive polyradiculoneuritis one month later. This latter case raises certain diagnostic problems. The existence of a particular type of immuno-allergic tendency could be validly related to a triggering effect of various etiological agents (metals such as mercury or gold salts, or infective agents). The absence of hypotonia, and a regressive course appear to be the characteristics that distinguish fibrillary chorea from the continuous activity syndrome of the muscle fibers described by Isaacs. | |
| 422602 | The total condylar knee prosthesis. A report of two hundred and twenty cases. | 1979 Mar | The total condylar knee prosthesis is a non-hinged surface replacement which can be used for almost all knee deformities. This report discusses the first consecutive 220 arthroplasties in 183 patients. Follow-up time was three to five years. Before operation eighty-six knees had more than 10 degrees of fixed varus deformity and thirty-one knees had more than 10 degrees of fixed valgus deformity. All patients were assessed using The Hospital for Special Surgery scoring system. Of the total of 220 knees, 137 (62%) were rated excellent; sixty-one (28%), good; ten (4.5%), fair; and twelve (5.5%), poor. Of 139 osteoarthritic knees, 93% were rated excellent or good. Complications included three deep infections and four cases of posterior subluxation. The over-all reoperation rate was 3.6%. | |
| 2935924 | Pulmonary injury induced by gold salts treatment. | 1985 Oct | Pulmonary damage is one of the rare complications of gold salts therapy. The reaction is that of drug hypersensitivity. The clinical and radiological features as well as the respiratory function tests are that of an interstitial lung disease. This condition is described in four patients and its main features are discussed in the light of the relevant literature. The importance of an early diagnosis is emphasized. Most of the patients recover after the withdrawal of the drug and during corticosteroid treatment. | |
| 6983680 | [Role of bacterial polyclonal activators in autoimmunity]. | 1982 Oct 23 | Polyclonal activation of lymphocytes constitutes a non-specific stimulation resulting in the production and secretion by these cells of biologically active molecules, including antibodies. Polyclonal activation of human and animal lymphocytes can be observed, usually in vitro, with many active macromolecules of bacterial origin (surface constituants or excreted compounds). It is a complex phenomenon which may involve several cell populations (B-lymphocytes, T-lymphocytes, macrophages, etc.) and numerous mediators (lymphokines, monokines, etc.). An ever increasing collection of data suggests that polyclonal activators induce the synthesis of a variety of antibodies directed against the host (auto-antibodies). The relationship between auto-immune diseases and the presence of polyclonal activators in situ is discussed. | |
| 402750 | Influence of anti-rheumatic drugs on human lymphocytes in vitro. | 1977 Jan | Influence of anti-rheumatic drugs on human lymphocytes, especially T and B cell membranes, was studies with D-penicillamine, aurothiomalate, dexamethasone, cyclophosphamide, mitomycin C and aspirin. METHOD: Peripheral blood obtained from five healthy individuals and lymphocytes were separated by centrifugation with Lymphoprep. The separated lymphocytes were adjusted to 5 X 10(6)/ml in PBS. The suspension of lymphocytes was mixed with equal volume of each concentration of the above drugs. After suspensions, we investigated the percentages of T -and B-cells, compared to control. The results are as follows: 1. Drugs which act only on the T cell membrane: D-penicillamine, aurothiomalate. 2. Drug which acts only on B cell membrane: dexamethasone. 3. Drugs which act on both T- and B-cell membrane: mitomycin C, cyclophosphamide and aspirin. | |
| 126561 | Interaction of bacterial cell wall polymers and rat macrophages. | 1975 Jul | Processing of group A and group D streptococcal cell wall was measured after phagocytosis by normal rat peritoneal cells in tissue culture. Group A cell wall was practically non-biodegradable in contrast to group D, which was over 80% degraded by 4-8 days in culture. There was no difference in elimination or degradation of mucopeptide or polysaccharide of group A cell walls. Neither antiserum or sensitized lymphocytes affected persistence. Macrophages from Fisher rats (susceptible to group A cell wall-induced polyarthritis) became cytotoxic for target L-cells 6-7 days after ingestion of group A cell walls. Phagocytosis of group D cell walls induced less cytotoxicity. Macrophages from Buffalo rats (resistant to polyarthritis) were less cytotoxic after phagocytosis of group A cell walls than Fisher macrophages. Soluble cytotoxins could not be detected in macrophage culture media. | |
| 128270 | [Antibodies to the lipoproteinase of group A hemolytic streptococci in the blood of health | 1975 Aug | In examining 170 samples of blood sera of healthy and sick individuals it was shown that with the aid of a simple and express antilipoproteinase test it was possible not only to reveal, but also to determine the titre of specific antibodies to the lipoproteinases of various serological M-types (2, 4, 22/12, 22 and 49) of a hemolytic streptoccus, group A. The antibodies to the enzymes were frequently revealed in the sera of adults and older children. The results obtained were still inadequate for the epidemiological or clinico-immunological analysis, but pointed to the principal possibility of using the antilipoproteinase test for the mentioned purpose. | |
| 1165620 | [Granulocyte dysfunction. Part II. Secondary defects. (authors transl)]. | 1975 Aug 15 | In the first part we reviewed both the molecular basis of granulocyte function and the inborn defects. The present chapter summarizes our knowledge of the secondary defects of chemotaxis, opsonisation, phagocytosis and intracellular microbicidal activity. | |
| 7302538 | [Steroid withdrawal syndrome. A current problem of outpatient medicine]. | 1981 Oct 3 | In contrast to a widespread belief, the authors consider a single measurement of serum cortisol concentration in the early morning to be a reliable and simple outpatient screening method for detecting spontaneous or iatrogenic adrenal insufficiency. In patients on steroids the method allows detection of iatrogenic damage to the adrenals while steroid therapy is still continuing. Important guidelines for the conduct of a planned attempt to withdraw steroids can thus be obtained. Routine use of early morning cortisol measurements has greatly improved clinical knowledge about the multifaceted steroid-withdrawal syndromes (SWS). The symptoms of classical adrenal insufficiency in the form of SWS are described, as are the often atypical signs and symptoms occurring when the disease initially calling for steroid treatment is still active during attempts to lower the therapeutic dose. In addition, attention is drawn to SWS due to psychological causes. | |
| 6499377 | Simplified screening for immune complexes by laser nephelometry of ultracentrifuged serum. | 1984 | Serum samples were drawn from 14 healthy volunteers after an overnight fast and again after a meal. Each sample was divided into two aliquots. One aliquot was centrifuged at 20,000 rpm for 20 min, and a portion from the middle of the tube was removed by puncturing the tube's side. All samples were then added to cuvettes containing 0.14 M NaCl alone or 1, 2, 3, or 4% polyethylene glycol in 0.15 M KCl. The light scattering of each tube was measured. The centrifuged samples scattered 58% less light than the uncentrifuged controls. The range of values obtained with the centrifuged samples was also smaller as reflected in the standard deviation of the means obtained at each polyethylene glycol concentration. The coefficient of variation for replicate samples ranged from 0 to 16.6% (mean 5.8%), even when samples were processed differently. Storage at -70 degrees C significantly increased light scattering compared to baseline values. Serum samples were drawn from 44 patients with diseases that have been associated with immune complexes. Nephelometry selectively identified some groups of patients as abnormal. We conclude that preparative ultracentrifugation removes much of the background light scattering of serum samples, including that due to lipid, under conditions that do not sediment out immune complexes. Because it measures a physical property of immune complexes, this assay may provide information that is not available from biological receptor-based assays. | |
| 1255663 | Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent | 1976 Mar | A series of 37 1-ethyl- and 1-n-propyl-1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids bearing one, or two, substituents on the benzene ring has been synthesized via the acid-catalyzed condensation of a substituted tryptophol with ethyl propionylacetate or ethyl butyrylacetate. Antiinflammatory and ulcerogenic effects were examined and the results show that 1, 8-diethyl-1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acid (etodolic acid, USAN) is a potent agent, particularly active against a chronic rat model of inflammation (ED50 0.7 + 1-0.1 mg/kg po in the adjuvant arthritis model) and which has a relatively low acute ulcerogenic potential in the same species. | |
| 1124890 | Bacteremia related to fiberoptic bronchoscopy. A case report. | 1975 Apr | This is the first reported case of fiberoptic bronchoscopy associated with bacteremia originating in the respiratory tract. The patient had a gram-negative bacterial bronchitis before fiberoptic bronchoscopy and later died of complications of the bacteremia. | |
| 6610758 | Gold induced thrombocytopenia: platelet associated IgG and HLA typing in three patients. | 1984 Jun | Three patients who developed thrombocytopenia while taking gold therapy are reviewed. Bone marrow examinations at the time of thrombocytopenia revealed adequate numbers of megakaryocytes. Elevated levels of platelet associated IgG (PAIgG) were demonstrated in relationship to the thrombocytopenia. A response to prednisone therapy was seen with a rise in platelet count and a fall in PAIgG. All 3 patients were found to have the following alloantigens of the major histocompatibility complex, HLA-B8, DR3. These findings suggest that gold induced thrombocytopenia is immunologically mediated and possibly related to the genes of the major histocompatibility complex. | |
| 3894413 | Rheumatoid factor in syphilis. | 1985 Jul | Immunoglobulin M (IgM) antibodies directed against IgG antibodies (rheumatoid factor [RF]) are known to occur often in patients with syphilis and to interfere with serological tests measuring specific antibodies of the IgM class. In this study we examined the occurrence and specificity of the RF and demonstrated a simple method to detect and eliminate the RF for a specific Treponema pallidum IgM enzyme-linked immunosorbent assay. We measured the occurrence of the RF with a sensitive enzyme-linked immunosorbent assay and found that it increased with the duration of syphilitic disease: 1 of 13 primary syphilis serum specimens, 3 of 13 secondary syphilis serum specimens, and 10 of 27 latent syphilis serum specimens were reactive in this RF test. Those sera containing IgM RF were immunoprecipitated with anti-human gamma chain antibodies and 2% polyethylene glycol until the RF was removed. One serum specimen from a patient in the secondary stage of syphilis and eight serum specimens from patients with latent disease still presented the RF after immunoprecipitation. Removal of the IgG antibodies also improved the sensitivity of the treponemal IgM test, indicating competition of these antibodies for binding sites of the antigen. The enzyme-linked immunosorbent assays for detection of RF and antitreponemal IgM antibodies are performed on the same plate. Theoretically, only sera positive for both tests have to be immunoprecipitated. But our findings indicated an increase in sensitivity of the IgM enzyme-linked immunosorbent assay after removal of IgG antibodies responsible for competition at the binding sites. | |
| 6992269 | Effects of cryoglobulins and aggregated IGG on in vitro monocyte phagocytosis. | 1980 | Monocyte yeast cell phagocytosis (YCP) was low in presence of cryoglobulins(CG) from 7 of 7 patients with SLE and RA with vasculitis and from 2 of 5 patients with essential cryoglobulinaemia. IgM and C3 were detected only in CG associated with low YCP. Furthermore, low YCP was only found with CG isolated from hypocomplementaemic sera. The results also showed low YCP when heat-aggregated IgG (HAG) greater than or equal to 19S was added to the culture medium. In the presence of HAG or SLE-sera, preopsonized yeast cells could be adequately phagocytosed by monocytes whereas, in parallel cultures, the phagocytosis of untreated yeast cells was low. It is possible that CG and HAG impair YCP in the same way as SLE-sera. The nature of this presumed common mechanism has not been clarified in this limited study. The findings are, however, compatible with the possibility that immune complexes may interfere with the opsonization of the yeast cells, possibly through inactivation of complement components. | |
| 1173629 | Acute rheumatic fever in adults. | 1975 Jun 2 | Acute rheumatic fever (ARF) in 53 adults was characterized by a severe, febrile migratory polyarthritis involving primarily large joints in the lower extremities, with evidence of an antecedent streptococcal infection. Carditis, present in only eight (15%) of the adults, was mild and transient. The characteristic abnormality in laboratory findings was an erythrocyte sedimentation rate (Westergren) greater than 100 mm/hr. Response to high-dose aspirin therapy was prompt and dramatic in all patients. Mild andevanescent abnormalities of both renal function and hepatic function (not aspirin-mediated) were detected in 51% and 64%, respectively. A common disorder in San Antonio, ARF has distinctive symptoms. It can be readily diagnosed and promptly treated. In the adult, it is almost exclusively a syndrome of events severe but transient in the joints, and mild and transient in the heart, kidneys, and liver. | |
| 4629949 | Human anti-IgM iso-antibodies in subjects with selective IgA deficiency. | 1972 Nov | IgG-class iso-antibodies against human IgM (`reverse rheumatoid factors') were detected in titres from 1:4 to 1:1024 in the serum of twelve of forty subjects (30%) with selective IgA deficiency. The antibodies were detected in a haemagglutination system with red cells coated by the chromic chloride method with proteins from a panel including nineteen Waldenström macroglobulins. The forty subjects included seventeen normal subjects, ten with recurrent infections, seven with ataxia telangiectasia, two each with asthma and lymphoma and one each with rheumatoid arthritis and chronic active hepatitis. Four of the twelve positive sera contained `class-specific anti-IgM' which reacted with all or most of the IgM coats. The eight sera containing `anti-IgM of limited specificity' included six reacting with only one IgM coat, one reacting with two IgM coats and one reacting with four IgM coats. The anti-IgM in the latter serum defined an inherited allotypic marker on these four IgM proteins. There was no significant correlation between the presence of anti-IgM antibodies and the clinical status, sex and age of the patient nor the presence of antibodies against human IgG, human IgA and ruminant proteins. These antibodies against human IgM represent yet another immunologic abnormality in this group of patients. | |
| 310596 | Antigens in human monocytes. III. Use of monocytes in typing for HLA-D related (DR) antige | 1978 Dec | Monocyte preparations were obtained from the peripheral blood by adherence to plastic dishes. The number of monocytes obtained was significantly greater than the number of B cells recovered from similar samples. Monocytes could be frozen and thawed with relatively little loss in cell numbers or viability. Cytotoxicity tests were performed most reliably at 20 degrees C. Under these conditions, autoantibodies were rare, and normal sera were consistently negative. Serologic reactions obtained with monocytes correlated well with the known specificities of the monocyte panel. Typing results in both normal and diseased populations were similar to results obtained with B lymphocytes. Moreover monocyte cytotoxicity tests were more convenient and easier to read than similar tests performed with B cells. | |
| 398205 | Antibodies to native DNA in connective tissue disease. A comparison of radioimmunoassay, c | 1979 | Sera of patients with symptoms of connective tissue diseases were investigated for the presence of antinuclear antibodies by indirect immunofluorescence on rat liver substrate. In positive cases antibodies to native DNA were determined by radioimmunoassay and by counterimmunoelectrophoresis. Twenty seven selected sera were also tested by indirect immunofluorescence on Crithidia luciliae substrate to test the sensitivity and specificity of this method. Immunofluorescent antinuclear antibodies could be found in all groups of connective tissue diseases while anti-native DNA antibody was demonstrated in higher amount only in the cases of systemic lupus erythematosus and therefore determination of anti-native DNA antibody may be helpful in the diagnosis of oligosymptomatic SLE. Counterimmunoelectrophoresis and immunofluorescence on Crithidia smears may serve as screening methods for anti-native DNA while radioimmunoassay provides a quantitative determination, although there are minor differences in the sensitivity and the specificity of these three methods. | |
| 7257679 | [Craniovertebral deformities of an inflammatory nature, their clinical and vocational sign | 1981 | Clinical and roentgenological examinations of patients in whom an inflammatory process has spread to the craniovertebral region, as well as the outcome of local acute affections of the latter have shown that in all such cases there develop similar deformities and imbalance in that region. These pathologies are frequently accompanied with neurological disorders aggravating the disability and laying obstacles to professional rehabilitation. |