Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4821007 | Aspirin and the kidney. New Zealand Rheumatism Association Study. | 1974 Mar 30 | A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy. Analgesic nephropathy was diagnosed clinically in three patients taking APC (aspirin, phenacetin, and caffeine or codeine or both) and in one who took aspirin and phenylbutazone and was suspected in one who took aspirin and paracetamol. Isolated aspirin was not implicated. The study showed that most people can take large quantities of salicylates without renal injury.The findings are, however, consistent with the view that there is a risk from APC compounds taken in large quantity, but the numbers at risk in this study were small. Aspirin may have an additive effect with other analgesics in causing renal damage. An increased frequency of urinary tract symptoms in those taking analgesics requires further investigation. | |
| 4629907 | The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythem | 1973 Jan | Single-stranded DNA (SDNA) occurs in high incidence and in greatest concentration in the sera of patients with systemic lupus erythematosus (SLE), where levels as high as 250 mug/ml were observed. SDNA appears to be an imunogen for anti-SDNA antibodies and forms complexes in vivo of both anti-SDNA-SDNA and anti-NDNA-SDNA types, which apparently play a role in the pathogenesis of the glomerulonephritis found in patients with SLE, SDNA is also found in high incidence but at lower levels in the sera of patients with rheumatoid arthritis. Lesser amounts of SDNA are found in several other diseases in which a low incidence of anti-SDNA antibodies is observed. | |
| 6181920 | Endogenous and interferon-augmented natural killer cell activity of human peripheral blood | 1982 Jul | Peripheral blood mononuclear cells (PBMC) of normal human donors are spontaneously cytotoxic for certain tumour-derived and virus-infected target cells. This so-called natural killing (NK) can be augmented by the action of interferons (IFN) and by IFN-inducers. In this study, we have compared both endogenous and augmented NK activity of normal donors with that of patients suffering from either multiple sclerosis (MS), systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Endogenous NK was assayed using an NK susceptible target cell (K562), and augmented NK using a target cell (WI-L2) which is lysed only by NK effector cells that have been pre-stimulated by IFN or IFN-inducers. While NK function appeared normal in RA patients, this study confirms previous reports of defective endogenous NK in many MS and SLE patients. In addition, anomalous IFN-augmented NK was also detected in many patients with these two diseases, indicating that defective NK function cannot always be corrected by IFN treatment in vitro. Analysis of IFN production, endogenous NK and IFN-augmented NK by individual patients with MS or SLE showed the defects in their IFN-NK systems to be highly selective, suggesting that individual components of this system may operate independently. | |
| 1128821 | [Importance of enzymes in the synovial fluid. Progress report]. | 1975 May 16 | The significance and importance of investigation of the synovial fluid enzymes in the main arthropathies are explanined. Tables are given for the main enzymes studied, the cell compartments of origin, and data for their values in rheumatic diseases (as reported in the literature). Stress is laid on the importance of enzymes belonging to the lysosomial compartment, both in the pathogenesis of the underlying inflammation and in the relation to anatomopathological lesions in the joints. Attention is directed to the most widely accepted hypotheses. These ten to see enzymes increases in breakdown of condrocytes, as inflammatory arthritis attributable to synoviocytes and leukocytes. A personal opinion based on prior research is also presented. Further work in this sector is urged a mean of learning more about the pathology of rheumatic diseases. | |
| 815913 | Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the | 1976 Mar | Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbutazone, but not the activity of sodium salicylate or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat. The mobilization of inflammatory cells was not affected by aspirin in the presence or absence of caffeine. The mild analgesia produced by aspirin was confined to a hyperalgesic test in which this drug was able to reduce inflammation and concomitant hyperalgesia and thereby produce an "apparent" analgesic effect. This "apparent" analgesia produced by aspirin was potentiated by caffeine. The mechanism responsible for the potentiated anti-inflammatory and mild analgesic activity of aspirin remains unknown since caffeine did not alter the plasma salicylate levels or prostaglandin synthetase inhibition produced by aspirin. | |
| 805429 | Isolation of a low-molecular-weight serum component antigenically related to an amyloid fi | 1975 Apr | An amyloid fibril protein of unknown origin from a patient with systemic amyloidosis has been purified to homogeneous charge and size by gel filtration and two step isoelectric focusing. From crude antisera to the initial heterogeneous fibril protein, monospecific antibodies have been obtained by immunoabsorption with the immobilized purified amyloid protein. These antibodies have been used to identify an antigenically related serum component in whole sera of patients with and without amyloidosis. Chromatography on Sephadex G-200 in phosphate buffered saline of a patient's whole serum yields a component with an apparent molecular weight of approximately 200,000. Guanidine denaturation of this high-molecular-weight serum component followed by Sephadex G-100 column chromatography in 5 M guanidine affords an antigenically reactive protein with an apparent molecular weight of about 12,500. The antigenic similarity and molecular weight of the latter protein indicates that it could act as the smallest serum precursor of the tissue fibril protein in this group of cases of amyloidosis. | |
| 6421292 | The importance of tissue substrate in the SS-A/Ro antigen-antibody system. | 1984 Feb | Using highly monospecific anti-SS-A containing sera and specific antibody to SS-A antigen dissociated from immune precipitates, tissue sections and cell culture lines were evaluated by the indirect immunofluorescence technique to determine the intracellular location, tissue distribution, and species specificity of the SS-A/Ro antigen. The SS-A/Ro antigen is predominantly a nuclear antigen giving an immunofluorescence staining pattern of discrete nuclear speckles. The SS-A/Ro antigen is present in a wide variety of human tissue, including kidney and liver parenchymal cells, lymphocytes, fibroblasts, and epithelioid cells. However, the SS-A/Ro antigen does appear to have a variable species distribution, with significant quantities of the antigen detected by immunofluorescence in cells of human, monkey, dog, and guinea pig, but absent to low amounts detected in cells of mouse, rat, rabbit, hamster, and chicken. | |
| 6177854 | Measurement of beta-thromboglobulin connective tissue activating peptide-III platelet anti | 1982 Jan | Concentrations of the human platelet proteins beta-thromboglobulin (beta-TG) and connective tissue activating peptide (CTAP)-III were measured in synovial fluid (SF) samples by radioimmunoassay of their common beta-T/CTAP antigen. beta-T/CTAP antigen concentrations were higher in rheumatoid SF than in samples from osteoarthritis patients. When concurrent SF and plasma samples were compared, SF antigen levels were weakly correlated with plasma antigen concentrations. Incubation of fresh polymorphonuclear leukocytes with antigen in SF resulted in apparent destruction of the antigen. Our study confirms the presence of a platelet-derived growth factor antigen in the pathologic joint, and suggests that leukocytes may participate in its clearance from inflamed joints. | |
| 7115178 | Pseudorheumatoid nodule involving the orbit. | 1982 Sep | We report a clinicopathologic study of an unusual case of pseudorheumatoid nodule involving the right orbit of a child. Pathologically, the orbital lesion was similar to subcutanous nodules of rheumatoid arthritis and rheumatic fever. The physical findings and laboratory studies in our case did not reveal any evidence of systemic disease. Based on a review of reported cases involving other locations, this lesion appears clinically benign in children. | |
| 50009 | Hydralazine-induced lupus erythematosus-like syndrome. | 1975 Jul | A reversible syndrome resembling systemic lupus erythematosus and induced by hydralazine hydrochloride therapy is a well-recognized phenomenon in adults but does not seem to have been reported in children. A 9-year-old girl had fever, arthralgias, modest joint swelling, splenomegaly, antinuclear antibodies (ANAs), anitbodies against native and denatured DNA, and positive LE cell preparations after nine months of hydralazine hydrochloride therapy, 120 mg/day. Clinical findings returned to normal within four weeks of discontinuing the drug therapy, and serological abnormalities disappeared after 11 months. Like previously reported patients, the child is white and has a slow acetylation phenotype. It is not known whether children receiving hydralazine are as susceptible to this complication as adults. Periodic ANA determinations may be advisable for children receiving hydralazine, especially if they are white and have a slow acetylation phenotype. | |
| 4006385 | Urogenital involvements and rheumatic disorders in females. An interview study. | 1985 Jun | To study dependence between urogenital involvements and musculoskeletal complaints in females, 311 randomly selected women aged 15 to 54 were interviewed. In the analysis of these dependences musculoskeletal complaints were considered as a whole per person. A history of salpingitis, gonorrhoea, urinary tract infection (UTI) and Trichomonas vaginalis was revealed as constituting a relative risk factor of 4.4, 3.9, 3.1 and 4.5 respectively in connection with inflammatory rheumatic disease or suspicion of it, with or without dorsal pains of unknown cause. Anamnestic cervicitis was disclosed as constituting a relative risk factor of 1.9 in connection with joint pains in the extremities and 1.8 in connection with dorsalgia of unknown cause, but not a statistically significant relative risk of inflammatory rheumatic diseases or suspicion of them. Salpingitis is proposed as a diagnostic criterion for female Reiter's syndrome. In epidemiologic work the importance of considering the medical history of musculoskeletal complaints as a whole per person is emphasized. | |
| 792738 | [Report of a controlled clinical trial of a new synthetic drug, parsalmide, in rheumatic a | 1976 Oct 31 | The anti-inflammatory, analgesic and tranquillizing activity of a synthetic compound called parsalmide was investigated in patients suffering from inflammatory and degenerative rheumatic arthropathies. The study was carried out in 30 subjects using the controlled experiment technique according to the "between patient" pattern, attributing parsalmide and indomethacin at random to two groups. Both preparations were found to possess good anti-inflammatory and analgesic action, comparable clinically and statistically. Tolerance was very good, particularly at gastroenteric level (no side and/or undesired effects were observed) and at the level of haemopoietic, renal and hepatic function. | |
| 6294213 | Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-indu | 1983 Jan 1 | T cells of patients with rheumatoid arthritis (RA) do not control the rate of B lymphoblast transformation induced by Epstein-Barr virus (EBV) as efficiently as T cells from healthy individuals; thus, lymphoblast cell lines are established more readily in RA lymphocytes in vitro after EBV infection. In the present experiments, we have asked whether this T cell regulation can be reproduced by lymphocytes. We found that normal T cells, activated in allogeneic or autologous mixed leukocyte reactions (MLR), produce lymphokines that inhibit in vitro EBV-induced B cell proliferation. Allogeneic MLR supernatants inhibited EBV-induced DNA synthesis 62 +/- 4% (mean +/- SE) at 10 d post-infection, whereas autologous MLR supernatants suppressed it 50 +/- 3%. RA T cell supernatants produced in an allogeneic MLR suppressed as well as normal T cell supernatants (64 +/- 5% inhibition). In contrast, supernatants from RA autologous MLR had little inhibitory activity. EBV-induced DNA synthesis at 10 d was reduced only 8 +/- 3%, compared with the 50 +/- 3% suppressive activity of normal autologous MLR supernatants. The magnitude of the proliferative responses in the autologous MLR regenerating the lymphokines was similar in the normal and RA populations. After depletion of adherent cells from the RA auto-MLR stimulators, supernatant inhibitory activities increased to normal levels (from 11 +/- 6 [SE] to 52 +/- 6% [SE]). The inhibitory factor involved in the regulation of in vitro EBV infection is a protein with a molecular weight of approximately 50,000. Its activity is eliminated by hearing at 56 degrees C and by exposure to acid at pH 2. The inhibitory activity is blocked by mixing the MLR supernatants with a polyvalent antisera or monoclonal antibodies specific for human gamma interferon. Gamma interferon produced by activating T cells in allo- or auto-MLR can reproduce T cell-mediated regulation of EBV-induced B cell proliferation, and the failure of RA auto-MLR to generate that lymphokine parallels the defective T cell regulation of EBV-induced B cell proliferation characteristic of RA lymphoid cells. | |
| 20835 | [Side effects of antibiotics in rheumatic diseases]. | 1977 Sep | Complications due to antibiotic therapy in rheumatic patients subjected to season bicillin prophylaxis in Minsk within 1965--1975 and in patients with extensive collagenoses were studied. Allergic complications mainly ih the form of allergic reactions in the patients treated with bicillin-3 or picillin-5 were observed in 7.8--16.8 per cent of the patients. Within 10 years 52 cases of anaphylactic shock due to the bicillin use were recorded. Side reactions to antibiotics were observed in 16 (17.3 per cent) out of 92 patients with extensive collagenoses. For prophylaxis of the above complications it is recommended to use rational antibiotic therapy in rheumatic patients, strict registration of allergological states in the anamnesis, testing of microbial sensitivity to the antibiotics. | |
| 144509 | [Clinical trial of the new percutaneously active antirheumatic etofenamate. Summarising re | 1977 | 2-(2-Hydroxyethoxy)ethyl-N-(a,a,a-trifluoro-m-tolyl)anthranilate (etofenamate, Rheumon Gel), a percutaneously active antirheumatic containing etofenamate as active principle has been subjected to clinical studies in both hospitalized and out-patients in various types of rheumatic disease. These trials included double-blind studies against placebo gel, controlled comparative studies against two topical commercial products (ointmentI: combination of 2-hydroxyethyl salicylate and p-menthan-3-ol; ointment II: 3,5-dioxo-1,2-diphenyl-4-n-butylpyrazolidine) and open trials for efficacy and tolerance. Of the 760 patients taking part in the trials, 556 were treated with Rheumon Gel. | |
| 6332779 | Effects of piroxicam on mononuclear cells. Comparison with other antiarthritic drugs. | 1984 Jun | Piroxicam and other antiarthritic drugs were compared with respect to their effects on T-lymphocyte/monocyte/rheumatoid synovial cell interactions leading to inflammatory mediator production. Piroxicam inhibited PGE2 formation by blood mononuclear cells, but was less potent than indomethacin. Both drugs enhanced suboptimal phytohemagglutinin (PHA)-stimulated tritiated thymidine (3H-TdR) incorporation by mononuclear cells, although optimal responses were less affected. Exogenous interleukin-2 (IL-2) enhanced suboptimal but not optimal PHA responses, and the effects of the cyclo-oxygenase inhibitors were overcome by exogenous PGE2. Thus piroxicam and indomethacin prevented the inhibition by endogenous monocyte-derived PGE2 of IL-2 secretion and activity. Other antiarthritic drugs, including antimalarials, immunosuppressive agents and gold salts, inhibited PHA-induced lymphocyte proliferation regardless of the level of stimulation. Mepacrine and chloroquine were more effective in inhibiting the release of mononuclear cell factor (MCF) that stimulated PGE2 synthesis by synovial cells. Cyclosporin-A, azathioprine and 6-mercaptopurine were more potent as antiproliferative agents than as inhibitors of mediator release. Sodium aurothiomalate and aurothioglucose selectively interfered with lymphocyte-mediated amplification of MCF release, whereas auranofin inhibited spontaneous production of monocytes and the action of MCF on synovial cells. In rheumatoid synovial cells, piroxicam and indomethacin inhibited PGE2 production but not collagenase release. Suppression of MCF release could lead indirectly to reduction of IL-2 and collagenase as well as PGE2 production and consequently to more profound inhibition of immunologically-mediated inflammation. | |
| 6084866 | Reactive (secondary) amyloidosis and its pathogenesis. | 1984 | Recent advances in amyloid research have broadened our understanding of amyloidogenesis in connection with chronic inflammatory and infectious conditions. Experimental and clinical studies have clarified many of the mechanisms of induction, synthesis and regulation of the amyloid-related serum component SAA and have shed light on the enzymatic processes involved in the cleavage of SAA and degradation of fibrillar AA protein. The current pathogenetic model emphasizes the dynamic character of amyloid disease. | |
| 1173779 | [Experiences with the effect of naproxen in chronic and degenerative diseases as in overlo | 1975 Feb | At the Orthopaedic University Clinic, Homburg, a total of 127 patients was treated with d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) from June 1973 up to June 1974. The indications were chronic degenerative changes of the joints, muscles and tendons. In the first series naproxen was administered orally. In these 45 cases a very low rate of side effects was observed. Only 4 times nausea or vomiting occurred, which in one case had been caused by an overdosage. Generally tolerance was excellent and there was a very good relief of symptoms in early all patients. Particularly in those patients whose arthrotic alterations did not yet require surgical intervention the effect as to symptomatology was extremely good. In a second series initially 63 patients and, later on, another 19 patients were treated with naproxen suppositories. As before, concomitant medication was avoided. The therapeutic results were mostly very good to good, and only in a few cases no success was seen. It should be mentioned, however, that after application of the suppositories, a few patients noted a slight local burning after insertion of the suppository. Also blood in the feces and circulatory symptoms were reported. We believe that naproxen can achieve a very good improvement of subjective symptoms, particularly when combined with other therapeutic measures such as physiotherapy and intra- or periarticular injections. This drug should not only be used in the conservative treatment of degenerative joint diseases, but also -- as shown by our experience -- after palliative surgical procedures employed in the treatment of severe arthroses. Also in these cases a positive influence on the symptoms can be achieved. | |
| 6903558 | Increased biosynthesis of complement components by cultured monocytes, synovial fluid macr | 1980 Sep | Monocytes, synovial fluid (SF) and synovial membrane (SM) macrophages from patients with rheumatoid arthritis (RA) were maintained in short-term tissue culture for up to 10 days, and the synthesis of C4, C2, C3, C5, factor B(B), D, properdin (P), C3b inactivator (C3bINA) and beta 1H globulin studied. Functionally active C2, B, D, P, C3bINA and beta 1H were synthesized by the cells in each type of culture. C4, C3 and C5 could be detected, but were functionally inactive. RA monocytes synthesized more C2 than monocytes from patients with degenerative joint disease (DJD) (P < 0.001). Similar studies revealed that SF macrophages synthesized more C3 than SM macrophages (P < 0.001) which in turn produced more C2 than monocytes (P < 0.001). Other experiments showed that SF macrophages synthesized more of each component than the other cell types. SM macrophages made more C2 than B than RA and DJD monocytes, but synthesized only small quantities of P, D and beta 1H. RA monocytes synthesized more of each component than DJD monocytes. The results of these studies show that (1) in RA, complement components can be synthesized locally in the inflamed joints, and (2) local factors in the joints probably stimulate complement synthesis. | |
| 4084376 | Transoral approach for epidural craniocervical pathological processes. | 1985 | Transoral surgery for ventral craniocervical pathology is an integral part of modern neurosurgery. This approach should be considered in many more cases than in current practice. On the basis of our experiences with 15 operations in 13 patients we feel able to improve the surgical technique in some small details, as 1. the double, two flap incision of the posterior wall of the pharynx, 2. the method of "deep" resection of the odontoid in its high upward and backward position, and 3. insertion of bone grafts and chips in the cavity of tumorous vertebrae for fixation. Admittedly, these cases are not encountered every day in neurosurgical units. An exact knowledge of the anatomical, neurological, pathological, radiological and surgical details is of vital importance and constitutes the basis of this account. This method should not be confined to specialised regional neurosurgical centres, but is within the technical capacity of all trained neurosurgeons. |