Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
ID | PMID | Title | PublicationDate | abstract |
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3791870 | Muscle morphology and enzymes in proximal and distal muscle groups of lower limb from pati | 1986 Dec | Abnormal morphological and enzymatic patterns in the lateral vastus muscle have been found in women with corticosteroid treated rheumatoid arthritis. By means of biopsies from the lateral heads of right gastrocnemius muscles, the histology and enzyme activities were compared with those found in right vastus lateralis biopsies. The findings were correlated with isometric and isokinetic strength of the plantar flexors. The relative occurrence of type I fibres in the gastrocnemius muscle was 46.4 +/- 18.7 (SD) %, which is significantly higher than found in the vastus lateralis [35.7 +/- 13.3 (SD) %] (P less than 0.03). The relatively lower percentage of type II fibres in the gastrocnemius muscle was due to a relatively low percentage of type II A fibres [mean 27.9 +/- 16.4 (SD) %] (P less than 0.05). The area of type I fibres in the gastrocnemius muscle was 26.1 X 10(2) +/- 10.0 (SD) micron 2, which is 74% of the mean area for type I fibres found in the vastus lateralis (P less than 0.01). The area of type II fibres in the gastrocnemius was 14.9 X 10(2) +/- 7.1 (SD) micron 2, which is 77% of the mean area for type II fibres found in the vastus lateralis. The isokinetic muscle strength of the plantar flexors in corticosteroid treated patients with rheumatoid arthritis was reduced to less than 50% at all angular velocities when compared with healthy women. The same difference was found in the knee extensors.(ABSTRACT TRUNCATED AT 250 WORDS) | |
2573260 | [Clinical relevance of determining lymphocyte subpopulations in peripheral blood of patien | 1989 | Blood lymphocytes were determined from 21 patients with seropositive rheumatoid arthritis (RA) in a cross-sectional study with 5 monoclonal antibodies (MAb) of the BL-series. 7 patients were examined with the same MAb over a time period of 14 weeks before and after a prednisolone-pulse therapy. The cross-sectional study showed a significant higher percentage of Ia4+ T-helper/inducer-lymphocytes in RA-patients compared to control persons. The value of Ia4+ T-lymphocytes didn't correlate to the clinical activity of the RA. No significant differences were observed in the helper/suppressor T-lymphocyte ratio. The lymphocyte subpopulations were not significantly different immediately before and after a prednisolone-pulse therapy. The percentage of B-lymphocytes was significantly higher in comparison to the controls 24 h after prednisolone-pulse therapy. An immunomonitoring of the clinical activity and the therapy of RA is not possible with the used MAb. | |
1681264 | Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. | 1991 Oct 12 | Fasting is an effective treatment for rheumatoid arthritis, but most patients relapse on reintroduction of food. The effect of fasting followed by one year of a vegetarian diet was assessed in a randomised, single-blind controlled trial. 27 patients were allocated to a four-week stay at a health farm. After an initial 7-10 day subtotal fast, they were put on an individually adjusted gluten-free vegan diet for 3.5 months. The food was then gradually changed to a lactovegetarian diet for the remainder of the study. A control group of 26 patients stayed for four weeks at a convalescent home, but ate an ordinary diet throughout the whole study period. After four weeks at the health farm the diet group showed a significant improvement in number of tender joints, Ritchie's articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, white blood cell count, and a health assessment questionnaire score. In the control group, only pain score improved score. In the control group, only pain score improved significantly. The benefits in the diet group were still present after one year, and evaluation of the whole course showed significant advantages for the diet group in all measured indices. This dietary regimen seems to be a useful supplement to conventional medical treatment of rheumatoid arthritis. | |
2942687 | Acromegalic arthropathy: a reversible rheumatic disease. | 1986 Jun | Acromegalic arthropathy may be the initial manifestation of growth hormone over-production. The presence of an underlying endocrinopathy may go unrecognized for a long period of time because of the predominance of articular signs and symptoms. We describe 2 cases of acromegaly presenting with rheumatologic manifestations, the first resembling seronegative rheumatoid arthritis, the second, post traumatic low back syndrome. Unlike previous reports, both our cases showed resolution of musculoskeletal symptoms after pituitary surgery. | |
3238358 | RF-classes (IgM, IgG, IgA) in a group of highly active RA-patients in relation to disease | 1988 | Rheumatoid factors IgM, IgG and IgA were measured in a group of highly active RA-patients before and after short time treatment with steroids. After 6 months treatment with DMARD measurements were carried out again, and RF-titres correlated to disease activity. | |
3365526 | Therapeutic intervention in rheumatoid arthritis: a case-controlled comparison of seronega | 1988 Apr | The records of 684 patients with rheumatoid arthritis (RA) attending a referral centre were evaluated. All available patients (62 cases) with definite seronegative disease were matched, where possible, for sex, age and year of onset with seropositive controls (54 cases). Seronegative females were just as likely as those who were seropositive to require treatment with disease-modifying antirheumatic drugs, whereas seronegative males were significantly less likely to do so than seropositive controls. There were no major differences in outcome or drug toxicity. Orthopaedic surgery was equally common in the two groups, with a similar spectrum of procedures, but there was a trend towards more frequent upper limb large joint arthroplasty in the seronegative group, and this was particularly evident when elbow prostheses were considered. Seronegative rheumatoid disease (at least in females) may be as severe as seropositive disease in a referral-centre population and should be treated with similar vigour. | |
3617709 | [Study of the HLA system in rheumatoid arthritis]. | 1987 | A statistically significant, after correction of P value, increased incidence of the antigen HLA-DR4 chi 2 = 32.81, p less than 0.001, was established in the comparison of the antigen incidence of HLA-A, B, C and DR antigens in 59 patients with classical and positive rheumatoid arthritis and control healthy subjects. No essential difference in the distribution of DR4 was established that depended on sex, age of occurrence of the disease, presence of rheumatoid factor and the form of the disease. | |
3780475 | Effect of non-steroidal anti-inflammatory drugs on the human small intestine. | 1986 | The suggestion that the intestinal mucosa may be abnormally permeable and thus a site of antigen absorption in rheumatoid arthritis was tested by a 51Cr EDTA intestinal permeability test. Twelve patients with rheumatoid arthritis untreated by non-steroidal anti-inflammatory drugs (NSAIDs) had normal test results, while 12 NSAID-treated patients had increased intestinal permeability. Ten volunteers ingested aspirin, ibuprofen and indomethacin 8 and 1 hours before the study. The increased intestinal permeability was proportional to drug potency to inhibit cyclo-oxygenase. Intestinal permeability also increased following an indomethacin suppository, which suggests that the effect is systemically mediated. 111Indium leucocyte scintigrams and faecal collection showed no evidence of intestinal inflammation in 9 patients untreated by NSAIDs. Twenty-nine of 53 NSAID-treated patients showed abnormal localisation of 111indium in the right iliac fossa at 20 hours, and 32 of 49 patients had increased faecal excretion of 111indium. A 99mTc-porphyrin scan suggested that the main site of NSAID-induced intestinal inflammation was the small bowel. NSAIDs are thus shown to disrupt intestinal integrity and long term treatment leads to inflammation of the small intestine. | |
1824141 | [Interstitial pulmonary involvement in rheumatoid arthritis. Analysis by bronchoalveolar l | 1991 Jan | We analyzed the results of bronchoalveolar lavage (BAL) in 14 patients with Rheumatoid Arthritis. Ten patients had total cell counts above 10 x 10(6)/100 ml and or more than 10% lymphocytes in differential counts. 40% of patients with normal clinical findings on pulmonary examination and normal A-a O2 gradients had abnormal BAL findings. These findings support the theory that pulmonary fibrosis in patients with RA may start with alveolitis, probably a lymphocytic type in 60% of cases. BAL may help early diagnosis and treatment monitoring. | |
3510687 | A double-blind study of the simple analgesic nefopam in rheumatoid arthritis. | 1986 Feb | The role of pure analgesics in the management of rheumatoid arthritis (RA) remains uncertain. In a double-blind cross-over study of 27 patients, nefopam was a more effective analgesic than placebo when given as a supplement to anti-inflammatory drugs. Both early morning stiffness and grip strength were also improved, suggesting that these are associated with pain perception rather than any other aspect of inflammation. Side-effects occurred in 9 (35%) on nefopam and none on placebo. The results suggest a valuable supplementary role for analgesics such as nefopam in the treatment of RA. | |
2694394 | [Pathological changes in cartilage of the knees in rabbits immunized with Escherichia coli | 1989 Aug | Pathological changes in the articular cartilage were found in the knees of rabbits immunized with heat-killed Escherichia coli for 8-10 months at significantly higher rate (33.3%, 12 of 36 knees, p less than 0.05) than in those immunized for 1-4 months (17.6%, 6 of 34). Cartilage degeneration showed two types which were pannus invasion at the cartilage-synovial junction, and degeneration at superficial layer of the articular cartilage as seen in rheumatoid arthritis of human. Depositions of immunoglobulin were found in 10 out of 16 knees (62.5%) with the pannus invaded lesion and 5 out of 8 knees (75%) with the degenerated superficial layer of articular cartilage. | |
2980251 | The lectin binding pattern of normal and pathologically altered synovial tissue. | 1988 Oct | Light-microscopical lectin-binding studies were carried out in healthy and pathologically altered synovial tissue (osteoarthrosis, rheumatoid arthritis (RA)). Seven lectins were studied: Con A, DBA, PNA, RCA, SBA, UEA-I, and WGA. Con A and WGA mark all lining cells and the majority of subintimal synovial cells. RCA and SBA stain only a portion of lining cells, regardless of the basic pathology. The lectin PNA reacts only with RA and arthrotic material, and is thus suitable for the diagnosis of inflammatory changes in synovial tissue. UEA-1 is a consistent marker for capillary endothelium and large vessels. | |
2638659 | Necrobiotic pulmonary nodule leading to pyopneumothorax in a case of rheumatoid arthritis- | 1989 Jul | A 49-year-old male patient, an active case of sero positive rheumatoid arthritis involving multiple joints with bilateral necrobiotic pulmonary nodules is presented. Initial symptoms were of progressively increasing dyspnoea. The nodule in the right lung subsequently cavitated leading to pyopneumothorax. The diagnosis of rheumatoid lung was confirmed by post-mortem. | |
3107649 | Sodium aurothiomalate toxicity and sulphoxidation capacity in rheumatoid arthritic patient | 1987 Jun | The association between sulphoxidation capacity and sodium aurothiomalate toxicity was investigated in 65 patients undergoing treatment for rheumatoid arthritis. Of those showing side-effects, 30/37 (81%) were also poor sulphoxidizers compared with only 9/28 (32%) in the group not displaying adverse reactions. A patient with poor sulphoxidation had a nine-fold greater risk of developing toxicity. The prior measurement of sulphoxidation capacity may help to identify those patients most susceptible to the deleterious effects of this drug. | |
3811441 | [Specialized and interdisciplinary team work in rheumatology]. | 1986 Oct 1 | The large number of rheumatic diseases demands a clear differentiation between the individual forms of diseases. For this purpose are at first necessary knowledge concerning clinical criteria and in the second place knowledge about serological and radiological examinations. The serological programme shall be relevant to practice, consist of a basis diagnostics and for particular differential-diagnostic problems shall include specialized laboratory investigations. Necessary X-ray pictures must be performed with a special aim and comparison of the sides. For therapy the interdisciplinary team work, consisting in the cooperation of rheumatologists, orthopedic surgeons, specialized surgeons and physiotherapists stood the test. An important prerequisite is also the cooperation of the outpatient and inpatient rheumatological institution. For a complex rehabilitation programme apart from the physicians experienced coworkers for tasks of welfare, ergotherapy and physiotherapy are necessary. | |
2031155 | The lateral metacarpophalangeal/metatarsophalangeal squeeze: an alternative assignment cri | 1991 | We have proposed an alternate assignment criterion for rheumatoid arthritis (RA), pain on squeezing the MCP or MTP joints. The performance of this criterion has been evaluated in 90 patients with RA and in 122 patients with other rheumatological disorders (non-RA). The proportions of patients with various numbers of sites positive (from 0 to 4) were assessed according to diagnosis; most patients with RA had at least one site positive, in comparison to non-RA where most patients had no sites positive. The diagnostic performance of 2+ or 3+ sites was similar, but 3+ is probably preferable because this simultaneously indicated both symmetry and hand and foot involvement. In conclusion, the lateral MCP/MTP squeeze performs well in comparison to many other existing clinical criteria for RA and could substitute for non-independent features (e.g. swelling and arthritis). It is easier to elicit than searching for pain and/or tenderness as fewer sites have to be examined and inter-observer variation was less than with many other clinical criteria. | |
3787543 | Relationship between silicosis and rheumatoid arthritis. | 1986 Aug | The relationship between rheumatoid arthritis and silicosis was studied by means of a case-control study in South African gold miners. One hundred and fifty seven miners with rheumatoid arthritis classified as "definite" (91) or "probable" (66) were individually matched by year of birth with miners who had no evidence of rheumatoid arthritis. Unmatched analysis of the case-control status for "probable" and "definite" cases yielded an odds ratio of 2.84 (p = 0.0001). Separate analyses yielded an odds ratio of 3.79 (p = 0.0006) for "definite" cases, a non-significant odds ratio for "probable" cases, and an odds ratio of 5.00 (p = 0.0003) for the presence of rheumatoid factor. These results could not be explained on the basis of cumulative dust exposure or intensity of exposure. The rate of progression of silicosis in both the "definite" and the "probable" groups was greater than for the control patients with silicosis, as was the probability of silicosis presenting at the start with larger nodules (type r). | |
3378126 | Errors in the prediction of creatinine clearance in patients with rheumatoid arthritis. | 1988 Jun | The accuracy of two equations used to predict creatinine clearance was assessed in 27 patients with rheumatoid arthritis (RA) and 34 controls. Both equations were accurate in controls, but overestimated the clearance in RA patients. The degree of overestimation was not related to patient characteristics. Uncritical use of these equations in RA patients may lead to serious error. | |
3739661 | Shoulder surgery in rheumatoid arthritis. | 1986 Jun | Surgery was performed on 43 shoulders in 38 rheumatic patients with disabling pain. Fifteen of 22 synovectomized shoulders were available for examination an average of 2 years postoperatively. Twelve patients were satisfied with their operations and had painfree shoulders. Nine shoulders had almost normal mobility but four patients with an advanced shoulder arthropathy had gained little motion. Two patients with severe pain had been re-operated on with arthroplasty. In 15 patients with 18 shoulder replacements, the postoperative gain in motion was limited in all shoulders. Seven out of eleven shoulders had significant pain after hemi-arthroplasty, whereas five out of seven shoulders were painfree after total replacement. It seems that synovectomy can give results which are comparable with total arthroplasty if applied in early stages of rheumatoid disease. | |
3659252 | Treatment of rheumatoid arthritis with desferrioxamine. | 1986 Dec | Desferrioxamine was used to treat six patients who had rheumatoid arthritis refractory to conventional treatment, on the basis that levels of intra-articular iron would be reduced and inflammation lessened. After a period of initial intensive treatment which was limited by side effects, five patients continued on once-weekly maintenance doses. Two patients had temporary improvement in their symptoms, but relapsed in spite of continuing treatment. The remaining three patients completed six months of treatment with no improvement in their rheumatoid disease. There were no significant changes in rheumatological parameters, immunological markers of disease activity nor radiological evidence of improvement. Treatment did lead to significant falls in haemoglobin concentration (p less than 0.01), mean corpuscular volume (p less than 0.05) and serum ferritin levels (p less than 0.02). Therefore, in spite of a reduction in iron available for haem synthesis and a fall in tissue storage iron the rheumatoid inflammatory process persisted. |