Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1861020 | Proximal row carpectomy: review of rheumatoid and nonrheumatoid wrists. | 1991 May | Proximal row carpectomy was first done in 1939 and was indicated for treatment of posttraumatic problems or Kienböck's disease. Use of this procedure in patients with rheumatoid arthritis has not been reported. Our series consists of eighteen wrists, nine with rheumatoid arthritis, and nine with other various nonrheumatoid conditions. Follow-up ranged from 12 to 120 months and included x-ray films and assessment of pain, range of motion, balance, grip strength, and patient satisfaction. Our results showed only two of the eight rheumatoid wrists to be satisfactory; failure was caused by pain and imbalance. Of the nonrheumatoid wrists, six of the eight were satisfactory, although in one of the six sclerosis is developing between the capitate and radius. Proximal row carpectomy is not recommended for the rheumatoid wrist but may be useful where other pathologic conditions are involved if the remaining articular surfaces are uninvolved. | |
| 3179586 | Rheumatoid factor in rabbits with antigen-induced arthritis. | 1988 | Rheumatoid factor was assayed weekly by hemagglutination in sera from rabbits with antigen-induced arthritis and from control immunized animals receiving intra-articular injections of saline. Both groups developed rheumatoid factor. Arthritic animals, however, maintained high titers of rheumatoid factor more persistently than controls. Pre-incubation of positive sera with native or aggregated rabbit IgG was unable to inhibit agglutination, while native and aggregated human IgG were highly effective. Rheumatoid factor was unable to induce arthritis and probably does not potentiate articular tissue damage by immunocomplexes. Although production of rheumatoid factor may be a consequence of the polyclonal activation promoted by the immunization with complete Freund's adjuvant (CFA), the presence of arthritis is associated with persistence of high titers of rheumatoid factor for longer than would be expected from immunization with CFA alone. | |
| 2624842 | Scleredema of Buschke associated with rheumatoid arthritis and Sjögren's syndrome. | 1989 Oct | A case of scleredema of Buschke associated with rheumatoid arthritis and Sjögren's syndrome is described. The onset of the skin changes and rheumatoid arthritis was almost simultaneous and the sicca syndrome developed 4 years later. | |
| 1960494 | Absence of ulnar drift in a rheumatoid hand with partial amputation of the digits. | 1991 Aug | A patient suffered partial amputation of all the fingers of her left hand. One year later, she developed rheumatoid arthritis. She was subsequently spared the deformities of ulnar drift and palmar subluxation in the mutilated left hand. The possible causes of ulnar drift are discussed in relation to this patient. | |
| 3394106 | [Fibrinolytic activity of the blood and synovial fluid in patients with rheumatoid arthrit | 1988 | Indices of fibrinolytic blood and synovial fluid activity were investigated in 75 and 25 patients with proved sero-positive rheumatoid arthritis (RA) with systemic manifestations. Changes in the parameters of the fibrinolytic system in the patients suffering from RA with systemic manifestations were regarded as symptoms of the chronic intravascular coagulation syndrome. They could play a pathogenetic role in the time course and progression of rheumatoid inflammation. | |
| 3075091 | Mechanisms of persistent synovitis. | 1988 | Rheumatoid arthritis is characterised by persistent and symmetrical synovitis. In this article we propose two linked hypotheses to explain these observations. A mechanism to explain symmetry of synovitis is described whereby fine afferent nerve fibres from joints become bilaterally sensitized to movement with resultant release of neuropeptides promoting an inflammatory response. Clinical and experimental evidence is reviewed and shows that movement and resulting hypoxic reperfusion injury leads to a persistent synovitis. | |
| 3723492 | Relationship of serum IgG rheumatoid factor to IgM rheumatoid factor and disease activity | 1986 Apr | Rheumatoid factors (RF) constitute the major autoantibodies in rheumatoid arthritis (RA). RF are directed against IgG Fc, are polyclonal, and are predominantly of the IgG and IgM classes. RF may participate in both synovial and extraarticular inflammation in RA, although the precise roles of serum IgG and IgM RF are unclear. The purpose of our study was to correlate serum IgG RF with serum IgM RF levels measured by radioimmunoassay and with clinical disease activity in 42 prospectively evaluated seropositive RA patients. IgM RF correlated with IgG RF levels and articular disease activity. IgG RF correlated with IgM RF but not with articular disease activity when adjusted for IgM RF. | |
| 2528352 | Disability and depression in rheumatoid arthritis. A multi-trait, multi-method investigati | 1989 Sep | In a sample of 107 patients with classic or definite rheumatoid arthritis (RA), we examined the convergent and divergent validity of measures of disability and depression. Scores on the self-report Disability index of the Health Assessment Questionnaire were highly correlated with physical therapist and spouse ratings of disability. Although Health Assessment Questionnaire disability scores were significantly correlated with self-reported and interviewer-assessed ratings of depression, these correlations were significantly smaller. Factor analyses of the Beck Depression Inventory (BDI) and rheumatologist ratings of BDI items indicated that this measure is highly contaminated by the inclusion of items reflecting RA disease severity. A dysphoric mood subcomponent of the BDI may be a more valid measure of depression in RA populations. Although depression and disability are clearly positively correlated in RA patients, depression scales that include somatic items are likely to yield an overestimate of the association. Finally, self-reported pain intensity was more clearly related to disability and reported recent disease activity than to depression. | |
| 1895260 | Predictors of fractures in early rheumatoid arthritis. | 1991 Jun | Three hundred ninety-five patients with rheumatoid arthritis (mean age 49 years) were followed for an average of 6.7 years, and their baseline variables from the initial visit were examined for prediction of time to first fracture. Multivariate analyses identified use of corticosteroids in women and prior diagnosis of osteoporosis as important risk factors. Among patients taking 5 mg or more of prednisone, female sex strongly predicted fractures: the 5-year probability of having a fracture was 34%. Low risk groups were nonosteoporotic and consisted of men and patients taking less than 5 mg prednisone. | |
| 3359085 | The pathogenesis and treatment of rheumatoid wrist and hand deformities. | 1988 Feb | As rheumatoid arthritis progresses, pannus formation causes subchondral bone damage and later cartilage and bone destruction. Stretching of ligaments due to capsular distension causes joint instability, and infiltration. These processes are frequently responsible for deterioration in hand function. However, present surgical treatments of wrist and hand deformities allow a degree of independence. | |
| 2344208 | Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients. | 1990 May | Evidence has suggested a genetic link between the HLA-DR4 phenotype and rheumatoid arthritis (RA), particularly in its seropositive form. Such an association varies among different ethnic groups and remains controversial for seronegative patients. Data obtained for a group of 64 Chilean patients with RA (46 seropositive, 18 seronegative), as defined by the 1987 criteria of the American Rheumatism Association, and for 76 controls are reported here. The prevalence of HLA-DR4 and DR9 was significantly increased in the group of patients considered as a whole. The prevalence of HLA-DR4 was not significantly higher, however, when seronegative and seropositive patients were separately compared with controls. Also, it did not correlate with the severity of the disease within each subgroup of patients. On the other hand, HLA-DR9 showed a highly significant difference, not previously described, only for the seropositive patients in comparison with controls. The prevalence of DQ specificities showed no relevant differences among the groups. The HLA-DR4 serotype, therefore, is a weak marker for RA and does not differentiate any subgroup of patients in the Chilean group studied. This new finding, indicating an association between RA and the DR9 antigen, may be explained by the suggestion that susceptibility epitopes are shared among different DR molecules. This hypothesis might also account for the variation in the association of DR4 with RA. | |
| 2732676 | Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis suscept | 1989 Jun 1 | The association between HLA-DR4 and rheumatoid arthritis (RA) has been established in many ethnic groups. To clarify the determinant of susceptibility to RA, a polymorphic segment of the HLA-DRB gene was amplified in vitro by polymerase chain reaction and analyzed with oligonucleotide probes specific for the HLA-DR4 DNA sequences. A particular sequence encoding amino acids Gln70-Arg71-Arg72-Ala73-Ala74 showed a strong association with RA (p less than 0.005, relative risk 6.0). This amino acid sequence occurs in the DRB molecules with three RA-associated specificities, DR4/Dw14, DR4/Dw15, and DR1. DR4/Dw4, which is common in Caucasian RA patients, has a strikingly similar amino acid sequence Gln70-Lys71-Arg72-Ala73-Ala74 in terms of polarity and charge profiles. Other RA nonassociated sequences differ from this sequence by at least one amino acid substitution that causes the change of the net charge. The composition of amino acid residues at the positions 70-74 may play a crucial role in the pathogenesis of RA. | |
| 3184110 | The use of acrylic bone cement for cervical fusion in patients with rheumatoid arthritis. | 1988 Sep | We report on 14 patients with instability of the cervical spine secondary to rheumatoid arthritis treated by fusion using a combination of traditional bone grafting techniques and methylmethacrylate bone cement. Successful fusion was achieved in all cases with few complications. The high infection rate reported by other authors was avoided by reducing the bulk of the cement mass and the use of antibiotic impregnated cement. We recommend this method of fusion to all orthopaedic surgeons involved in the treatment of patients with rheumatoid arthritis. | |
| 2666657 | Axillar ultrasound of the glenohumeral joint. | 1989 May | A new ultrasonographic method for detection of intraarticular effusion in the glenohumeral joint was developed. The distance between the humerus and the joint capsule is measured at the axilla with the humerus in 90 degrees abduction. Effusion was detected by ultrasonography in 10 of 11 joints in which effusion was confirmed by intraarticular puncture. Intraarticular injection of physiological NaC1 solution could be seen as a change in the scan. The mean ultrasonographic distance between the head of humerus and the joint capsule was 2.4 mm (SD 0.5 mm) in 80 shoulder joints of 40 healthy adults. Thus, intrasynovial effusion can be suspected if the distance is 3.5 mm (mean + 2 SD) or more, or the difference between both sides is 1 mm or more. | |
| 2147715 | Sensitivity of effect variables in rheumatoid arthritis: a meta-analysis of 130 placebo co | 1990 | In a meta-analysis of placebo controlled NSAID trials, the sensitivity of the effect variables was calculated as the correlation coefficient and as the difference between drug and placebo, divided by the placebo group standard deviation. The patient's global evaluation was the most sensitive variable overall. Pain was more sensitive than Ritchie's index. Several variables may be omitted from clinical trials, especially if two active drugs are being compared. For example, the best maximum estimate for the difference in ESR between NSAIDs and placebo was 1.0 mm/hr (95% confidence interval -1.5 to 3.4 mm/hr), and for joint size 0.44% (-1.0 to 1.9%), corresponding to a quarter of a millimeter for each of the 10 joints usually measured. It is suggested to record only the patient's global evaluation, pain, and morning stiffness. | |
| 3313340 | Oral steroids in rheumatoid arthritis. Helpful but not remittive. | 1987 Oct | Although low-dose oral corticosteroid therapy cannot be considered remittive, it has earned a place in the therapeutic armamentarium for rheumatoid arthritis. Major clinical trials of a group using corticosteroid compared with a control group have not been done since the 1950s. One of these three large trials showed some slowing of the destructive joint changes of rheumatoid arthritis with use of low doses of corticosteroid. However, these agents have well-known side effects, especially when used long-term. Elderly patients or those who have features of the disease that indicate progression (eg, multiple joint involvement, elevated ESR, early evidence of erosion on x-ray films) are likely to benefit from carefully controlled doses of a corticosteroid. Because these drugs diminish bone formation and arthritis itself accelerates osteoporosis, supplemental calcium and vitamin D are useful adjuncts. A remittive agent and aspirin-like drug should be prescribed along with the corticosteroid. Abrupt withdrawal of even a very low dose of corticosteroids in rheumatoid arthritis patients causes a flare. | |
| 2357501 | The arthritis impact measurement scales: an anglicized version to assess the outcome of Br | 1990 Jun | The Arthritis Impact Measurement Scales (AIMS) is an American questionnaire designed to measure the health status of patients with arthritis. Its suitability for use with British patients with rheumatoid arthritis (RA) has been tested. A study on 30 patients high-lighted the need to anglicize the terminology and spelling. A further 30 patients found the modified questionnaire easier to complete than the original. The concurrent validity of this modified AIMS was then tested on 59 patients by comparison with two widely accepted standards. Physical function and pain scales were tested against the Stanford Health Assessment Questionnaire (HAQ). Because the HAQ has no psychological component, psychological status was compared with the Hospital Anxiety and Depression Scale (HAD). Results showed a good correlation between the scales and it is concluded that the modified version of the AIMS may be used with confidence in British patients with RA. | |
| 2213776 | Psychological screening in rheumatoid arthritis. | 1990 Aug | Our objective was to examine the utility of the Symptom Checklist-90-R (SCL-90-R) as a psychological screening instrument for patients with rheumatoid arthritis (RA). Subjects were 81 male and 3 female patients with classic or definite RA who were categorized into 3 anatomic stage groups based on roentgenograms. Erythrocyte sedimentation rates, joint counts, and the SCL-90-R were obtained on all subjects. In addition, rheumatologists were surveyed, and items were analyzed to identify potential disease related items on the SCL-90-R. Both the survey and the item analyses supported the utility of the SCL-90-R as a psychological screening instrument in a population with RA. | |
| 3358092 | [Prediction of the response to basic treatment in rheumatoid polyarthritis. Retrospective | 1988 Feb | In order to isolate prognostic factors of the response to basic treatment in the course of rheumatoid arthritis (RA), the authors are comparing, within the scope of a retrospective study of 140 patients, the initial clinical, biological and radiological characteristics of two populations of 70 "responding" and "non responding" patients at the end of a mean course of 48.8 months. As there are significantly more males in the "responding" group, two different statistical studies are conducted for male and female patients. The first stage of the analysis enables to select a certain number of average variables or of very different distribution between "responding" and "non responding". The second stage enables, with the help of these variables, to conduct an analysis of the main components: a satisfactory discrimination between "responding and non responding" may thus be obtained for male patients; this is not confirmed for female patients, probably because this population is heterogeneous. The last stage consists in a discriminating, step-by-step ascending analysis conducted on the male population; a discriminating function is then established, permitting to differentiate correctly 82 p. cent of the patients between "responding" and "non responding". Finally, a prognostic index, easier to use, is also established, using five discriminating variables for male patients, permitting to differentiate correctly 87 p. cent of the patients. | |
| 2003511 | Herpes zoster in patients with rheumatoid arthritis treated with weekly, low-dose methotre | 1991 Mar | PURPOSE: Herpes zoster occurred in nine patients with methotrexate-treated rheumatoid arthritis. We compared these patients to a large group of methotrexate-treated rheumatoid arthritis patients in order to uncover potential factors explaining the occurrence of herpes zoster. PATIENTS AND METHODS: Data from 187 patients taking methotrexate were reviewed and compared with data from another nine patients who developed herpes zoster while taking the drug for rheumatoid arthritis, all from the same university-based arthritis clinic. Literature pertinent to infection in rheumatoid arthritis patients treated with methotrexate is reviewed. RESULTS: Herpes zoster occurred in 14.5 cases per 1,000 patient-years in our methotrexate-treated rheumatoid arthritis patients, as compared with the general population incidence of 1.3 to 4.8 cases per 1,000 patient-years. The infection was unrelated to duration of methotrexate usage, prednisone treatment, or the co-existence of diabetes mellitus, but appeared to occur in patients with high titers of rheumatoid factor and an overall longer duration of rheumatoid arthritis. There were no cases of systemic dissemination or recurrence of herpes zoster despite 27.4 years cumulative follow-up on continued methotrexate therapy. CONCLUSIONS: Herpes zoster may occur more frequently in patients with rheumatoid arthritis treated with low-dose methotrexate than in the general population. Herpes zoster in rheumatoid arthritis patients treated with methotrexate appears to be self-limited, benign, and statistically related to methotrexate use in the presence of longer-term rheumatoid disease. |