Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2037861 | The Foot Function Index: a measure of foot pain and disability. | 1991 | A Foot Function Index (FFI) was developed to measure the impact of foot pathology on function in terms of pain, disability and activity restriction. The FFI is a self-administered index consisting of 23 items divided into 3 sub-scales. Both total and sub-scale scores are produced. The FFI was examined for test-retest reliability, internal consistency, and construct and criterion validity. A total of 87 patients with rheumatoid arthritis were used in the study. Test-retest reliability of the FFI total and sub-scale scores ranged from 0.87 to 0.69. Internal consistency ranged from 0.96 to 0.73. With the exception of two items, factor analysis supported the construct validity of the total index and the sub-scales. Strong correlation between the FFI total and sub-scale scores and clinical measures of foot pathology supported the criterion validity of the index. The FFI should prove useful for both clinical and research purposes. | |
| 2789210 | HLA-DQ beta 3.1 allele is a determinant of susceptibility to DR4-associated rheumatoid art | 1989 Sep | Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoid arthritis patients using monoclonal antibodies and two-dimensional electrophoresis. Most homozygous DR4 rheumatoid arthritis patients express DR beta 1 molecules associated with Dw4 or Dw14 mixed lymphocyte culture determinants. In Caucasoids, two DR4-linked DQw3-associated beta-chain alleles are defined by two-dimensional electrophoresis. These variants, designated DQ beta 3.1 and 3.2, are associated with the serologic determinants DQw7 and DQw8, respectively. A panel of 40 DR4-positive normals was also examined for nucleotide sequence polymorphisms associated with DQB3.1 and 3.2 genes using the polymerase chain reaction and specific oligonucleotide probes. At the DQ beta level the rheumatoid arthritis panel was distinguished by enrichment for the DQ beta 3.1 allele with 100% of patients positive for DQw7. Results presented here suggest that specific DQ beta alleles may modify the effect of HLA-DR4 beta 1 alleles in conferring susceptibility to rheumatoid arthritis in a phenotype-specific fashion. | |
| 1934722 | Cervical spine instability in rheumatoid patients having total hip or knee arthroplasty. | 1991 Nov | The records and roentgenographs of 113 rheumatoid patients treated by total hip or knee arthroplasty were analyzed retrospectively. The cervical spine roentgenographs were evaluated for significant atlantoaxial subluxation, atlantoaxial impaction, and subaxial subluxation. One or more of these findings were present in 69 (61%) of the patients. Thirty-five of the 69 (50%) with roentgenographically documented cervical spine instability had no signs or symptoms of instability at the time of admission for joint replacement. This high incidence of cervical spine instability in a select population of rheumatoid patients emphasizes the importance of preoperative evaluation of the cervical spine including flexion and extension lateral roentgenographs. | |
| 2142387 | [Rheumatism and acne conglobata . Apropos of a new case, in a 13-year-old boy]. | 1990 Apr | With reference to a new case of acne conglobata-associated rheumatic disease in a thirteen-year-old boy, we recall the characteristics of the main joint and/or bone manifestations that may occur during severe flares of acne conglobata, but also acne fulminans or pustulosis of the palms and soles. Joint manifestations mainly involve the large proximal joints of the limbs and consist in pain rather than in signs of inflammation. Although recurrences may develop, joint disease responds to treatment of the acne combined with a non-steroidal antiinflammatory drug. Bone involvement consists in true rheumatic osteitis with hyperostosis responsible for densification and thickening of bone, mainly in the anterior chest wall and spine. The pathogenesis and nosologic place of these bone and joint manifestations remain controversial: they do not seem to represent true reactive arthritis and, although the B27 antigen is usually lacking, they have been likened to the group of spondylarthropathies, especially in those cases with sacroiliac involvement and enthesopathy . Oddly enough, they are reminiscent of some of the side effects of etretinate, an agent prescribed in these severe forms of acne. After a national survey carried out in 1986, the acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) was suggested to designate the range of skin, bone and joint manifestations observed. | |
| 1865065 | Ankle arthrodesis by the Heiple technique in rheumatoid arthritis. | 1991 Mar | The authors report on seven rheumatoid arthritic patients that successfully sustained ankle joint arthrodesis. They incorporated a chevron fusion technique previously described. Patients were followed an average of 44 +/- 11 months. They report a satisfactory result. | |
| 2688076 | Informational indices. Validation of criteria and tests. | 1989 | The informational indices comprise sensitivity, specificity and predictive value, and they give information on the probability of rheumatic disease being present or not. It is interesting that in clinical situations where the probability of the disease is appraised by the physician before the test, the probabilities may be strongly modified after the test. For example, if one estimates the pre-test probability of ankylosing spondylitis at 50% in a given patient, the HLA B27 antigen test will modify the probability of the disease as follows: B27 positive: probability 90% B27 negative: probability 7% The second part of the study discusses modern methods for the validation of diagnostic criteria and assessment tests. Validation of the latter includes inter- and intra-observer reproducibility, coefficient of variation, discriminating power of each assessment test in a double-blind "reverse" trial, in which the difference between placebo and active drug is the known base, the value of the tests being the unknown. | |
| 2003853 | In vivo leukocyte migration in arthritis. | 1991 Mar | We quantitated in vivo migration of neutrophils into the knees of patients with rheumatoid arthritis (RA) and osteoarthritis, using 99mtechnetium-hexamethyl-propylene-amineoxime-labeled leukocytes and gamma scintigraphy. Significant neutrophil migration occurred in patients with RA irrespective of disease duration, and it was reduced by 60% following intraarticular steroid injection. The reduction in neutrophil migration correlated with reduction in pain. Leukocyte migration into osteoarthritic joints was also demonstrated, although it was much less than that seen in rheumatoid joints. No significant leukocyte migration into the joints of patients without arthritis was demonstrated. This technique appears to provide a sensitive method for quantitatively assessing the neutrophil component of inflammation in individual joints of patients with arthritis. | |
| 2777528 | Sternocostal joints. Anatomic, radiographic and pathologic features in adult cadavers. | 1989 Aug | Using radiographic-pathologic correlation, we studied the sternocostal joints derived from 27 consecutive cadavers and one additional cadaver with rheumatoid arthritis. Radiographic findings that were tabulated included joint space narrowing, sternal or costal osteophytes, articular calcification, vacuum phenomena, and the degree of ossification of the costal cartilages. The first sternocostal joint could be classified as either a synchondrosis or synostosis in every instance; however, a joint cavity lateral to the first sternocostal joint represented a normal variation and was seen radiographically in 10 specimens. The second sternocostal joint was synovial in type and intimately related to the manubriosternal joint; cavitation within this joint was present bilaterally in 36% of our specimens. Degenerative changes in the sternocostal articulations were characterized much more frequently by sternal osteophytes than by costal osteophytes or joint space narrowing. Calcification compatible with chondrocalcinosis was observed in two cadavers. Radiographic and pathologic evidence of synovial inflammation was evident in the sternocostal joints of the rheumatoid specimen. | |
| 2246557 | Identification and isolation of a phospholipase A2 activating protein in human rheumatoid | 1990 Dec | Eicosanoids are important mediators of the destructive arthropathy observed in rheumatoid arthritis. The rate-limiting step in the eicosanoid synthesis pathway is the availability of free arachidonic acid. The phospholipase enzymes release arachidonic acid from membrane phospholipids and thus play an important role in the regulation of eicosanoid production. We have previously demonstrated enhanced phospholipase A2 and C enzyme activities in cells from patients with rheumatoid arthritis and have also described a phospholipase A2 activating protein (PLAP) in mammalian cell lines. In an attempt to determine the biochemical basis of enhanced phospholipase A2 activity found in patients with inflammatory joint disease, we examined synovial fluid from patients with rheumatoid arthritis for PLAP. To determine whether PLAP was specific for rheumatoid disease, we assayed specimens from patients with other arthropathies. Histologic examination of rheumatoid joint tissue, with the use of immunohistochemical techniques, demonstrated high concentration of PLAP in monocytes, macrophages, chondrocytes, vascular smooth muscle, and endothelial cells. Human PLAP could be biochemically isolated from synovial fluid from patients with rheumatoid arthritis and was found to be similar to PLAP previously isolated from murine and bovine sources. To determine whether PLAP could directly mediate any aspect of inflammatory disease, purified PLAP was injected into rabbit knee joints. This resulted in an acute inflammatory arthritis with synovial cell proliferation and synovial fluid leukocytosis. Purified PLAP also induced eicosanoid formation both in vivo and in vitro. With enzyme-linked immunosorbent assays, we found more PLAP in synovial fluid specimens from patients with rheumatoid arthritis compared with samples from patients with other inflammatory arthropathies as well as osteoarthritis, a noninflammatory arthropathy. These data suggest that PLAP may be responsible, at least in part, for some aspects of the destructive inflammatory arthropathy that is observed in patients with rheumatoid arthritis. | |
| 3715073 | [Direct radiographic magnification of the hand: study of erosions in rheumatoid arthritis] | 1986 Apr | Plain films and direct magnification radiographs of the hands were performed in 34 patients affected by rheumatoid arthritis, using mammographic x-ray tube, achieved with 0.1 mm microfocus, and 1.85 X magnification factor. Direct magnification radiography has provided essential or useful diagnostic data in 44% of cases, particularly in recognizing early skeletal erosions. Nevertheless direct magnification radiography must be used only in those cases in which traditional mammographic techniques do not supply satisfactory results. | |
| 2868255 | Placebo-controlled, blind study of dietary manipulation therapy in rheumatoid arthritis. | 1986 Feb 1 | In a blind, placebo-controlled study of dietary manipulation therapy in outpatients with rheumatoid arthritis there was significant objective improvement during periods of dietary therapy compared with periods of placebo treatment, particularly among "good responders". Possible explanations for improvement include reduced food intolerance, reduced gastrointestinal permeability, and benefit from weight loss and from altered intake of substrates for prostaglandin production. A proportion of the improvement was due to a placebo response, but this was not sufficient to explain the whole improvement. | |
| 3608267 | Oral and sialochemical findings in patients with autoimmune rheumatic disease. | 1987 Apr | Forty-two patients with autoimmune rheumatic diseases were evaluated for oral-dental findings and a biopsy of labial minor salivary glands was obtained. Stimulated parotid salivary gland function was assessed and levels of total protein, chloride and albumin in these secretions measured. The patients were stratified into three groups according to the severity of labial gland histopathology (normal histology, 1+ and 2+). Individuals with chronic inflammatory disease of the minor salivary glands had no decrease in stimulated parotid salivary flow but were found to have a greater incidence of oral soft tissue changes commonly associated with salivary dysfunction. However, there were no statistically significant differences in total protein or chloride levels between the groups and no albumin was detected in any samples. These data suggest that stimulated parotid function may be a poor indicator of the extent of salivary involvement in individuals with autoimmune-mediated salivary gland disease. | |
| 2790922 | [Initial experience with the treatment of rheumatoid arthritis by dietary manipulation]. | 1989 Jan 27 | The purpose was to assemble experience with the treatment of rheumatoid arthritis with fish oil and to compare the results with reports from abroad. The investigated group comprised 10 women who suffered from confirmed RA. The patients were treated by nonsteroid antirheumatic drugs. During the trial processed fish oil [Martens'oil], 10 g/day was added. The tolerance of the preparation was good. The investigation period lasted three months. After one-month intervals laboratory and clinical indicators of the activity of the disease were investigated and compared with baseline values before treatment. All investigated values improved, however, only some significantly: the level of C-reactive proteon, pain on movement, the articular index, morning stiffness. The latex-fixation test was in all patients positive at the beginning and at the end of the investigation. Fish oil as a dietetic supplement of treatment with non-steroid anti-rheumatic drugs gives the patients subjective relief, the results of preliminary observations indicate the necessity of further, in particular double blind trials. | |
| 2904830 | Leucopenia in rheumatoid arthritis: relationship to gold or sulphasalazine therapy. | 1988 Dec | Leucopenia is one of the most worrying of the many toxic effects of second-line drug therapy for rheumatoid arthritis, and much time and energy is expended in screening for it. Sulphasalazine (SASP) is generally claimed to be safer than some alternative second-line drugs but the reported incidence of leucopenia has varied widely. We have examined, retrospectively, all records of blood counts before, during and after treatment in 326 SASP treated patients and in 213 on gold. Leucopenia on at least one occasion occurred in up to 10% of patients on both drugs but usually recovered spontaneously in spite of continued therapy. 'Serious' leucopenia leading directly to drug withdrawal was a rare event occurring in only one SASP patient and in two patients receiving gold treatment. Most episodes of leucopenia do not require drug withdrawal and may not be drug related. | |
| 2315607 | Type IV collagen and laminin in the synovial intimal layer: an immunohistochemical study. | 1990 | The distribution of type IV collagen and laminin in the intimal layer of rheumatoid, osteoarthritic, traumatic and normal human synovium was determined by immunohistochemistry using polyclonal and monoclonal antibodies. All samples showed a similar pattern of labelling with type IV collagen and laminin present around the synovial intimal cells. Type IV collagen has previously only been identified in association with basement membranes which are not found at this site. Two major basement membrane components around synovial cells suggest the formation of a modified basement membrane-like structure. | |
| 1707576 | Proteoglycan epitope in synovial fluid in gonarthrosis. 28 cases of tibial osteotomy studi | 1991 Apr | High tibial osteotomy was performed for medial gonarthrosis in 28 patients. Preoperatively, and at 3, 12, and 24 months after surgery, clinical and radiographic examinations were made, and joint-fluid samples were aspirated. Arthroscopy was performed preoperatively and at 24 months. Immunoassay of proteoglycan epitope in joint fluid showed an increase in concentration at all times as compared with a reference population with normal knee joints. An increase in both the concentration and the total amount of proteoglycan epitope in joint fluid was noted at 3 months postoperatively with a return to preoperative values at later times. Regrowth of fibrocartilage did not correlate with proteoglycan epitope data. | |
| 2773297 | Incidence and characterization of canine rheumatoid factor. | 1989 Jun | Rheumatoid factor (RF) was found in titers greater than 1:8 in 72.2% of cases of classical or definite canine rheumatoid arthritis (RA) and in 5.9% or normal sera. Serum fractionation and immunoabsorbant studies that much of the RF present was IgG, although activity was demonstrated in all 3 major immunoglobulin classes. Evidence of involvement of both IgG and IgM to form complexes of varying sizes was obtained. | |
| 3782247 | St Georg modular knee prosthesis. A two-and-a-half to six-year follow-up. | 1986 Nov | The St Georg modular knee replacement has been studied in 59 cases with an observation period ranging from 28 to 73 months. In 47% of the knees both compartments were replaced; five of the six poor results were in this group. These were revised to a hinge arthroplasty or, in one case, to an arthrodesis. Other complications were few and insignificant. There were no infections. We concluded that unicompartmental knee arthroplasty can be recommended when joint involvement is localised to one compartment only. With more generalised joint disease we prefer a semiconstrained total condylar prosthesis. | |
| 3686226 | Upper cervical involvement in rheumatoid arthritis. | 1987 Oct | Atlanto-axial dislocation and upward migration of the odontoid were studied in patients with rheumatoid arthritis treated conservatively and those treated by atlanto-axial posterior fusion. Upward migration of the odontoid was evaluated by Ranawat's and Redlund-Johnell's methods after determining the normal range in healthy Japanese adults. Of the 100 patients treated conservatively, atlanto-axial dislocation was found in 49% and upward migration of the odontoid in 26% by the former method, and in 8% by the latter method. The detection rate of these lesions increased with the increase in the duration of the disease and progression of rheumatoid lesions. Abnormal Ranawat values are associated with lesions in the C1-C2 segment and abnormal Redlund-Johnell values with 0-C2 lesions. The latter suggests severe conditions and seems to be a useful indicator for the diagnosis of upward migration of the odontoid in our study. Though rheumatoid lesions in the upper cervical spine mainly involved the C1-C2 level, marked deterioration of the atlanto-occipital joints was also occasionally observed. Therefore, in surgical treatment, attention should be paid also to this region. Patients with abnormal Redlund-Johnell values require spinal fixation including the occipital bone. | |
| 1832245 | [The characteristics of the course of inflammatory joint diseases in the inhabitants of an | 1991 | The course of the main chronic inflammatory diseases of the joints was analyzed with special reference to the rural region of Georgia. 30 patients with rheumatoid arthritis (RA), 13 with ankylosing spondylarthritis, and 6 with reactive arthritis are registered and followed up by the rheumatologist. It is shown that the population of the region in question is characterized by a later onset of RA, a high percentage of the seronegative variety of the disease with involvement of the hand joints, and ankylosing of the carpal joints. The males demonstrate a low activity of the process. Since RA ran a benign course, the patients were only treated with nonsteroidal anti-inflammatory agents. The RA patients preserved work fitness for a long time. Ankylosing spondylarthritis was marked by the primary injury to the spine associated with the development of ankylosis and calcification of the ligamentous apparatus without a well-defined spinal deformity. Large-scale examination of the population of the region has shown the necessity of such measures for they permit identification of new cases of the disease to carry out early adequate treatment and specialized employment of the patients. |