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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
3814965	Microwave thermography--an index of inflammatory joint disease.	1987 Feb	Microwave thermography is a technique measuring microwave emission from sites of inflammation. Microwaves have a wavelength of around 10 cm and are therefore able to penetrate clinically useful depths of up to 4 cm directly measuring tissue thermal radiation. A microwave detector was applied to the study of joint inflammation in rheumatoid arthritis and in a normal control group. Fifty-two knees were scanned using the detector and a microwave thermographic index was calculated for each knee. A strong correlation was found between the microwave thermographic index, and the clinical and laboratory parameters measured. This technique was found to be reproducible, quick, simple to use at the bedside without a controlled environment and, since it measures internally emitted radiation, is inherently safe.
2463122	Epitope specificity of antibody response against human type II collagen in the mouse susce	1988 Sep	The presence of species-specific and species-non-specific (common) epitopes has been demonstrated on type II collagen (CII) using monoclonal antibodies. In this study, we investigated the role of antibody response to some species-specific and common epitopes in mice immunized with human CII for the induction of collagen-induced arthritis (CIA). Antibody responses to species-specific epitopes in arthritic mice appeared significantly higher than that in non-arthritic mice. However, no significant difference of antibody responses to common epitopes was found between arthritic and non-arthritic mice. Monoclonal antibody reactive with one of the common epitopes exhibited the ability to induce arthritis in mice previously given the primary injection of CII, indicating the involvement of this epitope in the induction of CIA. Finally, we investigated the epitope specificity of anti-human CII antibody present in serum samples of patients with rheumatoid arthritis and relapsing polychondritis, and found antibodies to some common epitopes.
3361317	Patellofemoral functional results and complications with the posterior stabilized total co	1988	The authors reviewed 73 knee arthoplasties performed with the Posterior Stabilized Total Condylar prosthesis, with an average follow-up period of 5.5 years. The function of the patellofemoral articulation was specifically analyzed. Patients with documented or suspected tibiofemoral problems were excluded. Using the Hospital for Special Surgery knee rating system, 48 knees (66%) had excellent, 20 had good (27%), and 5 (7%) had fair results. Patients with unilateral disease were able to negotiate stairs and transfer normally in 64% and 100% of the cases, respectively. The most frequent patellofemoral problem was impingement (21%), but reoperation was needed in only one patient. Stress fracture of the patella and subluxation were rare. A medial tilt of the patella on the axial view had no apparent ill effect. The patella was lowered 12 mm on average as a consequence of the standard bone resection sequence and insertion of the tibial component. The patella was significantly lower in patients with impingement than in normal joints. Routine complete patellofemoral resurfacing is advised in total knee joint arthroplasty. Complications are infrequent with appropriate prosthetic design and due technical care.
2339546	[Hemosorption combined with plasmapheresis in rheumatoid arthritis patients].	1990 Feb	The complex of treatment measures in 36 patients suffering of rheumatoid arthritis included hemosorption in association with plasmapheresis. It was established that treatment of rheumatoid arthritis using this method was followed by a positive dynamics of the articular syndrome, reduction of indices of activity of the inflammatory process.
2676268	The contribution of HLA to rheumatoid arthritis.	1989 Sep	The contribution of genes within the major histocompatibility complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital- and population-based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype-sharing studies. Using either source of information gives the same result, a contribution of 37%.
2047594	Canine distemper viral antigens and antibodies in dogs with rheumatoid arthritis.	1991 Jan	Dogs with canine rheumatoid arthritis had significantly elevated levels of antibodies to canine distemper virus. This increase was particularly seen in the synovial fluids, compared with paired sera, and was not found in dogs with infective arthropathies, osteoarthritis or in osteoarthritis secondary to rupture of the cranial cruciate ligament. Analysis of the immune complexes precipitated from synovial fluids showed immunoglobulins in all types of arthropathy. Western blotting analyses showed reactivity with anti-distemper antisera in immune complexes from dogs with rheumatoid arthritis, but not in immune complexes from dogs with other joint diseases. These results suggest that there are increased immune responses to distemper in canine arthritis and that these may be due to the presence of this paramyxovirus in affected joints. The implications for the role of a possible infectious agent in rheumatoid arthritis in the dog are considerable.
2396863	Liver histology in patients receiving low dose pulse methotrexate for the treatment of rhe	1990 Aug	The liver histology of 52 patients treated with intermittent low dose pulse methotrexate for rheumatoid arthritis was evaluated using a modification of the Roenigk grading system. Patients studied had had an average of 3.2 years of treatment or had received 1.7 g methotrexate. No patient had cirrhosis; 15 (29%) patients had evidence of mild fibrosis. Histological abnormalities were not predicted by liver function test changes, with the exception that hypoalbuminaemia occurred in 60% of those with grade IV (modified criteria) findings. The need for liver biopsy in patients with rheumatoid arthritis treated with methotrexate before two years or 1500 mg of treatment has not been established. Whether serial liver biopsies will be needed beyond this time has yet to be determined.
1891556	Daily stressors and systemic lupus erythematosus: a longitudinal analysis--first findings.	1991	Patients with systemic lupus erythematosus (SLE) and a comparison group of patients with rheumatoid arthritis (RA) completed the Dutch Everyday Problem Checklist and the Dutch Arthritis Impact Measurement Scale measuring physical and psychosocial aspects of illness. Both scales were completed 9 times at 6-week intervals. In addition several hematological and serological parameters were assayed. Analysis over several time points resulted in only weak correlations between the variables under study. The most remarkable finding of this study was that in SLE patients number and intensity of daily stressors are more strongly related to physical and psychosocial status than in RA patients.
2622275	[Sicca syndrome caused by large granulated lymphocytes in rheumatoid arthritis].	1989 Dec 9	The proliferation of large granulated T lymphocytes (LGL) with neutropenia and splenomegaly can be observed in patients with rheumatoid arthritis (RA), in a similar way to Felty's syndrome. We report a female with long standing AR, xerophthalmia, xerostomia, neutropenia and LGL lymphocytosis. The phenotype of the latter was CD3+, CD8+, HNK1+. She was treated with methotrexate and corticosteroids. The genetic rearrangement study did not show monoclonality. Although LGL lymphocytosis can infiltrate several organs, salivary glands infiltration has not been reported. The development of a sicca syndrome can be a feature of LGL lymphocytosis and induce diagnostic mistakes in RA.
2691684	A controlled study of primary fibromyalgia syndrome: clinical features and association wit	1989 Nov	One hundred and thirteen patients with primary fibromyalgia syndrome, 77 with rheumatoid arthritis (RA) and 67 healthy controls without significant aches or pains were studied by protocol to determine clinical features of primary fibromyalgia syndrome and to assess the possible association of primary fibromyalgia syndrome with common functional disorders compared with the control groups. Previously reported common features of primary fibromyalgia syndrome are confirmed in this controlled study. In addition the extent of cutaneous hyperemia on palpation was found to be greater in patients with primary fibromyalgia syndrome than in normal controls. All the 3 functional syndromes evaluated, e.g., irritable bowel, chronic functional headache and primary dysmenorrhea, were significantly (p less than 0.005) more common in primary fibromyalgia syndrome, compared with RA and normal control groups. These data suggest that primary fibromyalgia syndrome is a characteristic clinical condition that overlaps with other well recognized functional syndromes.
3258503	Bone resorbing activity in synovial fluids in destructive osteoarthritis and rheumatoid ar	1988 Mar	The synovial fluids of patients with a destructive form of osteoarthritis (DOA) were shown to contain high levels of bone resorbing activity as judged by the ability of the fluid to stimulate the release of 45Ca from labelled cultured mouse calvariae. The activity was lost on extended storage of the synovial fluids and was dependent for its effect on cellular activity in bone. Bone resorbing activity was present in most synovial fluids from patients with DOA and rheumatoid arthritis (RA) but occurred at higher levels in the former. In contrast, interleukin 1 (IL1) activity, measured by the mouse thymocytes costimulation assay, was higher in RA than DOA synovial fluids. Little or no bone resorbing or IL1 activity was detected in synovial fluids from patients with pseudogout or non-destructive osteoarthritis. These results suggest that most DOA synovial fluids contain a bone resorbing factor other than IL1. It is considered that the factor may be produced by synovial cells stimulated by hydroxyapatite crystals.
2877858	Sulphasalazine in the long term management of rheumatoid arthritis.	1986	The clinical outcome of rheumatoid arthritis patients treated long term with sulphasalazine or parenteral gold was studied. The rate of withdrawal from gold because of inefficacy was less frequent than that for patients receiving sulphasalazine. However, patients on sulphasalazine withdrew less frequently because of adverse reactions.
2009652	Long-term follow-up of cemented total hip arthroplasty in rheumatoid arthritis.	1991 Apr	Seventy-five primary cemented total hip arthroplasties (THAs) were performed in 53 patients with rheumatoid arthritis and juvenile rheumatoid arthritis. All patients were followed for an average of 7.4 years, unless their prosthetic hips failed before that time. Clinical evaluation was based on a 10-point maximum rating scale, and ratings for pain, walking, function, and activity improved from preoperative values to the most recent follow-up examination. Revision THA was performed for aseptic acetabular loosening in four hips, and femoral loosening in one hip. Sepsis occurred in another four hips. Complications of wound healing occurred in 14 hips. Roentgenographic evidence of loosening was seen in six acetabular components, in three femoral components, and in the femoral and acetabular component of one hip; none of these hips have as yet required revision THA. The Kaplan-Meier survivorship analysis revealed a 93% survival probability at seven years, which fell to 77% at 12 years in these patients. A trend was that younger, larger patients had increased failure and component loosening rates. Cemented primary THA has been a satisfactory operation in the rheumatoid patient. The relatively high rate of wound healing problems and sepsis may be due to the systemic immune nature of rheumatoid arthritis; however, 25% of these prosthetic hips either failed or are at risk for future failure. Thus, improved techniques are still necessary to increase the long-term success of THA in the rheumatoid patient.
3261537	Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid art	1988 Feb	Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.
3118443	Results of a phase-II clinical trial on treatment of rheumatoid arthritis with recombinant	1987	In an open, non-randomized clinical trial conducted at multiple centres, 49 patients with rheumatoid arthritis were treated with recombinant interferon-gamma for 20 days. The study was carried out in two sub-studies. In the first, the total daily dose of interferon-gamma was 50 micrograms; in the second, 100 micrograms. Of the 49 cases, 40 were evaluable for statistical analysis; 24 of these patients (60%) responded to therapy, according to the criteria of a successful outcome laid down in the study protocol, and were classified as responders. In responders, the clinical parameters investigated improved with both dosages. The lower dosage differed from the higher one in having a markedly lower incidence of side-effects. The results lead to the conclusion that a randomized double-blind phase-III clinical trial should be performed.
2688073	Benign polyarthritis and undifferentiated arthritis an epidemiological terra incognita.	1989	Introduction of new diagnostic criteria and the development of HLA-typing and microbiological--serological techniques have aided in classifying and differentiating inflammatory rheumatic diseases. Reviewing epidemiological prevalence studies shows that inflammatory rheumatic diseases are often so called benign polyarthritides and that arthritides, classified as definite and probable rheumatoid arthritis (RA), may belong to a group of benign or undifferentiated arthritides. Own data show that only 25% of patients of an early synovitis out-patient clinic have definite or probable RA, 25% have an undifferentiated arthritis. The term "undifferentiated" refers to the heterogeneity of diseases included. We conclude that few epidemiologic studies exist concerning undifferentiated arthritis and spondarthritis and combined efforts are needed to distinguish RA from the multitude of other well characterized or yet unknown arthritides.
2196059	Histologic and electron microscopic characterization of the antiperinuclear factor antigen	1990 Jul	The presence of the antiperinuclear factor, an autoantibody that recognizes cytoplasmic antigens, was detected in sera from patients with rheumatoid arthritis (59%), seronegative rheumatoid arthritis (36%), systemic lupus erythematosus (46%), systemic sclerosis (26%), and in nonautoimmune controls (10%). The antigenic perinuclear granules were found in the stratum intermedium layer of the buccal mucosa. Granules exhibited histologic features of nucleoproteins, stained for ribonucleoprotein, and showed the ultrastructural characteristics of aggregated rough endoplasmic reticulum. The antiperinuclear factor may recognize a common autoantigen in connective tissue disease.
3054093	In vivo effects of antirheumatic drugs on neutral collagenolytic proteases in human rheuma	1988 Aug	The destruction of joints in rheumatoid arthritis (RA) is thought to be related in part to an increased synthesis of proteolytic enzymes. We have determined neutral collagenolytic protease activity levels in human RA synovia and articular cartilage and examined the in vivo effects of various therapeutic regimens on enzyme levels. Neutral metallocollagenolytic enzyme (NMCE) was measured in 29 RA cartilages and synovial membranes. In addition, synovial serine protease levels were determined. Specimens were divided into 4 groups according to prescribed medications: (1) nonsteroidal antiinflammatory drugs alone; (2) steroids alone; (3) steroids and gold; and (4) steroids and methotrexate (MTX). Ten normal specimens were used as controls. Total and active NMCE measured in both RA cartilage and synovial membrane specimens showed a significantly higher level of activity than in controls (p less than 0.0001, p less than 0.005; p less than 0.004, p less than 0.02). MTX was found to markedly decrease NMCE activity; cartilage NMCE level in patients with RA receiving MTX was reduced, compared to the other subgroups. This was particularly noted for the active form. Synovial NMCE levels from the MTX subgroup for both enzyme forms were much lower than in any other RA subgroup, significantly lower than in the RA group as a whole (p less than 0.05), and similar to controls. RA synovial membrane serine protease activity showed an increase compared to controls. Again, MTX markedly decreased the activity of this class of enzyme. Our data strongly support the role of neutral proteases in the destruction of RA joints. MTX was the only drug to consistently decrease these enzyme levels in joint tissues.
2784966	Very late activation antigen on synovial fluid T cells from patients with rheumatoid arthr	1989 Apr	We used flow cytometry and immunoprecipitation techniques to study the expression of the activation molecules transferrin receptor, interleukin-2 receptor, HLA-DR, and very late activation antigen 1 (VLA-1) on purified T lymphocytes from peripheral blood and synovial fluid of 9 patients with rheumatoid arthritis and 7 patients with other rheumatic diseases. We found a T cell subset bearing VLA-1 in synovial fluid from 8 rheumatoid arthritis patients and 4 patients with other rheumatic diseases. VLA-1 was not found in peripheral blood T lymphocytes from either group.
2706056	Resection of the patellar ligament: a complication of arthroscopic synovectomy.	1989	Knee arthroscopy has evolved over the years to a point where most orthopaedic surgeons feel comfortable with both diagnostic and operative arthroscopy. As a result of the more powerful and sophisticated instrumentation available today, the role of operative arthroscopy has far surpassed original expectations. Certain instrumentation carries with it increased risk of both intraarticular and extraarticular injury if the surgeon fails to pay attention to anatomic landmarks. In this communication, we report a previously undescribed complication of operative arthroscopy--resection of the patellar ligament.