Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2971810 | Chronic back pain and rheumatoid arthritis: predicting pain and disability from cognitive | 1988 Jun | Cognitive-behavioral models of chronic pain emphasize the importance of situation specific as well as more general cognitive variables as mediators of emotional and behavioral reactions to nociceptive sensations and physical impairment. The relationship of situation-specific pain-related self-statements, convictions of personal control, pain severity, and disability levels was assessed in samples of chronic back pain and rheumatoid arthritis patients. Both the more general and the situation-specific sets of cognitive variables were more highly related to pain and disability than disease-related variables. This association was found in the back pain patients who displayed only marginal levels of organic findings as well as the rheumatoid arthritis sample who had a documented basis for their pain. The combination of both situation-specific and general cognitive variables explained between 32 and 60% of the variance in pain and disability, respectively. The addition of disease-related variables improved the predictions only marginally. These results lend support to the importance of cognitive factors in chronic pain syndromes. | |
| 1882189 | Presence of NAP-1/IL-8 in synovial fluids indicates a possible pathogenic role in rheumato | 1991 Sep | The synovial fluid in affected joints of rheumatoid arthritis (RA) patients contains many cells, in numbers strongly correlated with the severity of disease. As the disease worsens and the cell count increases, the polymorphonuclear leucocyte becomes the predominant cell type. Although the inflammatory cytokines interleukin 1 (IL-1) and tumour necrosis factor (TNF) have no direct neutrophil-attractant activity, they are both potent inducers of interleukin 8 (IL-8) in a variety of cell types. Chemotactic attraction of neutrophils is a major activity of IL-8. Examination of a number of synovial fluids showed that significant levels of IL-8 are present in a high proportion of RA cases (10 out of 17), at concentrations directly related to the number of cells in the joint, and to circulating C-reactive protein (CRP) levels. The cytokine is present only at background levels in other diseases accompanied by arthritic manifestations, including systemic lupus erythematosus (SLE) and induced arthritis. The progressive joint destruction seen in all cases where high IL-8 levels were measured, coupled with the neutrophil-rich cell count and the strong correlation between concentration of IL-8 and both serum CRP and cellular influx into the joint, is strongly suggestive of a pathogenic role for IL-8 in RA. | |
| 2245529 | Cytokines and anticytokines. | 1990 Jul | The inflammation in the rheumatoid synovial membrane may be characterised by the concomitant presence of proinflammatory and anti-inflammatory mechanisms and mediators. These events may be spacially distributed within the tissue and may be visualised as waves of inflammation followed by waves of repair. The aim of therapy must be to enhance the anti-cytokine and reoperative processes over the inflammatory ones. | |
| 1650959 | Diclofenac inhibits monocyte superoxide production ex vivo in rheumatoid arthritis. | 1991 | Effects of the nonsteroidal anti-inflammatory drug, diclofenac, on stimulated monocyte superoxide production were assessed directly in vitro and following treatment of patients with rheumatoid arthritis ex vivo. Diclofenac inhibited superoxide generation provoked by serum treated zymosan (STZ) and fluoride anion (F) but not by phorbol myristate acetate (PMA) in vitro. Following patient therapy, inhibition of superoxide production occurred when STZ and PMA, but not F were used as stimuli. No changes were seen in control subjects. The contrasting profiles of inhibition seen in vitro and ex vivo suggest an indirect effect on superoxide production during clinical use of the agent. These data are consistent with the hypothesis that anti-inflammatory drugs may act in rheumatoid arthritis by inhibiting phagocyte superoxide anion production. | |
| 1947893 | Relationship between procollagen III peptide serum levels, synovitis of weight bearing joi | 1991 | We studied P-III-P levels along with several acute phase reactants, Beta-2-microglobulin and autoantibody synthesis in 52 rheumatoid patients. No relationship arose between P-III-P levels and immunological parameters nor with acute phase reactants. We observed a highly significant difference between P-III-P levels in patients with knee and/or hip involvement with respect to those with only polyarthritis of small joints (86.1 +/- 21.5 vs 61.2 +/- 19.1 ng/ml; p less than 0.001). In 24 consecutive patients we also observed a significant correlation (p less than 0.02) between P-III-P levels and AIMS score. We conclude that P-III-P levels are mainly related to the synovial inflammation of major joints and as such P-III-P might represent the biochemical marker of the synovial mass in rheumatoid arthritis. | |
| 3492038 | HLA-D antigens in rheumatoid arthritis and toxicity to gold and penicillamine. | 1986 | The frequencies of HLA-D antigens were investigated in 77 Finnish patients who met the ARA criteria of classical or definite rheumatoid arthritis. The control material consisted of healthy blood donors. HLA-Dw4 was significantly (p less than 0.01) increased and HLA-Dw2 significantly (p less than 0.01) decreased in the patients. All HLA-Dw4-positive patients belonged to the seropositive group and in comparison with controls HLA-Dw4 antigen was increased highly significantly (p less than 0.001) in the seropositive patients. With respect to HLA-Dw4 antigen, the seropositive and the seronegative group differed significantly (p less than 0.05). All patients had received penicillamine treatment and 75 of them gold treatment before penicillamine. No significant associations were noted between any HLA-D antigen and gold or penicillamine toxicity. The previous gold toxicity seemed to be a significant factor with respect to the subsequent penicillamine toxicity. | |
| 2230341 | Rheumatoid factor among several cases of visceral leishmaniasis. | 1990 Dec | Rheumatoid arthritis is not an uncommon disease in Egypt. Its aetiology is still unknown. In this paper, 3 out of 7 visceral leishmaniasis cases and 1 out of 7 controls gave positive rheumatoid factor. It was suggested that L. donovani infection plays a role in the aetiology of rheumatoid arthritis. | |
| 3599414 | Cardiac tamponade in rheumatoid arthritis. Successful treatment with intrapericardial ster | 1987 Mar | Cardiac tamponade complicated by classic rheumatoid arthritis was markedly alleviated by pericardiocentesis and intrapericardial administration of steroid. For the following 2 years, no recurrence of cardiac tamponade or constrictive pericarditis was observed. According to the literature, only one other patient with cardiac tamponade complicating rheumatoid arthritis (RA) had been successfully treated patient by intrapericardial steroid administration. | |
| 1671839 | Restricted expression of T cell receptor V beta but not V alpha genes in rheumatoid arthri | 1991 Feb | Synovial fluids of patients with rheumatoid arthritis contain activated T lymphocytes that may play an important role in the pathogenesis of the disease. Previous studies have suggested that the T cell receptor (TcR) repertoire of these cells is restricted, reflecting in vivo selection of a limited number of T cell specificities at the site of inflammation. To characterize better these T cell populations we used the polymerase chain reaction technology to estimate the proportion of TcR alpha and beta RNA containing any particular V elements from transcripts directly isolated from the synovial fluid cells and from peripheral blood mononuclear cells of three patients with rheumatoid arthritis. Our data show that, in contrast to peripheral blood mononuclear cells, synovial fluid T cells expressed only few V beta transcripts, one of which was overrepresented in two patients. Peripheral and joint fluid T cells, on the other hand, appeared to express the same set of non-restricted V alpha elements. These results suggest that a major antigen associated with the pathogenesis of rheumatoid arthritis may interact selectively with the V beta component of the TcR. | |
| 2773566 | [Yersinia arthritis in children]. | 1989 | Clinical and laboratory evaluation of arthritis in 36 children with diagnosed enteric yersiniosis is presented on seven-years' follow-up data. Twenty-eight patients were found to have an active course of the disease developing in cycles with a favourable outcome and no residual effects. In eight cases arthritis took a protracted (up to 8-10 months) or chronic (over 12 months) course which ended in clinical and laboratory remission; in three of the eight cases the clinical picture was similar to that of rheumatoid arthritis, in two of which the diagnosis was not excluded by the morphological study of the synovial biopsy sample. | |
| 2066942 | Inability to interpret toxic salicylate levels in patients taking aspirin and diflunisal. | 1991 Apr | Diflunisal, a nonsteroidal antiinflammatory drug, is not metabolized to the free salicylate moiety, but yields serum salicylate levels. We describe 2 patients who unexpectedly had toxic range serum salicylate levels while taking diflunisal and aspirin for rheumatoid arthritis. Diflunisal is measured by standard salicylate assays, a fact not widely appreciated. Serum salicylate levels by these assays cannot be used to determine salicylate toxicity when a patient is taking both aspirin and diflunisal. High pressure liquid chromatography can be used to distinguish true salicylate toxicity from interference with diflunisal. | |
| 1821615 | Relationship between antinuclear antibodies and differential cell counts in synovial fluid | 1991 | Presence and titres of organ non-specific and granulocyte-specific antinuclear antibodies (ON-ANA and GS-ANA) were studied in 100 samples of synovial fluids taken from 95 patients with seropositive rheumatoid arthritis and in corresponding sera. At the same time the white cell count as well as the percentage of granulocytes and granulocytes with pycnotic or fragmented nuclei (PGS and FGS, respectively) were evaluated in the synovial fluid sediment. Twenty six percent of synovial fluid samples were positive for ON-ANA and the same percentage of samples were positive for GS-ANA. Titres of GS-ANA showed a clear inverse correlation with the number of granulocytes. The rate of PGS as well as of FGS increased with the titer of both types of studied ANA, however, a significant correlation was observed only between the percentage of these cells and GS-ANA. Differences in specificity and titres of ANA were demonstrated in samples of synovial fluids taken at the same time from both knee joints of 5 patients under study. The differences were also noticed when the specificity and titer of ANA present in synovial fluid and serum samples were compared. A case of rheumatoid arthritis showing sudden appearance of numerous plasma cells in the synovial fluid in course of the disease is presented. This patient initially had no ANA in the synovial fluid or in serum, but ANA were detected at the time of synovial fluid plasmacytosis. These data indicate that a local production of ANA is likely to take place in ANA positive rheumatoid arthritis. | |
| 3576139 | The effect of water exercise therapy given to patients with rheumatoid arthritis. | 1987 | It is well known that patients suffering from rheumatoid arthritis have a reduced muscular function. The positive effect of physical training on rheumatic patients has been shown. In this study the effect of exercise therapy performed in a heated swimming pool has been evaluated for eight patients in a non-acute stage of rheumatoid arthritis. The median pre-treatment maximal isometric and isokinetic quadriceps strength was 88 Nm (44-146) and 99 Nm (62-149) respectively, which was 61% and 70% of that found in a control group of healthy persons. After 2 months exercise therapy the median maximal isometric and isokinetic quadriceps strength increased by 38% and 16% compared to the pre-treatment value (p less than 0.02 and p less than 0.05). All patients, except one who developed cardiac arrhythmia during the second test, accomplished a submaximal bicycle test (a.m. Astrand). An increase in the aerobic capacity was observed in all patients after the training period. | |
| 1800046 | Surgical synovectomy in the treatment of rheumatoid arthritis: the results obtained in a c | 1991 Oct | The authors report the long-term results obtained after 2 and 4 years in a controlled study conducted on surgical synovectomies performed in articular and extra-articular regions in rheumatoid arthritis. Out of a total of 157 patients submitted to surgery between 1977 and 1987 admitted to the study were 82 patients with bilateral symmetric localizations, but who had been submitted to synovectomy only unilaterally. The collection and interpretation of data showed that synovectomy is truly effective and that clinical improvements is not related to a spontaneous regression in the rheumatoid process. Surgery must be performed when the degree of osteocartilaginous deficit is absent or moderate. It does not avoid local recurrence, but it does obtain an antalgic effect, better joint excursion, and a slowing down in the destructive osteocartilaginous processes. | |
| 3288293 | The effect of indomethacin on the psychomotor function of patients with rheumatic diseases | 1988 Jun | We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin. | |
| 2037249 | [Genetic determination of rheumatoid arthritis]. | 1991 Jan | The study on the nature of genetic determination of the definite rheumatoid arthritis (RA) and its forms was carried out, based on the material comprising clinical data on 189 probands and their 1st and 2nd degree relatives (713 subjects) which is contained in the computer Family Data Bank at the Department of Epidemiology and Genetics of this institute. The heritability coefficient "in narrow sense" (80%) obtained within the framework of the multifactorial threshold model confirmed once more important role of genetic factors in the appearance of the disease. The study of genetic heterogeneity within the framework of the Ch. Smith's and T. Reich's models failed to reveal any independent genetically RA forms. An assumption of the essential role of the genes localized in the X chromosome, based on diverse susceptibility of sexes, received no conformation. It has been shown that the RA distribution in the population and families may well be described by means of a variant of the single autosomal two-allele locus model with incomplete and differentiated for two sexes penetrance. The model parameters obtained, a particular penetrance of the mutant homozygote in both sexes equalling 100%, and penetrance of the normal homozygote equalling 0 in men and reaching 0 (0.028%) in women testify to a very essential influence of the major gene on determination of RA. | |
| 3517926 | The effect of increasing fibrinolysis in patients with rheumatoid arthritis: a double blin | 1986 Jan | Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease. It has been shown that in severe rheumatoid arthritis fibrinolysis is decreased but can be stimulated using the fibrinolytic enhancing agent stanozolol. A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent. Forty patients were enrolled. Twenty patients received stanozolol 5 mg twice daily for six months and 20 received a matching placebo. Assessment of disease activity was made in the conventional way. Results show that the two groups were comparable. After six months nine of the control patients had withdrawn because of drug ineffectiveness compared with two stanozolol patients, and five control patients felt they had improved compared with 15 stanozolol patients. Disease activity had significantly decreased by the end of the study in the treated group, and detailed analysis showed improvement in ESR, articular index, duration of morning stiffness and visual analogue pain scale. We suggest that stanozolol may be of value in rheumatoid arthritis although this pilot study has looked at only small numbers of patients over a short period. | |
| 2322023 | Association between HLA-DR antigens and rheumatoid arthritis in Arabs. | 1990 Mar | Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheumatoid arthritis could not be confirmed in the Arab patients resident in Kuwait, supporting reported observations in different ethnic groups of associations with HLA antigens other than HLA-DR4 and indicating a heterogeneous genetic susceptibility to rheumatoid arthritis. | |
| 2661574 | Flexor tendon ruptures in rheumatoid arthritis. | 1989 May | Flexor tendon ruptures in rheumatoid arthritis are caused by either attrition on bone spurs or by direct invasion of the tendon by hypertrophic tenosynovium. All attrition ruptures occur within the carpal canal and represent the most common cause of tendon rupture. Removal of the causative bone spur is imperative in the treatment of this condition. Ruptures due to invasive tenosynovitis also are frequently found within the carpal canal. These ruptures may be unanticipated, and may be discovered as an incidental finding during flexor tenosynovectomy. Ruptures due to invasive tenosynovitis within the digit carry an unfavorable prognosis. The prognosis for restoring flexion in the event of a flexor tendon rupture is determined by the location of the rupture, the etiology, the degree of articular involvement from the rheumatoid disease, and to a lesser extent, by the number of ruptured tendons. In general, isolated or double ruptures within the carpal canal due to attrition have a better prognosis than those caused by invasive tenosynovitis since the condition of the tendons is more favorable for reconstruction; however, as the number of ruptures increases, the prognosis in both conditions worsens. Rupture of both tendons within the digital sheath is quite difficult to treat, with ruptures in zone 2 carrying the worst prognosis for the restoration of flexion. The severity of the patient's rheumatoid arthritis and articular disease has a great effect on the outcome of the reconstructive surgery. Prevention of tendon ruptures by early tenosynovectomy and the removal of bone spurs should be the goal of the surgeon. | |
| 2006041 | Evaluating arthritic complaints. | 1991 Feb | Adults with arthritic conditions are seen frequently in primary care clinics. However, more than 100 different entities can produce joint and muscle symptoms, which makes it challenging to correctly diagnose musculoskeletal complaints. There are several logical steps to follow in assessing joint disorders. The first is to differentiate between what is and what is not arthritis. Additional steps necessary for an appropriate diagnosis include analysis of a thorough history, physical examination, and laboratory and X-ray results. It is of critical importance to identify the most common forms of arthritis, as well as the specific conditions that require immediate referral. The onset, incidence, findings and pathophysiology of the following entities in the adult population are discussed: septic arthritis, osteoarthritis, rheumatoid arthritis, the crystal-induced diseases, human immunodeficiency virus (HIV) and arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus. |