Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3671990 | The nature of the onset of rheumatoid arthritis: a reassessment. | 1987 | A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or insidious), type of joint involved (small, medium, large or combined joints) and pattern of joint involvement (monarticular, pauciarticular or polyarticular) at onset, and the interval between the first symptom and development of established disease were determined from the interview (based on the patient's memory). The onset was rapid in 46%. Initial involvement occurred in small joints in 31%, medium joints in 16%, large joints in 28% and combined sites in 25%. The pattern of joint involvement at onset was monarticular in 21%, pauciarticular in 44% and polyarticular in 35%. The time for disease to become established was less than 1 month in 25%, 1-6 months in 35%, 6-12 months in 14% and over 1 year in 26%. The monarticular pattern of onset was associated with slower development of established disease than the other patterns of joint involvement; polyarticular disease tended to be associated with polyarticular onset; involvement of large joints was associated with pauciarticular onset. | |
| 2327244 | Penicillamin-induced neuropathy in rheumatoid arthritis. | 1990 Feb | A case of penicillamin-induced severe polyradiculopathy in rheumatoid arthritis is presented. The neuropathy was of demyelinating type, purely motor, proximal and clinically fully reversible when the drug ceased. In case of a progressive neuropathy, during penicillamin treatment, this adverse effect should be born in mind, and discontinuation of the drug considered. | |
| 1812555 | [The function of the bronchial system in patients with rheumatoid arthritis]. | 1991 Jul | The authors studied the functional indices of the bronchopulmonary system in 23 patients with rheumatoid arthritis. The vital capacity of the lungs (VCL), indices of bronchial patency: relation of the forced exhalation volume during the 1st second to VCL (FEV/VCL), the rate of the air flow of the forced exhalation when recording the curve the flow-volume (FEV)--peak (Vpeak), the rate in decreasing lung volumes, in 25, 50 and 75% of the whole volume of the forced exhalation (V25, V50, V75). VCL was not decreased in any of the cases, FEV1/VCL comprised 80.04 +/- 44%, Vpeak--110.30 +/- 3.30% of the norm. On the basis of these data a conclusion was made that the patency of the major bronchi was normal. V75 was decreased in 13 out of 23 patients; on the average it comprised 73.78 +/- 4.96% of the norm that significantly differs from the results obtained in healthy individuals (87.1 +/- 1.96 of the norm). An isolated decrease in terminal rates of FEV indicates the reduction of the patency of the minor respiratory ducts. A decrease in V75 was observed more often and was the more marked the longer the duration of the disease. There are no distinct connections between the pathological changes in the minor bronchi condition and the indices of the activity of the inflammatory process and humoral immunity: ESR the level of total protein, alpha 2-globulins, gamma-globulins, rheumatoid factor, circulating immune complexes. | |
| 2706055 | Knee arthroscopy after yttrium or osmic acid injection. | 1989 | This study presents the macroscopic and histologic results of 35 knee arthroscopies performed on patients with rheumatoid arthritis, some months after an yttrium or osmic acid intraarticular injection. The procedure was most often performed after a failure of the injection or a relapse of synovitis. Arthroscopy provides an understanding of the cause of synoviorthesis failure--insufficient action of the product on the synovitis or its poor diffusion, fibri-nonecrotic deposits, or cartilaginous lesions--and may be used both diagnostically and therapeutically. | |
| 2898314 | New HLA DNA polymorphisms associated with rheumatoid arthritis. | 1986 Jun | Studies of restriction enzyme fragment length polymorphisms (RFLP) have further clarified two DNA polymorphisms detected in DR4 positive individuals with a DQ beta probe. These patterns have been designated DQ beta omega, characterized in the Dw4 homozygous typing cell (HTC) BM14 and DQ beta phi, characterized in the Dw4 HTC MCF, and so do not correspond with different Dw types. These patterns clearly segregate in families with HLA haplotypes. We suggest that omega and phi may be polymorphisms of the DX beta gene. The previously reported DX alpha polymorphisms U and L were found with all DR types and in association with DQ beta omega (U) and DQ beta phi(L). In addition DQ beta phi was found to be strongly associated with TA10 positively (a subdivision of DQw3) although this association was not absolute. Associations between RFLP and other HLA Class II and I antigens seen in DR4 patients and DR4 controls suggest the existence of at least two preferential allelic associations (PAA), one containing omega/U and the other phi/L. PAA1: DX alpha U-DQ beta omega-TA10 negative-DQw3-Dw4-DR4----Bw62-Bw6-Cw3-A2 PAA2: DX alpha L-DQ beta phi-TA10 positive-DQw3-Dw4-DR4----B44-Bw4-Cw3-A2 The frequency of the omega pattern was higher, although not significantly in the RA patients compared with controls. However, a significantly higher frequency of omega was found in RA patients with extra-articular manifestations (EA) compared (a) with controls (p less than 0.04) and (h) with those patients without EA (p less than 0.05). In addition the frequency of phi was significantly higher in RA patients with nodules and/or erosions (N/ER) compared with patients without these features (p less than 0.008). When cumulative scores were assigned to patients after assessing the number of components fulfilled for each PAA, PAA1 appeared to be pronounced in patients with EA and PAA2 in patients with N/ER. The frequency of a previously reported DQ beta T6 band found with the enzyme Taq 1 and DQ-beta probe was found at a higher frequency in RA patients compared with controls. In addition a significantly higher frequency of this band was found in female RA patients compared to males. | |
| 2330291 | [Usefulness of assessing bone mineral content of cortical bone in patients with lingering | 1990 Jan 25 | The CT numbers of cortex at the level of 20 cm (CT20) and of spongiosa in the lateral condyle at 2 cm (CT02) proximally from the distal end of the femur, and the bone mineral density of spongiosa in L3 body (BMD), were obtained by QCT. The study included 48 patients with rheumatoid arthritis or chronic renal failure as well as 10 healthy volunteers. The relationships of CT20 vs BMD in the regions above and below a critical value of BMD were quite different from each other. Similar relationships were observed in the plot of CT20 vs CT02. The results indicated that the demineralization of cortex was much less than that of spongiosa while the mineral content of spongiosa kept higher than a critical value, but the demineralization of cortex surpassed that of spongiosa once the mineral content of spongiosa had become lower than the critical value. It is necessary to assess bone mineral content of cortex especially in patients with lingering imbalance of bone metabolism. | |
| 2309096 | [Tomographic aspects of the temporomandibular joint (TMJ). Comparative study of 30 subject | 1990 | From a prospective study, two populations are compared: 30 Healthy subjects with 30 subjects suffering from rheumatoid arthritis. Two conclusions are statistically significant: --The temporo-mandibular joint is affected like the other joints in the rheumatoid arthritis, --the lesions are often bilateral. Two radiographic aspects, are most often observed: the erosion and the lacuna. | |
| 2730263 | Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis. | 1989 Jun | A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity. | |
| 2157375 | Spontaneous release of angiotensin converting enzyme and interleukin 1 beta from periphera | 1990 Mar | Angiotensin converting enzyme (ACE) and interleukin 1 activities were assayed simultaneously in the serum free medium from the unstimulated peripheral blood monocytes from 32 patients with rheumatoid arthritis (RA), 11 patients with osteoarthritis, and 25 normal controls matched for age and sex. Angiotensin converting enzyme activity was raised in most (29/32) patients with RA and interleukin 1 activity (most of which was interleukin 1 beta) was enhanced in 11/32 patients with RA, while monocytes from only two patients with osteoarthritis, but from none of the controls, secreted a small amount of ACE alone in the culture condition. Monocytes from patients with early RA (disease duration less than 3 years) released significantly more ACE and interleukin 1 than those from late stage RA (disease duration greater than or equal to 3 years). | |
| 3955940 | Roentgenographic evaluation of geometric total knee arthroplasty with a six-year average f | 1986 Jan | The geometric total knee prosthesis was used in the reconstruction of 70 damaged knee joints in 56 patients from November 1973 through March 1979. The average follow-up period extended to six years and seven months. Eleven patients had died and four could not be located. Eighty-one percent of the remaining knees had little or no pain at the time of the review. Pain in the patellofemoral joints was an insignificant problem in this series. The femorotibial shaft angle ranged from 0 degrees to 10 degrees of valgus in 43 (82.7%) of 52 knees. Six knees showed varus deformity at the time of follow-up examination. Stress fracture of the medial condyle of the tibia was found in two of these six knees. The absence of a radiolucent zone at the tibial cement-bone interface was noted in only ten (19.2%) of the 52 knee roentgenograms. New formation or progression of a radiolucent zone from six to 12 months after the operation was found in 36.5%. Positional abnormality of the marker wires seen in serial roentgenograms existed in 51.9% of the knees. Nine knees (17.3%) disclosed a gap between the metallic articular surface and the tibial component and also showed the collision of the tibial intercondylar eminence against the femur in the standing position. The tibial component of the prosthesis was fractured in one knee. | |
| 2166301 | [Dynamic magnetic resonance imaging in the differentiation of inflammatory joint lesions]. | 1990 Jul | Eighteen patients with inflammatory lesions of the knee joints (ten with rheumatoid arthritis, eight with undiagnosed lesions) and two normal subjects were examined by MRI. In addition to spin-echo measurements, the signals from normal and pathological tissues were evaluated quantitatively by dynamic flash sequences following the injection of gadolinium DTPA. The latter method was able to distinguish active pannus from other proliferative synovial changes; the degree of activity could be related to synovial histology and relevant clinical features in eight patients. Areas of flat articular and subchondral pannus could be identified by the enhanced signal following the administration of gadolinium DTPA. Dynamic MRI is able to provide important information for the early diagnosis and follow-up of patients with rheumatoid arthritis. | |
| 1749732 | Corticosteroid therapy for rheumatoid arthritis. Benefits and limitations. | 1991 Dec | Oral corticosteroids, despite their potential side effects, have a select role in the treatment of rheumatoid arthritis. For articular disease, these drugs must be targeted to short-term goals, such as symptom relief. Close attention to the indications and potential hazards of steroid therapy may ensure optimal benefit and reduced risk. Intra-articular steroid injections can provide local symptomatic relief when only one or a few joints are swollen. Septic arthritis is most important to exclude before injection of a joint. Complications of intra-articular injection are few, and relief may be long-lasting. | |
| 3184069 | The value of the joint alignment and motion scale in rheumatoid arthritis. | 1988 Aug | Spiegel, et al proposed for the first time in 1986 the inclusion of the Joint Alignment and Motion (JAM) Scale in the evaluation of patients with rheumatoid arthritis. Our 2-part study attempted to (1) measure the interobserver reliability of the instrument (therapist, occupational and physical vs physician) and (2) determine the relationship between it and disease severity as determined radiographically by means of the modified anatomical grading criteria, and functionally by the ARA functional class. Thirty patients were included in each part of the study. Our data indicate that the quick, inexpensive JAM Scale of Spiegel, et al is a reliable method of estimating joint motion and alignment and correlates with both functional class and disease severity. | |
| 2375171 | [Model of complex medical rehabilitation of rheumatoid arthritis--possibilities and proble | 1990 Mar 15 | The complex rehabilitation of the patients suffering from rheumatoid arthritis requires an interdisciplinary cooperation and a reasonable coordination of all involved persons of the territory. Taking an example of the Rostock county the possibilities and problems hereby arising are illustrated. | |
| 3599003 | A strategy for reaching therapeutic salicylate levels in patients with rheumatoid arthriti | 1987 Apr | After one to 2 weeks of 45 mg/kg/day choline magnesium trisalicylate (CMT) in 2 divided doses, 51 of 71 patients with rheumatoid arthritis (72%) had observed steady state serum salicylate concentrations between 150 and 300 mg/l (mean salicylate: 213 +/- 10 mg/l), although 17 later required dose adjustment. CMT dosing was changed in 37 cases by using the formula: dosing rate = total clearance X concentration. The expected and observed concentrations were not different (p = 0.31); thus, this formula can help calculate salicylate dosing changes to bring the serum salicylate level to within the therapeutic range. | |
| 3565525 | A program for improving energy conservation behaviors in adults with rheumatoid arthritis. | 1987 Feb | This paper presents the design and evaluation of an occupational therapy program developed at the National Institutes of Health for teaching energy conservation and joint protection to adults with rheumatoid arthritis. An existing model for educational diagnosis in health education was used to identify program, behavioral, and educational objectives for the new program. The use of this model resulted in measurable objectives, which were used as outcome measures in the randomized research evaluation of the new program. The dependent variables measured were activity-of-daily-living status, psychosocial adjustment to illness, knowledge, disease activity, pain, and fatigue. None were significantly different after the intervention. The independent variables measured included components of balancing rest and physical activity. After 3 months, a greater percentage of the subjects receiving the workbook-based occupational therapy program than those receiving traditional occupational therapy demonstrated an application of the behaviors the intervention was designed to change. | |
| 3485395 | Bronchoalveolar lavage fluid evaluation in rheumatoid arthritis. | 1986 Mar | Rheumatoid arthritis (RA), a systemic disorder of unknown cause, is associated with a variety of well-recognized pulmonary abnormalities including interstitial lung disease. To investigate possible pathogenic events in this disorder, we performed bronchoalveolar lavage (BAL) in 24 patients with classic or definite RA. Using radiographic and physiologic parameters as well as BAL cell differentials, 3 distinct groups emerged. Group I consisted of 9 patients with evidence of clinical interstitial lung involvement. Group II consisted of 5 patients without evidence of clinical interstitial lung disease (normal chest roentgenogram and functional testing) but who had abnormal BAL cellular differentials. The 10 remaining patients (Group III) had no evidence of clinical interstitial lung disease and had normal BAL cell differentials. Bronchoalveolar lavage in Group I had a significantly increased percentage of neutrophils (12.4 +/- 4.2; p less than 0.05) compared with Group II (2.4 +/- 0.8) and Group III (2.9 +/- 0.6). All patients in Group II had elevated BAL lymphocytes (24.4 +/- 6.4) compared with Group I (10.1 +/- 3.8; p greater than 0.05) and Group III (5.4 +/- 0.7; p less than 0.01). Both Groups I and II had detectable IgM in BAL (0.02 +/- 0.01 and 0.04 +/- 0.02 mg/mg of albumin, respectively), whereas Group III patients and normal control subjects did not (p less than 0.01). There was a marked reduction in BAL T-lymphocyte Leu 3/Leu 2A (helper/suppressor) cell ratios in Group I (0.92 +/- 0.02; p less than 0.05) compared with Group II (2.6 +/- 0.6) and Group III (1.6 +/- 0.1).(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2717698 | [The significance of stressful life events and their management in patients with rheumatoi | 1989 Mar | In a multivariate approach critical life events and coping in 126 patients with rheumatoid arthritis, hypertension and gastrointestinal ulcers as well as healthy persons are researched with regard to their nosological meaning and their relationship to relevant clinical parameters. They answered a multi-dimensional coping questionnaire and an inventory which measures and evaluates individual relevant life events. With regard to this, different clinical information war processed. On the basis of the above named parameters, the four groups could be distinguished from one another. The interrelationship between psychosocial variables and clinical indices can be neglected. | |
| 3725124 | [Evaluation of the efficacy of orgotein in a series of patients with hydrarthrosis of the | 1986 May 19 | A study was carried out to verify the efficacy of intra-articular orgotein in patients with different forms of hydrarthrosis of the knee. The results confirm the value of orgotein for the local treatment of osteoarthritic joint swellings. However in the presence of marked exudative synovitis processes (chronic primary polyarthritis), the use of orgotein is of limited value. | |
| 2126285 | Major joint replacement surgery for rheumatoid arthritis. | 1990 Dec | The results of total joint arthroplasty are exciting but certainly they are not yet good enough to warrant complacency. Further advances in design and materials are required. It is also clear that there is a positive relationship between the technical expertise with which the surgery is performed and the long term functional results (especially with regard to the knee). Nonetheless, the benefits that this type of surgery can confer on the severely afflicted rheumatoid patient with regard to pain relief and function are such that there should be little hesitation in offering this form of treatment to all patients who fail conservative treatment. However, it has always to be remembered that the results of even the most sophisticated surgery can be improved by an intensive rehabilitation programme including pre- and post-operative occupational therapy and physiotherapy, the prescription of appropriate appliances and the optimisation of medical therapy. |