Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2063006 | Infectious and inflammatory processes of the spine. | 1991 Jul | Infectious and inflammatory processes of the spinal column are discussed, including disc space infection, osteomyelitis, epidural abscess, arachnoiditis, and rheumatoid arthritis. The relative sensitivity and specificity of various imaging modalities, as well as the imaging characteristics and utility of these various modalities are given. Emphasis is placed on the use of magnetic resonance imaging. | |
| 3710608 | Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and res | 1986 | Toxic epidermal necrolysis with epidermal shedding over almost the entire body occurred in a patient with classical rheumatoid arthritis treated with sulindac, penicillamine and a combination analgesic containing paracetamol and chlormezanone. Erosions in the lower respiratory tract and the intestine contributed to a lethal outcome of the disease and showed a microscopical picture similar to that of the skin involved. The histopathological picture of these extracutaneous lesions have been only briefly reported previously. | |
| 2075372 | Synovial fluid fibronectin fragments: no evidence for a mitogenic effect on fibroblasts. | 1990 | Fragments of bovine plasma fibronectin produced by cathepsin D digestion are reportedly mitogenic for hamster fibroblasts. Rheumatoid arthritis synovial fluid contains many fibronectin fragments, which may contribute to the proliferation of synovial cells. We have therefore investigated the potential of fibronectin fragments to stimulate proliferation of synovial fibroblast-like cells using human material. Affinity-purified human plasma and synovial fluid fibronectin was digested with cathepsin D at pH 3.5 for 0-18 h and proteolysis stopped with pepstatin. A variety of fragments were produced ranging from 50 to 200 kDa when analysed by SDS-PAGE. The proliferative activity of various test preparations was studied using quiescent human skin and synovial fibroblasts. Tests were applied for 24 h to 10(4) cells and DNA synthesis measured by tritiated thymidine incorporation. Both undigested and peptides of fibronectin consistently failed to stimulate DNA synthesis in fibroblasts at all concentrations tested, compared with a phosphate-buffered saline control. This was in marked contrast to human synovial fluid from either rheumatoid arthritis or osteoarthritis patients, which stimulated DNA synthesis in the same system (P less than 0.01). Therefore, our data do not confirm the findings of previous studies in which animal materials were used. We can find no evidence that fibronectin fragments play a role in stimulating synovial proliferation in inflammatory arthritis. | |
| 2378173 | [Importance and value of roentgen studies as outcome criteria in rheumatoid arthritis]. | 1990 May | In order to evaluate the objectivity and validity of radiographic parameters in rheumatoid arthritis (RA) we studied 56 patients with definite RA. Inter-observer variation was assessed comparing the scorings (Larsen classification) of two independent experienced observers. Total radiographic scores were highly significantly correlated (r = 0.89). Yet, we could not find relevant associations between radiographic findings and clinical outcome parameters (pain, morning stiffness, dexterity, grip strength, and patient's overall assessment). Thus, hand radiographs in RA provide highly reproducible results. Its validity concerning patient outcome, however, has to be interpreted very carefully. | |
| 3396247 | The nature and designation of osteoarthritis determined by its histopathology. | 1988 Jan | Specimens of synovial tissue and articular cartilage removed at operations of patients with primary degenerative joint disease were scrutinized for defined histopathological parameters. The findings in the synovial membrane were subsequently compared as to frequency and intensity with identical parameters ascertained in specimens removed from patients with definite rheumatoid arthritis. These examinations disclosed the presence of synovial inflammatory features, although at lesser incidence and intensity than in rheumatoid arthritis; therefore the designation of arthritis is indicated. On the basis of the concurrently examined tissue specimens of the articular cartilage, and in consensus with the generally acknowledged start of the degenerative joint disease by disintegrating changes in the articular cartilage, the prefix of chondrosis is appropriate. | |
| 2664988 | [Significance of the changes in the level of expression of HLA antigens on the surface of | 1989 Jan | The authors calculated sensitivity, specificity, informativeness and diagnostic coefficient and relative risk of the joint index reflecting the degree of T-lymphocytes activation in patients with RA as compared with healthy persons and patients in the control group. | |
| 3535983 | Lack of effect of total body irradiation in rheumatoid arthritis. | 1986 Nov | We are reporting a pilot study of total body irradiation in six patients with progressive rheumatoid arthritis, who had previously received gold and penicillamine. Radiation (150 cGy) was administered in ten fractions over 5 weeks. There was a transient pancytopenia following radiotherapy and the total peripheral lymphocyte count remained below pre-treatment levels after 6 months. There were no serious short-term adverse effects. By 6 months, there was no evidence of any change in clinical and laboratory estimates of disease activity. We feel that further studies of this regimen in intractable rheumatoid arthritis are not justified. | |
| 2790404 | Synovial and serum levels of methotrexate during methotrexate therapy of rheumatoid arthri | 1989 Oct | Methotrexate (MTX) levels were studied following intravenous MTX in both serum and synovial fluid (SF) of rheumatoid arthritis patients. Two hours after injection serum MTX levels were higher than those of SF. At 24 hours SF levels of MTX exceeded those of the serum, while at 72 hours both blood and SF concentrations were undetectable. The localization of parenteral MTX in the SF may have importance in the understanding of its mechanism and site of action in rheumatoid arthritis. | |
| 2476866 | [Clinico-immunologic analysis of sorption methods of treatment of rheumatoid arthritis and | 1989 | The paper is concerned with the results of the application of the sorption methods for the treatment of patients with rheumatoid arthritis and systemic lupus erythematosus. The authors show the advisability of the use of the above methods for different variants of the disease course, define the time of the treatment and complications common to the sorption methods of the treatment. The results of the treatment by hemoperfusion and enterosorption are compared with the results of the patients' treatment with immunodepressants. A study was made of the action of the sorption methods and immunodepressants on the blood content of the main autoantigens and autoantibodies capable of participation in the forming of the immune complexes. The concentration and the qualitative composition of the circulating immune complexes were studied in the course of the treatment. | |
| 3484956 | Rheumatic diseases in an Inuit population. | 1986 Jan | Prevalence and incidence rates for rheumatic diseases were found to be minimal among the Inuit people in the Keewatin District of the Northwest Territories, Canada. Patient identification was achieved by a review of medical records. All identified patients were interviewed and examined by a participating rheumatologist. Among women, the prevalence of rheumatoid arthritis, adjusted for age of the Manitoba population, was 1,822 per 100,000 and was comparable with that observed in other populations; no cases of rheumatoid arthritis in men were confirmed. The age-adjusted prevalence of osteoarthritis, 1,219 per 100,000 in men and 2,144 per 100,000 in women, was apparently low. A moderately high incidence of Reiter's syndrome, 24.9 per 100,000, was found. The findings in children suggested a high frequency of seronegative spondylarthropathies (yearly incidence 60.1 per 100,000), although the adjusted yearly incidence for juvenile rheumatoid arthritis also appeared to be high, 23.6 per 100,000. The frequencies of HLA antigens in patient groups were compared with those found in 19 patients with musculoskeletal complaints but no rheumatic disease. Both HLA-B27 and HLA-DR4 appeared to be common in these controls, 36.8% and 63.2%, respectively. Nevertheless, there was a higher frequency of HLA-B27 in patients with seronegative spondylarthropathies (87%) than in controls (P = 0.001). Because of the small numbers of patients who had rheumatoid arthritis, no associations with HLA were made for this condition. Although the findings suggest differences in the distribution of rheumatic diseases compared with those found in other populations, more complete studies are required to confirm these observations. | |
| 1859490 | Methotrexate versus azathioprine in the treatment of rheumatoid arthritis. A forty-eight-w | 1991 Aug | We conducted a double-blind, randomized trial comparing azathioprine (AZA) and methotrexate (MTX) in the treatment of patients with rheumatoid arthritis in whom parenteral gold and/or D-penicillamine treatment had been unsuccessful. Patients were randomly assigned to receive either AZA (100 mg daily) or oral MTX (7.5 mg weekly). After 8 weeks, the dosage was increased depending on the clinical improvement. Sixty-four patients were followed up for 48 weeks (33 AZA, 31 MTX). Comparison of values at week 24 with baseline values revealed significant improvement in 12 of 13 disease variables in the MTX group and in 6 of 13 in the AZA group. Comparison between the 2 treatment groups at 24 weeks, by area-under-the-curve analysis, showed significantly more improvement in the MTX group in terms of the swollen joint count, pain score, erythrocyte sedimentation rate, C-reactive protein level, hemoglobin level, thrombocyte level, and disease activity score. A significant overall clinical improvement (disease activity score) was found in 7 of 20 patients treated with AZA and 18 of 30 patients treated with MTX after 24 weeks of therapy, and in 6 of 12 AZA-treated patients and 19 of 25 MTX-treated patients after 48 weeks. The number of withdrawals due to side effects was significantly higher in the AZA group. After 48 weeks, only 12 patients from the AZA group (36%), but 25 from the MTX group (81%), were still using the initial drug. These results demonstrate MTX to be superior to AZA in the treatment of rheumatoid arthritis, with a more rapid clinical improvement which is sustained after 1 year, accompanied by a lower rate of serious adverse reactions. | |
| 3382268 | Alterations in appendicular skeletal mass in patients with rheumatoid, psoriatic, and oste | 1988 Jun | Appendicular bone mass was measured in a series of 50 patients with non-steroid treated rheumatoid arthritis, 20 with polyarticular seronegative psoriatic arthritis, and 30 with osteoarthrosis, and compared with that of 40 controls of similar age and sex. Distal forearm bone mineral content was reduced in patients with rheumatoid and psoriatic arthritis and increased in those with osteoarthrosis. The increase in bone mass in patients with osteoarthrosis was confined to those with isolated large joint disease and was not found in those with primary generalised osteoarthrosis. | |
| 2799008 | [Long-term results of surgical synovectomies of the rheumatoid wrist. Apropos of 60 cases] | 1989 | Sixty rheumatoid wrists operated on for tendon articular synovectomies and resection of the ulnar head have been reviewed with an average follow-up of 5 years and 4 months. One-third of these patients who presented an average follow-up of 8 years and 8 months have been isolated for the radio-clinical analysis. The results on pain are good (78 per cent of patients are painless at 5 years and 67 per cent at 8 years); 80 per cent present no recurrence of tenosynovitis, and 75 per cent show a functional improvement. The study of mobility sectors shows a loss of 28 per cent on the sagittal plane and 21 per cent on the frontal plane at 5 years, which increases respectively at 33 per cent and 41 per cent at 8 years, with however a sector of useful mobility preserved. The prehension strength decreases but the parameter must take into account the polyarticular evolution of the disease. If long-term results are clinically satisfactory, isolated synovectomy does not prevent radiological aggravation which is due to the evolution of the disease. This is the reason why, prevently, intracarpal arthrodeses or tendon transfers must also be performed, when there are signs of instability or partial wrist destructions. | |
| 3058971 | The diagnostic significance of the antiperinuclear factor for rheumatoid arthritis. | 1988 Sep | Sensitivity and specificity of antiperinuclear factor (APF) determination were assessed in 127 patients with classical or definite rheumatoid arthritis (RA). The control population consisted of 262 patients with rheumatic complaints other than RA. Our results showed a sensitivity of 86.6%, a specificity of 96.2% and a Youden index of 82.8% for APF in RA. In 14.2% of the total population with RA the rheumatoid factor (RF) became negative in the course of the disease; all but one were found to be actually APF positive. Of the population with RA analyzed, 8.6% were consistently RF negative but APF positive. In view of its strong sensitivity and specificity for RA, APF determination is a valuable serological tool for the diagnosis of the disease. In APF positive, RF negative patients with RA the prognosis seems to be poor. | |
| 3492194 | Inhibition of complement-mediated solubilisation of antigen-antibody complexes by serum fa | 1986 Aug | Control of immune complex formation is important to limit disease resulting from their deposition in tissues. Any inhibition of immune complex solubilisation is thus significant in the pathogenesis of immune complex diseases. More than half of our patients with various rheumatic connective tissue diseases were demonstrated to have serum inhibition of immune complex solubilisation (12/16 rheumatoid arthritis, 22/37 systemic lupus erythematosus, 16/29 primary Sjogren's syndrome, and eight of nine with mixed connective tissue disease). This serum inhibitory activity did not correlate well with serum levels of IgM rheumatoid factor or circulating immune complexes, and its nature remains to be elucidated. | |
| 2769670 | Multiple rheumatoid bursal cysts. | 1989 Jul | We have encountered a patient with rheumatoid arthritis (RA) who developed multiple subcutaneous swellings containing sterile milky fluid. The resected material showed chronic granulomatous changes compatible with rheumatoid inflammation. We suggest that multiple chronic rheumatoid inflammation may occur in the bursae as well as joint synovium as one of the extraarticular manifestations of RA. | |
| 2663287 | Bipolar hip arthroplasty in rheumatoid arthritis. | 1989 Jul | Bipolar hip arthroplasty with bone grafting was performed on 25 joints with rheumatoid arthritis from 1981 to 1985. The results and roentgenographical progress of the grafted bone were followed for a minimum of two years, the longest follow-up examination occurring six years after the operation. The clinical score was assessed by the hip rating score of the Japanese Orthopaedic Association, which assigns a maximum of 100 points. The preoperative clinical score ranged from 22 to 59 points (mean, 42.6). The postoperative score improved to a range of 65-92 points (mean, 72.8). Of 24 hips examined, 21 (87.5%) were painless. As measured serially from the roentgenograms made immediately after the operation, the overall distance of central migration in 24 hips was 0-8.5 mm (average, 2.7 mm). The overall distance of superior migration in 24 hips was 0-10 mm (average, 3.7 mm). A single massive bone graft using extracted femoral head was considered to be better than bone fragments as the procedure for acetabular reconstruction during bipolar hip arthroplasty in rheumatoid arthritis. | |
| 2959773 | The assessment of pain in rheumatoid arthritis: disease differentiation and temporal stabi | 1987 Aug | An observation method for the assessment of pain behaviors in patients with rheumatoid arthritis (RA) has been developed. We investigated the extent to which the frequencies of pain behaviors differentiated patients with RA and patients with chronic low back pain from depressed and nondepressed, pain free, control subjects. The reliability of the pain behavior frequencies of patients with RA across 2 observation sessions also was determined. Total pain behavior scores clearly differentiated patients with RA and low back pain from depressed and nondepressed, pain free, control subjects. Pain behavior observed in patients with RA showed a high degree of stability over time. The results of our study suggest that the behavioral observation method will prove useful in the assessment of RA pain in clinical and research settings. | |
| 2057711 | [Difficulties in the evaluation of the basic treatment of rheumatoid polyarthritis: a role | 1991 Apr | Evaluation of the efficacy of basic treatment of rheumatoid arthritis comes up against a large number of difficulties: absence of any single validated criterion in the form of a composite index with weighting of different factors, need for long term trials without any change in combined treatment and difficulties keeping all patients in such trials until their completion. These problems have led to the use of global evaluation as activity criterion, accepting treatment withdrawals and changes in combined treatment. This conversion of explicative trials to pragmatic trials results in difficulties in their interpretation. Trials based upon a pragmatic approach using quality of life scales are efficacy criterion should resolve some of methodological problems which may be encountered in the evaluation of basic treatment of R.A. Quality of life scales investigate three essential areas: physical activity, the social dimension and the psychological domain of emotional existence. Certain specific questionnaires such as "AIMS" are particularly suitable for rheumatological use. These quality of life scales are designed to quantify the usefulness of basic treatment, enabling evaluation which completes knowledge which may be acquired in terms of efficacy in explicative trials. | |
| 3580007 | Increase of dihydrofolate reductase in peripheral blood lymphocytes of rheumatoid arthriti | 1987 Apr | Because of a previously observed plateau of clinical response after long-term methotrexate (MTX) therapy for rheumatoid arthritis (RA), we investigated whether such treatment might lead to acquired resistance to the drug. We studied the activity of dihydrofolate reductase (DHFR) (the target enzyme of MTX) in peripheral blood mononuclear cells of 11 RA patients who had been treated with MTX for a median of 43 months. The enzyme levels were markedly increased compared with levels found in the cells of 6 RA patients treated with other slow-acting drugs. Quantitative dot-blot analysis of DNA from 7 of these patients showed no evidence of DHFR gene amplification. No correlation was observed between increased levels of DHFR and either response to therapy or to the weekly MTX dosage. Phytohemagglutinin-stimulated peripheral blood lymphocytes from 6 patients with increased levels of DHFR showed no evidence of MTX resistance in vitro. The increased DHFR levels may result from binding of MTX to the enzyme, which may block the normal degradation pathways; they do not appear to be a marker of impending drug resistance. |