Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3318431 | Single-blind comparative study of nabumetone (Relafen) versus naproxen in the treatment of | 1987 Oct 30 | Forty-seven patients with active rheumatoid arthritis were entered into a single-blind study to compare the safety and efficacy of nabumetone with naproxen. Patients were randomly assigned to receive a daily dose of 2 g of nabumetone or 1 g of naproxen after a placebo-washout period of at least three days. In addition to the usual clinical and laboratory measurements of disease activity, thermographic assessment was carried out at each visit and the heat distribution index was calculated. In addition, the safety and tolerance were assessed. Patients had improvement in severity of pain, severity and duration of morning stiffness, and articular index, and there was no statistical difference between the two treatment groups. By the end of six months, 13 patients had withdrawn from treatment; five patients in the naproxen treatment group and five in the nabumetone group were withdrawn from the study due to lack of efficacy. In no patient from the nabumetone group did an adverse reaction develop. In one patient in the naproxen group, a severe decrease in white blood cell count developed, and a skin rash and swollen gums developed in another patient. We conclude that nabumetone is well tolerated and of equal efficacy to naproxen in the treatment of active rheumatoid arthritis. | |
| 1753548 | [A case of follicular bronchiolitis with broncho-pleural fistula in rheumatoid arthritis]. | 1991 Sep | A 67-year-old male diagnosed clinically as having rheumatoid pleuritis and bronchiolitis was treated with adrenocorticosteroid. His clinical findings improved, but following the tapering of the steroid dose, exacerbation occurred. After the steroid dose was increased, serological findings improved, but chest X-ray findings revealed no improvement. To re-evaluate the etiology of the bronchiolar lesion, open lung biopsy was performed. The biopsy specimen showed lymphocytic infiltration and formation of lymphoid follicles in and around the bronchioles. The pulmonary lesion was diagnosed as follicular bronchiolitis. | |
| 1880171 | Excision of the distal ulna in rheumatoid arthritis. | 1991 May | Resection of the ulna is an effective operation in the treatment of rheumatoid disorders of the distal radioulnar joint. Tenosynovectomies of the overlying extensor tendons and synovectomy of the joint are integral parts of the procedure. Following resection, the ulna usually remains in alignment with the radius, although some dorsal displacement is common. Restoring stability to the ulna as well as reconstructing a new sheath for the extensor carpi ulnaris can be accomplished in most cases by using the extensor retinaculum. In those cases where the retinaculum has been destroyed by the disease process or when the distal ulna is severely displaced, stability can be restored using the extensor carpi ulnaris for a tenodesis. | |
| 2285739 | Educational and psychosocial needs of patients with chronic disease. A survey of preferenc | 1990 Mar | There is increasing interest in better defining and meeting the nonmedical needs of patients with chronic diseases, such as rheumatoid arthritis (RA). We surveyed patients with RA about the importance of eight psychosocial and eight educational issues, and asked patients from what source they preferred to get help with these issues and which sources they would not use. We also looked at individual variables, including sex, age, disease duration, and disease severity, to see if they affected patients' choices. The issues rated most important by patients included communicating with the doctor, understanding medication, dealing with pain, and the effects of arthritis on energy level, the future, and work. Most patients preferred to seek help from their physicians, although up to 75% were willing to attend groups, and 68% were willing to see individual counselors for some issues. | |
| 3040582 | [Endocrine rhythms in patients with rheumatoid arthritis: possible neurohormonal influence | 1987 Jul | Recent studies are reporting on an influence of ACTH and prolactin in physiological dosages on the intensity of the immune response in the animal model of adjuvant arthritis. Therefore, we studied the circadian secretion patterns of ACTH, cortisol and prolactin by measurements throughout a 24-hour cycle in two-hour intervals in patients with rheumatoid arthritis with different inflammatory activity of the disease. We only investigated patients who never before were treated with corticosteroids and drugs like gold, d-penicillamine or immunosuppressive drugs. The circadian secretion patterns of cortisol and ACTH were disturbed in most patients. High inflammatory activity was accompanied by severe disturbance of the circadian rhythm, whereas patients with low inflammatory activity showed a nearly normal secretion pattern. Also the measurements of prolactin showed a tendency of loss of circadian rhythm in relation to the inflammatory activity of the disease. According to the found changes of endocrine regulation of ACTH, cortisol and prolactin, an influence of mediators of inflammation on hypothalamic centers, analogous to endogenous pyrogen in fever should be discussed. | |
| 2069083 | Recognition of IL1-activated chondrocytes in porcine articular cartilage. | 1991 | A polyclonal antiserum has been raised against interleukin 1 (IL1)-induced epitopes on the surface of porcine articular chondrocytes. Using this antiserum in immunolocalization studies we have been able to identify individual chondrocytes in situ both in experimentally activated articular cartilage and in pathological tissue from pigs with induced polyarthritis. | |
| 3715547 | Penicillamine-induced exacerbation of rheumatoid arthritis. | 1986 Jun | We have described three patients whose rheumatoid arthritis was exacerbated by penicillamine. The exacerbation was manifested as severe, disabling, febrile, symmetric polysynovitis with normocomplementemia, negative ANA, and reversibility upon discontinuance of the drug. The pathogenesis is yet to be determined. | |
| 2397546 | [Treatment of rheumatoid arthritis with low doses of multi-glycosides of Tripterygium wilf | 1990 May | Thirty two cases of rheumatoid arthritis were treated with multi-glycosides of Tripterygium wilfordii (T2) in a dosage of 30 mg daily for 12 weeks. Significant improvements in clinical and laboratory variables were observed. In comparison with the results of routine dose of T2 (60 mg per day) treatment, there was no significant difference to be seen between the two treatment plans. Meanwhile, symptom of rash and slightly alimentary canal lower incidences and milder manifestations of side effects of T2 were found in the patients of low dose group than in that of routine dose group. It is suggested that it is reasonable to choose the dose of 30 mg daily as the routine treatment for rheumatoid arthritis patients. | |
| 2080488 | [Methotrexate. Pharmacology applied to the treatment of rheumatoid arthritis]. | 1990 Nov | Methotrexate (MTX) is used increasingly for the treatment of rheumatoid arthritis (RA). It is an antagonist of folic acid. For the low doses used in RA (less than 15 mg/week), MTX is completely and rapidly absorbed with an active process membrane transport. The frequent toxic effects of this drug (hepatotoxicity, hematologic or possible long-term oncogenicity) limit its widespread use. MTX is as effective in treating RA as the other second line drugs and always more rapidly effective, perhaps because of anti-inflammatory properties. MTX must at the present time be used only in severe RA, refractory to more than one classical slow acting drug. Despite this, it is an extremely promising new agent in the therapy of rheumatic diseases. | |
| 3820199 | The age of death of the parents of patients with rheumatoid arthritis: a preliminary study | 1986 Oct | The hypothesis was tested that the shortened life expectancy of patients with rheumatoid arthritis (RA) is, partially at least, due to a familial factor which independently shortens life expectancy, whether the person has RA or not. We therefore compared the ages of death of the parents of patients with RA with the ages of the death of the parents of a control group. The parents of the patients with RA had a mean age of death of 64.76; 18.23 years versus 68.29; 18.24 years for the parents of the control group (p = 0.006). This finding is compatible with the hypothesis: whether genetic or environmental factors are involved is unknown. | |
| 3133153 | HLA-A,-B, and -DR antigens in relation to gold and D-penicillamine toxicity in Greek patie | 1986 Jun | Ninety-five rheumatoid arthritis patients treated with aurothiomalate and/or D-penicillamine have been studied for possible associations between HLA-A, -B, -DR antigens and various toxic reactions to the above drugs. HLA-DR3 and -DRw6 had a higher frequency in patients with toxic reactions (all types) than in patients without toxic reactions (28.5 per cent vs 13.0 per cent and 26.5 per cent vs 4.3 per cent, chi 2 = 2.6 and 7.2, respectively). HLA-B8 was found at a higher frequency in patients with proteinuria and other types of renal involvement (20.0 per cent vs 7.4 per cent in controls), whereas skin manifestations were mainly associated with the presence of HLA-DRw6. The lowest frequency of side-effects was seen in patients with HLA-DR1 and DR2 (10.2 per cent vs 28.3 per cent and 28.5 per cent vs 54.3 per cent, chi 2 = 3.9 and 5.5, respectively). In addition, seropositive patients possessing HLA-DR1, showed toxic reactions less frequently. | |
| 3213277 | [Coping with illness in rheumatoid arthritis]. | 1988 | Rheumatoid arthritis, a lifelong chronic disease, creates serious psychosocial as well as medical problems. We investigated coping with rheumatoid arthritis in 50 patient. The examination of coping-strategies used by R. A.-patients seems to show no fundamental difference to the coping behavior of patients with other chronic diseases. Biomedical conditions of the disease (Rheumafactor sero-positiv, sero-negativ) are related to different coping-strategies. Patient without psychiatric problems have a better medical health condition and, compared to depressive R. A.-patient prefer more active and optimistic coping. However, the context between psychological well-being and health (before the onset of R. A.), coping, adjustment to illness, and course of the illness is unclear. | |
| 1903707 | Diversity in antigen recognition by Mycobacterium tuberculosis-reactive T cell clones from | 1991 May | In a previous study we have shown that synovial fluid mononuclear cells from many rheumatoid arthritis (RA) patients exhibit an enhanced response to M. tuberculosis antigens as compared to peripheral blood mononuclear cells. The 65-kDa heat-shock protein of M. tuberculosis was shown not to play an important role in this response, therefore other mycobacterial proteins must be involved. In this study we have investigated the possibility that synovial fluid T cells from RA patients predominantly recognize a limited number of M. tuberculosis antigens, as a result of a lesion-specific activation of only those M. tuberculosis-reactive T cells that have cross-reacted with joint-related autoantigens. From the synovial fluid of four RA patients M. tuberculosis-reactive T cell clones were isolated and analyzed for their phenotype, HLA-DR restriction and proliferation to immunoblot fractions containing sodium dodecyl sulfate-polyacrylamide gel-separated M. tuberculosis proteins of known molecular weight range. The overall M. tuberculosis immunoblot recognition pattern of the clones was strikingly heterogeneous. Within a panel of 15 clones 12 different antigenic specificities could be distinguished. In other words, we did not observe a dominant recognition of a few M. tuberculosis antigens by synovial fluid T cells. This argues against the hypothesis that the elevated synovial T cell reactivity against M. tuberculosis is a reflection of an in vivo expansion of a limited number of different types of M. tuberculosis-reactive T cells as a result of a cross-reaction with putative joint autoantigens. | |
| 3730736 | Reduction of skin collagen with increased skin thickness in postmenopausal women with rheu | 1986 Aug | Thirty postmenopausal women with rheumatoid disease were investigated with skin biopsies and radiological measurements of skin thickness. When compared with menopausal-age-matched controls, the rheumatoid patients had significantly reduced skin collagen content and increased skin thickness. | |
| 2091904 | Collagen autoimmunity to rheumatoid arthritis. | 1990 Aug | In this study, 26 patients with rheumatoid arthritis (RA), 10 with gout, 8 with scleroderma and 10 healthy volunteers were included. Antibodies to native and denatured human collagen types I, II and III were measured by an enzyme linked immunosorbent assay (ELISA). The frequencies of antibodies to native collagen type II were 19% in the sera of 26 patients with RA. These antibodies were also cross-reacted with collagen types I and III and generally, their activities to collagen in synovial fluids were higher than that in the serum. Only one in 8 patients with scleroderma showed high serum antibodies to these collagens. However, levels of collagen antibodies in patients with RA were not correlated with levels of rheumatoid factor, IgG, IgM and IgA. There was no different in the interleukin (IL)-1 production by synovial cells stimulated by collagens from patients with either RA or gout. The correlation between anti-collagen antibodies and HLA-DR4 antigen was poor, though the presence of DR4 was common in patients with RA. These evidences suggest that collagen antibodies were important to joint pathology only in some of the patients with RA. Thus, collagen autoimmunity warrants further investigation. | |
| 3340399 | Tarsorrhaphy for corneal disease in patients with rheumatoid arthritis. | 1988 Jan | We report two patients with keratoconjunctivitis sicca and rheumatoid arthritis whose corneal surfaces regained their integrity following tarsorrhaphy when conservative therapeutic measures were unsuccessful. We suggest that tarsorrhaphy be considered early in the course of the disease in such patients when other measures have failed to arrest progressive thinning of the cornea. | |
| 2377864 | [The efficacy of dimethyl sulfoxide in secondary amyloidosis in patients with rheumatic di | 1990 Jan | The author studied the efficacy of dimethylsulfoxide (DMSO) in 26 patients (22 patients with rheumatoid arthritis, 3--with Bechterew's disease, I--with psoriatic arthropathy) with recurrent amyloidosis with predominant affection of the kidneys. The control group was given colchicine (15 patients with rheumatoid arthritis, one patient with Bechterew's disease and one with psoriatic arthropathy). It has been shown that DMSO given in a daily dose much smaller than usually recommended provides a therapeutic effect (improves the function of the kidneys) already in 1-1.5 months of peroral administration irrespective of the presence of the signs of renal insufficiency; it exceeds the effect of colchicine. DMSO is well tolerated. | |
| 3579383 | Functional assessment of the hand: reproducibility, acceptability, and utility of a new sy | 1987 Mar | A new system for measuring strength of the hand using a torsion dynamometer linked to a microprocessor is described. The system permits analysis of timed squeezes of both grip and pinch and is adjustable to all sizes of hand and degrees of hand deformity. Results obtained with the system were found to be reproducible, and the rigid device was acceptable to a group of patients with arthritic hands. In rheumatoid arthritis there is a marked reduction in maximum grip and pinch strength, together with a prolongation of the time taken to reach this maximum, and increased fatigue. The limitations of grip strength as a measure of function of the hand are discussed. | |
| 3730735 | Bone loss in rheumatoid arthritis and primary generalized osteoarthrosis: effects of corti | 1986 Aug | The annual rate of bone loss in rheumatoid arthritis (RA) and primary generalized osteoarthrosis (PGOA) was determined by measurement of total body calcium (TBCa). The mean annual rate of bone loss in 24 patients with RA treated with nonsteroidal anti-inflammatory drugs (NSAIDs) alone was 3.4%. This rate of bone loss was not reduced in ten RA patients responding to suppressive antirheumatic drugs (4.3%) or seven patients receiving oral calcium supplements (4.5%). The mean annual rate of loss of TBCa in 19 patients with PGOA was 1.6%, a figure which probably represents age-associated bone loss. The rate of bone loss in PGOA was significantly less than that in RA patients not receiving corticosteroids. The mean annual rate of change of TBCa in 30 RA patients receiving corticosteroids (+0.7%) was significantly less than that in any of the other RA groups despite an initial normalized bone mass which was significantly less than in those RA patients receiving NSAIDs alone. The data supported the hypothesis that bone loss occurred early in the course of corticosteroid therapy and thereafter the drugs might have a protective effect on the loss of bone in RA. | |
| 3663512 | Blunted erythropoietin response to anaemia in rheumatoid arthritis. | 1987 Aug | The relationship of serum immunoreactive erythropoietin to haemoglobin concentration was defined for 54 patients with rheumatoid arthritis (RA) and 41 patients with anaemia of varying aetiology (excluding pregnancy and renal insufficiency), not associated with RA. Significant inverse correlations between the logarithm of serum immunoreactive erythropoietin and the haemoglobin concentration were noted for the anaemic patients in both groups. The regression line for the RA patients had a similar slope, but a significantly lower y-intercept as compared to that for the non-RA patients. Erythropoietin levels were also significantly lower for the group of RA patients than for the group of non-RA patients when matched for comparable haemoglobin concentrations. These studies suggest that the erythropoietin response to anaemia in RA is intact but blunted relative to that for anaemia of other aetiologies. Lower levels of serum erythropoietin in anaemic RA patients may contribute to the pathogenesis of their anaemia. |