Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2198738 | [Music for rheumatism--a historical overview]. | 1990 May | The history of the use of music to lessen the pain of rheumatism is seen in the use of musical therapy in medicine as a whole. Sources citing the use of music specifically in rheumatism are rare; often, rather than rheumatism, terms like "gout (podagra)" or "joint-pain" are mentioned. This is connected with the obscure and pathognomic perceptions of rheumatism. In the archeo-medicine and for primitive cultures the considered potency of music was primarily dominated by animistic thinking. In antiquity humoral pathology developed a philosophy that tried to explain the benefits of music, even for rheumatism, but found little acceptance. In the Middle Ages and in the Baroque period iatromechanistic conceptions determined music as useful in fight against pain. In the Romantic period there was speculation about music as a causal therapy, but it was shortlived. In the 20th century music is applied as an active therapy in the care of persons suffering from rheumatism; its empiric success as a remedy in rehabilitative and palliative therapy is recognized. | |
| 3234089 | [Long-term comparison of the "St. Georg" knee endoprosthesis system. 10-year survival rate | 1988 Nov | A comparison of results between the total hinge and the sled prosthesis "St. Georg" has revealed significantly inferior results for the sled prosthesis due to a greater number of aseptic loosenings predominantly of the tibial component, primary and secondary laxity of ligaments and/or residual pain, e.g. due to malposition. The 10-years survival rate for the total hinge prosthesis was 94 per cent, thus exceeding the results obtained in total hip arthroplasty. The disadvantages of the rigid hinge models, as for instance unphysiological support and guidance and insufficient cushioning during knee motion have been compensated for in our modification, the "Endo" rotational knee prosthesis. The indications for a surface knee replacement are restricted to cases with an intact ligamentous apparatus and unicondylar arthrosis. | |
| 2850829 | Quantification of leukotriene B4 in synovial fluid by gas chromatography/tandem mass spect | 1988 Sep | A procedure for the quantification of leukotriene B4 (LTB4) in synovial fluid has been developed using gas chromatography/tandem mass spectrometry based on selected reaction monitoring of the elimination of t-butyldimethylsilanol from the ions of m/z 431 and 438 in the negative ion chemical ionization mass spectra of the di-t-butyldimethylsilyl/pentafluorobenzyl derivatives of leukotriene B4 and the internal standard (2H8)leukotriene B4. The detection limit (approximately 10 pg ml-1) is sufficiently low to permit determination of LTB4 concentration in the synovial fluid of patients with various arthropathies. Single-stage mass spectrometry was found not to be selective enough to permit quantification of LTB4 in synovial fluid. | |
| 2571463 | The role of oligosaccharides in modifying protein function. | 1989 | It has been proposed that protein-bound oligosaccharides interact with the protein to which they are attached to up- or down-regulate the bioactivity of the 'composite' glycoprotein. Oligosaccharide analyses of the glycoproteins Thy-1, tissue plasminogen activator and immunoglobulin G are presented. Correlations between particular glycoforms and enzymic activities are demonstrated for tissue plasminogen activator. The change in the prevalence of particular immunoglobulin G glycoforms is shown to correlate with disease activity in rheumatoid activity. | |
| 1814964 | Short-term effects of intra-articular sodium hyaluronate, glucocorticoid, and saline injec | 1991 Fall | The short-term effect (4 weeks) of intra-articular injections of sodium hyaluronate, glucocorticoid, and saline was studied in three groups comprising 41 patients with rheumatoid arthritis of the temporomandibular joint. Sodium hyaluronate and glucocorticoid treatments had a significant positive effect according to the patients' subjective evaluation. A comprehensive clinical dysfunction score was reduced significantly in all groups, while the number of tender muscle regions was significantly reduced and the maximum voluntary mouth opening significantly increased in the glucocorticoid and sodium hyaluronate groups only. | |
| 3265899 | Serum IgG anti-native type II collagen antibodies in rheumatoid arthritis: association wit | 1988 Oct | Serum anti-type II collagen antibodies were measured in 85 rheumatoid arthritis patients before and after treatment with disease modifying drugs. These patients were also serotyped for HLA class II antigens. High anti-type II collagen antibodies (anti-CII) were detected in 35% and 29% of patients at onset and completion of study, respectively. Eighty percent of patients with high anti-CII initially had HLA DR4 (p less than 0.05). There was no correlation of anti-CII levels with severity of disease or response to treatment. | |
| 2147033 | The protective effect of the oral contraceptive pill on rheumatoid arthritis: an overview | 1990 | The oral contraceptive pill (OCP) has been implicated as having a protective effect on the development of rheumatoid arthritis (RA). The results of 12 studies have now been reported and produced differing results and conclusions. Because of the discrepancy in results and the importance of the issue we undertook a review of the studies and performed a meta-analysis. In all, 9 independent studies satisfied the criteria for selection, 6 case-control design and 3 longitudinal. Using standard meta-analysis techniques, the overall pooled odds ratio for all the studies was 0.68 for the crude results (95% CI 0.58-0.78) and 0.73 for the adjusted results (95% CI 0.61-0.85). The graphical odd-man-out method produced a 94% interval of 0.70-0.72. The pooled odds ratio of the case-control studies was lower than for the longitudinal studies. However, subdividing studies by the type of case source produced a pooled odds ratio for studies using hospital-based cases of 0.49 (95% CI 0.39-0.63) which was considerably less than that of studies using population-based cases: 0.95 (0.78-1.16). This difference was unlikely to have explained by bias due to selection of controls. We suggest that OCP use may not have a "protective effect" on the development of RA but may prevent the progression to severe disease by modifying the disease process. | |
| 3716556 | [Our knee joint prostheses with patellar replacement]. | 1986 Mar | In the 13 years since the first Blauth total knee joint replacement was implanted, in August 1972, it has proved highly successful. This is borne out by the results of a prospective long-term study. Out of 488 patients who had been provided with such a prosthesis up to the beginning of 1984, 398, or 82%, were included in the study. Sixty patients had meanwhile died, and 24 could not be contacted. Six prostheses had to be removed. The follow-up quota of the surviving patients corresponded to 94%. The mean duration of observation was 40 months, with a minimum of 12 and a maximum of 144 months. Of the patients, 35% suffered from rheumatoid polyarthritis, and 61% from gonarthrosis. The mean postoperative flexion and extension values were 98-3-0 degrees. About 10% of the patients still claimed to suffer appreciable pain when starting to move and when bearing weight, as compared to approx. 95% preoperatively. Severe complications were 9 deep infections (2.3%) and 5 cases of aseptic loosenings (1.3%). There were no stress fractures or breakages of the prosthesis material in the patients follow up. A retropatellar pain syndrome was found in 8.3% of the patients, i.e., definite pain when standing up, on stairs, or when starting to move. For this reason the original design of the prosthesis was developed further and complemented, inter alia, by an artificial patella. The principal modifications are as follows: -The femoral section was given a concave shape in the sliding bearing of the kneecap and elongated proximally.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 2109613 | Analysis of improvement in individual rheumatoid arthritis patients treated with disease-m | 1990 Apr | A composite index for estimating improvement in individual rheumatoid arthritis (RA) patients during trials of slow-acting, disease-modifying antirheumatic drugs (DMARDs) was developed by analyzing the responses of 130 placebo-treated participants in Cooperative Systematic Studies of Rheumatic Diseases studies. If responses in 4 of 6 selected measures were required for improvement (by greater than or equal to 20% for morning stiffness, Westergren erythrocyte sedimentation rate, joint pain/tenderness score, and joint swelling score, and by greater than or equal to 2 grades on a 5-grade scale, or from grade 2 to grade 1 for patient's and physician's overall assessments of current disease severity), few placebo-treated patients qualified as improved, whereas significantly more DMARD-treated patients demonstrated improvement. The proposed index appears to be useful in estimating the probability that an RA patient will improve if taking a placebo during a DMARD trial, and may be a useful tool for analysis of DMARD studies. | |
| 2735335 | Effect of sucralfate and cimetidine on rheumatoid patients with active gastroduodenal lesi | 1989 Jun 9 | In a pilot study, 26 rheumatoid arthritic patients taking continuous, stable dosage regimens of nonsteroidal anti-inflammatory drugs and with developed gastric and duodenal lesions were administered sucralfate 1 g four times per day (14 patients) or cimetidine 400 mg twice daily (12 patients) in a single-blind regimen for six weeks. Eleven of the patients given sucralfate and eight of the patients taking cimetidine had improved lesion scores. The lesion score of 10 of the 14 patients taking sucralfate and four of the 12 patients taking cimetidine improved by 50 percent or better (not significant). The antrum and body of the gastric mucosa and the mucosa of the duodenum synthesized prostanoids and thromboxane A2, and there was no significant difference in the synthesis of individual prostanoids at entry to the trial in the groups assigned to sucralfate or cimetidine. After six weeks of administration of sucralfate, prostaglandin E2 (PGE2) synthesis by the antrum and body, but not the duodenum, was significantly greater than observed in the biopsy specimens at entry despite continuation of non-steroidal anti-inflammatory drug therapy. After six weeks of cimetidine treatment, no change in PGE2 synthesis was noted in any biopsy specimens when compared with the synthesis at entry. No change in the synthesis of PGF2 alpha, 6-oxo-PGF1 alpha, or thromboxane B2 was noted in gastric or duodenal biopsy specimens in any treatment group. Sucralfate and cimetidine administration resulted in improved gastroduodenal lesion scores in rheumatoid arthritic patients continuing with nonsteroidal anti-inflammatory drug therapy. | |
| 2743718 | Is MCTD a distinct entity? Comparison of clinical and laboratory findings in MCTD, SLE, PS | 1989 Mar | Eighteen patients diagnosed as suffering from MCTD were reexamined during follow-up (mean duration 4.6 years). The clinical features of these patients were compared with those of 19 patients with systemic lupus erythematosus (SLE), 11 with progressive systemic sclerosis (PSS) and 22 with rheumatoid arthritis (RA). Considerable overlapping of abnormal features was found between MCTD and the other syndromes. At the end of the follow-up period, 70 per cent of the cases initially diagnosed as MCTD evolved to a more classical connective tissue disease, i.e., either PSS or SLE. Generally, however, the clinical evolution of the individual MCTD patient was not predictable. Abnormal aortic valve calcifications were found in the MCTD group. Four of the 18 MCTD patients were anti-RNP negative at reexamination. There was a tendency for HLA antigens B7 and B8 to be increased in the MCTD group, but this difference was not statistically significant. Three MCTD patients died before they could be reexamined (two of them from pulmonary hypertension with proliferative endarteritis of the lung vessels and one from septicaemia and multiple cerebral infarctions. | |
| 3961431 | Influence of weather on stiffness and force in patients with rheumatoid arthritis. | 1986 | A simple instrument has been developed for quantitative measurement of stiffness (elasticity) and maximum force of the fingers and was tested in a series of 122 out-patients with RA and 101 healthy controls. Values measured for stiffness were higher in RA patients and were scattered more widely than in controls and the mean values for force in the RA patients were lower than in controls. RA patients with an elevated ESR have significantly less strength than those with low ESR. We evaluated the influence of the time of day and weather (humidity and air temperature on the wards and outside the hospital, barometer pressure) on stiffness and force. In 13 in-patients with definite or classical RA and 12 controls, measurements were performed in the morning and afternoons, over periods of 3 weeks. In RA patients, both stiffness and force increased with outside air humidity (p less than 0.05), confirming the clinical experience that stiffness increases in damp weather. In the controls, force decreased with a higher air humidity on the wards (p = 0.05) and increased with higher barometer pressure (p less than 0.05). In the controls joint stiffness was higher in the morning than in the afternoon (p less than 0.05). In the RA group, rather unexpectedly, the reverse was found (p = 0.06), possibly explained by the time of the day the investigation was done. Only in the controls was a significant increase in force noted during the 3 weeks of investigation (p less than 0.005). No correlation was seen between force and stiffness. No correlation was found between disease activity as expressed in ESR, Hb, Rose titre, ARA grading and stiffness or force. | |
| 3591460 | Water intoxication associated with non-steroidal anti-inflammatory drug therapy. | 1987 | Two cases of rheumatoid arthritis, who developed severe hyponatremia after treatment with non-steroidal anti-inflammatory drugs (NSAID) are presented. Early diagnosis was followed by rapid correction with hypertonic saline. It is suggested that NSAIDs, like piroxicam, diclofenac and indomethacin, may be added to the list of drugs which can induce syndrome of inappropriate antidiuretic hormone (SIADH). | |
| 3636196 | Induction of neutrophil enzyme release by rheumatoid factors: evidence for differences bas | 1986 Aug | Cathepsin G and elastase are two neutrophil proteases capable of degrading the major structural macromolecules of the joint. Evaluation of factors capable of inducing the release of these enzymes is crucial to the understanding of neutrophil-mediated tissue destruction. We have evaluated the effects of IgM rheumatoid factor (RF), as well as monomeric and polymeric forms of IgA RF, on the release of neutrophil elastase, cathepsin G, and the specific granule protein lactoferrin. None of these rheumatoid factors alone was able to induce more lysosomal protein release than media controls. Under conditions used in this study, aggregated human IgG was able to induce slightly more release than media controls. The addition of IgM RF or polymeric IgA RF to the aggregated IgG resulted in release of significantly more lysosomal proteins than aggregates alone. In contrast, monomeric IgA RF, even in the presence of aggregated IgG, was unable to augment enzyme release. These results suggest that differences in the molecular characteristics of RF found in synovial fluid may significantly influence the contribution of RF to tissue injury in rheumatoid arthritis. | |
| 3396226 | Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment | 1988 May | A 51-year-old man developed pemphigus vulgaris, minimal change nephropathy and acute tubular necrosis after 11 months of treatment with penicillamine for rheumatoid arthritis associated with features of Reiter's syndrome. Penicillamine is a polyclonal B lymphocyte activator in animals and precipitates a variety of autoimmune reactions in man. The pathogenesis of minimal change nephropathy is obscure, but our observations support the possibility that autoimmune mechanisms play a role. | |
| 1699041 | [Antinuclear, anticentromere and anti-ScL-70 antibodies in rheumatic diseases]. | 1990 | Methods are described that are used for the titration of antinuclear, anticentromere, and anti-Scl-70 antibodies in systemic scleroderma, systemic lupus erythematosus, and rheumatoid arthritis: indirect immunofluorescence with various antigenic substrates (sections of fresh-frozen rat liver and Hep-2 cell culture), counter-current immunoelectrophoresis, isolation of Scl-70 antigen. Use of Hep-2 cells as a substrate for indirect immunofluorescence was found clinically and diagnostically more effective since it permitted the detection of anticentromere antibodies and anti-Scl-70. Nucleolar, mottled, homogeneous, marginal immunofluorescence types were observed when rat liver sections and Hep-2 cells were used for substrates. Anticentromere antibodies and anti-Scl-70 were isolated significantly more frequently in systemic lupus erythematosus or rheumatoid arthritis. | |
| 2746563 | Treatment of refractory rheumatoid arthritis--the thalidomide experience. | 1989 Feb | In an open study, 17 patients (16 women, 1 man) with refractory or severe rheumatoid arthritis were treated with thalidomide. Two withdrew from the study in the first weeks. Thirteen patients received 531 +/- 63 mg/day of thalidomide for 18.8 +/- 8.8 weeks; in 2 the dose was 300 mg/day during 62 and 65 weeks. Seven patients attained complete remission, 5 partial remission, and the last 3 no improvement at all. Remissions lasted 6 years in 1 patient, 2 years in 3, 1 year in one, and varied between 8 months and 8 weeks in 7. After relapse, 5 patients received a 2nd course of treatment and attained remission again. This lasted 24, 10, and 9 months in 3; two are taking 100 mg/day of thalidomide as a maintenance dose and remain asymptomatic after 36 and 30 months. The side effects were drowsiness, constipation, hard swelling of the lower limbs, erythema of the face and limbs with local pruritus or burning sensation, hair loss, cough, nasal obstruction, fever, and skin and mucosal dryness. In 8 patients there was mild eosinophilia (less than 10%) and in 2 leukopenia. A 33-year-old woman showed amenorrhea up to 2 months after stopping treatment. After a 2nd course of treatment, 2 patients developed peripheral sensory neuropathy, which resolved spontaneously in 6 months. We believe these findings justify controlled trials with this agent. | |
| 2463665 | Recognition by anti-Fab antibodies in rheumatoid arthritis of structure(s) widely distribu | 1988 Nov | Anti-Fab antibodies (aFABA) of restricted clonality and acidic spectrotypes were isolated from the sera of patients with rheumatoid arthritis (RA). These aFABA reacted with multiple populations of pooled human Fab molecules, which had been charge separated by chromatofocusing techniques (CF), indicating that the structures recognized by these aFABA were present on a polyclonal population of Fab molecules. The structures were also widely distributed among the Fab repertoires of normal individuals, as well as individual autologous and heterologous RA patients. Thus, the aFABA did not appear to recognize highly restricted epitope(s), i.e. a private idiotope, limited in its expression to RA individuals. The determinants of the Fab molecules recognized by affinity purified aFABA could be defined by linear and/or conformational structures, depending upon the individual from which the aFABA were isolated. Additionally, some of the affinity purified aFABA also reacted with Fc fragments, suggesting the presence of epibody-like autoantibodies in this population. Lastly, size analysis of the circulating IgG4 aFABA complexes indicated that these autoantibodies were not complexed with intact IgG, but rather with a molecule of 40-60 kDa, further suggesting the potential for these autoantibodies to react with multiple antigens. | |
| 2762074 | Gender effects in pain perception. | 1989 Jun | Studies have shown that women report more pain than men when pain is induced in the laboratory. As sex differences in perceived pain have not been established with clinical or endogenous pain, research was undertaken to compare reported pain of males and females arising from one of three sources. Two groups of adults and one group of children were studied. Analysis indicated no sex differences in reported clinical or endogenous pain for children or adults. | |
| 2711779 | [Ultrastructure of reparation collagen and its relations to residual hyaline joint cartila | 1989 Jan | The development of collagenous fibrils in reparative tissues replacing hyaline cartilage in arthritic joints was investigated by electron microscopy: granulation tissue consists of a loose network of collagenous fibrils, scar tissue is characterized by dense bundles of parallel arranged collagenous fibrils, chondroid tissue that may develop under certain instances is characterized by a network of random orientated fibrils that differ from those of the normal hyaline cartilage by their uniformity. The fibrils of the reparative tissues often exhibited an intense contact with those of the original hyaline cartilage. |