Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2379378 | Unconstrained shoulder arthroplasty. A five-year average follow-up study. | 1990 Aug | A series of 42 total shoulder arthroplasties and four humeral hemiarthroplasties were performed with either the English-McNab or Neer prosthesis. Retrospective follow-up study averaged five years with a three-year minimum. Preoperative diagnoses included rheumatoid arthritis, osteoarthritis, posttraumatic arthritis, rotator cuff arthropathy, avascular necrosis, failed prosthesis, and congenital dislocation. Postoperatively, pain improved in 94% of shoulders, and active range of motion improved an average of 42 degrees in abduction and 47 degrees in forward flexion. Rotator cuff lesions were correlated with poorer postoperative function. Complications developed in four shoulders (9%) and consisted of humeral component protrusions (two shoulders), loosened prosthesis (one shoulder), and unrecognized, preoperative tuberculous infection (one shoulder). Fifteen glenoid components (36%) and six humeral components (13%) developed lucent lines roentgenographically, but only one glenoid component developed migration. | |
| 2877854 | Variables affecting efficacy and toxicity of sulphasalazine in rheumatoid arthritis. A rev | 1986 | Studies of sulphasalazine in rheumatoid arthritis have used largely empirical doses. The available literature suggests that the optimum dose appears to be greater than 40 mg/kg/day. Despite the relationship between dose and efficacy and a good correlation between dose and serum concentrations of sulphasalazine and its metabolites, no relationship has been demonstrated between efficacy and serum concentrations of sulphasalazine or its metabolites, although there is some suggestion that higher concentrations on single dosing are achieved in patients who develop upper gastrointestinal symptoms. Furthermore, acetylator phenotype does not affect efficacy, although upper gastrointestinal symptoms are more common in slow acetylators. | |
| 3499124 | Assessment of disability caused by rheumatic diseases in general practice. | 1987 Aug | At present general practitioners lack a tool for defining the level of disability of individual patients and groups of patients with arthritis. An assessment technique (health assessment questionnaire) developed in the United States is described, and its use in general practice evaluated. Sixty two patients agreed to be visited at home to compare their observed abilities when performing the tasks of the health assessment questionnaire. The health assessment questionnaire (HAQ) is easily understood and takes patients only 10-15 minutes to complete. The numerical scores (range 0-3) for disability obtained on the postal questionnaire are close to the observed scores when patients are visited at home. | |
| 2279842 | The Guildford elbow. | 1990 | A new unconstrained elbow replacement is described and the results of 44 primary and 5 revision operations assessed. A high incidence of pain relief (82%) and functional improvement (73%) was achieved. However 23% of primary replacements later underwent loosening as assessed radiologically and 12% have undergone revision for pain. Minor complications not affecting the final result occurred in 28%. The causes and significance of the complications are analysed. | |
| 3961161 | [Diagnostic imaging potentialities of nuclear resonance tomography. Changes in vertebrae, | 1986 Mar | This is a study of 49 patients with lesions of the spine excluding primary tumors of the spinal cord. All patients were examined by computed tomography and magnetic resonance imaging. Comparing both methods we observed slight diagnostic advantages for magnetic resonance imaging in inflammatory and neoplastic disease. Especially for evaluation of the spinal cord and subarachnoid space MR-imaging is far superior to computed tomography. | |
| 3345232 | Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluron | 1988 Jan | To test the scavenging of reactive oxygen species (ROS), we added synovial fluids from patients with rheumatoid arthritis (RA) and osteoarthritis, as well as hyaluronic acid (HA) and its 2 subcomponents, D-glucuronic acid and N-acetyl-D-glucosamine, to 2 ROS-generating systems, activated neutrophils and xanthine-xanthine oxidase. Synovial fluid from RA patients, HA, and D-glucuronic acid markedly decreased the O2-, H2O2, OH., and chemiluminescence measured in both systems. HA and synovial fluid, which are known to be susceptible to degradation by excessive ROS in RA patients, also seem to play an active role in protecting articular tissues from oxidative damage. | |
| 2597212 | Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexat | 1989 Dec | Retrospective analysis of 23 rheumatoid arthritis patients receiving low-dose methotrexate (MTX) demonstrated an association between the mean corpuscular volume (MCV) and hematologic toxicity. All 6 patients who developed hematologic toxicity were folate deficient, and 4 of 6 had marked macrocytosis. Furthermore, the mean MCV of the patients who developed toxicity was significantly higher than that of the controls without toxicity (P less than 0.02). This difference in MCV was associated with an increased probability of developing toxicity with time (P less than 0.005). These results suggest that sustained elevation in the MCV may be a predictor of impending hematologic toxicity due to folate depletion. | |
| 2088647 | The specificity of antiglobulin autoantibodies in patients with primary Sjögren's syndrom | 1990 Dec | Antiglobulin autoantibodies have already been demonstrated in the sera of patients with primary Sjögren's syndrome (primary SS). In our study, the specificity of primary SS antiglobulins for different regions of IgG molecules was examined by employing both direct binding and competitive inhibition enzyme-linked immunosorbent assay. We found that a considerable amount of total antiglobulins in primary SS was specific for the Fab portion, although the remainder was specific for the Fc portion, namely rheumatoid factor (RF). In contrast, most of the antiglobulins in RA were specific for the Fc portion of IgG. These results indicate that in primary SS, antiglobulins directed against epitopes different from those of RF are produced. These antiglobulins may prove to have a different role in primary SS than that ascribed to RF in RA. | |
| 3774733 | Ileal stricturing after long-term indomethacin treatment. | 1986 Oct | A patient on long-term indomethacin therapy developed intestinal obstruction due to ileal strictures. No other cause apart from indomethacin could be implicated in the pathogenesis of the stricture. | |
| 3658413 | [Arthrodesis following knee arthroplasty]. | 1987 Aug | In 44 failed total arthroplasties of the knee joint, arthrodesis was attempted (1970-1986). The interval between implantation of the total knee arthroplasty and diagnosis of infection was more than 2 years on average. Removal of the arthroplasty and arthrodesis was performed about 1 year later. In 80% of the knees, compression arthrodesis using an AO plate was used 34 times, with solid fusion occurring after 6 months. External fixation was used in 10 patients; rate of solid fusion was only 60%. The reasons for delayed union or failure had to do with reduced bone stock in the metaphysis with poor bone quality, inadequate fixation, and uncontrolled infections. | |
| 1895262 | Comparison of cyclosporine and D-penicillamine for rheumatoid arthritis: a randomized, dou | 1991 Jun | Ninety-two patients with active rheumatoid arthritis (RA) were entered in a randomized double blind study of 24 weeks comparing cyclosporine (initial daily dose 5 mg/kg) with D-penicillamine (initial daily dose 250 mg). The groups were well balanced in baseline characteristics. In the cyclosporine group, 10 patients stopped prematurely, one because of inefficacy. In the D-penicillamine group, 9 patients stopped prematurely, 3 because of inefficacy. The 2 antirheumatic drugs were equally effective in reducing disease activity, except for a significant (p = 0.005) decrease in erythrocyte sedimentation rate with D-penicillamine treatment. We conclude that under the conditions of this trial, cyclosporine can serve as an alternative to D-penicillamine for the treatment of patients with RA. | |
| 1851409 | Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison betwe | 1991 Apr | Deposition of intra-articular calcium pyrophosphate is associated with both aging and arthropathy; increased concentrations of free pyrophosphate (PPi) may contribute to such deposition. Free pyrophosphate and nucleoside triphosphate pyrophosphatase (NTPase) were estimated in synovial fluids from 50 subjects with normal knees and from 44 patients with rheumatoid arthritis, 61 with pyrophosphate arthropathy, and 59 with osteoarthritis. For arthropathic knees clinically assessed inflammation was classified as active or inactive using a summated score of six clinical features. The order of PPi (mumol/l) and NTPase (mumol PPi/30 min/mg protein) was pyrophosphate arthropathy greater than osteoarthritis greater than rheumatoid arthritis (median PPi, NTPase respectively: for pyrophosphate arthropathy 15.9, 0.45; for osteoarthritis 9.3, 0.25; for rheumatoid arthritis 4.4, 0.18), with significant differences between all groups. In pyrophosphate arthropathy both PPi (mumol/l) and NTPase (mumol PPi/30 min/mg protein) were higher than normal (15.9, 0.45 v 8.6, 0.2 respectively), but findings in osteoarthritis did not differ from normal. The inflammatory state of the knee had a distinct but variable effect on synovial fluid findings in rheumatoid arthritis and pyrophosphate arthropathy, but not in osteoarthritis. There was no correlation of either PPi or NTPase with age, or between PPi and NTPase in any group. This study provides in vivo data for synovial fluid PPi and NTPase. It suggests that factors other than PPi need to be considered in a study of crystal associated arthropathy. Clinical inflammation, as well as diagnosis, is important in synovial fluid studies. | |
| 3497428 | [The enthesopathic shoulder]. | 1987 Jun | 61 shoulders of rheumatoid diseases, 23 of ankylosing spondylo-arthritis, 22 of psoriatic rheumatism and 30 of hyperostoses (Forestier's disease) were analysed and compared. There is a very significant difference between rheumatoid disease, on the one hand, and the other diseases, on the other hand. In ankylosing spondylo-arthritis, psoriatic rheumatism and hyperostosis, enthesophytes are observed; it is not the case in rheumatoid disease (unless associated with hyperostosis). The most frequent entesophyte is the one at the acromial insertion of the acromio-coracoid ligament ("bearded acromion"). It is also the easiest to visualise on an AP X-Ray of the shoulders. The association of a bearded acromion and an ulceration of the supero-lateral area of the humeral head (sulcus) is characteristic of spondylo-arthropathies (ankylosing spondylo-arthritis, psoriatic rheumatism) and is not found in hyperostosis. The ulceration of the sulcus is, on the contrary, common to spondylo-arthropathies and rheumatoid disease. This ulceration does not seem to be the sign of an inflammatory enthesopathy but rather a synovitis. | |
| 1851058 | Identification of a myeloperoxidase inhibitor from normal human serum. | 1991 May | An inhibitor of myeloperoxidase (MPO) has been identified in normal human serum. Initial experiments confirmed that high levels of MPO inhibitory activity are present in sera and that the inhibitor did not act by interfering with the assay. Purification of the inhibitor activity by salt precipitation followed by ion exchange and affinity chromatography revealed the presence of a protein of 150 kD. The purified inhibitory activity displayed dose and time dependency and was not associated with IgG or IgA. It is considered that human serum contains an inhibitor of extracellular MPO capable of protecting against hypohalous acid release in host tissues and that if inhibitor levels are reduced such protection may fail. | |
| 3616446 | [Magnetic resonance imaging in rheumatology]. | 1986 Nov | The authors report their experience with magnetic resonance imaging in rheumatology, established on more than 250 examinations. The method seems interesting for the study of discal and somatic spine diseases, and especially for the evaluation of tumor extension, the diagnosis of herniated disc, the diagnosis of spondylodiscitis, the exploration of the cervico-occipital joint. As compared to tomodensitometry, this method presents at the same time advantages and drawbacks. Peripherally, magnetic resonance imaging is useful for the exploration of bony tumors and evaluation of their extension. It gives excellent images of the knees and the hips where it seems to improve the results of tomodensitometry and bony scintigraphy in the diagnosis of osteonecrosis. It is likely that advances will broaden the scope of the indications and capabilities of this method. | |
| 1862248 | Botanical lipids: potential role in modulation of immunologic responses and inflammatory r | 1991 May | Enrichment of cells with fatty acids of particular botanical lipids alters cell function in vitro (for example, suppression of human synovial cell and T lymphocyte proliferation) in a manner that suggests that administration of these botanical lipids may be a useful therapeutic strategy for patients with diseases characterized by disordered immune responses and chronic inflammation. Treatment of animal models with certain plant seed oils suppresses inflammation and joint tissue injury. Controlled trials in patients with rheumatoid arthritis are in an early stage, but offer encouragement. The mechanisms whereby these novel lipids influence host defense include alteration of arachidonic acid oxygenation products and direct effects on cells independent of fatty acid metabolism. | |
| 3365894 | Metatarsal head resection for rheumatoid deformities of the forefoot. | 1988 May | Thirty-five feet in 21 patients, who had had metatarsal head resection for painful rheumatoid forefoot deformities, were analyzed retrospectively. All patients but one were allowed to ambulate 48 hours after surgery. The follow-up period averaged 29 months. A grading system was devised to assess the clinical results based upon pain relief, capacity to ambulate, shoe wear, cosmesis, and use of walking aids. Using this system, the results were 46% excellent, 34% good, 17% fair, and 3% poor. One patient developed a superficial wound infection, which healed uneventfully. Bony impingement was observed on follow-up roentgenograms of 67% of the resectional arthroplasties. This finding was generally asymptomatic, and it did not correlate with the clinical outcome. Smooth wire fixation was used in some of the feet, but it did not improve the results either roentgenographically or clinically. | |
| 3245287 | [Is high-density polyethylene suitable as an implant material in cement-free anchoring of | 1988 Dec | Firmly attached screw-in polyethylene acetabula which had been implanted for between 16 and 54 months were explanted after autopsies and subjected to macroscopic, radiologic and histologic examination. Metaplasias were seen around the threads and on the floor of the acetabulum. Their tendency to ossify represents an attempt at secondary stabilization. Due to the low stability of the polyethylene this causes increased wear on the floor of the acetabulum. The small defects in the polyethylene found in the threads, resembling damage done by mice, may be a sign of biodegradation. In view of the tissue reactions pointed out, the material stability of the polyethylene needs to be improved or implantation must be restricted to a very limited range of indications. | |
| 1820660 | "Yellow nail syndrome" and rheumatoid arthritis. | 1991 Dec | A nail dystrophy characterized by the slow growth of nails and their yellowish discoloration, the so-called yellow nail syndrome (YNS), has been associated with various conditions including rheumatoid arthritis (RA). We reviewed the histories of RA patients reported in the literature and our own cases. Most of the RA patients with YNS had been treated with the anti-rheumatic agents D-penicillamine and bucillamine. In non-treated patients, spontaneous YNS was very rare. However, pulmonary diseases, edema and other systemic complications were frequently observed in both drug-induced and spontaneous YNS associated with RA. Although the nail changes and systemic complications are probably due to different causes in drug-induced YNS, a careful search for systemic complications are necessary in patients who develop nail changes. The exact mechanism of nail growth retardation is not understood in patients with YNS, including those with drug-induced YNS. The nail changes in the latter were not associated with deficiencies of inorganic elements in either nails or sera. | |
| 2310221 | Immunogenetic heterogeneity of seronegative rheumatoid arthritis and the antiperinuclear f | 1990 Jan | HLA typing was carried out in 132 patients with rheumatoid arthritis (RA) with long term follow up, and special attention was focused on rheumatoid factor negative patients. The patients were divided into four groups: 55 patients with a seropositive RA and a positive antiperinuclear factor (group A); 39 seropositive patients but a negative antiperinuclear factor (group B); 14 patients consistently seronegative for 3-28 years (mean 11.8 years) but positive for antiperinuclear factor (group C); patients consistently negative for 3-28 years (mean 11.8) and also negative for antiperinuclear factor (group D). The prevalence of HLA-DR4 was 31/55 (56%), 29/39 (74%), 10/14 (71%), and 9/24 (37%) for groups A, B, C, and D respectively, and in all groups was significantly higher than in 277 healthy controls (55/277, 20%). No significant difference was found between seropositive (groups A and B) and seronegative (groups C and D) patients, but groups A, B, and C had higher prevalences than group D. It is concluded that in seronegative RA HLA-DR4 is preferentially associated with the antiperinuclear factor positive group. |