Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1726907 | Vitiligo in autoimmune thyroid disease. | 1991 May | The authors studied the association between vitiligo and autoimmune thyroid disease. Vitiligo was found in 20 of 293 patients with autoimmune thyroid disease (6.83%), 2 out of 227 patients with nonautoimmune thyroid disease (0.88%), and 3 out of 386 control group (0.78%). These results showed that vitiligo is closely associated with autoimmune thyroid disease (chi 2 = 24.33, p < 0.0001), but not with nonautoimmune thyroid disease. Prevalence of vitiligo in nonautoimmune thyroid disease was not different from that in control. Vitiligo in autoimmune thyroid disease was most frequently found on dorsum hands and forearms, and usually preceded the onset of thyroid disease. Four out of twenty patients with vitiligo associated autoimmune thyroid disease had another presumed autoimmune disease, that is, alopecia areata, alopecia totalis, and rheumatoid arthritis. These findings suggested that autoimmunity plays an important role in the pathogenesis of vitiligo. | |
| 1648616 | Discrimination of antineutrophil antibodies from antinuclear antibodies using immunofluore | 1991 Apr | Sera of 209 patients with rheumatic disease demonstrated 3 patterns of immunofluorescence (IF) on ethanol fixed neutrophils (PMN) and a promyelocytic cell line (HL60): (1) cytoplasmic on PMN, negative on HL60 cells, (2) nuclear or perinuclear on PMN, negative on HL60 and (3) nuclear or perinuclear on both PMN and HL60 cells. Pattern 1 was observed in sera of patients with Wegener's granulomatosis, but also in several patients with other rheumatic diseases. Pattern 2 was observed in sera of patients with systemic vasculitis or rheumatoid arthritis (RA). Antimyeloperoxidase activity was detected in sera from patients with systemic vasculitis that produced Pattern 2, but rarely in sera of patients with RA that produced the same IF pattern. Pattern 3 was observed in sera that contained antinuclear antibodies as detected by IF on HEp-2 cells. | |
| 2018723 | The nail apparatus in collagen disorders. | 1991 Mar | Patients with collagen disorders may have a broad spectrum of nail changes. This article reviews the modifications of the nail apparatus that can be observed in the following diseases: systemic sclerosis, systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease, rheumatoid arthritis, periarteritis nodosa, and Wegener granulomatosis. In all collagen diseases, the proximal nail fold is the most important site of alterations, and a careful inspection of this nail constituent is an essential part of the patient's routine clinical evaluation. Erythema and telangiectasia associated with visualization of the capillary loops are frequent findings; nail fold capillary hemorrhages and focal necrosis are also observed. The nail fold capillary microscopy abnormalities and the special nail changes that can be observed and characterize each collagen disorder are described. A careful clinical examination of the nail and a capillary microscopy study of the prossimal nail fold may, therefore, be decisive for the diagnosis of the collagen disorders. In fact, the nail unit alterations may give a clue that should not be overlooked. | |
| 2159859 | Release of elastolytic activity from human monocytes and granulocytes in vitro by immune c | 1990 Mar | Elastase from phagocytes are neutral proteolytic enzymes and potent destructors of elastic fibres, proteoglycan and collagen. Using soluble 3H-elastin as substrate in a cell culture assay we examined the ability of live, adherent human blood neutrophils and monocytes to release elastolytic activity following immune complex (IC) stimulation. While monocytes increased their elastolysis 2 1/2 times in response to IC (p less than 0.01), neutrophils did not but released lactoferrin and produced superoxide. Both cell types could be stimulated by phorbol myristate acetate (PMA) to increase elastolysis (p less than 0.02) and produce superoxide. Thus, when in contact with the elastin substrate, the in vitro response of monocytes and neutrophils to IC differed with respect to elastolytic release. These findings might be of interest in the understanding of cartilage destruction in immunocomplex-mediated diseases such as rheumatoid arthritis. | |
| 2140640 | [Prostaglandins in bone and cartilage metabolism]. | 1990 Mar | Prostaglandins induce very probably the local intercellular communication and regulate the metabolism of bone and cartilage. They are supposed to be local mediators of mechanical stress, electric phenomena as well as of hormonal control mechanisms in cytobiologic and cytochemical reactions within the skeletal system. In-vitro prostaglandins act as potent bone and cartilage resorbing agents. In-vivo they also promote the synthesis of bone in a way that is not known as yet. Experimental investigations proved their influence on inflammatory processes, and, above all on the bone destruction in the pathogenesis of rheumatoid arthritis and osteomyelitis. It is the aim of the following review to elucidate the function and metabolism of prostaglandins with regard to their clinical importance and, particularly, to orthopaedic diseases. | |
| 1968112 | Cutaneous vasculitis: approach to diagnosis and systemic associations. | 1990 Feb | The starting point in the evaluation of vasculitis is the clinical examination. The character and location of the primary lesions determine the type of biopsy specimens and additional tests needed to classify vasculitis. The most common causes of cutaneous vasculitis are drug reactions, infectious diseases, reactions to inflammatory diseases such as rheumatoid arthritis or inflammatory bowel disease, or association with malignant disease, especially lymphoproliferative disorders. Direct immunofluorescent techniques and leukocyte monoclonal antibody studies are useful for the diagnosis of selected cases of vasculitis. The clinical and histopathologic data help delineate an approach for further investigation of potentially associated systemic disorders or underlying causes. Although some cases of cutaneous vasculitis are not associated with systemic disorders, this possibility should never be assumed but considered only as a diagnosis of exclusion after careful examination of each patient. | |
| 2151080 | Injury to gastric mucosa due to cortisonoid therapy. | 1990 | Drawing on their own experience and reports in literature the present authors analyze the problem of the incidence and origin of alterations on the gastric mucosa (steroid ulcer) in the course of cortisonoid therapy. Over the period of 5 years, 576 patients were studied, 29 (5.03%) of which were found to have developed a lesion of the gastric mucosa. Patients with rheumatoid arthritis and collagenoses were the most frequent of these. This is followed by an analysis of the mechanism of origin and the peculiarities of this lesion as compared with the picture of the classical ulcer. Apart from medicamentous therapeutic procedures in the treatment of steroid ulcers, local application of a HeNe laser radiation has come to be used recently in the healing of a chronic gastroduodenal ulcer. Despite all the vast experience and more accurate knowledge of the drawbacks cortisonoid therapy brings along, the steroid ulcer still represents a feared and not quite rare complication of glucocorticoid therapy. | |
| 2560763 | Secondary lymphomas: a review on lymphoproliferative diseases arising in immunocompromised | 1989 Nov | This paper reviews the major information on lymphoproliferative diseases developing in primary and acquired immunodeficiencies, in organ allograft recipients, and in different diseases with immune impairment such as rheumatoid arthritis, angioimmunoblastic lymphadenopathy, and Hodgkin's disease (secondary lymphomas). The hypothetical role of Epstein-Barr virus (EBV) in the pathogenesis of lymphoproliferative diseases in immunocompromised hosts has come from the examination of lymphoma cells or tissues for Epstein-Barr nuclear antigen (EBNA), or carriage of the viral genome, and will be extensively reviewed. The characteristics and the prognosis of high-grade lymphomas developing in the acquired immunodeficiency disease (AIDS) will be analyzed, together with their pathogenetic mechanisms, with particular emphasis on the constant presence in the lymphoma cells (mostly of Burkitt-type) of the c-myc oncogene rearrangement and activation. The principal methods of study of secondary lymphomas and major attempts at therapy will reviewed as well. | |
| 2754191 | Extensor carpi ulnaris and flexor carpi ulnaris tenodesis of the unstable distal ulna. | 1989 Jul | A procedure for stabilizing the distal ulna using the extensor carpi ulnaris and flexor carpi ulnaris is described. Seven patients who had sustained posttraumatic distal ulnar dorsal instability and articular degeneration and one patient with instability caused by rheumatoid arthritis were operated on. All eight obtained stable ulnae with mean motion of 62 degrees of supination and 86 degrees of pronation (mean increase of 32 degrees of supination and 43 degrees of pronation). Follow-up averaged 28 months (range, 18 to 63 months). The tenodesis, using a weave of a distally-based slip of flexor carpi ulnaris and a proximally-based slip of extensor carpi ulnaris combined with a Darrach procedure, is a reliable, reproducible salvage procedure for stabilizing the degenerated distal radioulnar joint and for salvaging the symptomatic unstable ulna after excessive distal ulna resection. | |
| 3037083 | Decreased hydroxyl radical generation from polymorphonuclear leucocytes in the presence of | 1987 Feb | The effect of D-penicillamine (DP) and thiopronine on the generation of reactive oxygen species (ROS) both by stimulated polymorphonuclear leucocytes (PMNs) and in a cell-free, xanthine-xanthine oxidase system was investigated. Both drugs significantly reduced hydroxyl radical (OH.) generation in the PMN system, however, increasing trends of OH. levels were noticed in a cell-free ROS generating system. Although the opposing effects on ROS levels were verified, these two agents showed a similar behaviour presumably due to their structural similarity. The properties of these agents that affect ROS levels may contribute to their beneficial and toxic actions in inflammatory as well as immunoregulatory processes of rheumatoid arthritis (RA). | |
| 3550988 | [Cyclosporin and autoimmune diseases. 2: Human autoimmune diseases]. | 1987 Jan | The effectiveness of cyclosporin against human auto-immune diseases has been well established in uveitis, rheumatoid arthritis and insulin-dependent diabetes. No firm conclusion can be drawn from trials conducted in other diseases, since the results are discordant or based on an insufficient number of subjects. In view of the side-effects, and notably the risk of nephrotoxicity, of the drug, the blood levels of cyclosporine must be measured and the patient's renal function evaluated at regular intervals. For the time being, these risks reduce the prescription of cyclosporin to the severe forms of autoimmune diseases, i.e. those which resist conventional corticosteroid therapy. Things are different with diabetes, since cyclosporin is the only immunosuppressant which has proved effective in inducing remissions. But whether such remissions can be maintained in the long term remains uncertain, and this type of treatment is still limited to therapeutic trials. | |
| 2872560 | Temporal bone showing polyarteritis nodosa, otosclerosis, and occult neuroma. | 1986 Jun | The clinical and general histopathologic manifestations of systemic vasculitis of the polyarteritis nodosa type are well known. Although hearing loss associated with polyarteritis nodosa has been reported, only two temporal bone studies are available. The findings in a 60-year-old man with well-documented hearing loss who had rheumatoid arthritis, polyarteritis nodosa, and otosclerosis are presented. Polyarteritis nodosa extensively involved the subarcuate arteries and arteries of the facial canal. There were decreased nerve fibers to and sensory cells in the crista of the semicircular canals and macula of the utricle and saccule. Focal and diffuse atrophy of the stria vascularis and decreased cellularity in the spiral prominence and ligament were present. There was a loss of outer hair cells. Otosclerosis involved the left and right oval window niches (bilateral stapedectomy had been performed). There was a small Antoni type A neuroma of the superior division of the vestibular nerve on the left. | |
| 3015291 | Difficult acetabular revision. A preliminary report. | 1986 Spring | Thirteen patients (14 hips) underwent revision from conventional cemented total hip arthroplasty to uncemented acetabular threaded screw-in components and cementless femoral press-fit stems by means of the Autophor, Biofit, and Ti-Thread designs. The patients suffered from all forms of primary hip disease except rheumatoid arthritis; their average age was 34 years. The average preoperative Harris hip score was 39.4; the average postoperative score was 71.2 at six months, 90.6 at one year, and 91.6 at two years. Complications included two femoral shaft fractures, one femoral nerve palsy, and one dislocation. No signs have been observed of loosening or migration as of an early (6-24 months) follow-up. | |
| 1943879 | The macrophage theory of depression. | 1991 Aug | Excessive secretion of macrophage monokines is proposed as the cause of depression. Monokines when given to volunteers can produce the symptoms necessary for the Diagnostic and Statistical Manual of Mental Disorders, Third Edition Revised (DSM-III-R) diagnosis of major depressive episode. Interleukin-1 (IL-1) can provoke the hormone abnormalities linked with depression. This theory provides an explanation for the significant association of depression with coronary heart disease, rheumatoid arthritis, stroke and other diseases where macrophage activation occurs. The 3:1 female/male incidence of depression ratio is accounted for by estrogen's ability to activate macrophages. The extraordinary low rate of depression in Japan is consistent with the suppressive effect of eicosapentanoic acid on macrophages. Fish oil is proposed as a prophylaxis against depression and omega-6 fat as a promoter. Infection, tissue damage, respiratory allergies and antigens found in food are some of the possible causes of macrophage activation triggering depression. | |
| 1999685 | The history of nitrite in human nutrition: a contribution from German cookery books. | 1991 | In order to settle the question of when saltpetre (nitrate) came in use as an additive to human food, a number of historic cookery books from Germany and Austria were reviewed. Obviously, the change from vegetable dyes to saltpetre for the coloring or color preservation, respectively, of meat occurred between 1600 and 1750, probably near 1700. The addition of sugar which favours the reduction of nitrate to the active agent nitrite became common practice during the 19th century. Thus some historic parallels to the appearance of colorectal cancer, multiple sclerosis and rheumatoid arthritis in the medical literature became apparent. | |
| 2263276 | [A patient with acute hydroxychloroquine poisoning; recommendation for treatment]. | 1990 Dec 15 | We treated a 30-year-old man for whom Plaquenil (hydroxychloroquine) had been prescribed for rheumatoid arthritis, and who had taken 4 g orally to end his life. Symptoms of severe intoxication due to (hydroxy)chloroquine are rapid onset of hypoventilation, cardiovascular collapse with bradycardia, peripheral vasodilation, arrhythmias and convulsions. The lethal dose of chloroquine has been estimated at 3-5 g in adults and at 0.75-I g in young children. Acute intoxication should be treated with aspiration of gastric contents, artificial ventilation in case of hypoventilation and intravenous or intratracheal dopamine, noradrenaline or adrenaline in case of cardiovascular depression and peripheral vasodilation. Arrhythmias and convulsions should be treated symptomatically. The patient in our case survived the intoxication and is now under psychiatric treatment. | |
| 2338362 | Development and evaluation of a rapid, semi-automatic micro-method for CH50 estimation usi | 1990 Apr | Established methods for the estimation of serum complement are often unsatisfactory. Problems include complex mathematical and/or technical manipulations, lack of objectivity, and poor sensitivity. Here we present an assay that is rapid, sensitive, quantitative, simple and semi-automatic by using an 'ELISA' reader to estimate released haemoglobin. It compares very favourable with a more manual, old established method. We have used this new method to establish a normal range, investigate serum storage conditions, and demonstrate that the sensitised sheep red blood cells are suitable targets after overnight storage at 4 degrees C. Furthermore we confirm that serum from patients with systemic lupus erythematosus or Sjögren's syndrome frequently has reduced levels of CH50. Patients with rheumatoid arthritis, scleroderma, Bechet's disease or arteritis have a mean CH50 within the normal range. | |
| 2210567 | Cyanoacrylate glue in the treatment of corneal ulcerations. | 1990 | The application of tissue adhesives to treat different corneal diseases has been used extensively in recent years. Owing to the widespread application, it has been possible to establish the advantages and disadvantages of this method of treatment. Keeping in mind the disadvantages (primarily the toxicity of cyanoacrylate glue for the corneal endothelium and lens when it comes into direct contact with these structures), the application of cyanoacrylate glue was restricted to the treatment of progressive corneal ulcerations where the risk of corneal perforation was recognized. This method of treatment was applied in 30 patients with corneal melting in dry eye associated with rheumatoid arthritis (12), trophic postherpetic ulcerations of the cornea (9), chemical corneal burns (7), neurotrophic corneal ulceration (1) and Mooren's ulcer (1). The defect healed and anterior corneal surface epithelization occurred in 73.33% of patients in contrast to the additional treatment, most commonly penetrating keratoplasty, required in the remaining patients (26.67%). | |
| 2803203 | [Intermediate term results following supra-tubercular corrective osteotomy of the head of | 1989 Aug | In the operative therapy of gonarthrosis the supratubercular osteotomy of tibia head has a solid position. In the present work the results of subtractive and additive intraligamentous correction osteotomy with following fixation in plaster dressing on the orthopaedic clinic of the district hospital Aue will be explained. In the period from 1982-1987 35 supratubercular tibia head correction osteotomies in 32 patients with unicondylar gonarthroses were carried out. These were examined on an average of 2.8 years (0.8-5.4 years) post operative. The supratubercular correction osteotomies were composed of 27 valgus and 8 varus operations in corresponding axis deviation. 85 per cent of all examinated patients were satisfied and very satisfied with the operation results. This justifies the further execution of the named operative method. Among the 15 per cent of the unsatisfactory operation results were mainly gonarthroses of higher severities and rheumatoid arthritis. The results shows, that in the last cases the indication is stronger to make and the possible unilaterale or totale arthroplasty--especially in higher living age--are take into consideration. | |
| 2652986 | Do nonsteroidal anti-inflammatory drugs cause lower gastrointestinal bleeding? A brief rev | 1989 Apr | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been available for over a decade. Their prime usage has been for the alleviation of pain in rheumatoid arthritis, osteoarthritis, and other painful musculoskeletal and organic syndromes. Physicians and patients have accepted that these drugs can cause irritation of the gastric mucosa and even lead to ulceration and bleeding. While these effects on the gastric mucosa are well researched and documented, the effects of NSAIDs on the lower bowel are not sufficiently documented, and it is presumed that these agents do not cause any lower gastrointestinal bleeding. Hence, even in the presence of lower gastrointestinal disease, these agents are prescribed by physicians. Because these agents are capable of causing serious or life-threatening disease, a brief review of the effects of NSAIDs on the lower gastrointestinal tract is presented. |