Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2706821 | False-positive seroreactions for syphilis as a harbinger of disease revisited. | 1989 Jan | A cohort of 59 initially healthy subjects with chronic false-positive seroreactions for syphilis was followed for 3 to 19 years (mean 13 years) by data linkage to computerized population registry and to national hospital discharge registry using a unique personal identification number. One subject had moved abroad, but all others were known to be alive at the end of the follow-up period. Four subjects developed systemic lupus erythematosus and two developed rheumatoid arthritis. One subject was admitted to hospital because of protracted substernal pain, but a myocardial infarction could not be verified. This case corresponds to the expected number of cardiovascular events in the cohort. A chronic false positive seroreaction for syphilis was calculated to represent a hundred-fold risk for the development of systemic lupus, but such seroreactions did not seem to predict an excess of cardiovascular diseases. | |
| 2487744 | [Bacteroides distasonis meningitis]. | 1989 | A 50 year old woman while undergoing severe treatment for rheumatoid arthritis, developed anaerobic meningitis. The cerebrospinal fluid (CSF) sample was transported and cultivated aerobically and anaerobically. After 48 h at 37 degrees C the anaerobically incubated plate, the enriched fluid thioglycollate medium and the anaerobic culture medium yielded luxuriant growth of an anaerobic Gram negative bacillum. The biochemical and antimicrobial susceptibility patterns were consistent with those for Bacteroides distasonis. Most of the strains of the 5 species included in the Bacteroides fragilis group (B. fragilis, B. vulgatus, B. ovatus, B. thetaiotaomicron and B. distasonis) are resistant to penicillins, cephalosporins of first generation and aminoglycosides. Anaerobic polyresistant flora from an intraabdominal focus (chronic cholecystitis) might have been selected by treatment with gentamicin and cephalotin, and proliferated into meningeal dissemination. It is important that CSF from immunocompromised patients with acute or chronic pulmonary, intraabdominal or cranium-facial infectious processes be transported and cultured in aerobic and anaerobic conditions. These patients must be treated with an initial therapeutic scheme that includes an effective antibiotic for the anaerobic microorganism that may be involved. | |
| 3044152 | Use of avidin-biotin-glucose oxidase complex to detect antimalarial antibody in serum by l | 1988 Aug | An immunohistochemical assay was developed combining an avidin-biotin-glucose oxidase complex procedure (ABC-GO) with light microscopy to detect specific antibody against Plasmodium falciparum. Thin blood films were prepared from culture material of P. falciparum and fixed with acetone. Antibody was detected by successive incubations with test serum, biotinylated goat antihuman antibody, avidin-biotin-glucose oxidase complex, and glucose oxidase substrate. In the presence of reactive serum, a blue precipitate formed on the parasites and could be visually observed with a 40x objective. Sera from patients with single infections for P. vivax or P. ovale were unreactive. No cross-reactivity was observed with sera from patients with rheumatoid arthritis, filariasis, amebiasis, schistosomiasis, dengue, scrub typhus, leptospirosis, or toxoplasmosis. The sensitivity of ABC-GO is comparable to that of the indirect fluorescent antibody test. | |
| 2845079 | Effect of metal containing compounds on superoxide release from phorbol myristate acetate | 1988 Jul | A variety of metal containing compounds were examined for their ability to inhibit the respiratory burst of murine peritoneal macrophages. Auranofin (AF), a gold containing complex used in the treatment of rheumatoid arthritis, is a potent inhibitor of the macrophage respiratory burst. Ten rhodium, iridium, osmium and ruthenium containing complexes were inactive in inhibiting superoxide production. The only active nongold organometallic complex was spirogermanium which had an equivalent IC50 for activity as AF. The inhibitory activity of AF, but not spirogermanium, was reduced in the presence of the sulfhydryl reducing agent dithiothreitol. This suggests that interactions other than those with sulfhydryl groups may be involved in the action of spirogermanium. | |
| 2471999 | The importance of CD5-positive B cells in nonorgan-specific autoimmune diseases. | 1988 | CD5, the human counterpart of Ly-1 molecules in the mouse, are detectable but weakly expressed on a minute fraction of circulating B cells. The number of CD5-expressing B cells is increased in patients with rheumatoid arthritis or primary Sjögren's syndrome. These cells are similar to those leading to chronic lymphocytic leukemia (they may be induced to produce multispecific autoantibodies). Multispecific autoantibodies have also been described in the early B cell repertoire. | |
| 2460998 | [Complex radionuclide diagnosis of tumor lesions of the bones]. | 1988 | A complex examination of 320 patients with breast tumors of varying degree of advancement was carried out. Also, the data on examination of 20 cases of fibrous-cystic mastopathy and 40 healthy females were analysed. Similar studies were conducted in 20 cases of acute and chronic osteomyelitis, 14--tuberculosis of bones and joints, 63--rheumatoid arthritis and 36--Bekhterev's disease. Pyrphotech, Tc99m; pyrophosphate, Tc99m and diphosphonate Tc99m were used in carrying out scintigraphic examination. Parathyrin, prolactin, carcinoembryonic antigen (CEA), alpha-fetoprotein and ferritin were assayed in patients' blood serum. Tumor dissemination to bones was matched by a significant rise in CEA and prolactin levels. However, these parameters were normal in patients with non-tumor skeletal pathology. No significant rise in ferritin and alpha-fetoprotein were recorded in all patients. The specificity of the said complex examination, including osteoscintigraphy and blood plasma parathyrin assays in breast cancer patients, was 79%. | |
| 3744136 | [Animal experiment studies on the topic of regeneration of the synovial membrane following | 1986 Jul | Tenosynovectomy in patients with rheumatoid arthritis is performed most commonly in the region of the wrist and the ankle. Complications with regard to gliding ability and rupture of the flexor tendons are feared in the so-called no-man's land. The goal of this study was the morphologic examination of the regeneration of synovial membrane in flexor tendons after radical tenosynovectomy. Chronological and qualitative changes of the membrane as well as possible negative effects on the tendon such as adhesions and trophic disturbances were of interest. Synovectomies of flexor tendons were performed in 27 Albino rabbits in the region of the wrist. The synovium and the flexor tendons were histologically examined with light microscope and with scanning electron microscope at intervals between two days and 19 weeks. According to our results a new, fully functioning synovial membrane develops after four weeks. The flexor tendons show no pathologic changes and no adhesions as long as the visceral sheet around the flexor tendon remains undamaged. | |
| 2423923 | [Advantages and limitations of chemicomorphological study of pleural fluid]. | 1986 Apr 21 | A chemical-physical and morphological examination of 109 pleural samples taken from 66 patients showed that the most reliable laboratory tests for discriminating between an exudate and transudate were specific gravity, total effusion protein content and the effusion/serum protein ratio, while LDH and cell number seem less important. In the differential diagnosis of pleuritis, pleural fluid amylase assays are important only if certain well-defined diseases are suspected (particularly pancreatitis). In this case the assay is irreplaceable. Glucose assay may be carried out for a wider range of complaints although a review of the literature shows it to be always below 30 mg, particularly in cases of rheumatoid arthritis. A cytological examination offers a pathognomonic guide in the case of tumours and as a back-up to other checks for many other complaints. | |
| 3764762 | [Kidney lesion in multiple myeloma]. | 1986 | The authors have analysed the difficulties of delayed diagnosis of multiple myeloma (MM) with renal lesion in 27 patients admitted to the clinic of therapy and occupational diseases of the I.M. Sechenov First Moscow Medical Institute over the last 10 years. Before admission to the clinic MM was presumably diagnosed in 6 patients only, 17 patients were referred to the clinic with the diagnosis of this or that renal disease, 3 with the diagnosis of hypertension and 1 with rheumatoid arthritis. The main symptom in all the patients was proteinuria (isolated or combined with raised ESR and/or anemia in scanty urinary sediment). Macrohematuria was occasionally noted in one patient at the onset of the disease, and in another patient the onset of MM was marked by tubulopathy. The correct recognition of MM with renal lesion was rare which was due to a variety of initial symptoms (sometimes they were poorly expressed) and underestimation of the diagnostic importance of the combination of proteinuria with raised ESR and/or anemia. | |
| 1752889 | Inflammatory abdominal aortic aneurysms: does an early stage exist? | 1991 Nov | Inflammatory aneurysms are characterised by a peculiar clinical (i.e. abdominal-lumbar pain, weight loss and increased ESR) and morphological picture (whitish wall, adhesion to the surrounding organs and thickness greater than 0.5 cm). The lymphomonoplasmacellular infiltrate and the interstitial deposits of collagen define the histological picture of these lesions. The authors describe three abdominal aortic aneurysms macroscopically characterised by parietal edema, hyperemia and hypertrophy of the preaortic lymphnodes. Histological study revealed a conspicuous and widespread lymphomonoplasmacellular infiltrate and interstitial edema. The abdominal-lumbar pain, the increase in ESR and the reactive C protein defined the clinical and laboratory aspects. Serological tests for syphilis, rheumatoid arthritis and lupus erythematosis were negative. The question which arises from these observations is whether these forms represent separate entities or an early stage in the evolution of inflammatory abdominal aortic aneurysms with fibrosis. | |
| 1792530 | Mortality, disability and changes in occupation among aging municipal employees. | 1991 | During a four-year follow-up period the indicators of work load, individual factors, and stress reactions predicting mortality, disability, and change of occupation were studied. In 1981, 6257 active workers aged 44-58 years answered a questionnaire. The study was repeated in 1985 when 1% of the subjects had died, 9% had become disabled, and 5% had changed their occupation. These changes had occurred the most often in occupations which included muscular work, poor work postures, and a poor physical environment. The highest mortality rate was observed for the male installation and auxiliary workers who had reported the presence of cardiovascular, but no musculoskeletal, disease four years earlier. The highest disability rate was well predicted by a poor index of work ability. Major diseases leading to disability included malignant tumor, coronary artery disease, congestive heart failure, rheumatoid arthritis, bronchitis or bronchial asthma, and mental disease. Work-related stress reactions were associated with both mortality and disability. | |
| 1720975 | [Sarcoid synovitis. A case report of localization at the level of the flexor tendons of th | 1991 | Sarcoidosis without bone involvement or sarcoid dactylitis, is a very unusual cause of flexor synovitis. Our reported patient initially presented with chronic arthralgia of the knees and ankles. The initial diagnosis of rheumatoid arthritis was incorrect. A surgical flexor synovectomy was performed to release painful compression of the median nerve due to the synovitis. The correct diagnosis was suggested by the histopathological examination showing noncaseating epithelioid granulomas. The diagnosis was confirmed by the association of a negative tuberculin test and raised angiotensin converting enzyme. No recurrence of synovitis occurred after surgical excision and colchicine therapy but arthralgia persisted. | |
| 2273493 | Effects of prostaglandin E1 on collagen diseases with high levels of circulating immune co | 1990 Nov | Prostaglandin E1 (PGE1) was administered to 4 patients with collagen diseases presenting with high levels of circulating immune complexes (CIC) in sera. Our study patients had progressive systemic sclerosis, systemic lupus erythematosus, polyarteritis nodosa, and rheumatoid arthritis. In all 4 patients, CIC levels significantly decreased after administration of PGE1 by continuous infusion at 10/ng/kg/min via central venous catheter for 72 h. In addition, the skin ulcer in a patient with PSS healed completely, and the finger necrosis in a patient with RA improved. These results suggest that PGE1 given by continuous venous infusion is effective in reducing CIC, in addition to improving peripheral vascular disorders. | |
| 2233113 | [Is there a rheumatic fever?]. | 1990 May | In 1988, 11 patients with a suspicion to rheumatic fever (RF) or acute polyarthritis were admitted to the Department of Internal Medicine, University Hospital, "Dr. M. Stojanović". Eight patients have been extensively treated together with a physiatrist, while one of them on an outpatient basis. Follow-up has been from 3 to 9 months. Rheumatic fever was diagnosed with a certainty in only one patient. Three have had the diagnoses of Reiter's syndrome and individually, of infectional, ankylosing and rheumatoid arthritis. One patient is still followed up because of the symptomatic diagnosis of partially cured oligoarthritis or recurrent RF. The numerical relation of established diagnoses for the followed up patients has been in accordance with the decrease in incidence of RF both in our country and the world some decades ago. The possible causes of frequent diagnoses of RF in adults and the necessity of careful evaluation of clinical and laboratory parameters and the need to follow-up unclear polyarthritis even when the patients are not hospitalized, until the definite diagnosis has not been made is stressed in this paper. Therefore, the administration of corticosteroids has to be avoided in these patients, except in special cases. | |
| 2183525 | [Generalized tendomyopathy. I: Clinical aspects, follow-up and differential diagnosis]. | 1990 Jan | Generalized tendomyopathy (GTM), or fibromyalgia, is a disorder characterized by diffuse pain in the musculoskeletal apparatus which usually begins at a single site, e.g., as low-back pain or cervical syndrome, and develops into generalized pain over months or years. It is accompanied by increased tenderness at characteristic tender points, although the pain threshold on the whole is reduced. In addition to the main symptoms (pain in the musculoskeletal system, tenderness at the tender points), autonomic and functional symptoms are almost invariably present and are often accompanied by pathological psychological findings such as neuroses and depression. To date, no reliable laboratory parameters or pathognomonic histological findings have been identified. The disorder affects primarily women, beginning around the age of 35 and reaching its peak during or after the menopause. It also affects young people and those over age 60, although it is much less common in these cases. Secondary forms are observed particularly in rheumatoid arthritis. The differential diagnosis must first distinguish primary GTM from the secondary forms. There must also be further differentiation between internal and psychiatric disorders and primary GTM. This can be achieved in many cases by careful clinical diagnosis, although a more complete examination is sometimes required. | |
| 1964317 | [The regulation of B-lymphocyte activity by the Epstein-Barr virus in ankylosing spondylar | 1990 | Former studies of the authors have indicated a deficit of the suppressor function of the T-lymphocytes on the activity of the B-lymphocytes by the Epstein-Barr Virus (EBV) in systemic autoimmune diseases: in 60% of the patients with rheumatoid arthritis, 50% of the patients with systemic sclerosis and 80% of the patients with systemic lupus erythematodes. Deficit of the specific cytotoxic function of the EBV in ankylosing spondylarthritis has been described. A study was carried out on 13 patients with ankylosing spondylarthritis and 13 healthy controls. All were immunized with EBV. Cultures were made experimentally. The secretion of IgM and IgG in the supernatant of the cultures was tested by ELISA. The T-suppression function of the specific T-lymphocytes of the EBV is not decreased in ankylosing spondylarthritis. | |
| 2531567 | [Dilatation of the mitral and aortic valves. Current trends]. | 1989 Sep 30 | Following percutaneous endoluminal dilatation of the coronary arteries, new techniques developed in 1984 and 1986 respectively with the purpose of treating percutaneously adult mitral and aortic stenosis. Results of mitral valvuloplasty are excellent from an haemodynamic standpoint as well as an electrocardiographic and clinical standpoint. Anatomical lesions, especially commissural fissure, give a good explanation of these results. But this is a complex procedure, relatively rarely indicated today in France, because of the almost total disappearance of acute rheumatoid arthritis. Degenerative aortic stenosis is the most frequent valvulopathy in France. It occurs in elderly patients, after weak, in whom surgery is always a major risk. Dilatation seemed an interesting alternative to surgery. Unfortunately the results of aortic valvuloplasty are poor and most of the time temporary. However, improvement of the symptoms is observed in one out of two cases. These poor results are due to the nature of the anatomical lesion which respond poorly to valvuloplasty. | |
| 2597610 | Significance of a high erythrocyte sedimentation rate in general practice. | 1989 Jul | For eight months the erythrocyte sedimentation rate (ESR) was recorded prospectively in patients over 70 years of age to elucidate the prevalence and causes of high ESR in this age group. All patients having an ESR over 40 mm/h were thoroughly investigated. Ninety men and 349 women had their ESR taken. Sixteen men (18 per cent) and 42 women (12 per cent) had an ESR above this level. Eighty-four separate diagnoses were found to contribute to an elevation of the ESR. Twenty-eight patients (40 per cent of those with high ESR) had multiple diagnoses that might have contributed to the high ESR. The most frequent diagnoses were infection, especially chronic bronchitis, rheumatoid arthritis and renal failure. As a result of the study, nine new diagnoses were found and three patients could be offered effective treatment. We conclude that a multifactorial aetiology is common when the ESR is elevated and that a thorough examination is advisable in such cases. However, screening of ESR in elderly patients in general practice has little therapeutic consequence and selective use of the test is preferable. | |
| 2786296 | [The genetics of rheumatic diseases: genetic basis of the classification of multifactorial | 1989 | Examination of the pattern of hereditary predisposition allows a more precise determination of pathogenetic relationships between individual clinical forms and variants of multifactorial diseases (MFD), as well as assessment of the possibilities and approaches to a genetic classification to be made. The construction of genetic classifications is based on the identification of differences in the type of inheritance, the study of the progeny in families where both parents have the same or different forms of the disease, the results of the marker adhesion test, and the genetic correlation coefficients. The study has made use of some clinical forms of rheumatic diseases, whose relationships are a subject of controversy among the clinicians, as splitting phenotypes. Segregation analysis of the selected clinical forms of rheumatic diseases and genetic correlation coefficients obtained within the framework of a quasi-continuous model provide no indication that these forms can be isolated as independent nosologic entities. Possible phenotype splitting into individual subtypes and the potentialities of a marker approach to the construction of genetic MFD classifications are demonstrated, with rheumatoid arthritis associated with HLA antigen Dr 4 taken as an example. | |
| 2669108 | Interleukin-6: possible implications in human diseases. | 1989 Jan | It has been demonstrated that interleukin-6 (IL-6) is a cytokine regulating immune response, acute-phase reaction and hematopoiesis. The deregulated expression of IL-6 was suggested to be actually involved in the pathogenesis of polyclonal B cell activation and autoimmune diseases such as rheumatoid arthritis. It could be hypothesized that continuous polyclonal B cell activation may be eventually leading to the generation of plasmacytoma/myeloma, possibly with additional expression of oncogene(s) such as c-myc gene. Therefore, future studies on the gene regulation of IL-6 would provide critical informations on the molecular pathogenesis of these diseases. Furthermore, IL-6 could be used as anti-cancer drug in certain tumors. Moreover, inhibitors of IL-6 such as anti-IL-6 monoclonal antibodies or soluble forms of IL-6 receptors could be useful in the treatment of such polyclonal/monoclonal B cell abnormalities. |