Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8235666 | Bronchiolitis obliterans organizing pneumonia and rheumatoid arthritis. | 1993 Aug | The case of a 68-year-old woman who presented with dyspnea and upper lobe pulmonary infiltrates and shortly thereafter developed seropositive, erosive polyarticular rheumatoid arthritis (RA) is presented. An open-lung biopsy to evaluate progression of infiltrates showed bronchiolitis obliterans-organizing pneumonia (BOOP). Both lung and articular disease responded rapidly to corticosteroid therapy. Interrelationships between BOOP, bronchiolitis obliterans, and interstitial fibrosis with connective tissue disease are discussed. | |
| 7768057 | Anti-CD4 treatment of patients with rheumatoid arthritis. Is there still a place for this | 1994 Nov | As a result of a better understanding of the mechanisms that underlie autoimmune rheumatic diseases, biologic agents have been increasingly used in the therapy of rheumatoid arthritis (RA). The most extensive clinical experience has been obtained with monoclonal antibodies (mAb) against CD4. This brief communication will summarize the rationales for treating RA patients with CD4-Mab, the clinical effects observed so far, and the further treatment trials which are warranted before anti-CD4 monoclonal antibody therapy should be excluded from the therapeutic repertoire for RA and other autoimmune diseases. | |
| 1563037 | Rheumatoid arthritis in south-east Europe. | 1992 Feb | The clinical, serological and immunogenetic studies of RA in mediterranean countries and other small tribal groups have added some more information that is valuable in understanding the pathogenesis of RA. However, the immunogenetic studies seem to be more helpful in understanding the mechanisms of initiation of disease and its dissimilarities in different ethnic groups than in discovering its cause. It should also be stressed that, in addition to genetic factors, other factors may influence disease expression. This proposal was supported by a study from Africa which revealed an increasing incidence and severity of RA in rural compared with urbanized African populations (Brighton, 1987). Thus, the variability factor influencing disease expression may lie in the environment (Woodrow, 1988). | |
| 7631040 | A database for rheumatoid arthritis. | 1995 May | This article describes a methodology for the establishment and maintenance of a longitudinal rheumatoid arthritis database, addresses concerns regarding validity and reliability of longitudinal data collection in the setting of clinical care and research, and describes and recommends specific variables for minimal, moderate, and extensive levels of database detail. | |
| 8883429 | Margaret Holroyd Prize Essay. A patient-centred approach to evaluation and treatment in rh | 1996 Oct | Assessment of patient-centered outcomes is of particular importance in a chronic disease such as rheumatoid arthritis (RA), where a major aim of treatment is a reduction of its disabling and handicapping effects. Rheumatology is reasonably well advanced in its deployment of such outcomes. Measurement of the patient's experience of disease has focused on the ability to perform daily living tasks and, latterly, on the more global effect on quality of life. Neither of these approaches is without conceptual and measurement problems. A new measure of patient-centred outcome in RA has been developed (Carr AJ, Br J Rheumatol 1994;33:378-82). This tool, the Disease Repercussion Profile (DRP), attempts to extend the measurement of outcome to incorporate the individual functional, social, psychological, emotional and economic disadvantage resulting from RA, i.e. patient-perceived handicap. It has been designed for use as a clinical tool, to allow patients to specify the problems and needs of most importance to them, and as such represents a new approach. This paper reviews the development of the DRP in the context of existing health status measures and examines its potential role as a routine measure in an out-patient setting. | |
| 8882129 | Incidence of rheumatoid arthritis in Finland during 1980-1990. | 1996 Sep | OBJECTIVE: To obtain information on the incidence of rheumatoid arthritis and on its recent trends in Finland. METHODS: The study covered those subjects entitled to receive specially reimbursed medication for rheumatoid arthritis under the nationwide sickness insurance scheme in five out of 21 central hospital districts in Finland (population basis about one million adults) during three years: 1980, 1985, and 1990. RESULTS: The annual incidence of rheumatoid arthritis in 1980 and 1985, satisfying the American Rheumatism Association 1987 classification criteria, was 39/100,000 of the population > or = 16 years of age. The combined incidence of rheumatoid factor (RF) positive arthritis and RF negative polyarthritis was 46/100,000. A decline of approximately 40% occurred in the number of RF negative rheumatoid arthritis cases in 1990 compared with the earlier years. The declining trend was statistically significant (P = 0.008). CONCLUSION: The decline in incidence of RF negative rheumatoid arthritis in Finland may reflect changes in the environment specifically affecting the risk of RF negative disease. | |
| 7835018 | Klinefelter's syndrome and rheumatoid arthritis. Report of a case and review of the litera | 1994 Sep | Our case report describes a patient with Klinefelter's syndrome (KFS) associated with rheumatoid arthritis (RA). He had active RA in 1985 but his arthritis almost subsided in 1993 without intensive treatments for RA as well as KFS. Recently, the lower levels of testosterone in male RA patients, especially at the active phase has been reported. However, it is still questionable whether hypogonadism is a predisposing factor or just a consequence of disease. Since our case had a mild clinical course, and since the incidence of RA associated with KFS is very rare in comparison with other rheumatic diseases, may suggest that the low levels of testosterone are not a predisposing factor to the activity of RA. | |
| 7858812 | Anaesthetic risks in rheumatoid arthritis. | 1994 Oct 5 | Rheumatoid arthritis can be a major challenge to the anaesthetist, the principal problem being a difficult upper airway. Additional risks may arise because of cardiovascular and pulmonary involvement. The drugs used in the treatment of rheumatoid arthritis also affect the anaesthetic management of these patients. | |
| 8761796 | [Association of polymyositis and rheumatoid arthritis. Apropos of a new case not related t | 1996 | Muscular manifestations are frequent during rheumatoid arthritis, mostly induced by drugs. In contrast with rheumatoid myositis whose existence has been debated, penicillamine induced polymyositis and dermatomyositis are well described. We report a case of rheumatoid arthritis associated with non-drug induced polymyositis. | |
| 1475630 | Disease modification in rheumatoid arthritis with special reference to cyclosporin A. | 1992 | Disease modifying antirheumatic drugs improve clinical markers of synovial inflammation as well as acute phase reactants and functional status in patients with rheumatoid arthritis. Some of the disease modifying antirheumatic drugs probably also retard radiographic progression. Data from prospective observational studies and epidemiological studies indicate a modest and temporary effect. New treatment modalities are needed, including both new strategies and new drugs. Cyclosporin A improves clinical markers of synovial inflammation and is useful for individual patients with rheumatoid arthritis. However, further studies are required to investigate the long term efficacy and tolerance of cyclosporin in rheumatoid arthritis. | |
| 7645475 | Rheumatoid arthritis of the craniocervical region by MR imaging: detection and characteriz | 1995 Sep | OBJECTIVE: The purpose of our study was to evaluate the potential of contrast-enhanced MR imaging to detect and to characterize craniocervical rheumatoid arthritis in a large population group, to compare MR imaging with clinical and conventional radiographic findings, and to examine the relationship between the histopathologic and MR imaging findings in seven patients. SUBJECTS AND METHODS: We performed contrast-enhanced MR imaging using T2-weighted gradient-echo sequences and T1-weighted spin-echo sequences in 136 patients with rheumatoid arthritis. Sequential T1-weighted images were obtained before, 3 min after, and 15 min after injection of contrast material. Plain films were acquired in all patients. Serologic status and neurologic status were determined in each patient within 2 days of MR imaging. Patients were categorized into one of four groups, depending upon whether they had joint effusion, hypervascular pannus, hypovascular pannus, or fibrous pannus according to signal patterns on contrast-enhanced MR images. Signal intensity was measured to assess the enhancement of synovial hypertrophy, joint capsule, joint effusion, and the various stages of pannus tissue. Histologic specimens were obtained from seven patients and were correlated with MR imaging findings. RESULTS: Acute and chronic synovitis were differentiated with contrast-enhanced MR imaging as follows: joint effusion (n = 29), hypervascular pannus (n = 54), hypovascular pannus tissue (n = 8), and fibrous pannus (n = 22). Signal intensity differed significantly among the four groups on contrast-enhanced T1-weighted images. In 59 patients with effusion or hypervascular pannus tissue, atlantoaxial subluxation was diagnosed with plain films. Patients with negative findings on radiographic studies (n = 20) had joint effusion, hypervascular pannus tissue, hypovascular pannus formation, or fibrous pannus tissue on MR imaging studies. Cord compression was found in 10% of all cases and isolated sac compression in 16%. Neurologic findings showed no correlation with MR imaging features. CONCLUSION: Contrast-enhanced T1-weighted spin-echo MR imaging can discriminate between joint effusion and various forms of pannus in patients with rheumatoid arthritis of the craniocervical region. MR imaging also can detect joint effusion and pannus tissue in patients with negative radiographic findings. No relationship between MR imaging findings and clinical symptoms were found. Tissue enhancement and histopathologic findings correlated in a limited number of autopsies. | |
| 8686046 | [Kidney function problems in rheumatoid arthritis]. | 1996 May 27 | Rheumatoid arthritis is a systemic, disabling disease with significant excess mortality which is partly caused by renal disease, infection and renal insufficiency being the main contributors. The bulk of renal problems in reumatoid arthritis are related to complications such as vasculitis and amyloidosis, and complications to the medical treatment of the disease, the main offenders being gold salts, penicillamine and cyclosporine. Also, there is increasing evidence that reumatoid arthritis per se can cause subclinical renal dysfunction with microalbuminuria as well as clinical disease, caused by immune-complex mediated glomerulonephritis and interstitial tubular fibrosis. In reumatoid arthritis serum creatinine can overestimate renal function by as much as 30% and it is suggested that more sensitive methods such as measuring urinary albumin excretion and glomerular filtration rate should be used for monitoring renal function. | |
| 8722875 | Perioperative management of the rheumatoid patient. | 1996 Mar | Rheumatoid arthritis is a systemic disease that can affect multiple organ systems of the body. It is a symmetrical polyarthropathy which leads to destruction of cartilage and bone. Before undertaking surgery on the rheumatoid patient, several issues need to be addressed. A thorough evaluation by a multidisciplinary team is essential to decrease any operative risks involved. This is a review of some of the systemic manifestations of rheumatoid arthritis with an emphasis on anesthesiology, and radiological consultation, and perioperative surgical management of rheumatoid drug therapy. | |
| 1582080 | The genetic epidemiology of rheumatoid arthritis. | 1992 May | This review considers the epidemiological aspects of the genetic investigation of rheumatoid arthritis (RA). Problems both of disease definition and disease heterogeneity render studies difficult to undertake and interpret. The selection of individuals both in population and family studies can explain divergent results. Despite the insights into the immunopathogenesis of RA afforded by the demonstration of an association between the disease and HLA class II genes, the latter have only a limited role in explaining differences, both between individuals and between populations, in susceptibility to RA. | |
| 1475635 | Salmonella-triggered reactive arthritis. | 1992 | Clinical significance of Salmonella-triggered reactive arthritis is rising, because the frequency of Salmonella infections is increasing all over the world. In this study reports on Salmonella-triggered reactive arthritis have been reviewed. A summary of clinical, epidemiological and laboratory data, as well as triggering serotypes, is presented. Diagnostic and therapeutic aspects are also discussed. | |
| 9088168 | Rheumatoid diseases and the temporomandibular joint: a review. | 1995 Oct | Rheumatic diseases cause patients to seek care for musculoskeletal pain or dysfunction, as well as other problems. Rheumatic diseases are musculoskeletal and connective tissue disorders demonstrating chronicity, variability, and periods of exacerbation and remission. Practitioners must be aware of the features of many of these diseases and be able to address patients' concerns, especially as they relate to the temporomandibular joint, temporomandibular dysfunction, and/or myofascial pain. Rheumatoid arthritis and systemic lupus erythematosus are sufficiently common to necessitate the dental practitioner having a working knowledge of both of these diseases. This paper presents the salient points of the general pathology of rheumatoid arthritis and systemic lupus erythematosus and specifics of temporomandibular involvement in rheumatoid arthritis. | |
| 1375299 | [Histopathological characteristics of rheumatoid arthritis--as a clue to elucidate its pat | 1992 Mar | A correct histopathological diagnosis of Rheumatoid Arthritis (RA) is quite important for the decision of early phase treatment to cure it fundamentally. But, generally speaking, usual hospital pathologist is not so much experienced about RA. The purpose of this article is originally to let such pathologist familiar in RA pathology, but for the RA specialist to offer any clue to elucidate the still-unknown etio-pathogenesis of RA or to cure RA fundamentally. The "Tetralogy of RA Arthritis for pathologist" must be as follows: (1) Enormous proliferation of well-permeable granulation-tissue-type neo-vascularization, some of which became high column-endothelial and the center of primary as well as secondary follicle-like lymphoid cell cluster. (2) Lymphoid cluster in RA synovium is also pathological in function. It consisted of preferentially CD4T and B cells to produce IgG rheumatoid factor endlessly. (3) Synovial lining A and B cells proliferate as far as five layers of each, but later, the sublining D (M) and D (F) cells proliferate more and more and finally replace the lining cells. D (M) cells express macrophage marker and full of lysosome, on the contrary, D (F) cells express mesenchymal marker and contains much metalloproteinase. Both express strong Class II antigens but neither has complement activation inhibitor DAF. (4) Proliferation of these D cells with full of mesenchymal tissue destroying and inflammation accelerating activity must be playing a major role in the joint destruction of RA, some in shape of pannus and more in shape of granulation tissue in and around the bone. | |
| 8796981 | Established and new biochemical tools for diagnosis and monitoring of rheumatoid arthritis | 1996 May | Rheumatoid arthritis is clinically heterogeneous, and early aggressive therapy is probably not always warranted. A large number of biochemical and biologic markers are under investigation for possible usefulness in diagnostic and prognostic work. These markers can be divided into three main categories: disease specific, inflammatory, and tissue specific. Markers may be useful in the study of prognosis and response to therapy, whereas the diagnostic information they provide is limited. Marker metabolism is largely unexplored, and validation of most marker analyses is lacking. However, they are interesting research tools and may in the end not only teach lessons on the pathogenesis of the disease but also help in selecting patients early for aggressive disease or detecting response or lack of response to therapy. | |
| 1341421 | Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. | 1992 Oct | Palindromic rheumatism (PR), originally described in 1944, is characterized by recurrent episodes of mostly oligoarticular arthritis with peri- and para-articular tissue inflammation, leaving no residual clinical and radiographic changes. It appears that palindromic syndrome is a heterogeneous entity, encompassing other inflammatory conditions at early stages of their evolution, and whose relationship with rheumatoid arthritis (RA) is evident but still unclear. Evolution of up to 50% of these cases into otherwise typical RA, commonly accompanied by the conversion to rheumatoid factor seropositivity, the frequent occurrence of nodules, the reported response to RA treatment, and the observation of familial aggregation of the two conditions suggest that PR is part of the spectrum, or a stage in the evolution of RA. However, justification for the distinct existence of PR comes from reports that identify well-defined and recognizable clinical manifestations such as descriptions of the acute attacks, the frequent peri-articular manifestations, the absence of bone and cartilage destruction even after extended periods of time, and the generally good long-term prognosis. Immunogenetic studies with HLA-DR phenotyping and the absence of female preponderance tend to add additional support for the separate identity of PR. | |
| 1556266 | Rheumatoid neutrophilic dermatitis. | 1992 Feb | Rheumatoid neutrophilic dermatitis is a rare entity reported to occur in association with severe rheumatoid arthritis. Three patients with seropositive rheumatoid arthritis and rheumatoid neutrophilic dermatitis are described. Clinically, the eruption is characterized by symmetric erythematous papules, plaques, and rarely vesicles on extensor skin surfaces. Light microscopy reveals a dermal neutrophilic infiltrate without vasculitis. Spongiotic intraepidermal blisters, subepidermal bullae, or papillary neutrophilic microabscesses may be seen. The histologic differential diagnosis includes the other dermatoses in which neutrophils predominate. Rheumatoid neutrophilic dermatitis is one of several neutrophilic dermatoses seen in association with rheumatoid arthritis, suggesting that it may be part of a spectrum of neutrophilic cutaneous reaction patterns in a predisposed host. |