Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8295176 | Fractures in rheumatoid arthritis: an evaluation of associated risk factors. | 1993 Oct | OBJECTIVE: Our purpose was to identify factors indicative of a high fracture risk during the disease course of rheumatoid arthritis (RA). METHODS: In 1110 patients (879 women and 231 men) with RA from five Arthritis, Rheumatism and Aging Medical Information System centers, information from history, clinical and laboratory examination, outcome assessment, and therapy was evaluated for association with the 226 first fractures having occurred during the years from 1975 to 1988. RESULTS: The mean age of the patients was 54 years, the mean time of observation was 8 years. Multivariate analyses identified the following factors to be associated with fracturing: years taking prednisone, previous diagnosis of osteoporosis, disability, age, lack of physical activity, female sex, disease duration, impaired grip strength, and low body mass. CONCLUSION: We conclude that patients with RA at greatest risk for fracturing are easily identified by using a few clinical variables. These findings support encouragement of active lifestyle habits and avoidance of longterm administration of corticosteroids in patients with RA. | |
| 8005266 | Bronchiolitis obliterans: the lone manifestation of rheumatoid arthritis? | 1994 Apr | The patient was a 62 year old man, who suddenly developed obstructive lung disease without a readily definable cause. He had a remarkable family history of deforming rheumatoid arthritis, and a serum rheumatoid factor of 1:1,256, but with no evidence of active rheumatological disease. Clinical, physiological and radiologic features suggested bronchiolitis obliterans, and this was confirmed by open lung biopsy. Immune staining of tissue revealed immunoglobulin M (IgM) as well as rare immunoglobulin (IgG) containing plasma cells in a peribronchiolar location. Because of these findings, we suggest that this case represents bronchiolitis obliterans secondary to a rheumatoid process. This case is unusual since it appeared in a man and is the first and, so far, the only manifestation of rheumatoid arthritis. Prior studies indicate that the bronchiolitis obliterans of rheumatoid arthritis occurs primarily in women and only in ongoing cases. | |
| 8610256 | Surgical management of cervical rheumatoid problems. | 1995 Dec 1 | This update reviews current thinking on the development of cervical spine problems and describes the histological and macroscopic changes in rheumatoid arthritis. A plea is made for a standard classification and grading system so that comparisons of various treatment policies can be scientifically assessed. The various types of surgical procedure are described and outcome evaluated on the basis of the natural history of the condition. | |
| 7797705 | Women's experiences of rheumatoid arthritis. | 1995 Apr | This paper is based on findings drawn from research undertaken within a qualitative framework of analysis. The purpose of the research was to explore women's experiences of rheumatoid arthritis. Three areas of concern to the women are identified and discussed in the light of relevant literature. They are as follows: seeking help, searching for meaning and uncertainty about symptoms. A major theoretical concern of both authors is to demonstrate the importance of placing patients' personal accounts of their experiences and understandings at the centre of nursing interest and practice. It is argued that there is a need to develop research studies of how patients experience disease, in order to develop a basis for good practice. | |
| 8998314 | [Pulmonary manifestations in rheumatoid arthritis: high-resolution computed tomography in | 1996 Nov | PURPOSE: It has been the aim of the following study to evaluate pulmonary changes in rheumatoid arthritis with high-resolution CT and to assess their correlation with joint manifestation and laboratory parameters. MATERIAL AND METHODS: The authors prospectively performed computed tomography (CT) in 83 patients with rheumatoid arthritis and graded pulmonary changes for frequency and severity. Included were patients with 6-7/7 ARA, BSR > 25/1 min and mean disease duration of 12 years (range, 1-44). Data of medical and drug histories, smoking habits, blood levels of rheumatoid factor (RF), antinuclear antibodies (ANA) and C-reactive protein as well as the degree of joint involvement were taken into account. RESULTS: 58 patients (70%) had pathological CT scans showing the following abnormalities: interlobular thickening (44.5%), intralobular thickening (34%), nonseptal linear attenuation (35%), nodular or linear pleural thickening (32.5%), ground-glass pattern (19%), centrilobular nodules (13%), honeycombing (13%) and bronchiolectasis (9%). Intralobular thickening, honeycombing and pleural thickening were associated with a higher degree of joint manifestation; pleural thickening, honeycombing and ground-glass pattern were associated with a higher level of rheumatoid factor. There was no relationship between pulmonary changes and either the duration of the disease, antinuclear antibodies (ANA) or C-reactive protein. CONCLUSION: CT may be a useful noninvasive tool for recognition of RA-associated lung disease. Interstitial lung changes are frequent and they are independent of the duration of the disease. Pulmonary interstitial changes are more frequent and more severe in RF-positive patients and in case of more severe joint involvement. | |
| 7747143 | Relationship of rheumatoid factor to lung diffusion capacity in smoking and non-smoking pa | 1995 | We studied the relationship of serum rheumatoid factor (RF) and certain other variables to lung diffusion capacity for carbon monoxide (DLCO) in patients with rheumatoid arthritis (RA). In non-smoking patients none of the examined variables correlated significantly to DLCO whereas in smokers RF showed a significant (p < 0.01) negative correlation in this respect. These results indicate that smoking in connection with RF may contribute to reduced DLCO in RA patients. | |
| 8646202 | Resection arthroplasty of the forefoot in rheumatoid arthritis cases. | 1995 Nov | Resection arthroplasty of the forefoot was performed in 30 patients (48 feet) with rheumatoid arthritis. A Keller/Clayton procedure yielded good results, whereas a less radical operation (Hybbinette) created poor results. Reoperation following failed Hybbinette operations was possible. | |
| 8339122 | The expression of rheumatoid arthritis in Malaysian and British patients: a comparative st | 1993 Jul | Seventy consecutive patients with definite or classical RA attending a University Hospital Rheumatology Clinic in Malaysia, were compared with an age, sex, disease duration matched group of RA patients seen in a British University Hospital. There were no differences in measures of disease activity, overall functional status or serological status in the two groups. However significant differences were seen in both the articular and extra-articular manifestations of the disease in the two countries. British patients had more severe disease in the feet, and a higher prevalence of nodules, vasculitis and pulmonary fibrosis. The Malaysian population had fewer erosions, more frequent involvement of the wrists and cervical spine, and a much higher incidence of secondary sicca syndrome. Radiographic changes were generally milder in Malaysian patients. Possible reasons for these differences in the expression of RA in the two countries are discussed. | |
| 8424839 | Fecundity before disease onset in women with rheumatoid arthritis. | 1993 Jan | OBJECTIVE: To examine fecundity prior to disease onset in women with rheumatoid arthritis (RA). METHODS: Two hundred fifty-nine RA patients with an opportunity for pregnancy were compared with 1,258 control women as part of a prospective case-control study of recent-onset RA in women. RESULTS: A 12-month or longer interval to pregnancy was found in 42% of RA cases compared with 34% of controls (odds ratio = 1.44, 95% confidence interval 1.10, 1.91). This difference was not accounted for by an older age when attempting to become pregnant among the RA cases compared with the controls. The result was unrelated to rheumatoid factor or HLA-DR4 status. CONCLUSION: Women with RA were found to have decreased fecundity prior to disease onset, compared with control women. | |
| 9045753 | The autonomic nervous system and the immune system in juvenile rheumatoid arthritis. | 1996 Dec | This study demonstrates that juvenile rheumatoid arthritis is associated with a dysregulation of the autonomic nervous system as well as with disturbances in the capacity of the immune system to respond to mediators of the autonomic nervous system. In patients with active disease heart rate at rest is higher than in healthy controls. In addition, 3-hydroxy-4-phenoxyphenylglycol levels in urine are higher in all patients than in the control group. Cardiovascular responses to an orthostatic stress test (tilt up) are reduced in patients with active and nonactive disease. Plasma norepinephrine responses to tilt up are reduced in subjects with active juvenile rheumatoid arthritis. In summary, our data show that patients with juvenile rheumatoid arthritis have an altered function of the autonomic nervous system associated with increased central noradrenergic outflow, presumably leading to increased vasoconstriction, resulting in a decreased response to an orthostatic stressor. The altered function of the autonomic nervous system is associated with changes in the response of leukocytes to mediators of the autonomic nervous system via beta2-adrenergic receptors. Leukocytes of patients with active juvenile rheumatoid arthritis have a lower cAMP response to a beta2-adrenergic agonist, presumably due to increased cAMP-phosphodiesterase activity in these cells. | |
| 7903034 | Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: a | 1993 Oct | OBJECTIVES: To compare the effects of hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis. METHODS: A six month randomised, multicentre, double blind trial with three parallel groups was performed. Ninety one outpatients with active rheumatoid arthritis were included. Monthly assessments of erythrocyte sedimentation rate, morning stiffness, number of swollen joints, a pain score, and global assessments were carried out. Radiographs of hands and wrists were taken before and after the trial. RESULTS: Sixty two patients completed the study. The 29 withdrawals caused no evident bias, and there was no difference in side effects among the three groups. All variables improved significantly with time. Patients treated with a combination of hydroxychloroquine and sulphasalazine responded better and faster than those treated with hydroxychloroquine alone, but there was no statistically significant difference between the combination treatment and single drug treatment with sulphasalazine or between treatment with hydroxychloroquine and sulphasalazine given alone. CONCLUSION: The present results do not support a recommendation to use a combination of hydroxychloroquine and sulphasalazine in the treatment of rheumatoid arthritis. | |
| 7862595 | Evaluation of a rheumatoid arthritis patient education program: impact on knowledge and se | 1994 Aug | We have evaluated the effects of an education program on the knowledge and self-efficacy of 51 rheumatoid arthritis patients, using two previously validated questionnaires. At completion of the program, both knowledge and self-efficacy were significantly improved and this was maintained at follow-up. However, there was no correlation between knowledge and self-efficacy at baseline and follow-up, suggesting that these variables improved independently of each other. We conclude that education programs are a worthwhile means of improving the non-medical causes of morbidity in rheumatoid arthritis patients and that the two instruments utilized are a valuable means of both demonstrating effectiveness and quality assurance. | |
| 7810240 | Rheumatoid nodules located in the penis of a methotrexate-treated patient with rheumatoid | 1994 Sep | A case is reported in which a patient with a rheumatoid factor-negative rheumatoid arthritis developed rheumatoid nodules in the penis during treatment with methotrexate. The development of rheumatoid nodules in seronegative rheumatoid arthritis patients is extremely rare. An acceleration of rheumatoid nodules in methotrexate-treated rheumatoid arthritis patients is reported in literature. Regarding the case reported here, we propose a causal relationship between methotrexate-treatment and the development of rheumatoid nodules in our patient. Methotrexate should not be the preferential treatment for patients with rheumatoid arthritis developing rheumatoid nodules and suffering from vasculitis. | |
| 8455994 | Correlates of fatigue in older adults with rheumatoid arthritis. | 1993 Mar | The purposes of this study were to describe the prevalence of fatigue, examine the association between fatigue and doctor visits, and identify correlates of fatigue in rheumatoid arthritis (RA). On average, a high degree of fatigue was reported to occur every day, to remain constant during the course of a week, and to most often affect walking and household chores. When controlling for disease severity and insurance coverage, respondents who reported more fatigue made more visits to the rheumatologist than those reporting less fatigue. A regression model with fatigue as the dependent variable revealed that the following variables explained a significant amount of variance: pain rating, functional status, sleep quality, female gender, comorbid conditions, and duration of disease. | |
| 8293004 | [Antigliadin antibodies in rheumatoid arthritis]. | 1993 Mar | To investigate the potential role of gliadin in the pathophysiology of some cases of rheumatoid arthritis (RA), the authors assayed antigliadin antibodies (AGAb) in RA patients. They used an ELISA to determine AGAb levels in 100 RA patients, a group of RA-free controls with a variety of inflammatory diseases (ID), and a group of controls with noninflammatory diseases (NID). The authors found no significant increase in AGAb titers in the RA patient group as compared with either control group. Only nine patients with RA had detectable levels of AGAbs, which were of the IgG type in seven cases and of the IgA type in two cases. RA patients with and without AGAbs were compared. Patients with AGAbs more often had signs of autoimmune disease including sicca syndrome, positive tests for rheumatoid factor, and positive tests for antinuclear antibodies. | |
| 7659451 | Pathophysiology of the rheumatoid joint. | 1995 Jul | The precise cause of rheumatoid arthritis (RA) is, as yet, unknown. But with more sophisticated techniques in the fields of immunogenetics and molecular biology, there is increasing knowledge of the pathophysiology of the rheumatoid joint. Pathophysiologic knowledge should be part of the orthopaedic nurse's repertoire when dealing with the "whole" patient; therefore orthopaedic nurses who care for patients with rheumatoid disease should understand certain pathophysiologic concepts. This article reviews the pathophysiology of the rheumatoid joint and describes the changes that take place in the joint with specific reference to the cells of the immune system, the synovium, and articular cartilage. | |
| 1486755 | Rheumatoid arthritis associated with ankylosing spondylitis defined by scintigraphic and C | 1992 Dec | Rheumatoid arthritis and ankylosing spondylitis were detected in the same patient after a long period of observation of the disease. X-ray studies demonstrated the characteristic rheumatoid arthritis changes in peripheral joints. By contrast, few X-ray changes of ankylosing spondylitis were detected, during follow-up. Diagnostic approach through scintigraphic studies disclosed a symmetric uptake of the radionuclide in sacroiliac joints, and computed tomography revealed bilateral ankylosis. The combination of these tests was useful to define the presence of axial disease. This patient was both HLA B27 and DR4 positive. Rheumatoid arthritis occurred before ankylosing spondylitis, that interestingly was defined as a late onset disease. | |
| 7791155 | Comparison of self-reported fatigue in rheumatoid arthritis and controls. | 1995 Apr | OBJECTIVE: To compare self-reported fatigue in adults with rheumatoid arthritis (RA) with age and sex matched healthy controls without RA and to determine the relationships of fatigue to pain, sleep, functional status, depressive symptoms, and disease activity. METHODS: A sample of 51 patients with RA and 46 age and sex matched controls without RA completed self-administered questionnaires 3 times at 6-8 week intervals. Questionnaires included the Multidimensional Assessment of Fatigue scale, Sleep Survey, Health Assessment Questionnaire, and the Profile of Mood States. Patients had blood drawn for hematocrit (Hct) and C-reactive protein on the same day the questionnaires were completed. RESULTS: Fatigue scores were significantly higher in persons with RA compared to healthy controls. Fatigue did not change significantly in either group over time. Fatigue was strongly associated with poor sleep, functional disability, greater pain, more depressive symptoms, and lower Hct. CONCLUSION: The importance of assessing fatigue in RA is confirmed. Effective management is needed to control clinical manifestations of RA that were found to be strongly associated with fatigue such as poor sleep, functional disability, pain, depressive symptoms, and lower Hct. | |
| 7744979 | Cytokines, inflammation, and autoimmune diseases. | 1995 May 15 | The understanding of cytokines is in its infancy, but it appears that overproduction or deficiency of these intracellular mediators may contribute to inflammatory and autoimmune diseases such as insulin-dependent diabetes mellitus and rheumatoid arthritis. As the complexities of cytokine actions and interactions are unraveled, therapeutic blockade or upregulation may be possible. | |
| 8610222 | Raised IgA rheumatoid factor (RF) but not IgM RF or IgG RF is associated with extra-articu | 1995 | In rheumatoid arthritis (RA) seropositivity has been associated with poor prognosis including bone erosions and extra-articular manifestations. However, findings have been conflicting on the association between individual rheumatoid factor (RF) isotypes and extra-articular manifestations. In this study the occurrence of extra-articular manifestations was examined in the context of the RF isotype patterns rather than individual RF isotypes. IgM, IgG and IgA RF was measured by ELISA in 74 patients with RA and the findings correlated with the presence or absence of extra-articular manifestations. Of the IgA RF positive patients 80% had one or more extra-articular manifestations. In contrast, only 21% of patients with raised IgM and/or IgG RF but normal IgA RF had some extra-articular manifestations and 27% of the seronegative patients. It is concluded that the previously reported association between raised RF and extra-articular manifestations in RA can largely be attributed to the IgA RF isotype. |