Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8744652 | Oral heparin in the treatment of rheumatoid arthritis. | 1995 | Heparin was administered orally in 10 patients with rheumatoid arthritis. The treatment resulted in clinical improvement in all cases (significant reduction in the number of tender and swollen joints and morning stiffness). This was associated with a decrease in erythrocyte sedimentation rate (8/10 patients) and cholesterol in all patients, although the differences were not significant. Recent data indicate that heparin can bind cytokines with potent immune modulatory action (e.g. TNF-alpha, interferon gamma etc.). Thus, neutralization of their action on target cells could be partially responsible for the beneficial effects reported. Moreover, heparin inhibits T cell traffic to a site of antigen by blocking enzymes digesting the extracellular matrix and interfering with selection activity. The results of our preliminary study suggest that heparin, given per os, may have immunomodulatory properties with potential application in human disease. | |
| 8108671 | Disease characteristics, level of self-esteem and psychological well-being in rheumatoid a | 1994 | The present study addresses the relationship between early rheumatoid arthritis and an element of personality i.e. the self-esteem, as an intervening variable on psychological well-being. From a sample of 292, more or less recently diagnosed RA-patients, the relationships between disease parameters, self-esteem and psychological well-being were studied. Five subgroups of patients have been formed according to the duration of the disease: from four years disease duration up to incident cases. Disease parameters such as the duration of RA or the sedimentation rate is not associated with patients' self-esteem. The self-esteem of RA-patients is negatively related to the level of joint tenderness. Also, the lower the self-esteem of patients, the lower the level of psychological well-being. Joint tenderness with the patients' level of self-esteem explain 34% of the scoring on psychological well-being. | |
| 8448629 | An international consensus report: the use of cyclosporin A in rheumatoid arthritis. | 1993 Mar | Rheumatoid arthritis (RA) is a painful and disabling condition that is becoming increasingly widely recognized as associated with early mortality. Since the late 1970s, clinical trials have been conducted in both Europe and North America in order to determine whether oral cyclosporin A (CyA) has a role in the management of RA and, if so, how it might best be used. That experience, plus recent advances in our understanding of the mechanisms of action of CyA and of the pathology of RA, provides the foundation for the following consensus recommendations. It is assumed that physicians experienced both in the management of refractory RA and in the use of CyA will be treating patients outside experimental research protocols. All patients will be informed of the potential risks and benefits of treatment with CyA. Any patient to be started on CyA will have a documented complete past medical history, present history and physical examination. | |
| 7511830 | [Synovial angiogenesis]. | 1993 Nov 1 | Synovial angiogenesis i.e. the formation of new capillaries from pre-existent capillaries, is a prominent feature of articular inflammation. Since its regulation is tightly controlled, angiogenesis should disappear after recovery from acute episode. However, it may persist in chronic synovial inflammation such as rheumatoid arthritis (RA). Thus RA should be considered as an "angiogenic disease". This is the result of biochemical events which have contributed to the breakdown of the extracellular matrix and to the release of angiogenic factors in the local micro-environment. The growth of the pannus is dependent on the local angiogenesis which contributes to the destruction of joint cartilage. The development of inhibitors of synovial angiogenesis could offer a new therapeutic hope in RA. | |
| 8452766 | Health care research in rheumatology. | 1993 Mar | In the first three sections of this review, studies of disability among patients with musculoskeletal conditions are discussed. Evidence continues to demonstrate that arthritis has a substantial impact on disability. Correlates of disability for patients with general musculoskeletal conditions, rheumatoid arthritis, and osteoarthritis are reviewed, as are strategies to ameliorate arthritis-related disability. The fourth section of this review highlights the importance of pain-coping strategies for arthritis patients. The concluding section reviews educational strategies in the rheumatic diseases. | |
| 8243122 | CT detection of wrist bone erosion in rheumatoid arthritis. | 1993 Jul | A correlative radiographic and CT study of the wrists of 30 patients with rheumatoid arthritis (RA) was reported. The results showed that sensitivity of CT in detecting wrist erosion is superior to that of conventional radiograph. Accordingly, wrist CT scanning is useful for early diagnosis of RA. | |
| 1290480 | Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoi | 1992 Feb | Two patients are described with severe and progressive rheumatoid arthritis in whom methotrexate was reintroduced despite previous methotrexate related pneumonitis. In both patients a marked improvement in disease control occurred without a recurrence of the pneumonitis. | |
| 1589956 | Lymphocyte populations in the synovial membranes of dogs with rheumatoid arthritis. | 1992 Mar | Lymphocyte populations in the synovial membranes of dogs with canine rheumatoid arthritis (CRA) were investigated by immunohistochemical staining techniques. T-lymphocytes were the predominant cell type distributed throughout the supporting layer of the synovial membranes. B-lymphocytes expressing IgG were seen far more commonly than those expressing either IgA or IgM. Synovial membrane biopsies from normal and osteoarthritic joints did not have the marked cellular infiltrates seen in joints with CRA. The synovial immunohistopathological features in dogs with CRA are similar to those seen in human rheumatoid arthritis. | |
| 8371204 | Influence of methotrexate on the frequency of postoperative infectious complications in pa | 1993 Jul | OBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. RESULTS: Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). CONCLUSION: We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion. | |
| 7481120 | [Spontaneous use of active and passive coping strategies for pain in patients with rheumat | 1993 | The aim of the study was to determine association between active and passive pain coping strategies with some psychological and functional variables in 67 chronic RA patients. Active strategies reveal negative association with helplessness with as results of illness, and passive strategies reveal positive association with depression, helplessness and functional impairment. The patients who are using mostly active pain coping strategies reveal significantly less helplessness in coping with RA. | |
| 8882130 | Parasympathetic dysfunction in rheumatoid arthritis patients with ocular dryness. | 1996 Sep | OBJECTIVE: To determine whether abnormalities in the function of the autonomic nervous system are associated with oral and ocular dryness in rheumatoid arthritis. METHODS: Pupillography was done using an infrared light reflection method (IRIS) to measure both parasympathetic function (constriction latency and the latency of maximum constriction velocity (MCV)) and sympathetic function (dilatation latency) in rheumatoid arthritis patients with and without ocular dryness. The Schirmer and Saxon tests were used to measure the tear and saliva production respectively. RESULTS: The Schirmer and Saxon test results in rheumatoid arthritis patients with ocular dryness were reduced (P < 0.05) compared with rheumatoid arthritis patients without ocular dryness and healthy controls. Constriction latency and MCV latency were prolonged in rheumatoid arthritis patients with ocular dryness compared to the other two groups (P < 0.05). A negative correlation was found between the degree of ocular dryness and both constriction latency and MCV latency. No correlation was found between the results of pupillography and saliva production. CONCLUSIONS: Parasympathetic dysfunction may play a role in ocular dryness in patients with rheumatoid arthritis. | |
| 8507213 | The American College of Rheumatology preliminary core set of disease activity measures for | 1993 Jun | OBJECTIVE: To develop a set of disease activity measures for use in rheumatoid arthritis (RA) clinical trials, as well as to recommend specific methods for assessing each outcome measure. This is not intended to be a restrictive list, but rather, a core set of measures that should be included in all trials. METHODS: We evaluated disease activity measures commonly used in RA trials, to determine which measures best met each of 5 types of validity: construct, face, content, criterion, and discriminant. The evaluation consisted of an initial structured review of the literature on the validity of measures, with an analysis of data obtained from clinical trials to fill in gaps in this literature. A committee of experts in clinical trials, health services research, and biostatistics reviewed the validity data. A nominal group process method was used to reach consensus on a core set of disease activity measures. This set was then reviewed and finalized at an international conference on outcome measures for RA clinical trials. The committee also selected specific ways to assess each outcome. RESULTS: The core set of disease activity measures consists of a tender joint count, swollen joint count, patient's assessment of pain, patient's and physician's global assessments of disease activity, patient's assessment of physical function, and laboratory evaluation of 1 acute-phase reactant. Together, these measures sample the broad range of improvement in RA (have content validity), and all are at least moderately sensitive to change (have discriminant validity). Many of them predict other important long-term outcomes in RA, including physical disability, radiographic damage, and death. Other disease activity measures frequently used in clinical trials were not chosen for any one of several reasons, including insensitivity to change or duplication of information provided by one of the core measures (e.g., tender joint score and tender joint count). The committee also proposes specific ways of measuring each outcome. CONCLUSION: We propose a core set of outcome measures for RA clinical trials. We hope this will decrease the number of outcomes assessed and standardize outcomes assessments. Further, we hope that these measures will be found useful in long-term studies. | |
| 7540691 | HLA-DRB1 alleles associated with rheumatoid arthritis in southern France. Absence of extra | 1995 Apr | OBJECTIVE: Extraarticular rheumatoid arthritis (RA) is almost unknown in Marseille in southern France. We investigated whether this was due to rare expression of the HLA-DRB1 shared epitope. METHODS: HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization. RESULTS: In patients with RA, 76% expressed the shared epitope (46% DR1, 45% DR4). Four HLA-DRB1 alleles were positively associated with disease: DRB1*0101, DRB1*0401, DRB1*0404, DRB1*0405. Patients with double dose shared epitope had the most severe articular damage, but no extraarticular disease. CONCLUSION: In Marseille, 76% of patients with RA are shared epitope positive. Still, most do not develop extraarticular RA. This may be caused by the low frequency of HLA-DRB1*0401 in this population. | |
| 7994546 | [The use of the autocoagulation test for the detection of coagulopathies in rheumatoid art | 1993 Sep | The parameters of plasma-platelet component of hemostasis were studied by autocoagulation test in 90 patients with rheumatoid arthritis of varying activity. To specify the role of blood platelets, their counts were estimated, as was their functional activity. Plasma coagulating activity was found elevated and anticoagulating activity reduced in disease of the first and second degrees of activity, particularly so in the second degree. In patients with the third activity degree these parameters are within the normal range. The platelets augment hypercoagulation signs and reduce plasma anticoagulation potential in disease of the third degree of activity most of all. This leads to augmentation of thrombophilia signs, thus creating favorable conditions for intravascular coagulation and formation of microthrombi, which may eventually result in aggravation of rheumatoid synovitis and development of visceritis. | |
| 1536698 | Penicillamine in rheumatoid arthritis. A problem of toxicity. | 1992 Jan | Penicillamine has proved an effective second line agent in rheumatoid arthritis. Its use, however, is limited by its toxicity. Long term studies show that only between 30 and 40% of patients started on penicillamine are still taking the drug at 2 years. Toxicity is the chief reason for stopping treatment, the commonest adverse effects requiring cessation of therapy being proteinuria (10 to 13%), skin rashes (5 to 9%), gastrointestinal events (5%) and thrombocytopenia or leucopenia (2 to 5%). A number of autoimmune syndromes may rarely be induced by penicillamine. HLA-B8, Dr3 positive individuals and poor sulfoxidisers are at increased risk of developing toxicity. Meticulous supervision of penicillamine therapy is required to minimise toxicity. | |
| 8173844 | Differences in HLA-DR association with rheumatoid arthritis among migrant Indian communiti | 1994 May | Previous surveys among Indians with RA have shown a significant association with HLA DR4 in North India and with HLA DR1 in the UK. We studied a migrant Indian population in South Africa to determine their genetic associations with RA. A group of 121 unrelated RA patients from three communities (Hindi, Muslims and Tamils) were studied. The Muslims showed a significant association with DR4 but the Hindi and Tamils showed a significant association with DR10. This survey shows that the Indian community is a heterogenous group regarding their HLA associations with RA and different associations are noted in the various communities. | |
| 8310088 | Geriatric issues in the diagnosis and management of patients with rheumatic disorders. | 1993 Dec | The musculoskeletal diseases account for the most frequent complaints among older persons. Rarely is it possible to provide the patient with complete symptomatic relief. Instead, the patient needs to be taught good health habits, good concepts of preventive care, the value of rehabilitation, the gains to be achieved through non-pharmacologic therapy, and a recognition that symptoms reflect emotional problems as well as diseased musculoskeletal tissue. Most important, the patient needs to be taught that he or she can live a full exciting life despite the limitations imposed by the musculoskeletal disease. Encouragement of this attitude and institution of any and all measures that will enhance the patient's ability to retain independence are the major components of ongoing care for this growing segment of our population. | |
| 7810081 | [Rheumatoid arthritis--a diffuse connective tissue disease]. | 1994 Oct | The authors describe in a group of 100 patients, mostly with a severe form of rheumatoid arthritis, subjects with so-called "severe" extraarticular affections which can threaten the patients' lives or cause substantial deterioration of its quality, and those subjects where rheumatoid arthritis was the cause of death. These affections were associated--directly or indirectly--with the basic disease. From the absolute number of revealed affections the authors do not want to draw any conclusions as they are aware of various factors which could influence them. They assume, however, that the assembled data provide evidence that the American Rheumatological Association was right to include rheumatoid arthritis among diffuse connective tissue diseases and that it must be considered not only a disease of the locomotor apparatus but a potential disease of the organism as a whole. | |
| 7641425 | Micromotion of the acetabular component and periacetabular bone morphology. | 1995 Jan | The quality of the periacetabular bone might be an explanation for the increase in the rate of socket loosening seen radiographically in patients with rheumatoid arthritis as compared with patients with osteoarthrosis. Early implant micromotion, as measured by roentgen stereophotogrammetric analysis, is of predictive value with regard to long time retention. For uncemented porous sockets, the initial fixation might be decisive for the degree of bone ingrowth. Roentgen stereophotogrammetry was used to study cemented Charnley acetabular components in 32 hips with rheumatoid arthritis and 30 hips with osteoarthrosis, and uncemented Harris-Galante acetabular components in 19 hips with osteoarthrosis. Micromotions as long as 24 months after surgery were related to the periacetabular cancellous bone quality, as assessed by histomorphometric methods from samples taken during surgery. Acetabular components migrated more in hips with rheumatoid arthritis than in those with osteoarthrosis (p < 0.04). Hips with rheumatoid arthritis had approximately 4 times more nonmineralized bone than hips with osteoarthrosis (p < 0.0002). However, within each diagnostic group, no correlation was found between migration and the degree of mineralization (r < or = 0.24, p > or = 0.07). Migration of uncemented acetabular components did not correlate with the histomorphometric variables (r < or = 0.20, p > or = 0.42). Histomorphologic characteristics of the periacetabular trabecular bone do not seem to be of importance for acetabular component micromotion. | |
| 8882028 | The frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthrit | 1996 Feb | OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well as their demographic, clinical and biological characteristics. METHODS: Ninety-one patients with RA receiving 9.5 mg/wk of methotrexate (MTX) were compared for an average observation time of 18 months to 130 matched patients with RA treated with various drugs excluding MTX. RESULTS: Whether receiving MTX or not, 5.4% of patients with RA developed a clinical cutaneous vasculitis. There were significant differences between both groups for 2 variables only: a higher percentage of polyneuropathies and a higher level of immune complex-plasma levels in non-MTX patients. The immunohistological analysis did not differentiate both groups. CONCLUSION: The percentage of cutaneous vasculitis that developed under MTX therapy was not different from that occurring as a natural complication of longstanding severe RA. |