Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8508559 | The onset of rheumatoid arthritis in relation to pregnancy and childbirth. | 1993 Mar | It has been suggested that the onset of RA symptoms is reduced during pregnancy and increased in the postpartum period. In the present study symptom onset in relation to the pregnancy prior to disease onset was compared between 135 young RA patients with definite RA and 378 controls with soft tissue rheumatism or osteoarthritis. Two RA patients developed symptoms during pregnancy versus 9 controls (odds ratio OR = 0.64). In the 3 months postpartum 5 RA patients and 5 controls developed symptoms (OR = 3.37). These results show the same trend as those of previous studies, i.e. a decrease in the onset of RA during pregnancy and an increased onset of RA after delivery. These findings might be explained by a delayed clinical onset of RA that started during pregnancy, analogous with the ameliorating effect of pregnancy on the course of existing RA and the flare-up of disease activity in the postpartum period. | |
| 8154276 | Autologous blood transfusion with recombinant erythropoietin treatment. 22 arthroplasties | 1994 Feb | 12 anemic and 10 non-anemic patients with rheumatoid arthritis were treated with recombinant human erythropoietin (rHuEPO) before arthroplasty. The patients received 400-800 units/kg of rHuEPO subcutaneously once a week. Autologous blood was collected after the hemoglobin concentration was increased by 5 percent or more. All but one of the patients responded to the treatment. They were given 1-3 units of autologous blood, and underwent the operation without homologous blood transfusion. The mean duration of the treatment was 1 month. In 1 patient with severe anemia, additional transfusion with 2 units of blood was necessary during the operation. In all patients, there was a tendency for the hemoglobin response ratio to rHuEPO to correlate negatively with the initial CRP levels. The treatment did not affect the patients' clinical rheumatologic condition and there were no adverse effects. These results demonstrated that the treatment with subcutaneous rHuEPO is both effective and non-toxic and can therefore eliminate the need for homologous blood transfusion in anemic patients undergoing arthroplasty for rheumatoid arthritis. | |
| 8793255 | The study of circulating CD5 positive B lymphocytes in Chinese patients with rheumatoid ar | 1996 May | Circulating CD5+ B lymphocytes were studied in 39 Chinese patients with rheumatoid arthritis (RA). Blood cells were stained with anti-CD5 and anti-CD19 monoclonal antibodies and were analyzed by flow cytometry. The results showed that there was no elevation of CD5+ B cells in RA patients when compared with 41 healthy control subjects. The circulating levels of CD5+ B cell correlated neither with serum titers of rheumatoid factor (RF) nor with disease activities in these patients. The CD5+ B cell levels remained relatively constant after a serial follow-up for 12 months. The similar pattern of epitope density of CD5 antigens also existed in the same patients. Although most studies in Caucasians revealed increased levels of CD5+ B cells in RA patients, measurements of this marker were not useful for the evaluation of disease activities in Chinese patients. Levels of CD5+ B cells may reflect more individual genetic background and may play a minor role in the flare-up of activities in Chinese patients with RA. | |
| 8610221 | Production of TNF by monocytes of patients with early rheumatoid arthritis is increased. | 1995 | We studied the production of tumour necrosis factor alpha (TNF) by monocytes of patients with early rheumatoid arthritis (RA) before starting disease modifying anti-rheumatic drug treatment and a median 6 months (range 5-11 months) later, and correlated the pre-treatment results with 3-year prognosis. Monocytes of patients (n = 14) and controls (n = 14), isolated by the density gradient centrifugations, were cultured for 24 h with Escherichia coli lipopolysaccharide (LPS) 0-10 micrograms/ml. Before treatment, levels of TNF were higher in LPS-stimulated RA monocyte cultures than in the control cultures; differences were statistically significant in LPS 10 and 0.01 micrograms/ml. At 6 months, respective differences were not significant. Levels of TNF before treatment did not correlate to clinical or laboratory parameters of inflammation, or development of erosions. The results indicate that monocytes of patients with early RA are primed, and that the state of priming decreases during treatment. | |
| 7654798 | Physical fitness and work capacity in women with rheumatoid arthritis. | 1995 Sep | OBJECTIVE: To investigate physical fitness and work capacity in women with rheumatoid arthritis (RA). METHODS: The 42 subjects were a subset of a prospective trial of conditioning exercise in rheumatic disease. Assignment to an exercise or nonexercise group was determined by proximity to the intervention, a 3-month supervised group exercise program. Physical fitness and work capacity were assessed at baseline, 3 months, and 12 months. RESULTS: At baseline, subjects were deconditioned and limited in hand function, lifting ability, and lower extremity mobility. Only the exercise group improved their aerobic capacity and exercise tolerance. There were no significant changes in measured work capacity in either group. Moderate to strong correlations were found between aerobic capacity, mobility, hand function, and work capacity. Grip strength was a strong and consistent correlate of work capacity. CONCLUSION: Our findings suggest that physical capacity, particularly hand function, may be important in the complex phenomenon of work disability in RA. | |
| 8761186 | Correlates of functional disability in early rheumatoid arthritis: a cross-sectional study | 1996 Aug | In this cross-sectional study of 706 European patients with rheumatoid arthritis (RA) of < or = 4 yr duration, we examined possible correlates of functional disability assessed by the Health Assessment Questionnaire. First, we examined a subsample of 237 Norwegian patients. The Ritchie index, sex, age, erythrocyte sedimentation rate (ESR) and disease duration correlated significantly with disability, whereas serum rheumatoid factor, hand X-ray changes and educational level did not. Subsequently, we cross-validated these findings in a similar sample of 469 French, Dutch and Northern Irish patients. The results supported the Ritchie index, sex, ESR and disease duration as significant correlates of disability, whereas rheumatoid factor, age and education were not significantly correlated with disability. The correlation between X-ray changes and disability could not be cross-validated. The main findings of this study are that female sex correlates significantly with disability even early in the course of RA, whereas the rheumatoid factor does not. | |
| 8163973 | Improved radiographic survival of the Charnley prosthesis in rheumatoid arthritis and oste | 1994 Feb | Two hundred one consecutive, primary, noninfected Charnley (Thackray, Leeds) hip arthroplasties, implanted from 1968 to 1985 due to adult-onset rheumatoid arthritis, were matched in pairs with respect to year of operation, age, and sex with 201 Charnley prostheses implanted due to osteoarthritis. The 10-year survival estimate for nonrevisions was 95% in the rheumatoid group and 89% in the osteoarthritic group. Using definite radiographic loosening as a determinant, the 7-year survival rate for stems increased from 80% to 96% for both groups after the introduction of new cementing techniques, and the relative risk for stem loosening was decreased to one fifth. In the rheumatoid arthritis group, the 7-year radiographic socket survival increased from 87% to 96%, an increase ascribed to the overall effect of the introduction of flanged sockets, bone-grafts in acetabular protrusion, the rejection of the pilot hole technique, and improvements in the cement handling technique. In the osteoarthritis group the radiographic socket survival rate at 7 years was 97% and at 10 years was 95%. | |
| 7667782 | [The effect of hemosorption and plasmapheresis on fibrinogen-125I kinetics in patients wit | 1995 | 125I-labelled fibrinogen kinetics has been studied in 73 patients with rheumatoid arthritis (RA). Of them, 53 subjects underwent hemosorptions or hemosorptions combined with plasmapheresis. Fibrinogen metabolism in RA patients appeared enhanced versus healthy controls. It was observed that hemosorption treatment or its combination with plasmapheresis produce positive changes in clinical and laboratory RA parameters, improve fibrinogen metabolism. The study of fibrinogen kinetics is useful in assessing efficacy of on-going treatment. | |
| 7956565 | [Evaluation of anti-rheumatoid arthritis 36 kD and anti-33 kD antibodies in the diagnosis | 1994 Apr | By using soluble nuclear extracts from Ehrlich mice ascite cells, immunoblot analysis showed reactivity of rheumatoid arthritis (RA) serum with a 36 kD band. It was found that 28 of 88 patients with RA had anti-RA 36 kD antibody (31.8%), but there was no reactivity in the serum samples from 100 patients with other connective tissue diseases and 40 normal controls. However, the nuclear antigen mentioned above could react with either anti-RA 33 kD antibody or anti-RNP antibody in the 33 kD band. Thus, anti-RA 33 kD antibody was not a specific antibody for RA. Anti-RA 36 kD antibody appeared to be a marker antibody in RA. If anti-RA 36 kD and anti-33 kD antibodies appeared in a serum sample simultaneously, it might be more valuable for the diagnosis of RA. | |
| 7685626 | Clonal chromosome aberrations in cell cultures of synovial tissue from patients with rheum | 1993 Apr | Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up to 20% of the analyzed cells, with an increase of the proportion of cells with +7 with the duration of the in vitro culture. Apart from this recurrent change, a variety of partly clonal, partly nonclonal numerical and structural chromosome aberrations were observed in all cases. These findings support the view that clonal chromosome aberrations may play a role in the pathogenesis of invasive growth of the synovial tissue in rheumatoid arthritis although the localized synovial hyperproliferation is not a true neoplastic process. | |
| 8685145 | [Combination regimens in rheumatoid arthritis]. | 1996 Jun 1 | The objective of combination regimens in the treatment of rheumatoid arthritis is to improve effectiveness (additive or synergistic effect) and reduce the rate of side effects. Many combinations have been tried. In general, compared with single-drug regimens, combination therapy does not increase toxicity but clinical improvement has not been proven. In addition, there is no evidence concerning the long-term effects of combination regimens. Despite these drawbacks, combining drugs known to be effective in rheumatoid arthritis alone may be an interesting alternative for patients who have responded incompletely to single drugs, particularly methotrexate. However, for both single-drug and combination regimens we are still lacking proof of a real beneficial effect in terms of reducing functional impairment, improving quality of life, lengthening life expectancy, or reducing overmortality resulting from rheumatoid arthritis. Long-term outcome may provide some answers. Finally, there are still several combinations to be studied including methotrexate with "targeted" drugs such as anti-CD4 and anti-TNF alpha antibodies or the soluble TNF alpha receptor. | |
| 8316907 | [Two cases of RA-like and SLE-like features similar to remitting seronegative symmetrical | 1993 Apr | In 1985, McCarty et al reported 10 patients with a symmetrical synovitis affecting predominately the wrists and flexor digitorum tendon sheaths associated with marked pitting edema of the dorsum of both hands and both feet. It was insisted on the clinical entity as remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome). These patients were mostly elderly men whose sera revealed negative rheumatoid factor and had a benign clinical course. Patients with RS3PE syndrome remitted completely within 3-36 months and the remission was maintained even after all medications were discontinued. We experienced 2 interesting cases which were similar to RS3PE syndrome. One case with SLE-like conditions evolved into RA-like conditions. On the contrary, the other which had been effectively treated as RA developed into SLE-like conditions. Both cases were seronegative and had the characteristic pitting edema of both hands and feet demonstrating the symmetrical synovitis without bony erosions. They went into complete remission by corticosteroid therapy, although it did not continue for a long time. We should consider that such cases are similar to RS3PE syndrome and must be distinct from it. | |
| 8276055 | Acetylator polymorphism in rheumatoid arthritis. | 1993 | Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women. | |
| 8933161 | The role of macrophages in chronic arthritis. | 1996 Oct | Rheumatoid arthritis is characterized by a mononuclear infiltrate in the synovial tissue of the affected joints, considerable thickening of the synovial lining layer and concomitant destruction of cartilage and bone. Macrophages probably play a central role and the contribution of the synovial lining macrophages is addressed in studies in experimental murine arthritis models. Emphasis is given to the involvement in arthritis expression and cartilage destruction. The role of TNF-alpha and IL-1, and the modulatory cytokines IL-4/ IL-10 is briefly discussed. | |
| 8846544 | A perspective on anti-cytokine and anti-T cell-directed therapies in rheumatoid arthritis. | 1995 Sep | Clinical trials have provided a unique opportunity to test the consequences of specific interactions between biologically therapeutic modalities--mainly monoclonal antibodies (mabs) and recombinant proteins--and molecular targets in RA. Biological agents directed against T cell surface markers effectively deplete CD4+ lymphocytes, in some instances for prolonged periods. To date such therapies have shown promising results in 'open label' trials, but in those instances in which randomized placebo-controlled trials have been undertaken, there has been a failure to demonstrate significant benefit over placebo. In contrast, randomized clinical trials with a single cycle of neutralizing anti-TNF alpha mabs have shown substantial benefit in the majority of patients, with marked reduction in CRP lasting several weeks. IL-1 blockade with IL-1 ra and soluble IL-1 R showed possible efficacy in early trials but their performance is much less striking when compared with anti-TNF alpha therapy. Overall the results of trials with anti-T cell and cytokine blockade may reflect on the biological properties of the agents chosen for trial, rather than giving a conclusive answer on the relative merits of targeting these molecules in RA. Nevertheless, promising new directions for therapy and concepts of disease pathogenesis are emerging from the new era of hypothesis testing by specific biological therapies. | |
| 7552070 | Cytokine expression in chronic inflammatory disease. | 1995 Apr | In chronic inflammatory diseases, typified by rheumatoid arthritis, we speculated that upregulation and/or disregulation of cytokine production in inflamed tissue might contribute both directly and/or indirectly to the pathology in the synovial joint tissue. This chapter summarises studies performed principally by our own group over the last 9 years or so, but also by others in the field who have investigated the expression of cytokines in RA. From our studies we identified one particular cytokine, tumour necrosis factor alpha (TNF alpha) as an important, 'pivotal', molecule in the disease process. This concept has led to the initiation and completion of the first successful clinical trials in RA patients to verify this hypothesis, using a neutralising antibody to TNF alpha. | |
| 8432672 | Rheumatoid arthritis, relapsing polychondritis, and pyoderma gangrenosum evolving into non | 1993 Feb | In human beings, the function of the immune system and of inflammation is to protect the individual against invading organisms such as bacteria, viruses, parasites, and fungi as well as thermal and mechanical injuries. The inflammatory process, initiated to destroy foreign organisms or an inappropriate immune response/target tissue, may lead to injury, the destruction of host tissue, and the development of the disease process. This article describes the history of a patient with four disorders of unknown cause, all of which may have evolved from one immunologic aberration. | |
| 11625129 | [The history of rheumatoid arthritis]. | 1995 | The paper is a brief survey of the manner by which rheumatoid arthritis appears in modern clinical practice. The symmetric joint involvement, the location of synvial inflammatory changes in the joints of the hands, and the erosive bone lesions are stressed. The past and present nomenclature of chronic arthritis as well as the differential diagnostic possibilities, especially gout, are discussed. Rheumatoid arthritis may be of recent origin in Europe. The first reliable description of the disease was published in the year 1800. The medical and nonmedical literature, the visual arts, and the paleopathological examinations of skeletal findings from ancient and mediaeval times have failed to disclose certain evidence of the existance of the disease in The Old World before 1800, but bone changes found in skeletal material excavated in a district in America may indicate the existance of the disease here two or three thousand years ago. Since rheumatoid arthritis seems to have a hereditary as well as an environmental etiology the disease may have been brought from The New World to the Old World after the time of Columbus. | |
| 1588761 | [Epidemiology, prognosis and causes of death in rheumatoid arthritis]. | 1992 Mar | The prevalence of RA in Japan has been reported to be approximately 0.3% of general population and the ratio of male to female patients is 1 to 4. The course of RA is classified into 3 types, those are monocyclic, polycyclic and progressive. The polycyclic and progressive courses of RA would have been ameliorated by the recent progress of medical and surgical treatment and an increased number of patients in monocyclic course would be expected. The mortality rate among RA patients is higher than that of population control. There are causes of death directly related to rheumatoid process itself and resulted from drug treatment. The former includes secondary amyloidosis and basilar impression and the latter includes infection, renal failure and GI bleeding. | |
| 8185688 | Safe and effective isokinetic knee extension training in rheumatoid arthritis. | 1994 May | OBJECTIVE: To evaluate the safety of isokinetic knee extensor strength training, and its effectiveness with regard to knee extension, in patients with rheumatoid arthritis (RA). METHODS: Nine women with RA, all in functional stage II or III, underwent a low-intensity strengthening protocol with 48 repetitions at 50% of maximal voluntary contraction, 3 times per week for 3 weeks, using an isokinetic dynamometer. RESULTS: Five patients had knee synovitis at entry; but neither synovitis nor joint pain increased. The mean gain in strength was 21%. CONCLUSION: This training method was effective and safe in patients with RA. |