Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8097536 | Validity of single variables and indices to measure disease activity in rheumatoid arthrit | 1993 Mar | We compared the sensitivity of several variables in 2 trials between second-line agents in our clinic. In a trial comparing sulfasalazine with hydroxychloroquine significant differences were found in favor of sulfasalazine by the Ritchie score, number of swollen joints, disease activity score (DAS), physical disability and radiographic damage. This could not be determined by number of tender joints, patient's global assessment, pain, morning stiffness, or erythrocyte sedimentation rate (ESR). In a trial comparing methotrexate with azathioprine significant differences could be found in favor of methotrexate by the variables of pain, DAS, ESR, C-reactive protein, hemoglobin and thrombocytes; not by Ritchie score, number of tender joints and number of swollen joints. Combining the results of the various validation procedures leads to relative quality of the variables. | |
| 8406562 | Analyses of origin of synovial cells and repairing mechanisms of arthritis by allogeneic b | 1993 Jun | MRL/lpr mice spontaneously develop rheumatoid arthritis (RA)-like disease. Recently we have observed that bone marrow transplantation (BMT) with bone graft to recruit donor stromal cells can be used to treat autoimmune diseases (including RA-like lesions) in MRL/lpr mice. In this paper, we characterize the origin of synovial cells with the use of radiation chimeras and elucidate the repairing mechanism of RA by BMT. Type A synoviocytes have been thought to play an important role in the initiation of inflamed synovia, since a large number of Type A synoviocytes have been seen in inflamed synovia of both RA patients and MRL/lpr mice. Using [C57BL/6JJic-bg-->MRL/lpr] chimeric mice, we found Type A synoviocytes to be derived from donor bone marrow cells. They appeared in the inflamed synovia 4 weeks after BMT. However, at this time, the repairing process was not prominent. Serial biopsy studies revealed that newly developed T cells with normal functions play a more crucial role in the treatment of RA in MRL/lpr mice than do Type A synoviocytes. | |
| 7685225 | Effects of disease-modifying anti-rheumatic drugs, steroids and non-steroidal anti-inflamm | 1993 Jun | Elevated serum concentrations of acute-phase proteins (APPs) are a characteristic finding of rheumatic diseases, including RA. CRP is the most useful measure of disease activity and is frequently assessed in clinical trials to determine systemic improvement. The effects of different therapies for RA on CRP have been assessed in many studies. The DMARDs such as gold salts, D-penicillamine, sulphasalazine and azathioprine have been shown to reduce serum CRP concentrations significantly in patients with RA. CRP serum concentration is also reduced by the corticosteroids such as prednisone, but addition of pulse therapy with i.v. methylprednisolone had no additive effect compared with DMARDs alone. Many studies have shown that serum CRP concentrations are not reduced by NSAIDs; however, one recent study has demonstrated that CRP concentration was reduced by the NSAIDs flurbiprofen and sustained-release ibuprofen in a subgroup of patients. | |
| 1411580 | Cyclosporine in rheumatoid arthritis. | 1992 Aug | The efficacy and toxicity of cyclosporine in the treatment of patients with rheumatoid arthritis (RA) are reviewed. Most of the early trials were restricted to patients with intractable RA. The initial daily dose of cyclosporine was 5 to 10 mg/kg, which is now considered high. Of 283 cyclosporine-treated patients in nine studies, 8% discontinued the drug prematurely because of inefficacy and 17% because of adverse reactions. Cyclosporine improves clinical parameters but does not influence the erythrocyte sedimentation rate. The most important side effects are gastrointestinal intolerance and nephrotoxicity. The former is of minor importance with the present dosage schedule (starting daily dose, 2.5 mg/kg), and increments should follow the principle "go low, go slow." Guidelines are given to avoid or reduce nephrotoxicity. It may be beneficial to administer cyclosporine early in the course of RA. | |
| 8754539 | [The clinical x-ray variants of the osteolytic forms of rheumatoid arthritis of the tempor | 1996 | Patients with grave forms of generalized rheumatoid arthritis characterized by high activity and fulminant course are liable to develop osteolytic variants of destructive processes. Clinical and x-ray variants of osteolysis are as follows: surface (50%), partial (38%), and complete (22%). X-ray examination showed pseudodilatation of the articular fissure and blurred and destroyed articular surfaces. Osteolysis eventuates in the development of a false joint or fibrous ankylosis. | |
| 7785214 | [The use of low-temperature pelotherapy in the treatment of patients with rheumatoid arthr | 1995 Jan | Low-temperature peloids (t = +13, +14, +15 degrees C) application in rheumatoid arthritis patients produces local antiinflammatory, analgetic actions, suppresses immunocompetent system, improves locomotor functions. The above balneotherapy is indicated for patients with articular seropositive or seronegative RA irrespective of its activity in the presence of exudative-proliferative manifestations in the affected joints. In articular-visceral RA it is better to apply peloids in minimal activity of the inflammation. | |
| 7863281 | Arthritis after hepatitis B vaccination. Report of three cases. | 1995 | Side effects of hepatitis vaccination are rare. Only a few cases of arthritis after hepatitis vaccination have been published. We report on three cases of vaccination-induced arthritis with different resulting disease. Two cases show the pattern of reactive arthritis. None of them was associated with HLA-B27. In the third case onset of rheumatoid arthritis was triggered by hepatitis vaccination. These three cases show that arthritis after hepatitis B vaccination probably is more common than reported so far, especially in a genetically predisposed subject (two of our patients expressed HLA-DR4). | |
| 7575729 | Progressive joint destruction in a human immunodeficiency virus-infected patient with rheu | 1995 Sep | This article reports the case of a 63-year-old patient with rheumatoid arthritis (RA) whose symptoms of RA improved after the occurrence of a secondary human immunodeficiency virus (HIV) infection; however, the HIV infection did not affect the histologic parameters of joint destruction to the same extent as it did the clinical symptoms. Histologic and immunohistologic joint examinations of this patient revealed an ongoing production of cartilage- and bone-degrading enzymes by macrophages and fibroblasts, without the presence of T cells. These findings demonstrate that progressive joint destruction in RA can occur in the absence of T cells. Moreover, our results support the hypothesis that both T cell-dependent and T cell-independent pathways play a significant role in the pathogenesis of RA. | |
| 8370835 | MRI of the knee in rheumatoid arthritis: Gd-DTPA perfusion dynamics. | 1993 Sep | OBJECTIVE: Seventeen knees in 13 patients with rheumatoid arthritis (RA) were studied with MRI to clarify the dynamics of Gd-DTPA administered intravenously and to determine an optimal imaging time. MATERIALS AND METHODS: Dynamic gradient recalled echo imaging with bolus intravenous injection of Gd-DTPA was performed following unenhanced T1- and T2-weighted SE imaging. Late-phase SE or serial gradient recalled echo images were obtained following dynamic study. RESULTS: There was rapid enhancement of synovium with maximal enhancement ratio of 96-499% (mean 214 +/- 111%) with Tmax ranging from 120 to 660 s (mean 253 s). The synovial enhancement persisted over 80% of the peak enhancement for 6-27 min (average 12 min) with eventual enhancement of joint effusion from the periphery to the center beginning at 6 min to 8 min, 20 s after contrast medium injection. Complete enhancement of joint effusion was noted in four joints at 24-86 min. CONCLUSION: We conclude that enhancement of synovium in patients with RA is a time-dependent phenomenon, and an optimal imaging time would be within 5 min following contrast medium administration. | |
| 8778480 | [Three siblings with interstitial pneumonia]. | 1996 Mar | Patient 1: A 64-year-old woman was admitted for further examination after reticulonodular shadows were found on a chest X-ray film. Idiopathic interstitial pneumonia (IIP) was diagnosed. Patient 2: The 60-year-old sister of patient 1 was admitted for further examination after reticulonodular shadows were found on a chest X-ray film. IIP was diagnosed. About half a year later, her proximal interphalangeal joints had become swollen and the result of a rheumatoid hemagglutination test was positive. Therefore, the pneumonia was suspected to have been caused by a collagen-vascular disease (CVD), rheumatoid arthritis. Patient 3: The 64-year-old brother of patient 1 was examined. A chest X-ray film revealed reticulonodular shadows that were strongly suggestive of IIP. The remaining three siblings were examined. In a 62-year-old sister, the chest X-ray film was normal, but the level of anti-nuclear antigen was elevated. The fact that the level of this antigen was high in these four siblings and that the 60-year-old sister later suffered from rheumatoid arthritis suggested the presence of a factor predisposing to CVD in these siblings. The interstitial pneumonia in these siblings may have been related to CVD. | |
| 7974026 | [Increased levels of circulating hyaluronate in the sera of patients with rheumatoid arthr | 1994 Aug | We sought to assess whether serum levels of hyaluronate (HA) in patients with rheumatoid arthritis (RA) are elevated and correlated with grade of joint destruction and with laboratory data. Circulating HA levels were determined by protein binding assay of serum from 236 patients and 19 healthy controls. The greatest elevations of HA were seen in RA patients (350.7 +/- 689.5 ng/ml) than controls (33.7 +/- 24.2 ng/ml). Their levels showed only weak correlation values of CRP in laboratory data. Although HA levels of sera in stage III and IV in Steinbrocker's classification revealed significantly higher on average than ones in stage I and II (p < 0.01), there were many cases with low HA levels even in stage III and IV. Comparing HA levels between the cases with progressive and non-progressive type of hip or knee joint destruction within a year, the former (1143.6 +/- 1746.0 ng/ml median 480.1 ng/ml) presented significantly higher HA levels than the latter (245.3 +/- 255.8 ng/ml median 140.0 ng/ml) (p < 0.01). Further, one of 7 cases followed by 4 years with extremely high levels of HA showed progression of joint destruction from grade III to IV in Larsen Grade in bilateral knee joints during these times, though there were no significant correlations between HA levels and laboratory data. From above results, levels of circulating HA in the sera of patients with RA correspond to the joint destruction, not to a result of one. | |
| 8014930 | The relationship between clinical activity and depression in rheumatoid arthritis. | 1993 Dec | OBJECTIVE: To determine the extent to which clinical variables and changes in clinical variables explain depression and depression changes in patients with rheumatoid arthritis (RA). METHODS: 713 patients with RA attending an outpatient rheumatology clinic were studied at their 2 most recent clinic visits as part of their ordinary rheumatic disease care. Six demographic variables and 7 clinical variables were assessed including the Arthritis Impact Measurement Scale depression score, Stanford Health Assessment Questionnaire Functional Disability Index (HAQ-DI), visual analog scale (VAS) pain scales, joint count, grip strength, am stiffness, and erythrocyte sedimentation rate. Change scores representing the difference between the scores at the last and the next to last visit were calculated for all clinical variables. RESULTS: About 20% of the variance in depression change scores was explained by changes in clinical variables. The amount of variance explained appeared to be inversely related to the time between visits. Thirty-four percent of the variance in current levels of depression scores was explained by current clinical and demographic variables. The most important predictors of depression score and depression change were VAS Pain and HAQ-DI. At the last clinic visit between 11 and 16% of the depression score was explained by changes in depression scores since the previous clinic visit. CONCLUSION: Clinical changes explain 20% of depressive changes between visits, while 34% of current depression scores are explained by current clinical status. Changes in pain and HAQ-DI predict changes in depression. | |
| 8294758 | The Sauve-Kapandji procedure for reconstruction of the rheumatoid distal radioulnar joint. | 1993 Nov | Our experience with the Sauve-Kapandji procedure for reconstruction of the rheumatoid distal radioulnar joint is reported. Twenty-one wrists in 17 patients were followed for an average of 39 months postoperatively. Average range of motion at follow-up evaluation was pronation to 78 degrees and supination to 86 degrees. X-ray films demonstrated that significant ulnarward and palmarward translocation of the carpus was prevented. The Sauve-Kapandji procedure provides a stable ulnar side support in the rheumatoid wrist with distal radioulnar degeneration. | |
| 1588755 | [Malignant rheumatoid arthritis]. | 1992 Mar | Malignant rheumatoid arthritis (MRA) is a name for rheumatoid arthritis (RA) complicated with systemic vasculitis or other severe extra-articular manifestations, which can cause a fatal outcome. MRA is found in 4-5% of inpatients with RA. The male to female ratio is 1:1.45. Histologically, 3 main types are recognised in rheumatoid vasculitis; RA type (vasculitis with rheumatoid nodule-like appearance), PN type (fibrinoid vasculitis similar to PN), and EA type (endoarteritis obliterans). High titers of rheumatoid factor, immune complexes, hypocomplementemia, hypoproteinemia, decreased choline esterase activity, elevated alkaline phosphatase activity and leukocytosis are characteristic laboratory features of MRA. Recently, it appears that MRA is becoming less and the prognosis is getting better, perhaps due to the advancement in treatment. | |
| 1484718 | Daily coping with pain from rheumatoid arthritis: patterns and correlates. | 1992 Nov | Seventy-five individuals with rheumatoid arthritis reported their pain coping, mood, and joint pain for 75 consecutive days. Pain coping strategies used most often were taking direct action to reduce the pain and using relaxation strategies; those used least often were expressing emotions about the pain and redefining the pain to make it more bearable. Several background characteristics, including gender, disability, neuroticism, and pain control perceptions predicted use of various coping strategies. Controlling for these characteristics, individuals who used relaxation more frequently as part of their daily coping repertoire had less daily pain during the course of the study, and those who reported more overall coping efforts were more likely to display declining levels of daily pain across time. Pain severity moderated the relations of seeking emotional support and use of distraction with daily mood. At low levels of pain, greater use of these strategies related to more positive mood but, at high levels of pain, related to less positive mood. Finally, individuals who reported a greater number of distinct forms of coping were more apt to enjoy improving daily mood over the course of the study. Findings are discussed in terms of the advantages of prospective daily research designs. | |
| 7901887 | Variation in the serum IgA concentration and the production of IgA in vitro in rheumatoid | 1993 | Sulfasalazine is an efficient treatment for rheumatoid arthritis (RA), but its mode of action is not known. In RA, a correlation has been demonstrated between disease activity and the secretion of immunoglobulin A (IgA) by peripheral blood lymphocytes (PBL) in culture. Furthermore, the IgA-producing cells of the peripheral blood have been shown to originate from the mucous-associate lymphoid tissue (MALT). We studied the variations in the total IgA concentration in the serum of RA patients, and the secretion of IgA by PBL after 7 days culture in vitro, before and after treatment with sulfasalazine. A significant decrease in the serum IgA concentration was obtained, but there was no modification of the spontaneous increase in the in vitro IgA synthesis by circulating mononuclear cells. Our results suggested that the decrease in serum IgA concentration after treatment with sulfasalazine was not linked to a decrease in the IgA secretion by PBL. This does not favour a direct effect of sulfasalazine on the mucous-associated lymphoid tissue. | |
| 7599734 | Posterior tibial tendon dysfunction in rheumatoid arthritis. | 1995 Mar | Although hindfoot pathology in rheumatoid arthritis is a significant cause of disability for patients, the etiology of the planovalgus deformity is controversial. The present study surveys 99 patients with clinically proven rheumatoid arthritis for the presence and severity of hindfoot pathology. Specific attention was directed at the function of the posterior tibial tendon, as disruption of this structure has been implicated by some investigators as a cause of hindfoot deformity in rheumatoid arthritis. Assessment of posterior tibial function was by manual testing using two different grading scales, as well as by examination for several signs associated with posterior tibial tendon dysfunction. Between 13% and 64% of the study population could be considered to have posterior tibial tendon dysfunction, depending upon the specific diagnostic criteria used. Using the presence of all three of the most stringent criteria for diagnosis, 11% of patients were believed to have posterior tibial tendon dysfunction. These criteria were loss of the longitudinal arch, inability to perform a heel-rise, and lack of a palpable posterior tibial tendon. This study demonstrates that planovalgus deformity in rheumatoid arthritis can be due to clinically evident dysfunction of the posterior tibial muscle-tendon unit. There is a complex interplay between hindfoot joint disruption due to the inflammatory process and deformity due to tendinous dysfunction. If there is primary subtalar joint instability secondary to the inflammatory process, the posterior tibial tendon is rendered dysfunctional due to deranged hindfoot mechanics, as with primary posterior tibial tendon rupture. Since treatment of either condition (i.e., primary hindfoot instability or primary posterior tibial tendon rupture) is similar, the distinction is not important clinically.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 7791156 | Association of social support and the spouse's reaction with psychological distress in mal | 1995 Apr | OBJECTIVE: To determine if social support and the reaction of the spouse to the patient's pain are contributing factors to psychological distress in male and female patients with rheumatoid arthritis (RA). METHODS: Physical, social, and psychological aspects of health were assessed in 97 male and 132 female patients who were living with a spouse. Differences between male and female patients were analyzed by means of analysis of covariance while controlling for age and duration of RA. In multiple regression analyses the influence of social support and reaction of the spouse concerning psychological distress was determined after age, duration of RA, and physical functioning had been controlled. RESULTS: Criticism of the spouse significantly contributed to anxiety in male patients and to depression and anxiety in female patients. In addition, male and female patients differed in the social support resources that contributed to psychological distress. A relatively low number of friends was associated with depression in males. A relatively low level of potential support was associated with more anxiety in females. CONCLUSION: High levels of criticism of the spouse and low levels of social support are associated with more psychological distress in male and female patients. The number of friends is a social support resource in male patients and potential emotional support a resource in female patients. | |
| 8002422 | Rheumatoid arthritis and older women: economics tell only part of the story. | 1994 Sep | The triad of age, gender, and disabling chronic illness sets the stage for increased dependence and deprivation in later life. Women are three times more likely than men to be diagnosed with rheumatoid arthritis (RA). As a prototype of a chronic illness, RA affects all dimensions of a woman's life, usually beginning with physical function, which results in loss of work, social, and recreational activities. Because women incur 40% more chronic illness and live longer than men do, they require more health care and supportive services as they age. Women typically earn less money during their working lives than do men and are more likely to be economically impoverished in old age. Research is needed to identify the multidimensional impact of RA on older women and to explore treatment, life-style, and work options that will help younger cohorts of women prepare for their economic needs in old age. | |
| 1417108 | Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroili | 1992 Aug | The case is reported of a 50 year old man with longstanding seronegative rheumatoid arthritis who developed ulcerative colitis. The patient also had sacroiliitis and his tissue was typed as HLA-A2-B27 several years before the bowel disease began. A possible overlap between primary inflammatory bowel disease, complications to the treatment of rheumatoid arthritis with drugs, and gastrointestinal rheumatoid vasculitis is discussed. |