Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1613735 | Proteinases in rheumatoid arthritis. | 1992 Jan | The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. Focussing on the matrix metalloproteinases, we present an overview of the mechanisms regulating their activity. Methods of assessing their role in disease processes is exemplified by new data on stromelysin activity in remodelling joint tissues in both model systems and human disease. | |
| 8815985 | Polyurethane versus silicone for endoprosthetic replacement of the metacarpophalangeal joi | 1996 Jun | In a prospective study 12 patients with rheumatoid arthritis underwent arthroplasty of four metacarpophalangeal joints. Two different implant materials were randomly used in each hand, polyurethane (Pellethane) or silicone (Silastic). Eleven patients with 44 (21 silicone; 23 polyurethane) implants were re-examined 4.5 years (range 3-5) postoperatively. No difference was found between the implant materials regarding pain, stability of the joint or recurrence of the ulnar drift. The mean range of motion was 41 degrees (range 20 degrees-70 degrees) in the polyurethane joints compared with 42 degrees (range 15 degrees-90 degrees) in the silicone joints. The extension deficit was more pronounced in the silicone (mean 11.4 degrees) than in the polyurethane (mean 5.8 degrees) joints, and clinical signs of synovitis around the implants were more common with the silicone arthroplasties. Radiographic analysis, performed with conventional radiography and computed tomography (CT) showed one implant fracture in each group. There was a more pronounced bone resorption around silicone implants, but more sclerosis around polyurethane implants. Bony spurs interfering with function of the implant were common with both materials. | |
| 7986787 | Changes in plasma phospholipid fatty acids and their relationship to disease activity in r | 1994 Oct | In a controlled clinical trial we have recently shown that patients with rheumatoid arthritis (RA) improved after fasting for 7-10 d and that the improvement could be sustained through 3.5 months with a vegan diet and 9 months with a lactovegetarian diet. Other studies have indicated that the inflammatory process in RA can be reduced through manipulation of dietary fatty acids. A switch to a vegetarian diet significantly alters the intake of fatty acids. Therefore, we have analysed the changes in fatty acid profiles of the plasma phospholipid fraction and related these changes to disease activity. The concentrations of the fatty acids 20:3n-6 and 20:4n-6 were significantly reduced after 3.5 months with a vegan diet (P < 0.0001 and P < 0.01 respectively), but the concentration increased to baseline values with a lactovegetarian diet. The concentration of 20:5n-3 was significantly reduced after the vegan diet (P < 0.0001) and the lactovegetarian diet periods (P < 0.01). There was no significant difference in fatty acid concentrations between diet responders and diet non-responders after the vegan or lactovegetarian diet periods. Our results indicate that the changes in the fatty acid profiles cannot explain the clinical improvement. | |
| 8711920 | [Rheumatoid orthopedics and endoprosthetics of the shoulder joint]. | 1996 | The first part of the present article gives a comprehensive description of the pathology, diagnostics and forms of therapy of rheumatically impaired shoulder joints. Improved operative methods and methods such as bursectomy, synovectomy, reconstructive soft-tissue management and joint replacement depending on the stage of impediment have enhanced the use of surgery in the treatment of rheumatic shoulder joints. The second part gives a critical evaluation of indications, methods and results of modern shoulder joint replacement. A survey of written publications on the results of hemi- and total endoprostheses on the one hand, our own clinical experiences on the other, have shown that the use of modular hemiendoprostheses produces clinically excellent results with no problems of loosening of the glenoid part. | |
| 1309673 | Polyclonal origin of rheumatoid synovial T-lymphocytes. | 1992 Jan | Nineteen T-cell clones from seven patients with RA were obtained by cloning infiltrating lymphocytes from needle synovial biopsies. Southern blot analysis of the T-cell receptor (TCR) beta-chain genes in these clones revealed that there were no T-cell clones with an identical rearrangement of the TCR beta gene. These results do not support the idea that the infiltrating T-lymphocytes in RA are of monoclonal or oligoclonal origin. | |
| 1464859 | Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible associa | 1992 Oct | OBJECTIVE: To investigate body composition and serum tumor necrosis factor (TNF) levels in a series of 24 patients with rheumatoid arthritis (RA). METHODS: Body composition assessment by anthropometric measures and bioelectrical impedance. Cytokine determination in serum by ELISA: RESULTS: When compared to United States population norms, 16 of the subjects (67%) were cachectic. In regression models, lean body mass (LBM) was inversely associated with the number of swollen joints (p < 0.025). Elevated TNF-alpha was found in 3 of 5 flaring patients vs 0 of 18 patients with less active disease (p = 0.001). These 3 were all cachectic, while the 2 flaring patients without detectable TNF had normal LBM (p < 0.03). Among the whole group, there was a trend toward increasing disability with decreased LBM after adjusting for joint pain and disease duration (p < 0.07). CONCLUSION: Cachexia is common in RA, and may be cytokine driven. Given the prognostic impact of LBM wasting in other diseases, the effect of rheumatoid cachexia on outcome in RA deserves further study. | |
| 9010087 | Intravenous MRI contrast enhancement of inflammatory synovium: a dose study. | 1996 Dec | A dose study was performed of MRI intravenous contrast medium enhancement of rheumatoid synovium in the knee, comparing the enhancement with gadoteridol at doses of 0.1 and 0.3 mmol/kg. A measurable and significant difference was demonstrated which has particular relevance to the accuracy of dose calculations needed when performing quantitative studies. | |
| 1583042 | Semiconstrained arthroplasty for the treatment of rheumatoid arthritis of the elbow. | 1992 Apr | Fifty-four patients in whom a total of fifty-eight semiconstrained modified Coonrad elbow implants had been inserted for rheumatoid arthritis were followed for a mean of 3.8 years (range, two to eight years). At the latest follow-up, there was little or no pain in fifty-three elbows (91 per cent). The arc of motion was from an average point in flexion of 20 degrees to an average point in flexion of 129 degrees, representing an average increase of 12 degrees of extension and 11 degrees of flexion. The average arc of pronation was 78 degrees, an increase of 14 degrees, and the average arc of supination was 77 degrees, an increase of 18 degrees. An additional ten patients who had had insertion of ten modified Coonrad implants during the same period were followed for less than two years but were included in the assessment of complications. Fifteen (22 per cent) of the sixty-eight elbows had a complication: four, infection; eight, acute or delayed condylar or ulnar fracture; and one each, ulnar neuritis, avulsion of the triceps, and fracture of the implant. Radiographic evaluation was performed for fifty-four of the fifty-eight elbows; the other four were excluded from this evaluation because of infection. A satisfactory radiographic appearance of the cement--its extent and the absence of skip areas--was noted for all of the ulnar components and for fifty-one (94 per cent) of the humeral components. No patient had radiographic evidence of a loose implant. A reoperation was performed in six elbows (10 per cent of the fifty-eight; 9 per cent of the sixty-eight): four were done for infection; one, for insufficiency of the triceps; and one, for a fractured ulnar component. Of the fifty-eight elbows, forty (69 per cent) had an excellent result; thirteen (22 per cent), a good result; four (7 per cent), a fair result; and one, a poor result. | |
| 8782146 | Non-Hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose methotr | 1996 Jun | We describe 2 patients who developed non-Hodgkin's lymphoma during treatment with low dose methotrexate (MTX) for rheumatoid arthritis (RA). A review of the literature identified 16 more cases published in English. Among these 18 patients, the mean RA duration was 16 yrs and lymphoma developed after a mean of 2.8 yrs of treatment with MTX. The mean total dose of MTX was 1224 mg. Although 3 patients had spontaneous regression of lymphoma, 5 of the 18 patients died. It is not known whether there is cause-effect relationship between MTX and lymphoma among patients with RA. Special awareness of this possible complication of MTX is important. | |
| 1561865 | Metatarsal head resection in the deformed, symptomatic rheumatic foot. A comparison of two | 1992 | Metatarsal head resection for the symptomatic, deformed, rheumatic foot was performed in 83 feet of 49 patients via a modified plantar approach with functional after treatment, and in 64 feet of 41 patients via a dorsal approach, followed by placement in a plaster cast for 6 weeks. Both groups were comparable with regard to age, sex, and follow-up. From 1975 to 1985, 147 feet (90 patients) were operated in two different hospitals. Of these, 25 patients (39 feet) were lost to follow-up. The average follow-up was 83.3 mo. (range 33-136 mo.). Data were obtained by studying the medical records and by questionnaires sent to all patients. The results in both groups were quite similar. However a higher rate of wound-healing problems was found with the dorsal approach. The plantar approach resulted in an increase recurrence of metatarsalgia, requiring surgical revision. | |
| 7983644 | Synovial lymphocytes indicate "bacterial" agents may cause some cases of rheumatoid arthri | 1994 Aug | OBJECTIVE: To evaluate synovial lymphocyte response data from "rheumatoid" patients, to determine if "bacterial" antigens caused significant stimulation. METHODS: Two-tailed t tests, analysis of variance, and metaanalysis were applied to 3H-thymidine uptake triplicate/quadruplicate counts, resulting from microbiological antigen stimulation of synovial fluid lymphocytes. RESULTS: In 5 patients with rheumatoid arthritis, maximal synovial lymphocyte responses to chlamydial (in 3) and salmonella (in 2) antigens were significantly greater than to other tested antigens. CONCLUSION: The data, associated with other published data from similar studies, suggest that Chlamydia and pathogenic Enterobacteriaceae may be etiologically related to the arthritis of some patients with rheumatoid arthritis. | |
| 1545957 | Rheumatoid arthritis and disk derangement of the temporomandibular joint. A comparative ar | 1992 Mar | Consecutive patients with clinical diagnoses of disk derangement and rheumatoid arthritis with temporomandibular joint (TMJ) signs and symptoms were compared by clinical, radiographic, and arthroscopic examination. Synovial biopsies were obtained from patients with arthroscopic features of synovial inflammation. No clinical sign or symptom was found to be specific of rheumatoid involvement although joint crepitation was most frequently found in rheumatic patients (p less than 0.001). Tomographic features of subchondral bone involvement were more frequently revealed in TMJs of rheumatic patients (p less than 0.001). At arthroscopy rheumatic patients often showed pronounced arthrotic changes and inflammation. In contrast to patients with disk derangement, fibrosis of the TMJ was frequent (p less than 0.001). Histologic examination of obtained synovial specimens correlated well with arthroscopic findings, and more pronounced inflammation was present in specimens from rheumatic patients. | |
| 8441164 | Detecting treatment effects in patients with rheumatoid arthritis: the advantage of longit | 1993 Jan | Assessment of therapy in patients with rheumatoid arthritis is important but difficult. We examined 4 different methods of analyzing pretreatment data and assessed the difference that each made in detecting a positive effect of intramuscular gold on the patient's overall disability. The methods were (1) calculating the arithmetic mean of prior data points, (2) taking the last data point pretreatment, (3) fitting a straight line to pretreatment points and (4) fitting the pretreatment points with a quadratic equation. After comparison with matched controls (not taking remittive agents) the most significant difference was found by fitting a straight line to pretreatment data. This technique demonstrated about one-third more of intramuscular gold's effectiveness than the usual technique of using the last data point pretreatment. We conclude that statistical power is improved by obtaining and analyzing longitudinal pretreatment data appropriately. | |
| 1540033 | Treatment of early rheumatoid arthritis with rifampicin. | 1992 Jan | Following a report that seven of 20 patients with rheumatoid arthritis (RA) had come into clinical and laboratory remission after treatment with rifampicin, and that six of the seven responders had a disease duration of less than three years, 21 patients with classical or definite RA of recent onset were treated with 600 mg rifampicin and 300 mg isoniazid daily for six months. Fourteen of 21 patients completed six months' treatment, but there was no significant improvement in the mean values of the clinical and laboratory parameters measured. The improvement suggested by preliminary studies in patients with early RA is not seen in this larger group. In patients with a disease duration of less than 18 months, however, there was a significant decrease in the erythrocyte sedimentation rate and the serum concentrations of C reactive protein after treatment for six months, although there was no significant clinical improvement. Future studies of this drug in patients with RA should concentrate on this group. | |
| 7543837 | Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis | 1995 May | The expression of a series of adhesion molecules (the integrin family, the immunoglobulin superfamily, CD44 and the selectin family) on peripheral blood mononuclear cells (PBMC) from RA patients was investigated by flow-cytometry. L-Selectin (CD62L) in the selectin family was more significantly expressed on PBMC from RA patients as compared to those from normal controls. Further, RA patients exhibited a slight but significant increase of VLA-alpha 2 (CDw49b), p150,95 (CD11c), and VNR-beta (CD61) in the integrin family. The enhanced expression of L-selectin was positively correlated with disease activity. An increase in the proportion of L-selectin+CD4+ cells in PBMC from patients with RA and its clinical significance is reported. | |
| 8369887 | Viscosity of plasma and blood in rheumatoid arthritis. | 1993 Sep | Blood rheology was studied in 130 consecutive RA outpatients, 33 with and 97 without extra-articular disease (EAD), and compared with that in 88 blood donors. All rheological variables were significantly elevated in the RA patients compared with the controls. Painful joint count (PJC), morning stiffness (MS) and radiographic changes (RC) correlated significantly with plasma viscosity (PV), CRP, ESR and fibrinogen concentration (FC), but only in the group without EAD. Corrected blood viscosity (CBV) at a shear rate of 92/s correlated significantly only with MS. Multiple regression with PJC, MS and RC as dependent variables showed significant associations of PJC with PV, MS and CRP and RC with PV. Multiple regression with PV as the dependent variable showed significant associations with FC and IgG. RA patients with EAD had higher PV (P < 0.01), CBV at 92/s (P < 0.05) and ESR (P < 0.05) than the RA patients without EAD. Differences in profiles of viscosity variables between subgroups of EAD in RA patients were observed. | |
| 7650954 | Effects of acupuncture on immunoglobulins in patients with asthma and rheumatoid arthritis | 1995 Jun | The effects of acupuncture on immunoglobulins in patients with asthma and rheumatoid arthritis were studied. After acupuncture, in 20 patients with asthma, IgG increased (P < 0.01), IgM and IgE decreased (both P < 0.01), while IgA did not change markedly (P > 0.05); in 12 patients with rheumatoid arthritis, after acupuncture IgG, IgA and IgM decreased (P < 0.05, 0.05, and 0.01, respectively), while IgE did not change evidently. The results observed in these 32 patients indicate that acupuncture exerts modulation action on immunoglobulins of the human body, and that patients with asthma and rheumatoid arthritis responded effectively to acupuncture therapy, the latter might be related to the reinforcement of the immunological function by acupuncture. | |
| 8356393 | Toxicity of complement for chondrocytes. A possible source of cartilage degradation in inf | 1993 | Cartilage from patients with rheumatoid arthritis and from animals with antigen-induced arthritis is frequently contaminated with complement-containing immune complexes. A possible role for complement activation in cartilage degradation was modeled in vitro by exposing cultured bovine chondrocytes to homologous serum, and determining cytotoxicity by monitoring the release of intracellular 51Cr. Complement activation was found to be cytotoxic, having maximal effect at 20-30% serum by 18 h. Serum toxicity was ablated by heat (50 degrees C, 20 min) or methylamine treatment but not by EGTA, suggesting that in these experiments activation occurred by the alternate route. The implications of the results are discussed in relation to ultrastructural evidence for the involvement of complement in the pathogenesis of cartilage degradation in inflammatory arthritis. | |
| 8670597 | CD8 lymphocyte subsets in active polymyalgia rheumatica: comparison with elderly-onset and | 1996 Jul | The aim of this study was to evaluate CD8 lymphocyte subsets in active polymyalgia rheumatica (PMR), to determine whether low percentages of CD8+ cells could be used to differentiate PMR from elderly-onset (EORA) and adult rheumatoid arthritis (RA), and to investigate the effects of prednisone on CD8 lymphocyte subsets. A significant reduction of percentages and absolute numbers of CD8bright+ cells was observed in patients with active PMR. Both CD8bright+, CD57- and CD8bright+, CD57+ subsets were significantly reduced. Reduced percentages of CD8+ cells were observed in 55% of patients with active PMR/giant cell arteritis (GCA), in 23% with EORA and in 44% with adult RA. Prednisone therapy in PMR patients, after only 1 week, increased the lymphocyte count and the absolute numbers of lymphocyte subsets significantly. However, the percentages of CD8bright+ cells remained persistently low for the 2 yr study period in 80% of the patients with low pre-treatment levels. Our results demonstrate that CD8 cell percentage is a poor epidemiological discriminator for PMR diagnosis. Notwithstanding the rise in absolute numbers of CD8 cell subsets induced by prednisone, the persistently low percentages of CD8+ cells in a group of PMR patients indicate an abnormality connected with the disease. | |
| 8135776 | Processing of interleukin-1 beta in synovial cells freshly isolated from patients with rhe | 1994 Mar 15 | This study examined interleukin-1 beta (IL-1 beta) production by synovial cells from patients with rheumatoid arthritis (RA). Freshly isolated, plastic-adherent, synovial cells from ten of thirteen patients with RA secreted significant levels of IL-1 bioactivity, and the cells from five patients secreted more IL-1 beta bioactivity than IL-1 alpha bioactivity. Further, there was a relatively good correlation between IL-1 beta bioactivity and IL-1 beta converting enzyme (ICE) activity, suggesting that bioactive IL-1 beta is possibly generated through the action of ICE. Analysis of metabolically-labeled IL-1 by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), however, indicated that, although these cells contained both pre IL-1 alpha and beta intracellularly, they secreted predominantly pre IL-1 beta. |