RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
PTGS1	gene	CTD	Gene Symbol=PTGS1; Gene ID=5742; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Dexamethasone\|Diclofenac\|Dinoprostone\|Enalapril\|entinostat\|Famotidine\|Flurbiprofen\|Freund's Adjuvant\|glyphosate\|Indomethacin\|Minocycline\|Nabumetone\|Naproxen\|Oxygen\|Ozone\|Penicillamine\|Piroxicam\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulindac\|thymoquinone\|Tretinoin\|Vorinostat; Inference Score=71.93; Reference Count=263	details
VEGFA	gene	CTD	Gene Symbol=VEGFA; Gene ID=7422; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspartame\|Aspirin\|Betamethasone\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|Enalapril\|entinostat\|Freund's Adjuvant\|glyphosate\|Hydrocortisone\|Indomethacin\|Leflunomide\|Maneb\|Methotrexate\|Minocycline\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Prednisolone\|Prednisone\|Reactive Oxygen Species\|Resveratrol\|Tacrolimus\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|valdecoxib\|Vorinostat; Inference Score=69.16; Reference Count=226	details
IL23A	gene	CTD	Gene Symbol=IL23A; Gene ID=51561; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|Cyclophosphamide\|deoxynivalenol\|Diclofenac\|Dinoprostone\|Freund's Adjuvant\|Gold Sodium Thiomalate\|Hydroxychloroquine\|Levamisole\|Methotrexate\|Methylprednisolone\|Misoprostol\|Ozone\|Penicillamine\|Piroxicam\|Plant Extracts\|Prednisolone\|Tacrolimus\|tofacitinib; Inference Score=65.31; Reference Count=360	details
MPO	gene	CTD	Gene Symbol=MPO; Gene ID=4353; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Edaravone\|Enalapril\|Famotidine\|Freund's Adjuvant\|Hirudins\|Indomethacin\|Ketoprofen\|Methotrexate\|Methylprednisolone\|Naproxen\|Oxygen\|Penicillamine\|Phenylbutazone\|Piroxicam\|Plant Extracts\|Prednisolone\|Resveratrol\|Sulfasalazine\|Tacrolimus\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide; Inference Score=63.33; Reference Count=395	details
BCL2A1	gene	CTD	Gene Symbol=BCL2A1; Gene ID=597; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|chloroquine diphosphate\|Curcumin\|Diclofenac\|glyphosate\|Gold Compounds\|Gold Sodium Thiomalate\|Indomethacin\|Maneb\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Piroxicam\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|tamibarotene\|Tretinoin\|Vorinostat; Inference Score=60.28; Reference Count=196	details
STAT1	gene	CTD	Gene Symbol=STAT1; Gene ID=6772; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antigens\|Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|baricitinib\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Gold\|Gold Sodium Thiomalate\|Indomethacin\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Ozone\|Plant Extracts\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|tofacitinib\|Tretinoin\|triptolide; Inference Score=59.75; Reference Count=217	details
MMP2	gene	CTD	Gene Symbol=MMP2; Gene ID=4313; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Angiotensin-Converting Enzyme Inhibitors\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Edaravone\|entinostat\|Hydrocortisone\|Indomethacin\|Leflunomide\|Methotrexate\|Minocycline\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=58.45; Reference Count=234	details
TXNIP	gene	CTD	Gene Symbol=TXNIP; Gene ID=10628; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|chloroquine diphosphate\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|entinostat\|Gold Sodium Thiomalate\|Hydroxychloroquine\|Indomethacin\|Methotrexate\|Methylprednisolone\|Oxygen\|Piroxicam\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Tobacco Smoke Pollution\|triptolide\|Vorinostat; Inference Score=58.22; Reference Count=206	details
ACKR3	gene	CTD	Gene Symbol=ACKR3; Gene ID=57007; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Azathioprine\|chloroquine diphosphate\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Gold Sodium Thiomalate\|Methotrexate\|Methylprednisolone\|Oxygen\|Piroxicam\|Plant Extracts\|Prednisolone\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=58.07; Reference Count=183	details
HDAC1	gene	CTD	Gene Symbol=HDAC1; Gene ID=3065; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspartame\|Aspirin\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|Freund's Adjuvant\|glyphosate\|Methotrexate\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|Tretinoin\|triptolide\|Vorinostat; Inference Score=56.37; Reference Count=154	details
CAT	gene	CTD	Gene Symbol=CAT; Gene ID=847; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Air Pollutants\|Arsenic Trioxide\|Aspartame\|Aspirin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Dinoprostone\|Enalapril\|Famotidine\|Freund's Adjuvant\|glyphosate\|Gold\|Indomethacin\|Leflunomide\|mancozeb\|Maneb\|Meloxicam\|Methotrexate\|Methylprednisolone\|Misoprostol\|ochratoxin A\|Oxygen\|Ozone\|Penicillamine\|Pesticides\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Tacrolimus\|Thalidomide\|thymoquinone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=55.18; Reference Count=417	details
CXCL2	gene	CTD	Gene Symbol=CXCL2; Gene ID=2920; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Azathioprine\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Edaravone\|Freund's Adjuvant\|Gold\|Gold Sodium Thiomalate\|Indomethacin\|Methotrexate\|Methylprednisolone\|Naproxen\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Tobacco Smoke Pollution\|triptolide; Inference Score=54.47; Reference Count=218	details
CSF2	gene	CTD	Gene Symbol=CSF2; Gene ID=1437; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Freund's Adjuvant\|Gold\|Gold Compounds\|Hydrocortisone\|Indomethacin\|Naproxen\|Nitrites\|Ozone\|Penicillamine\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Sulfasalazine\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=53.97; Reference Count=274	details
CCN2	gene	CTD	Gene Symbol=CCN2; Gene ID=1490; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Angiotensin-Converting Enzyme Inhibitors\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Enalapril\|Freund's Adjuvant\|Indomethacin\|Leflunomide\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Piroxicam\|Plant Extracts\|Prednisolone\|Resveratrol\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=53.35; Reference Count=194	details
STAT4	gene	CTD	Gene Symbol=STAT4; Gene ID=6775; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antigens\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Indomethacin\|Maneb\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Piroxicam\|Prednisolone\|Resveratrol; Inference Score=52.65; Reference Count=168	details
IGFBP3	gene	CTD	Gene Symbol=IGFBP3; Gene ID=3486; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Azathioprine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|entinostat\|Indomethacin\|Leflunomide\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulfasalazine\|tamibarotene\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib; Inference Score=52.25; Reference Count=200	details
MARCKS	gene	CTD	Gene Symbol=MARCKS; Gene ID=4082; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|chloroquine diphosphate\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|entinostat\|Gold Sodium Thiomalate\|Indomethacin\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Ozone\|Piroxicam\|Prednisolone\|Tobacco Smoke Pollution; Inference Score=51.76; Reference Count=188	details
ABCB1	gene	CTD	Gene Symbol=ABCB1; Gene ID=5243; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Chlorambucil\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Cyclosporins\|deoxynivalenol\|Dexamethasone\|Hydrocortisone\|Meloxicam\|Methotrexate\|Methylprednisolone\|Naproxen\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Prednisolone\|Prednisone\|Quinacrine\|Resveratrol\|Tacrolimus\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib\|Vorinostat; Inference Score=51.68; Reference Count=216	details
FKBP5	gene	CTD	Gene Symbol=FKBP5; Gene ID=2289; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Cyclosporine\|Dexamethasone\|Edaravone\|entinostat\|glyphosate\|Hydrocortisone\|Indomethacin\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Resveratrol\|Tacrolimus\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib; Inference Score=51.61; Reference Count=155	details
IL18	gene	CTD	Gene Symbol=IL18; Gene ID=3606; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Famotidine\|Glucocorticoids\|Indomethacin\|Methotrexate\|Oxygen\|Ozone\|Prednisolone\|Reactive Oxygen Species\|Resveratrol\|Thalidomide\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=50.03; Reference Count=177	details