RABC

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Biomarkers name	Biomarker Type	Source database	Information	Details
FASLG	gene	CTD	Gene Symbol=FASLG; Gene ID=356; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Angiotensin-Converting Enzyme Inhibitors\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Enalapril\|Freund's Adjuvant\|mancozeb\|Naproxen\|ochratoxin A\|Oxygen\|Plant Extracts\|Reactive Oxygen Species\|Resveratrol\|Tacrolimus\|Thalidomide\|Tretinoin\|Vorinostat; Inference Score=49.93; Reference Count=66	details
DDIT4	gene	CTD	Gene Symbol=DDIT4; Gene ID=54541; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Cyclophosphamide\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|glyphosate\|Gold\|Leflunomide\|mancozeb\|Maneb\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Ozone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib; Inference Score=49.67; Reference Count=176	details
TNFAIP2	gene	CTD	Gene Symbol=TNFAIP2; Gene ID=7127; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Antirheumatic Agents\|Azathioprine\|chloroquine diphosphate\|Cyclosporine\|entinostat\|Gold Sodium Thiomalate\|Leflunomide\|Methotrexate\|Methylprednisolone\|Oxygen\|Plant Extracts\|Prednisolone\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=48.85; Reference Count=178	details
ABCC4	gene	CTD	Gene Symbol=ABCC4; Gene ID=10257; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Angiotensin-Converting Enzyme Inhibitors\|Antirheumatic Agents\|Arsenic Trioxide\|Aspirin\|Azathioprine\|Cyclosporine\|Dexamethasone\|Diclofenac\|Dinoprostone\|Enalapril\|entinostat\|Kynurenic Acid\|Meloxicam\|Methotrexate\|Oxygen\|Ozone\|Reactive Oxygen Species\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=48.39; Reference Count=169	details
ABCG2	gene	CTD	Gene Symbol=ABCG2; Gene ID=9429; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Azathioprine\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Cyclosporins\|Dexamethasone\|Kynurenic Acid\|Methotrexate\|Methylprednisolone\|Naproxen\|ochratoxin A\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulfasalazine\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|Vorinostat; Inference Score=47.14; Reference Count=207	details
CTSD	gene	CTD	Gene Symbol=CTSD; Gene ID=1509; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Freund's Adjuvant\|glyphosate\|Indomethacin\|Leflunomide\|Methylprednisolone\|Ozone\|Plant Extracts\|Resveratrol\|tamibarotene\|Tobacco Smoke Pollution\|Tretinoin\|valdecoxib\|Vorinostat; Inference Score=46.86; Reference Count=87	details
ADORA2A	gene	CTD	Gene Symbol=ADORA2A; Gene ID=135; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Aspirin\|Azathioprine\|chloroquine diphosphate\|Curcumin\|Diclofenac\|Gold Sodium Thiomalate\|Leflunomide\|Methotrexate\|Methylprednisolone\|ochratoxin A\|Oxygen\|Ozone\|Piroxicam\|Plant Extracts\|Prednisolone\|Resveratrol\|Tretinoin; Inference Score=46.07; Reference Count=200	details
CCN1	gene	CTD	Gene Symbol=CCN1; Gene ID=3491; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Azathioprine\|Chloroquine\|chloroquine diphosphate\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|Gold Sodium Thiomalate\|Leflunomide\|Methotrexate\|Methylprednisolone\|Oxygen\|Piroxicam\|Plant Extracts\|Prednisolone\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=45.6; Reference Count=210	details
TFPI2	gene	CTD	Gene Symbol=TFPI2; Gene ID=7980; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Cyclosporine\|Dexamethasone\|entinostat\|glyphosate\|Gold\|Indomethacin\|Methotrexate\|Oxygen\|Ozone\|Prednisolone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=44.5; Reference Count=168	details
CD40	gene	CTD	Gene Symbol=CD40; Gene ID=958; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclophosphamide\|deoxynivalenol\|Dexamethasone\|entinostat\|glyphosate\|Gold\|Gold Compounds\|Hydrocortisone\|Indomethacin\|Ozone\|Plant Extracts\|Resveratrol\|Tretinoin\|Vorinostat; Inference Score=44.39; Reference Count=63	details
TNFSF14	gene	CTD	Gene Symbol=TNFSF14; Gene ID=8740; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|deoxynivalenol\|Indomethacin\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|tamibarotene\|Tretinoin; Inference Score=43.35; Reference Count=148	details
CP	gene	CTD	Gene Symbol=CP; Gene ID=1356; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Antirheumatic Agents\|Arsenic Trioxide\|Cyclosporine\|Dexamethasone\|Dinoprostone\|Freund's Adjuvant\|Indomethacin\|Leflunomide\|Nitrites\|ochratoxin A\|Oxygen\|Penicillamine\|Pesticides\|Plant Extracts\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin\|triptolide\|valdecoxib; Inference Score=43.3; Reference Count=230	details
TNFAIP3	gene	CTD	Gene Symbol=TNFAIP3; Gene ID=7128; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Air Pollutants\|Antirheumatic Agents\|Arsenic Trioxide\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Gold\|Gold Compounds\|Leflunomide\|Maneb\|Methotrexate\|ochratoxin A\|Oxygen\|Ozone\|Pesticides\|Plant Extracts\|Resveratrol\|Tobacco Smoke Pollution; Inference Score=43.18; Reference Count=170	details
TRAF6	gene	CTD	Gene Symbol=TRAF6; Gene ID=7189; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Aspirin\|Curcumin\|Cyclosporine\|deoxynivalenol\|Dexamethasone\|Enalapril\|glyphosate\|Hydroxychloroquine\|Maneb\|ochratoxin A\|Oxygen\|Resveratrol\|Sulfasalazine; Inference Score=42.51; Reference Count=64	details
ENO1	gene	CTD	Gene Symbol=ENO1; Gene ID=2023; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Antirheumatic Agents\|Curcumin\|Cyclosporine\|Dexamethasone\|Diclofenac\|glyphosate\|Gold\|Indomethacin\|Maneb\|Methotrexate\|Minocycline\|ochratoxin A\|Oxygen\|Ozone\|Resveratrol\|Tobacco Smoke Pollution\|Tretinoin\|Vorinostat; Inference Score=42.49; Reference Count=174	details
LCN2	gene	CTD	Gene Symbol=LCN2; Gene ID=3934; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Aspirin\|Chloroquine\|Curcumin\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|Diclofenac\|Freund's Adjuvant\|ochratoxin A\|Oxygen\|Ozone\|Prednisolone\|Resveratrol\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=41.4; Reference Count=84	details
IRAK1	gene	CTD	Gene Symbol=IRAK1; Gene ID=3654; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Arsenic Trioxide\|Auranofin\|Curcumin\|Cyclosporine\|deoxynivalenol\|Enalapril\|Leflunomide\|Methotrexate\|Oxygen\|Plant Extracts\|Resveratrol\|Tacrolimus\|valdecoxib\|Vorinostat; Inference Score=40.68; Reference Count=149	details
COL2A1	gene	CTD	Gene Symbol=COL2A1; Gene ID=1280; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Antirheumatic Agents\|Curcumin\|Cyclosporine\|Dexamethasone\|Dinoprostone\|entinostat\|Freund's Adjuvant\|Indomethacin\|Kynurenic Acid\|Leflunomide\|ochratoxin A\|Oxygen\|Plant Extracts\|Resveratrol\|Tretinoin\|Vorinostat; Inference Score=40.08; Reference Count=54	details
CD83	gene	CTD	Gene Symbol=CD83; Gene ID=9308; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Adjuvants, Immunologic\|Air Pollutants\|Antirheumatic Agents\|Cyclophosphamide\|Cyclosporine\|Dexamethasone\|entinostat\|Indomethacin\|Leflunomide\|Methotrexate\|Oxygen\|Ozone\|Tacrolimus\|Tobacco Smoke Pollution\|Tretinoin; Inference Score=40.05; Reference Count=160	details
CDK6	gene	CTD	Gene Symbol=CDK6; Gene ID=1021; Disease Name=Arthritis, Rheumatoid; Disease ID=MESH:D001172; Direct Evidence=marker/mechanism; Inference Network=Acetaminophen\|Air Pollutants\|Arsenic Trioxide\|Curcumin\|Cyclosporine\|Dexamethasone\|Diclofenac\|glyphosate\|Indomethacin\|Methotrexate\|Oxygen\|Ozone\|Plant Extracts\|Resveratrol\|Sulindac\|Tretinoin\|triptolide\|Vorinostat; Inference Score=39.86; Reference Count=161	details