Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6319061 | Strategies for medical treatment based on current understanding of the pathogenesis of rhe | 1984 Jan | Although empiric principles still govern most therapies available for patients with rheumatoid arthritis (RA), strategies for the medical management of RA are beginning to be appreciated in terms of their actions on pathogenetic mechanisms relevant for this disease. Evidence suggests that anti-self-reactivity is central to the perpetuation of the articular manifestations of RA and that this autoimmune process is subserved, at least in part, by T cells. Data exist indicating that therapies effective in ameliorating RA inhibit T-cell replication and function. Experimental studies have provided results that, at present, are inconclusive in terms of the degree of clinical efficacy, but these trials have shown further that methods capable of influencing T cells are promising for the future treatment of this disease. | |
| 6603165 | Immunosuppressive potential of antimalarials. | 1983 Jul 18 | A hypothesis concerning the mechanism whereby chloroquine phosphate and hydroxychloroquine sulfate are therapeutically active in rheumatoid arthritis is presented, based on in vitro data that (1) utilize drug concentrations not higher than those clinically achievable, and (2) might explain mechanisms that may be applicable in treated rheumatoid arthritis patients. Simple assay systems were used: normal human peripheral blood mononuclear cells were cultured, stimulated with various nonspecific agents, and assayed either for induction of T cell proliferation or generation of immunoglobulin-secreting cells. Results indicate that chloroquine inhibits tritiated thymidine in a dose-dependent way by interfering with the accessory function of monocytes, and that chloroquine inhibits the generation of immunoglobulin-secreting cells by selectively interfering with the secretion of Interleukin 1 by monocytes. | |
| 4093925 | Insufficiency os pubis fractures in rheumatoid arthritis. | 1985 Dec | There is a paucity of information regarding insufficiency fractures of the os pubis in rheumatoid arthritis. While only 7 such fractures have been recorded thus far in the English literature, we have encountered 5 os pubis fractures in the past 4-year period. We report these cases to heighten awareness of their existence, describe their sometimes misleading clinical presentations, and to discuss possible etiologic factors. | |
| 1266419 | [Acute mediastinitis in rheumatoid arthritis)]. | 1976 Mar | During an exacerbation of rheumatoid arthritis in a 54 year old woman, an acute lifethreatening complication developed with pleuro-mediastino-pericarditis presenting as a superior vena cava obstruction-like syndrome. This was later associated with thrombosis of the left external jugular vein and a peripheral Horner's syndrome. She did also develop arterial hypertension with retinopathy and severe cardiac failure. Treatment with antirheumatic drugs and penicillin resulted in gradual improvement over the course of several months. The affected visceral organs were not permanently damaged. Knowledge of the clinical features of this condition is important, since a cure even with conservative treatment is possible. | |
| 3874606 | Cross-sectional study of rheumatoid arthritis treatment in a university hospital. | 1985 Jun | Drug prescribing patterns for the management of inpatients and outpatients with rheumatoid arthritis (RA) were investigated. The population of patients resembled published epidemiological descriptions of RA patients with respect to age and sex distribution. Multiple drug therapy was common in the treatment of both hospitalised and clinic patients. 90% of all patients with RA received non-steroidal anti-inflammatory drug (NSAID) therapy, indomethacin and naproxen being the two most frequently prescribed NSAIDs for both in- and outpatients. The vast majority of inpatients (85%) and outpatients (79%) received slow-acting antirheumatic drug (SAARD) treatment. 13% of hospitalised patients received H2-antagonist drugs in addition to their NSAIDs. A high proportion of inpatients (46%) received oral corticosteroids in the management of their rheumatoid arthritis, while only 15% of clinic patients were prescribed corticosteroids. | |
| 6945832 | Clinical significance of immune complexes in rheumatoid disease. | 1981 Jun | Circulating immune complexes were measured by the Clq binding assay in 49 cases of rheumatoid disease. Raised levels showed a positive correlation with activity of the arthritis, the number of involved joints and the erythrocyte sedimentation rate. No correlation was found with age, sex, duration of disease, rheumatoid nodules, presented of radiographic joint erosions or other haematological and serological parameters. In 12 patients the arthritis subsequently remitted and this remission in disease activity correlated with reduced levels of immune complexes. | |
| 3902861 | Rapid method for the measurement of methylprednisolone and its hemisuccinate in plasma and | 1985 Aug 9 | A rapid method for the measurement of methylprednisolone and its 21-hemisuccinate ester in plasma and urine following high dose pulse therapy is described. The drugs were extracted using Extrelut columns, eluted with ethyl acetate which was evaporated to dryness and the residue was reconstituted in chromatographic mobile phase. High-performance liquid chromatography was performed on a reversed-phase column using a mobile phase of acetonitrile-acetate buffer with detection at 251 nm. No interference from any drugs or endogenous compounds has been observed. The method has been used to analyse over 200 plasma and 150 urine samples from patients with rheumatoid disease or renal failure who have received high dose methylprednisolone hemisuccinate infusions. | |
| 6669867 | The effect of rheumatoid synovial fluid macrophages on DNA, glycosaminoglycan and collagen | 1983 | The effects of soluble factors secreted by peripheral blood monocytes and rheumatoid synovial fluid macrophages were tested on human synovial fibroblast cultures. Both monocytes and macrophages liberated factors which reduced DNA synthesis (3H-thymidine incorporation) by synovial fibroblasts. Monocyte and macrophage factors stimulated hyaluronic acid synthesis. The activation obtained with rheumatoid synovial macrophages was considerably greater than that with monocytes. Foetal bovine serum was found to have a clear stimulatory effect on the synthesis of collagen and other proteins by fibroblasts. The effects of monocyte and macrophage factors on protein synthesis in synovial fibroblasts were small: collagen synthesis was slightly increased relative to other extracellular proteins. | |
| 4062998 | Computed tomography of the hindfoot with rheumatoid arthritis. | 1985 Nov | We are performing direct, coronally oriented computed tomographic (CT) scans of the subtalar joint in patients with rheumatoid arthritis. To date, 16 examinations have been performed in 14 patients, 5 of whom were scheduled to undergo subtalar arthrodesis. Scans were 4-7-mm thick and spanned the length of the subtalar joint. CT scans depicted and localized subtalar abnormalities clearly and precisely. On CT scans, patients showed a characteristic constellation of abnormalities including: soft tissue swelling, cartilage space narrowing, bony erosions, and a pes planovalgus alignment abnormality (consisting of increased heel valgus angulation, and a tendency toward flattening of the sustentaculum tali, and medial and downward slippage of the talar head). The clarity of the CT images facilitated the surgeon's pre- and postoperative evaluation. In particular, it was easy to plan the correction of the valgus deformity, anticipate any special requirements for reinforcing the articular surfaces, and assess the results of surgery. We conclude that coronal CT scans clearly demonstrate abnormalities and help the surgeon evaluate the rheumatoid hindfoot. | |
| 457010 | [Extended elbow synovectomy in primary chronic polyarthritis. Long-term results]. | 1979 Jul 19 | In 50--70% of the rheumatoid patients arthritis of the elbow joint can be found. Early results after surgical treatment are very successful. The late results after 29 synovectomies, partly with resection of the head of the radius and neurolysis of the ulnar nerve, are presented. The follow-up time averages 6 years. We found a good relief of pain and a moderate, but persisting gain of movement. The importance of an early operation and a consequent physical therapy is pointed out. | |
| 338220 | Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membran | 1977 Sep | Synovial tissues from fifteen patients with psoriatic arthritis were investigated with direct immunofluorescence staining for immunoglobulins (IgG, IgA, and IgM) and from eigth patients for complement component C3. As control groups, there were synovial tissues from seven patients with seropositive rheumatoid arthritis and five patients with meniscal tears. In psoriatic arthritis, immunoglobulins were found in plasma cells in 93% of the cases, always with the presence of IgG (93%) but also with IgA (47%) and IgM (7%). C3 could not be demonstrated. In seropositive rheumatoid arthritis IgG was demonstrated in all patients (100%), often together with IgA (43%) and IgM (57%). C3 was found in all of these patients. In patients with meniscal tears neither immunoglobulins nor C3 could be found. The present findings indicate immunological activity in synovial membranes in psoriatic arthritis. The low amount of IgM and the lack of C3 suggest a difference compared to seropositive rheumatoid arthritis. | |
| 6324360 | [Febrile reaction to D-penicillamine]. | 1984 Mar 8 | Two personal observations of febrile reaction to D-penicillamine in patients with rheumatoid arthritis provide the opportunity for recalling the clinical presentation which is fairly uniform. The physiopathological mechanism is still unknown. In Wilson disease, progressive reintroduction of the drug may be successful. | |
| 962691 | [The importance, indication and operative technique of dorsal synovectomy of the knee join | 1976 Jul 23 | From a logical basis, it is reasonable to postulate that a synovectomy must be maximally as complete as possible. The indications and operative technique of radical synovectomy of the dorsal part of the knee joint are presented. The statistically significant improvement of the results of knee synovectomy by an additional dorsal approach is referred to. | |
| 6466395 | Laryngeal involvement in rheumatoid arthritis. A clinical, laryngoscopic, and computerized | 1984 Aug | Laryngeal involvement was evaluated in 45 patients with moderately severe rheumatoid arthritis (RA). RA duration and severity, prior laryngeal symptoms, and abnormalities detected by concurrent indirect laryngoscopy (IL) and computerized tomography (CT) were noted and correlated with changes of basilar interstitial fibrosis (BPF) found by chest radiograph. Thirty-two percent had abnormalities detected by IL, 54% had abnormalities by CT, and 36% had BPF on chest radiographs. Comparison of these groups revealed: only two symptoms (sore throat and difficulty during inspiration) were predictive of abnormalities detected by IL; no symptoms predicted abnormalities on percentage of RA patients even in the absence of symptoms; IL tends to detect mucosal and gross functional abnormalities while CT detects structural lesions; BPF shown on chest radiographs in RA patients does not appear to be correlated with cricoarytenoid arthritis as defined by IL and CT. | |
| 6251757 | 5' nucleotidase activity in the human synovial lining in rheumatoid arthritis. | 1980 Jun | 5'-Nucleotidase (EC 3.1.3.5), a plasma membrane-bound enzyme, has been assayed in unfixed tissue sections of human synovium, activity being measured by scanning and integrating microdensitometry. Activity was markedly increased in the lining cells of the rheumatoid synovial membranes. | |
| 960707 | [Extra-articular manifestations of chronic polyarthritis]. | 1976 Feb 6 | Although the chronic destructive joint processes dominate the clinical picture of chronic rheumatoid arthritis, it must not been forgotten that the disease is a systemic one, whereby certain organs or organ systems are affected either clinically or subclinically. The various possible pathogenetic mechanisms are discussed and the particular type of patient with rheumatoid arthritis who appears to be prone to extra-articular manifestations is described. Subsequently, the individual organic manifestations and the clinical picture are discussed, as well as the incidence and significance of these features. | |
| 6421028 | Mycoplasmas and arthritis. | 1983 Nov | At least 13 mycoplasma species cause arthritis in animals. In some cases it remains chronic, and in particular Mycoplasma hyorhinis in swine and Mycoplasma synoviae in poultry clinically and histologically resemble rheumatoid arthritis in man. Of patients with serologically verified Mycoplasma pneumoniae infections 0.9% had arthritis. Usually it is mild, but may sometimes be the dominant clinical feature. This mycoplasma has twice been cultured from the synovial fluid, as has Ureaplasma urealyticum. A few scientists have succeeded in isolating fastidious mycoplasmas from joint fluid specimens taken from human subjects with acute and chronic arthritis. Their subcultivation has often been difficult or unsuccessful. With the new methods available, renewed attempts to enlighten the possible role of mycoplasmas in human joint disease could now usefully be made. | |
| 6401365 | Osteoporosis in the rheumatoid hand--the effects of treatment with D-penicillamine and ora | 1983 Jan 22 | Osteoporosis is a common and important feature of rheumatoid disease which can be further influenced by the treatment administered. D-penicillamine, a lathyritic agent, can also theoretically hasten the osteoporotic process through its effect on collagen metabolism. In the present study the effects of the long-term second-line drugs D-penicillamine and oral gold (Auranofin) on bone density are presented. All the patients studied lost bone mineral over the 3-year period, but continuous D-penicillamine therapy for 1 year reversed this trend. Oral gold did not have the same effect. Measurements of bone density are an accurate indirect measurement of hand function, and there is a good correlation between hand function and the progress of osteoporosis. It is therefore suggested that treatment with D-penicillamine reverses the tendency to lose bone mineral improving synovitis, thus leading to improved hand function. | |
| 420491 | The surgical management of the arthritic hand. | 1979 Jan | The surgical management of the arthritic hand is very largely concerned with rheumatoid arthritis and Still's disease and less frequently with psoriatic and degenerative arthritis. In the rheumatoid hand the surgeon may be called upon to intervene at any point in the chain reaction leading to total deformity, performing synovectomies of joints or tendons to relieve pain or prevent further deformity, repairing ruptured tendons, restoring the mechanism of injured joints, and correcting deformities when they have been allowed to occur. The great variety of operations that may be necessary to achieve these ends, with varying degrees of success, are discussed with reference to a personal series of 970 cases and 2002 operations. | |
| 7259475 | Tarsal tunnel syndrome in rheumatoid arthritis. | 1981 Aug | Recent reports suggest an increased incidence for the general population of tarsal tunnel syndrome (TTS) in rheumatoid arthritis (RA), similar to that previously reported for carpal tunnel syndrome. Proof of this supposition could be important in the diagnosis and management of pain in the feet of patients with RA. Thirty-nine patients with a classical diagnosis of RA by clinical and laboratory criteria had electrodiagnostic studies performed on both posterior tibial nerves and other nerves as indicated. These tests found a 15% incidence of peripheral neuropathy and a 5% incidence of TTS in patients with RA. |