Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7467612 | [Feasibility and limitations of reconstructive interventions in rheumatoid arthritis and B | 1980 Dec 1 | Among the reconstructive interventions in rheumatoid arthritis preponderate the arthroplasties, among them again the resection arthroplasties in contrast to the alloarthroplasties. The resection arthroplasties are most frequently performed on the forefoot and on the hand joint and the cubital joint. The artificial joint substitute is possible nearly on every joint. As to the hip joint the problems are already satisfactorily solved, not yet, however, on the knee joint. In Bechterew's disease the indication to the alloarthroplasty is to be rendered depending less on pain than on function. In severe kyphoses the columnotomy is to be taken into consideration. | |
| 6384505 | Rheumatoid arthritis--the clinical significance of histo- and immunopathological abnormali | 1984 Aug | Biopsies of normal skin from 64 patients with rheumatoid arthritis (RA) were studied for histological abnormalities in dermal blood vessels. Thirty percent of patients had a moderate or dense infiltrate of mononuclear cells (predominantly T lymphocytes) around the vessel walls not seen in controls. This infiltrate correlated with disease activity and the presence of extraarticular manifestations. Vascular deposits of IgM often with C3 were seen in seropositive patients only and correlated with the amount of cellular infiltrate. No Ig and C deposits were seen in biopsies of seronegative patients and healthy controls. Apart from IgM and C3, IgG and/or IgA were found perivascularly in the areas of skin with leukocytoclastic vasculitis, indicating participation of other classes of immunoglobulins in immune complexes. The histological and/or immunopathological features that we found in uninvolved skin may serve as markers of disease activity and extraarticular manifestations. | |
| 629598 | Antigammaglobulin (rheumatoid factor) activity of human IgG subclasses. | 1978 Feb | A sensitive radioimmunoassay has been applied to the study of rheumatoid factor activity of IgM and IgG subclasses in serum and synovial fluid of patients with rheumatoid arthritis. Although rheumatoid factor activity was found in all four subclasses, its distribution was not the same as that of the total subclasses in normal sera. Results are discussed in relation to the possible clinical value of measuring IgG rheumatoid factor in sera and synovial fluids of patients with rheumatoid arthritis. | |
| 7079660 | Parenteral iron therapy in the anaemia of rheumatoid arthritis. | 1982 May | Thirty anaemic patients with active rheumatoid arthritis were each given 800 mg of iron , as iron dextran, intramuscularly over an interval of four weeks. The haemoglobin concentration rose significantly within two months in 26 of the patients but this was followed by a significant fall to the pre-treatment level nine months after treatment. The response to iron therapy was not related to the initial haemoglobin concentration, serum iron concentration, transferrin saturation nor to the amount of storage iron, whether assessed by bone marrow stainable iron or the serum ferritin concentration. There was an unexpected fall in the serum ferritin concentration within the first two months after treatment in half of the patients and this was followed by a rise towards the pre-treatment level during the following seven months, such that there was no apparent addition to the amount of storage iron over the period of the study. The possible mechanisms for these findings are discussed. A response to parenteral iron therapy in patients with active rheumatoid arthritis should not be regarded as evidence of iron deficiency and only by correction of the underlying inflammatory process will lasting improvement in the anaemia be obtained. | |
| 1274397 | [Knee joint prosthesis with the geomedic knee joint (author's transl)]. | 1976 Apr | Thirty-one cases of plastic knee joint operations were reported. Twenty-one patients were treated with the geomedic knee. The advantage of this joint is that only a small amount of bone must be sacraficed. The range of movement is better than that with a complete knee prosthesis with axis. | |
| 6354211 | [Rheumatoid factors: value of their determination in patients with rheumatoid arthritis]. | 1983 Aug 30 | IgM, IgA, IgG rheumatoid factors were investigated by a indirect immunofluorescence method in three groups of patients affected with rheumatoid arthritis of various picture: 30 patients with mild articular disease, 20 with severe joint involvement and 19 with articular and systemic symptoms. Rheumatoid factors occurred more frequently in patients with articular and extraarticular severe rheumatoid arthritis; moreover these patients showed higher titres and higher incidence of different immunoglobulin class rheumatoid factors in comparison with rheumatoid patients having mild joint disease. | |
| 7013058 | Physical training in rheumatoid arthritis: A controlled long-term study. II. Functional ca | 1981 | Twenty-three patients with rheumatoid arthritis have been given physical training for 4-8 years. They are compared with a control group of patients with the same disease. In order to evaluate disease outcome, patients were given a self-administered questionnaire to report ADL capacity and some attitudes and feelings concerning their situation. Results are in agreement with earlier reports and show a significantly higher ADL capacity in the trained group compared with the control group. There is a positive correlation between ADL capacity and reported amount of physical training and a negative correlation between ADL capacity and X-ray findings and findings at clinical examination. The feeling of weakness is more pronounced in the control group and patients in this group get more discomfort from joints after physical strain than patients in the trained group. A majority of patients in the two groups wish to participate in organized group-training. | |
| 7424203 | Chromosomal instability in collagen disease. | 1980 Mar | Chromosome instability is observed in patients with collagen disease. It is due to the presence of a chromosome-breaking agent in the serum which also induces chromosome breaks and rearrangements in blood cultures from healthy subjects. It is not possible to say at present whether this breakage factor is identical to that in patients with progressive systemic sclerosis, lupus erythematosus or rheumatoid arthritis. In all three diseases the agent is a substance with a low molecular weight between 1000 and 10,000 daltons. Since the enzyme superoxide dismutase has an anticlastogenic protective effect, the action of the agent on chromosomes is probably an indirect one, namely by generation of oxygen-dependent free radicals such as O2- x and OH. | |
| 6461092 | HLA and rheumatoid arthritis. A study of five families. | 1981 Aug | Five families with two or more members ill with rheumatoid arthritis were investigated clinically. Tissue typing for HLA A, B, C and D/DR antigens was performed. We could not define may HLA haplotype associated with disease within these families. However, the prevalence of the haplotypes containing HLA-DR4 was high, suggesting a direct relationship between DR4 and increased risk of contracting rheumatoid arthritis. | |
| 1274592 | Bile canalicular alkaline phosphatase in necropsy specimens of the liver and its relation | 1976 May | The histochemical patterns of the alkaline phosphatase reaction in liver specimens obtained at 185 consecutive autopsies were studied for any correlation with clinical data and post mortem findings. Alkaline phosphatase activity of bile canaliculi was found in 71 per cent of the subjects with malignant tumours not involving the liver, and in 77 per cent of the subjects with malignant tumours involving the liver. The histochemical pattern did not differ with the type of tumour. Most subjects with rheumatoid arthritis as well as most of those with centrolobular hepatic necrosis due to heart incompensation also showed alkaline phosphatase activity in the bile canaliculi. | |
| 1101572 | [Biochemical aspects of chronic rheumatic inflammation]. | 1975 Jul | Morphological phenomena in rheumatoid arthritis are closely correlated to the biochemical aberrations of connective tissue metabolism. Both, morphological and biochemical analysis of the altered tissue portions demonstrate evidence for uncontrolled proliferation resp. metabolism similar to human and experimental malignoma. The present state of biochemical knowledge in this field permits to describe the metabolic state of the afflicted tissue by means of enzyme activity and substrate pattern and to draw some conclusions in respect to the pathogenesis of inflammatory processes involved in chronic rheumatic diseases. | |
| 7030195 | Detection and measurement of rheumatoid factor using a new immunoenzyme technique with per | 1981 Mar | A new, solid-phase enzymatic technique is proposed for the detection and measurement of rheumatoid factors (RF). A complex (PAP) consisting of peroxidase and rabbit IgG anti-peroxidase antibodies was used as antigen. The sensitivity of the technique is such that even "physiological" levels of RF may be detected in the majority of serum samples. The intra-assay and inter-assay repeatability (6-8% and 12%) is better than that for either of the traditional agglutination techniques (latex fixation test and Waaler-Rose reaction, or LWR) and this means that the serological evolution of the illness may be followed more accurately for each patient. The detection of non-agglutinating RF was also possible. The antigen used (i. e. rabbit IgG) was fixed immunologically to the enzyme, hence it was not denatured by chemically labelling. This antigen resembles that of the Waaler-Rose reaction. A variation of this method enabled the detection of RF immunoglobulin class, when only the IgM fraction of the sera tested could be fixed to the solid phase by means of anti-mu F(ab')2 antibody before introduction of the antigen. The affinity constant could be measured without antibody purification. In 211 cases of adult rheumatoid arthritis, abnormally high levels of RF were revealed in 78% of the subjects using the PAP technique and in only 53% with the agglutination (LWR) techniques. On the other hand, the RF levels were within normal limits in the 51 cases of other inflammatory rheumatisms lacking RF according to LWR techniques, in 62 cases of non-inflammatory diseases (hip osteoarthrosis, low back pain) and also in the 42 cases of other inflammatory diseases. | |
| 7239500 | Diagnostic specificity of synovial lesions. | 1981 Apr | Sections of synovium from 393 operations on diseased joints were re-examined without knowledge of the clinical findings. Specimens were scored for each of 37 histopathologic features. Independently, patients were assigned to one of 10 diagnostic groups after review of all available clinical data. Computer analysis revealed statistically significant differences in the incidence of one or more histologic parameters between the members of all except three of the possible disease pairs. The possibility of exploiting these differences to increase diagnostic precision was examined. | |
| 176663 | Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cell | 1976 Mar | We have studied cells dispersed with proteolytic enzymes from rheumatoid arthritic synovectomy specimens to determine the cell type(s) responsible for joint destruction. Initially 10-50% of these cells adhered to culture dishes within 24 hr and were of two main types: small, round cells and larger, stellate cells. During 1-4 days of culture, 5-25% had Fc receptors and 25-50% showed brisk phagocytosis. Daily producition, per 10(6) cells of collagenase (EC 3.4.24.3) (after trypsin pretreatment) was up to 70 mug of collagen fibrils lysed per min at 37 degrees (70 units), of prostaglandin (PGE2), up to about 1200 ng, and of lysozyme, up to about 100 mug. Under identical conditions of assay, fibroblasts grown from explants of synovium produced no detectable collagenase or lysozyme, and PGE2 was only 2-4 ng. With the dispersed cell preparations, macrophage markers (Fc receptors and lysozyme) were undetectable after 4 days and PGE2 decreased rapidly after about 7 more days. However, collagenase production continued for 3-25 weeks, and in some cultures, after cell passage. At these later stages, large, slow-growing stellate cells were predominant and could phagocytose carbon particles if incubated for greater than 6-8 hr. Indomethacin (14 muM) inhibited PGE2 but stimulated collagenase production whereas dexamethasone (10 nM) inhibited both. Production of PGE2 and collagenase in large amounts in vitro by these cells suggests that they may be involved in joint destruction in vivo. The precise origin of these synovial cells and the mechanisms responsible for the sustained production of collagenase at a high rate remain unidentified. | |
| 6466058 | Bilateral joint replacement of hip and knee joints in patients with rheumatoid arthritis. | 1984 | Between 1973 and 1981, bilateral total replacement of hip and knee joints was performed in 22 patients with rheumatoid arthritis. During follow-up, 2 patients died of diseases not directly related to the operation. Besides these patients, there were 2 patients who could not be followed up. The remaining 18 patients constituted the subjects for study. We studied the postoperative results, emphasing improvement in the ability to perform everyday activities. Walking ability was improved in 16 patients. There was an increase in the number of patients able to rise from a chair, go up and down stairs, and get in and out of a car, bus or train. Of the 14 married patients (not including 2 patients who were unable to walk and 5 patients over 60 years of age) 7 were able to perform sexual intercourse as well as they had been able to when healthy. The patients who underwent bilateral total replacement of hip and knee joints often presented various problems, for example with regard to indications, the operative technique to use, as well as complications such as heart disease, pulmonary disease, and secondary amyloidosis. We have found, however, that bilateral total replacement of hip and knee joints can accomplish the operative objectives of eliminating pain and improving the quality of daily life in severely handicapped rheumatoid patients. | |
| 7341278 | Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK- | 1981 | The anti-inflammatory effects of indoprofen were evaluated by skin tests with mono-sodium-urate (M.S.U.) and streptokinase-streptodornase antigen (SK-SD) in 15 patients suffering from inflammatory and degenerative arthropathies. A clear-cut correlation between the short-term response to the M.S.U. skin test and the clinical response was observed in 12 patients. | |
| 300231 | Clinical significance of antibodies to native DNA as measured by a DNA binding technique i | 1977 Feb | The clinical significance of antinative DNA antibodies as measured by the Farr test was investigated in 10 patients with the articular features of rheumatoid arthritis. 5 of these patients also satisfied criteria for a diagnosis of systemic lupus erythematosus (SLE) and might be classified as rheumatoid/lupus overlap syndromes or as rheumatoids with systemic complications. None had evidence of renal disease and 3 of the 5 had Sjgøren's syndrome. The sixth patient had aggressive peripheral arthritis, alopecia, and Sjøgren's syndrome and developed anti-DNA antibodies after treatment with penicillamine. All of the 4 rheumatoid patients with no clinical features typical of SLE had some special disease feature. The first had subclinical liver disease and the other 3 had Sjøgren's syndrome in addition to localized vasculitic skin ulceration (2) and pulmonary fibrosis (1). | |
| 6306802 | [Plasma exchange in rheumatology. Technical problems, tolerance, indications]. | 1983 Apr 21 | Plasma exchange, used since 1979 in the treatment of severe rheumatoid arthritis, has been the subject of numerous publications in the recent years. According to data from a review of the literature and from our personal experience, this therapy cannot be advocated in the usual forms of rheumatoid arthritis. Because of the side-effects, the complicated technical equipment required and the short duration of therapeutic results, plasma exchange should, for the time being, be restricted to malignant forms of rheumatoid arthritis, polyvisceral exacerbations in lupus and scleroderma, and hyperviscosity syndromes in globulinopathies. | |
| 7332383 | Septic arthritis in rheumatoid disease causing bilateral shoulder dislocation: diagnosis a | 1981 Dec | Signs of sepsis may be obscure in patients with rheumatoid arthritis, particularly in association with long-term steroid therapy. If mortality is to be avoided, a high index of suspicion must be maintained for the diagnosis, and doubtful joints should be aspirated for culture and prompt therapy with the correct antibiotic. In this report a patients with advanced rheumatoid arthritis presented with bilateral shoulder dislocation due to septic arthritis. Ultrasonography was particularly helpful in guiding a 20 G needle to fluid collections with the debris-filled joint capsules and in facilitating successful aspiration. Ultrasound also provided a painless, noninvasive, and safe method of serial assessment of the joints after therapy. | |
| 9336626 | Arthroplasty of the rheumatoid wrist by silicone implants. Experience with forty cases. | 1983 | The authors report their first evaluation of 40 arthroplasties of the wrist with the Swanson implant. The indication for this procedure was principally severe damage to the wrist joint. The radiologic findings have been summarized. In regard to operative technic, there have been no major problems. In 20 cases also arthroplasty of the head of the ulnar was done. There were no significant early complications. The clinical results after 14 months, with a range of 6 to 45 months, was always satisfactory in regard to pain and the preservation useful flexion and extension. So far, tolerance to the implant seems to be satisfactory. The joint narrowing, regularily found in the new articulation, does not detract from the long-term results. Thus the authors retain a favorable impression of this arthroplasty which should find a place in the treatment of badly damaged rheumatoid wrists. In addition to relieving the pain, it preserves mobility that would be sacrificed with an arthrodesis. Among the associated procedures, the authors have been disappointed with arthroplasty of the head of the ulna and have given it up. |